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product summary
company name :
Addgene
product type :
cDNA
product name :
GFP-rab7 DN
catalog :
12660
citations: 23
Reference
Mulligan R, Magaj M, Redemann S, Yap C, Winckler B. Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP. bioRxiv. 2023;: pubmed publisher
Fox D, Ebright R, Hong X, Russell H, Guo H, LaSalle T, et al. Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade. NPJ Precis Oncol. 2023;7:25 pubmed publisher
Allen J, Pellois J. Hydrophobicity is a key determinant in the activity of arginine-rich cell penetrating peptides. Sci Rep. 2022;12:15981 pubmed publisher
DiMarco A, Qin X, McKinney B, Garcia N, Van Alsten S, Mendes E, et al. APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses. Cancer Immunol Res. 2022;10:70-86 pubmed publisher
Abdel Raouf K, Rezgui R, Stefanini C, Teo J, Christoforou N. Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands. Biology (Basel). 2021;10: pubmed publisher
Jeckel P, Kriebel M, Volkmer H. Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses. Front Mol Neurosci. 2021;14:659856 pubmed publisher
Mabe N, Fox D, Lupo R, Decker A, Phelps S, Thompson J, et al. Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. J Clin Invest. 2018;128:4413-4428 pubmed publisher
Saridaki T, Nippold M, Dinter E, Roos A, Diederichs L, Fensky L, et al. FYCO1 mediates clearance of α-synuclein aggregates through a Rab7-dependent mechanism. J Neurochem. 2018;146:474-492 pubmed publisher
Ferguson R, Subramanian V. The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent. PLoS ONE. 2018;13:e0193302 pubmed publisher
Yap C, Digilio L, McMahon L, Winckler B. The endosomal neuronal proteins Nsg1/NEEP21 and Nsg2/P19 are itinerant, not resident proteins of dendritic endosomes. Sci Rep. 2017;7:10481 pubmed publisher
Laviolette L, Mermoud J, Calvo I, Olson N, Boukhali M, Steinlein O, et al. Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein. Nat Commun. 2017;8:15866 pubmed publisher
Rodriguez L, Mohamed N, Desjardins A, Lippé R, Fon E, Leclerc N. Rab7A regulates tau secretion. J Neurochem. 2017;141:592-605 pubmed publisher
Christoforou N, Chakraborty S, Kirkton R, Adler A, Addis R, Leong K. Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage. Sci Rep. 2017;7:40285 pubmed publisher
Zemoura K, Trümpler C, Benke D. Lys-63-linked Ubiquitination of ?-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation. J Biol Chem. 2016;291:21682-21693 pubmed
Dinter E, Saridaki T, Nippold M, Plum S, Diederichs L, Komnig D, et al. Rab7 induces clearance of ?-synuclein aggregates. J Neurochem. 2016;138:758-74 pubmed publisher
Ji H, Atchison L, Chen Z, Chakraborty S, Jung Y, Truskey G, et al. Transdifferentiation of human endothelial progenitors into smooth muscle cells. Biomaterials. 2016;85:180-194 pubmed publisher
Chichger H, Braza J, Duong H, Boni G, Harrington E. Select Rab GTPases Regulate the Pulmonary Endothelium via Endosomal Trafficking of Vascular Endothelial-Cadherin. Am J Respir Cell Mol Biol. 2016;54:769-81 pubmed publisher
Zhao Z, Sagare A, Ma Q, Halliday M, Kong P, Kisler K, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015;18:978-87 pubmed publisher
Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong K. Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. PLoS ONE. 2013;8:e65963 pubmed publisher
Christoforou N, Chellappan M, Adler A, Kirkton R, Wu T, Addis R, et al. Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming. PLoS ONE. 2013;8:e63577 pubmed publisher
Kalia M, Khasa R, Sharma M, Nain M, Vrati S. Japanese encephalitis virus infects neuronal cells through a clathrin-independent endocytic mechanism. J Virol. 2013;87:148-62 pubmed publisher
Balut C, Gao Y, Murray S, Thibodeau P, Devor D. ESCRT-dependent targeting of plasma membrane localized KCa3.1 to the lysosomes. Am J Physiol Cell Physiol. 2010;299:C1015-27 pubmed publisher
Choudhury A, Dominguez M, Puri V, Sharma D, Narita K, Wheatley C, et al. Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells. J Clin Invest. 2002;109:1541-50 pubmed
product information
Catalog Number :
12660
Product Name :
GFP-rab7 DN
article :
doi10.1172/JCI15420
id934
pubmed_id12070301
bacterial resistance :
Kanamycin
cloning :
backbonepEGFP-C1
backbone_mutation
backbone_originClontech
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3BAMHI
cloning_site_5BAMHI
promoter
sequencing_primer_3SV40pA-R
sequencing_primer_5EGFP-C
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCMT2B, PRO2706, RAB7
geneRAB7A
id7879
genbank_ids
NM_004637
mutationT22N
nameRAB7 (Homo sapiens)
shRNA_sequence
size693
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagGFP
locationN terminal on insert
tagHA
plasmid copy :
IMAGE Clone collection at ATCC
resistance markers :
377
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA