| Reference |
|---|
M xfc ller T, Reichlmeir M, Hau A, Wittig I, Schulte D. The neuronal transcription factor MEIS2 is a calpain2 protease target. J Cell Sci. 2024;: pubmed publisher |
Deutzmann A, Sullivan D, Dhanasekaran R, Li W, Chen X, Tong L, et al. Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma. Nat Commun. 2024;15:963 pubmed publisher |
Xie C, Pastore S, Vincent J, Frankland P, Hamel P. Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability. Cells. 2024;13: pubmed publisher |
Randolph K, Hyder U, Challa A, Perez E, D Orso I. Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation. Viruses. 2024;16: pubmed publisher |
Murigneux E, Softic L, Aub xe9 C, Grandi C, Judith D, Bruce J, et al. Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly. Nat Commun. 2024;15:640 pubmed publisher |
Liao X, Li W, Zhou H, Rajendran B, Li A, Ren J, et al. The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells. Nat Commun. 2024;15:603 pubmed publisher |
Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye -, Ye Y, et al. c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer. Cell Death Dis. 2024;15:61 pubmed publisher |
Sharma P, Maklashina E, Voehler M, Balintova S, Dvorakova S, Kraus M, et al. Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners. Nat Commun. 2024;15:473 pubmed publisher |
Xu X, Zhu N, Zheng J, Peng Y, Zeng M, Deng K, et al. EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation. PLoS Pathog. 2024;20:e1011934 pubmed publisher |
Cho M, Kumar R, Lin C, Boyer J, Shahir J, Fagan Solis K, et al. MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis. Nature. 2024;: pubmed publisher |
Qin M, Geng E, Wang J, Yu M, Dong T, Li S, et al. LATS2 condensates organize signalosomes for Hippo pathway signal transduction. Nat Chem Biol. 2024;: pubmed publisher |
Meyers M, Cismoski S, Panidapu A, Chie Leon B, Nomura D. Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1. ACS Chem Biol. 2024;: pubmed publisher |
Wang X, Zhu Y, Liu T, Zhou L, Fu Y, Zhao J, et al. Duchenne muscular dystrophy treatment with lentiviral vector containing mini-dystrophin gene in vivo. MedComm (2020). 2024;5:e423 pubmed publisher |
Ren Q, Huang D, Zhang X, Wang Y, Zhou Y, Zhang M, et al. Two somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma. Commun Biol. 2024;7:22 pubmed publisher |
K xf6 ppke J, Keller L, Stuck M, Arnow N, Bannert N, Doellinger J, et al. Direct translation of incoming retroviral genomes. Nat Commun. 2024;15:299 pubmed publisher |
Li S, Liu B, Tan M, Juillard F, Szymula A, xc1 lvarez x, et al. Kaposi's sarcoma herpesvirus exploits the DNA damage response to circularize its genome. Nucleic Acids Res. 2024;: pubmed publisher |
Huang Y, Peng Q, Tian X, Chen C, Zhu X, Huang C, et al. Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Nat Commun. 2024;15:296 pubmed publisher |
Ma H, Adams L, Raju S, Sariol A, Kafai N, Janova H, et al. The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses. Nat Commun. 2024;15:246 pubmed publisher |
Ludzki A, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar Hmeadi M, et al. Transcriptional determinants of lipid mobilization in human adipocytes. Sci Adv. 2024;10:eadi2689 pubmed publisher |
Liu S, Qin Z, Mao Y, Wang N, Zhang W, Wang Y, et al. Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma. Theranostics. 2024;14:622-639 pubmed publisher |
Ni H, Wang Y, Yao K, Wang L, HUANG J, Xiao Y, et al. Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice. Nat Commun. 2024;15:1 pubmed publisher |
Dai Q, Ye C, Irkliyenko I, Wang Y, Sun H, Gao Y, et al. Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA. Nat Biotechnol. 2024;: pubmed publisher |
Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang S, et al. Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection. Nat Commun. 2024;15:109 pubmed publisher |
Rahman A, Butcko A, Songyekutu E, Granneman J, Mottillo E. Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling. Sci Rep. 2024;14:19 pubmed publisher |
Khan I, Li S, Tao L, Wang C, Ye B, Li H, et al. Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1. Nat Commun. 2024;15:162 pubmed publisher |
Yang X, Xu H, Yang X, Wang H, Zou L, Yang Q, et al. Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling. Nat Commun. 2024;15:36 pubmed publisher |
Xing T, Li L, Rao X, Zhao J, Chen Y, Ju G, et al. ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma. BMC Gastroenterol. 2024;24:11 pubmed publisher |
Sun Z, Kantor B, Chiba Falek O. Neuronal-type-specific epigenome editing to decrease SNCA expression: Implications for precision medicine in synucleinopathies. Mol Ther Nucleic Acids. 2024;35:102084 pubmed publisher |
Sharma S, Whitehead T, Kotowski M, Ng E, Clarke J, Leitner J, et al. A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells. Life Sci Alliance. 2024;7: pubmed publisher |
Wang P, Zhou R, Zhou R, Feng S, Zhao L, Li W, et al. Epidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium. Redox Biol. 2024;69:102976 pubmed publisher |
Bartosch A, Youth E, Hansen S, Wu Y, Buchanan H, Kaufman M, et al. ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease. J Neurosci. 2024;44: pubmed publisher |
Akagi Y, Takayama Y, Nihashi Y, Yamashita A, Yoshida R, Miyamoto Y, et al. Functional engineering of human iPSC-derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones. FEBS Open Bio. 2024;14:63-78 pubmed publisher |
Al Othman A, Bagrov D, Rozenberg J, Glazova O, Skryabin G, Tchevkina E, et al. Retrovirus-like gag protein Arc/Arg3.1 is involved in extracellular-vesicle-mediated mRNA transfer between glioma cells. Biochim Biophys Acta Gen Subj. 2024;1868:130522 pubmed publisher |
Lui V, Hoenig M, Cabrera Martinez B, Baxter R, Garcia Perez J, Bailey O, et al. A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation. J Exp Med. 2024;221: pubmed publisher |
Mishra S, Behera B, Singh V, Mahapatra K, Mundkinajeddu D, Bhat D, et al. Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma. Phytomedicine. 2024;123:155157 pubmed publisher |
Tzani A, Haemmig S, Cheng H, P xe9 rez Cremades D, Heuschkel M, Jamaiyar A, et al. FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2024;44:143-155 pubmed publisher |
Everest Dass A, Nersisyan S, Maar H, Novosad V, Schr xf6 der Schwarz J, Freytag V, et al. Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer. Mol Oncol. 2024;18:62-90 pubmed publisher |
Ma X, Mandausch F, Wu Y, Sahoo V, Ma W, Leoni G, et al. Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth. Cell Signal. 2024;113:110917 pubmed publisher |
Challa N, Sarkar A, Kapettu S, Phanithi P, Chakrabarti P, Parsa K, et al. TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells. Biochim Biophys Acta Mol Basis Dis. 2024;1870:166878 pubmed publisher |
Alonso Crisostomo L, Trendell J, Ferraresso M, Bailey S, Ward D, Scurlock Z, et al. Testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment. Int J Cancer. 2024;154:372-388 pubmed publisher |
Khurana S, Foltz D. Contribution of CENP-F to FOXM1-mediated discordant centromere and kinetochore transcriptional regulation. bioRxiv. 2023;: pubmed publisher |
Tong B, Sun Y. Activation of Young LINE-1 Elements by CRISPRa. Int J Mol Sci. 2023;25: pubmed publisher |
Lin K, Hibbert J, Lemens J, Torbey M, Steinert N, Flejsierowicz P, et al. The role of satellite cell-derived TRIM28 in mechanical load- and injury-induced myogenesis. bioRxiv. 2023;: pubmed publisher |
Anderson M, Levy A, Dharmasri P, Metzbower S, Blanpied T. Trans-synaptic molecular context of NMDA receptor nanodomains. bioRxiv. 2023;: pubmed publisher |
Hioki K, Ryan D, Thesmar I, Lynch A, Pobezinsky L, Pobezinskaya E. The mosquito effect: regulatory and effector T cells acquire cytoplasmic material from tumor cells through intercellular transfer. Front Immunol. 2023;14:1272918 pubmed publisher |
Wang Y, Hollingsworth L, Sangar xe9 L, Paredes Santos T, Krishnamurthy S, Penn B, et al. Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. bioRxiv. 2023;: pubmed publisher |
DiCesare S, Ortega A, Collier G, Daniel S, Thompson K, McCoy M, et al. GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology. bioRxiv. 2023;: pubmed publisher |
Coxon M, Dennis M, Dananberg A, Collins C, Wilson H, Meekma J, et al. An impaired ubiquitin-proteasome system increases APOBEC3A abundance. NAR Cancer. 2023;5:zcad058 pubmed publisher |
Annunziata C, Castoldi F, Jan S, Ang H, Ristovska M, Melini S, et al. A versatile method for the identification of senolytic compounds. Cell Stress. 2023;7:105-111 pubmed publisher |
Fan J, Li S, Zhang Y, Zheng J, Wang D, Liao Y, et al. Early Emerging SARS-CoV-2 Spike Mutants Are Diversified in Virologic Properties but Elicit Compromised Antibody Responses. Viruses. 2023;15: pubmed publisher |
Maitz K, Valadez Cosmes P, Raftopoulou S, Kindler O, Kienzl M, Bolouri H, et al. Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma. Cancers (Basel). 2023;15: pubmed publisher |
Huth T, Dreher E, Lemke S, Fritzsche S, Sugiyanto R, Castven D, et al. Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer. Sci Adv. 2023;9:eadh1442 pubmed publisher |
Mukashyaka P, Kumar P, Mellert D, Nicholas S, Noorbakhsh J, Brugiolo M, et al. High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos. Nat Commun. 2023;14:8406 pubmed publisher |
Ahmad N, Samoylenko A, Abene I, Abdelrady E, Zhyvolozhnyi A, Makieieva O, et al. Generation of novel in vitro flexible kidney organoid model to investigate the role of extracellular vesicles in induction of nephrogenesis. Cell Commun Signal. 2023;21:358 pubmed publisher |
Xu J, Roe J, Lee E, Tonelli C, Ji K, Younis O, et al. Engrailed-1 Promotes Pancreatic Cancer Metastasis. Adv Sci (Weinh). 2023;:e2308537 pubmed publisher |
Lee J, Park N, Nicosia M, Park J, Pruett S, Seo K. Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+CD25+FOXP3+ T Cells. J Immunol. 2023;212:421-32 pubmed publisher |
Susanto T, Hung V, Levine A, Kerr C, Yoo Y, Chen Y, et al. RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages. bioRxiv. 2023;: pubmed publisher |
Wang S, Matsumoto K, Mehlferber M, Zhang G, Aronova M, Yamada K. Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells. Cells Dev. 2023;177:203898 pubmed publisher |
Asante Y, Benischke K, Osman I, Ngo Q, Wurth J, Laubscher D, et al. PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution. Nat Commun. 2023;14:8361 pubmed publisher |
Chirasani V, Khan M, Malavade J, Dokholyan N, Hoffman B, Campbell S. Molecular basis and cellular functions of vinculin-actin directional catch bonding. Nat Commun. 2023;14:8300 pubmed publisher |
Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, et al. USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity. Mol Cancer. 2023;22:204 pubmed publisher |
Schmidt R, Ward C, Dajani R, Armour Garb Z, Ota M, Allain V, et al. Base-editing mutagenesis maps alleles to tune human T cell functions. Nature. 2023;: pubmed publisher |
Sert B, Gulden G, Teymur T, Ay Y, Turan R, Unaldi O, et al. Enhancing CAR-T cells: unleashing lasting impact potential with phytohemagglutinin activation in in vivo leukemia model. Cancer Gene Ther. 2023;: pubmed publisher |
Pekson R, Liang F, Axelrod J, Lee J, Qin D, Wittig A, et al. The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore. Proc Natl Acad Sci U S A. 2023;120:e2303713120 pubmed publisher |
Nandy K, Babu D, Rani S, Joshi G, Ijee S, George A, et al. Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Sci Rep. 2023;13:21953 pubmed publisher |
Zhu Q, Combs M, Liu J, Bai X, Wang W, Herring L, et al. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. Nat Commun. 2023;14:8187 pubmed publisher |
Broadbent D, McEwan C, Tsang T, Poole D, Naylor B, Price J, et al. The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. bioRxiv. 2023;: pubmed publisher |
Pode Shakked N, Slack M, Sundaram N, Schreiber R, McCracken K, Dekel B, et al. RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Nat Commun. 2023;14:8159 pubmed publisher |
Manesia J, Maganti H, Almoflehi S, Jahan S, Hasan T, Pasha R, et al. AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells. Cell Rep Methods. 2023;3:100663 pubmed publisher |
Seibert M, Koschade S, Stolp V, H xe4 upl B, Wempe F, Serve H, et al. The MYC-Regulated RNA-Binding Proteins hnRNPC and LARP1 Are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival. Cancers (Basel). 2023;15: pubmed publisher |
Voon H, Hii L, Garvie A, Udugama M, Krug B, Russo C, et al. Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies. Genome Biol. 2023;24:284 pubmed publisher |
Wang X, Gao Y, Miao R, Li L, Nanding A, Liu Y, et al. Risk model-guided identification of MTDH expression as a marker for ferroptosis induction therapy in head and neck squamous cell carcinoma. Am J Cancer Res. 2023;13:5236-5253 pubmed |
D Alessandro G, Morales Juarez D, Richards S, Nitiss K, Serrano Benítez A, Wang J, et al. RAD54L2 counters TOP2-DNA adducts to promote genome stability. Sci Adv. 2023;9:eadl2108 pubmed publisher |
Ramos A, Koch C, Liu Lupo Y, Hellinger R, Kyung T, Abbott K, et al. Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Nat Commun. 2023;14:8048 pubmed publisher |
Minegishi M, Kuchimaru T, Nishikawa K, Isagawa T, Iwano S, Iida K, et al. Secretory GFP reconstitution labeling of neighboring cells interrogates cell-cell interactions in metastatic niches. Nat Commun. 2023;14:8031 pubmed publisher |
Zhang S, Zeng L, Su B, Yang G, Wang J, Ming S, et al. The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication. MBio. 2023;14:e0265123 pubmed publisher |
Wang Y, Armendariz D, Wang L, Zhao H, Xie S, Hon G. Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes. bioRxiv. 2023;: pubmed publisher |
Beumers L, Vlachavas E, Borgoni S, Schwarzm xfc ller L, Penso Dolfin L, Michels B, et al. Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets. NPJ Breast Cancer. 2023;9:97 pubmed publisher |
Somborac T, Lutfullahoglu Bal G, Fatima K, Vihinen H, Paatero A, Jokitalo E, et al. The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved. PLoS ONE. 2023;18:e0295047 pubmed publisher |
Rodriguez Tirado C, Wang C, Li X, Deng S, Gonzalez J, Johnson N, et al. UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance. Oncogene. 2023;: pubmed publisher |
Nemergut M, Pluskal D, Horáčková J, Sustrova T, Tulis J, Bárta T, et al. Illuminating the mechanism and allosteric behavior of NanoLuc luciferase. Nat Commun. 2023;14:7864 pubmed publisher |
Chen K, Tang F, Du B, Yue Z, Jiao L, Ding X, et al. Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism. MedComm (2020). 2023;4:e429 pubmed publisher |
Hao W, Chen Z, Tang J, Yang R, Gao W, Xu H. hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. J Transl Med. 2023;21:861 pubmed publisher |
Ji Y, Zhang W, Shen K, Su R, Liu X, Ma Z, et al. The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer. Nat Commun. 2023;14:7794 pubmed publisher |
Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, et al. CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. Mol Cell. 2023;83:4370-4385.e9 pubmed publisher |
Rakhmatullina A, Mingaleeva R, Gafurbaeva D, Glazunova O, Sagdeeva A, Bulatov E, et al. Adipose-Derived Mesenchymal Stem Cell (MSC) Immortalization by Modulation of hTERT and TP53 Expression Levels. J Pers Med. 2023;13: pubmed publisher |
Galvin R, Jena S, Maeser D, Gruener R, Huang R. Revealing Pan-Histology Immunomodulatory Targets in Pediatric Central Nervous System Tumors. Cancers (Basel). 2023;15: pubmed publisher |
Xie J, Mo T, Li R, Zhang H, Liang G, Ma T, et al. The m7G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling. Cancers (Basel). 2023;15: pubmed publisher |
Boichuk S, Dunaev P, Skripova V, Galembikova A, Bikinieva F, Shagimardanova E, et al. Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations. Cancers (Basel). 2023;15: pubmed publisher |
Wright C, Gordon E, Cooper S. Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer. BMC Cancer. 2023;23:1137 pubmed publisher |
Morgan M, Mohammad Parast S, Iwanaszko M, Aoi Y, Yoo D, Dumar Z, et al. ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster. Sci Adv. 2023;9:eadj1261 pubmed publisher |
Li H, Gong H, Wong T, Zhou J, Wang Y, Lin L, et al. Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation. Nat Commun. 2023;14:7539 pubmed publisher |
Yang Z, Xiang Q, Nicholas J. Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2. PLoS Pathog. 2023;19:e1011806 pubmed publisher |
Sharma N, Kessler P, Sen G. Cell-type-specific need of Ddx3 and PACT for interferon induction by RNA viruses. J Virol. 2023;97:e0130423 pubmed publisher |
Machado M, Dos Santos M, Guimar xe3 es J, de Campos G, Oliveira Brito P, Ferreira C, et al. GXMR-CAR containing distinct GXM-specific single-chain variable fragment (scFv) mediated the cell activation against Cryptococcus spp. And had difference in the strength of tonic signaling. Bioengineered. 2023;14:2281059 pubmed publisher |
Zhang M, Lv L, Luo H, Cai H, Yu L, Jiang Y, et al. The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity. Vet Res. 2023;54:106 pubmed publisher |
Searcy M, Larsen R, Stevens B, Zhang Y, Jin H, Drummond C, et al. PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors. Nat Commun. 2023;14:7291 pubmed publisher |
Liu S, Wang C, Lin R, Ding W, Roy G, Wang H, et al. Super-enhancer driven SOX2 promotes tumor formation by chromatin re-organization in nasopharyngeal carcinoma. EBioMedicine. 2023;98:104870 pubmed publisher |
McGee A, Liu Y, Griffith A, Szegletes Z, Wen B, Kraus C, et al. Modular vector assembly enables rapid assessment of emerging CRISPR technologies. bioRxiv. 2023;: pubmed publisher |
Li C, Fu J, Shao S, Luo Z. Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7. bioRxiv. 2023;: pubmed publisher |
Swaby C, Yeung Luk B, Thapa S, Nishida K, Wally A, Ghosh B, et al. Decreased fucosylation impacts epithelial integrity and increases risk for COPD. bioRxiv. 2023;: pubmed publisher |
Yang J, Lim J, Victor P, Chen C, Khwaja H, Schnellmann R, et al. Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma. bioRxiv. 2023;: pubmed publisher |
Rehbein S, Possmayer A, Bozkurt S, Lotsch C, Gerstmeier J, Bürger M, et al. Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells. Cancers (Basel). 2023;15: pubmed publisher |
Valenzuela Valderas K, Farrashzadeh E, Chang Y, Shi Y, Raudonis R, Leung B, et al. RACK1 promotes Shigella flexneri actin-mediated invasion, motility, and cell-to-cell spreading. iScience. 2023;26:108216 pubmed publisher |
Long J, Chen X, Shen Y, Lei Y, Mu L, Wang Z, et al. A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment. Cell Rep Med. 2023;4:101286 pubmed publisher |
Chong A, Vandana J, Jeng G, Li G, Meng Z, Duan X, et al. Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Nat Chem Biol. 2023;: pubmed publisher |
Haydo A, Wehle A, Herold Mende C, K xf6 gel D, Pampaloni F, Linder B. Combining organotypic tissue culture with light-sheet microscopy (OTCxLSFM) to study glioma invasion. EMBO Rep. 2023;24:e56964 pubmed publisher |
Kim S, Kiser P, Asfaha S, DeKoter R, Dick F. EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells. EMBO J. 2023;42:e114462 pubmed publisher |
Pinioti S, Sharma H, Flerin N, Yu Q, Tzoumpa A, Trusso Cafarello S, et al. A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer. Cancer Immunol Res. 2023;11:1611-1629 pubmed publisher |
Mahieu C, MANCINI A, Vikram E, Planells Palop V, Joseph N, Tward A. ORAOV1, CCND1, and MIR548K are the driver oncogenes of the 11q13 amplicon in squamous cell carcinoma. Mol Cancer Res. 2023;: pubmed publisher |
Bagdonaite I, Marinova I, Rudjord Levann A, Pallesen E, King Smith S, Karlsson R, et al. Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection. Nat Commun. 2023;14:7000 pubmed publisher |
Tan I, Perez A, Lew R, Sun X, Baldwin A, Zhu Y, et al. Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis. Cell Rep. 2023;42:113339 pubmed publisher |
Bagdasarian I, Tonmoy T, Park B, Morgan J. In vitro formation and extended culture of highly metabolically active and contractile tissues. PLoS ONE. 2023;18:e0293609 pubmed publisher |
Wang Y, Hao Y, Shen M, Han X, Wang Y, Chen S, et al. The Expression of LDL-R in CD8+ T Cells Serves as an Early Assessment Parameter for the Production of TCR-T Cells. In Vivo. 2023;37:2480-2489 pubmed publisher |
Li X, Zeng S, Chen L, Zhang Y, Li X, Zhang B, et al. An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long-range loop formation. Cell Prolif. 2023;:e13552 pubmed publisher |
Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, et al. ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer. bioRxiv. 2023;: pubmed publisher |
Wang Z, Luo M, Liang Q, Zhao K, Hu Y, Wang W, et al. Landscape of enhancer disruption and functional screen in melanoma cells. Genome Biol. 2023;24:248 pubmed publisher |
Lee S, Shin J, Kwon M, Lee K, Kim H, Lee J, et al. Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation. Stem Cells Int. 2023;2023:8815888 pubmed publisher |
xd6 ktem M, Mastrobattista E, de Jong O. Amphipathic Cell-Penetrating Peptide-Aided Delivery of Cas9 RNP for In Vitro Gene Editing and Correction. Pharmaceutics. 2023;15: pubmed publisher |
Li J, Brachtlova T, van der Meulen Muileman I, Kleerebezem S, Liu C, Li P, et al. Human Non-Small Cell Lung Cancer-Chicken Embryo Chorioallantoic Membrane Tumor Models for Experimental Cancer Treatments. Int J Mol Sci. 2023;24: pubmed publisher |
Bekas N, Samiotaki M, Papathanasiou M, Mokos P, Pseftogas A, Xanthopoulos K, et al. Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency. Cancers (Basel). 2023;15: pubmed publisher |
Fu Z, He S, Wu Y, Zhao G. Design and deep learning of synthetic B-cell-specific promoters. Nucleic Acids Res. 2023;51:11967-11979 pubmed publisher |
Burigotto M, Vigorito V, Gliech C, Mattivi A, Ghetti S, Bisio A, et al. PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability. EMBO Rep. 2023;24:e57234 pubmed publisher |
Koukorava C, Ward K, Ahmed K, Almaghrabi S, Dauleh S, Pereira S, et al. Mesothelial Cells Exhibit Characteristics of Perivascular Cells in an In Vitro Angiogenesis Assay. Cells. 2023;12: pubmed publisher |
Valiullina A, Zmievskaya E, Ganeeva I, Zhuravleva M, Garanina E, Rizvanov A, et al. Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line. Mol Biol Res Commun. 2023;12:139-148 pubmed publisher |
Fala M, Ros S, Sawle A, Rao J, Tsyben A, Tronci L, et al. The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtype. Neurooncol Adv. 2023;5:vdad120 pubmed publisher |
Tsai L, Peng M, Chang C, Wen L, Liu L, Liang X, et al. ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells. Cell Biosci. 2023;13:193 pubmed publisher |
Bie N, Yong T, Wei Z, Liang Q, Zhang X, Li S, et al. Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy. Signal Transduct Target Ther. 2023;8:408 pubmed publisher |
Mohammadkhani N, Rahimpour A, Hoseinpoor R, Rajabibazl M. Development of Stable CHO-K1 Cell Lines Overexpressing Full-Length Human CD20 Antigen. Iran Biomed J. 2023;27:269-79 pubmed publisher |
Challa S, Nandu T, Kim H, Gong A, Renshaw C, Li W, et al. A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells. bioRxiv. 2023;: pubmed publisher |
Boeszoermenyi A, Bernaleau L, Chen X, Kartnig F, Xie M, Zhang H, et al. A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun. 2023;14:6626 pubmed publisher |
Dubaić M, Peskova L, Hampl M, Weissová K, Celiker C, Shylo N, et al. Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Life Sci Alliance. 2023;6: pubmed publisher |
Nan Y, Liu S, Luo Q, Wu X, Zhao P, Chang W, et al. m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation. Cell Rep. 2023;42:113273 pubmed publisher |
Lee D, Ahn H, Sim H, Choi E, Choi S, Jo Y, et al. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. J Exp Clin Cancer Res. 2023;42:272 pubmed publisher |
Lee J, Shores K, Breithaupt J, Lee C, Fodera D, Kwon J, et al. PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system. APL Bioeng. 2023;7:046103 pubmed publisher |
Park S, Cho J, Kim J, Park M, Park S, Kim S, et al. Hypoxia stabilizes SETDB1 to maintain genome stability. Nucleic Acids Res. 2023;51:11178-11196 pubmed publisher |
Kas S, Mundra P, Smith D, Marais R. Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation. Sci Rep. 2023;13:17648 pubmed publisher |
Damelang T, de Taeye S, Rentenaar R, Roya Kouchaki K, de Boer E, Derksen N, et al. The Influence of Human IgG Subclass and Allotype on Complement Activation. J Immunol. 2023;211:1725-1735 pubmed publisher |
Hong S, Lee S, Park J, Hong M, Yoon J, Lee H, et al. miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6. Sci Rep. 2023;13:17480 pubmed publisher |
Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, et al. MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice. Nat Commun. 2023;14:6493 pubmed publisher |
Fan H, Liu W, Zeng Y, Zhou Y, Gao M, Yang L, et al. DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway. Commun Biol. 2023;6:1041 pubmed publisher |
Kovacs M, Vallette M, Wiertsema P, Dingli F, Loew D, Nader G, et al. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Mol Cell. 2023;83:3659-3668.e10 pubmed publisher |
Zhu B, Fisher E, Li L, Zhong P, Yan Z, Feng J. PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes. Stem Cell Reports. 2023;18:2268-2282 pubmed publisher |
Reichlmeir M, Canet Pons J, Koepf G, Nurieva W, Duecker R, Doering C, et al. In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA. Cells. 2023;12: pubmed publisher |
Gonzalez H, Narasipura S, Shull T, Shetty A, Teppen T, Naqib A, et al. An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes. Cells. 2023;12: pubmed publisher |
Al Khayyat W, Pirkkanen J, Dougherty J, Laframboise T, Dickinson N, Khaper N, et al. Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression. Cells. 2023;12: pubmed publisher |
Otani Y, Yoshikawa S, Nagao K, Tanaka T, Toyooka S, Fujimura A. Connective tissue mast cells store and release noradrenaline. J Physiol Sci. 2023;73:24 pubmed publisher |
Guan X, Verma A, Wang G, Shi J, Perlman S, Du L. Glycosylated Delta-receptor-binding domain mucosal vaccine elicits broadly neutralizing antibodies with protection against SARS-CoV-2 challenge. iScience. 2023;26:108033 pubmed publisher |
xdc nl xfc B, Pons C, Ho U, Batt xe9 A, Aloy P, van Leeuwen J. Global analysis of suppressor mutations that rescue human genetic defects. Genome Med. 2023;15:78 pubmed publisher |
Liu N, Zhang J, Chen W, Ma W, Wu T. The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression. J Exp Clin Cancer Res. 2023;42:263 pubmed publisher |
Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, et al. FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes. Nat Commun. 2023;14:6344 pubmed publisher |
Sheehan C, Marayati B, Bhatia J, Meyer K. In situ visualization of m6A sites in cellular mRNAs. Nucleic Acids Res. 2023;51:e101 pubmed publisher |
Benton A, Terwilliger E, Moriarty N, Liu B, Murphy A, Maluvac H, et al. Target gene regulatory network of miR-497 in angiosarcoma. bioRxiv. 2023;: pubmed publisher |
Pham A, Mani M, Wang X, Vafabakhsh R. The Physical Biology of Nucleolus Disassembly. bioRxiv. 2023;: pubmed publisher |
Zhao L, Koseki S, Silverstein R, Amrani N, Peng C, Kramme C, et al. PAM-flexible genome editing with an engineered chimeric Cas9. Nat Commun. 2023;14:6175 pubmed publisher |
Williams C, Brown R, Zhao Y, Wang J, Chen Z, Blunt K, et al. MTGR1 is required to maintain small intestinal stem cell populations. Res Sq. 2023;: pubmed publisher |
Topchu I, Bychkov I, Gursel D, Makhov P, Boumber Y. NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma. bioRxiv. 2023;: pubmed publisher |
Cerda Smith C, Hutchinson H, Liu A, Goel V, Sept C, Kim H, et al. Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization. bioRxiv. 2023;: pubmed publisher |
Frenkel M, Hujoel M, Morris Z, Raman S. Discovering chromatin dysregulation induced by protein-coding perturbations at scale. bioRxiv. 2023;: pubmed publisher |
Murugan S, Nandi B, Mazumdar V, Joshi K, Nandini P, Namani S, et al. Outer membrane protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins. J Biol Chem. 2023;299:105309 pubmed publisher |
Guo S, Xu Z, Feng Q, Zhang H, Yu D, Li B, et al. Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma. Arch Biochem Biophys. 2023;747:109771 pubmed publisher |
Zhang W, Lu C, Nakamoto M, Tsai C, Roy A, Lee C, et al. Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions. Nat Cell Biol. 2023;25:1453-1464 pubmed publisher |
Hafer T, Felton A, Delgado Y, Srinivasan H, Emerman M. A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency. Viruses. 2023;15: pubmed publisher |
Akhtar J, Imran M, Wang G. CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells. Int J Mol Sci. 2023;24: pubmed publisher |
Yau K, Kurtesi A, Qi F, Delgado Brand M, Tursun T, Hu Q, et al. Omicron variant neutralizing antibodies following BNT162b2 BA.4/5 versus mRNA-1273 BA.1 bivalent vaccination in patients with end-stage kidney disease. Nat Commun. 2023;14:6041 pubmed publisher |
Domma A, Henderson L, Goodrum F, Moorman N, Kamil J. Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins. J Virol. 2023;97:e0056323 pubmed publisher |
Khaleafi R, Železnjak J, Cordela S, Drucker S, Rovis T, Jonjic S, et al. Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Front Immunol. 2023;14:1231782 pubmed publisher |
Han J, Xie C, Liu B, Wang Y, Pang R, Bi W, et al. Tetraspanin 1 regulates papillary thyroid tumor growth and metastasis through c-Myc-mediated glycolysis. Cancer Sci. 2023;114:4535-4547 pubmed publisher |
Xu Z, Sziráki A, Lee J, Zhou W, Cao J. Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens. Nat Biotechnol. 2023;: pubmed publisher |
Shorthouse D, Zhuang L, Rahrmann E, Kosmidou C, Wickham Rahrmann K, Hall M, et al. KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas. Life Sci Alliance. 2023;6: pubmed publisher |
Childress K, Cencer C, Tyska M, Lacy D. Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB. MBio. 2023;14:e0185723 pubmed publisher |
Nano P, Fazzari E, Azizad D, Nguyen C, Wang S, Kan R, et al. A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification. bioRxiv. 2023;: pubmed publisher |
Ensink E, Jordan T, Medeiros H, Thurston G, Pardal A, Yu L, et al. Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells. bioRxiv. 2023;: pubmed publisher |
Rivera J, Weng W, Huang H, Rao S, Herring B, Arnold D. ATLAS: A rationally designed anterograde transsynaptic tracer. bioRxiv. 2023;: pubmed publisher |
Chan W, Williams J, Sorathia K, Pray B, Abusaleh K, Bian Z, et al. A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models. Exp Hematol Oncol. 2023;12:79 pubmed publisher |
Liu T, Fan M, Xie X, Shu Q, Du X, Qi L, et al. Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression. J Transl Med. 2023;21:656 pubmed publisher |
Rohatgi N, Zou W, Li Y, Cho K, Collins P, Tycksen E, et al. BAP1 promotes osteoclast function by metabolic reprogramming. Nat Commun. 2023;14:5923 pubmed publisher |
Wang F, Gao Y, Xue S, Zhao L, Jiang H, Zhang T, et al. SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity. Nat Commun. 2023;14:5917 pubmed publisher |
Bolz S, Kaempf N, Puchkov D, Krauss M, Russo G, Soykan T, et al. Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis. Neuron. 2023;111:3765-3774.e7 pubmed publisher |
Ren R, Hua Y, Wang H. Protocol to capture transcription factor-mediated 3D chromatin interactions using affinity tag-based BL-HiChIP. STAR Protoc. 2023;4:102589 pubmed publisher |
Barik G, Sahay O, Mukhopadhyay A, Manne R, Islam S, Roy A, et al. FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. Cell Death Dis. 2023;14:623 pubmed publisher |
Kugler E, Madiwale S, Yong D, Thoms J, Birger Y, Sykes D, et al. The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Nat Commun. 2023;14:5871 pubmed publisher |
Dharmasri P, Levy A, Blanpied T. Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons. bioRxiv. 2023;: pubmed publisher |
Tian L, Li H, Zhao P, Liu Y, Lu Y, Zhong R, et al. C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages. iScience. 2023;26:107771 pubmed publisher |
Mukhopadhyay S, Huang H, Lin Z, Ranieri M, Li S, Sahu S, et al. Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy. Cancer Res. 2023;83:4095-4111 pubmed publisher |
Lee W, Zamudio Ochoa A, Buchel G, Podlesniy P, Martí Gutiérrez N, Puigr xf2 s M, et al. Molecular basis for maternal inheritance of human mitochondrial DNA. Nat Genet. 2023;55:1632-1639 pubmed publisher |
Belliveau N, Footer M, Akdo x1e7 an E, van Loon A, Collins S, Theriot J. Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils. Nat Commun. 2023;14:5770 pubmed publisher |
Yu D, Zhao J, Lee E, Kim D, Mahapatra R, Rose E, et al. GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. J Clin Invest. 2023;133: pubmed publisher |
Yousefi Najafabadi Z, Mehmandoostli Z, Asgari Y, Kaboli S, Falak R, Kardar G. Reversing T Cell Exhaustion by Converting Membrane PD-1 to Its Soluble form in Jurkat Cells; Applying The CRISPR/Cas9 Exon Skipping Strategy. Cell J. 2023;25:633-644 pubmed publisher |
Pan H, Cheng X, Rodr xed guez P, Zhang X, Chung I, Jin V, et al. An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing. J Biol Chem. 2023;299:105259 pubmed publisher |
Malnar x10c rnigoj M, x10c er x10d ek U, Yin X, Ho M, Repič Lampret B, Neumann M, et al. Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA. Nat Commun. 2023;14:5764 pubmed publisher |
Cui Y, Miao Y, Cao L, Guo L, Cui Y, Yan C, et al. Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. Nat Commun. 2023;14:5740 pubmed publisher |
K xf6 rner M, Meyer S, Marincola G, Kern M, Grimm C, Schuelein Voelk C, et al. The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. elife. 2023;12: pubmed publisher |
Drumond Bock A, Wang L, Wang L, Cybula M, Rostworowska M, Kinter M, et al. Increased expression of BRD4 isoforms long (BRD4-L) and short (BRD4-S) promotes chemotherapy resistance in high-grade serous ovarian carcinoma. Genes Cancer. 2023;14:56-76 pubmed publisher |
Sadhu R, Hernandez Padilla C, Eisenbach Y, Peni x10d S, Zhang L, Vishwasrao H, et al. Experimental and theoretical model for the origin of coiling of cellular protrusions around fibers. Nat Commun. 2023;14:5612 pubmed publisher |
Witkowski T, Li B, Andersen J, Kumar B, Mroz E, Rocco J. Y-27632 acts beyond ROCK inhibition to maintain epidermal stem-like cells in culture. J Cell Sci. 2023;136: pubmed publisher |
Kim H, Grimes S, Chen T, Sathe A, Lau B, Hwang G, et al. Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells. Nat Biotechnol. 2023;: pubmed publisher |
Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, et al. A split and inducible adenine base editor for precise in vivo base editing. Nat Commun. 2023;14:5573 pubmed publisher |
Grillo G, Keshavarzian T, Linder S, Arlidge C, Mout L, Nand A, et al. Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer. Cancer Discov. 2023;13:2470-2487 pubmed publisher |
Chen Z, Will R, Kim S, Busch M, D xfc nker N, Dammann P, et al. Novel Function of Cancer Stem Cell Marker ALDH1A3 in Glioblastoma: Pro-Angiogenesis through Paracrine PAI-1 and IL-8. Cancers (Basel). 2023;15: pubmed publisher |
Neely V, Manchikalapudi A, Nguyen K, Dalton K, Hu B, Koblinski J, et al. Targeting Oncogenic Mutant p53 and BCL-2 for Small Cell Lung Cancer Treatment. Int J Mol Sci. 2023;24: pubmed publisher |
Lee T, Hunter F, Tsai P, Print C, Wilson W, Jamieson S. Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens. Cancer Gene Ther. 2023;30:1610-1623 pubmed publisher |
McAloney C, Makkawi R, Budhathoki Y, Cannon M, Franz E, Gross A, et al. Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. Cell Oncol (Dordr). 2023;: pubmed publisher |
Dou Y, Chen R, Liu S, Lee Y, Jing J, Liu X, et al. Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy. Nat Commun. 2023;14:5461 pubmed publisher |
Lethier M, Huard K, Hons M, Favier A, Brutscher B, Boeri Erba E, et al. Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface. Life Sci Alliance. 2023;6: pubmed publisher |
Xu D, Forbes A, Cohen S, Palladino A, Karadimitriou T, Khurana E. Recapitulation of patient-specific 3D chromatin conformation using machine learning. Cell Rep Methods. 2023;3:100578 pubmed publisher |
Son G, Tu N, Santi M, Loya Lopéz S, Souza Bomfim G, Vinu M, et al. The Ca2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain. Sci Signal. 2023;16:eadf9535 pubmed publisher |
Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang J, et al. SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1. J Clin Invest. 2023;133: pubmed publisher |
S xe4 nger C, Cernakova M, WIETECHA M, Garau Paganella L, Labouesse C, Dudaryeva O, et al. Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress. Sci Adv. 2023;9:eadh9219 pubmed publisher |
Li K, Cardenas Lizana P, Kellner A, Yuan Z, Ahn E, Lyu J, et al. Mechanical force regulates ligand binding and function of PD-1. bioRxiv. 2023;: pubmed publisher |
Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, et al. Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. bioRxiv. 2023;: pubmed publisher |
Van Scoyk A, Antelope O, Franzini A, Ayer D, Peterson R, Pomicter A, et al. Bioluminescence Assay of Lysine Deacylase Sirtuin Activity. bioRxiv. 2023;: pubmed publisher |
Montezano A, Camargo L, Mary S, Neves K, Rios F, Stein R, et al. SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Sci Rep. 2023;13:14086 pubmed publisher |
Zhang T, Leng Y, Duan M, Li Z, Ma Y, Huang C, et al. LncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells. Discov Oncol. 2023;14:157 pubmed publisher |
Liang T, Xiao S, Wu Z, Lv X, Liu S, Hu M, et al. Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein. Viruses. 2023;15: pubmed publisher |
Tsai P, Shui B, Lee S, Liu Y, Qu Y, Cheng C, et al. Ado-Mediated Depletion of Taurine Impairs Mitochondrial Respiratory Capacity and Alters the Chromatin Landscape of Inguinal Adipose Tissue. Nutrients. 2023;15: pubmed publisher |
Yang S, Wang Y, Yu F, Cheng R, Zhang Y, Zhou D, et al. Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Nat Commun. 2023;14:5186 pubmed publisher |
Gsottberger F, Meier C, Ammon A, Parker S, Wendland K, George R, et al. Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response. Cell Death Dis. 2023;14:561 pubmed publisher |
Einig E, Jin C, Andrioletti V, Macek B, Popov N. RNAPII-dependent ATM signaling at collisions with replication forks. Nat Commun. 2023;14:5147 pubmed publisher |
Hu Y, Liu L, Chen Y, Zhang X, Zhou H, Hu S, et al. Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia. Nat Commun. 2023;14:5179 pubmed publisher |
Halawani D, Wang Y, Ramakrishnan A, Estill M, He X, Shen L, et al. Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons. Nat Commun. 2023;14:5165 pubmed publisher |
Tejedor J, Pe xf1 arroya A, Gancedo Verdejo J, Santamarina Ojeda P, P xe9 rez R, L xf3 pez Tamargo S, et al. CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer. Clin Epigenetics. 2023;15:133 pubmed publisher |
Weng M, Hu H, Graus M, Tan D, Gao Y, Ren S, et al. An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming. Sci Adv. 2023;9:eadh2501 pubmed publisher |
Sugiokto F, Saiada F, Zhang K, Li R. SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication. bioRxiv. 2023;: pubmed publisher |
Ramezani M, Bauman J, Singh A, Weisbart E, Yong J, Lozada M, et al. A genome-wide atlas of human cell morphology. bioRxiv. 2023;: pubmed publisher |
Castillo Castrejón M, Sankofi B, Murguia S, Udeme A, Cen H, Xia Y, et al. FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer. Breast Cancer Res. 2023;25:99 pubmed publisher |
Hu H, Ho D, Tan D, MacCarthy C, Yu C, Weng M, et al. Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17. Nucleic Acids Res. 2023;51:8934-8956 pubmed publisher |
Worboys J, Vowell K, Hare R, Ambrose A, Bertuzzi M, Conner M, et al. TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nat Commun. 2023;14:5016 pubmed publisher |
Kuang M, Zhao Y, Yu H, Li S, Liu T, Chen L, et al. XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility. Sci Adv. 2023;9:eadg5211 pubmed publisher |
Duplaquet L, Li Y, Booker M, Xie Y, Olsen S, Patel R, et al. KDM6A epigenetically regulates subtype plasticity in small cell lung cancer. Nat Cell Biol. 2023;25:1346-1358 pubmed publisher |
Enders L, Siklos M, Borggr xe4 fe J, Gaussmann S, Koren A, Malik M, et al. Pharmacological perturbation of the phase-separating protein SMNDC1. Nat Commun. 2023;14:4504 pubmed publisher |
Han K, Singh K, Meadows A, Sharma R, Hassanzadeh S, Wu J, et al. Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects. Cell Rep Med. 2023;4:101157 pubmed publisher |
Contreras N, Rold xe1 n J, Castillo D. Novel competitive enzyme-linked immunosorbent assay for the detection of the high-risk Human Papillomavirus 18 E6 oncoprotein. PLoS ONE. 2023;18:e0290088 pubmed publisher |
Lara Astiaso D, Go xf1 i Salaverri A, Mendieta Esteban J, Narayan N, Del Valle C, Gross T, et al. In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis. Nat Genet. 2023;55:1542-1554 pubmed publisher |
Perales Linares R, Leli N, Mohei H, Beghi S, Rivera O, Kostopoulos N, et al. Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance. Cancer Res. 2023;83:3562-3576 pubmed publisher |
Nikolatou K, Sandilands E, Rom xe1 n Fern xe1 ndez A, Cumming E, Freckmann E, Lilla S, et al. PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO J. 2023;42:e113987 pubmed publisher |
Lock I, Leisenring N, Floyd W, Xu E, Luo L, Ma Y, et al. Mis-splicing Drives Loss of Function of p53E224D Point Mutation. bioRxiv. 2023;: pubmed publisher |
de Caestecker C, Macara I. A Size Filter Regulates Apical Protein Sorting. Res Sq. 2023;: pubmed publisher |
Park J, Luo Y, Park J, Kim S, Hong Y, Lim Y, et al. Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages. Sci Rep. 2023;13:13132 pubmed publisher |
Huang Y, Drakul A, Sidhu J, Rauwolf K, Kim J, Bornhauser B, et al. MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling. SLAS Discov. 2023;: pubmed publisher |
Chen W, Wu C, Liu Y, Zhuo G, Wang Y, Chen Y, et al. Elafin as a Prognostic Marker in Esophageal Squamous Cell Carcinoma: A Pilot Study Using Three-Dimensional Imaging and Genomic Profiling. Cancers (Basel). 2023;15: pubmed publisher |
Klotz D, Schwarz F, Dubrovska A, Schuster K, Theis M, Kr xfc ger A, et al. Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer. Cancers (Basel). 2023;15: pubmed publisher |
Wu J, Wang X, Zhang M, Mathews P, Kang Y. RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect. Cells. 2023;12: pubmed publisher |
Venkatarangan V, Zhang W, Yang X, Thoene J, Hahn S, Li M. ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine. J Clin Invest. 2023;133: pubmed publisher |
Zagnoli Vieira G, Brazina J, Van Den Bogaert K, Huybrechts W, Molenaers G, Caldecott K, et al. Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. Hum Genet. 2023;142:1417-1427 pubmed publisher |
Leighton G, Shang S, Hageman S, Ginder G, Williams D. Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing. Proc Natl Acad Sci U S A. 2023;120:e2307287120 pubmed publisher |
Liu M, Jin S, Agabiti S, Jensen T, Yang T, Radda J, et al. A genome-wide single-cell 3D genome atlas of lung cancer progression. bioRxiv. 2023;: pubmed publisher |
Lerner E, Woroniecka K, D Anniballe V, Wilkinson D, Mohan A, Lorrey S, et al. CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D-NKG2DL axis. Nat Cancer. 2023;4:1258-1272 pubmed publisher |
Zhou H, Zhou L, Guan Q, Hou X, Wang C, Liu L, et al. Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells. Commun Biol. 2023;6:805 pubmed publisher |
Koban F, Freissmuth M. The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. EMBO Rep. 2023;24:e53408 pubmed publisher |
García Carpio I, Braun V, Weiler E, Leone M, Ni xf1 erola S, Barco A, et al. Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance. EMBO J. 2023;:e113510 pubmed publisher |
Zhao P, Sun L, Zhao C, Malik S. PD1 is transcriptionally regulated by LEF1 in mature T cells. Immunobiology. 2023;228:152708 pubmed publisher |
Wang C, Yang K, Liu X, Wang S, Song M, Belmonte J, et al. MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer. Research (Wash D C). 2023;6:0192 pubmed publisher |
Cox J, Jennings M, Lenahan C, Manion M, Courville S, Blazeck J. Rational engineering of an improved adenosine deaminase 2 enzyme for weaponizing T-cell therapies. Immunooncol Technol. 2023;19:100394 pubmed publisher |
Matsuda K, Hirayama D, Hino N, Kuno S, Sakaue Sawano A, Miyawaki A, et al. Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration. J Cell Sci. 2023;: pubmed publisher |
Zeghal M, Matte K, Venes A, Patel S, Laroche G, Sarvan S, et al. Development of a V5-tag-directed nanobody and its implementation as an intracellular biosensor of GPCR signalling. J Biol Chem. 2023;:105107 pubmed publisher |
Slepak T, Guyot M, Walters W, Eichberg D, Ivan M. Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion and proliferation. J Biol Chem. 2023;:105105 pubmed publisher |
Kanai A, Nishida Y, Iwamoto T, Yokota M, Aoyama S, Ueki K, et al. Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter. Biochem Biophys Res Commun. 2023;676:132-140 pubmed publisher |
Fan T, Winnike J, Al Attar A, Belshoff A, Lorkiewicz P, Tan J, et al. Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer. Metabolites. 2023;13: pubmed publisher |
Shamloo S, Kloetgen A, Petroulia S, Hockemeyer K, Sievers S, Tsirigos A, et al. Integrative CRISPR Activation and Small Molecule Inhibitor Screening for lncRNA Mediating BRAF Inhibitor Resistance in Melanoma. Biomedicines. 2023;11: pubmed publisher |
Duan Y, Chen X, Zhu R, Jia Y, Huang X, Zhang M, et al. High-throughput functional dissection of noncoding SNPs with biased allelic enhancer activity for insulin resistance-relevant phenotypes. Am J Hum Genet. 2023;: pubmed publisher |
Prislusky M, Lam J, Contreras V, Ng M, Chamberlain M, Fields M, et al. The Septin Cytoskeleton is Required for Plasma Membrane Repair. bioRxiv. 2023;: pubmed publisher |
Rashidfarrokhi A, Pillai R, Hao Y, Wu W, Karadal Ferrena B, Dimitriadoy S, et al. Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth. bioRxiv. 2023;: pubmed publisher |
Li J, Vasciaveo A, Karagiannis D, Sun Z, Chen X, Socciarelli F, et al. NSD2 maintains lineage plasticity and castration-resistance in neuroendocrine prostate cancer. bioRxiv. 2023;: pubmed publisher |
Ren X, Yang H, Nierenberg J, Sun Y, Chen J, Beaman C, et al. High throughput PRIME editing screens identify functional DNA variants in the human genome. bioRxiv. 2023;: pubmed publisher |
Lin C, Chang T, Wang Y, Guo L, Gao Y, Bikorimana E, et al. Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Res Sq. 2023;: pubmed publisher |
Dolan M, Therrien M, Jereb S, Kamath T, Gazestani V, Atkeson T, et al. Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nat Immunol. 2023;24:1382-1390 pubmed publisher |
Kim Y, Kim J, Lee D, Choi J, Park J, Lee H, et al. T Cells Expressing CAR Equipped With Extracellular Domain of BTLA Are Effective Against HVEM-over-expressing Melanoma Cell Lines. Anticancer Res. 2023;43:3419-3427 pubmed publisher |
Boys I, Johnson A, Quinlan M, Kranzusch P, Elde N. Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity. Cell Rep. 2023;42:112878 pubmed publisher |
Sako H, Youssef M, Elisseeva O, Akimoto T, Suzuki K, Ushida T, et al. microRNAs slow translating ribosomes to prevent protein misfolding in eukaryotes. EMBO J. 2023;:e112469 pubmed publisher |
Kumar S, Stainer A, Dubrulle J, Simpkins C, Cooper J. Cas phosphorylation regulates focal adhesion assembly. elife. 2023;12: pubmed publisher |
Li H, Bartke R, Zhao L, Verma Y, Horacek A, Rechav Ben Natan A, et al. Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells. Nat Biomed Eng. 2023;: pubmed publisher |
Sharma R, Earla B, Baidoo K, Zeiger M, Madigan J, Escorcia F, et al. Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model. Mol Cancer Ther. 2023;: pubmed publisher |
Steadman K, You S, Srinivas D, Mouakkad L, Yan Y, Kim M, et al. Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3' untranslated region. Front Cell Dev Biol. 2023;11:1206259 pubmed publisher |
Long Y, Ren Y, Wei Q, Mobet Y, Liu Y, Zhao H, et al. NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. Int J Med Sci. 2023;20:1079-1090 pubmed publisher |
Wu C, Yang Y, Lin Y, Shu L, Cheng Y, Liu H, et al. The anti-SARS-CoV-2 effect and mechanism of Chiehyuan herbal oral protection solution. Heliyon. 2023;9:e17701 pubmed publisher |
Joshi P, Sadre S, Guo X, McCoy J, Mootha V. Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. J Biol Chem. 2023;:105075 pubmed publisher |
Ding Z, Yang J, Wu B, Wu Y, Guo F. Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells. Cancer Metab. 2023;11:10 pubmed publisher |
Zhu S, Tao M, Li Y, Wang X, Zhao Z, Liu Y, et al. H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection. J Neuroinflammation. 2023;20:168 pubmed publisher |
Nasehi L, Abdolhossein Zadeh B, Rahimi H, Hossein Ghahremani M. Radio-immunotherapy by 188Re-antiCD20 and stable silencing of IGF-IR in Raji cells, new insight in treatment of lymphoma. Gene. 2023;882:147638 pubmed publisher |
Zhang X, Yao J, Li X, Niu N, Liu Y, Hajek R, et al. Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer. Sci Adv. 2023;9:eadf7195 pubmed publisher |
Hertz E, Vega I, Kruse T, Wang Y, Hendriks I, Bizard A, et al. The SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure. Nat Struct Mol Biol. 2023;: pubmed publisher |
Peng W, Schr xf6 der L, Song P, Wong Y, Krainc D. Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease. Sci Adv. 2023;9:eadh3347 pubmed publisher |
Wei H, Wang H, Wang G, Qu L, Jiang L, Dai S, et al. Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun. 2023;14:4300 pubmed publisher |
Ai Y, Wang W, Liu F, Fang W, Chen H, Wu L, et al. Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. Cell Res. 2023;: pubmed publisher |
Vo M, Choi C, Choi Y. The mitophagy receptor NIX induces vIRF-1 oligomerization and interaction with GABARAPL1 for the promotion of HHV-8 reactivation-induced mitophagy. PLoS Pathog. 2023;19:e1011548 pubmed publisher |
Haagsma J, Kolendowski B, Buensuceso A, Valdes Y, DiMattia G, Shepherd T. Gain-of-function p53R175H blocks apoptosis in a precursor model of ovarian high-grade serous carcinoma. Sci Rep. 2023;13:11424 pubmed publisher |
Moriyama S, Anraku Y, Taminishi S, Adachi Y, Kuroda D, Kita S, et al. Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants. Nat Commun. 2023;14:4198 pubmed publisher |
Cuevas Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, et al. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Sci Adv. 2023;9:eadf4766 pubmed publisher |
Hu G, Huang N, Zhang J, Zhang D, Wang S, Zhang Y, et al. LKB1 loss promotes colorectal cancer cell metastasis through regulating TNIK expression and actin cytoskeleton remodeling. Mol Carcinog. 2023;: pubmed publisher |
Yeh D, Liu C, Hernández J, Tahara S, Tsukamoto H, Machida K. Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. iScience. 2023;26:107035 pubmed publisher |
Costa I, Effer B, Costa Silva T, Chen C, Ciccone M, Pessoa A, et al. Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line. Int J Mol Sci. 2023;24: pubmed publisher |
Zhang L, Jiang C, Zhong Y, Sun K, Jing H, Song J, et al. STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2. Nat Cell Biol. 2023;: pubmed publisher |
Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, et al. Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion. Nat Commun. 2023;14:4084 pubmed publisher |
Beatriz M, Rodrigues R, Vila xe7 a R, Egas C, Pinheiro P, Daley G, et al. Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons. Theranostics. 2023;13:3707-3724 pubmed publisher |
Hoshino H, Chen Y, Inoue D, Yoshida Y, Khoo K, Akama T, et al. Expression of low-sulfated keratan sulfate in non-mucinous ovarian carcinoma. Glycobiology. 2023;: pubmed publisher |
Ju X, Wang Z, Wang P, Ren W, Yu Y, Yu Y, et al. SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense. MBio. 2023;:e0137323 pubmed publisher |
Meyer L, Koschade S, Vischedyk J, Thoelken M, Gubas A, Wegner M, et al. Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. Autophagy. 2023;:1-15 pubmed publisher |
Yang J, Petty C, Dixon McDougall T, Lopez M, Tyshkovskiy A, Maybury Lewis S, et al. Chemically induced reprogramming to reverse cellular aging. Aging (Albany NY). 2023;15:5966-5989 pubmed publisher |
Geng F, Zhong Y, Su H, Lefai E, Magaki S, Cloughesy T, et al. SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells. Cell Rep. 2023;42:112790 pubmed publisher |
Alborzinia H, Chen Z, Yildiz U, Freitas F, Vogel F, Varga J, et al. LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. EMBO Mol Med. 2023;:e18014 pubmed publisher |
Neff R, Bosch Gutierrez A, Sun Y, Katsyv I, Song W, Wang M, et al. Dysfunction of ubiquitin protein ligase MYCBP2 leads to cell resilience in human breast cancers. NAR Cancer. 2023;5:zcad036 pubmed publisher |
Zhao P, Wang Y, Yu X, Nan Y, Liu S, Li B, et al. Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis. Front Med. 2023;: pubmed publisher |
Valakos D, Klagkou E, Kokkalis A, Polyzos A, Kyrilis F, Banos A, et al. Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity. PLoS ONE. 2023;18:e0288005 pubmed publisher |
Evans S, Shi D, Chavarha M, Plitt M, Taxidis J, Madruga B, et al. A positively tuned voltage indicator for extended electrical recordings in the brain. Nat Methods. 2023;20:1104-1113 pubmed publisher |
Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval A, Ozturk H, et al. Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Nat Commun. 2023;14:4057 pubmed publisher |
Beccano Kelly D, Cherubini M, Mousba Y, Cramb K, Giussani S, Caiazza M, et al. Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons. iScience. 2023;26:107044 pubmed publisher |
Pizzato H, Alonso Guallart P, Woods J, Johannesson B, Connelly J, Fehniger T, et al. Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers. bioRxiv. 2023;: pubmed publisher |
Pallaseni A, Peets E, Girling G, Crepaldi L, Kuzmin I, Raudvere U, et al. The interplay of DNA repair context with target sequence predictably biasses Cas9-generated mutations. bioRxiv. 2023;: pubmed publisher |
Praharaj P, Singh A, Patra S, Bhutia S. Co-targeting autophagy and NRF2 signaling triggers mitochondrial superoxide to sensitize oral cancer stem cells for cisplatin-induced apoptosis. Free Radic Biol Med. 2023;207:72-88 pubmed publisher |
Waddell G, Drew E, Rupp H, Hansen S. Mechanisms controlling membrane recruitment and activation of the autoinhibited SHIP1 inositol 5-phosphatase. J Biol Chem. 2023;:105022 pubmed publisher |
Romero Tejeda M, Fonoudi H, Weddle C, DeKeyser J, Lenny B, Fetterman K, et al. A novel transcription factor combination for direct reprogramming to a spontaneously contracting human cardiomyocyte-like state. J Mol Cell Cardiol. 2023;182:30-43 pubmed publisher |
Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye V, Wrobel A, et al. TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry. Cell. 2023;: pubmed publisher |
Reynolds L, Hernandez G, MacGowan D, Popescu C, Nouel D, Cuesta S, et al. Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice. Nat Commun. 2023;14:4035 pubmed publisher |
Wang R, Wang D, Bai X, Guo J, Xia S, Cheng Y, et al. Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma. Cell Death Discov. 2023;9:231 pubmed publisher |
Coppola V, Marino I, Warnken U, Falchi M, Pasquini L, Biffoni M, et al. The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8). Autophagy. 2023;:1-19 pubmed publisher |
Weidenauer K, Schmidt C, Rohde C, Pauli C, Blank M, Heid D, et al. The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia. Leukemia. 2023;: pubmed publisher |
Rampias T, Klinakis A. Using Sister Chromatid Exchange Assay to Detect Homologous Recombination Deficiency in Epigenetically Deregulated Urothelial Carcinoma Cells. Methods Mol Biol. 2023;2684:133-144 pubmed publisher |
Chen Y, Dufour C, Han L, Li T, Xia H, Giguere V. Hierarchical phosphorylation of HOXB13 by mTOR dictates its activity and oncogenic function in prostate cancer. Mol Cancer Res. 2023;: pubmed publisher |
Karimi T, Pan Z, Potaman V, Alt E. Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes. Cells. 2023;12: pubmed publisher |
Mishima E, Nakamura T, Zheng J, Zhang W, Mour xe3 o A, Sennhenn P, et al. DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Nature. 2023;619:E9-E18 pubmed publisher |
Kim H, Feng Y, Murad R, Poźniak J, Pelz C, Chen Y, et al. Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Sci Adv. 2023;9:eadf6621 pubmed publisher |
Rajabalee N, Siushansian H, Weerapura M, Berton S, Berbatovci F, Hooks B, et al. ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses. J Leukoc Biol. 2023;: pubmed publisher |
Zhang Z, Zhang M, Zhou J, Wang D. Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy. Br J Cancer. 2023;: pubmed publisher |
Wessels H, Stirn A, M xe9 ndez Mancilla A, Kim E, Hart S, Knowles D, et al. Prediction of on-target and off-target activity of CRISPR-Cas13d guide RNAs using deep learning. Nat Biotechnol. 2023;: pubmed publisher |
Yim Y, Pedrosa A, Wu X, Chinthalapudi K, Cheney R, Hammer J. Myosin 10 uses its MyTH4 and FERM domains differentially to support two aspects of spindle pole biology required for mitotic spindle bipolarity. bioRxiv. 2023;: pubmed publisher |
Griffin M, Thompson J, Xiao Y, Sweredoski M, Aksenfeld R, Jensen E, et al. Functional glycoproteomics by integrated network assembly and partitioning. bioRxiv. 2023;: pubmed publisher |
Kim I, Diamond M, Yuan S, Kemp S, Li Q, Lin J, et al. Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy. Res Sq. 2023;: pubmed publisher |
Pedro M, Lund K, Kang S, Chen T, Stuelten C, Porat Shliom N, et al. A GPCR screening in human keratinocytes identifies that the metabolite receptor HCAR3 controls epithelial proliferation, migration, and cellular respiration. bioRxiv. 2023;: pubmed publisher |
Yu Y, Cao W, Cheng F, Shi Z, Han L, Yi J, et al. FOXK2 amplification and overexpression promotes breast cancer development and chemoresistance. bioRxiv. 2023;: pubmed publisher |
Yoo H, La H, Park C, Yoo S, Lee H, Song H, et al. Common and distinct functions of mouse Dot1l in the regulation of endothelial transcriptome. Front Cell Dev Biol. 2023;11:1176115 pubmed publisher |
Zhang Y, Ramirez Martinez A, Chen K, McAnally J, Cai C, Durbacz M, et al. Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy. J Clin Invest. 2023;133: pubmed publisher |
Liu J, Min S, Kim D, Park J, Park E, Pei S, et al. Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemia. Leukemia. 2023;: pubmed publisher |
Canale F, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, et al. Proteomics of immune cells from liver tumors reveals immunotherapy targets. Cell Genom. 2023;3:100331 pubmed publisher |
Chen Z, Javed N, Moore M, Wu J, Sun G, Vinyard M, et al. Integrative dissection of gene regulatory elements at base resolution. Cell Genom. 2023;3:100318 pubmed publisher |
Leoni C, Bataclan M, Ito Kureha T, Heissmeyer V, Monticelli S. The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells. Nat Commun. 2023;14:3862 pubmed publisher |
Tang Y, Thiess L, Weiler S, T xf3 th M, Rose F, Merker S, et al. α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration. Cell Commun Signal. 2023;21:162 pubmed publisher |
Negoita F, Addinsall A, Hellberg K, Bringas C, Hafen P, Sermersheim T, et al. CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle. Mol Metab. 2023;75:101761 pubmed publisher |
Wang Z, Pan Q, Ma L, Zhao J, McIntosh F, Liu Z, et al. Anthracyclines inhibit SARS-CoV-2 infection. Virus Res. 2023;334:199164 pubmed publisher |
Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, et al. A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Protein Cell. 2023;: pubmed publisher |
Chen L, Li Y, Chen Y. KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2. iScience. 2023;26:106914 pubmed publisher |
Kaba M, Carreras Sureda A, Nunes Hasler P, Demaurex N. The lipid transfer proteins Nir2 and Nir3 sustain phosphoinositide signaling and actin dynamics during phagocytosis. J Cell Sci. 2023;136: pubmed publisher |
Radion E, Mukhin V, Kholodova A, Vladimirov I, Alsaeva D, Zhdanova A, et al. Functional Characteristics of Serum Anti-SARS-CoV-2 Antibodies against Delta and Omicron Variants after Vaccination with Sputnik V. Viruses. 2023;15: pubmed publisher |
Borkowska P, Morys J, Zielińska A, Kowalski J. Effects of the Co-Overexpression of the BCL and BDNF Genes on the Gamma-Aminobutyric Acid-Ergic Differentiation of Wharton's-Jelly-Derived Mesenchymal Stem Cells. Biomedicines. 2023;11: pubmed publisher |
Shimizu Y, Bandaru S, Hara M, Young S, Sano T, Usami K, et al. An RNA-immunoprecipitation via CRISPR/dCas13 reveals an interaction between the SARS-CoV-2 5'UTR RNA and the process of human lipid metabolism. Sci Rep. 2023;13:10413 pubmed publisher |
Perelli L, Carbone F, Zhang L, Huang J, Le C, Khan H, et al. Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer. Nat Cancer. 2023;4:984-1000 pubmed publisher |
Fernandez Garcia E, Paudel U, Noji M, Bowman C, Rustgi A, Pitarresi J, et al. The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation. Front Cell Dev Biol. 2023;11:1082213 pubmed publisher |
Lopez E, Hidalgo S, Roa E, G xf3 mez J, Hermansen Truan C, Sanders E, et al. Preclinical evaluation of chimeric antigen receptor T cells targeting the carcinoembryonic antigen as a potential immunotherapy for gallbladder cancer. Oncoimmunology. 2023;12:2225291 pubmed publisher |
Page A, Delles M, N xe8 gre D, Costa C, Fusil F, Cosset F. Engineering B cells with customized therapeutic responses using a synthetic circuit. Mol Ther Nucleic Acids. 2023;33:1-14 pubmed publisher |
Rudd J, Maity S, Grunkemeyer J, Snyder J, Lovas S, Hansen L. Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4. J Biol Chem. 2023;299:104945 pubmed publisher |
Liu H, Chen C, Liao S, Sohaii D, Cruz C, Burdo T, et al. Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells. Mol Ther Nucleic Acids. 2023;32:1010-1025 pubmed publisher |
Cruz M, Gonzalez Y, V xe9 lez Toro J, Karimzadeh M, Rubbo A, Morris L, et al. Micronutrient optimization for tissue engineered articular cartilage production of type II collagen. Front Bioeng Biotechnol. 2023;11:1179332 pubmed publisher |
Wang K, Pan Y, Wang D, Yuan Y, Li M, Chen Y, et al. Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry. Virol Sin. 2023;: pubmed publisher |
Song Z, Zhang G, Huang S, Liu Y, Li G, Zhou X, et al. PE-STOP: A versatile tool for installing nonsense substitutions amenable for precise reversion. J Biol Chem. 2023;299:104942 pubmed publisher |
Lin L, Wang X, Chen Z, Deng T, Yan Y, Dong W, et al. TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1. PLoS Pathog. 2023;19:e1011472 pubmed publisher |
Onda M, Ota A, Ito K, Ono T, Karnan S, Kato M, et al. Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma. Cancer Med. 2023;: pubmed publisher |
Benedetti E, Liu E, Tang C, Kuo F, Buyukozkan M, Park T, et al. A multimodal atlas of tumour metabolism reveals the architecture of gene-metabolite covariation. Nat Metab. 2023;5:1029-1044 pubmed publisher |
Martin J, Terry S, Gale J, Dawson S. The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition. J Cell Sci. 2023;136: pubmed publisher |
Rafnsdottir S, Jang K, Halldorsdottir S, Tomasdottir A, Vinod M, M xf6 ller K, et al. SMYD5 is a novel epigenetic gatekeeper of the mild hypothermia response. bioRxiv. 2023;: pubmed publisher |
Nelson A, Cicardi M, Markandaiah S, Han J, Philp N, Welebob E, et al. Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes. bioRxiv. 2023;: pubmed publisher |
Gurler G, Belder N, Beker M, Sever Bahcekapili M, Uruk G, Kilic E, et al. Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity. Fluids Barriers CNS. 2023;20:47 pubmed publisher |
Zhang J, Ye Z, Br xe4 utigam L, Chakraborty P, Luo Z, Culpepper J, et al. A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression. J Biol Chem. 2023;299:104920 pubmed publisher |
Li C, Wilborn J, Pittman S, Daw J, Alonso P xe9 rez J, D xed az Manera J, et al. Comprehensive functional characterization of SGCB coding variants predicts pathogenicity in limb-girdle muscular dystrophy type R4/2E. J Clin Invest. 2023;133: pubmed publisher |
Issa H, Bhayadia R, Winkler R, Swart L, Heckl D, Klusmann J. Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias. Leukemia. 2023;37:1583-1587 pubmed publisher |
Lenza M, Egia Mendikute L, Anto xf1 ana Vildosola A, Soares C, Coelho H, Corzana F, et al. Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun. 2023;14:3496 pubmed publisher |
Yiu S, Zerbe C, Vanderwall D, Huttlin E, Weekes M, Gewurz B. An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation. Mol Cell. 2023;83:2367-2386.e15 pubmed publisher |
Zheng W, Zhu T, Tang L, Li Z, Jiang G, Huang X. Inhalable CAR-T cell-derived exosomes as paclitaxel carriers for treating lung cancer. J Transl Med. 2023;21:383 pubmed publisher |
Sych T, Schlegel J, Barriga H, Ojansivu M, Hanke L, Weber F, et al. High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler. Nat Biotechnol. 2023;: pubmed publisher |
Xie T, Liu P, Wu X, Dong F, Zhang Z, Yue J, et al. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nat Commun. 2023;14:3475 pubmed publisher |
Lu Y, Ma W, Ren G, Liu X, Li Y, Wang T, et al. VPS37C facilitates erythroid differentiation by promoting EKLF stability. Biochem Biophys Res Commun. 2023;671:229-235 pubmed publisher |
Tian C, Zhou J, Li X, Gao Y, Wen Q, Kang X, et al. Impaired histone inheritance promotes tumor progression. Nat Commun. 2023;14:3429 pubmed publisher |
Artico L, Ruas J, Teixeira J xfa nior J, Migita N, Seguchi G, Shi X, et al. IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis. Int J Mol Sci. 2023;24: pubmed publisher |
Garc xed a Mart xed nez K, Chen J, Jones J, Woo A, Aucapina A, Brito I, et al. Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response. bioRxiv. 2023;: pubmed publisher |
Gordon E, Wright C, James M, Cooper S. Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance. BMC Cancer. 2023;23:524 pubmed publisher |
Bharathan N, Giang W, Hoffman C, Aaron J, Khuon S, Chew T, et al. Architecture and dynamics of a desmosome-endoplasmic reticulum complex. Nat Cell Biol. 2023;25:823-835 pubmed publisher |
Esposito R, Lanz xf3 s A, Uroda T, Ramnarayanan S, B xfc chi I, Polidori T, et al. Tumour mutations in long noncoding RNAs enhance cell fitness. Nat Commun. 2023;14:3342 pubmed publisher |
Wu X, Azizan E, Goodchild E, Garg S, Hagiyama M, Cabrera C, et al. Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. Nat Genet. 2023;55:1009-1021 pubmed publisher |
Liang Z, Goradia A, Walkley C, Heraud Farlow J. Generation of a new Adar1p150 -/- mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis. RNA. 2023;29:1325-1338 pubmed publisher |
Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Fay E, et al. Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. PLoS Biol. 2023;21:e3002144 pubmed publisher |
Yan R, Moresco P, Gegenhuber B, Fearon D. T cell-Mediated Development of Stromal Fibroblasts with an Immune-Enhancing Chemokine Profile. Cancer Immunol Res. 2023;:OF1-OF11 pubmed publisher |
Folcher A, Gordienko D, Iamshanova O, Bokhobza A, Shapovalov G, Kannancheri Puthooru D, et al. NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness. EMBO J. 2023;42:e112198 pubmed publisher |
Ju X, Yu Y, Ren W, Dong L, Meng X, Deng H, et al. The PRMT5/WDR77 complex restricts hepatitis E virus replication. PLoS Pathog. 2023;19:e1011434 pubmed publisher |
Mendez Ruiz S, Chalk A, Goradia A, Heraud Farlow J, Walkley C. Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo. NAR Cancer. 2023;5:zcad023 pubmed publisher |
Wang Y, Yu Y, Yang W, Wu L, Yang Y, Lu Q, et al. SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence. Stem Cells Int. 2023;2023:7367854 pubmed publisher |
Cui W, Huang Z, Jin S, Johnson J, Lau K, Hostetter G, et al. Deficiency of the Polycomb protein RYBP and TET methylcytosine oxidases promotes extensive CpG island hypermethylation and malignant transformation. Cancer Res. 2023;: pubmed publisher |
Liu W, Zeng Y, Huang L, Zhang X, Bi L, Fan W, et al. RHOJ as a novel mechanosensitive modulator of endothelial inflammation. Biochem Biophys Res Commun. 2023;670:36-46 pubmed publisher |
Pablo J, Cornett S, Wang L, Jo S, Br xfc nger T, Budnik N, et al. Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing. Cell Rep. 2023;42:112563 pubmed publisher |
Kuiper J, Krause J, Potgeter L, Adrian J, Hauck C. A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis. J Cell Sci. 2023;136: pubmed publisher |
Strating E, Verhagen M, Wensink E, D xfc nnebach E, Wijler L, Aranguren I, et al. Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer. Front Immunol. 2023;14:1053920 pubmed publisher |
Liu S, Sun D, Butler R, Rawlins E. RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells. Development. 2023;150: pubmed publisher |
Mazouzi A, Moser S, Abascal F, van den Broek B, Del Castillo Velasco Herrera M, van der Heijden I, et al. FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks. Sci Adv. 2023;9:eadf4409 pubmed publisher |
Wollenzien H, Tecleab Y, Szczepaniak Sloane R, Restaino A, Kareta M. Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer. Mol Cancer Res. 2023;: pubmed publisher |
Renauer P, Park J, Bai M, Acosta A, Lee W, Lin G, et al. Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function. Cancer Immunol Res. 2023;: pubmed publisher |
Petersen J, Englmaier L, Artemov A, Poverennaya I, Mahmoud R, Bouderlique T, et al. A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Nat Commun. 2023;14:3092 pubmed publisher |
Levis H, Weston J, Austin B, Larsen B, Ginley Hidinger M, Gullbrand S, et al. Multiplex gene editing to promote cell survival using low-pH clustered regularly interspaced short palindromic repeats activation (CRISPRa) gene perturbation. Cytotherapy. 2023;: pubmed publisher |
Zhang F, Wu Z, Yu B, Ning Z, Lu Z, Li L, et al. ATP13A2 activates the pentose phosphate pathway to promote colorectal cancer growth though TFEB-PGD axis. Clin Transl Med. 2023;13:e1272 pubmed publisher |
Kaipa J, Krasnoselska G, Owens R, van den Heuvel J. Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells. Biomolecules. 2023;13: pubmed publisher |
Wang Y, Zhang H, La Ferlita A, Sp N, Goryunova M, Sarchet P, et al. Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity. Oncogenesis. 2023;12:30 pubmed publisher |
Shapiro D, Zacharias N, Tripathi D, Karki M, Bertocchio J, Soeung M, et al. Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy. Clin Transl Med. 2023;13:e1267 pubmed publisher |
Yu L, Wang Y, Xiao J, Shen Q, Chi S, Gao Y, et al. Dysregulation of iron homeostasis by TfR-1 renders EZH2 wild type diffuse large B-cell lymphoma resistance to EZH2 inhibition. Acta Pharmacol Sin. 2023;: pubmed publisher |
Nieminuszczy J, Martin P, Broderick R, Krwawicz J, Kanellou A, Mocanu C, et al. Actin nucleators safeguard replication forks by limiting nascent strand degradation. Nucleic Acids Res. 2023;51:6337-6354 pubmed publisher |
Lain x161 x10d ek D, Golob Urbanc A, Mikoli x10d V, Pantovi x107 x17d alig J, Malen x161 ek x, Jerala R. Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor. Mol Ther Oncolytics. 2023;29:77-90 pubmed publisher |
Inglis A, Guna A, G xe1 lvez Merch xe1 n x, Pal A, Esantsi T, Keys H, et al. Coupled protein quality control during nonsense-mediated mRNA decay. J Cell Sci. 2023;136: pubmed publisher |
Waryah C, Cursons J, Foroutan M, Pflueger C, Wang E, Molania R, et al. Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer. Adv Sci (Weinh). 2023;:e2301802 pubmed publisher |
Glover R, Schwardt N, Leano S, Sanchez M, Thomason M, Olive A, et al. A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of Listeria monocytogenes infection. PLoS Pathog. 2023;19:e1011058 pubmed publisher |
Sun X, Eastman G, Shi Y, Saibaba S, Oliveira A, Lukens J, et al. Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers. bioRxiv. 2023;: pubmed publisher |
Guerrero Santoro J, Morizane M, Oh S, Mishima T, Goff J, Bildirici I, et al. The lipase cofactor CGI58 controls placental lipolysis. JCI Insight. 2023;8: pubmed publisher |
Rosen B, Li Q, Cho H, Liu D, Yang D, Graff S, et al. Parallel genome-scale CRISPR screens distinguish pluripotency and self-renewal. bioRxiv. 2023;: pubmed publisher |
Waddell G, Drew E, Rupp H, Hansen S. Mechanisms controlling membrane recruitment and activation of autoinhibited SHIP1. bioRxiv. 2023;: pubmed publisher |
Nanes B, Bhatt K, Azarova E, Rajendran D, Isogai T, Dean K, et al. Keratin isoform shifts modulate motility signals during wound healing. bioRxiv. 2023;: pubmed publisher |
Kwon Y, Hui S. IL-6 is dispensable for causing cachexia in the colon carcinoma 26 model. bioRxiv. 2023;: pubmed publisher |
Zhang J, Zhu A, Mei M, Qu J, Huang Y, Shi Y, et al. Repurposing CRISPR/Cas to Discover SARS-CoV-2 Detecting and Neutralizing Aptamers. Adv Sci (Weinh). 2023;:e2300656 pubmed publisher |
Maeda Y, Isomura A, Masaki T, Kageyama R. Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21. Cell Rep. 2023;42:112520 pubmed publisher |
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen V, Januszyk K, Voorhees R. A selectivity filter in the ER membrane protein complex limits protein misinsertion at the ER. J Cell Biol. 2023;222: pubmed publisher |
Patel S, Bhatt A, Bhansali P, Setty S. Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase trafficking to lysosomes via ER stress. Traffic. 2023;24:254-269 pubmed publisher |
Hu J, Gao J, Wang C, Liu W, Hu A, Xiao X, et al. FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression. J Inflamm Res. 2023;16:2007-2020 pubmed publisher |
Jiménez Moreno N, Salomó Coll C, Murphy L, Wilkinson S. Signal-Retaining Autophagy Indicator as a Quantitative Imaging Method for ER-Phagy. Cells. 2023;12: pubmed publisher |
Li X, Shi W, Wei G, Lv J, Wang D, Xing B, et al. Galectin-1 promotes angiogenesis and chondrogenesis during antler regeneration. Cell Mol Biol Lett. 2023;28:40 pubmed publisher |
Sambri I, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo M, et al. RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun. 2023;14:2775 pubmed publisher |
McAllan L, Baranasic D, Villica xf1 a S, Brown S, Zhang W, Lehne B, et al. Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes. Nat Commun. 2023;14:2784 pubmed publisher |
Zheng Z, Ye J, Leng M, Gan C, Tang N, Li W, et al. Enhanced sensitivity of neutralizing antibody detection for different AAV serotypes using HeLa cells with overexpressed AAVR. Front Pharmacol. 2023;14:1188290 pubmed publisher |
Taye N, Singh M, Baldock C, Hubmacher D. Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating WNT signaling. Matrix Biol. 2023;120:24-42 pubmed publisher |
Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim J, et al. Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nat Commun. 2023;14:2390 pubmed publisher |
Best M, Lim Y, Ferenc N, Kim N, Min L, Wang D, et al. Extracellular Tau Oligomers Damage the Axon Initial Segment. J Alzheimers Dis. 2023;93:1425-1441 pubmed publisher |
Xu K, Liu Q, Huang W, Chu Y, Fan W, Liu J, et al. Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells. Int J Mol Sci. 2023;24: pubmed publisher |
Havranek B, Lindsey G, Higuchi Y, Itoh Y, Suzuki T, Okamoto T, et al. A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo. Commun Biol. 2023;6:513 pubmed publisher |
Kim Y, Shin S, Kwon S, Moon K, Baek S, Jo A, et al. METTL3 regulates alternative splicing of cell cycle-related genes via crosstalk between mRNA m6A modifications and splicing factors. Am J Cancer Res. 2023;13:1443-1456 pubmed |
Pilat J, Brown R, Chen Z, Berle N, Othon A, Washington M, et al. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. J Clin Invest. 2023;133: pubmed publisher |
Lin Y, Hu Q, Mazzagatti A, Valle Incl xe1 n J, Maurais E, Dahiya R, et al. Mitotic clustering of pulverized chromosomes from micronuclei. Nature. 2023;618:1041-1048 pubmed publisher |
Lyu J, Li Z, Roberts J, Qi Y, Xiong J. The short-chain fatty acid acetate coordinates with CD30 to modulate T-cell survival. Mol Biol Cell. 2023;34:br11 pubmed publisher |
Zhou J, Guruvayurappan K, Chen H, Chen A, McVicker G. Genome-wide analysis of CRISPR perturbations indicates that enhancers act multiplicatively and without epistatic-like interactions. bioRxiv. 2023;: pubmed publisher |
Quintanilla M, Patel H, Wu H, Sochacki K, Akamatsu M, Rotty J, et al. Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly. bioRxiv. 2023;: pubmed publisher |
Radoua A, Pernon B, Pernet N, Jean C, Elmallah M, Guerrache A, et al. ptARgenOM-A Flexible Vector For CRISPR/CAS9 Nonviral Delivery. Small Methods. 2023;7:e2300069 pubmed publisher |
Allchin E, Rosch J, Stoneman A, Kim H, Lippmann E. Generalized Strategy for Engineering Mammalian Cell-Compatible RNA-Based Biosensors from Random Sequence Libraries. ACS Sens. 2023;8:2079-2086 pubmed publisher |
Osipovich A, Dudek K, Trinh L, Kim L, Shrestha S, Cartailler J, et al. ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. PLoS Genet. 2023;19:e1010729 pubmed publisher |
Taha Z, Crupi M, Alluqmani N, Fareez F, Ng K, Sobh J, et al. Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus. Front Immunol. 2023;14:1181014 pubmed publisher |
Wei C, Du J, Shen Y, Wang Z, Lin Q, Chen J, et al. Anticancer effect of involucrasin A on colorectal cancer cells by modulating the Akt/MDM2/p53 pathway. Oncol Lett. 2023;25:218 pubmed publisher |
Mahr R, Jena S, Nashif S, Nelson A, Rauckhorst A, Rome F, et al. Mitochondrial citrate metabolism and efflux regulate BeWo differentiation. Sci Rep. 2023;13:7387 pubmed publisher |
Cetin R, Wegner M, Luwisch L, Saud S, Achmedov T, S xfc sser S, et al. Optimized metrics for orthogonal combinatorial CRISPR screens. Sci Rep. 2023;13:7405 pubmed publisher |
Li X, Zhang C, Bowman H, Stambough J, Stronach B, Mears S, et al. Piezo1 opposes age-associated cortical bone loss. Aging Cell. 2023;22:e13846 pubmed publisher |
Pandit M, Kil Y, Ahn J, Pokhrel R, Gu Y, Mishra S, et al. Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells. Nat Commun. 2023;14:2593 pubmed publisher |
Awadia S, Sitto M, Ram S, Ji W, Liu Y, Damani R, et al. The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity. J Biol Chem. 2023;299:104786 pubmed publisher |
Wilson B, Su Z, Kumar P, Dutta A. XRN2 suppresses aberrant entry of tRNA trailers into argonaute in humans and Arabidopsis. PLoS Genet. 2023;19:e1010755 pubmed publisher |
Sharp C, Thompson B, Nash T, Diebold O, Pinto R, Thorley L, et al. CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. PLoS Pathog. 2023;19:e1011357 pubmed publisher |
You Y, Grasso E, Alvero A, Condon J, Dimova T, Hu A, et al. Twist1-IRF9 Interaction Is Necessary for IFN-Stimulated Gene Anti-Zika Viral Infection. J Immunol. 2023;: pubmed publisher |
Zhou L, Jia X, Shang Y, Sun Y, Liu Z, Liu J, et al. PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. Mol Carcinog. 2023;62:1119-1135 pubmed publisher |
Ofek P, Yeini E, Arad G, Danilevsky A, Pozzi S, Luna C, et al. Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma. Int J Cancer. 2023;153:654-668 pubmed publisher |
Morris J, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, et al. Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens. Science. 2023;380:eadh7699 pubmed publisher |
Lu Y, Cao Q, Yu Y, Sun Y, Jiang X, Li X. Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications. BMC Genomics. 2023;24:235 pubmed publisher |
Park J, Gazzaniga F, Wu M, Luthens A, Gillis J, Zheng W, et al. Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023;617:377-385 pubmed publisher |
Wang M, Wisniewski C, Xiong C, Chhoy P, Goel H, Kumar A, et al. Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer. Sci Transl Med. 2023;15:eade5855 pubmed publisher |
Feng F, Bouma E, Hu G, Zhu Y, Yu Y, Smit J, et al. Colocalization of Chikungunya Virus with Its Receptor MXRA8 during Cell Attachment, Internalization, and Membrane Fusion. J Virol. 2023;97:e0155722 pubmed publisher |
Spear J, White K. Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition. J Cell Sci. 2023;136: pubmed publisher |
Yu C, Rao D, Wang T, Sheng J, Lv E, Zhang L, et al. Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR. J Cell Mol Med. 2023;27:1523-1538 pubmed publisher |
Bagheri M, Mohamed G, Ashick M, Saleem M, Ognjenovic N, Lu H, et al. Pharmacological Induction of mesenchymal-epithelial transition chemosensitizes breast cancer cells and prevents metastatic progression. bioRxiv. 2023;: pubmed publisher |
Bulos M, Grzelak E, Li Ma C, Chen E, Hull M, Johnson K, et al. "Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2". bioRxiv. 2023;: pubmed publisher |
Wang Y, Seibert H, Ahn L, Schaffer A, Mu T. Pharmacological chaperones restore proteostasis of epilepsy-associated GABA A receptor variants. bioRxiv. 2023;: pubmed publisher |
Wang Q, Jiang F, Zhao C, Song J, Hu M, Lv Y, et al. miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2. Heliyon. 2023;9:e15451 pubmed publisher |
Bishop T, Subramanian C, Bilotta E, Garnar Wortzel L, Ramos A, Zhang Y, et al. Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition. Nat Chem Biol. 2023;: pubmed publisher |
Li H, Lin C, Qi W, Sun Z, Xie Z, Jia W, et al. Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I. PLoS Pathog. 2023;19:e1011371 pubmed publisher |
Yu G, Kim H, Park J, Kwak H, Cheong Y, Kim D, et al. Prediction of efficiencies for diverse prime editing systems in multiple cell types. Cell. 2023;186:2256-2272.e23 pubmed publisher |
Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, et al. m6A epitranscriptomic regulation of tissue homeostasis during primate aging. Nat Aging. 2023;3:705-721 pubmed publisher |
Xiong Y, Zhang X, Zhu J, Zhang Y, Pan Y, Wu Y, et al. Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression. Cell Death Differ. 2023;30:1648-1665 pubmed publisher |
Olivas T, Wu Y, Yu S, Luan L, Choi P, Guinn E, et al. ATG9 vesicles comprise the seed membrane of mammalian autophagosomes. J Cell Biol. 2023;222: pubmed publisher |
Fu J, Pukhari M, Bador M, Sam I, Chan Y. Humoral and T Cell Immune Responses against SARS-CoV-2 after Primary and Homologous or Heterologous Booster Vaccinations and Breakthrough Infection: A Longitudinal Cohort Study in Malaysia. Viruses. 2023;15: pubmed publisher |
Elcocks H, Brazel A, McCarron K, Kaulich M, Husnjak K, Mortiboys H, et al. FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels. EMBO J. 2023;42:e112799 pubmed publisher |
Mihali x10d F, Simonetti L, Giudice G, Sander M, Lindqvist R, Peters M, et al. Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs. Nat Commun. 2023;14:2409 pubmed publisher |
Liu S, Hur Y, Cai X, Cong Q, Yang Y, Xu C, et al. A tissue injury sensing and repair pathway distinct from host pathogen defense. Cell. 2023;186:2127-2143.e22 pubmed publisher |
Qin L, Fan W, Zheng F, Chen H, Qian P, Li X. Swine IFI6 confers antiviral effects against Japanese encephalitis virus in vitro and in vivo. J Gen Virol. 2023;104: pubmed publisher |
Armendariz D, Goetsch S, Sundarrajan A, Sivakumar S, Wang Y, Xie S, et al. CHD-associated enhancers shape human cardiomyocyte lineage commitment. elife. 2023;12: pubmed publisher |
Spens A, Sutliff N, Bennett S, Campbell A, Tapscott S. Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. elife. 2023;12: pubmed publisher |
Iyengar P, Gandhi A, Granados J, Guo T, Gupta A, Yu J, et al. Tumor loss-of-function mutations in STK11/LKB1 induce cachexia. JCI Insight. 2023;8: pubmed publisher |
Rogers B, Anderson A, Lauzon S, Davis M, Hauser R, Roberts S, et al. MAPT expression is mediated by long-range interactions with cis -regulatory elements. bioRxiv. 2023;: pubmed publisher |
Yoon D, Choi Y, Lee K, Ko E, Kim E, Park K, et al. Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. J Biomed Sci. 2023;30:26 pubmed publisher |
Segal E, Nissenbaum J, Peretz M, Golan Lev T, Cashman R, Philip H, et al. Genome-wide screen for anticancer drug resistance in haploid human embryonic stem cells. Cell Prolif. 2023;56:e13475 pubmed publisher |
Gupta A, Li Y, Chen S, Papas B, Martin N, Morgan M. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Commun Biol. 2023;6:438 pubmed publisher |
Fan W, Jurado Arjona J, Alanis Lobato G, P xe9 ron S, Berger C, Andrade Navarro M, et al. The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. EMBO J. 2023;42:e110384 pubmed publisher |
Fu L, Wang X, Yang Y, Chen M, Kuerban A, Liu H, et al. Septin11 promotes hepatocellular carcinoma cell motility by activating RhoA to regulate cytoskeleton and cell adhesion. Cell Death Dis. 2023;14:280 pubmed publisher |
Li M, Yang L, Chan A, Pokharel S, Liu Q, Mattson N, et al. Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis. Adv Sci (Weinh). 2023;10:e2206584 pubmed publisher |
Pawlak J, Hsu J, Xia H, Han P, Suh H, Grove T, et al. CMPK2 restricts Zika virus replication by inhibiting viral translation. PLoS Pathog. 2023;19:e1011286 pubmed publisher |
Balaban A, Nguyen L, Paraj xf3 n E, Robinson D. Nonmuscle myosin IIB is a driver of cellular reprogramming. Mol Biol Cell. 2023;34:ar71 pubmed publisher |
McCollum C, Didychuk A, Liu D, Murray Nerger L, Cristea I, Glaunsinger B. The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection. PLoS Pathog. 2023;19:e1011163 pubmed publisher |
Hayes B, Wang M, Zhu H, Phan S, Andrechak J, Chang A, et al. Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response. bioRxiv. 2023;: pubmed publisher |
Bach S, Bauman A, Hosein D, Tuscher J, Ianov L, Greathouse K, et al. Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons. bioRxiv. 2023;: pubmed publisher |
Jo D, Kaczmarek S, Shin O, Wang L, Cowan J, McComb S, et al. Simultaneous engineering of natural killer cells for CAR transgenesis and CRISPR-Cas9 knockout using retroviral particles. Mol Ther Methods Clin Dev. 2023;29:173-184 pubmed publisher |
Basu A, Champagne R, Patel N, Nicholson E, Weiss R. TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth. J Biol Chem. 2023;299:104713 pubmed publisher |
Chandra K, Swathi M, Keerthana B, Gopan S, Ghantasala J, Joshi M, et al. PHLPP1 regulates PINK1-parkin signalling and life span. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166718 pubmed publisher |
Murakami Nishimagi Y, Sugimoto K, Kobayashi M, Tachibana K, Kojima M, Okano M, et al. Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β. Breast Cancer Res. 2023;25:41 pubmed publisher |
Haluck Kangas A, Fink M, Bartom E, Peter M. CD95/Fas ligand mRNA is toxic to cells through more than one mechanism. Mol Biomed. 2023;4:11 pubmed publisher |
Kurden Pekmezci A, Cakiroglu E, Eris S, Mazi F, Coskun Deniz O, Dalgic E, et al. MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth. Life Sci. 2023;323:121690 pubmed publisher |
Tomofuji K, Kondo J, Onuma K, Coppo R, Horie H, Oyama K, et al. Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Hepatol Commun. 2023;7: pubmed publisher |
M xf6 ller A, Jauch Speer S, Gandhi S, Vogl T, Roth J, Fehler O. The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9. Front Immunol. 2023;14:1110185 pubmed publisher |
Wang L, Paudel B, McKnight R, Janes K. Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state. Nat Commun. 2023;14:2110 pubmed publisher |
Pourzia A, Olson M, Bailey S, Boroughs A, Aryal A, Ryan J, et al. Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells. Cell Death Dis. 2023;14:267 pubmed publisher |
Walker C, Greathouse K, Tuscher J, Dammer E, Weber A, Liu E, et al. Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length. J Neurosci. 2023;43:3764-3785 pubmed publisher |
Stewart C, Bo Y, Fu K, Chan M, Kozak R, Apperley K, et al. Sphingosine Kinases Promote Ebola Virus Infection and Can Be Targeted to Inhibit Filoviruses, Coronaviruses, and Arenaviruses Using Late Endocytic Trafficking to Enter Cells. ACS Infect Dis. 2023;9:1064-1077 pubmed publisher |
Kurhade C, Kang S, Biering S, Hwang S, Randall G. CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. MBio. 2023;14:e0017223 pubmed publisher |
Abuhamad A, Mohamad Zamberi N, Vanharanta S, Mohd Yusuf S, Mohtar M, Syafruddin S. Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma. Int J Mol Sci. 2023;24: pubmed publisher |
Galappaththi S, Katz B, Howze P, Hoover G, Grelet S. A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation. Cancers (Basel). 2023;15: pubmed publisher |
Shitaoka K, Higashiura A, Kawano Y, Yamamoto A, Mizoguchi Y, Hashiguchi T, et al. Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants. Commun Biol. 2023;6:395 pubmed publisher |
Luo Y, Liu S, Xue J, Yang Y, Zhao J, Sun Y, et al. High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2. Cell Discov. 2023;9:40 pubmed publisher |
Truong M, Can xe9 Gasull P, De Vries S, Nijenhuis W, Wardenaar R, Kapitein L, et al. A kinesin-based approach for inducing chromosome-specific mis-segregation in human cells. EMBO J. 2023;42:e111559 pubmed publisher |
Zhang Z, Yu T, Li H, Du L, Jin Z, Peng X, et al. Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis. Microbiol Spectr. 2023;11:e0420622 pubmed publisher |
Tsuji T, Zhang Y, Tseng Y. Generation of Brown Fat-Specific Knockout Mice Using a Combined Cre-LoxP, CRISPR-Cas9, and Adeno-Associated Virus Single-Guide RNA System. J Vis Exp. 2023;: pubmed publisher |
Li J, Wan F, Zhang J, Zheng S, Yang Y, Hong Z, et al. Targeting SMYD2 inhibits prostate cancer cell growth by regulating c-Myc signaling. Mol Carcinog. 2023;62:940-950 pubmed publisher |
Zhao X, Wu X, Wang H, Lai S, Wang J. Targeted therapy for cisplatin-resistant lung cancer via aptamer-guided nano-zinc carriers containing USP14 siRNA. MedComm (2020). 2023;4:e237 pubmed publisher |
Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, et al. Asparagine starvation suppresses histone demethylation through iron depletion. iScience. 2023;26:106425 pubmed publisher |
Kim T, Koo S, Riessland M, Cho H, Chaudhry F, Kolisnyk B, et al. TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron. bioRxiv. 2023;: pubmed publisher |
Eren S, Tastan C, Karadeniz K, Turan R, Çakırsoy D, Kançağı D, et al. Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease. Curr Gene Ther. 2023;23:304-315 pubmed publisher |
Kwon P, Xu S, Oh H, Kwon S, Rodrigues A, Feroz M, et al. Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions. Commun Biol. 2023;6:387 pubmed publisher |
Usluer S, Hallast P, Crepaldi L, Zhou Y, Urgo K, Dincer C, et al. Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells. Stem Cell Reports. 2023;18:1061-1074 pubmed publisher |
Yamaguchi S, Xie Q, Ito F, Terao K, Kato Y, Kuroiwa M, et al. Carbon nanotube recognition by human Siglec-14 provokes inflammation. Nat Nanotechnol. 2023;18:628-636 pubmed publisher |
Xie H, Yang E, Wang C, Peng C, Ji L. Targeting HDAC11 activity by FT895 restricts EV71 replication. Virus Res. 2023;330:199108 pubmed publisher |
Hsu W, Ma Y, Chen Y, Liu Y, Cheng K, Lee E. Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN. PLoS ONE. 2023;18:e0283908 pubmed publisher |
Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, et al. A stress-induced cilium-to-PML-NB route drives senescence initiation. Nat Commun. 2023;14:1840 pubmed publisher |
Descovich C, Lough K, Jena A, Wu J, Yom J, Spitzer D, et al. AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis. elife. 2023;12: pubmed publisher |
Gao J, Hu J, Yu F, Wang C, Sheng D, Liu W, et al. Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling. BMC Cancer. 2023;23:306 pubmed publisher |
Zheng Z, Wu M, Li H, Xu W, Yang M, Pan K, et al. Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis. BMC Med. 2023;21:132 pubmed publisher |
Frost J, Amante S, Okae H, Jones E, Ashley B, Lewis R, et al. Regulation of human trophoblast gene expression by endogenous retroviruses. Nat Struct Mol Biol. 2023;30:527-538 pubmed publisher |
Ren W, Zhang Y, Rao J, Wang Z, Lan J, Liu K, et al. Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant. MBio. 2023;14:e0041623 pubmed publisher |
Kim Y, Lee M, Lee Y, Jing J, Sanders J, Botten G, et al. Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions. Sci Adv. 2023;9:eadg1123 pubmed publisher |
Barua D, Sultana A, Islam M, Cox F, Gupta A, Gupta S. RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity. BMC Cancer. 2023;23:288 pubmed publisher |
Nadler M, Chang W, Ozkaynak E, Huo Y, Nong Y, Boillot M, et al. Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation. Commun Biol. 2023;6:347 pubmed publisher |
Moyer A, Fernandez F, Li Y, Klinedinst D, Florea L, Kazuki Y, et al. Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome. Dis Model Mech. 2023;16: pubmed publisher |
Hu C, Wang A, Fan D, Worth M, Chen Z, Huang J, et al. Cancer-derived mutation in the OGA stalk domain promotes cell malignancy through dysregulating PDLIM7 and p53. Res Sq. 2023;: pubmed publisher |
Bartosch A, Youth E, Hansen S, Kaufman M, Xiao H, Koo S, et al. ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease. bioRxiv. 2023;: pubmed publisher |
Baniulyte G, Durham S, Merchant L, Sammons M. Shared gene targets of the ATF4 and p53 transcriptional networks. bioRxiv. 2023;: pubmed publisher |
Virga D, Hamilton S, Osei B, Morgan A, Zamponi E, Park N, et al. Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons. bioRxiv. 2023;: pubmed publisher |
Conti B, Ruiz P, Broton C, Blobel N, Kottemann M, Sridhar S, et al. RTF2 controls replication repriming and ribonucleotide excision at the replisome. bioRxiv. 2023;: pubmed publisher |
Delgado J, Wallace Shepard L, Lamson S, Liu S, Shoemaker C. The ER membrane protein complex governs lysosomal turnover of a mitochondrial tail-anchored protein, BNIP3, to restrict mitophagy. bioRxiv. 2023;: pubmed publisher |
Zhang W, Lu C, Nakamoto M, Tsai C, Roy A, Lee C, et al. Curved adhesions mediate cell attachment to soft matrix fibres in 3D. bioRxiv. 2023;: pubmed publisher |
Zhang L, He W, Fu R, Xu H. Guide-specific loss of efficiency and off-target reduction with Cas9 variants. bioRxiv. 2023;: pubmed publisher |
Bhat A, Mohapatra B, Luan H, Mushtaq I, Chakraborty S, Dutta S, et al. Role of GD2 and its biosynthetic enzyme GD3 synthase in prostate cancer tumorigenesis. bioRxiv. 2023;: pubmed publisher |
Takaku M, Saotome M, Poduval D, Grimm S, Nagornyuk A, Gunarathna S, et al. Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. Res Sq. 2023;: pubmed publisher |
Tsuchida C, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, et al. Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. bioRxiv. 2023;: pubmed publisher |
Zhao Y, Teng H, Deng Y, Sheldon M, Martínez C, Zhang J, et al. Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis. Res Sq. 2023;: pubmed publisher |
Twentyman J, Khalifeh A, Felton A, Emerman M, OhAinle M. Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor. bioRxiv. 2023;: pubmed publisher |
Alcantara M, Higuchi Y, Kirita Y, Matoba S, Hoshino A. Deep Mutational Scanning to Predict Escape from Bebtelovimab in SARS-CoV-2 Omicron Subvariants. Vaccines (Basel). 2023;11: pubmed publisher |
Tuano N, Beesley J, Manning M, Shi W, Perlaza Jiménez L, Malaver Ortega L, et al. CRISPR screens identify gene targets at breast cancer risk loci. Genome Biol. 2023;24:59 pubmed publisher |
De Rosa P, Severi F, Zadran S, Russo M, Aloisi S, Rigamonti A, et al. MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells. Int J Mol Sci. 2023;24: pubmed publisher |
Kroll M, Schloer S, Candan P, Korthals N, Wenzel C, Ihle H, et al. Importance of ACE2 for SARS-CoV-2 Infection of Kidney Cells. Biomolecules. 2023;13: pubmed publisher |
Thomas S, Dienger Stambaugh K, Jordan M, Wang Y, Hammonds J, Spearman P, et al. Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species. Bioengineering (Basel). 2023;10: pubmed publisher |
Tomihari A, Kiyota M, Matsuura A, Itakura E. Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins. Sci Rep. 2023;13:4680 pubmed publisher |
Yashar W, Curtiss B, Coleman D, VanCampen J, Kong G, Macaraeg J, et al. Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia. Mol Cancer Res. 2023;21:631-647 pubmed publisher |
Cao M, Zou X, Li C, Lin Z, Wang N, Zou Z, et al. An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis. Nat Commun. 2023;14:1687 pubmed publisher |
Kim J, Hwang Y, Kim S, Chang Y, Kim Y, Kwon Y, et al. Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson-Gilford progeria syndrome in mice. Aging Cell. 2023;22:e13825 pubmed publisher |
Wang Y, Kelso A, Karamafrooz A, Chen Y, Chen W, Cheng C, et al. Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination. Cell Rep. 2023;42:112296 pubmed publisher |
Hu Z, Liu Y, Tang J, Luo R, Qin J, Mo Z, et al. LncRNA HHIP-AS1 suppresses lung squamous cell carcinoma by stabilizing HHIP mRNA. Life Sci. 2023;321:121578 pubmed publisher |
Jbara A, Lin K, Stossel C, Siegfried Z, Shqerat H, Amar Schwartz A, et al. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature. 2023;617:147-153 pubmed publisher |
Martin E, Rodriguez Y Baena A, Reggiardo R, Worthington A, Mattingly C, Poscablo D, et al. Dynamics of Chromatin Accessibility During Hematopoietic Stem Cell Differentiation Into Progressively Lineage-Committed Progeny. Stem Cells. 2023;41:520-539 pubmed publisher |
Agarwal V, Inoue F, Schubach M, Martin B, Dash P, Zhang Z, et al. Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types. bioRxiv. 2023;: pubmed publisher |
Zhao P, Sun L, Zhao C. TCF1/LEF1 triggers Wnt-dependent chemokine/cytokine-induced inflammation and cadherin pathways to drive T-ALL cell migration. Biochem Biophys Rep. 2023;34:101457 pubmed publisher |
Pati xf1 o Mercau J, Bali xf1 as Gavira C, Andrades Á, Benitez Cantos M, Rot A, Rodriguez M, et al. BCL7A is silenced by hypermethylation to promote acute myeloid leukemia. Biomark Res. 2023;11:32 pubmed publisher |
Pan C, Li R, Shui L, Xiao Z, Wang Y, Zhu J, et al. A new method to synthesize multiple gRNA libraries and functional mapping of mammalian H3K4me3 regions. Nucleic Acids Res. 2023;51:e50 pubmed publisher |
Tasca F, Brescia M, Liu J, Janssen J, Mamchaoui K, Gon xe7 alves M. High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells. Mol Ther Nucleic Acids. 2023;31:746-762 pubmed publisher |
Li W, Liu S, Wang C, Cui L, Zhao X, Liu W, et al. DNMT3A low-expression is correlated to poor prognosis in childhood B-ALL and confers resistance to daunorubicin on leukemic cells. BMC Cancer. 2023;23:255 pubmed publisher |
Fan Z, Ardicoglu R, Batavia A, Rust R, von Ziegler L, Waag R, et al. The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions. Angiogenesis. 2023;26:385-407 pubmed publisher |
Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, et al. Single-cell transcriptomic atlas of mouse cochlear aging. Protein Cell. 2023;14:180-201 pubmed publisher |
Tian R, Yang J, Wang X, Liu S, Dong R, Wang Z, et al. Honokiol acts as an AMPK complex agonist therapeutic in non-alcoholic fatty liver disease and metabolic syndrome. Chin Med. 2023;18:30 pubmed publisher |
Li K, Figarella K, Su X, Kovalchuk Y, Gorzolka J, Neher J, et al. Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb. Cell Mol Life Sci. 2023;80:98 pubmed publisher |
Eichner L, Curtis S, Brun S, McGuire C, Gushterova I, Baumgart J, et al. HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer. Sci Adv. 2023;9:eadd3243 pubmed publisher |
Gilhaus K, Cepok C, Kamm D, Surmann B, Nedvetsky P, Emich J, et al. Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins. J Am Soc Nephrol. 2023;34:1039-1055 pubmed publisher |
Zhang Q, Li J, Chen Z, Jiang K, Yang K, Huang F, et al. VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma. Cell Oncol (Dordr). 2023;46:1001-1014 pubmed publisher |
He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, et al. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. Protein Cell. 2023;14:202-216 pubmed publisher |
Patel P, Algouneh A, Krishnan R, Reynolds J, Nixon K, Hao J, et al. Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. Nucleic Acids Res. 2023;51:4341-4362 pubmed publisher |
Tao A, Lacroix A, Shoyer T, Venkatraman V, Xu K, Feiger B, et al. Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions. Dev Cell. 2023;58:522-534.e7 pubmed publisher |
McCann J, FLEENOR D, Chen J, Lai C, Bass T, Kastan M. Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway. Radiat Res. 2023;199:406-421 pubmed publisher |
Zhang X, Du Q, Chen G, Jiang Y, Huang K, Li L, et al. Guanylate-binding protein 1 inhibits nuclear delivery of pseudorabies virus by disrupting structure of actin filaments. Vet Res. 2023;54:21 pubmed publisher |
Tang X, Xue D, Zhang T, Nilsson Payant B, Carrau L, Duan X, et al. A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nat Cell Biol. 2023;25:381-389 pubmed publisher |
Uno S, Harkiss A, Chowdhury R, Caldwell S, Prime T, James A, et al. Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs. Chembiochem. 2023;24:e202200774 pubmed publisher |
Xu H, Li Z, Kuo C, G xf6 tz K, Look T, de Toledo M, et al. A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation. elife. 2023;12: pubmed publisher |
Reddy A, Herschl M, Kolli S, Lu A, Geng X, Kumar A, et al. Pretraining strategies for effective promoter-driven gene expression prediction. bioRxiv. 2023;: pubmed publisher |
Illangeswaran R, Jebanesan D, Sivakumar K, Vidhyadharan R, Rajamani B, Janet N, et al. Chemotherapeutic drugs elicit stemness and metabolic alteration to mediate acquired drug-resistant phenotype in acute myeloid leukemia cell lines. Leuk Res. 2023;128:107054 pubmed publisher |
P xf6 hlking C, Beier S, Formanski J, Friese M, Schreiber M, Schwalbe B. Isolation of Cells from Glioblastoma Multiforme Grade 4 Tumors for Infection with Zika Virus prME and ME Pseudotyped HIV-1. Int J Mol Sci. 2023;24: pubmed publisher |
Yang Y, Zhang M, Zhang Y, Liu K, Lu C. 5-Fluorouracil Suppresses Colon Tumor through Activating the p53-Fas Pathway to Sensitize Myeloid-Derived Suppressor Cells to FasL+ Cytotoxic T Lymphocyte Cytotoxicity. Cancers (Basel). 2023;15: pubmed publisher |
Nair H, Jurkiewicz A, Graczyk D. Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFα. Cancers (Basel). 2023;15: pubmed publisher |
Ren Y, Song Z, Rieser J, Ackermann J, Koch I, Lv X, et al. USP15 Represses Hepatocellular Carcinoma Progression by Regulation of Pathways of Cell Proliferation and Cell Migration: A System Biology Analysis. Cancers (Basel). 2023;15: pubmed publisher |
Huang Z, Rui X, Yi C, Chen Y, Chen R, Liang Y, et al. Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling. J Exp Clin Cancer Res. 2023;42:60 pubmed publisher |
Szwarc M, Guarnieri A, Joshi M, Duc H, Laird M, Pandey A, et al. FAM193A is a positive regulator of p53 activity. Cell Rep. 2023;42:112230 pubmed publisher |
Sobajima T, Kowalczyk K, Skylakakis S, Hayward D, Fulcher L, Neary C, et al. PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. J Cell Biol. 2023;222: pubmed publisher |
Qin Z, Zhang W, Liu S, Wang Y, Peng X, Jia L. PVT1 inhibition stimulates anti-tumor immunity, prevents metastasis, and depletes cancer stem cells in squamous cell carcinoma. Cell Death Dis. 2023;14:187 pubmed publisher |
Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude K, Wang N, et al. Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc Natl Acad Sci U S A. 2023;120:e2218238120 pubmed publisher |
Zecchini V, Paupe V, Herranz Montoya I, Janssen J, Wortel I, Morris J, et al. Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature. 2023;615:499-506 pubmed publisher |
Ghantous L, Volman Y, Hefez R, Wald O, STERN E, Friehmann T, et al. The DNA damage response pathway regulates the expression of the immune checkpoint CD47. Commun Biol. 2023;6:245 pubmed publisher |
Yende A, Williams E, Pletcher A, Helfand A, Ibeawuchi H, North T, et al. TRIM28 promotes luminal cell plasticity in a mouse model of prostate cancer. Oncogene. 2023;42:1347-1359 pubmed publisher |
Huang S, Li J, Wu S, Zheng Z, Wang C, Li H, et al. C4orf19 inhibits colorectal cancer cell proliferation by competitively binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6 axis. Oncogene. 2023;42:1333-1346 pubmed publisher |
Park J, Cui G, Lee H, Jeong H, Kwak J, Lee J, et al. CRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularization. Sci Rep. 2023;13:3715 pubmed publisher |
Wang Z, Liang Q, Qian X, Hu B, Zheng Z, Wang J, et al. An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Nat Commun. 2023;14:1208 pubmed publisher |
Phan Q, Solis N, Cravener M, Swidergall M, Lin J, Huang M, et al. Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. bioRxiv. 2023;: pubmed publisher |
Francis C, Bell M, Skripnichuk M, Kushner E. Arf6 Regulates Endocytosis and Angiogenesis by Promoting Filamentous Actin Assembly. bioRxiv. 2023;: pubmed publisher |
Yu M, Hu X, Pan Z, Du C, Jiang J, Zheng W, et al. Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Nucleic Acids Res. 2023;51:4745-4759 pubmed publisher |
Tylawsky D, Kiguchi H, Vaynshteyn J, Gerwin J, Shah J, Islam T, et al. P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis. Nat Mater. 2023;22:391-399 pubmed publisher |
Xie H, Kang Y, Liu J, Huang M, Dai Z, Shi J, et al. Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biol. 2023;21:e3002008 pubmed publisher |
Yamamoto Y, Shimada S, Akiyama Y, Tsukihara S, Sugimoto R, Kabashima A, et al. RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. J Gastroenterol. 2023;58:540-553 pubmed publisher |
Norris M, Mendell J. Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein. Genes Dev. 2023;37:191-203 pubmed publisher |
Iwasaki Y, Aksu C, Reyes M, Ay B, He Q, Bastepe M. The long-range interaction between two GNAS imprinting control regions delineates pseudohypoparathyroidism type 1B pathogenesis. J Clin Invest. 2023;133: pubmed publisher |
Pastor S, Wicinski J, Charafe Jauffret E, Verhoeyen E, Guittard G, Ginestier C. Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors. STAR Protoc. 2023;4:102055 pubmed publisher |
Simeoni F, Loukas I, Wilson T, Scaffidi P. CRISPR-based large-scale modeling of loss-of-function mutations to investigate mechanisms of stress resistance in cancer. STAR Protoc. 2023;4:102097 pubmed publisher |
An H, Tian X, Huang Y, Zhang J. Identification of the mouse Kupffer cell receptors recognizing pneumococcal capsules by affinity screening. STAR Protoc. 2023;4:102065 pubmed publisher |
Ran X, Lu Q, Li Y, Pu X, Guo Y, Yuan M, et al. Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway. Heliyon. 2023;9:e13691 pubmed publisher |
Fricke T, Schlagowski S, Liu S, Yang X, Fiebig U, Kaul A, et al. Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins. Viruses. 2023;15: pubmed publisher |
Gulden G, Sert B, Teymur T, Ay Y, Tiryaki N, Mishra A, et al. CAR-T Cells with Phytohemagglutinin (PHA) Provide Anti-Cancer Capacity with Better Proliferation, Rejuvenated Effector Memory, and Reduced Exhausted T Cell Frequencies. Vaccines (Basel). 2023;11: pubmed publisher |
Sui X, Chen C, Zhou X, Wen X, Shi C, Chen G, et al. Integrative analysis of bulk and single-cell gene expression profiles to identify tumor-associated macrophage-derived CCL18 as a therapeutic target of esophageal squamous cell carcinoma. J Exp Clin Cancer Res. 2023;42:51 pubmed publisher |
G xf6 bel T, Goebel B, Hyprath M, Lamminger I, Weisser H, Angioni C, et al. Three-dimensional growth reveals fine-tuning of 5-lipoxygenase by proliferative pathways in cancer. Life Sci Alliance. 2023;6: pubmed publisher |
Yan C, Meng Y, Yang J, Chen J, Jiang W. Translational landscape in human early neural fate determination. Development. 2023;150: pubmed publisher |
Shlyakhtina Y, Bloechl B, Portal M. BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity. Nat Commun. 2023;14:1085 pubmed publisher |
Ilter D, Drápela S, Schild T, Ward N, Adhikari E, Low V, et al. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023;61:102627 pubmed publisher |
Valiullina A, Zmievskaya E, Ganeeva I, Zhuravleva M, Garanina E, Rizvanov A, et al. Evaluation of CAR-T Cells' Cytotoxicity against Modified Solid Tumor Cell Lines. Biomedicines. 2023;11: pubmed publisher |
Parker S, Ly K, Grant A, Sweetland J, Wang A, Parker J, et al. EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons. J Cell Biol. 2023;222: pubmed publisher |
Kroken A, Klein K, Mitchell P, Nieto V, Jedel E, Evans D, et al. Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. bioRxiv. 2023;: pubmed publisher |
Cicardi M, Hallgren J, Mawrie D, Krishnamurthy K, Markandaiah S, Nelson A, et al. C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress. bioRxiv. 2023;: pubmed publisher |
Rosenberger G, Li W, Turunen M, He J, Subramaniam P, Pampou S, et al. Network-based elucidation of colon cancer drug resistance by phosphoproteomic time-series analysis. bioRxiv. 2023;: pubmed publisher |
Teryek M, Jadhav P, Bento R, Parekkadan B. 3D Microcapsules for Human Bone Marrow Derived Mesenchymal Stem Cell Biomanufacturing in a Vertical-Wheel Bioreactor. bioRxiv. 2023;: pubmed publisher |
Kim D, Kim G, Yu R, Lee J, Kim S, Qiu K, et al. Lymphocyte activation gene 3 (Lag3) supports Foxp3 + Treg cell function by restraining c-Myc-dependent aerobic glycolysis. bioRxiv. 2023;: pubmed publisher |
Liu P, Chen Y, Li X, Hsueh P, Tzeng S, Chen H, et al. CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions. Nat Immunol. 2023;24:452-462 pubmed publisher |
He L, Shi H, Zhang G, Peng Y, Ghosh A, Zhang M, et al. A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition. J Neurosci. 2023;43:2305-2325 pubmed publisher |
Wang S, Chen X, Crisman L, Dou X, Winborn C, Wan C, et al. Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module. Sci Adv. 2023;9:eade2540 pubmed publisher |
Montemagno C, Durivault J, Gastaldi C, Dufies M, Vial V, He X, et al. A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma. Mol Oncol. 2023;17:1379-1401 pubmed publisher |
Lee B, Hoyle C, Wellens R, Green J, Martín Sánchez F, Williams D, et al. Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome. Sci Signal. 2023;16:eabm7134 pubmed publisher |
Bi J, Jin X, Zheng C, Huang C, Zhong C, Zheng X, et al. Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells. Adv Sci (Weinh). 2023;10:e2207499 pubmed publisher |
Ahmed I, Yang S, Ogden S, Zhang W, Li Y, Sharrocks A. eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways. elife. 2023;12: pubmed publisher |
Buyukcelebi K, Chen X, Abdula F, Duval A, Ozturk H, Seker Polat F, et al. Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Res Sq. 2023;: pubmed publisher |
Mohr M, Li S, Trouten A, Stairley R, Roddy P, Liu C, et al. Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. bioRxiv. 2023;: pubmed publisher |
Smith F, Kosman D. Frataxin-deficient human brain microvascular endothelial cells lose polymerized actin and are paracellularly permeable -implications for blood-brain barrier integrity in Friedreich's Ataxia. bioRxiv. 2023;: pubmed publisher |
Itell H, Humes D, Overbaugh J. Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4 + T cells. bioRxiv. 2023;: pubmed publisher |
King C, Liu Y, Amato K, Schaack G, Hu T, Smith J, et al. Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection. bioRxiv. 2023;: pubmed publisher |
Koeppel J, Weller J, Peets E, Pallaseni A, Kuzmin I, Raudvere U, et al. Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants. Nat Biotechnol. 2023;: pubmed publisher |
Nandi I, Smith H, Sanguin Gendreau V, Ji L, Pacis A, Papavasiliou V, et al. Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. J Clin Invest. 2023;133: pubmed publisher |
Laspata N, Kaur P, Mersaoui S, Muoio D, Liu Z, Bannister M, et al. PARP1 associates with R-loops to promote their resolution and genome stability. Nucleic Acids Res. 2023;51:2215-2237 pubmed publisher |
Zheng X, Wang M, Liu S, Chen H, Li Y, Yuan F, et al. A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury. Cell Death Dis. 2023;14:126 pubmed publisher |
Aw W, Cho C, Wang H, Cooper A, Doherty E, Rocco D, et al. Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Sci Adv. 2023;9:eade8939 pubmed publisher |
Jin D, Chen X, Liu Y, Williams C, Pedersen L, Stafford D, et al. A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Nat Commun. 2023;14:828 pubmed publisher |
Dhital B, Santasusagna S, Kirthika P, Xu M, Li P, Carceles Cordon M, et al. Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer. Cell Rep Med. 2023;4:100937 pubmed publisher |
Puccini J, Wei J, Tong L, Bar Sagi D. Cytoskeletal association of ATP citrate lyase controls the mechanodynamics of macropinocytosis. Proc Natl Acad Sci U S A. 2023;120:e2213272120 pubmed publisher |
Huang R, Yamamoto T, Nakata E, Ozaki T, Kurozumi K, Wei F, et al. CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex. Adv Sci (Weinh). 2023;10:e2206542 pubmed publisher |
Praharaj P, Patra S, Mishra S, Mukhopadhyay S, Klionsky D, Patil S, et al. CLU (clusterin) promotes mitophagic degradation of MSX2 through an AKT-DNM1L/Drp1 axis to maintain SOX2-mediated stemness in oral cancer stem cells. Autophagy. 2023;19:2196-2216 pubmed publisher |
Saad M, Grimaldo Garcia S, Sweeney A, Mallidi S, Hasan T. A Dual Function Antibody Conjugate Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids. bioRxiv. 2023;: pubmed publisher |
Hu M, Yang B, Jensen T, Radda J, Cheng Y, Jin S, et al. High-content image-based CRISPR screening reveals regulators of 3D genome architectures. bioRxiv. 2023;: pubmed publisher |
Collignon E, Cho B, Fothergill Robinson J, Furlan G, Ross R, Limbach P, et al. m 6 A RNA methylation orchestrates transcriptional dormancy during developmental pausing. bioRxiv. 2023;: pubmed publisher |
Wang K, Yu Y, Wang W, Jiang Y, Li Y, Jiang X, et al. Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer. Oncogene. 2023;42:1072-1087 pubmed publisher |
Wang S, Chen Y, Wu H, Li X, Xiao H, Pan Q, et al. Role of Transcription Factor EB in Mitochondrial Dysfunction of Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2023;24: pubmed publisher |
Roy G, Yang T, Liu S, Luo Y, Liu Y, Zhong Q. Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma. Int J Mol Sci. 2023;24: pubmed publisher |
Charv xe1 tov xe1 S, Motais B, Czapla J, Cicho x144 T, Smolarczyk R, Walek Z, et al. Novel Local "Off-the-Shelf" Immunotherapy for the Treatment of Myeloma Bone Disease. Cells. 2023;12: pubmed publisher |
Muselli F, Mourgues L, Rochet N, Nebout M, Guerci A, Verhoeyen E, et al. Repurposing the Bis-Biguanide Alexidine in Combination with Tyrosine Kinase Inhibitors to Eliminate Leukemic Stem/Progenitor Cells in Chronic Myeloid Leukemia. Cancers (Basel). 2023;15: pubmed publisher |
Yan Y, Gauthier M, Malik A, Fotiadou I, Ostrovski M, Dervovic D, et al. The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma. Cancers (Basel). 2023;15: pubmed publisher |
Jagoda E, Marnetto D, Senevirathne G, Gonzalez V, Baid K, Montinaro F, et al. Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals. elife. 2023;12: pubmed publisher |
Ozkan N, Yigit B, Degirmenci B, Qureshi M, Yapici G, Kamac x131 oglu A, et al. Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis. J Cell Sci. 2023;136: pubmed publisher |
Papadaki G, Ani O, Florio T, Young M, Danon J, Sun Y, et al. Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules. Front Immunol. 2023;14:1116906 pubmed publisher |
Sapozhnikov D, Szyf M. The PROTECTOR strategy employs dCas orthologs to sterically shield off-target sites from CRISPR/Cas activity. Sci Rep. 2023;13:2280 pubmed publisher |
Jeong H, Hong E, Ahn J, Cho J, Jeong J, Kim C, et al. ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions. Exp Mol Med. 2023;55:401-412 pubmed publisher |
Han D, Liu G, Oh Y, Oh S, Yang S, Mandjikian L, et al. ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells. Nat Commun. 2023;14:632 pubmed publisher |
Loo L, Waller M, Moreno C, Cole A, Stella A, Pop O, et al. Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. PLoS Biol. 2023;21:e3001967 pubmed publisher |
Ho W, Mondal I, Xu B, Das O, Sun R, Chiou P, et al. PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages. J Clin Invest. 2023;133: pubmed publisher |
Zhu G, Badonyi M, Franklin L, Seabra L, Rice G, Anne Boland Auge -, et al. Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2. J Clin Immunol. 2023;43:808-818 pubmed publisher |
Lari A, Glaunsinger B. Murine Gammaherpesvirus 68 ORF45 Stimulates B2 Retrotransposon and Pre-tRNA Activation in a Manner Dependent on Mitogen-Activated Protein Kinase (MAPK) Signaling. Microbiol Spectr. 2023;11:e0017223 pubmed publisher |
Zou M, Mangum K, Magin J, Cao H, Yarboro M, Shelton E, et al. Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. JCI Insight. 2023;8: pubmed publisher |
White M, Jacobs K, Singh T, Kutys M. Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. bioRxiv. 2023;: pubmed publisher |
Aldea D, Kokalari B, Atsuta Y, Dingwall H, Zheng Y, Nace A, et al. Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development. PLoS Genet. 2023;19:e1010614 pubmed publisher |
Montoya V, Ready T, Felton A, Fine S, OhAinle M, Emerman M. A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains. MBio. 2023;14:e0000923 pubmed publisher |
Rom xe1 n Fern xe1 ndez A, Mansour M, Kugeratski F, Anand J, Sandilands E, Galbraith L, et al. Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Sci Adv. 2023;9:eabq1858 pubmed publisher |
Ishii S, Chino H, Ode K, Kurikawa Y, Ueda H, Matsuura A, et al. CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy. Mol Biol Cell. 2023;34:ar29 pubmed publisher |
Ganesan S, Alvarez N, Steiner S, Fowler K, Corona A, Roy C. Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection. MBio. 2023;14:e0354522 pubmed publisher |
Rosspopoff O, Cazottes E, Huret C, Loda A, Collier A, Casanova M, et al. Species-specific regulation of XIST by the JPX/FTX orthologs. Nucleic Acids Res. 2023;51:2177-2194 pubmed publisher |
Essletzbichler P, Sedlyarov V, Frommelt F, Soulat D, Heinz L, Stefanovic A, et al. A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery. Life Sci Alliance. 2023;6: pubmed publisher |
Boila L, Ghosh S, Bandyopadhyay S, Jin L, Murison A, Zeng A, et al. KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Leukemia. 2023;: pubmed publisher |
Frost T, Gartin A, Liu M, Cheng J, Dharaneeswaran H, Keskin D, et al. YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma. J Clin Invest. 2023;133: pubmed publisher |
Stein B, Ferrarone J, Gardner E, Chang J, Wu D, Hollstein P, et al. LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer Discov. 2023;13:1002-1025 pubmed publisher |
Lin C, Traets J, Vredevoogd D, Visser N, Peeper D. TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling. EMBO J. 2023;42:e111614 pubmed publisher |
Campbell S, Chirasani V, Khan M, Malavade J, DOKHOLYAN N, Hoffman B. Elucidation of the Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Res Sq. 2023;: pubmed publisher |
Shoyer T, Gates E, Cabe J, Conway D, Hoffman B. Coupling During Collective Cell Migration is Controlled by a Vinculin Mechanochemical Switch. bioRxiv. 2023;: pubmed publisher |
Chakraborty S, Bhat A, Mushtaq I, Luan H, Kalluchi A, Mirza S, et al. EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. bioRxiv. 2023;: pubmed publisher |
Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka T, et al. MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy. bioRxiv. 2023;: pubmed publisher |
Choi K, Ko C, An S, Cho S, Rowland D, Kim J, et al. Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT. Mol Metab. 2023;69:101679 pubmed publisher |
Najm F, DeWeirdt P, Moore M, Bevill S, El Farran C, Macias K, et al. Chromatin complex dependencies reveal targeting opportunities in leukemia. Nat Commun. 2023;14:448 pubmed publisher |
Yang Y, Ni M, Zong R, Yu M, Sun Y, Li J, et al. Targeting Notch1-YAP Circuit Reprograms Macrophage Polarization and Alleviates Acute Liver Injury in Mice. Cell Mol Gastroenterol Hepatol. 2023;15:1085-1104 pubmed publisher |
Hsieh E, Janssens D, Paddison P, Browne E, Henikoff S, OhAinle M, et al. A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. PLoS Pathog. 2023;19:e1011101 pubmed publisher |
Liu Z, Choksi S, Kwon H, Jiao D, Liu C, Liu Z. Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity. Breast Cancer Res. 2023;25:10 pubmed publisher |
Mahapatra K, Mishra S, Dhiman R, Bhutia S. Stonin 2 activates lysosomal-mTOR axis for cell survival in oral cancer. Toxicol In Vitro. 2023;88:105561 pubmed publisher |
Danielson L, Guijarro M, Menendez S, Higgins B, Sun Q, Mittal K, et al. MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma. PLoS ONE. 2023;18:e0278844 pubmed publisher |
Gallagher E, Holzbaur E. The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. Cell Rep. 2023;42:112037 pubmed publisher |
Boos F, Oo J, Warwick T, G xfc nther S, Izquierdo Ponce J, Lopez M, et al. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Basic Res Cardiol. 2023;118:5 pubmed publisher |
Zhang Y, Rabinovsky R, Wei Z, El Fatimy R, Deforzh E, Luan B, et al. Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma. Mol Ther Nucleic Acids. 2023;31:265-275 pubmed publisher |
Virtanen L, Holm E, Halme M, West G, Lindholm F, Gullmets J, et al. Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress. J Cell Sci. 2023;136: pubmed publisher |
Zhou J, Sarkar M, Okamura K, Harris J, Gudjonsson J, Fitzgerald K. Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). Proc Natl Acad Sci U S A. 2023;120:e2213777120 pubmed publisher |
Yang C, Wang Z, Kang Y, Yi Q, Wang T, Bai Y, et al. Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules. Autophagy. 2023;19:1934-1951 pubmed publisher |
Kolluri A, Li D, Li N, Duan Z, Roberts L, Ho M. Human VH-based chimeric antigen receptor T cells targeting glypican 3 eliminate tumors in preclinical models of HCC. Hepatol Commun. 2023;7:e0022 pubmed publisher |
Hossain M, Cevallos R, Zhang R, Hu K. Attenuating iPSC reprogramming stress with dominant-negative BET peptides. iScience. 2023;26:105889 pubmed publisher |
Young L, Goldstein de Salazar R, Han S, Huang Z, Merk A, Drew M, et al. Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proc Natl Acad Sci U S A. 2023;120:e2208960120 pubmed publisher |
Kabirova M, Reichenstein M, Borovok N, Sheinin A, Gorobets D, Michaelevski I. Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization. Cell Mol Neurobiol. 2023;43:2785-2799 pubmed publisher |
Jeon E, Choi D, Choi S, Won J, Jo Y, Kim H, et al. Enhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules. Bioeng Transl Med. 2023;8:e10362 pubmed publisher |
Peng X, Luo R, Ran X, Guo Y, Yao Y, Qiu M. Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy. Bioorg Chem. 2023;132:106375 pubmed publisher |
Tatavosian R, Donovan M, Galbraith M, Duc H, Szwarc M, Joshi M, et al. Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation. Cell Death Differ. 2023;30:952-965 pubmed publisher |
Luo X, Wang C, Huang Y, Cong S, Tan J, Hou W, et al. Establishment of a neutralization assay for Nipah virus using a high-titer pseudovirus system. Biotechnol Lett. 2023;45:489-498 pubmed publisher |
Majdalani P, Levitas A, Krymko H, Slanovic L, Braiman A, Hadad U, et al. A Missense Variation in PHACTR2 Associates with Impaired Actin Dynamics, Dilated Cardiomyopathy, and Left Ventricular Non-Compaction in Humans. Int J Mol Sci. 2023;24: pubmed publisher |
Yan Y, Zhou Q, Ran X, Lu Q, Zhang C, Peng M, et al. Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology. Int J Mol Sci. 2023;24: pubmed publisher |
Wistner S, Macdonald I, Stanley K, Hathaway N. Characterization of Hepatoma-Derived Growth Factor-Related Protein 2 Interactions with Heterochromatin. Cells. 2023;12: pubmed publisher |
Poschel D, Kehinde Ige M, Klement J, Yang D, Merting A, Savage N, et al. IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes. Cells. 2023;12: pubmed publisher |
Zhang S, Guo M, Jiang X, Tang L, Wu T, Bi G, et al. PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Pharmacol Res. 2023;188:106666 pubmed publisher |
Itah Z, Chaudhry S, Raju Ponny S, Aydemir O, Lee A, Cavanagh Kyros J, et al. HER2-driven breast cancer suppression by the JNK signaling pathway. Proc Natl Acad Sci U S A. 2023;120:e2218373120 pubmed publisher |
Huet Calderwood C, Rivera Molina F, Toomre D, Calderwood D. Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis. Methods Mol Biol. 2023;2608:17-38 pubmed publisher |
Satta T, Li L, Chalasani S, Hu X, Nkwocha J, Sharma K, et al. Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax. Clin Cancer Res. 2023;29:1332-1343 pubmed publisher |
Tsujino T, Takai T, Hinohara K, Gui F, Tsutsumi T, Bai X, et al. CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer. Nat Commun. 2023;14:252 pubmed publisher |
Jiang X, Deng W, Tao S, Tang Z, Chen Y, Tian M, et al. A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma. Cell Discov. 2023;9:7 pubmed publisher |
Islam Z, Saravanan B, Walavalkar K, Farooq U, Singh A, Radhakrishnan S, et al. Active enhancers strengthen insulation by RNA-mediated CTCF binding at chromatin domain boundaries. Genome Res. 2023;33:1-17 pubmed publisher |
R xf8 mer T, Khoder Agha F, Aasted M, de Haan N, Horn S, Dylander A, et al. CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation. Glycobiology. 2023;: pubmed publisher |
Mathis N, Allam A, Kissling L, Marquart K, Schmidheini L, Solari C, et al. Predicting prime editing efficiency and product purity by deep learning. Nat Biotechnol. 2023;: pubmed publisher |
Mendonsa S, von K xfc gelgen N, Dantsuji S, Ron M, Breimann L, Baranovskii A, et al. Massively parallel identification of mRNA localization elements in primary cortical neurons. Nat Neurosci. 2023;26:394-405 pubmed publisher |
Arimoto K, Miyauchi S, Troutman T, Zhang Y, Liu M, Stoner S, et al. Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Nat Commun. 2023;14:251 pubmed publisher |
Qiu H, Makarov V, Bolzenius J, Halstead A, Parker Y, Wang A, et al. KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Cancer Res. 2023;83:814-829 pubmed publisher |
Lehmann J, Caduff N, Krzywi x144 ska E, Stierli S, Salas Bastos A, Loos B, et al. Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma. Sci Adv. 2023;9:eadc8825 pubmed publisher |
Guo Y, Zhang H, Yan C, Shen B, Zhang Y, Guo X, et al. Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction. Nat Chem Biol. 2023;19:468-477 pubmed publisher |
Romero Zamora D, Hayashi M. A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection. Sci Rep. 2023;13:645 pubmed publisher |
Pedrazza L, Martinez Martinez A, S xe1 nchez de Diego C, Valer J, Pimenta Lopes C, Sala Gaston J, et al. HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling. Cell Death Dis. 2023;14:17 pubmed publisher |
Robinson C, Singh G, Kleer M, Katsademas T, Castle E, Boudreau B, et al. Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies. PLoS Pathog. 2023;19:e1011080 pubmed publisher |
Fu Y, Xiong S. Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism. PLoS Pathog. 2023;19:e1011090 pubmed publisher |
Mattis K, Krentz N, Metzendorf C, Abaitua F, Spigelman A, Sun H, et al. Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia. 2023;66:674-694 pubmed publisher |
Kiseleva A, Cheng Y, Smith C, Katz R, Poleshko A. PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina. Nucleus. 2023;14:2165602 pubmed publisher |
Chen Y, Zuo X, Wei Q, Xu J, Liu X, Liu S, et al. Upregulation of LRRC8A by m5C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer. Int J Biol Sci. 2023;19:691-704 pubmed publisher |
Suzuki S, Ando F, Kitagawa S, Hara Y, Fujiki T, Mandai S, et al. ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Commun Biol. 2023;6:29 pubmed publisher |
Law R, Kiepas A, Desta H, Perez Ipi xf1 a E, Parlani M, Lee S, et al. Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement. Sci Adv. 2023;9:eabq6480 pubmed publisher |
Lafferty M, Ayg xfc n N, Patel N, Krupa O, Liang D, Wolter J, et al. MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size. elife. 2023;12: pubmed publisher |
Madhu V, Hernandez Meadows M, Boneski P, Qiu Y, Guntur A, Kurland I, et al. The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc. Autophagy. 2023;19:1821-1843 pubmed publisher |
Das M, Chang Y, Anderson R, Saunders R, Zhang N, Tomberlin C, et al. Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs. Proc Natl Acad Sci U S A. 2023;120:e2215071120 pubmed publisher |
Nitschke L, Hu R, Miller A, Lucas L, Cooper T. Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function. Nucleic Acids Res. 2023;51:1245-1259 pubmed publisher |
Huang Z, Efthymiadou A, Liang N, Fan R, Treuter E. Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4. Nucleic Acids Res. 2023;51:1067-1086 pubmed publisher |
Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, et al. A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer. Cell Death Dis. 2023;14:8 pubmed publisher |
Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, et al. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Cell Stem Cell. 2023;30:52-68.e13 pubmed publisher |
Wu Y, Clark K, Niranjan B, Ch xfc eh A, Horvath L, Taylor R, et al. Integrative characterisation of secreted factors involved in intercellular communication between prostate epithelial or cancer cells and fibroblasts. Mol Oncol. 2023;17:469-486 pubmed publisher |
Omar M, Lauer S, Lau H, Golkowski M, Ong S, Scott J. Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells. STAR Protoc. 2023;4:101992 pubmed publisher |
Unda B, Chalil L, Yoon S, Kilpatrick S, Irwin C, Xing S, et al. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Mol Psychiatry. 2023;: pubmed publisher |
Leon K, Khalid M, Flynn R, Fontaine K, Nguyen T, Kumar G, et al. Nuclear accumulation of host transcripts during Zika Virus Infection. PLoS Pathog. 2023;19:e1011070 pubmed publisher |
Bai W, Zhang Y, Ma J, Du M, Xu H, Wang J, et al. FHL3 promotes the formation of fast glycolytic muscle fibers by interacting with YY1 and muscle glycolytic metabolism. Cell Mol Life Sci. 2023;80:27 pubmed publisher |
Diaz Cuadros M, Miettinen T, Skinner O, Sheedy D, D xed az Garc xed a C, Gapon S, et al. Metabolic regulation of species-specific developmental rates. Nature. 2023;: pubmed publisher |
Luo W, Demidov V, Shen Q, Gir xe3 o H, Chakraborty M, Maiorov A, et al. CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner. Sci Adv. 2023;9:eabq5404 pubmed publisher |
Ge Y, Lu H, Yang B, Woo C. Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells. ACS Chem Biol. 2023;: pubmed publisher |
Chen S, Paul M, Sterner C, Belka G, Wang D, Xu P, et al. PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Breast Cancer Res. 2023;25:1 pubmed publisher |
Bonaud A, Gargowitsch L, Gilbert S, Rajan E, Canales Herrerias P, Stockholm D, et al. Sec22b is a critical and nonredundant regulator of plasma cell maintenance. Proc Natl Acad Sci U S A. 2023;120:e2213056120 pubmed publisher |
Martinez A, Kim A, Flores C, Rahman D, Yang W. Mouse embryonic stem cell-derived motor neurons are susceptible to ferroptosis. FEBS Open Bio. 2023;: pubmed publisher |
Yoon D, Kim E, Cho S, Jung S, Lee K, Park K, et al. RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes. Int J Biol Sci. 2023;19:13-33 pubmed publisher |
Lin D, Li X, Moult E, Park P, Tang B, Shen H, et al. Time-tagged ticker tapes for intracellular recordings. Nat Biotechnol. 2023;: pubmed publisher |
Amodio V, Lamba S, Chil xe0 R, Cattaneo C, Mussolin B, Corti G, et al. Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance. Cancer Cell. 2023;41:196-209.e5 pubmed publisher |
Brookes E, Martínez De la Cruz B, Boulasiki P, Au H, Varsally W, Barrington C, et al. A novel intergenic enhancer that regulates Bdnf expression in developing cortical neurons. iScience. 2023;26:105695 pubmed publisher |
Wu C, Lidsky P, Xiao Y, Cheng R, Lee I, Nakayama T, et al. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Cell. 2023;186:112-130.e20 pubmed publisher |
Wang Z, Zhong K, Wang G, Lu Q, Li H, Wu Z, et al. Loss of furin site enhances SARS-CoV-2 spike protein pseudovirus infection. Gene. 2023;856:147144 pubmed publisher |
Vierbuchen T, Agarwal S, Johnson J, Galia L, Lei X, Stein K, et al. The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. Proc Natl Acad Sci U S A. 2023;120:e2213715120 pubmed publisher |
Cervia L, Shibue T, Borah A, Gaeta B, He L, Leung L, et al. A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas. Cancer Discov. 2023;13:766-795 pubmed publisher |
Sun X, Klingbeil O, Lu B, Wu C, Ballon C, Ouyang M, et al. BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network. Nature. 2023;613:195-202 pubmed publisher |
Diab A, Wigerius M, Quinn D, Qi J, Shahin I, Paffile J, et al. NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation. J Neurosci. 2023;43:885-901 pubmed publisher |
Grand K, Stoltz M, Rizzo L, R xf6 ck R, Kaminski M, Salinas G, et al. HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes. J Am Soc Nephrol. 2023;34:412-432 pubmed publisher |
Kato H, Tateishi K, Iwadate D, Yamamoto K, Fujiwara H, Nakatsuka T, et al. HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers. Cancer Sci. 2023;114:1672-1685 pubmed publisher |
Morelli K, Wu Q, Gosztyla M, Liu H, Yao M, Zhang C, et al. An RNA-targeting CRISPR-Cas13d system alleviates disease-related phenotypes in Huntington's disease models. Nat Neurosci. 2023;26:27-38 pubmed publisher |
Wang M, Liu Y, Wang Z, Qiao L, Ma X, Hu L, et al. An Optogenetic-Controlled Cell Reprogramming System for Driving Cell Fate and Light-Responsive Chimeric Mice. Adv Sci (Weinh). 2023;10:e2202858 pubmed publisher |
Taslim T, Hussein A, Keshri R, Ishibashi J, Chan T, Nguyen B, et al. Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs. Stem Cell Reports. 2023;18:269-288 pubmed publisher |
Lidstr xf6 m T, Cumming J, Gaur R, Fr xe4 ngsmyr L, Pateras I, Mickert M, et al. Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer. Cancer Immunol Res. 2023;11:72-92 pubmed publisher |
Bacalhau M, Ferreira F, Kmit A, Souza F, da Silva V, Pimentel A, et al. Identification of novel F508del-CFTR traffic correctors among triazole derivatives. Eur J Pharmacol. 2023;938:175396 pubmed publisher |
Miyazaki M, Nakabo A, Nagano Y, Nagamura Y, Yanagihara K, Ohki R, et al. Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis. Cancer Lett. 2023;553:215983 pubmed publisher |
Binda O, Juillard F, Ducassou J, Kleijwegt C, Paris G, Didillon A, et al. SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members. Life Sci Alliance. 2023;6: pubmed publisher |
Polanco J, Akimov Y, Fernandes A, Briner A, Hand G, van Roijen M, et al. CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Life Sci Alliance. 2023;6: pubmed publisher |
Juras P, Racioppi L, Mukherjee D, Artham S, Gao X, Akullian D Agostino L, et al. Increased CaMKK2 Expression Is an Adaptive Response That Maintains the Fitness of Tumor-Infiltrating Natural Killer Cells. Cancer Immunol Res. 2023;11:109-122 pubmed publisher |
Vinothkumar K, Chanda S, Singh V, Biswas S, Mohapatra S, Biswas G, et al. EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells. Int J Hematol. 2023;117:110-120 pubmed publisher |
Soto Feliciano Y, S xe1 nchez Rivera F, Perner F, Barrows D, Kastenhuber E, Ho Y, et al. A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Cancer Discov. 2023;13:146-169 pubmed publisher |
Muscolini M, Hiscott J, Tassone E. A Genome-Wide CRISPR-Cas9 Loss-of-Function Screening to Identify Host Restriction Factors Modulating Oncolytic Virotherapy. Methods Mol Biol. 2023;2589:379-399 pubmed publisher |
Cheng R, Li F, Zhang M, Xia X, Wu J, Gao X, et al. A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. Cell Res. 2023;33:30-45 pubmed publisher |
Sloat S, Hoppins S. A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering. Life Sci Alliance. 2023;6: pubmed publisher |
Yang Y, Wu C, Wang X, Deng J, Cao W, Tang Y, et al. Targeting inflammatory macrophages rebuilds therapeutic efficacy of DOT1L inhibition in hepatocellular carcinoma. Mol Ther. 2023;31:105-118 pubmed publisher |
Benaglio P, Zhu H, Okino M, Yan J, Elgamal R, Nariai N, et al. Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines. Cell Genom. 2022;2:100214 pubmed publisher |
Csukasi F, Bosakova M, Bárta T, Martin J, Arcedo J, Barad M, et al. Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Front Cell Dev Biol. 2022;10:963389 pubmed publisher |
Worel N, Grabmeier Pfistershammer K, Kratzer B, Schlager M, Tanzmann A, Rottal A, et al. The frequency of differentiated CD3+CD27-CD28- T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma. Front Immunol. 2022;13:1004703 pubmed publisher |
Cappelletto A, Allan H, Crescente M, Schneider E, Bussani R, Ali H, et al. SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity. Front Cardiovasc Med. 2022;9:1013262 pubmed publisher |
Keys H, Knouse K. Genome-scale CRISPR screening in a single mouse liver. Cell Genom. 2022;2: pubmed publisher |
Park J, Park G, Lee J, Park J, Kim S, Kim E, et al. ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth. Front Mol Biosci. 2022;9:1030725 pubmed publisher |
Alannan M, Tr xe9 z xe9 guet V, Amo xea do N, Rossignol R, Mahfouf W, Rezvani H, et al. Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer. Cancers (Basel). 2022;15: pubmed publisher |
George A, Ravi N, Prasad K, Panigrahi L, Koikkara S, Rajendiran V, et al. Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2. Front Genome Ed. 2022;4:1085111 pubmed publisher |
Balta E, Janzen N, Kirchgessner H, Toufaki V, Orlik C, Liang J, et al. Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment. Front Immunol. 2022;13:1063313 pubmed publisher |
Palermo E, Alexandridi M, Di Carlo D, Muscolini M, Hiscott J. Virus-like particle - mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection. Front Cell Infect Microbiol. 2022;12:1079926 pubmed publisher |
Jiang X, Isogai T, Chi J, Danuser G. Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes. PLoS Comput Biol. 2022;18:e1009667 pubmed publisher |
Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K. p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Cell Death Discov. 2022;8:502 pubmed publisher |
Hennig P, Di Filippo M, Bilfeld G, Mellett M, Beer H. High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells. Cell Death Dis. 2022;13:1077 pubmed publisher |
Kim M, Park J, Kim S, Han D, Shin B, Sch xf6 ler H, et al. Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors. Int J Stem Cells. 2022;: pubmed publisher |
Iyer K, Mitra A, Mitra D. Identification of 5' upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection. Virus Res. 2022;324:199034 pubmed publisher |
Wu R, Lao X, Chen D, Qin H, Mu M, Cao W, et al. Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma. Immunity. 2022;: pubmed publisher |
Xu X, Chan A, Li M, Liu Q, Mattson N, Pangeni Pokharel S, et al. ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Sci Adv. 2022;8:eadc8911 pubmed publisher |
Hou Y, Cai Y, Li W, He W, Zhao Z, Zhu W, et al. A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun. 2022;13:7898 pubmed publisher |
van Vliet V, Huynh N, Pal xe0 J, Patel A, Singer A, Slater C, et al. Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. PLoS Pathog. 2022;18:e1011065 pubmed publisher |
Rottner A, Ye Y, Navarro Guerrero E, Rajesh V, Pollner A, Bevacqua R, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Nat Genet. 2022;: pubmed publisher |
Baker S, Meistermann H, Tzouros M, Baker A, Golling S, Polster J, et al. Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus. PLoS Biol. 2022;20:e3001934 pubmed publisher |
Hosios A, Wilkinson M, McNamara M, Kalafut K, Torrence M, Asara J, et al. mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nat Metab. 2022;4:1792-1811 pubmed publisher |
Dolliver S, Kleer M, Bui Marinos M, Ying S, Corcoran J, Khaperskyy D. Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. PLoS Pathog. 2022;18:e1011041 pubmed publisher |
Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, et al. KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell. 2022;: pubmed publisher |
Hou J, Liang S, Xu C, Wei Y, Wang Y, Tan Y, et al. Single-cell CRISPR immune screens reveal immunological roles of tumor intrinsic factors. NAR Cancer. 2022;4:zcac038 pubmed publisher |
Yu B, Shi Q, Belk J, Yost K, Parker K, Li R, et al. Engineered cell entry links receptor biology with single-cell genomics. Cell. 2022;185:4904-4920.e22 pubmed publisher |
Sessions D, Kim K, Kashatus J, Churchill N, Park K, Mayo M, et al. Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma. Cell Rep. 2022;41:111818 pubmed publisher |
Brewer W, Xet Mull A, Yu A, Sweeney M, Walton E, Tobin D. Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. Cell Rep. 2022;41:111817 pubmed publisher |
Kohler J, Omachi K, Charu V, Miner J, Bhalla V. A COL4A4-G394S Variant and Impaired Collagen IV Trimerization in a Patient with Mild Alport Syndrome. Kidney360. 2022;3:1899-1908 pubmed publisher |
Zhang Y, Wei W, Li C, Yan S, Wang S, Xiao S, et al. Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. Cell Death Dis. 2022;13:1034 pubmed publisher |
Ye Q, Hickey J, Summers K, Falatovich B, Gencheva M, Eubank T, et al. Multi-Omics Immune Interaction Networks in Lung Cancer Tumorigenesis, Proliferation, and Survival. Int J Mol Sci. 2022;23: pubmed publisher |
Skobeleva K, Shalygin A, Mikhaylova E, Guzhova I, Ryazantseva M, Kaznacheyeva E. The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2022;23: pubmed publisher |
Li Y, Zhao Y, Yan X, Ye C, Weirich S, Zhang B, et al. CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation. Nat Commun. 2022;13:7636 pubmed publisher |
Santhana Kumar K, Brunner C, Schuster M, Kopp L, Gries A, Yan S, et al. Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth. Cell Oncol (Dordr). 2022;: pubmed publisher |
Ash M, Bhimalli P, Cho B, Mattamana B, Gambut S, Tarhoni I, et al. Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response. Cell Rep. 2022;41:111799 pubmed publisher |
Gialesaki S, Br xe4 uer Hartmann D, Issa H, Bhayadia R, Alejo Valle O, Verboon L, et al. RUNX1 isoform disequilibrium promotes the development of trisomy 21 associated myeloid leukemia. Blood. 2022;: pubmed publisher |
Kriachkov V, Ormsby A, Kusnadi E, McWilliam H, Mintern J, Amarasinghe S, et al. Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. J Biol Chem. 2022;299:102774 pubmed publisher |
Xiong Q, Cao L, Ma C, Tortorici M, Liu C, Si J, et al. Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Nature. 2022;612:748-757 pubmed publisher |
Dai T, Rosario S, Katsuta E, Sawant Dessai A, Paterson E, Novickis A, et al. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022;41:111756 pubmed publisher |
Wang Y, Zhao Y, Guo W, Yadav G, Bhaskarla C, Wang Z, et al. Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response. Sci Adv. 2022;8:eadd0005 pubmed publisher |
Peng N, Kang H, Feng Y, Minikes A, Jiang X. Autophagy inhibition signals through senescence to promote tumor suppression. Autophagy. 2022;:1-17 pubmed publisher |
Ib xe1 xf1 ez Molero S, van Vliet A, Poźniak J, Hummelink K, Terry A, Monkhorst K, et al. SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response. Oncoimmunology. 2022;11:2139074 pubmed publisher |
Devlin A, Shukla A, Ruiz J, Barnes S, Govindan A, Hunter O, et al. The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication. Nat Commun. 2022;13:7447 pubmed publisher |
Liu X, Sato N, Yabushita T, Li J, Jia Y, Tamura M, et al. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO Mol Med. 2022;:e15631 pubmed publisher |
Kneppers J, Severson T, Siefert J, Schol P, Joosten S, Yu I, et al. Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential. Nat Commun. 2022;13:7367 pubmed publisher |
Hoshii T, Perlee S, Kikuchi S, Rahmutulla B, Fukuyo M, Masuda T, et al. SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia. Cell Rep. 2022;41:111727 pubmed publisher |
Xiong Y, Zhong Y, Yim H, Yang X, Park K, Xie L, et al. Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets. J Am Chem Soc. 2022;144:22622-22632 pubmed publisher |
Fleck A, Flotte A, Si E, Mu D. Loss of Gap Junction Factor Connexin 43 Results in an Increase of Exosomal Tetraspanins in Human Lung Cancer Cell Line A549. MicroPubl Biol. 2022;2022: pubmed publisher |
van den Elzen A, Watson M, Thoreen C. mRNA 5' terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay. PLoS Genet. 2022;18:e1010532 pubmed publisher |
Jia S, Zhuo R, Zhang Z, Yang Y, Tao Y, Wang J, et al. The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma. J Immunol Res. 2022;2022:7945884 pubmed publisher |
Yi C, He J, Huang D, Zhao Y, Zhang C, Ye X, et al. Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. Cell Death Dis. 2022;13:1004 pubmed publisher |
Radke J, Schumann E, Onken J, Koll R, Acker G, Bodnar B, et al. Decoding molecular programs in melanoma brain metastases. Nat Commun. 2022;13:7304 pubmed publisher |
Liu J, Zeng D, Luo J, Wang H, Xiong J, Chen X, et al. LPS-Induced Inhibition of miR-143 Expression in Brown Adipocytes Promotes Thermogenesis and Fever. Int J Mol Sci. 2022;23: pubmed publisher |
Cao F, Yang D, Tang F, Lu C, He X, Chen S, et al. Girdin Promotes Tumorigenesis and Chemoresistance in Lung Adenocarcinoma by Interacting with PKM2. Cancers (Basel). 2022;14: pubmed publisher |
Cao Y, Yan X, Bai X, Tang F, Si P, Bai C, et al. UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling. Cancers (Basel). 2022;14: pubmed publisher |
Mendon N, Ganie R, Kesarwani S, Dileep D, Sasi S, Lama P, et al. Nanobody derived using a peptide epitope from the spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants. J Biol Chem. 2022;299:102732 pubmed publisher |
Liu H, Lee C, Hsieh Y, Zheng J, Liu Y, Chang C, et al. Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo. Genes (Basel). 2022;13: pubmed publisher |
Farnsworth D, Inoue Y, Johnson F, de Rappard Yuswack G, Lu D, Shi R, et al. MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression. NPJ Precis Oncol. 2022;6:88 pubmed publisher |
Rodrigues Lopes I, Alcântara L, Silva R, Josse J, Vega E, Cabrerizo A, et al. Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature. Nat Commun. 2022;13:7174 pubmed publisher |
Chen Q, Dai J, Bian Q. Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects. Sci Adv. 2022;8:eabo3648 pubmed publisher |
Li X, Anderson D, Chang Y, Jarnik M, Machner M. VpdC is a ubiquitin-activated phospholipase effector that regulates Legionella vacuole expansion during infection. Proc Natl Acad Sci U S A. 2022;119:e2209149119 pubmed publisher |
Tesfay L, Paul B, Hegde P, Brewer M, Habbani S, JELLISON E, et al. Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer. Sci Rep. 2022;12:19936 pubmed publisher |
Taiko I, Takano C, Nomoto M, Hayashida S, Kanemaru K, Miki T. Selection of red fluorescent protein for genetic labeling of mitochondria and intercellular transfer of viable mitochondria. Sci Rep. 2022;12:19841 pubmed publisher |
Hsu K, Dunleavey J, Szot C, Yang L, Hilton M, Morris K, et al. Cancer cell survival depends on collagen uptake into tumor-associated stroma. Nat Commun. 2022;13:7078 pubmed publisher |
Rushdi M, Pan V, Li K, Choi H, Travaglino S, Hong J, et al. Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity. Nat Commun. 2022;13:7055 pubmed publisher |
Celebi Torabfam G, Yetisgin A, Erdem C, Cayli A, Kutlu O, Cetinel S. A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells. Cytotechnology. 2022;74:635-655 pubmed publisher |
Corliss L, Holliday M, Lennemann N. Dual-fluorescent reporter for live-cell imaging of the ER during DENV infection. Front Cell Infect Microbiol. 2022;12:1042735 pubmed publisher |
McNamara M, Hosios A, Torrence M, Zhao T, Fraser C, Wilkinson M, et al. Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex. iScience. 2022;25:105458 pubmed publisher |
SCHMITT M, Ceteci F, Gupta J, Pesic M, B xf6 ttger T, Nicolas A, et al. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Nature. 2022;612:347-353 pubmed publisher |
Darragh L, Gadwa J, Pham T, Van Court B, Neupert B, Olimpo N, et al. Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors. Nat Commun. 2022;13:7015 pubmed publisher |
Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, et al. SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. PLoS Biol. 2022;20:e3001871 pubmed publisher |
Pesch A, Chandler B, Michmerhuizen A, Carter H, Hirsh N, Wilder Romans K, et al. Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression. Cancer Res Commun. 2022;2:679-693 pubmed publisher |
Gong Y, Shao H, Li Y, Brafford P, Stine Z, Sun J, et al. Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells. Cancer Res Commun. 2022;2:842-856 pubmed publisher |
Washer S, Perez Alcantara M, Chen Y, Steer J, James W, Trynka G, et al. Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia. Sci Rep. 2022;12:19454 pubmed publisher |
Suzuki C, Fujiwara T, Shima H, Ono K, Saito K, Kato H, et al. Elucidation of the Role of FAM210B in Mitochondrial Metabolism and Erythropoiesis. Mol Cell Biol. 2022;42:e0014322 pubmed publisher |
Shozu K, Kaneko S, Shinkai N, Dozen A, Kosuge H, Nakakido M, et al. Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer. Clin Epigenetics. 2022;14:147 pubmed publisher |
Angulo M, Bertalovitz A, Argenziano M, Yang J, Patel A, Zesiewicz T, et al. Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC-neurons and cardiomyocytes. Mol Genet Genomic Med. 2022;:e2093 pubmed publisher |
Tilokani L, Russell F, Hamilton S, Virga D, Segawa M, Paupe V, et al. AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. Sci Adv. 2022;8:eabo7956 pubmed publisher |
Pickering B, Lung O, Maguire F, Kruczkiewicz P, Kotwa J, Buchanan T, et al. Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission. Nat Microbiol. 2022;7:2011-2024 pubmed publisher |
Kocaturk N, Peker N, Eberhart K, Akkoç Y, Deveci G, Dengjel J, et al. Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Cell Death Dis. 2022;13:947 pubmed publisher |
Kitaeva K, Chulpanova D, Zhuravleva M, Filin I, Deviatiiarov R, Ballard Reisch A, et al. Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells. Bioengineering (Basel). 2022;9: pubmed publisher |
Yi J, Gong X, Yin X, Wang L, Hou J, Chen J, et al. Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells. Front Oncol. 2022;12:988528 pubmed publisher |
Ci Y, Yao B, Yue K, Yang Y, Xu C, Li D, et al. Bortezomib inhibits ZIKV/DENV by interfering with viral polyprotein cleavage via the ERAD pathway. Cell Chem Biol. 2022;: pubmed publisher |
Yoo H, Choi D, Roh Y, Lee Y, Lim J, Eo S, et al. MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation. Cell Rep. 2022;41:111598 pubmed publisher |
Chen P, Fiaux P, Zhang K, Li B, Kubo N, Jiang S, et al. Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation. Cell Rep. 2022;41:111630 pubmed publisher |
Mori Y, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, et al. Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry. MBio. 2022;13:e0169822 pubmed publisher |
Xu T, Verhagen M, Joosten R, Sun W, Sacchetti A, Munoz Sagredo L, et al. Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer. elife. 2022;11: pubmed publisher |
Crow J, Samuel G, Farrow E, Gibson M, Johnston J, Guest E, et al. MicroRNA Content of Ewing Sarcoma Derived Extracellular Vesicles Leads to Biomarker Potential and Identification of a Previously Undocumented EWS-FLI1 Translocation. Biomark Insights. 2022;17:11772719221132693 pubmed publisher |
Rouger Gaudichon J, Cousin E, Jakobczyk H, Debaize L, Rio A, Forestier A, et al. Hypoxia regulates CD9 expression and dissemination of B lymphoblasts. Leuk Res. 2022;123:106964 pubmed publisher |
Liu S, Cao Y, Cui K, Tang Q, Zhao K. Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops. Nat Commun. 2022;13:6679 pubmed publisher |
Archer S, Dasgupta A, Chen K, Wu D, Baid K, Mamatis J, et al. SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia. Redox Biol. 2022;58:102508 pubmed publisher |
Sun P, Zhang Z, Wang B, Liu C, Chen C, Liu P, et al. A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun. 2022;13:6562 pubmed publisher |
Grange L, Reynolds J, Ullah F, Isidor B, Shearer R, Latypova X, et al. Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy. Nat Commun. 2022;13:6664 pubmed publisher |
Sevin xe7 K, Sevin xe7 G, Cavga A, Philpott M, Kelek xe7 i S, Can H, et al. BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming. Stem Cell Reports. 2022;17:2629-2642 pubmed publisher |
Loukas I, Simeoni F, Milan M, Inglese P, Patel H, Goldstone R, et al. Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia. Cancer Cell. 2022;: pubmed publisher |
Kantzer C, Yang W, Grommisch D, Vikhe Patil K, Mak K, Shirokova V, et al. ID1 and CEBPA coordinate epidermal progenitor cell differentiation. Development. 2022;149: pubmed publisher |
Hanzl A, Casement R, Imrichová H, Hughes S, Barone E, Testa A, et al. Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat Chem Biol. 2022;: pubmed publisher |
Kim H, Leng K, Park J, Sorets A, Kim S, Shostak A, et al. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat Commun. 2022;13:6581 pubmed publisher |
Yang S, Yamazaki S, Cox K, Huang Y, Miller E, Takahashi J. Coupling-dependent metabolic ultradian rhythms in confluent cells. Proc Natl Acad Sci U S A. 2022;119:e2211142119 pubmed publisher |
Singer J, Shew T, Ferguson D, Renkemeyer M, Pietka T, Hall A, et al. Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice. Obesity (Silver Spring). 2022;30:2122-2133 pubmed publisher |
Dzhivhuho G, Holsey J, Honeycutt E, O Farrell H, Rekosh D, Hammarskjold M, et al. HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev. Sci Rep. 2022;12:18416 pubmed publisher |
Le Pann xe9 rer M, Diesch J, Casquero R, Maher M, García O, Haferlach T, et al. Different Gene Sets Are Associated With Azacitidine Response In Vitro Versus in Myelodysplastic Syndrome Patients. Hemasphere. 2022;6:e792 pubmed publisher |
Muto Y, DIXON E, Yoshimura Y, Wu H, Omachi K, Ledru N, et al. Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis. Nat Commun. 2022;13:6497 pubmed publisher |
Cadavid J, Latour S, Nowlan F, Co I, Landon Brace N, Wouters B, et al. An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype. Adv Healthc Mater. 2022;:e2201846 pubmed publisher |
Paris A, Tardif N, Baietti F, Berra C, Leclair H, Leucci E, et al. The AhR-SRC axis as a therapeutic vulnerability in BRAFi-resistant melanoma. EMBO Mol Med. 2022;14:e15677 pubmed publisher |
Dai Q, Zhang L, Sun H, Pajdzik K, Yang L, Ye C, et al. Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution. Nat Biotechnol. 2022;: pubmed publisher |
Cavounidis A, Pandey S, Capitani M, Friedrich M, Cross A, Gartner L, et al. Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism. Mucosal Immunol. 2022;15:1431-1446 pubmed publisher |
Stern A, Smith G, Santos L, Sarmah D, Zhang X, Lu X, et al. Relating individual cell division events to single-cell ERK and Akt activity time courses. Sci Rep. 2022;12:18077 pubmed publisher |
Kono Y, Adam S, Sato Y, Reddy K, Zheng Y, Medalia O, et al. Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS. J Cell Biol. 2022;221: pubmed publisher |
Filimonov A, Yarovaya O, Zaykovskaya A, Rudometova N, Shcherbakov D, Chirkova V, et al. (+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses. Viruses. 2022;14: pubmed publisher |
Jim xe9 nez Villegas J, Kirby J, Mata A, Cadenas S, Turner M, Malaspina A, et al. Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance. Antioxidants (Basel). 2022;11: pubmed publisher |
Lu Y, Zhu Q, Fox D, Gao C, Stanley S, Luo K. SARS-CoV-2 down-regulates ACE2 through lysosomal degradation. Mol Biol Cell. 2022;33:ar147 pubmed publisher |
Yenkin A, Bramley J, Kremitzki C, Waligorski J, Liebeskind M, Xu X, et al. Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations. Commun Biol. 2022;5:1128 pubmed publisher |
O Brien S, Kelso S, Steinhart Z, Orlicky S, Mis M, Kim Y, et al. SCFFBXW7 regulates G2-M progression through control of CCNL1 ubiquitination. EMBO Rep. 2022;23:e55044 pubmed publisher |
Li M, Han Y, Wang C, Kang W, Jiang W, Zhang L, et al. Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma. J Exp Clin Cancer Res. 2022;41:311 pubmed publisher |
Nielsen M, de Haan N, Kightlinger W, Ye Z, Dabelsteen S, Li M, et al. Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line. Nat Commun. 2022;13:6257 pubmed publisher |
Zhang X, Jiang Q, Li J, Zhang S, Cao Y, Xia X, et al. KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA-DNA triplexes and HP1 binding. Nat Cell Biol. 2022;24:1617-1629 pubmed publisher |
Wang Y, Leng X, Zhou C, Lu S, Tsang C, Xu J, et al. Non-enzymatic role of SOD1 in intestinal stem cell growth. Cell Death Dis. 2022;13:882 pubmed publisher |
Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, et al. Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Cell Rep. 2022;41:111514 pubmed publisher |
Zhang H, Tomar V, Li J, Basavaraja R, Yan F, Gui J, et al. Protection of Regulatory T Cells from Fragility and Inactivation in the Tumor Microenvironment. Cancer Immunol Res. 2022;10:1490-1505 pubmed publisher |
Wehling L, Keegan L, Fern xe1 ndez Palanca P, Hassan R, Ghallab A, Schmitt J, et al. Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury. elife. 2022;11: pubmed publisher |
Jin R, Niu C, Wu F, Zhou S, Han T, Zhang Z, et al. DNA damage contributes to age-associated differences in SARS-CoV-2 infection. Aging Cell. 2022;21:e13729 pubmed publisher |
Benlarbi M, Laroche G, Fink C, Fu K, Mulloy R, Phan A, et al. Identification and differential usage of a host metalloproteinase entry pathway by SARS-CoV-2 Delta and Omicron. iScience. 2022;25:105316 pubmed publisher |
Cao G, Ma L, Zhang Z, Wang X, Hua J, Zhang J, et al. Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors. Acta Pharmacol Sin. 2022;: pubmed publisher |
Zhang Y, Li Y, Thompson K, Stoletov K, Yuan Q, Bera K, et al. Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis. Nat Commun. 2022;13:6128 pubmed publisher |
Chen S, Ma B, Li X, Zhang K, Wei Y, Du B, et al. MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling. iScience. 2022;25:105176 pubmed publisher |
Chen C, Zhang Z, Liu C, Wang B, Liu P, Fang S, et al. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Nat Commun. 2022;13:6108 pubmed publisher |
Sala Gaston J, Pedrazza L, Ramirez J, Martinez Martinez A, Rawlins L, Baple E, et al. HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress. Cell Mol Life Sci. 2022;79:548 pubmed publisher |
Zhang M, Kuznetsoff J, Owens D, Gallo R, Kalahasty K, Cruz A, et al. Early Mechanisms of Chemoresistance in Retinoblastoma. Cancers (Basel). 2022;14: pubmed publisher |
Wang C, Tian W, Hu S, Di C, He C, Cao Q, et al. Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells. Cell Death Dis. 2022;13:866 pubmed publisher |
Zhao F, Xu F, Liu X, Hu Y, Wei L, Fan Z, et al. SERINC5 restricts influenza virus infectivity. PLoS Pathog. 2022;18:e1010907 pubmed publisher |
Kuan M, Caruso L, Zavala A, Rana P, O Dowd J, Tempera I, et al. Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate the Basement Membrane Protein Nidogen 1. J Virol. 2022;96:e0133622 pubmed publisher |
Ma L, Mei Y, Xu P, Cheng Y, You Z, Ji X, et al. Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors. iScience. 2022;25:105172 pubmed publisher |
Durrant M, Fanton A, Tycko J, Hinks M, Chandrasekaran S, Perry N, et al. Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome. Nat Biotechnol. 2022;: pubmed publisher |
Markhard A, McCoy J, To T, Mootha V. A genetically encoded system for oxygen generation in living cells. Proc Natl Acad Sci U S A. 2022;119:e2207955119 pubmed publisher |
Colbert J, Cruz F, Baer C, Rock K. Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Proc Natl Acad Sci U S A. 2022;119:e2122188119 pubmed publisher |
Lemay J, St Hilaire E, Ronato D, Gao Y, B xe9 langer F, Gezzar Dandashi S, et al. A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response. PLoS Biol. 2022;20:e3001543 pubmed publisher |
Sharma G, Banerjee S. Activity-regulated E3 ubiquitin ligase TRIM47 modulates excitatory synapse development. Front Mol Neurosci. 2022;15:943980 pubmed publisher |
Wang X, Liu Y, Ding Y, Feng G. CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway. Sci Rep. 2022;12:16899 pubmed publisher |
Boland S, Swarup S, Ambaw Y, Malia P, Richards R, Fischer A, et al. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022;13:5924 pubmed publisher |
Li L, Ding P, Lv X, Xie S, Li L, Chen J, et al. CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T-cell Immunity. Cancer Immunol Res. 2022;10:1475-1489 pubmed publisher |
Pattwell S, Arora S, Nuechterlein N, Zager M, Loeb K, Cimino P, et al. Oncogenic role of a developmentally regulated NTRK2 splice variant. Sci Adv. 2022;8:eabo6789 pubmed publisher |
Ghalali A, Wang L, Stopsack K, Rice J, Wu S, Wu C, et al. AZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer. Exp Mol Med. 2022;54:1713-1726 pubmed publisher |
Zhang Z, Ding Y, Ezhilarasan R, Lhakhang T, Wang Q, Yang J, et al. Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma. Cell Discov. 2022;8:102 pubmed publisher |
Thaler R, Khani F, Sturmlechner I, Dehghani S, Denbeigh J, Zhou X, et al. Vitamin C epigenetically controls osteogenesis and bone mineralization. Nat Commun. 2022;13:5883 pubmed publisher |
Sasaya T, Kubo T, Murata K, Mizue Y, Sasaki K, Yanagawa J, et al. Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma. Cancer Med. 2022;: pubmed publisher |
Sivagurunathan S, Vahabikashi A, Yang H, Zhang J, Vazquez K, Rajasundaram D, et al. Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells. Front Cell Dev Biol. 2022;10:929495 pubmed publisher |
Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, et al. Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration. iScience. 2022;25:105050 pubmed publisher |
Willis J, Berndsen Z, Ma K, Steichen J, Schiffner T, Landais E, et al. Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity. 2022;55:2149-2167.e9 pubmed publisher |
Hino N, Matsuda K, Jikko Y, Maryu G, Sakai K, Imamura R, et al. A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. Dev Cell. 2022;57:2290-2304.e7 pubmed publisher |
Li Q, Humphries F, Girardin R, Wallace A, Ejemel M, Amcheslavsky A, et al. Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants. Front Immunol. 2022;13:995412 pubmed publisher |
Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Castro L, et al. Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. bioRxiv. 2022;: pubmed publisher |
Liang X, Zhang Y, He Y, Liu X, Ding Z, Zhang X, et al. A cancer stem cell associated gene signature for predicting overall survival of hepatocellular carcinoma. Front Genet. 2022;13:888601 pubmed publisher |
Carter C, Mast F, Olivier J, Bourgeois N, Kaushansky A, Aitchison J. Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication. Front Cell Infect Microbiol. 2022;12:979996 pubmed publisher |
Ma L, Wang J, Zhang Y, Fang F, Ling J, Chu X, et al. BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes. Cancer Biol Ther. 2022;23:1-15 pubmed publisher |
Haridhasapavalan K, Sundaravadivelu P, Joshi N, Das N, Mohapatra A, Voorkara U, et al. Generation of a recombinant version of a biologically active cell-permeant human HAND2 transcription factor from E. coli. Sci Rep. 2022;12:16129 pubmed publisher |
Ambrosini C, Destefanis E, Kheir E, Broso F, Alessandrini F, Longhi S, et al. Translational enhancement by base editing of the Kozak sequence rescues haploinsufficiency. Nucleic Acids Res. 2022;50:10756-10771 pubmed publisher |
Trolle J, McBee R, Kaufman A, Pinglay S, Berger H, German S, et al. Resurrecting essential amino acid biosynthesis in mammalian cells. elife. 2022;11: pubmed publisher |
Cronk J, Dziewulska K, Puchalski P, Crittenden R, Hammarskj xf6 ld M, Brown M. Altered-Self MHC Class I Sensing via Functionally Disparate Paired NK Cell Receptors Counters Murine Cytomegalovirus gp34-Mediated Immune Evasion. J Immunol. 2022;209:1545-1554 pubmed publisher |
Escobar M, Li J, Patel A, Liu S, Xu Q, Hilton I. Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells. ACS Synth Biol. 2022;11:3239-3250 pubmed publisher |
Bao C, Duan J, Xie Y, Liu Y, Li P, Li J, et al. A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Mol Ther Nucleic Acids. 2022;29:836-851 pubmed publisher |
Salimi Jeda A, Esghaei M, Hossein Keyvani -, Bokharaei Salim F, Teimoori A, Abdoli A. Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy. Heliyon. 2022;8:e10483 pubmed publisher |
Ogden S, Carys K, Ahmed I, Bruce J, Sharrocks A. Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition. Oncogene. 2022;41:4808-4822 pubmed publisher |
M xfc ller P, Rocks O. A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity. STAR Protoc. 2022;3:101705 pubmed publisher |
Jiang A, Zhang S, Wang X, Li D. RBM15 condensates modulate m6A modification of STYK1 to promote tumorigenesis. Comput Struct Biotechnol J. 2022;20:4825-4836 pubmed publisher |
Sperber H, Sutter K, M xfc ller K, M xfc ller P, Schwarzer R. The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity. Viruses. 2022;14: pubmed publisher |
Plavec Z, Domanska A, Liu X, Laine P, Paulin L, Varjosalo M, et al. SARS-CoV-2 Production, Purification Methods and UV Inactivation for Proteomics and Structural Studies. Viruses. 2022;14: pubmed publisher |
Zeng X, Zhao F, Cui G, Zhang Y, Deshpande R, Chen Y, et al. METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Nat Cancer. 2022;3:1088-1104 pubmed publisher |
Badarinath K, Dam B, Kataria S, Zirmire R, Dey R, Kansagara G, et al. Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. Cell Rep. 2022;40:111390 pubmed publisher |
McKinney A, Mathur R, Stevers N, Molinaro A, Chang S, Phillips J, et al. GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. Cell Rep. 2022;40:111344 pubmed publisher |
Ugalde A, Bretones G, Rodr xed guez D, Quesada V, Llorente F, Fern xe1 ndez Delgado R, et al. Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells. EMBO J. 2022;41:e110727 pubmed publisher |
Pringle E, Duguay B, Bui Marinos M, Mulloy R, Landreth S, Desireddy K, et al. Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions. PLoS Pathog. 2022;18:e1010832 pubmed publisher |
Sun D, Llorà Batlle O, van den Ameele J, Thomas J, He P, Lim K, et al. SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling. EMBO J. 2022;41:e111338 pubmed publisher |
Butler M, Vervoort B, van Ingen Schenau D, Jongeneel L, van der Zwet J, Marke R, et al. Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways. Front Oncol. 2022;12:905665 pubmed publisher |
Yang Y, Bolomsky A, Oellerich T, Chen P, Ceribelli M, H xe4 upl B, et al. Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma. Nat Commun. 2022;13:5469 pubmed publisher |
Qi S, Sivakumar S, Yu H. CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation. STAR Protoc. 2022;3:101682 pubmed publisher |
Rebsamen M, Girardi E, Sedlyarov V, Scorzoni S, Papakostas K, Vollert M, et al. Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions. Life Sci Alliance. 2022;5: pubmed publisher |
Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner E, Scherzer M, et al. Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis. Cancer Res. 2022;82:4261-4273 pubmed publisher |
Wuchu F, Ma X, Que Y, Chen J, Ruan Y. Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca2+-modulated cAMP production. Front Cell Dev Biol. 2022;10:781762 pubmed publisher |
Friskes A, Koob L, Krenning L, Severson T, Koeleman E, Vergara X, et al. Double-strand break toxicity is chromatin context independent. Nucleic Acids Res. 2022;50:9930-9947 pubmed publisher |
Khokhlatchev A, Sharma A, Deering T, Shaw J, Costa Pinheiro P, Golla U, et al. Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia. FASEB J. 2022;36:e22514 pubmed publisher |
Shang Y, Sun X, Chen X, Wang Q, Wang E, Miller E, et al. A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease. Acta Neuropathol. 2022;144:911-938 pubmed publisher |
Lauko A, Volovetz J, Turaga S, Bayık D, Silver D, Mitchell K, et al. SerpinB3 drives cancer stem cell survival in glioblastoma. Cell Rep. 2022;40:111348 pubmed publisher |
Sokoya T, Parolek J, Foged M, Danylchuk D, Bozan M, Sarkar B, et al. Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. elife. 2022;11: pubmed publisher |
Glorieux C, Xia X, You X, Wang Z, Han Y, Yang J, et al. Cisplatin and gemcitabine exert opposite effects on immunotherapy with PD-1 antibody in K-ras-driven cancer. J Adv Res. 2022;40:109-124 pubmed publisher |
Ching K, de Vries M, Gago J, Dancel Manning K, Sall J, Rice W, et al. ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection. PLoS Biol. 2022;20:e3001754 pubmed publisher |
Abdul F, Diman A, Baechler B, Ramakrishnan D, Kornyeyev D, Beran R, et al. Smc5/6 silences episomal transcription by a three-step function. Nat Struct Mol Biol. 2022;29:922-931 pubmed publisher |
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, et al. GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Nat Commun. 2022;13:5351 pubmed publisher |
Pond K, Morris J, Alkhimenok O, Varghese R, Cabel C, Ellis N, et al. Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis. elife. 2022;11: pubmed publisher |
Goodnough L, Ambrosi T, Steininger H, Butler M, Hoover M, Choo H, et al. Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs. Front Endocrinol (Lausanne). 2022;13:924927 pubmed publisher |
Li L, Liu Z, Yang H, Li Y, Zeng Q, Chen L, et al. Investigation of novel de novo KCNC2 variants causing severe developmental and early-onset epileptic encephalopathy. Seizure. 2022;101:218-224 pubmed publisher |
Rossotti M, van Faassen H, Tran A, Sheff J, Sandhu J, Duque D, et al. Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models. Commun Biol. 2022;5:933 pubmed publisher |
Wu S, Edwards H, Wang D, Liu S, Qiao X, Carter J, et al. Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia. Cells. 2022;11: pubmed publisher |
Vaquero Siguero N, Schleussner N, Volk J, Mastel M, Meier J, Jackstadt R. Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection. Cancers (Basel). 2022;14: pubmed publisher |
Russell S, Lim F, Peters P, Wardell S, Whitaker R, Chang C, et al. Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer. Cancers (Basel). 2022;14: pubmed publisher |
Francis C, Kincross H, Kushner E. Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis. Nat Commun. 2022;13:5276 pubmed publisher |
Baca S, Singler C, Zacharia S, Seo J, Morova T, Hach F, et al. Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation. Nat Genet. 2022;54:1364-1375 pubmed publisher |
Hojo H, Saito T, He X, Guo Q, Onodera S, Azuma T, et al. Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages. Cell Rep. 2022;40:111315 pubmed publisher |
Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio S, et al. Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma. Acta Neuropathol. 2022;144:1027-1048 pubmed publisher |
Wilson P, Muto Y, Wu H, Karihaloo A, Waikar S, Humphreys B. Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression. Nat Commun. 2022;13:5253 pubmed publisher |
DeWeirdt P, McGee A, Zheng F, Nwolah I, Hegde M, Doench J. Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening. Nat Commun. 2022;13:5255 pubmed publisher |
Pogacar Z, Johnson J, Krenning L, De Conti G, Jochems F, Lieftink C, et al. Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. PLoS ONE. 2022;17:e0273182 pubmed publisher |
Zou R, Marin Gonzalez A, Liu Y, Liu H, Shen L, Dveirin R, et al. Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nat Cell Biol. 2022;24:1433-1444 pubmed publisher |
Tang S, Wu X, Liu J, Zhang Q, Wang X, Shao S, et al. Generation of dual-gRNA library for combinatorial CRISPR screening of synthetic lethal gene pairs. STAR Protoc. 2022;3:101556 pubmed publisher |
Skoko J, Cao J, Gaboriau D, Attar M, Asan A, Hong L, et al. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022;56:102443 pubmed publisher |
Wang C, Yu X, Ding S, Liu Y, Zhang H, Fu J, et al. Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF. Cell Biosci. 2022;12:143 pubmed publisher |
Michaelis J, Brunstein M, Bozkurt S, Alves L, Wegner M, Kaulich M, et al. Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Nat Commun. 2022;13:5164 pubmed publisher |
Xia F, Ma Y, Chen K, Duong B, Ahmed S, Atwal R, et al. Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis. Sci Adv. 2022;8:eabo7792 pubmed publisher |
Li X, Kordsmeier J, Nookaew I, Kim H, Xiong J. Piezo1 stimulates mitochondrial function via cAMP signaling. FASEB J. 2022;36:e22519 pubmed publisher |
Bergmann T, Liu Y, Skov J, Mogus L, Lee J, Pfisterer U, et al. Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming. Front Cell Dev Biol. 2022;10:976549 pubmed publisher |
Yuskaitis C, Modasia J, Schr xf6 tter S, Rossitto L, Groff K, Morici C, et al. DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting. Cell Rep. 2022;40:111278 pubmed publisher |
Choi S, Flamand M, Liu B, Zhu H, Hu M, Wang M, et al. RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Cell Rep. 2022;40:111293 pubmed publisher |
Casteels T, Bajew S, Reini x161 J, Enders L, Schuster M, Fontaine F, et al. SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression. Cell Rep. 2022;40:111288 pubmed publisher |
So J, Mabe N, Englinger B, Chow K, Moyer S, Yerrum S, et al. VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system. JCI Insight. 2022;7: pubmed publisher |
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed publisher |
Martin Gallausiaux C, García Weber D, Lashermes A, Larraufie P, Marinelli L, Teixeira V, et al. Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway. Gut Microbes. 2022;14:2110639 pubmed publisher |
Hou J, Wei Y, Zou J, Jaffery R, Liang S, Zheng C, et al. Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection. Res Sq. 2022;: pubmed publisher |
Rios Garcia M, Meissburger B, Chan J, de Guia R, Mattijssen F, Roessler S, et al. Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death. Adv Sci (Weinh). 2022;9:e2104291 pubmed publisher |
Iketani S, Hong S, Sheng J, Bahari F, Culbertson B, Atanaki F, et al. Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites. Cell Host Microbe. 2022;30:1354-1362.e6 pubmed publisher |
Ochi T, Fujiwara T, Ono K, Suzuki C, Nikaido M, Inoue D, et al. Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome. Sci Rep. 2022;12:14562 pubmed publisher |
Hinds J, Feris E, Wilkins O, Deary L, Wang X, Cole M. S146L in MYC is a context-dependent activating substitution in cancer development. PLoS ONE. 2022;17:e0272771 pubmed publisher |
Zhong G, Wang Q, Wang Y, Guo Y, Xu M, Guan Y, et al. scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity. Oncoimmunology. 2022;11:2114740 pubmed publisher |
Frey K, Goetze S, Rohrer L, von Eckardstein A, Wollscheid B. Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions. Int J Mol Sci. 2022;23: pubmed publisher |
Ariyachet C, Chuaypen N, Kaewsapsak P, Chantaravisoot N, Jindatip D, Potikanond S, et al. MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury. Int J Mol Sci. 2022;23: pubmed publisher |
Zhang M, Qiu H, Mao L, Wang B, Li N, Fan Y, et al. Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells. Cell Death Dis. 2022;13:733 pubmed publisher |
Carnevale J, Shifrut E, Kale N, Nyberg W, Blaeschke F, Chen Y, et al. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022;609:174-182 pubmed publisher |
D Souza L, Wright S, Bhattacharya D. Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters. PLoS ONE. 2022;17:e0261801 pubmed publisher |
Stenvall C, Nystr xf6 m J, Butler Hallissey C, Jansson T, Heikkil xe4 T, Adam S, et al. Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells. Mol Biol Cell. 2022;33:ar121 pubmed publisher |
Kleer M, Mulloy R, Robinson C, Evseev D, Bui Marinos M, Castle E, et al. Human coronaviruses disassemble processing bodies. PLoS Pathog. 2022;18:e1010724 pubmed publisher |
Ibarra I, Ratnu V, Gordillo L, Hwang I, Mariani L, Weinand K, et al. Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements. Mol Syst Biol. 2022;18:e10473 pubmed publisher |
Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, et al. RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1. Autophagy. 2022;:1-17 pubmed publisher |
Patten J, Keiser P, Morselli Gysi D, Menichetti G, Mori H, Donahue C, et al. Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization. iScience. 2022;25:104925 pubmed publisher |
Phillips S, Baek A, Kim S, Chen S, Wu L. Protocol for the generation of HIV-1 genomic RNA with altered levels of N 6-methyladenosine. STAR Protoc. 2022;3:101616 pubmed publisher |
Ross E, Hoeve A, Saeij J, Barragan A. Toxoplasma effector-induced ICAM-1 expression by infected dendritic cells potentiates transmigration across polarised endothelium. Front Immunol. 2022;13:950914 pubmed publisher |
Shivalingappa P, Singh D, Sharma V, Arora V, Shiras A, Bapat S. RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation. Stem Cell Rev Rep. 2022;:1-16 pubmed publisher |
Shi D, Savani M, Levitt M, Wang A, Endress J, Bird C, et al. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell. 2022;40:939-956.e16 pubmed publisher |
Zhou H, Guan Q, Hou X, Liu L, Zhou L, Li W, et al. Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells. Int J Biol Sci. 2022;18:4869-4883 pubmed publisher |
Bagchi A, Devaraju N, Chambayil K, Rajendiran V, Venkatesan V, Sayed N, et al. Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications. Sci Rep. 2022;12:14033 pubmed publisher |
Gros M, Segura E, Rookhuizen D, Baudon B, Heurtebise Chr xe9 tien S, Burgdorf N, et al. Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation. Cell Rep. 2022;40:111205 pubmed publisher |
Khateb M, Perovanovic J, Ko K, Jiang K, Feng X, Acevedo Luna N, et al. Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution. Cell Rep. 2022;40:111219 pubmed publisher |
White T, Stanfield B, Bonavita C, Rudd J, Cardin R. Development of a mouse salivary gland-derived mesenchymal cell line for immunological studies of murine cytomegalovirus. PLoS ONE. 2022;17:e0265479 pubmed publisher |
Azadbakht M, Sayadmanesh A, Nazer N, Ahmadi A, Hemmati S, Mohammadzade H, et al. CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells. Bioimpacts. 2022;12:337-347 pubmed publisher |
Bo Z, Huang S, Li L, Chen L, Chen P, Luo X, et al. EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes. BMC Cardiovasc Disord. 2022;22:373 pubmed publisher |
Parker E, Anderson C, Zeller M, Tibi A, Havens J, Laroche G, et al. Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions. Nat Commun. 2022;13:4784 pubmed publisher |
Yang L, Lin K, Zhu L, Wang H, Teng S, Huang L, et al. Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress. Commun Biol. 2022;5:822 pubmed publisher |
Miljkovic J, Burger N, Gawel J, Mulvey J, Norman A, Nishimura T, et al. Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biol. 2022;55:102429 pubmed publisher |
Sang X, Zhang Y, Fang F, Gao L, Tao Y, Li X, et al. BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia. J Immunol Res. 2022;2022:7912484 pubmed publisher |
Ngo W, Wu J, Lin Z, Zhang Y, Bussin B, Granda Farias A, et al. Identifying cell receptors for the nanoparticle protein corona using genome screens. Nat Chem Biol. 2022;18:1023-1031 pubmed publisher |
Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, et al. Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases. Cell. 2022;185:3232-3247.e18 pubmed publisher |
Rao D, Yu C, Wang T, Sheng J, Lv E, Liang H, et al. Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker. Int Immunopharmacol. 2022;111:109091 pubmed publisher |
Castrogiovanni C, Inchingolo A, Harrison J, Dudka D, Sen O, Burroughs N, et al. Evidence for a HURP/EB free mixed-nucleotide zone in kinetochore-microtubules. Nat Commun. 2022;13:4704 pubmed publisher |
Pontel L, Bueno Costa A, Morellato A, Carvalho Santos J, Rou xe9 G, Esteller M. Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing. Redox Biol. 2022;55:102408 pubmed publisher |
Liu S, Qiao X, Wu S, Gai Y, Su Y, Edwards H, et al. c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia. Apoptosis. 2022;27:913-928 pubmed publisher |
Migliavacca J, Z xfc llig B, Capdeville C, Grotzer M, Baumgartner M. Cooperation of Striatin 3 and MAP4K4 promotes growth and tissue invasion. Commun Biol. 2022;5:795 pubmed publisher |
Kawashima A, Kiriya M, En J, Tanigawa K, Nakamura Y, Fujiwara Y, et al. Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells. PLoS Negl Trop Dis. 2022;16:e0010672 pubmed publisher |
Torrens Mas M, Perell xf3 Reus C, Trias Ferrer N, Ibarg xfc en Gonz xe1 lez L, Cresp xed C, Galmes Panades A, et al. GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibility. Front Cell Infect Microbiol. 2022;12:942951 pubmed publisher |
Avsar T, Kose T, Oksal M, Turan G, Kilic T. IDH1 mutation activates mTOR signaling pathway, promotes cell proliferation and invasion in glioma cells. Mol Biol Rep. 2022;49:9241-9249 pubmed publisher |
Karlowitz R, Stanifer M, Roedig J, Andrieux G, Bojkova D, Bechtel M, et al. USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Cell Death Dis. 2022;13:684 pubmed publisher |
Xiao Q, Zhang X, Tu L, Cao J, Hinrichs C, Su X. Size-dependent activation of CAR-T cells. Sci Immunol. 2022;7:eabl3995 pubmed publisher |
Cao L, Morgun E, Genardi S, Visvabharathy L, Cui Y, Huang H, et al. METTL14-dependent m6A modification controls iNKT cell development and function. Cell Rep. 2022;40:111156 pubmed publisher |
Dabla A, Liang Y, Rajabalee N, Irwin C, Moonen C, Willis J, et al. TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages. MBio. 2022;13:e0145622 pubmed publisher |
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022;608:778-783 pubmed publisher |
Brown M, Abdollahi B, Wilkins O, Lu H, Chakraborty P, Ognjenovic N, et al. Phenotypic heterogeneity driven by plasticity of the intermediate EMT state governs disease progression and metastasis in breast cancer. Sci Adv. 2022;8:eabj8002 pubmed publisher |
Chen G, Yu B, Tan S, Tan J, Jia X, Zhang Q, et al. GIGYF1 disruption associates with autism and impaired IGF-1R signaling. J Clin Invest. 2022;132: pubmed publisher |
S xe1 nchez S xe1 nchez J, Vicente Garc xed a C, Ca xf1 ada Garc xed a D, Mart xed n Zanca D, Ar xe9 valo J. ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion. Pain. 2022;: pubmed publisher |
Hsu Y, Yin Y, Tsai K, Jian C, Liang Z, Hsu C, et al. TGFBR3 supports anoikis through suppressing ATF4 signaling. J Cell Sci. 2022;135: pubmed publisher |
Ning N, Zhang S, Wu Q, Li X, Kuang D, Duan Y, et al. Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression. Theranostics. 2022;12:5537-5550 pubmed publisher |
Na Z, Dai X, Zheng S, Bryant C, Loh K, Su H, et al. Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Mol Cell. 2022;82:2900-2911.e7 pubmed publisher |
LeBlanc E, Colpitts C. The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor. Sci Rep. 2022;12:12899 pubmed publisher |
Perelroizen R, Philosof B, Budick Harmelin N, Chernobylsky T, Ron A, Katzir R, et al. Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity. Brain. 2022;145:3288-3307 pubmed publisher |
Dibble C, Barritt S, Perry G, Lien E, Geck R, DuBois Coyne S, et al. PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature. 2022;608:192-198 pubmed publisher |
Bell E, Shah P, Zuela Sopilniak N, Kim D, Varlet A, Morival J, et al. Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer. Oncogene. 2022;41:4211-4230 pubmed publisher |
Roelle S, Shukla N, Pham A, Bruchez A, Matreyek K. Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains. PLoS Biol. 2022;20:e3001738 pubmed publisher |
Alewine G, Knight J, Ghantae A, Mamrega C, Attiah B, Coover R, et al. Silver Nanoparticles Selectively Treat Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors in a Neurofibromin-Dependent Manner. J Pers Med. 2022;12: pubmed publisher |
Nam D, Park M, Lee H, Bae S, Gerovska D, Ara xfa zo Bravo M, et al. Induced Endothelial Cell-Integrated Liver Assembloids Promote Hepatic Maturation and Therapeutic Effect on Cholestatic Liver Fibrosis. Cells. 2022;11: pubmed publisher |
de Mendoza A, Nguyen T, Ford E, Poppe D, Buckberry S, Pflueger J, et al. Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability. Genome Biol. 2022;23:163 pubmed publisher |
Amen A, Loughran R, Huang C, Lew R, Ravi A, Guan Y, et al. Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. Cell Rep Methods. 2022;2:100239 pubmed publisher |
Li J, Zhang F, Bian W, Chen Y, Liu J, Liu Z, et al. cGAS inhibition alleviates Alu RNA-induced immune responses and cytotoxicity in retinal pigmented epithelium. Cell Biosci. 2022;12:116 pubmed publisher |
Krei xdf M, Oberlis J, Seuter S, Bischoff Kont I, S xfc r xfc n D, Thomas D, et al. Human 5-lipoxygenase regulates transcription by association to euchromatin. Biochem Pharmacol. 2022;203:115187 pubmed publisher |
Gusho E, Laimins L. Human papillomaviruses sensitize cells to DNA damage induced apoptosis by targeting the innate immune sensor cGAS. PLoS Pathog. 2022;18:e1010725 pubmed publisher |
Acklin S, Sadhukhan R, Du W, Patra M, Cholia R, Xia F. Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation. Neurooncol Adv. 2022;4:vdac101 pubmed publisher |
Chen Z, Hao W, Tang J, Gao W, Xu H. CSTF2 Promotes Hepatocarcinogenesis and Hepatocellular Carcinoma Progression via Aerobic Glycolysis. Front Oncol. 2022;12:897804 pubmed publisher |
Kelly M, Wisniewska K, Regner M, Lewis M, Perreault A, Davis E, et al. A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. Nat Commun. 2022;13:4247 pubmed publisher |
Feng D, Gao P, Henley N, Dubuissez M, Chen N, Laurin L, et al. SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin. Cell Death Dis. 2022;13:639 pubmed publisher |
Jin Y, Anbarchian T, Wu P, Sarkar A, Fish M, Peng W, et al. Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade. Proc Natl Acad Sci U S A. 2022;119:e2203849119 pubmed publisher |
Jana A, Tran A, Gill A, Kiepas A, Kapania R, Konstantopoulos K, et al. Sculpting Rupture-Free Nuclear Shapes in Fibrous Environments. Adv Sci (Weinh). 2022;9:e2203011 pubmed publisher |
Krokowski D, Jobava R, Szkop K, Chen C, Fu X, Venus S, et al. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Cell Rep. 2022;40:111092 pubmed publisher |
Janssen M, Schmidt C, Bruch P, Blank M, Rohde C, Waclawiczek A, et al. Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1. Blood. 2022;140:2594-2610 pubmed publisher |
Goob G, Adrian J, Cossu C, Hauck C. Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ. J Biol Chem. 2022;298:102269 pubmed publisher |
Zou Y, Zheng Q, Jiang B, Liu Y, Xu Y, Ma L, et al. Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1. Cell Death Dis. 2022;13:618 pubmed publisher |
Ferguson I, Pati xf1 o Escobar B, Tuomivaara S, Lin Y, Nix M, Leung K, et al. The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nat Commun. 2022;13:4121 pubmed publisher |
Darp R, Vittoria M, Ganem N, Ceol C. Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nat Commun. 2022;13:4109 pubmed publisher |
Ma L, Zou R, Shi W, Zhou N, Chen S, Zhou H, et al. SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways. Theranostics. 2022;12:5034-5050 pubmed publisher |
Lu Y, Mu Y, Chen J, Guan X, Guo L, Wu C. CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1. Theranostics. 2022;12:5051-5068 pubmed publisher |
Cho Y, Yoon Y, Im H, Son Y, Kim M, Saha A, et al. Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. Nat Commun. 2022;13:4084 pubmed publisher |
Omar M, Byrne D, Jones K, Lakey T, Collins K, Lee K, et al. Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep. 2022;40:111073 pubmed publisher |
Schmieder S, Tatituri R, Anderson M, Kelly K, Lencer W. Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking. Cell Rep. 2022;40:111063 pubmed publisher |
Staels F, Lorenzetti F, De Keukeleere K, Willemsen M, Gerbaux M, Neumann J, et al. A Novel Homozygous Stop Mutation in IL23R Causes Mendelian Susceptibility to Mycobacterial Disease. J Clin Immunol. 2022;42:1638-1652 pubmed publisher |
Fauser J, Huyot V, Matsche J, Szynal B, Alexeev Y, Kota P, et al. Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity. J Cell Biol. 2022;221: pubmed publisher |
Zhukovsky N, Silvano M, Filloux T, Gonzalez S, Krause K. Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition. Int J Mol Sci. 2022;23: pubmed publisher |
Le Nabec A, Blotas C, Briset A, Collobert M, Ferec C, Moisan S. 3D Chromatin Organization Involving MEIS1 Factor in the cis-Regulatory Landscape of GJB2. Int J Mol Sci. 2022;23: pubmed publisher |
Kim P, Park J, Lee D, Mizuno S, Shinohara M, Hong C, et al. Mast4 determines the cell fate of MSCs for bone and cartilage development. Nat Commun. 2022;13:3960 pubmed publisher |
Sayed S, Sidorova O, Hennig A, Augsburg M, Cortes Vesga C, Abohawya M, et al. Efficient correction of oncogenic KRAS and TP53 mutations through CRISPR base editing. Cancer Res. 2022;: pubmed publisher |
Ananthapadmanabhan V, Frost T, Soroko K, Knott A, Magliozzi B, Gokhale P, et al. Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma. JCI Insight. 2022;7: pubmed publisher |
Ye F, Alvarez Carbonell D, Nguyen K, Leskov K, Garcia Mesa Y, Sreeram S, et al. Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells. PLoS Pathog. 2022;18:e1010110 pubmed publisher |
Phan Q, Solis N, Lin J, Swidergall M, Singh S, Liu H, et al. Serum bridging molecules drive candidal invasion of human but not mouse endothelial cells. PLoS Pathog. 2022;18:e1010681 pubmed publisher |
del Rio M, Perez Simon J, Rodriguez Barbosa J. Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance. Front Immunol. 2022;13:887348 pubmed publisher |
Schmitt D, Curtis S, Lyons A, Zhang J, Chen M, He C, et al. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nat Commun. 2022;13:3856 pubmed publisher |
Patel A, Warda S, Mååg J, Misra R, Miranda Roman M, Pachai M, et al. PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry. Cancer Discov. 2022;: pubmed publisher |
Long K, Li X, Su D, Zeng S, Li H, Zhang Y, et al. Exploring high-resolution chromatin interaction changes and functional enhancers of myogenic marker genes during myogenic differentiation. J Biol Chem. 2022;:102149 pubmed publisher |
Gandhi A, Yu J, Gupta A, Guo T, Iyengar P, Infante R. Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia. Front Oncol. 2022;12:841758 pubmed publisher |
Forsythe S, Sivakumar H, Erali R, Wajih N, Li W, Shen P, et al. Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications. Ann Surg Oncol. 2022;29:7354-7367 pubmed publisher |
Chavan S, Khuperkar D, Lonare A, Panigrahi S, Bellare J, Rapole S, et al. RanGTPase links nucleo-cytoplasmic transport to the recruitment of cargoes into small extracellular vesicles. Cell Mol Life Sci. 2022;79:392 pubmed publisher |
Zhou Z, Ren Y, Yang J, Liu M, Shi X, Luo W, et al. Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer. Gastroenterology. 2022;163:1281-1293.e1 pubmed publisher |
Xiang Q, Yang Z, Nicholas J. STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling. PLoS Pathog. 2022;18:e1010676 pubmed publisher |
Quan M, Oh Y, Cho S, Kim J, Moon H. Polo-Like Kinase 1 Regulates Chromosomal Instability and Paclitaxel Resistance in Breast Cancer Cells. J Breast Cancer. 2022;25:178-192 pubmed publisher |
Liu T, Tang J, Li X, Lin Y, Yang Y, Ma K, et al. The Key Network of mRNAs and miRNAs Regulated by HIF1A in Hypoxic Hepatocellular Carcinoma Cells. Front Genet. 2022;13:857507 pubmed publisher |
Santana Codina N, Del Rey M, Kapner K, Zhang H, Gikandi A, Malcolm C, et al. NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins. Cancer Discov. 2022;12:2180-2197 pubmed publisher |
Hoffman H, Aguilar R, Clark A, Groves N, Pezeshkian N, Bruns M, et al. Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14+ Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines. J Virol. 2022;:e0076722 pubmed publisher |
Hutcheson R, Hayes M, Sugden B. Optimal LentiCRISPR-Based System for Sequential CRISPR/Cas9 Screens. ACS Synth Biol. 2022;: pubmed publisher |
Sellar R, Sperling A, Słabicki M, Gasser J, McConkey M, Donovan K, et al. Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells. J Clin Invest. 2022;: pubmed publisher |
Dai Z, Guo W, Yu D, Zhu X, Sun S, Huang H, et al. SECISBP2L-mediated selenoprotein synthesis is essential for autonomous regulation of oligodendrocyte differentiation. J Neurosci. 2022;: pubmed publisher |
Im N, Guillaumet Adkins A, Wal M, Rogers A, Frede J, Havig C, et al. Regulatory programs of B-cell activation and germinal center reaction allow B-ALL escape from CD19 CAR T-cell therapy. Cancer Immunol Res. 2022;: pubmed publisher |
Höfle J, Trenkner T, Kleist N, Schwane V, Vollmers S, Barcelona B, et al. Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells. EMBO Rep. 2022;:e54133 pubmed publisher |
Fagundes R, Bourgonje A, Hu S, Barbieri R, Jansen B, Sinnema N, et al. HIF1α-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease. Front Physiol. 2022;13:889091 pubmed publisher |
Zhu J, Ma X, Jing Y, Zhang G, Zhang D, Mao Z, et al. P4HB UFMylation regulates mitochondrial function and oxidative stress. Free Radic Biol Med. 2022;188:277-286 pubmed publisher |
Khan T, Ginsburg D, Emmer B. The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes. J Lipid Res. 2022;:100248 pubmed publisher |
Zhang P, Amarasinghe H, Whalley J, Tay C, Fang H, Migliorini G, et al. Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance. Genome Biol. 2022;23:136 pubmed publisher |
Kelenis D, Rodarte K, Kollipara R, Pozo K, Pal Choudhuri S, Spainhower K, et al. Inhibition of karyopherin β1-mediated nuclear import disrupts oncogenic lineage- defining transcription factor activity in small cell lung cancer. Cancer Res. 2022;: pubmed publisher |
Yarovaya O, Shcherbakov D, Borisevich S, Sokolova A, Gureev M, Khamitov E, et al. Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses. Viruses. 2022;14: pubmed publisher |
Sayed S, Sürün D, Mircetic J, Sidorova O, Buchholz F. Using CRISPR-Cas9 to Dissect Cancer Mutations in Cell Lines. Methods Mol Biol. 2022;2508:235-260 pubmed publisher |
Zhang Z, Yi J, Xie B, Chen J, Zhang X, Wang L, et al. Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells. Curr Issues Mol Biol. 2022;44:2759-2771 pubmed publisher |
Ma Y, Kang B, Li S, Xie G, Bi J, Li F, et al. CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma. Mol Ther. 2022;30:3341-3357 pubmed publisher |
Geng C, Chen J, Song T, Jung J, Long M, Song M, et al. Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling. Cell Chem Biol. 2022;: pubmed publisher |
Hou R, Yu Y, Sluter M, Li L, Hao J, Fang J, et al. Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma. Cell Rep. 2022;39:111000 pubmed publisher |
Liu Z, Nan Y, Luo Q, Wu X, Liu S, Zhao P, et al. DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma. Cancer Res. 2022;: pubmed publisher |
Fang F, Cao W, Mu Y, Okuyama H, Li L, Qiu J, et al. IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression. JCI Insight. 2022;7: pubmed publisher |
Liu H, Lin J, Zhou W, Moses R, Dai Z, Kossenkov A, et al. KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer. Cancer Immunol Res. 2022;:OF1-OF11 pubmed publisher |
Ong Y, Andrade J, Armbruster M, Shi C, Castro M, Costa A, et al. A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth. Nat Metab. 2022;4:672-682 pubmed publisher |
Akkoç Y, Dalci K, Karakas H, Erbil Bilir S, Yalav O, Sakman G, et al. Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis. Autophagy. 2022;:1-18 pubmed publisher |
Gu D, Dong K, Jiang A, Jiang S, Fu Z, Bao Y, et al. PBRM1 Deficiency Sensitizes Renal Cancer Cells to DNMT Inhibitor 5-Fluoro-2'-Deoxycytidine. Front Oncol. 2022;12:870229 pubmed publisher |
Singh N, Benoit M, Zhou J, Das B, Davila Velderrain J, Kellis M, et al. BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1. Sci Adv. 2022;8:eabo1286 pubmed publisher |
Potolitsyna E, Hazell Pickering S, Germier T, Collas P, Briand N. Long non-coding RNA HOTAIR regulates cytoskeleton remodeling and lipid storage capacity during adipogenesis. Sci Rep. 2022;12:10157 pubmed publisher |
Lee J, Sung K, Joo S, Jeong J, Kim S, Lee H. Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis. Nat Commun. 2022;13:3396 pubmed publisher |
Ha T, Diprima M, Koparde V, Jailwala P, Ohnuki H, Feng J, et al. Antisense transcription from lentiviral gene targeting linked to an integrated stress response in colorectal cancer cells. Mol Ther Nucleic Acids. 2022;28:877-891 pubmed publisher |
Guendisch U, Loos B, Cheng P, Dummer R, Levesque M, Varum S, et al. Loss of YY1, a Regulator of Metabolism in Melanoma, Drives Melanoma Cell Invasiveness and Metastasis Formation. Front Cell Dev Biol. 2022;10:916033 pubmed publisher |
Hua R, Gu S, Jiang J. Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation. Front Cell Dev Biol. 2022;10:892229 pubmed publisher |
Guo Z, Liu X, Chen M. Defining pervasive transcription units using chromatin RNA-sequencing data. STAR Protoc. 2022;3:101442 pubmed publisher |
Li N, Du H, Mao L, Xu G, Zhang M, Fan Y, et al. Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles. J Nanobiotechnology. 2022;20:270 pubmed publisher |
Xu B, Zhang C, Jiang A, Zhang X, Liang F, Wang X, et al. Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation. J Biol Chem. 2022;:102115 pubmed publisher |
Tomofuji K, Fukumitsu K, Kondo J, Horie H, Makino K, Wakama S, et al. Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts. Biomaterials. 2022;287:121614 pubmed publisher |
Yang H, Ting X, Geng Y, Xie Y, Nierenberg J, Huo Y, et al. The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. Sci Adv. 2022;8:eabn3509 pubmed publisher |
Malacarne P, Bezzenberger J, Lopez M, Warwick T, Müller N, Brandes R, et al. Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone. Int J Mol Sci. 2022;23: pubmed publisher |
Gallardo A, Molina A, Asenjo H, López Onieva L, Martorell Marugan J, Espinosa Martinez M, et al. EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization. Oncogene. 2022;41:3611-3624 pubmed publisher |
Lu Z, Ni K, Wang Y, Zhou Y, Li Y, Yan J, et al. An in-library ligation strategy and its application in CRISPR/Cas9 screening of high-order gRNA combinations. Nucleic Acids Res. 2022;: pubmed publisher |
Lindqvist B, Jütte B, Love L, Assi W, Roux J, Sonnerborg A, et al. T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin. PLoS Pathog. 2022;18:e1010555 pubmed publisher |
Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, et al. Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model. Gastric Cancer. 2022;: pubmed publisher |
Yang L, Chen S, Xia J, Zhou Y, Peng L, Fan H, et al. Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection. Cell Biosci. 2022;12:81 pubmed publisher |
Cao L, Luo Y, Guo X, Liu S, Li S, Li J, et al. SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs. PLoS Pathog. 2022;18:e1010599 pubmed publisher |
Li X, Michels B, Tosun O, Jung J, Kappes J, Ibing S, et al. 5'isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1. J Exp Clin Cancer Res. 2022;41:190 pubmed publisher |
Liu X, Mei W, Padmanaban V, Alwaseem H, Molina H, Passarelli M, et al. A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. Mol Cell. 2022;: pubmed publisher |
Kong X, Kapustka A, Sullivan B, Schwarz G, Leckband D. Extracellular matrix regulates force transduction at VE-cadherin junctions. Mol Biol Cell. 2022;:mbcE22030075 pubmed publisher |
Dhupar R, Jones K, Powers A, Eisenberg S, Ding K, Chen F, et al. Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer. Front Immunol. 2022;13:830169 pubmed publisher |
Gui R, Zheng H, Ma L, Liu R, Lin X, Ke X, et al. Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway. MBio. 2022;13:e0061522 pubmed publisher |
Xiong Y, Li Y, Cui X, Zhang L, Yang X, Liu H. ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. Cell Mol Immunol. 2022;: pubmed publisher |
Yao Q, Xie Y, Xu D, Qu Z, Wu J, Zhou Y, et al. Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3. Cell Mol Immunol. 2022;19:883-897 pubmed publisher |
Sun Y, Yang Y, Hu Y, Ouyang L, Sun Z, Yin X, et al. Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death. Redox Biol. 2022;53:102334 pubmed publisher |
Fonnesu R, Thunuguntla V, Veeramachaneni G, Bondili J, La Rocca V, Filipponi C, et al. Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor. Viruses. 2022;14: pubmed publisher |
Lu Y, Wang J, Tang F, Pratap U, Sareddy G, Dhandapani K, et al. Regulation and Role of Neuron-Derived Hemoglobin in the Mouse Hippocampus. Int J Mol Sci. 2022;23: pubmed publisher |
Kim K, Shin D, Lee G, Bae H. Loss of SP-A in the Lung Exacerbates Pulmonary Fibrosis. Int J Mol Sci. 2022;23: pubmed publisher |
Zhu X, Ma J, Lu M, Liu Z, Sun Y, Chen H. The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor. Genes (Basel). 2022;13: pubmed publisher |
Abuhamad A, Mohamad Zamberi N, Sheen L, Naes S, Mohd Yusuf S, Ahmad Tajudin A, et al. Reverting TP53 Mutation in Breast Cancer Cells: Prime Editing Workflow and Technical Considerations. Cells. 2022;11: pubmed publisher |
Lastra D, Escoll M, Cuadrado A. Transcription Factor NRF2 Participates in Cell Cycle Progression at the Level of G1/S and Mitotic Checkpoints. Antioxidants (Basel). 2022;11: pubmed publisher |
Gangopadhyay A, Devi S, Tenguria S, Carrière J, Nguyen H, Jäger E, et al. NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. Nat Immunol. 2022;23:892-903 pubmed publisher |
Poświata A, Kozik K, Miaczynska M, Zdżalik Bielecka D. Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation. Cell Mol Life Sci. 2022;79:316 pubmed publisher |
Arnan C, Ullrich S, Pulido Quetglas C, Nurtdinov R, Esteban A, Blanco Fernandez J, et al. Paired guide RNA CRISPR-Cas9 screening for protein-coding genes and lncRNAs involved in transdifferentiation of human B-cells to macrophages. BMC Genomics. 2022;23:402 pubmed publisher |
Michmerhuizen A, Lerner L, Ward C, Pesch A, Zhang A, Schwartz R, et al. Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer. Br J Cancer. 2022;: pubmed publisher |
Li W, Chen J, Sun C, Sparks R, Pantano L, Rahman R, et al. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. elife. 2022;11: pubmed publisher |
Thege F, Cardle I, Gruber C, Siemann M, Cong S, Wittmann K, et al. Acquired chemoresistance drives spatial heterogeneity, chemoprotection and collective migration in pancreatic tumor spheroids. PLoS ONE. 2022;17:e0267882 pubmed publisher |
Park S, Uchida T, Tilson S, Hu Z, Ma C, Leek M, et al. A dual conditional CRISPR-Cas9 system to activate gene editing and reduce off-target effects in human stem cells. Mol Ther Nucleic Acids. 2022;28:656-669 pubmed publisher |
Sorci M, Fink T, Sharma V, Singh S, Chen R, Arduini B, et al. Virucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings. ACS Appl Mater Interfaces. 2022;14:25135-25146 pubmed publisher |
Pferdehirt L, Damato A, Dudek M, Meng Q, Herzog E, Guilak F. Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1-induced inflammation. Sci Adv. 2022;8:eabj8892 pubmed publisher |
Xu W, Liu C, Deng B, Lin P, Sun Z, Liu A, et al. TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation. Genome Res. 2022;32:1026-1041 pubmed publisher |
Jin X, Li L, Peng Q, Gan C, Gao L, He S, et al. Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2. iScience. 2022;25:104349 pubmed publisher |
Serna R, Ramrakhiani A, Hernández J, Chen C, Nakagawa C, Machida T, et al. c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity. iScience. 2022;25:104325 pubmed publisher |
Zhu D, Han F, Sun L, Agnihotri S, Hu Y, Bueler H. Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission. Front Oncol. 2022;12:893396 pubmed publisher |
Agrawal Y, Sharma T, Islam S, Nadkarni K, Santra M. F-box protein FBXO41 suppresses breast cancer growth by inducing autophagic cell death through facilitating proteasomal degradation of oncogene SKP2. Int J Biochem Cell Biol. 2022;147:106228 pubmed publisher |
Vanhulle E, Stroobants J, Provinciael B, Camps A, Noppen S, Maes P, et al. SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening. Antiviral Res. 2022;203:105342 pubmed publisher |
Breyne K, Ughetto S, Rufino Ramos D, Mahjoum S, Grandell E, de Almeida L, et al. Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins. Commun Biol. 2022;5:485 pubmed publisher |
Jairak W, Chamsai E, Udom K, Charoenkul K, Chaiyawong S, Techakriengkrai N, et al. SARS-CoV-2 delta variant infection in domestic dogs and cats, Thailand. Sci Rep. 2022;12:8403 pubmed publisher |
Yuan Q, Gao X. Multiplex base- and prime-editing with drive-and-process CRISPR arrays. Nat Commun. 2022;13:2771 pubmed publisher |
Dong X, Zhang X, Liu P, Tian Y, Li L, Gong P. Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 via PPPY Motif. Front Oncol. 2022;12:896412 pubmed publisher |
Demirbag Sarikaya S, Akkoç Y, Turgut S, Erbil Bilir S, Kocaturk N, Dengjel J, et al. A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Sci Rep. 2022;12:8134 pubmed publisher |
Soflaee M, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, et al. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun. 2022;13:2698 pubmed publisher |
Wu X, He X, Ipsaro J, Huang Y, Preall J, Ng D, et al. OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature. 2022;607:169-175 pubmed publisher |
Kiik H, Ramanayake S, Miura M, Tanaka Y, Melamed A, Bangham C. Time-course of host cell transcription during the HTLV-1 transcriptional burst. PLoS Pathog. 2022;18:e1010387 pubmed publisher |
Duclaux Loras R, Lebreton C, Berthelet J, Charbit Henrion F, Nicolle O, Revenu de Courtils C, et al. UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. J Clin Invest. 2022;132: pubmed publisher |
Yu F, Pan T, Huang F, Ying R, Liu J, Fan H, et al. Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin L. Front Microbiol. 2022;13:884034 pubmed publisher |
Filipponi D, Pagnuzzi Boncompagni M, Pages G. Inhibiting ALK2/ALK3 Signaling to Differentiate and Chemo-Sensitize Medulloblastoma. Cancers (Basel). 2022;14: pubmed publisher |
Pellegrino R, Castoldi M, Ticconi F, Skawran B, Budczies J, Rose F, et al. LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma. Cells. 2022;11: pubmed publisher |
Garreta E, Prado P, Stanifer M, Monteil V, Marco A, Ullate Agote A, et al. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. Cell Metab. 2022;34:857-873.e9 pubmed publisher |
Lee K, Lin C, Servetto A, Bae J, Kandagatla V, Ye D, et al. Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer. Cancer Immunol Res. 2022;10:829-843 pubmed publisher |
Hason M, Jovicic J, Vonkova I, Bojic M, Simon Vermot T, White R, et al. Bioluminescent Zebrafish Transplantation Model for Drug Discovery. Front Pharmacol. 2022;13:893655 pubmed publisher |
Khodeer S, Klungland A, Dahl J. ALKBH5 regulates somatic cell reprogramming in a phase-specific manner. J Cell Sci. 2022;135: pubmed publisher |
Xie Y, Wang Y, Xu Z, Lu Y, Song D, Gao L, et al. Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma. J Biomed Sci. 2022;29:32 pubmed publisher |
Kumar A, Lyu Y, Yanagihashi Y, Chantarasrivong C, Majerciak V, Salemi M, et al. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Cell Rep. 2022;39:110788 pubmed publisher |
Wang Y, Liu B, Lu H, Liu J, Romanienko P, Montelione G, et al. SETD4-mediated KU70 methylation suppresses apoptosis. Cell Rep. 2022;39:110794 pubmed publisher |
Jacquemin G, Wurmser A, Huyghe M, Sun W, Homayed Z, Merle C, et al. Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme. elife. 2022;11: pubmed publisher |
Dong C, Fu S, Karvas R, Chew B, Fischer L, Xing X, et al. A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells. Nat Commun. 2022;13:2548 pubmed publisher |
Kuchler O, Gerlach J, Vomhof T, Hettich J, Steinmetz J, Gebhardt J, et al. Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation. Open Biol. 2022;12:210383 pubmed publisher |
Drosos Y, Myers J, Xu B, Mathias K, Beane E, Radko Juettner S, et al. NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. Mol Cell. 2022;82:2472-2489.e8 pubmed publisher |
Windsor I, Tong P, Lavidor O, Sanjari Moghaddam A, McKay L, Gautam A, et al. Antibodies induced by ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1. Sci Immunol. 2022;:eabo3425 pubmed publisher |
Cheng K, Mohamed E, Syafruddin S, Ibrahim Z. Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis. J Cell Commun Signal. 2022;: pubmed publisher |
Aubrey B, Cutler J, Bourgeois W, Donovan K, Gu S, Hatton C, et al. IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Nat Cancer. 2022;3:595-613 pubmed publisher |
Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, et al. Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. Nat Metab. 2022;4:575-588 pubmed publisher |
Pereira P, Mandleywala K, Monette S, Lumish M, Tully K, Panikar S, et al. Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer. Nat Commun. 2022;13:2526 pubmed publisher |
Pogacar Z, Groot K, Jochems F, Dos Santos Dias M, Mulero S xe1 nchez A, Morris B, et al. Genetic and compound screens uncover factors modulating cancer cell response to indisulam. Life Sci Alliance. 2022;5: pubmed publisher |
Wu T, Rabi S, Michaud W, Becerra D, Gilpin S, Mino Kenudson M, et al. Protease inhibitor Camostat Mesyalte blocks wild type SARS-CoV-2 and D614G viral entry in human engineered miniature lungs. Biomaterials. 2022;285:121509 pubmed publisher |
Gubat J, Selvaraju K, Sjöstrand L, Kumar Singh D, Turkina M, Schmierer B, et al. Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action. Front Oncol. 2022;12:852980 pubmed publisher |
Sung E, Ko M, Won J, Jo Y, Park E, Kim H, et al. LAG-3xPD-L1 bispecific antibody potentiates antitumor responses of T cells through dendritic cell activation. Mol Ther. 2022;: pubmed publisher |
Gao W, Wang Y, Yu S, Wang Z, Ma T, Chan A, et al. Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells. Stem Cell Res Ther. 2022;13:188 pubmed publisher |
Reticker Flynn N, Zhang W, Belk J, Basto P, Escalante N, Pilarowski G, et al. Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell. 2022;185:1924-1942.e23 pubmed publisher |
Singh T, Beatty A, Peterson J. The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells. Cell Death Discov. 2022;8:253 pubmed publisher |
Davidson R, Weaver S, Casey N, Kanojia S, Hogarth E, Schneider Aguirre R, et al. The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function. J Mol Endocrinol. 2022;69:329-341 pubmed publisher |
Kalejaiye T, Bhattacharya R, Burt M, Travieso T, Okafor A, Mou X, et al. SARS-CoV-2 Employ BSG/CD147 and ACE2 Receptors to Directly Infect Human Induced Pluripotent Stem Cell-Derived Kidney Podocytes. Front Cell Dev Biol. 2022;10:855340 pubmed publisher |
Li R, Klingbeil O, Monducci D, Young M, Rodríguez D, Bayyat Z, et al. Comparative optimization of combinatorial CRISPR screens. Nat Commun. 2022;13:2469 pubmed publisher |
Shi X, Reinstadler B, Shah H, To T, Byrne K, Summer L, et al. Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nat Commun. 2022;13:2483 pubmed publisher |
Mac Kain A, Maarifi G, Aicher S, Arhel N, Baidaliuk A, Munier S, et al. Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Nat Commun. 2022;13:2442 pubmed publisher |
Bohnsack J, Zhang H, Wandling G, He D, Kyzar E, Lasek A, et al. Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Sci Adv. 2022;8:eabn2748 pubmed publisher |
Lee J, Xu Y, Saidi L, Xu M, ZINSMAIER K, Ye Y. Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation. Autophagy. 2022;:1-20 pubmed publisher |
Liu Z, Chen T, Zhang S, Yang T, Gong Y, Deng H, et al. Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals. elife. 2022;11: pubmed publisher |
Zhang Y, Trang V, Palmer D, Kishton R, Gong L, Huang J, et al. A T cell resilience model associated with response to immunotherapy in multiple tumor types. Nat Med. 2022;: pubmed publisher |
Papes F, Camargo A, de Souza J, Carvalho V, Szeto R, LaMontagne E, et al. Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Nat Commun. 2022;13:2387 pubmed publisher |
Hemming M, Benson M, Loycano M, Anderson J, Andersen J, Taddei M, et al. MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. Cancer Discov. 2022;12:1804-1823 pubmed publisher |
Wang H, Wang P, Zhu B. Mechanism of Erastin-Induced Ferroptosis in MDA-MB-231 Human Breast Cancer Cells: Evidence for a Critical Role of Protein Disulfide Isomerase. Mol Cell Biol. 2022;42:e0052221 pubmed publisher |
Wu L, Liu L, Xu B, Huang D, Chen X. In vitro and in vivo assay of the ER lipid scramblase TMEM41B. STAR Protoc. 2022;3:101333 pubmed publisher |
Sun C, Wu G, Zhang Z, Cao R, Cui S. Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve Injury via the STING-IFN-I Pathway. Front Mol Neurosci. 2022;15:859166 pubmed publisher |
Kim D, Ahn J, Suh Y, Ziouzenkova O, Lee J, Lee K. Retinol Binding Protein 7 Promotes Adipogenesis in vitro and Regulates Expression of Genes Involved in Retinol Metabolism. Front Cell Dev Biol. 2022;10:876031 pubmed publisher |
Palacios Prado N, Soto P, L xf3 pez X, Choi E, Márquez Miranda V, Rojas M, et al. Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Proc Natl Acad Sci U S A. 2022;119:e2202104119 pubmed publisher |
Ferrandiz N, Downie L, Starling G, Royle S. Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes. J Cell Biol. 2022;221: pubmed publisher |
Alborzinia H, Flórez A, Kreth S, Brückner L, Yildiz U, Gartlgruber M, et al. MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. Nat Cancer. 2022;3:471-485 pubmed publisher |
Liu W, Gajendran B, Sample K, Wang C, Hu A, Chen B, et al. A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer. Cancer Gene Ther. 2022;: pubmed publisher |
Nouruzi S, Ganguli D, Tabrizian N, Kobelev M, Sivak O, Namekawa T, et al. ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer. Nat Commun. 2022;13:2282 pubmed publisher |
Tse L, Meganck R, Araba K, Yount B, Shaffer K, Hou Y, et al. Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection. Proc Natl Acad Sci U S A. 2022;119:e2118126119 pubmed publisher |
Challa S, Ryu K, Whitaker A, Abshier J, Camacho C, Kraus W. Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo. elife. 2022;11: pubmed publisher |
Xu X, Shobuike T, Shiraki M, Kamohara A, Hirata H, Murayama M, et al. Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68. Lab Invest. 2022;: pubmed publisher |
Yu P, Guo J, Li J, Shi X, Xu N, Jiang Y, et al. lncRNA-H19 in Fibroblasts Promotes Wound Healing in Diabetes. Diabetes. 2022;71:1562-1578 pubmed publisher |
Huang D, Camacho C, Martire S, Nagari A, Setlem R, Gong X, et al. Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation. Cancer Res. 2022;82:2361-2377 pubmed publisher |
Bristol J, Brand J, Ohashi M, Eichelberg M, Casco A, Nelson S, et al. Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells. PLoS Pathog. 2022;18:e1010453 pubmed publisher |
Ikemura N, Taminishi S, Inaba T, Arimori T, Motooka D, Katoh K, et al. An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo. Sci Transl Med. 2022;14:eabn7737 pubmed publisher |
Nair V, Mayer J, Vincendeau M. A protocol for CRISPR-mediated activation and repression of human endogenous retroviruses in human pluripotent stem cells. STAR Protoc. 2022;3:101281 pubmed publisher |
Lemster A, Sievers E, Pasternack H, Lazar Karsten P, Klümper N, Sailer V, et al. Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT. Cancers (Basel). 2022;14: pubmed publisher |
Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, et al. SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers. Neurobiol Dis. 2022;169:105737 pubmed publisher |
Zhang T, Zheng R, Li M, Yan C, Lan X, Tong B, et al. Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Res. 2022;50:4959-4973 pubmed publisher |
Wu L, Shukla V, Yadavalli A, Dinesh R, Xu D, Rao A, et al. HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Genes Dev. 2022;36:433-450 pubmed publisher |
Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, et al. PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Nat Commun. 2022;13:2176 pubmed publisher |
Zechner C, Henne W, Sathe A, Xing C, Hernandez G, Sun S, et al. Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT. J Biol Chem. 2022;298:101945 pubmed publisher |
Shan B, Barker C, Shao M, Zhang Q, Gupta R, Wu Y. Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. Cell Metab. 2022;34:783-799.e7 pubmed publisher |
Cao K, Riley J, Heilig R, Montes Gómez A, Vringer E, Berthenet K, et al. Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Dev Cell. 2022;57:1211-1225.e6 pubmed publisher |
Solvik T, Nguyen T, Tony Lin Y, Marsh T, Huang E, Wiita A, et al. Secretory autophagy maintains proteostasis upon lysosome inhibition. J Cell Biol. 2022;221: pubmed publisher |
Liao S, Wang K, Zhang L, Shi G, Wang Z, Chen Z, et al. PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells. Front Cell Dev Biol. 2022;10:864051 pubmed publisher |
Misek S, Foda B, Dexheimer T, Akram M, Conrad S, Schmidt J, et al. BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors. Front Oncol. 2022;12:766794 pubmed publisher |
Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, et al. TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Nat Commun. 2022;13:2165 pubmed publisher |
Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, et al. The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions. Cell Death Dis. 2022;13:386 pubmed publisher |
Morales E, Arnaiz C, Krystofiak E, Zanic M, Tyska M. Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli. Cell Rep. 2022;39:110692 pubmed publisher |
de Rooij M, Thus Y, Swier N, Beijersbergen R, Pals S, Spaargaren M. A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways. Nat Commun. 2022;13:2136 pubmed publisher |
Erdem A, Marin S, Pereira Martins D, Geugien M, Cunningham A, Pruis M, et al. Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. Nat Commun. 2022;13:2013 pubmed publisher |
Nelson J, Thin M, Evan T, Howell S, Wu M, Almeida B, et al. USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer. Nat Commun. 2022;13:2070 pubmed publisher |
Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, et al. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nat Commun. 2022;13:2059 pubmed publisher |
Flamand M, Meyer K. m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Nucleic Acids Res. 2022;50:4464-4483 pubmed publisher |
Zhang S, Gong T, Nan Y, Feng R, Liu Z, Chen H. MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas. Exp Cell Res. 2022;416:113158 pubmed publisher |
Anadon C, Yu X, Hänggi K, Biswas S, Chaurio R, Martin A, et al. Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Cancer Cell. 2022;40:545-557.e13 pubmed publisher |
Li J, Chen C, Li C, Hu Z, Tan J, Zeng L. Genome-Wide Knockout Screen Identifies EGLN3 Involving in Ammonia Neurotoxicity. Front Cell Dev Biol. 2022;10:820692 pubmed publisher |
Caruso L, Guo R, Keith K, Madzo J, Maestri D, Boyle S, et al. The nuclear lamina binds the EBV genome during latency and regulates viral gene expression. PLoS Pathog. 2022;18:e1010400 pubmed publisher |
Danziger O, Patel R, DeGrace E, Rosen M, Rosenberg B. Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor. PLoS Pathog. 2022;18:e1010464 pubmed publisher |
Guo D, Yu X, Wang D, Li Z, Zhou Y, Xu G, et al. SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection. J Virol. 2022;96:e0204221 pubmed publisher |
Millette M, Holland E, Tenpas T, Dent E. A Single Transcript Knockdown-Replacement Strategy Employing 5' UTR Secondary Structures to Precisely Titrate Rescue Protein Translation. Front Genome Ed. 2022;4:803375 pubmed publisher |
Muralimanoharan S, Shamby R, Stansbury N, Schenken R, de la Peña Avalos B, Javanmardi S, et al. Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids. Sci Rep. 2022;12:6169 pubmed publisher |
Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega R, et al. The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation. Nat Commun. 2022;13:1991 pubmed publisher |
Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, et al. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Sci Adv. 2022;8:eabk2376 pubmed publisher |
Fort L, Gama V, Macara I. Stem cell conversion to the cardiac lineage requires nucleotide signalling from apoptosing cells. Nat Cell Biol. 2022;24:434-447 pubmed publisher |
Li X, Chen W, Huang L, Zhu M, Zhang H, Si Y, et al. Sinomenine hydrochloride suppresses the stemness of breast cancer stem cells by inhibiting Wnt signaling pathway through down-regulation of WNT10B. Pharmacol Res. 2022;179:106222 pubmed publisher |
Rodda L, Morawski P, Pruner K, Fahning M, Howard C, Franko N, et al. Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity. Cell. 2022;185:1588-1601.e14 pubmed publisher |
Xuan W, Hsu W, Khan F, Dunterman M, Pang L, Wainwright D, et al. Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022;10:770-784 pubmed publisher |
Zhang Y, Donaher J, Das S, Li X, Reinhardt F, Krall J, et al. Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Nat Cell Biol. 2022;24:554-564 pubmed publisher |
Nishida T, Naguro I, Ichijo H. NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress. Cell Death Discov. 2022;8:195 pubmed publisher |
Ke P, Chang C, Hsiao Y. Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Cells. 2022;11: pubmed publisher |
Lewis M, Wisniewska K, King C, Li S, Coffey A, Kelly M, et al. Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher |
Treese C, Werchan J, von Winterfeld M, Berg E, Hummel M, Timm L, et al. Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas. Cancers (Basel). 2022;14: pubmed publisher |
Wang X, Wang R, Jiang K, Zhu M, Guo L, Wu C. PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex. Theranostics. 2022;12:2613-2630 pubmed publisher |
Ahamad S, Ali H, Secco I, Giacca M, Gupta D. Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction. Front Genet. 2022;13:866474 pubmed publisher |
Cai S, Zheng Z, Cheng J, Zhong L, Shao R, Zheng F, et al. Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication. Front Immunol. 2022;13:827709 pubmed publisher |
Haddock S, Alban T, Turcan S, Husic H, Rosiek E, Ma X, et al. Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells. Neoplasia. 2022;28:100790 pubmed publisher |
Dobson C, Reich A, Gaglione S, Smith B, Kim E, Dong J, et al. Antigen identification and high-throughput interaction mapping by reprogramming viral entry. Nat Methods. 2022;19:449-460 pubmed publisher |
Apriamashvili G, Vredevoogd D, Krijgsman O, Bleijerveld O, Ligtenberg M, de Bruijn B, et al. Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling. Nat Commun. 2022;13:1923 pubmed publisher |
Mateo F, He Z, Mei L, de Garibay G, Herranz C, Garcia N, et al. Modification of BRCA1-associated breast cancer risk by HMMR overexpression. Nat Commun. 2022;13:1895 pubmed publisher |
Liu H, Iketani S, Zask A, Khanizeman N, Bednářová E, Forouhar F, et al. Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun. 2022;13:1891 pubmed publisher |
Gill D, Parry A, Santos F, Okkenhaug H, Todd C, Hernando Herraez I, et al. Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. elife. 2022;11: pubmed publisher |
Marivin A, Ho R, Garcia Marcos M. DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes. J Cell Biol. 2022;221: pubmed publisher |
Ganesa S, Sule A, Sundaram R, Bindra R. Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma. Sci Rep. 2022;12:5827 pubmed publisher |
Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, et al. Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair. Nat Commun. 2022;13:1875 pubmed publisher |
Zhou T, Zhu X, Ye Z, Wang Y, Yao C, Xu N, et al. Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery. Nat Commun. 2022;13:1855 pubmed publisher |
Chu Z, Gu L, Hu Y, Zhang X, Li M, Chen J, et al. STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming. Nat Commun. 2022;13:1859 pubmed publisher |
Zhang G, Liu Y, Huang S, Qu S, Cheng D, Yao Y, et al. Enhancement of prime editing via xrRNA motif-joined pegRNA. Nat Commun. 2022;13:1856 pubmed publisher |
Minervina A, Pogorelyy M, Kirk A, Crawford J, Allen E, Chou C, et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells. Nat Immunol. 2022;23:781-790 pubmed publisher |
Piao X, Meng D, Zhang X, Song Q, Lv H, Jia Y. Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo. Sci Rep. 2022;12:5672 pubmed publisher |
Yang Y, Lu W, Ning M, Zhou X, Wan X, Mi Q, et al. A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1. Commun Biol. 2022;5:309 pubmed publisher |
Frey N, Tortola L, Egli D, Janjuha S, Rothgangl T, Marquart K, et al. Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing. Nat Commun. 2022;13:1804 pubmed publisher |
Dansu D, Liang J, Selcen I, Zheng H, Moore D, CASACCIA P. PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells. Front Cell Neurosci. 2022;16:820226 pubmed publisher |
Gomes A, Ilter D, Low V, Drápela S, Schild T, Mullarky E, et al. Altered propionate metabolism contributes to tumour progression and aggressiveness. Nat Metab. 2022;4:435-443 pubmed publisher |
Wang E, Dai Y, Rosen C, Schmitt M, Dong M, Ferre E, et al. High-throughput identification of autoantibodies that target the human exoproteome. Cell Rep Methods. 2022;2: pubmed publisher |
Li K, Wada S, Gosis B, Thorsheim C, Loose P, Arany Z. Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3. PLoS Biol. 2022;20:e3001594 pubmed publisher |
Stransky L, Vigeant S, Huang B, West D, Denize T, Walton E, et al. Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway. Proc Natl Acad Sci U S A. 2022;119:e2120403119 pubmed publisher |
Kadur Lakshminarasimha Murthy P, Sontake V, Tata A, Kobayashi Y, Macadlo L, Okuda K, et al. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Nature. 2022;604:111-119 pubmed publisher |
Gemble S, Wardenaar R, Keuper K, Srivastava N, Nano M, Macé A, et al. Genetic instability from a single S phase after whole-genome duplication. Nature. 2022;604:146-151 pubmed publisher |
Wrobel M, Cendrowski J, Szymańska E, Grębowicz Maciukiewicz M, Budick Harmelin N, Macias M, et al. ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway. Life Sci Alliance. 2022;5: pubmed publisher |
Zhang Y, Wang Y, Zhao G, Tanner E, Adli M, Matei D. FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway. J Clin Invest. 2022;132: pubmed publisher |
Miyake K, Takano N, Kazama H, Kikuchi H, Hiramoto M, Tsukahara K, et al. Ricolinostat enhances adavosertib‑induced mitotic catastrophe in TP53‑mutated head and neck squamous cell carcinoma cells. Int J Oncol. 2022;60: pubmed publisher |
Zhou Y, Fu Q, Shi H, Zhou G. CRISPR Guide RNA Library Screens in Human Induced Pluripotent Stem Cells. Methods Mol Biol. 2022;2549:233-257 pubmed publisher |
Wang M, Xiong C, Mercurio A. PD-LI promotes rear retraction during persistent cell migration by altering integrin β4 dynamics. J Cell Biol. 2022;221: pubmed publisher |
Krysler A, Cromwell C, Tu T, Jovel J, Hubbard B. Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences. Nat Commun. 2022;13:1617 pubmed publisher |
Joung J, Kirchgatterer P, Singh A, Cho J, Nety S, Larson R, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13:1606 pubmed publisher |
Sadraeian M, Junior F, Miranda M, Galinskas J, Fernandes R, da Cruz E, et al. Study of Viral Photoinactivation by UV-C Light and Photosensitizer Using a Pseudotyped Model. Pharmaceutics. 2022;14: pubmed publisher |
Skylar Scott M, Huang J, Lu A, Ng A, Duenki T, Liu S, et al. Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues. Nat Biomed Eng. 2022;6:449-462 pubmed publisher |
Zhao Y, Huang F, Zou Z, Bi Y, Yang Y, Zhang C, et al. Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72. Cell Mol Immunol. 2022;19:702-714 pubmed publisher |
Yoo S, Sinha A, Yang D, Altorki N, Tandon R, Wang W, et al. Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression. Nat Commun. 2022;13:1592 pubmed publisher |
Zhao Y, Chen R, Xiao D, Zhang L, Song D, Wen Y, et al. A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection. Int J Mol Sci. 2022;23: pubmed publisher |
Varghese P, Kishore U, Rajkumari R. Human C1q Regulates Influenza A Virus Infection and Inflammatory Response via Its Globular Domain. Int J Mol Sci. 2022;23: pubmed publisher |
Lu D, Nagelberg A, Chow J, Chen Y, Michalchuk Q, Somwar R, et al. MET Exon 14 Splice-Site Mutations Preferentially Activate KRAS Signaling to Drive Tumourigenesis. Cancers (Basel). 2022;14: pubmed publisher |
Miyazaki Y, Mori N, Akagi Y, Oda T, Kida Y. Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts. Cancers (Basel). 2022;14: pubmed publisher |
Warwick T, Schulz M, Gilsbach R, Brandes R, Seuter S. Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Nucleic Acids Res. 2022;50:3745-3763 pubmed publisher |
Wang G, Xiao X, Wang Y, Chu X, Dou Y, Minze L, et al. The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions. Cell Mol Immunol. 2022;19:687-701 pubmed publisher |
Dufour C, Scholtes C, Yan M, Chen Y, Han L, Li T, et al. The mTOR chromatin-bound interactome in prostate cancer. Cell Rep. 2022;38:110534 pubmed publisher |
Yao X, Li W, Li L, Li M, Zhao Y, Fang D, et al. YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis. Cell Death Dis. 2022;13:258 pubmed publisher |
Li P, Zhu X, Cao G, Wu R, Li K, Yuan W, et al. 1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells. J Immunother Cancer. 2022;10: pubmed publisher |
Hsu J, Laurent Rolle M, Pawlak J, Xia H, Kunte A, Hee J, et al. Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication. Mol Cell. 2022;82:1631-1642.e6 pubmed publisher |
Fang Z, Sun X, Wang X, Ma J, Palaia T, Rana U, et al. NOGOB receptor deficiency increases cerebrovascular permeability and hemorrhage via impairing histone acetylation-mediated CCM1/2 expression. J Clin Invest. 2022;132: pubmed publisher |
Guo T, Ma D, Lu T. Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation. ACS Synth Biol. 2022;11:1440-1453 pubmed publisher |
Tsaryk R, Yucel N, Leonard E, Díaz N, Bondareva O, Odenthal Schnittler M, et al. Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Sci Rep. 2022;12:4795 pubmed publisher |
Yang M, Gu J, Xu F, Wang Y, Wang H, Zhang B. The protective role of glucocerebrosidase/ceramide in rheumatoid arthritis. Connect Tissue Res. 2022;:1-9 pubmed publisher |
Jiang T, Yang J, Yang H, Chen W, Ji K, Xu Y, et al. SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC. Front Pharmacol. 2022;13:851089 pubmed publisher |
Balinda H, Sedgwick A, D SOUZA SCHOREY C. Mechanisms underlying melanoma invasion as a consequence of MLK3 loss. Exp Cell Res. 2022;415:113106 pubmed publisher |
Valdoz J, Franks N, Cribbs C, Jacobs D, Dodson E, Knight C, et al. Soluble ECM promotes organotypic formation in lung alveolar model. Biomaterials. 2022;283:121464 pubmed publisher |
Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, et al. PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles. J Nanobiotechnology. 2022;20:149 pubmed publisher |
Hu L, Zhang J, Lu Y, Fu B, Hu W. Estrogen receptor beta promotes endometriosis progression by upregulating CD47 expression in ectopic endometrial stromal cells. J Reprod Immunol. 2022;151:103513 pubmed publisher |
Biancon G, Joshi P, Zimmer J, Hunck T, Gao Y, Lessard M, et al. Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies. Mol Cell. 2022;82:1107-1122.e7 pubmed publisher |
Vaid x17e iulyt x117 K, Mac xe9 A, Battistella A, Beng W, Schauer K, Coppey M. Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking. elife. 2022;11: pubmed publisher |
Georgiou M, Ntavelou P, Stokes W, Roy R, Maher G, Stoilova T, et al. ATR and CDK4/6 inhibition target the growth of methotrexate-resistant choriocarcinoma. Oncogene. 2022;41:2540-2554 pubmed publisher |
Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman J, Xue X, et al. A genome-scale screen for synthetic drivers of T cell proliferation. Nature. 2022;603:728-735 pubmed publisher |
Coria L, Saposnik L, Pueblas Castro C, Castro E, Bruno L, Stone W, et al. A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Confers Protection Against SARS-CoV-2 Infection in Mice. Front Immunol. 2022;13:844837 pubmed publisher |
Huang Y, Zou Y, Jiao Y, Shi P, Nie X, Huang W, et al. Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect. Front Immunol. 2022;13:751296 pubmed publisher |
Böck D, Rothgangl T, Villiger L, Schmidheini L, Matsushita M, Mathis N, et al. In vivo prime editing of a metabolic liver disease in mice. Sci Transl Med. 2022;14:eabl9238 pubmed publisher |
Smith R, Takagishi S, Amici D, Metz K, Gayatri S, Alasady M, et al. HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state. Sci Adv. 2022;8:eabj6526 pubmed publisher |
Kummer D, Steinbacher T, Thölmann S, Schwietzer M, Hartmann C, Horenkamp S, et al. A JAM-A-tetraspanin-αvβ5 integrin complex regulates contact inhibition of locomotion. J Cell Biol. 2022;221: pubmed publisher |
Xiao W, Pinilla Baquero A, Faulkner J, Song X, Prabhakar P, Qiu H, et al. Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep. 2022;12:4352 pubmed publisher |
Sangree A, Griffith A, Szegletes Z, Roy P, DeWeirdt P, Hegde M, et al. Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2. Nat Commun. 2022;13:1318 pubmed publisher |
Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, et al. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Res. 2022;50:3323-3347 pubmed publisher |
Pallaseni A, Peets E, Koeppel J, Weller J, Vanderstichele T, Ho U, et al. Predicting base editing outcomes using position-specific sequence determinants. Nucleic Acids Res. 2022;50:3551-3564 pubmed publisher |
Krajka V, Vulinović F, Genova M, Tanzer K, Jijumon A, Bodakuntla S, et al. H-ABC- and dystonia-causing TUBB4A mutations show distinct pathogenic effects. Sci Adv. 2022;8:eabj9229 pubmed publisher |
Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok N, et al. In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2. Leukemia. 2022;36:1313-1323 pubmed publisher |
Sun T, Ding C, Zhang Y, Zhang Y, Lin C, Wu J, et al. MESH1 knockdown triggers proliferation arrest through TAZ repression. Cell Death Dis. 2022;13:221 pubmed publisher |
Sidorova O, Sayed S, Paszkowski Rogacz M, Seifert M, Camgoz A, Roeder I, et al. RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations. Cells. 2022;11: pubmed publisher |
Besse A, Kraus M, Mendez Lopez M, Maurits E, Overkleeft H, Driessen C, et al. Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors. Cells. 2022;11: pubmed publisher |
Xu H, LaFlamme S. Contribution of Endothelial Laminin-Binding Integrins to Cellular Processes Associated with Angiogenesis. Cells. 2022;11: pubmed publisher |
Sadangi S, Milosavljevic K, Castro Pérez E, Lares M, Singh M, Altameemi S, et al. Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes. Cancers (Basel). 2022;14: pubmed publisher |
V xe1 zquez Naharro A, Bustos Tauler J, Florist xe1 n A, Yuste L, Oltra S, Vinyals A, et al. Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival. Cancers (Basel). 2022;14: pubmed publisher |
Xu W, Zhang W, Cui L, Shi L, Zhu B, Lyu T, et al. Novel mutation of SIK1 gene causing a mild form of pediatric epilepsy in a Chinese patient. Metab Brain Dis. 2022;37:1207-1219 pubmed publisher |
Ren W, Ju X, Gong M, Lan J, Yu Y, Long Q, et al. Characterization of SARS-CoV-2 Variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 by Cell Entry and Immune Evasion. MBio. 2022;13:e0009922 pubmed publisher |
Tian S, Liu Y, Appleton E, Wang H, Church G, Dong M. Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms. Cell Rep. 2022;38:110476 pubmed publisher |
Giles J, Manne S, Freilich E, Oldridge D, Baxter A, George S, et al. Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers. Immunity. 2022;55:557-574.e7 pubmed publisher |
Pini V, Mariot V, Dumonceaux J, Counsell J, O Neill H, Farmer S, et al. Transiently expressed CRISPR/Cas9 induces wild-type dystrophin in vitro in DMD patient myoblasts carrying duplications. Sci Rep. 2022;12:3756 pubmed publisher |
Fanfone D, Wu Z, Mammi J, Berthenet K, Neves D, Weber K, et al. Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. elife. 2022;11: pubmed publisher |
Florian A, Woodley C, Wang J, Grieb B, Slota M, Guerrazzi K, et al. Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells. NAR Cancer. 2022;4:zcac007 pubmed publisher |
Deng W, Fan W, Tang T, Wan H, Zhao S, Tan Y, et al. Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4. Oxid Med Cell Longev. 2022;2022:3589525 pubmed publisher |
Chen W, Gard J, Epshtein Y, Camp S, Garcia J, Jacobson J, et al. Integrin Beta 4E Promotes Endothelial Phenotypic Changes and Attenuates Lung Endothelial Cell Inflammatory Responses. Front Physiol. 2022;13:769325 pubmed publisher |
Javaid S, Schaefer A, Goodwin C, Nguyen V, Massey F, Pierobon M, et al. Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther. 2022;21:762-774 pubmed publisher |
Li Y, Feng R, Yu X, Li L, Liu Y, Zhang R, et al. SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma. Life Sci. 2022;296:120447 pubmed publisher |
Omachi K, Kai H, Roberge M, Miner J. NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough. iScience. 2022;25:103891 pubmed publisher |
North K, Benbarche S, Liu B, Pangallo J, Chen S, Stahl M, et al. Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. Nat Biotechnol. 2022;: pubmed publisher |
Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, et al. ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models. Nat Commun. 2022;13:1121 pubmed publisher |
Bakkers M, Moon Walker A, Herlo R, Brusic V, Stubbs S, Hastie K, et al. CD164 is a host factor for lymphocytic choriomeningitis virus entry. Proc Natl Acad Sci U S A. 2022;119:e2119676119 pubmed publisher |
Ramirez N, Lee J, Zheng Y, Li L, Dennis B, Chen D, et al. ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. Nat Commun. 2022;13:1109 pubmed publisher |
Schene I, Joore I, Baijens J, Stevelink R, Kok G, Shehata S, et al. Mutation-specific reporter for optimization and enrichment of prime editing. Nat Commun. 2022;13:1028 pubmed publisher |
Turdo A, Gaggianesi M, Di Franco S, Veschi V, D Accardo C, Porcelli G, et al. Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51. Oncogene. 2022;41:2196-2209 pubmed publisher |
Shen H, Xu X, Fu Z, Xu C, Wang Y. The interactions of CAP and LYN with the insulin signaling transducer CBL play an important role in polycystic ovary syndrome. Metabolism. 2022;131:155164 pubmed publisher |
Vaidyanathan S, Salmi T, Sathiqu R, McConville M, Cox A, Brown K. YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth. Dev Cell. 2022;57:719-731.e8 pubmed publisher |
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, et al. The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Cell Biosci. 2022;12:20 pubmed publisher |
Zhang F, He P, Rodrigues A, Jeske W, Tandon R, Bates J, et al. Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate. Pharmaceuticals (Basel). 2022;15: pubmed publisher |
Hwang J, Kim Y, Lee K, Jang E, Woo C, Hong C, et al. Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naïve and -Recovered Korean Individuals. Vaccines (Basel). 2022;10: pubmed publisher |
Shinkawa Y, Imami K, Fuseya Y, Sasaki K, Ohmura K, Ishihama Y, et al. ABIN1 is a signal-induced autophagy receptor that attenuates NF-κB activation by recognizing linear ubiquitin chains. FEBS Lett. 2022;596:1147-1164 pubmed publisher |
Diao Y, Li Y, Wang Z, Wang S, Li P, Kong B. SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52. Cell Death Dis. 2022;13:179 pubmed publisher |
Pushparaj S, Zhu Z, Huang C, More S, Liang Y, Lin K, et al. Regulation of influenza A virus infection by Lnc-PINK1-2:5. J Cell Mol Med. 2022;26:2285-2298 pubmed publisher |
Zhang T, Zhao J, Liu T, Cheng W, Wang Y, Ding S, et al. A novel mechanism for NLRP3 inflammasome activation. Metabol Open. 2022;13:100166 pubmed publisher |
Cherbonneau F, Li G, Gokulnath P, Sahu P, Prunevieille A, Kitchen R, et al. TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells. iScience. 2022;25:103806 pubmed publisher |
Cai W, Srivastava P, Feng D, Lin Y, Vanderburg C, Xu Y, et al. Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. Mol Neurodegener. 2022;17:16 pubmed publisher |
Kapadia B, Roychowdhury A, Kayastha F, Nanaji N, Gartenhaus R. PARK2 regulates eIF4B-driven lymphomagenesis. Mol Cancer Res. 2022;: pubmed publisher |
Shramova E, Chumakov S, Shipunova V, Ryabova A, Telegin G, Kabashin A, et al. Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Light Sci Appl. 2022;11:38 pubmed publisher |
Boyero L, Martin Padron J, Fárez Vidal M, Rodriguez M, Andrades Á, Peinado P, et al. PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer. Cell Oncol (Dordr). 2022;45:323-332 pubmed publisher |
Chen Y, Cai Q, Pan C, Liu W, Li L, Liu J, et al. CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses. Cancer Immunol Res. 2022;10:525-539 pubmed publisher |
Ramírez Torres A, Gil J, Contreras S, Ramírez G, Valencia González H, Salazar Bustamante E, et al. Quantitative Proteomic Analysis of Cervical Cancer Tissues Identifies Proteins Associated With Cancer Progression. Cancer Genomics Proteomics. 2022;19:241-258 pubmed publisher |
Luo H, Zhu G, Eshelman M, Fung T, Lai Q, Wang F, et al. HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Mol Cell. 2022;82:833-851.e11 pubmed publisher |
Miao C, Tsujino T, Takai T, Gui F, Tsutsumi T, Sztupinszki Z, et al. RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. Sci Adv. 2022;8:eabl9794 pubmed publisher |
Fan C, Shi X, Zhao K, Wang L, Shi K, Liu Y, et al. Cell migration orchestrates migrasome formation by shaping retraction fibers. J Cell Biol. 2022;221: pubmed publisher |
Li H, Wu B, Kanchwala M, Cai J, Wang L, Xing C, et al. YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis. Nat Cell Biol. 2022;24:373-383 pubmed publisher |
Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, et al. Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-β Signaling Axis in Pancreatic Cancer. Gastroenterology. 2022;162:2004-2017.e2 pubmed publisher |
Song L, Luo J, Wang H, Huang D, Tan Y, Liu Y, et al. Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector. elife. 2022;11: pubmed publisher |
Blaha C, Ramakrishnan G, Jeon S, Nogueira V, Rho H, Kang S, et al. A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Nat Commun. 2022;13:899 pubmed publisher |
Sivakumar S, Qi S, Cheng N, Sathe A, Kanchwala M, Kumar A, et al. TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 2022;38:110395 pubmed publisher |
Kim K, Kabra A, Kim D, Xue Y, Huang Y, Hou P, et al. KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. Sci Adv. 2022;8:eabl4618 pubmed publisher |
Magg V, Klein P, Ruggieri A. Monitoring Virus-Induced Stress Granule Dynamics Using Long-Term Live-Cell Imaging. Methods Mol Biol. 2022;2428:325-348 pubmed publisher |
Chen R, Liu J, Li S, Li X, Huo Y, Yao Y, et al. Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants. BMC Med. 2022;20:68 pubmed publisher |
Wang Y, Xie S, Armendariz D, Hon G. Computational identification of clonal cells in single-cell CRISPR screens. BMC Genomics. 2022;23:135 pubmed publisher |
Lin P, Shen G, Guo K, Qin S, Pu Q, Wang Z, et al. Type III CRISPR-based RNA editing for programmable control of SARS-CoV-2 and human coronaviruses. Nucleic Acids Res. 2022;50:e47 pubmed publisher |
Sanchez Rivera F, Diaz B, Kastenhuber E, Schmidt H, Katti A, Kennedy M, et al. Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 2022;40:862-873 pubmed publisher |
Helsen C, Nguyen T, Vercruysse T, Wouters S, Daelemans D, Voet A, et al. The T850D Phosphomimetic Mutation in the Androgen Receptor Ligand Binding Domain Enhances Recruitment at Activation Function 2. Int J Mol Sci. 2022;23: pubmed publisher |
Vidal A, Redmer T. Tracking of Melanoma Cell Plasticity by Transcriptional Reporters. Int J Mol Sci. 2022;23: pubmed publisher |
Scambi I, Peroni D, Nodari A, Merigo F, Benati D, Boschi F, et al. The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age. Eur J Cell Biol. 2022;101:151206 pubmed publisher |
Stok J, Oosenbrug T, Ter Haar L, Gravekamp D, Bromley C, Zelenay S, et al. RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency. EMBO J. 2022;41:e109760 pubmed publisher |
Deng Z, Yao J, Xiao N, Han Y, Wu X, Ci C, et al. DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis. Lab Invest. 2022;: pubmed publisher |
Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, et al. BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection. Pharmacol Res. 2022;177:106122 pubmed publisher |
Li X, Morgan C, Goff L, Doetzlhofer A. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Sci Adv. 2022;8:eabj7651 pubmed publisher |
Román Fernández Á, Sandilands E, Bryant D. The Use of Three-Dimensional Cell Culture to Study Apicobasal Polarization and Lumen Formation. Methods Mol Biol. 2022;2438:439-454 pubmed publisher |
Ravi N, Wienert B, Wyman S, Bell H, George A, Mahalingam G, et al. Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. elife. 2022;11: pubmed publisher |
Su R, Dong L, Li Y, Gao M, He P, Liu W, et al. METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis. Nat Cell Biol. 2022;24:205-216 pubmed publisher |
Huang D, Wang Y, Thompson J, Yin T, Alexander P, Qin D, et al. Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression. Nat Cell Biol. 2022;24:230-241 pubmed publisher |
Zhu D, Xia J, Liu C, Fang C. Numb/Notch/PLK1 signaling pathway mediated hyperglycemic memory in pancreatic cancer cell radioresistance and the therapeutic effects of metformin. Cell Signal. 2022;93:110268 pubmed publisher |
Gerber P, Duncan L, Greenwood E, Marelli S, Naamati A, Teixeira Silva A, et al. A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection. PLoS Pathog. 2022;18:e1010265 pubmed publisher |
Hirakawa M, Tjahjono N, Light Y, Celebi A, Celebi N, Chintalapudi P, et al. Upregulation of CD14 in mesenchymal stromal cells accelerates lipopolysaccharide-induced response and enhances antibacterial properties. iScience. 2022;25:103759 pubmed publisher |
Zhang X, Hu Y, Pan Y, Xiong Y, Zhang Y, Han M, et al. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6. Oncogene. 2022;41:1821-1834 pubmed publisher |
Xiao Y, Chen J, Zhou H, Zeng X, Ruan Z, Pu Z, et al. Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy. Nat Commun. 2022;13:758 pubmed publisher |
Johnson F, Ferrarone J, Liu A, Brandstädter C, Munuganti R, Farnsworth D, et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 2022;38:110343 pubmed publisher |
Sun L, Wang Y, Wang X, Navarro Corcuera A, Ilyas S, Jalan Sakrikar N, et al. PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II. Cell Rep. 2022;38:110349 pubmed publisher |
Benbarche S, Lopez C, Salataj E, Aid Z, Thirant C, Laiguillon M, et al. Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia. Sci Adv. 2022;8:eabg9455 pubmed publisher |
Simon B, Lou H, Huet Calderwood C, Shi G, Boggon T, Turk B, et al. Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Nat Commun. 2022;13:749 pubmed publisher |
Machado M, Patente T, Rouille Y, Heumel S, Melo E, Deruyter L, et al. Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis. Front Immunol. 2022;13:773261 pubmed publisher |
Falcomatà C, Bärthel S, Widholz S, Schneeweis C, Montero J, Toska A, et al. Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. 2022;3:318-336 pubmed publisher |
Aoyama S, Yasuda S, Li H, Watanabe D, Umezawa Y, Okada K, et al. A novel chimeric antigen receptor (CAR) system using an exogenous protease, in which activation of T cells is controlled by expression patterns of cell‑surface proteins on target cells. Int J Mol Med. 2022;49: pubmed publisher |
Yan Y, Zhou B, Qian C, Vasquez A, Kamra M, Chatterjee A, et al. Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. Nat Commun. 2022;13:669 pubmed publisher |
Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, et al. Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML. Transl Oncol. 2022;18:101354 pubmed publisher |
Schmidt R, Steinhart Z, Layeghi M, Freimer J, Bueno R, Nguyen V, et al. CRISPR activation and interference screens decode stimulation responses in primary human T cells. Science. 2022;375:eabj4008 pubmed publisher |
Ichise H, Tsukamoto S, Hirashima T, Konishi Y, Oki C, Tsukiji S, et al. Functional visualization of NK cell-mediated killing of metastatic single tumor cells. elife. 2022;11: pubmed publisher |
Abdo A, Rintisch C, Gabriel C, Kramer A. Mutational scanning identified amino acids of the CLOCK exon 19-domain essential for circadian rhythms. Acta Physiol (Oxf). 2022;234:e13794 pubmed publisher |
Nguyen H, Wu T, Needs D, Zhang H, Perelli R, DeLuca S, et al. Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. Nat Commun. 2022;13:620 pubmed publisher |
Luo J, Zou H, Guo Y, Huang K, Ngan E, Li P. BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids. Cell Death Discov. 2022;8:47 pubmed publisher |
Song C, Wang L, Li Q, Liao B, Qiao W, Li Q, et al. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem Cell Res Ther. 2022;13:48 pubmed publisher |
Osokine I, Siewiera J, Rideaux D, Ma S, Tsukui T, Erlebacher A. Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface. Cell Rep. 2022;38:110329 pubmed publisher |
Chan H, Leong C, Lim C, Koh R. Roles of receptor-interacting protein kinase 1 in SH-SY5Y cells with beta amyloid-induced neurotoxicity. J Cell Mol Med. 2022;26:1434-1444 pubmed publisher |
Kamatani T, Otsuka R, Murata T, Wada H, Takahashi T, Mori A, et al. Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model. Inflamm Regen. 2022;42:4 pubmed publisher |
Krenning L, Sonneveld S, Tanenbaum M. Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition. elife. 2022;11: pubmed publisher |
Zou H, Luo J, Guo Y, Liu Y, Wang Y, Deng L, et al. RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7. Oncogene. 2022;41:1657-1672 pubmed publisher |
Siddaway R, Milos S, Vadivel A, Dobson T, Swaminathan J, Ryall S, et al. Splicing is an alternate oncogenic pathway activation mechanism in glioma. Nat Commun. 2022;13:588 pubmed publisher |
Ito Y, Takasawa A, Takasawa K, Murakami T, Akimoto T, Kyuno D, et al. Aberrant expression of claudin-6 contributes to malignant potentials and drug resistance of cervical adenocarcinoma. Cancer Sci. 2022;113:1519-1530 pubmed publisher |
S xf8 reng K, Pankiv S, Bergsmark C, Haugsten E, Dahl A, de la Ballina L, et al. ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration. J Cell Sci. 2022;135: pubmed publisher |
Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, et al. m6A modifications regulate intestinal immunity and rotavirus infection. elife. 2022;11: pubmed publisher |
Li Y, Shen Y, Xie M, Wang B, Wang T, Zeng J, et al. LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1. Signal Transduct Target Ther. 2022;7:30 pubmed publisher |
Shahi A, Kahle J, Hopkins C, Diakonova M. The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification. PLoS ONE. 2022;17:e0261098 pubmed publisher |
Pan Y, Han M, Zhang X, He Y, Yuan C, Xiong Y, et al. Discoidin domain receptor 1 promotes hepatocellular carcinoma progression through modulation of SLC1A5 and the mTORC1 signaling pathway. Cell Oncol (Dordr). 2022;45:163-178 pubmed publisher |
Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, et al. Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists. Mol Cancer Ther. 2022;21:594-606 pubmed publisher |
Grodzki M, Bluhm A, Schaefer M, Tagmount A, Russo M, Sobh A, et al. Genome-scale CRISPR screens identify host factors that promote human coronavirus infection. Genome Med. 2022;14:10 pubmed publisher |
Tegowski M, Flamand M, Meyer K. scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells. Mol Cell. 2022;82:868-878.e10 pubmed publisher |
Date Y, Matsuura A, Itakura E. Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT. Cell Death Discov. 2022;8:37 pubmed publisher |
Cheng W, Liu F, Ren Z, Chen W, Chen Y, Liu T, et al. Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens. Nat Commun. 2022;13:478 pubmed publisher |
Fu R, He W, Dou J, Villarreal O, Bedford E, Wang H, et al. Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Nat Commun. 2022;13:474 pubmed publisher |
Xie J, Ma G, Zhou L, He L, Zhang Z, Tan P, et al. Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth. Adv Sci (Weinh). 2022;9:e2103940 pubmed publisher |
Hagenlocher C, Siebert R, Taschke B, Wieske S, Hausser A, Rehm M. ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells. Cell Death Discov. 2022;8:34 pubmed publisher |
Tarangelo A, Rodencal J, Kim J, Magtanong L, Long J, Dixon S. Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity. Life Sci Alliance. 2022;5: pubmed publisher |
Gao Y, Yin Z, Qi Y, Peng H, Ma W, Wang R, et al. Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p. Cancer Cell Int. 2022;22:35 pubmed publisher |
Thölmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, et al. JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells. Cell Mol Life Sci. 2022;79:88 pubmed publisher |
Ding X, Chen J, Ma H, Liang Y, Wang Y, Zhang H, et al. KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation. Life Sci. 2022;293:120320 pubmed publisher |
Borisevich S, Khamitov E, Gureev M, Yarovaya O, Rudometova N, Zybkina A, et al. Simulation of Molecular Dynamics of SARS-CoV-2 S-Protein in the Presence of Multiple Arbidol Molecules: Interactions and Binding Mode Insights. Viruses. 2022;14: pubmed publisher |
Duguay B, Herod A, Pringle E, Monro S, Hetu M, Cameron C, et al. Photodynamic Inactivation of Human Coronaviruses. Viruses. 2022;14: pubmed publisher |
Zhang T, Wang Y, Yu H, Zhang T, Guo L, Xu J, et al. PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40. Cell Death Dis. 2022;13:68 pubmed publisher |
Walther J, Wilbie D, Tissingh V, xd6 ktem M, van der Veen H, Lou B, et al. Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction. Pharmaceutics. 2022;14: pubmed publisher |
Benjamin R, Banerjee A, Wu X, Geurink C, Buczek L, Eames D, et al. XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks. Int J Mol Sci. 2022;23: pubmed publisher |
Remy J, Linder B, Weirauch U, Day B, Stringer B, Herold Mende C, et al. STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Cancers (Basel). 2022;14: pubmed publisher |
Clees A, Stolp V, Häupl B, Fuhrmann D, Wempe F, Seibert M, et al. Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. Cells. 2022;11: pubmed publisher |
Maia N, Potelle S, Yildirim H, Duvet S, Akula S, Schulz C, et al. Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder. Am J Hum Genet. 2022;109:345-360 pubmed publisher |
Guo X, Elledge S. V-CARMA: A tool for the detection and modification of antigen-specific T cells. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher |
Hirota K, Hirashima T, Horikawa K, Yasoda A, Matsuda M. C-type Natriuretic Peptide-induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes. Endocrinology. 2022;163: pubmed publisher |
Rufino Ramos D, Lule S, Mahjoum S, Ughetto S, Cristopher Bragg D, Pereira de Almeida L, et al. Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo. Biomaterials. 2022;281:121366 pubmed publisher |
Sun C, Wei J, Long Z, Zhao W, Huangfu Q, Xie Q, et al. Spindle pole body component 24 homolog potentiates tumor progression via regulation of SRY-box transcription factor 2 in clear cell renal cell carcinoma. FASEB J. 2022;36:e22086 pubmed publisher |
Mudd P, Minervina A, Pogorelyy M, Turner J, Kim W, Kalaidina E, et al. SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans. Cell. 2022;185:603-613.e15 pubmed publisher |
Abu Libdeh B, Jhujh S, Dhar S, Sommers J, Datta A, Longo G, et al. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest. 2022;132: pubmed publisher |
Li X, Straub J, Medeiros T, Mehra C, den Brave F, Peker E, et al. Mitochondria shed their outer membrane in response to infection-induced stress. Science. 2022;375:eabi4343 pubmed publisher |
Yang Y, Wu Y, Meng X, Wang Z, Younis M, Liu Y, et al. SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK. Cell Death Differ. 2022;: pubmed publisher |
Luke C, Markovina S, Good M, Wight I, Thomas B, Linneman J, et al. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol. 2022;5:47 pubmed publisher |
Polyanskaya S, Moreno R, Lu B, Feng R, Yao Y, Irani S, et al. SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia. Cell Rep. 2022;38:110233 pubmed publisher |
Machino H, Kaneko S, Komatsu M, Ikawa N, Asada K, Nakato R, et al. The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma. Commun Biol. 2022;5:39 pubmed publisher |
Alerasool N, Leng H, Lin Z, Gingras A, Taipale M. Identification and functional characterization of transcriptional activators in human cells. Mol Cell. 2022;82:677-695.e7 pubmed publisher |
Schaefer E, Wang H, Karp H, Meyer C, Cejas P, Gearhart M, et al. BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes. Blood Cancer Discov. 2022;3:116-135 pubmed publisher |
Hanke L, Das H, Sheward D, Perez Vidakovics L, Urgard E, Moliner Morro A, et al. A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo. Nat Commun. 2022;13:155 pubmed publisher |
Aass K, Mjelle R, Kastnes M, Tryggestad S, van den Brink L, Aass Roseth I, et al. Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. iScience. 2022;25:103605 pubmed publisher |
Li P, Li S, Gao S, Dong D. A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients. Med Hypotheses. 2022;159:110754 pubmed publisher |
Kimura H, Paranal R, Nanda N, Wood L, Eshleman J, Hruban R, et al. Functional CDKN2A assay identifies frequent deleterious alleles misclassified as variants of uncertain significance. elife. 2022;11: pubmed publisher |
Danielsson B, Peters H, Bathula K, Spear L, Noll N, Dahl K, et al. Progerin-Expressing Endothelial Cells are Unable to Adapt to Shear Stress. Biophys J. 2022;: pubmed publisher |
Koritala B, Porter K, Sarkar S, Gaddameedhi S. Circadian disruption and cisplatin chronotherapy for mammary carcinoma. Toxicol Appl Pharmacol. 2022;436:115863 pubmed publisher |
Hwang J, Wang H, Lu Y, Ikawa M, Chung J. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane. Cell Rep. 2022;:110226 pubmed publisher |
Lee G, Huang S, Aw W, Rathod M, Cho C, Ligler F, et al. Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow. Biofabrication. 2022;14: pubmed publisher |
Jakubik C, Weckerly C, Hammond G, Bresnick A, Backer J. PIP3 abundance overcomes PI3K signaling selectivity in invadopodia. FEBS Lett. 2022;: pubmed publisher |
Wang B, Li J, Liu L, Song G. Insulin sensitivity in the aged heart is improved by down-regulation of KAT7 in vivo and in vitro. Cell Cycle. 2022;:1-13 pubmed publisher |
Pan C, Cai Q, Li X, Li L, Yang L, Chen Y, et al. Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1. Cell Mol Immunol. 2022;: pubmed publisher |
Zheng A, Dubuis G, Georgieva M, Mendes Ferreira C, Serulla M, Del Carmen Conde Rubio M, et al. HDLs extract lipophilic drugs from cells. J Cell Sci. 2022;135: pubmed publisher |
Zeng J, Xie X, Feng X, Xu L, Han J, Yu D, et al. Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice. EBioMedicine. 2022;75:103803 pubmed publisher |
Wang P, Gong S, Liao B, Pan J, Wang J, Zou D, et al. HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions. J Cancer. 2022;13:1-14 pubmed publisher |
Engedal N, Sønstevold T, Beese C, Selladurai S, Melcher T, Simensen J, et al. Measuring Autophagic Cargo Flux with Keima-Based Probes. Methods Mol Biol. 2022;2445:99-115 pubmed publisher |
Will R, Bauer K, Kudla M, Montero Vergara J, Wiemann S, Jendrossek V, et al. A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux Assessment. Methods Mol Biol. 2022;2445:75-98 pubmed publisher |
Zhai J, Liu Z, Wang H, Huang G, Man L. GPNMB overexpression is associated with extensive bone metastasis and poor prognosis in renal cell carcinoma. Oncol Lett. 2022;23:36 pubmed publisher |
Kato H, Tateishi K, Fujiwara H, Nakatsuka T, Yamamoto K, Kudo Y, et al. MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages. Gastroenterology. 2022;162:1272-1287.e16 pubmed publisher |
Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska E. RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. RNA. 2022;28:353-370 pubmed publisher |
Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, et al. Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. Cancer Sci. 2022;113:971-985 pubmed publisher |
Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, et al. Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules. Int J Oncol. 2022;60: pubmed publisher |
Ahmadinejad F, Bos T, Hu B, Britt E, Koblinski J, Souers A, et al. Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin. Mol Pharmacol. 2022;101:168-180 pubmed publisher |
Voeltzel T, Fossard G, Degaud M, Geistlich K, Gadot N, Jeanpierre S, et al. A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes. Biomater Sci. 2022;10:485-498 pubmed publisher |
Pivniouk V, Pivniouk O, Devries A, Uhrlaub J, Michael A, Pivniouk D, et al. The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. J Allergy Clin Immunol. 2022;149:923-933.e6 pubmed publisher |
Lin Y, Huang C, Gao H, Li X, Lin Q, Zhou S, et al. AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. J Cell Sci. 2022;135: pubmed publisher |
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Xu Z, et al. HSP27 protects against ferroptosis of glioblastoma cells. Hum Cell. 2022;35:238-249 pubmed publisher |
Heumüller A, Jones A, Mourão A, Klangwart M, Shi C, Wittig I, et al. Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses. Circ Res. 2022;130:67-79 pubmed publisher |
Miyamoto S, Nagano Y, Miyazaki M, Nagamura Y, Sasaki K, Kawamura T, et al. Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma. Cancer Lett. 2022;526:335-345 pubmed publisher |
Liu F, Zhao Q, Su Y, Lv J, Gai Y, Liu S, et al. Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance. Exp Hematol. 2022;105:39-49 pubmed publisher |
Misek S, Newbury P, Chekalin E, Paithankar S, Doseff A, Chen B, et al. Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. Mol Pharmacol. 2022;101:1-12 pubmed publisher |
Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, et al. Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2022;21:89-99 pubmed publisher |
Kwanten B, Neggers J, Daelemans D. Target Identification of Small Molecules Using Large-Scale CRISPR-Cas Mutagenesis Scanning of Essential Genes. Methods Mol Biol. 2022;2377:43-67 pubmed publisher |
Jiang L, Liang J, Huang W, Ma J, Park K, Wu Z, et al. CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Mol Ther. 2022;30:54-74 pubmed publisher |
Lin S, Hirayama D, Maryu G, Matsuda K, Hino N, Deguchi E, et al. Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration. Life Sci Alliance. 2022;5: pubmed publisher |
Quan Y, Shan X, Hu M, Jin P, Ma J, Fan J, et al. YAP inhibition promotes endothelial cell differentiation from pluripotent stem cell through EC master transcription factor FLI1. J Mol Cell Cardiol. 2022;163:81-96 pubmed publisher |
Yeung S, Zhou Y, Zou W, Chan W, Ching Y. TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Cancer Lett. 2022;524:70-81 pubmed publisher |
Zhu W, Cheng Y, Wang Z, Ji L, Ma J, Yan Y, et al. The identification of a shorter cyclic GMP-AMP synthase gene from chickens and bioinformatics analysis of its potential signaling in IFN regulation. Dev Comp Immunol. 2022;127:104266 pubmed publisher |
Hadrava Vanova K, Pang Y, Krobova L, Kraus M, Nahacka Z, Boukalova S, et al. Germline SUCLG2 Variants in Patients With Pheochromocytoma and Paraganglioma. J Natl Cancer Inst. 2022;114:130-138 pubmed publisher |
Gao Y, Xiong J, Chu Q, Ji W. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth. J Cell Sci. 2022;135: pubmed publisher |
López Muneta L, Linares J, Casis O, Martínez Ibáñez L, González Miqueo A, Bezunartea J, et al. Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts. Front Cell Dev Biol. 2021;9:797927 pubmed publisher |
Zhai K, Huang Z, Huang Q, Tao W, Fang X, Zhang A, et al. Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells. Nat Cancer. 2021;2:1136-1151 pubmed publisher |
Zhang Y, Zhang X, Zhang H, Song P, Pan W, Xu P, et al. Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization. Front Immunol. 2021;12:811164 pubmed publisher |
McCall J, Varney M, Rice E, Dziadowicz S, Hall C, Blethen K, et al. Prenatal Cadmium Exposure Alters Proliferation in Mouse CD4+ T Cells via LncRNA Snhg7. Front Immunol. 2021;12:720635 pubmed publisher |
Katzman C, Israely T, Melamed S, Politi B, Sittner A, Yahalom Ronen Y, et al. Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection. Viruses. 2021;14: pubmed publisher |
Correia M, Stojanovic A, Wels W, Cerwenka A. Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity. Oncoimmunology. 2021;10:1973783 pubmed publisher |
Wu W, Xu H, Meng Z, Zhu J, Xiong S, Xia X, et al. Axl Is Essential for in-vitro Angiogenesis Induced by Vitreous From Patients With Proliferative Diabetic Retinopathy. Front Med (Lausanne). 2021;8:787150 pubmed publisher |
Yuan Y, Zhang X, Chen R, Li Y, Wu B, Li R, et al. A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2. Cell Rep. 2021;:110256 pubmed publisher |
Cha Y, Kim T, Jeon J, Jang Y, Kim P, Lopes C, et al. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes. Cell Rep. 2021;37:110155 pubmed publisher |
Cona B, Hayashi T, Yamada A, Shimizu N, Yokota N, Nakato R, et al. The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR-Cas9 screen. FEBS Open Bio. 2021;: pubmed publisher |
Sigurdardottir A, Jonasdottir A, Asbjarnarson A, Helgudottir H, Gudjonsson T, Traustadóttir G. Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492. J Mammary Gland Biol Neoplasia. 2021;: pubmed publisher |
Krivitsky A, Pozzi S, Yeini E, Israeli Dangoor S, Zur T, Golan S, et al. Sulfonated Amphiphilic Poly(α)glutamate Amine-A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors. Pharmaceutics. 2021;13: pubmed publisher |
Varghese P, Mukherjee S, Al Mohanna F, Saleh S, Almajhdi F, Beirag N, et al. Human Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection. Front Immunol. 2021;12:747654 pubmed publisher |
Gaeta I, Meenderink L, Tyska M. A protocol for imaging microvilli biogenesis on the surface of cultured porcine kidney epithelial cell monolayers. STAR Protoc. 2021;2:100998 pubmed publisher |
Sønstevold T, Engedal N, Torgersen M. Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy. Cells. 2021;10: pubmed publisher |
Song Y, He P, Rodrigues A, Datta P, Tandon R, Bates J, et al. Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum. Mar Drugs. 2021;19: pubmed publisher |
Gutierrez C, Al Khafaji A, Brenner E, Johnson K, Gohil S, Lin Z, et al. Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment. Nat Cancer. 2021;2:758-772 pubmed publisher |
Chen W, Ding Y, Liu D, Lu Z, Wang Y, Yuan Y. Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis. PLoS Pathog. 2021;17:e1009600 pubmed publisher |
Taniguchi S, Tanaka Y, Elhance A, Oshimori N. A mechanistic basis for the malignant progression of salivary gland tumors. iScience. 2021;24:103508 pubmed publisher |
Pesch A, Hirsh N, Michmerhuizen A, Jungles K, Wilder Romans K, Chandler B, et al. RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes. JCI Insight. 2021;: pubmed publisher |
Clark L, Clark S, Lin C, Liu J, Coscia A, Nabel K, et al. VLDLR and ApoER2 are receptors for multiple alphaviruses. Nature. 2021;: pubmed publisher |
Hyun J, Lee M, Rehman J, Pajcini K, Malik A. Notch1 promotes revascularization through modulation of downstream vascular patterning signaling. J Physiol. 2021;: pubmed publisher |
Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, et al. Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Nat Commun. 2021;12:7322 pubmed publisher |
Choi K, Kim J, Kong X, Isik M, Zhang J, Lim H, et al. Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Cell Rep. 2021;37:110104 pubmed publisher |
Zhao L, Zhong K, Zhao J, Yong X, Tong A, Jia D. SARS-CoV-2 spike protein harnesses SNX27-mediated endocytic recycling pathway. MedComm (2020). 2021;: pubmed publisher |
Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, et al. Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. elife. 2021;10: pubmed publisher |
Pan T, Chen R, He X, Yuan Y, Deng X, Li R, et al. Infection of wild-type mice by SARS-CoV-2 B.1.351 variant indicates a possible novel cross-species transmission route. Signal Transduct Target Ther. 2021;6:420 pubmed publisher |
Hu L, Chen L, Xiao Z, Zheng X, Chen Y, Xian N, et al. Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy. JCI Insight. 2021;: pubmed publisher |
Ding L, Sun W, Balaz M, He A, Klug M, Wieland S, et al. Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. Nat Metab. 2021;3:1648-1661 pubmed publisher |
Amin R, Shukla A, Zhu J, Kim S, Wang P, Tian S, et al. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. Nat Commun. 2021;12:7216 pubmed publisher |
Reint G, Li Z, Labun K, Keskitalo S, Soppa I, Mamia K, et al. Rapid genome editing by CRISPR-Cas9-POLD3 fusion. elife. 2021;10: pubmed publisher |
Yan Y, Zhou B, Lee Y, You S, Freeman M, Yang W. BoxCar and shotgun proteomic analyses reveal molecular networks regulated by UBR5 in prostate cancer. Proteomics. 2021;:e2100172 pubmed publisher |
Bi Y, Guo X, Zhang M, Zhu K, Shi C, Fan B, et al. Bone marrow derived-mesenchymal stem cell improves diabetes-associated fatty liver via mitochondria transformation in mice. Stem Cell Res Ther. 2021;12:602 pubmed publisher |
Léger A, Amaral P, Pandolfini L, Capitanchik C, Capraro F, Miano V, et al. RNA modifications detection by comparative Nanopore direct RNA sequencing. Nat Commun. 2021;12:7198 pubmed publisher |
Yu Z, Deng P, Chen Y, Liu S, Chen J, Yang Z, et al. Inhibition of the PLK1-Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer. Adv Sci (Weinh). 2021;8:e2100759 pubmed publisher |
Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, et al. Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. iScience. 2021;24:103448 pubmed publisher |
Zhao J, Xiu Y, Fu L, Dong Q, Borcherding N, Wang Y, et al. TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9. iScience. 2021;24:103425 pubmed publisher |
Magdy T, Jouni M, Kuo H, Weddle C, Lyra Leite D, Fonoudi H, et al. Identification of Drug Transporter Genomic Variants and Inhibitors that Protect Against Doxorubicin-Induced Cardiotoxicity. Circulation. 2021;: pubmed publisher |
Kim H, Grimes S, Hooker A, Lau B, Ji H. Single-cell characterization of CRISPR-modified transcript isoforms with nanopore sequencing. Genome Biol. 2021;22:331 pubmed publisher |
Lee S, Jang S, Kang J, Park S, Han Y, Nam H, et al. MG1141A as a Highly Potent Monoclonal Neutralizing Antibody Against SARS-CoV-2 Variants. Front Immunol. 2021;12:778829 pubmed publisher |
Cocola C, Magnaghi V, Abeni E, Pelucchi P, Martino V, Vilardo L, et al. Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy. Front Cell Neurosci. 2021;15:703431 pubmed publisher |
Campden R, Warren A, Greene C, Chiriboga J, Arnold C, Aggarwal D, et al. Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation. J Biol Chem. 2021;:101459 pubmed publisher |
Du J, Xiang Y, Liu H, Liu S, Kumar A, Xing C, et al. RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis. Nat Commun. 2021;12:7067 pubmed publisher |
Grzelak C, Goddard E, Lederer E, Rajaram K, Dai J, Shor R, et al. Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings. Cancer Cell. 2021;: pubmed publisher |
Yu Y, Ju X, Ding Q. A Nucleocapsid-based Transcomplementation Cell Culture System of SARS-CoV-2 to Recapitulate the Complete Viral Life Cycle. Bio Protoc. 2021;11:e4257 pubmed publisher |
Song L, Chen J, Sun A, Schekman R. APEX-mediated Proximity Labeling of Proteins in Cells Targeted by Extracellular Vesicles. Bio Protoc. 2021;11:e4213 pubmed publisher |
Dong X, Zhang Q, Hao J, Xie Q, Xu B, Zhang P, et al. Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. Front Oncol. 2021;11:754206 pubmed publisher |
Reisman B, Guo H, Ramsey H, Wright M, Reinfeld B, Ferrell P, et al. Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Nat Chem Biol. 2021;: pubmed publisher |
Needham E, Hingst J, Parker B, Morrison K, Yang G, Onslev J, et al. Personalized phosphoproteomics identifies functional signaling. Nat Biotechnol. 2021;: pubmed publisher |
Hwang T, Parker S, Hill S, Ilunga M, Grant R, Mouneimne G, et al. A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers. elife. 2021;10: pubmed publisher |
Uchida T, Park S, Inuzuka T, Zhang M, Allen J, Chayama K, et al. Genetically edited hepatic cells expressing the NTCP-S267F variant are resistant to hepatitis B virus infection. Mol Ther Methods Clin Dev. 2021;23:597-605 pubmed publisher |
Liu Y, Williams S, Jones H, Keavney B, Choy M. A novel RNA-mediated mechanism causing down-regulation of insulating promoter interactions in human embryonic stem cells. Sci Rep. 2021;11:23233 pubmed publisher |
Pennemann F, Mussabekova A, Urban C, Stukalov A, Andersen L, Grass V, et al. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Nat Commun. 2021;12:7009 pubmed publisher |
Song T, Long M, Zhao H, Zou M, Fan H, Liu Y, et al. Tumor evolution selectively inactivates the core microRNA machinery for immune evasion. Nat Commun. 2021;12:7003 pubmed publisher |
Lin J, Guo D, Liu H, Zhou W, Wang C, Muller I, et al. The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity. Cancer Immunol Res. 2021;9:1413-1424 pubmed publisher |
Ge Q, Chen J, Li G, Tan X, Song J, Ning D, et al. GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma. Clin Transl Med. 2021;11:e635 pubmed publisher |
Liu D, Zhang T, Chen X, Zhang B, Wang Y, Xie M, et al. ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY. Cell Death Dis. 2021;12:1113 pubmed publisher |
Yang J, Chi W, Liang J, Takayanagi S, Iglesias P, Huang C. Deciphering cell signaling networks with massively multiplexed biosensor barcoding. Cell. 2021;184:6193-6206.e14 pubmed publisher |
Laubscher D, Gryder B, SUNKEL B, Andresson T, Wachtel M, Das S, et al. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021;12:6924 pubmed publisher |
Synowiec A, Jedrysik M, Branicki W, Klajmon A, Lei J, Owczarek K, et al. Identification of Cellular Factors Required for SARS-CoV-2 Replication. Cells. 2021;10: pubmed publisher |
Nath A, Rayabaram J, Ijee S, Bagchi A, Chaudhury A, Roy D, et al. Comprehensive Analysis of microRNAs in Human Adult Erythropoiesis. Cells. 2021;10: pubmed publisher |
Faria M, Domingues R, Bugalho M, Matos P, Silva A. MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells. Cancers (Basel). 2021;13: pubmed publisher |
Li N, Nguyen R, Thiele C, Ho M. Preclinical testing of chimeric antigen receptor T cells in neuroblastoma mouse models. STAR Protoc. 2021;2:100942 pubmed publisher |
Song S, Manook M, Kwun J, Jackson A, Knechtle S, Kelsoe G. A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines. Commun Biol. 2021;4:1338 pubmed publisher |
Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, et al. Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity. Nat Commun. 2021;12:6896 pubmed publisher |
Zhu T, Xiao Y, Meng X, Tang L, Li B, Zhao Z, et al. Nanovesicles derived from bispecific CAR-T cells targeting the spike protein of SARS-CoV-2 for treating COVID-19. J Nanobiotechnology. 2021;19:391 pubmed publisher |
An Y, Kim S. Facile Fabrication of Three-Dimensional Hydrogel Film with Complex Tissue Morphology. Bioengineering (Basel). 2021;8: pubmed publisher |
Feng Y, Li C, Stewart J, Barbulescu P, Desivo N, Alvarez Quilón A, et al. FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. 2021;600:324-328 pubmed publisher |
Morgan M, Popova I, Vaidya A, Burg J, Marunde M, Rendleman E, et al. A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer. Genes Dev. 2021;35:1642-1656 pubmed publisher |
Brohl A, Sindiri S, Wei J, Milewski D, Chou H, Song Y, et al. Immuno-transcriptomic profiling of extracranial pediatric solid malignancies. Cell Rep. 2021;37:110047 pubmed publisher |
King R, Lin Z, Balbin Cuesta G, Myers G, Friedman A, Zhu G, et al. SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II. Sci Adv. 2021;7:eabj5293 pubmed publisher |
Kalejaiye T, Bhattacharya R, Burt M, Travieso T, Okafor A, Mou X, et al. BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes. bioRxiv. 2021;: pubmed publisher |
Otani S, Date Y, Ueno T, Ito T, Kajikawa S, Omori K, et al. Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Oncogene. 2021;: pubmed publisher |
Kruse T, Benz C, Garvanska D, Lindqvist R, Mihalic F, Coscia F, et al. Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities. Nat Commun. 2021;12:6761 pubmed publisher |
Di Rienzo M, Romagnoli A, Ciccosanti F, Refolo G, Consalvi V, Arena G, et al. AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability. Autophagy. 2021;:1-11 pubmed publisher |
Long L, Wei J, Lim S, Raynor J, Shi H, Connelly J, et al. CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Nature. 2021;600:308-313 pubmed publisher |
Ryzhakov G, Almuttaqi H, Corbin A, Berthold D, Khoyratty T, Eames H, et al. Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation. Nat Commun. 2021;12:6702 pubmed publisher |
Barroso Gomila O, Trulsson F, Muratore V, Canosa I, Merino Cacho L, Cortazar A, et al. Identification of proximal SUMO-dependent interactors using SUMO-ID. Nat Commun. 2021;12:6671 pubmed publisher |
Gao Y, Liu Y, Sun L, Ouyang X, Zhu C, Qin X. MAD2L1 Functions As a Novel Diagnostic and Predictive Biomarker in Cholangiocarcinoma. Genet Test Mol Biomarkers. 2021;25:685-695 pubmed publisher |
Singh S, Quarni W, Goralski M, Wan S, Jin H, Van De Velde L, et al. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021;7:eabj5405 pubmed publisher |
Valcourt E, Manguiat K, Robinson A, Lin Y, Abe K, Mubareka S, et al. Evaluating Humoral Immunity against SARS-CoV-2: Validation of a Plaque-Reduction Neutralization Test and a Multilaboratory Comparison of Conventional and Surrogate Neutralization Assays. Microbiol Spectr. 2021;9:e0088621 pubmed publisher |
Hogan A, Sathyan K, Willis A, Khurana S, Srivastava S, Zasadzińska E, et al. UBR7 acts as a histone chaperone for post-nucleosomal histone H3. EMBO J. 2021;40:e108307 pubmed publisher |
Krantz S, Kim Y, Srivastava S, Leasure J, Toth P, Marsboom G, et al. Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation. J Biol Chem. 2021;297:101410 pubmed publisher |
Liu W, Gao M, Li L, Chen Y, Fan H, Cai Q, et al. Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens. Cell Mol Immunol. 2021;18:2660-2672 pubmed publisher |
Innes J, Lowe A, Fonseca R, Aley N, El Hassan T, Constantinou M, et al. Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment. Lab Invest. 2021;: pubmed publisher |
El Houjeiri L, Biondini M, Paquette M, Kuasne H, Pacis A, Park M, et al. Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis. J Clin Invest. 2021;131: pubmed publisher |
Missios P, da Rocha E, Pearson D, Philipp J, Aleman M, Pirouz M, et al. LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. J Clin Invest. 2021;131: pubmed publisher |
Babagana M, Brown L, Slabodkin H, Kichina J, Kandel E. Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT. Int J Mol Sci. 2021;22: pubmed publisher |
Spliid C, Toledo A, Sanderson P, Mao Y, Gatto F, Gustavsson T, et al. The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility. J Biol Chem. 2021;297:101391 pubmed publisher |
Woodward A, Feeley M, Rinaldi J, ARGUESO P. CRISPR/Cas9 genome editing reveals an essential role for basigin in maintaining a nonkeratinized squamous epithelium in cornea. FASEB Bioadv. 2021;3:897-908 pubmed publisher |
Payapilly A, Guilbert R, Descamps T, White G, Magee P, Zhou C, et al. TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change. Cell Rep. 2021;37:109979 pubmed publisher |
Fang F, Cao W, Zhu W, Lam N, Li L, Gaddam S, et al. The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age. Cell Rep. 2021;37:109981 pubmed publisher |
Pan M, Wright W, Chapple R, Zubair A, Sandhu M, Batchelder J, et al. The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Nat Commun. 2021;12:6468 pubmed publisher |
Kakihara K, Asamizu K, Moritsugu K, Kubo M, Kitaguchi T, Endo A, et al. Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain. Commun Biol. 2021;4:1272 pubmed publisher |
Van Sciver N, Ohashi M, Nawandar D, Pauly N, Lee D, Makielski K, et al. ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells. PLoS Pathog. 2021;17:e1010045 pubmed publisher |
Ren W, Lan J, Ju X, Gong M, Long Q, Zhu Z, et al. Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption. PLoS Pathog. 2021;17:e1010053 pubmed publisher |
Kiritsy M, Ankley L, Trombley J, Huizinga G, Lord A, Orning P, et al. A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation. elife. 2021;10: pubmed publisher |
Farooq U, Notani D. Optimized protocol to create deletion in adherent cell lines using CRISPR/Cas9 system. STAR Protoc. 2021;2:100857 pubmed publisher |
Jiang Y, Wu S, Chen Y, Zhang Z, Tao Y, Xie Y, et al. CEBPG promotes acute myeloid leukemia progression by enhancing EIF4EBP1. Cancer Cell Int. 2021;21:598 pubmed publisher |
Chen B, Shi H, Zhang J, Zhou C, Han M, Jiang W, et al. CRISPR-based RNA-binding protein mapping in live cells. Biochem Biophys Res Commun. 2021;583:79-85 pubmed publisher |
Liao X, Qian X, Zhang Z, Tao Y, Li Z, Zhang Q, et al. ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via MYC-Targets and G2M-Checkpoint Signaling Pathways. Front Oncol. 2021;11:753119 pubmed publisher |
Li Z, Zhang J, Ai H. Genetically Encoded Green Fluorescent Biosensors for Monitoring UDP-GlcNAc in Live Cells. ACS Cent Sci. 2021;7:1763-1770 pubmed publisher |
Kiritsy M, McCann K, MOTT D, Holland S, Behar S, Sassetti C, et al. Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells. elife. 2021;10: pubmed publisher |
Wang J, Kamath T, Mazur C, Mirzamohammadi F, Rotter D, Hojo H, et al. Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. Nat Commun. 2021;12:6271 pubmed publisher |
Wang M, Li S, Guo W, Wang L, Huang J, Zhuo J, et al. CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity. Carcinogenesis. 2021;: pubmed publisher |
Trofimenko E, Grasso G, Heulot M, Chevalier N, Deriu M, Dubuis G, et al. Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore. elife. 2021;10: pubmed publisher |
Duke C, Bach S, Revanna J, Sultan F, Southern N, Davis M, et al. An Improved CRISPR/dCas9 Interference Tool for Neuronal Gene Suppression. Front Genome Ed. 2020;2:9 pubmed publisher |
Di Franco S, Zhang L, Gaggianesi M, Lo Iacono M, Medema J, Stassi G. FACS-based protocol to assess cytotoxicity and clonogenic potential of colorectal cancer stem cells using a Wnt/β-catenin signaling pathway reporter. STAR Protoc. 2021;2:100880 pubmed publisher |
Ghuwalewala S, Ghatak D, Das S, Roy S, Das P, Butti R, et al. MiRNA-146a/AKT/β-Catenin Activation Regulates Cancer Stem Cell Phenotype in Oral Squamous Cell Carcinoma by Targeting CD24. Front Oncol. 2021;11:651692 pubmed publisher |
Chen Y, Zhang Z, Li X, Tao Y, Wu S, Fang F, et al. MI-773, a breaker of the MDM2/p53 axis, exhibits anticancer effects in neuroblastoma via downregulation of INSM1. Oncol Lett. 2021;22:838 pubmed publisher |
Zhao E, Mao A, de Puig H, Zhang K, Tippens N, Tan X, et al. RNA-responsive elements for eukaryotic translational control. Nat Biotechnol. 2021;: pubmed publisher |
Nofal M, Wang T, Yang L, Jankowski C, Hsin Jung Li S, Han S, et al. GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Syst. 2021;: pubmed publisher |
Symeonidou V, Jakobczyk H, Bashanfer S, Malouf C, Fotopoulou F, Kotecha R, et al. Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. Cell Rep. 2021;37:109900 pubmed publisher |
Yu C, Zhong H, Yang X, Li G, Wu Z, Yang H. Establishment of a pig CRISPR/Cas9 knockout library for functional gene screening in pig cells. Biotechnol J. 2021;:e2100408 pubmed publisher |
Czarnek M, Sarad K, Karaś A, Kochan J, Bereta J. Non-targeting control for MISSION shRNA library silences SNRPD3 leading to cell death or permanent growth arrest. Mol Ther Nucleic Acids. 2021;26:711-731 pubmed publisher |
Kim P, Niroula A, Shkolnik V, McConkey M, Lin A, Słabicki M, et al. Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. J Exp Med. 2021;218: pubmed publisher |
Brown A, Collins C, Thompson S, Coxon M, Mertz T, Roberts S. Single-stranded DNA binding proteins influence APOBEC3A substrate preference. Sci Rep. 2021;11:21008 pubmed publisher |
DeLuca J, Murphy M, Wang X, Wilson T. FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2. J Immunol. 2021;207:2688-2698 pubmed publisher |
Guo X, Kazanova A, Thurmond S, Saragovi H, Rudd C. Effective chimeric antigen receptor T cells against SARS-CoV-2. iScience. 2021;24:103295 pubmed publisher |
Liu Q, Tian R, Yu P, Shu M. miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells. FEBS Lett. 2021;595:2829-2843 pubmed publisher |
Basak I, Hansen R, Ward M, Hughes S. Deficiency of the Lysosomal Protein CLN5 Alters Lysosomal Function and Movement. Biomolecules. 2021;11: pubmed publisher |
Durdagi S, Avsar T, Orhan M, Serhatlı M, Balcioglu B, Ozturk H, et al. The neutralization effect of montelukaston SARS-CoV-2 is shown by multiscale in silicosimulations and combined in vitro studies. Mol Ther. 2021;: pubmed publisher |
Qian Z, Li H, Yang H, Yang Q, Lu Z, Wang L, et al. Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain. Sci Adv. 2021;7:eabi5811 pubmed publisher |
Buchl S, Hanquier Z, Haak A, Thomason Y, Huebert R, Shah V, et al. Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice. Hepatol Commun. 2021;: pubmed publisher |
Baek H, Kwon T, Shin S, Kwon Y, Chun Y. Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes. Sci Rep. 2021;11:20867 pubmed publisher |
Kitakaze K, Tsuboi K, Tsuda M, Takenouchi Y, Ishimaru H, Okamoto Y. Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7. J Lipid Res. 2021;62:100141 pubmed publisher |
Figueroa F, Vega Gibson A, Catrileo J, Gaete Argel A, Riquelme Barrios S, Alonso Palomares L, et al. N6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication. Front Cell Dev Biol. 2021;9:739445 pubmed publisher |
Zimmerman M, Durbin A, He S, Oppel F, Shi H, Tao T, et al. Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma. Sci Adv. 2021;7:eabe0834 pubmed publisher |
Zinshteyn B, Sinha N, Enam S, Koleske B, Green R. Translational repression of NMD targets by GIGYF2 and EIF4E2. PLoS Genet. 2021;17:e1009813 pubmed publisher |
Strash N, DeLuca S, Janer Carattini G, Heo S, Gorsuch R, Bursac N. Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes. elife. 2021;10: pubmed publisher |
Diesch J, Le Pannérer M, Winkler R, Casquero R, Muhar M, van der Garde M, et al. Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis. Nat Commun. 2021;12:6060 pubmed publisher |
Lin G, Li J, Cai J, Zhang H, Xin Q, Wang N, et al. RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway. J Cancer. 2021;12:6715-6726 pubmed publisher |
Carter Timofte M, Arulanandam R, Kurmasheva N, Fu K, Laroche G, Taha Z, et al. Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of Concern. ACS Infect Dis. 2021;7:3034-3051 pubmed publisher |
Junqueira Alves C, Dariolli R, Haydak J, Kang S, Hannah T, Wiener R, et al. Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion. Nat Commun. 2021;12:6019 pubmed publisher |
Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, et al. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Mol Cancer. 2021;20:132 pubmed publisher |
Saltari A, Dzung A, Quadri M, Tiso N, Facchinello N, Hernández Barranco A, et al. Specific Activation of the CD271 Intracellular Domain in Combination with Chemotherapy or Targeted Therapy Inhibits Melanoma Progression. Cancer Res. 2021;81:6044-6057 pubmed publisher |
Fukuda H, Chujo T, Wei F, Shi S, Hirayama M, Kaitsuka T, et al. Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Nucleic Acids Res. 2021;49:11855-11867 pubmed publisher |
Pan L, Hoffmeister P, Turkiewicz A, Huynh N, Große Berkenbusch A, Knippschild U, et al. Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Cancers (Basel). 2021;13: pubmed publisher |
Eisele B, Luka Z, Wu A, Yang F, Hale A, York J. Sulfation of glycosaminoglycans depends on the catalytic activity of lithium-inhibited phosphatase BPNT2 in vitro. J Biol Chem. 2021;297:101293 pubmed publisher |
Villiger L, Schmidheini L, Mathis N, Rothgangl T, Marquart K, Schwank G. Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope. Mol Ther Nucleic Acids. 2021;26:502-510 pubmed publisher |
Tang J, Chen Z, Wang Q, Hao W, Gao W, Xu H. hnRNPA2B1 Promotes Colon Cancer Progression via the MAPK Pathway. Front Genet. 2021;12:666451 pubmed publisher |
Bian W, Tang M, Jiang H, Xu W, Hao W, Sui Y, et al. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell. 2021;56:2902-2919.e8 pubmed publisher |
Uesugi R, Ishii S, Matsuura A, Itakura E. Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor. J Biol Chem. 2021;297:101279 pubmed publisher |
Xu H, George E, Kinose Y, Kim H, Shah J, Peake J, et al. CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med. 2021;2:100394 pubmed publisher |
Chen Z, Huang Y, Yu C, Liu Q, Qiu C, Wan G. Cochlear Sox2+ Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules. Front Cell Dev Biol. 2021;9:728352 pubmed publisher |
Zoladek J, Legros V, Jeannin P, Chazal M, Pardigon N, Ceccaldi P, et al. Zika Virus Requires the Expression of Claudin-7 for Optimal Replication in Human Endothelial Cells. Front Microbiol. 2021;12:746589 pubmed publisher |
Sun D, Evans L, Perrone F, Sokleva V, Lim K, Rezakhani S, et al. A functional genetic toolbox for human tissue-derived organoids. elife. 2021;10: pubmed publisher |
Covelo Molares H, Souto Y, Fidalgo M, Guallar D. A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells. Methods Mol Biol. 2021;: pubmed publisher |
Kittai A, Danilova O, Lam V, Liu T, Bruss N, Best S, et al. NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells. Oncotarget. 2021;12:2068-2074 pubmed publisher |
Angelini A, Saha P, Jain A, Jung S, Mynatt R, Pi X, et al. PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. Cell Rep. 2021;37:109767 pubmed publisher |
Becker R, Vergarajauregui S, Billing F, Sharkova M, Lippolis E, Mamchaoui K, et al. Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope. elife. 2021;10: pubmed publisher |
Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, et al. The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. J Biol Chem. 2021;297:101263 pubmed publisher |
Zhang Y, Huang Y, Jin X, Chen J, Peng L, Wang D, et al. Overexpression of lncRNAs with endogenous lengths and functions using a lncRNA delivery system based on transposon. J Nanobiotechnology. 2021;19:303 pubmed publisher |
Fenwick C, Turelli P, Perez L, Pellaton C, Esteves Leuenberger L, Farina A, et al. A highly potent antibody effective against SARS-CoV-2 variants of concern. Cell Rep. 2021;37:109814 pubmed publisher |
Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K. Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes. Biochem Biophys Res Commun. 2021;578:170-176 pubmed publisher |
Jayaram D, Frost S, Argov C, Liju V, Anto N, Muraleedharan A, et al. Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Okamoto Y, Kitakaze K, Takenouchi Y, Yamamoto S, Ishimaru H, Tsuboi K. Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation. Cell Signal. 2021;88:110156 pubmed publisher |
Sharma N, Wang C, Kessler P, Sen G. Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis. PLoS Pathog. 2021;17:e1009950 pubmed publisher |
Zhang D, Gui X, Yang X. Mapping Genetic Interactions in Human Cancer Cells Using a One-Step tRNA-CRISPR System. Methods Mol Biol. 2021;2381:175-187 pubmed publisher |
Oleszycka E, Rodgers A, Xu L, Moynagh P. Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. J Immunol. 2021;207:2325-2336 pubmed publisher |
Dogan K, Erol E, Didem Orhan M, Degirmenci Z, Kan T, Gungor A, et al. Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2. Phytochem Anal. 2021;: pubmed publisher |
Keum S, Yang S, Park E, Kang T, Choi J, Jeong J, et al. Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics. Cell Oncol (Dordr). 2021;44:1287-1305 pubmed publisher |
Li S, Li J, Liu J, Wang J, Li X, Huo Y, et al. Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression. Brain. 2021;: pubmed publisher |
Nguyen H, Wilson H, Jayakumar S, Kulkarni V, Kulkarni S. Efficient Inhibition of HIV Using CRISPR/Cas13d Nuclease System. Viruses. 2021;13: pubmed publisher |
Dos Santos M, Machado M, Kumaresan P, da Silva T. Titan Cells and Yeast Forms of Cryptococcus neoformans and Cryptococcus gattii Are Recognized by GXMR-CAR. Microorganisms. 2021;9: pubmed publisher |
Junyent S, Reeves J, Habib S. Assessing the Wnt-reactivity of cytonemes of mouse embryonic stem cells using a bioengineering approach. STAR Protoc. 2021;2:100813 pubmed publisher |
Romine K, Nechiporuk T, Bottomly D, Jeng S, McWeeney S, Kaempf A, et al. Monocytic differentiation and AHR signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia. Blood Cancer Discov. 2021;2:518-531 pubmed publisher |
Rocha H, Godet I, Kurtoglu F, Metzcar J, Konstantinopoulos K, Bhoyar S, et al. A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling. iScience. 2021;24:102935 pubmed publisher |
Secilmis M, Altun H, Pilic J, Erdogan Y, Cokluk Z, Ata B, et al. A Co-Culture-Based Multiparametric Imaging Technique to Dissect Local H2O2 Signals with Targeted HyPer7. Biosensors (Basel). 2021;11: pubmed publisher |
Zhao Y, Oreskovic E, Zhang Q, Lu Q, Gilman A, Lin Y, et al. Transposon-triggered innate immune response confers cancer resistance to the blind mole rat. Nat Immunol. 2021;22:1219-1230 pubmed publisher |
Song M, Lim J, Min S, Oh J, Kim D, Woo J, et al. Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain. Nat Commun. 2021;12:5617 pubmed publisher |
Sharma R, Choi K, Quan M, Sharma S, Sankaran B, Park H, et al. Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021;12:5579 pubmed publisher |
Kohela A, van Kampen S, Moens T, Wehrens M, Molenaar B, Boogerd C, et al. Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021;13:eabf2750 pubmed publisher |
Rauschendorfer T, Gurri S, Heggli I, Maddaluno L, Meyer M, Inglés Prieto A, et al. Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Life Sci Alliance. 2021;4: pubmed publisher |
Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, et al. ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model. Mol Metab. 2021;54:101338 pubmed publisher |
Wang Z, Chen J, Wu X, Ma D, Zhang X, Li R, et al. PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection. PLoS Pathog. 2021;17:e1009940 pubmed publisher |
Vandermeulen C, O Grady T, Wayet J, Galvan B, Maseko S, Cherkaoui M, et al. The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape. PLoS Pathog. 2021;17:e1009919 pubmed publisher |
Iqbal S, Luo B, Melamed J, Day E. Critical Evaluation of Different Lysosomal Labeling Methods Used to Analyze RNA Nanocarrier Trafficking in Cells. Bioconjug Chem. 2021;32:2245-2256 pubmed publisher |
Behrmann L, McComb S, Aguadé Gorgorió J, Huang Y, Hermann M, Pelczar P, et al. Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9. Bio Protoc. 2017;7:e2222 pubmed publisher |
He L, Huang Z, Huang K, Chen R, Nguyen N, Wang R, et al. Optogenetic Control of Non-Apoptotic Cell Death. Adv Sci (Weinh). 2021;8:2100424 pubmed publisher |
Jadav A, Truong K. Generation of stable cell lines using readthrough expression from lentiviral integration. Biotechnol Lett. 2021;43:2131-2136 pubmed publisher |
Li J, Ohmura S, Marchetto A, Orth M, Imle R, Dallmayer M, et al. Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. Nat Commun. 2021;12:5356 pubmed publisher |
An S, Rivera Molina F, Anneken A, Xi Z, McNellis B, Polejaev V, et al. An active tethering mechanism controls the fate of vesicles. Nat Commun. 2021;12:5434 pubmed publisher |
Cuevas Velazquez C, Vellosillo T, Guadalupe K, Schmidt H, Yu F, Moses D, et al. Intrinsically disordered protein biosensor tracks the physical-chemical effects of osmotic stress on cells. Nat Commun. 2021;12:5438 pubmed publisher |
Jaiswal A, Murakami K, Elia A, Shibahara Y, Done S, Wood S, et al. Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Shiozaki Y, Miyazaki Anzai S, Keenan A, Miyazaki M. MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis. Autophagy. 2021;:1-13 pubmed publisher |
Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter Pechanska P, et al. Virus-induced senescence is a driver and therapeutic target in COVID-19. Nature. 2021;599:283-289 pubmed publisher |
Castle E, Robinson C, Douglas P, Rinker K, Corcoran J. Viral Manipulation of a Mechanoresponsive Signaling Axis Disassembles Processing Bodies. Mol Cell Biol. 2021;41:e0039921 pubmed publisher |
Heden T, Chow L, Hughey C, Mashek D. Regulation and role of glycophagy in skeletal muscle energy metabolism. Autophagy. 2021;:1-12 pubmed publisher |
Nagamura Y, Miyazaki M, Nagano Y, Tomiyama A, Ohki R, Yanagihara K, et al. SHP2 as a Potential Therapeutic Target in Diffuse-Type Gastric Carcinoma Addicted to Receptor Tyrosine Kinase Signaling. Cancers (Basel). 2021;13: pubmed publisher |
Albano F, Tucci V, Blackshear P, Reale C, Roberto L, Russo F, et al. ZFP36L2 Role in Thyroid Functionality. Int J Mol Sci. 2021;22: pubmed publisher |
Yang Z, Yang M, Chow H, Tsang S, Lee M, Chan M. Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy. Acta Biomater. 2021;135:582-592 pubmed publisher |
Lin J, Liu H, Fukumoto T, Zundell J, Yan Q, Tang C, et al. Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Nat Commun. 2021;12:5321 pubmed publisher |
Quambusch L, Depta L, Landel I, Lubeck M, Kirschner T, Nabert J, et al. Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun. 2021;12:5297 pubmed publisher |
Xu C, Meng F, Park K, Storey A, Gong W, Tsai Y, et al. A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells. Cell Chem Biol. 2021;: pubmed publisher |
Parrish P, Thomas J, Gabel A, Kamlapurkar S, Bradley R, Berger A. Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome. Cell Rep. 2021;36:109597 pubmed publisher |
Miyazaki M, Hiramoto M, Takano N, Kokuba H, Takemura J, Tokuhisa M, et al. Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics. Int J Mol Med. 2021;48: pubmed publisher |
Müller T, Jarosch S, Hammel M, Leube J, Grassmann S, Bernard B, et al. Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy. Cell Rep Med. 2021;2:100374 pubmed publisher |
Redman Rivera L, Shaver T, Jin H, Marshall C, Schafer J, Sheng Q, et al. Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. Nat Commun. 2021;12:5184 pubmed publisher |
Buongervino S, Lane M, Garrigan E, Zhelev D, Dimitrov D, Bosse K. Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization. Mol Cancer Ther. 2021;20:2228-2239 pubmed publisher |
Saha P, Kim M, Tulshyan A, Guo Y, Mishra R, Li D, et al. Hypoxia-inducible factor 1-alpha enhances the secretome to rejuvenate adult cardiosphere-derived cells. J Thorac Cardiovasc Surg. 2021;: pubmed publisher |
Liu Y, Zhao N, Kanemaki M, Yamamoto Y, Sadamura Y, Ito Y, et al. Visualizing looping of two endogenous genomic loci using synthetic zinc-finger proteins with anti-FLAG and anti-HA frankenbodies in living cells. Genes Cells. 2021;26:905-926 pubmed publisher |
Hannes S, Karlowitz R, van Wijk S. The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells. Cell Death Dis. 2021;12:816 pubmed publisher |
Hu H, Khodadadi Jamayran A, Dolgalev I, Cho H, Badri S, Chiriboga L, et al. Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity. Cancer Immunol Res. 2021;9:1298-1315 pubmed publisher |
Liu J, Bodnar B, Meng F, Khan A, Wang X, Saribas S, et al. Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. Cell Biosci. 2021;11:168 pubmed publisher |
Zhang Y, He Y, Wu P, Hu S, Zhang Y, Chen C. miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1. Int J Stem Cells. 2021;14:423-433 pubmed publisher |
Benfatto S, Serçin O, Dejure F, Abdollahi A, Zenke F, Mardin B. Uncovering cancer vulnerabilities by machine learning prediction of synthetic lethality. Mol Cancer. 2021;20:111 pubmed publisher |
Ahn D, Yoon G, Lee S, Ku K, Kim C, Kim K, et al. A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses. Viruses. 2021;13: pubmed publisher |
Hölper J, Grey F, Baillie J, Regan T, Parkinson N, Höper D, et al. A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD-Pass. Viruses. 2021;13: pubmed publisher |
Díaz Tejeda Y, Guido Jimenez M, López Carbajal H, Amador Molina A, Méndez Martínez R, Gariglio Vidal P, et al. Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18. Viruses. 2021;13: pubmed publisher |
Janssen A, Korsten G, Nijenhuis W, Katrukha E, Kapitein L. Direct observation of aggregate-triggered selective autophagy in human cells. J Cell Sci. 2021;134: pubmed publisher |
Jang H, Jo D, Cho C, Shin J, Seo J, Yu G, et al. Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases. Nat Biomed Eng. 2021;: pubmed publisher |
Mariani L, Guo X, Menezes N, Drozd A, Çakal S, Wang Q, et al. A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm. Nat Commun. 2021;12:5136 pubmed publisher |
Mazurek S, Oleksiewicz U, Czerwińska P, Wroblewska J, Klimczak M, Wiznerowicz M. Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs. Cells. 2021;10: pubmed publisher |
Tang Q, Liu M, Liu Y, Hwang R, Zhang T, Wang J. NDST3 deacetylates α-tubulin and suppresses V-ATPase assembly and lysosomal acidification. EMBO J. 2021;40:e107204 pubmed publisher |
Marquart K, Allam A, Janjuha S, Sintsova A, Villiger L, Frey N, et al. Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens. Nat Commun. 2021;12:5114 pubmed publisher |
Voss G, Edsjö A, Bjartell A, Ceder Y. Quantification of microRNA editing using two-tailed RT-qPCR for improved biomarker discovery. RNA. 2021;27:1412-1424 pubmed publisher |
Ge X, Frank Bertoncelj M, Klein K, McGovern A, Kuret T, Houtman M, et al. Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability. Genome Biol. 2021;22:247 pubmed publisher |
Wu B, Woo J, Vila P, Jew M, Leung J, Sun Z, et al. NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells. Cell Rep. 2021;36:109603 pubmed publisher |
Siolas D, Vucic E, Kurz E, Hajdu C, Bar Sagi D. Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy. Cell Rep. 2021;36:109578 pubmed publisher |
Fei Q, Qiu M, Fan G, Zhang B, Wang Q, Zhang S, et al. Downregulation of Hotair or LSD1 Impaired Heart Regeneration in the Neonatal Mouse. DNA Cell Biol. 2021;40:1177-1184 pubmed publisher |
Guardia C, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino J. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell. 2021;32:ar25 pubmed publisher |
Nowak R, Yue H, Park E, Fischer E. Methods for Quantitative Assessment of Protein Degradation. Methods Mol Biol. 2021;2365:247-263 pubmed publisher |
Zhang K, Zhang Y, Maharjan Y, Sugiokto F, Wan J, Li R. Caspases Switch off the m6A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus. MBio. 2021;12:e0170621 pubmed publisher |
Cong L, Sugden S, Leclair P, Lim C, Pham T, Cohen E. HIV-1 Vpu Promotes Phagocytosis of Infected CD4+ T Cells by Macrophages through Downregulation of CD47. MBio. 2021;12:e0192021 pubmed publisher |
Yu C, Rao D, Zhu H, Liu Q, Huang W, Zhang L, et al. TDO2 Was Downregulated in Hepatocellular Carcinoma and Inhibited Cell Proliferation by Upregulating the Expression of p21 and p27. Biomed Res Int. 2021;2021:4708439 pubmed publisher |
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson M, Schmitz W, Wach S, et al. MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Nat Commun. 2021;12:5066 pubmed publisher |
Waybright J, Clinkscales S, Barnash K, Budziszewski G, Rectenwald J, Chiarella A, et al. A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex. ACS Chem Biol. 2021;16:1721-1736 pubmed publisher |
Francis C, Kushner E. Capturing membrane trafficking events during 3D angiogenic development in vitro. Microcirculation. 2021;:e12726 pubmed publisher |
Su X, Shen Y, Jin Y, Kim I, Weintraub N, Tang Y. Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice. Front Pharmacol. 2021;12:654316 pubmed publisher |
Feng L, Feng S, Nie Z, Deng Y, Xuan Y, Chen X, et al. TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIFα Pathway. Biomed Res Int. 2021;2021:3431245 pubmed publisher |
Chan D, Xu J, Vujovic A, Wong N, Gordon V, de Rooij L, et al. Arhgef2 regulates mitotic spindle orientation in hematopoietic stem cells and is essential for productive hematopoiesis. Blood Adv. 2021;5:3120-3133 pubmed publisher |
Ding J, Aldo P, Roberts C, Stabach P, Liu H, You Y, et al. Placenta-derived interferon-stimulated gene 20 controls ZIKA virus infection. EMBO Rep. 2021;22:e52450 pubmed publisher |
Marques C, Unterkircher T, Kroon P, Oldrini B, Izzo A, Dramaretska Y, et al. NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1. elife. 2021;10: pubmed publisher |
Yu W, Ma H, Li J, Ge J, Wang P, Zhou Y, et al. DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling. Cancer Cell Int. 2021;21:430 pubmed publisher |
Börold J, Eletto D, Busnadiego I, Mair N, Moritz E, Schiefer S, et al. BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity. EMBO Rep. 2021;22:e52823 pubmed publisher |
Mojiri A, Walther B, Jiang C, Matrone G, Holgate R, Xu Q, et al. Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice. Eur Heart J. 2021;42:4352-4369 pubmed publisher |
Lepelley A, Della Mina E, van Nieuwenhove E, Waumans L, Fraitag S, Rice G, et al. Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A. J Exp Med. 2021;218: pubmed publisher |
Peng K, Sun A, Zhu J, Gao J, Li Y, Shao G, et al. Restoration of the ATG5-dependent autophagy sensitizes DU145 prostate cancer cells to chemotherapeutic drugs. Oncol Lett. 2021;22:638 pubmed publisher |
Miller I, Zamat A, Sun L, Phuengkham H, Harris A, Gamboa L, et al. Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Nat Biomed Eng. 2021;5:1348-1359 pubmed publisher |
Parker S, Encarnación Rosado J, Hollinshead K, Hollinshead D, Ash L, Rossi J, et al. Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters. Nat Commun. 2021;12:4905 pubmed publisher |
Wu C, Hilgendorf K, Bevacqua R, Hang Y, Demeter J, Kim S, et al. Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Genes Dev. 2021;: pubmed publisher |
Shi S, Fukuda H, Chujo T, Kouwaki T, Oshiumi H, Tomizawa K, et al. Export of RNA-derived modified nucleosides by equilibrative nucleoside transporters defines the magnitude of autophagy response and Zika virus replication. RNA Biol. 2021;18:478-495 pubmed publisher |
Yuan J, Jiang Q, Gong T, Fan D, Zhang J, Chen F, et al. Loss of grand histone H3 lysine 27 trimethylation domains mediated transcriptional activation in esophageal squamous cell carcinoma. NPJ Genom Med. 2021;6:65 pubmed publisher |
Yuste Checa P, Trinkaus V, Riera Tur I, Imamoglu R, Schaller T, Wang H, et al. The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nat Commun. 2021;12:4863 pubmed publisher |
Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, et al. USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Nat Commun. 2021;12:4852 pubmed publisher |
Kremer D, Nelson B, Lin L, Yarosz E, Halbrook C, Kerk S, et al. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nat Commun. 2021;12:4860 pubmed publisher |
Ladha F, Thakar K, Pettinato A, Legere N, Ghahremani S, Cohn R, et al. Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Cell Rep. 2021;36:109512 pubmed publisher |
Quinn S, Huang L, Kerkvliet J, Swanson J, Smith S, Hoppe A, et al. The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy. Nat Commun. 2021;12:4838 pubmed publisher |
Vichas A, Riley A, Nkinsi N, Kamlapurkar S, Parrish P, Lo A, et al. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Nat Commun. 2021;12:4789 pubmed publisher |
Zhu Q, Ma Y, Liang J, Wei Z, Li M, Zhang Y, et al. AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma. Signal Transduct Target Ther. 2021;6:299 pubmed publisher |
Huang Y, Yang Q, Zheng Y, Lin L, Xu X, Xu X, et al. Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Nucleic Acids Res. 2021;: pubmed publisher |
Kannangara A, Poole D, McEwan C, Youngs J, Weerasekara V, Thornock A, et al. BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. EMBO Rep. 2021;:e51136 pubmed publisher |
Mnich K, Koryga I, Pakos Zebrucka K, Thomas M, Logue S, Eriksson L, et al. The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner. J Cell Mol Med. 2021;: pubmed publisher |
Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, et al. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021;24:102758 pubmed publisher |
Mellis I, Edelstein H, Truitt R, Goyal Y, Beck L, Symmons O, et al. Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Cell Syst. 2021;: pubmed publisher |
Nuebel E, Morgan J, Fogarty S, Winter J, Lettlova S, Berg J, et al. The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. EMBO Rep. 2021;:e51991 pubmed publisher |
Su H, Qin M, Liu Q, Jin B, Shi X, Xiang Z. Ubiquitin-Like Protein UBD Promotes Cell Proliferation in Colorectal Cancer by Facilitating p53 Degradation. Front Oncol. 2021;11:691347 pubmed publisher |
Li C, Zhang Y, Yan S, Zhang G, Wei W, Qi Z, et al. Alternol triggers immunogenic cell death via reactive oxygen species generation. Oncoimmunology. 2021;10:1952539 pubmed publisher |
Wang L, Rajah A, Brown C, McCaffrey L. CD13 orients the apical-basal polarity axis necessary for lumen formation. Nat Commun. 2021;12:4697 pubmed publisher |
Holzner S, Bromberger S, Wenzina J, Neumüller K, Holper T, Petzelbauer P, et al. Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells. J Cell Sci. 2021;: pubmed publisher |
Nagati J, Kobeissy P, Nguyen M, Xu M, Garcia T, Comerford S, et al. Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements. J Biol Chem. 2021;:101037 pubmed publisher |
Shaker M, Aguado J, Chaggar H, Wolvetang E. Klotho inhibits neuronal senescence in human brain organoids. NPJ Aging Mech Dis. 2021;7:18 pubmed publisher |
Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, et al. STING1 is essential for an RNA-virus triggered autophagy. Autophagy. 2021;:1-13 pubmed publisher |
Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed publisher |
Yang X, Wu G, Yang F, He L, Xie X, Li L, et al. Elevated LINC00909 Promotes Tumor Progression of Ovarian Cancer via Regulating the miR-23b-3p/MRC2 Axis. Oxid Med Cell Longev. 2021;2021:5574130 pubmed publisher |
Tao L, Yu H, Llamas J, Trecek T, Wang X, Stojanova Z, et al. Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration. Dev Cell. 2021;: pubmed publisher |
Giuliani V, Miller M, Liu C, Hartono S, Class C, Bristow C, et al. PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma. Nat Commun. 2021;12:4626 pubmed publisher |
Laliotis G, Chavdoula E, Paraskevopoulou M, Kaba A, La Ferlita A, Singh S, et al. AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Nat Commun. 2021;12:4624 pubmed publisher |
Song S, Manook M, Kwun J, Jackson A, Knechtle S, Kelsoe G. Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. Front Immunol. 2021;12:705140 pubmed publisher |
Yang J, Weisberg E, Liu X, Magin R, Chan W, Hu B, et al. Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2. Leukemia. 2021;: pubmed publisher |
Lu C, Liu Z, Klement J, Yang D, Merting A, Poschel D, et al. WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape. J Immunother Cancer. 2021;9: pubmed publisher |
Ghelman J, Grewing L, Windener F, Albrecht S, Zarbock A, Kuhlmann T. SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation. Glia. 2021;: pubmed publisher |
Neyrinck K, García León J. Single Transcription Factor-Based Differentiation Allowing Fast and Efficient Oligodendrocyte Generation via SOX10 Overexpression. Methods Mol Biol. 2021;2352:149-170 pubmed publisher |
Zhou Yang L, Eichhorner S, Karbacher L, Böhnke L, Traxler L, Mertens J. Direct Conversion of Human Fibroblasts to Induced Neurons. Methods Mol Biol. 2021;2352:73-96 pubmed publisher |
Nalairndran G, Chung I, Abdul Razack A, Chung F, Hii L, Lim W, et al. Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells. J Cell Mol Med. 2021;: pubmed publisher |
Liu Y, Sun H, Li X, Liu Q, Zhao Y, Li L, et al. Identification of a Three-RNA Binding Proteins (RBPs) Signature Predicting Prognosis for Breast Cancer. Front Oncol. 2021;11:663556 pubmed publisher |
Zhang Q, Agius S, Flanigan S, Uckelmann M, Levina V, Owen B, et al. PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nat Commun. 2021;12:4592 pubmed publisher |
Carullo N, Hinds J, Revanna J, Tuscher J, Bauman A, Day J. A Cre-dependent CRISPR/dCas9 system for gene expression regulation in neurons. Eneuro. 2021;: pubmed publisher |
Hussain S, Tran T, Ware T, Luse M, Prevost C, Ferguson A, et al. RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal. Cell Rep. 2021;36:109451 pubmed publisher |
Cabezudo S, Sanz Flores M, Caballero A, Tasset I, Rebollo E, Díaz A, et al. Gαq activation modulates autophagy by promoting mTORC1 signaling. Nat Commun. 2021;12:4540 pubmed publisher |
Yura Y, Miura Yura E, Katanasaka Y, Min K, Chavkin N, Polizio A, et al. The Cancer Therapy-Related Clonal Hematopoiesis Driver Gene Ppm1d Promotes Inflammation and Non-Ischemic Heart Failure in Mice. Circ Res. 2021;: pubmed publisher |
Challa S, Khulpateea B, Nandu T, Camacho C, Ryu K, Chen H, et al. Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers. Cell. 2021;: pubmed publisher |
Brandt M, Kim Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, et al. An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?. PLoS Genet. 2021;17:e1009684 pubmed publisher |
Tang A, Tang J, Miao Q, Zhu J, Guo H, Liu C, et al. Zinc finger antiviral protein (ZAP) inhibits small ruminant morbillivirus replication in vitro. Vet Microbiol. 2021;260:109163 pubmed publisher |
Peng J, Yi B, Wang M, Tan J, Huang Z. CRISPR/Cas9-Mediated Whole Genomic Wide Knockout Screening Identifies Specific Genes Associated With PM2.5-Induced Mineral Absorption in Liver Toxicity. Front Bioeng Biotechnol. 2021;9:669434 pubmed publisher |
He X, Ding L, Cao K, Peng H, Gu C, Li Y, et al. A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge. Emerg Microbes Infect. 2021;10:1555-1573 pubmed publisher |
Leysen S, Burnley R, Rodriguez E, Milroy L, Soini L, Adamski C, et al. A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1. J Mol Biol. 2021;433:167174 pubmed publisher |
Nishiga M, Qi L, Wu J. CRISPRi/a Screening with Human iPSCs. Methods Mol Biol. 2021;2320:261-281 pubmed publisher |
Sahu B, Pihlajamaa P, Zhang K, Palin K, Ahonen S, Cervera A, et al. Human cell transformation by combined lineage conversion and oncogene expression. Oncogene. 2021;: pubmed publisher |
Chiu Y, Medina C, Doyle C, Zhou M, Narahari A, Sandilos J, et al. Deacetylation as a receptor-regulated direct activation switch for pannexin channels. Nat Commun. 2021;12:4482 pubmed publisher |
Zhang W, Yang X, Chen L, Liu Y, Venkatarangan V, Reist L, et al. A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. PLoS Biol. 2021;19:e3001361 pubmed publisher |
Ning B, Huang Z, Youngquist B, Scott J, Niu A, Bojanowski C, et al. Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma. Nat Nanotechnol. 2021;: pubmed publisher |
Suzuki G, Saito Y, Seki M, Evans Yamamoto D, Negishi M, Kakoi K, et al. Machine learning approach for discrimination of genotypes based on bright-field cellular images. NPJ Syst Biol Appl. 2021;7:31 pubmed publisher |
Shi X, Jiang Y, Kitano A, Hu T, Murdaugh R, Li Y, et al. Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Sci Adv. 2021;7: pubmed publisher |
Wei G, Zhang Y, Zhao H, Wang Y, Liu Y, Liang B, et al. CD19/CD22 Dual-Targeted CAR T-cell Therapy for Relapsed/Refractory Aggressive B-cell Lymphoma: A Safety and Efficacy Study. Cancer Immunol Res. 2021;9:1061-1070 pubmed publisher |
Neises J, Hossain M, Sultana R, Wanniarachchi K, Wollman J, Nelson E, et al. Seroprevalence of SARS-CoV-2 antibodies among rural healthcare workers. J Med Virol. 2021;: pubmed publisher |
Han J, Heo K, Myung C. CIAPIN1 accelerates vascular remodelling via p53 and JAK2-STAT3 regulation in vascular smooth muscle cells. Br J Pharmacol. 2021;: pubmed publisher |
Wu Y, Gu W, Han X, Jin Z. LncRNA PVT1 promotes the progression of ovarian cancer by activating TGF-β pathway via miR-148a-3p/AGO1 axis. J Cell Mol Med. 2021;: pubmed publisher |
Linda K, Lewerissa E, Verboven A, Gabriele M, Frega M, Klein Gunnewiek T, et al. Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Autophagy. 2021;:1-20 pubmed publisher |
Khoyratty T, Ai Z, Ballesteros I, Eames H, Mathie S, Martín Salamanca S, et al. Distinct transcription factor networks control neutrophil-driven inflammation. Nat Immunol. 2021;: pubmed publisher |
Butler M, van Ingen Schenau D, Yu J, Jenni S, Dobay M, Hagelaar R, et al. BTK inhibition sensitizes Acute Lymphoblastic Leukemia to asparaginase by suppressing the Amino Acid Response pathway. Blood. 2021;: pubmed publisher |
Nowak R, Xiong Y, Kirmani N, Kalabathula J, Donovan K, Eleuteri N, et al. Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. J Med Chem. 2021;64:11637-11650 pubmed publisher |
Eidell K, LOVY A, Sylvain N, Scangarello F, Muendlein H, Ophir M, et al. LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors. J Cell Sci. 2021;: pubmed publisher |
De Groof T, Bergkamp N, Heukers R, Giap T, Bebelman M, Goeij de Haas R, et al. Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies. Nat Commun. 2021;12:4357 pubmed publisher |
Liu S, Fu S, Wang G, Cao Y, Li L, Li X, et al. Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease. Cell Metab. 2021;: pubmed publisher |
Shukla N, Roelle S, Suzart V, Bruchez A, Matreyek K. Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection. PLoS Pathog. 2021;17:e1009715 pubmed publisher |
He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, et al. Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. Cancer Commun (Lond). 2021;41:726-746 pubmed publisher |
Jian X, Felsenfeld G. Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Nat Commun. 2021;12:4338 pubmed publisher |
Liang L, Gu W, Li M, Gao R, Zhang X, Guo C, et al. The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18. Cell Death Dis. 2021;12:702 pubmed publisher |
Kaseke C, Park R, Singh N, Koundakjian D, Bashirova A, Garcia Beltran W, et al. HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV. Cell Rep. 2021;36:109378 pubmed publisher |
Jia L, Wang Y, Wang C. circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation. Adv Sci (Weinh). 2021;8:2003376 pubmed publisher |
Ghatak D, Datta A, Roychowdhury T, Chattopadhyay S, Roychoudhury S. MicroRNA-324-5p-CUEDC2 Axis Mediates Gain-of-Function Mutant p53-Driven Cancer Stemness. Mol Cancer Res. 2021;: pubmed publisher |
Garcillán B, Fuentes P, Marin A, Megino R, Chacon Arguedas D, Mazariegos M, et al. CD3G or CD3D Knockdown in Mature, but Not Immature, T Lymphocytes Similarly Cripples the Human TCRαβ Complex. Front Cell Dev Biol. 2021;9:608490 pubmed publisher |
Shen H, Li J, Heisler Taylor T, Makin R, Yang H, Mavlyutov T, et al. TMEM97 ablation aggravates oxidant-induced retinal degeneration. Cell Signal. 2021;86:110078 pubmed publisher |
Riscal R, Bull C, Mesaros C, Finan J, Carens M, Ho E, et al. Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma. Cancer Discov. 2021;: pubmed publisher |
Bourgeois J, Wang L, Rabino A, Everitt J, Alvarez M, Awadia S, et al. ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. PLoS Pathog. 2021;17:e1009713 pubmed publisher |
Tang X, Ruan H, Dong L, Li S, Wu Z, Guan M. lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression. Gastroenterol Res Pract. 2021;2021:5960821 pubmed publisher |
Saiada F, Zhang K, Li R. PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation. Cell Biosci. 2021;11:127 pubmed publisher |
Cuevas Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Curr Biol. 2021;: pubmed publisher |
Guo Y, Hinchman M, Lewandrowski M, Cross S, Sutherland D, Welsh O, et al. The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. PLoS Pathog. 2021;17:e1009494 pubmed publisher |
Kharin L, Bychkov I, Karnaukhov N, Voloshin M, Fazliyeva R, Deneka A, et al. Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression. PLoS ONE. 2021;16:e0252132 pubmed publisher |
Fu G, Guy C, Chapman N, Palacios G, Wei J, Zhou P, et al. Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine. Nature. 2021;595:724-729 pubmed publisher |
Tang W, Weng L, Wang X, Liu C, Hu G, Yin S, et al. The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Cell Rep. 2021;36:109314 pubmed publisher |
Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, et al. Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. Mol Cell. 2021;81:3110-3127.e14 pubmed publisher |
Havlik L, Das A, Mietzsch M, Oh D, Ark J, McKenna R, et al. Receptor switching in newly evolved adeno-associated viruses. J Virol. 2021;:JVI0058721 pubmed publisher |
Doubleday P, Fornelli L, Ntai I, Kelleher N. Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells. FEBS J. 2021;288:6683-6699 pubmed publisher |
Conde Rubio M, Mylonas R, Widmann C. The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases. Cell Death Discov. 2021;7:164 pubmed publisher |
Li P, Jiang H, Peng H, Zeng W, Zhong Y, He M, et al. Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis. Virol Sin. 2021;: pubmed publisher |
Beziat V, Rapaport F, Hu J, Titeux M, Bonnet des Claustres M, Bourgey M, et al. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell. 2021;184:3812-3828.e30 pubmed publisher |
Puray Chavez M, Lapak K, Schrank T, Elliott J, Bhatt D, Agajanian M, et al. Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell. Cell Rep. 2021;36:109364 pubmed publisher |
Zhao Y, He W, Zhao Z, Li W, Wang Q, Hou Y, et al. Acidic pH irreversibly activates the signaling enzyme SARM1. FEBS J. 2021;: pubmed publisher |
Sampaio N, Chauveau L, Hertzog J, Bridgeman A, Fowler G, Moonen J, et al. The RNA sensor MDA5 detects SARS-CoV-2 infection. Sci Rep. 2021;11:13638 pubmed publisher |
Ilmjärv S, Abdul F, Acosta Gutiérrez S, Estarellas C, Galdadas I, Casimir M, et al. Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant. Sci Rep. 2021;11:13705 pubmed publisher |
Yoo Y, Park S, Jo E, Choi M, Lee K, Hong D, et al. Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness. Cancers (Basel). 2021;13: pubmed publisher |
Barrado Gil L, del Puerto A, Galindo I, Cuesta Geijo M, Garcia Dorival I, de Motes C, et al. African Swine Fever Virus Ubiquitin-Conjugating Enzyme Is an Immunomodulator Targeting NF-κB Activation. Viruses. 2021;13: pubmed publisher |
Lejeune M, Duray E, Peipp M, Clémenceau B, Baron F, Beguin Y, et al. Balancing the CD38 Expression on Effector and Target Cells in Daratumumab-Mediated NK Cell ADCC against Multiple Myeloma. Cancers (Basel). 2021;13: pubmed publisher |
Ko P, Choi J, Song S, Keum S, Jeong J, Hwang Y, et al. Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress. Int J Mol Sci. 2021;22: pubmed publisher |
Li N, Torres M, Spetz M, Wang R, Peng L, Tian M, et al. CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. Cell Rep Med. 2021;2:100297 pubmed publisher |
Niederschweiberer M, Schaefer P, Singh L, Lausser L, Bhosale D, Hesse R, et al. NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer's Disease-Related Proteins. Front Mol Biosci. 2021;8:671274 pubmed publisher |
Yang F, Tanasa B, Micheletti R, Ohgi K, Aggarwal A, Rosenfeld M. Shape of promoter antisense RNAs regulates ligand-induced transcription activation. Nature. 2021;595:444-449 pubmed publisher |
Kuzuoğlu Öztürk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang G, et al. Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Rep. 2021;35:109321 pubmed publisher |
Watson A, Grant A, Parker S, Hill S, Whalen M, Chakrabarti J, et al. Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning. Cell Rep. 2021;35:109293 pubmed publisher |
York S, Sun L, Cone A, Duke L, Cheerathodi M, Meckes D. Zika Virus Hijacks Extracellular Vesicle Tetraspanin Pathways for Cell-to-Cell Transmission. mSphere. 2021;:e0019221 pubmed publisher |
Enderle L, Shalaby K, Gorelik M, Weiss A, Blazer L, Paduch M, et al. A T cell redirection platform for co-targeting dual antigens on solid tumors. MAbs. 2021;13:1933690 pubmed publisher |
Meier Abt F, Lu J, Cannizzaro E, Pohly M, Kummer S, Pfammatter S, et al. The Protein Landscape of Chronic Lymphocytic Leukemia (CLL). Blood. 2021;: pubmed publisher |
Troyer Z, Alhusaini N, Tabler C, Sweet T, de Carvalho K, Schlatzer D, et al. Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies. J Extracell Vesicles. 2021;10:e12112 pubmed publisher |
Taïeb H, Garske D, Contzen J, Gossen M, Bertinetti L, Robinson T, et al. Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells. Sci Rep. 2021;11:13455 pubmed publisher |
Zhang F, Yang Y, Chen X, Liu Y, Hu Q, Huang B, et al. The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice. Nat Commun. 2021;12:3997 pubmed publisher |
Xia Z, Tang M, Ma J, Zhang H, Gimple R, Prager B, et al. Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase. Nucleic Acids Res. 2021;49:7361-7374 pubmed publisher |
Ramirez Alvarez C, Kee C, Sharma A, Thomas L, Schmidt F, Stanifer M, et al. The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. PLoS Pathog. 2021;17:e1009687 pubmed publisher |
Chow H, Sun J, Hart R, Cheng K, Hung C, Lau T, et al. Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes. Adv Sci (Weinh). 2021;:e2004993 pubmed publisher |
Perez García V, Lea G, Lopez Jimenez P, Okkenhaug H, Burton G, Moffett A, et al. BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion. elife. 2021;10: pubmed publisher |
Peng Z, Yu M, Lin J, Dong T, Zhang X, Shi M, et al. Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response. STAR Protoc. 2021;2:100595 pubmed publisher |
Di Franco S, Parrino B, Gaggianesi M, Pantina V, Bianca P, Nicotra A, et al. CHK1 inhibitor sensitizes resistant colorectal cancer stem cells to nortopsentin. iScience. 2021;24:102664 pubmed publisher |
Wang W, Xia X, Chen K, Chen M, Meng Y, Lv D, et al. Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling. Front Oncol. 2021;11:665045 pubmed publisher |
Wellner A, McMahon C, Gilman M, Clements J, Clark S, Nguyen K, et al. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021;: pubmed publisher |
Gupte R, Nandu T, Kraus W. Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages. Nat Commun. 2021;12:3931 pubmed publisher |
Wang X, Wang H, Hu G, Tang W, Weng L, Zhang Y, et al. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Cell Rep. 2021;35:109281 pubmed publisher |
Morelli E, Gullà A, Amodio N, Taiana E, Neri A, Fulciniti M, et al. CRISPR Interference (CRISPRi) and CRISPR Activation (CRISPRa) to Explore the Oncogenic lncRNA Network. Methods Mol Biol. 2021;2348:189-204 pubmed publisher |
Liu M, Klement J, Langan C, van Riggelen J, Liu K. Expression regulation and function of PD-1 and PD-L1 in T lymphoma cells. Cell Immunol. 2021;366:104397 pubmed publisher |
Onuma K, Sato Y, Okuyama H, Uematsu H, Homma K, Ohue M, et al. Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma. J Pathol. 2021;255:84-94 pubmed publisher |
Deng G, Li C, Chen L, Xing C, Fu C, Qian C, et al. BECN2 (beclin 2) Negatively Regulates Inflammasome Sensors Through ATG9A-Dependent but ATG16L1- and LC3-Independent Non-Canonical Autophagy. Autophagy. 2021;:1-17 pubmed publisher |
Xie X, Zhou Z, Song Y, Zhang X, Dang C, Zhang H. Mist1 Inhibits Epithelial-Mesenchymal Transition in Gastric Adenocarcinoma via Downregulating the Wnt/β-catenin Pathway. J Cancer. 2021;12:4574-4584 pubmed publisher |
Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, et al. ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nat Cancer. 2021;2:503-514 pubmed publisher |
Debackere K, Marcelis L, Demeyer S, Vanden Bempt M, Mentens N, Gielen O, et al. Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified. Nat Commun. 2021;12:3705 pubmed publisher |
Wan C, Mahara S, Sun C, Doan A, Chua H, Xu D, et al. Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer. Sci Adv. 2021;7: pubmed publisher |
Huang S, Liao W, Hsu C, Chan T, Liao T, Yang P, et al. A Novel Invadopodia-Specific Marker for Invasive and Pro-Metastatic Cancer Stem Cells. Front Oncol. 2021;11:638311 pubmed publisher |
Russell K, Downie J, Gibson S, Tsetsou S, Keefe M, Duran J, et al. Pathogenic effect of TP73 Gene Variants in People With Amyotrophic Lateral Sclerosis. Neurology. 2021;: pubmed publisher |
Du Y, Wang J, Xiong J, Fang N, Ji W. VPS13D interacts with VCP/p97 and negatively regulates endoplasmic reticulum-mitochondria interactions. Mol Biol Cell. 2021;32:1474-1486 pubmed publisher |
Das S, Chadwick B. CRISPR mediated targeting of DUX4 distal regulatory element represses DUX4 target genes dysregulated in Facioscapulohumeral muscular dystrophy. Sci Rep. 2021;11:12598 pubmed publisher |
Sun L, Meckes D. Multiplex protein profiling method for extracellular vesicle protein detection. Sci Rep. 2021;11:12477 pubmed publisher |
Chen S, Zhang J, Shen M, Han X, Li S, Hu C, et al. p38 inhibition enhances TCR-T cell function and antagonizes the immunosuppressive activity of TGF-β. Int Immunopharmacol. 2021;98:107848 pubmed publisher |
Wu W, Qu Y, Yu S, Wang S, Yin Y, Liu Q, et al. Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity. MBio. 2021;12:e0100521 pubmed publisher |
Münzer P, Negro R, Fukui S, Di Meglio L, Aymonnier K, Chu L, et al. NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Front Immunol. 2021;12:683803 pubmed publisher |
Inoue Y, Nikolic A, Farnsworth D, Shi R, Johnson F, Liu A, et al. Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer. elife. 2021;10: pubmed publisher |
Wu T, Nguyen H, Bursac N. In vitro discovery of novel prokaryotic ion channel candidates for antiarrhythmic gene therapy. Methods Enzymol. 2021;654:407-434 pubmed publisher |
Tan L, Cheng W, Liu F, Wang D, Wu L, Cao N, et al. Positive natural selection of N6-methyladenosine on the RNAs of processed pseudogenes. Genome Biol. 2021;22:180 pubmed publisher |
Yu X, Zhang X, Xu J, Guo P, Li X, Wang H, et al. Generation of recombinant antibodies by mammalian expression system for detecting S-metolachlor in environmental waters. J Hazard Mater. 2021;418:126305 pubmed publisher |
Salloum S, Jeyarajan A, Kruger A, Holmes J, Shao T, Sojoodi M, et al. Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase. Cell Mol Gastroenterol Hepatol. 2021;: pubmed publisher |
Ochi K, Morita M, Wilkinson A, Iwama A, Yamazaki S. Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells. Nat Commun. 2021;12:3568 pubmed publisher |
Yan L, Tu B, Yao J, Gong J, Carugo A, Bristow C, et al. Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition. Cancer Res. 2021;81:4054-4065 pubmed publisher |
Kodama Y, Tanaka I, Sato T, Hori K, Gen S, Morise M, et al. Oxytocin receptor is a promising therapeutic target of malignant mesothelioma. Cancer Sci. 2021;112:3520-3532 pubmed publisher |
Mazor G, Smirnov D, Ben David H, Khrameeva E, Toiber D, Rotblat B. TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain. Aging (Albany NY). 2021;13:14843-14861 pubmed publisher |
Garcia Garcia S, Rodrigo Faus M, Fonseca N, Manzano S, Gyorffy B, Ocana A, et al. HGK promotes metastatic dissemination in prostate cancer. Sci Rep. 2021;11:12287 pubmed publisher |
Elguindy M, Mendell J. NORAD-induced Pumilio phase separation is required for genome stability. Nature. 2021;595:303-308 pubmed publisher |
Takahashi K, Niki T, Ogawa E, Fumika K, Nishioka Y, Sawa M, et al. A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation. Sci Rep. 2021;11:11996 pubmed publisher |
Janmaat V, Nesteruk K, Spaander M, Verhaar A, Yu B, Silva R, et al. HOXA13 in etiology and oncogenic potential of Barrett's esophagus. Nat Commun. 2021;12:3354 pubmed publisher |
Gutmann C, Takov K, Burnap S, Singh B, Ali H, Theofilatos K, et al. SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care. Nat Commun. 2021;12:3406 pubmed publisher |
Liang F, Wang B, Geng J, You G, Fa J, Zhang M, et al. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. elife. 2021;10: pubmed publisher |
Nodari A, Scambi I, Peroni D, Calabria E, Benati D, Mannucci S, et al. Interferon regulatory factor 7 impairs cellular metabolism in aging adipose-derived stromal cells. J Cell Sci. 2021;134: pubmed publisher |
Chen K, Oztürk K, Liefeld T, Reich M, Mesirov J, Carter H, et al. A phenotypically supervised single-cell analysis protocol to study within-cell-type heterogeneity of cultured mammalian cells. STAR Protoc. 2021;2:100561 pubmed publisher |
Zhou Z, Ma L, Zhang X. Protocol for genome-scale CRISPR screening in engineered lineage reporter hPSCs to study cell fate determination. STAR Protoc. 2021;2:100548 pubmed publisher |
Zheng Z, Hong D, Zhang X, Chang Y, Sun N, Lin Z, et al. uc.77- Downregulation Promotes Colorectal Cancer Cell Proliferation by Inhibiting FBXW8-Mediated CDK4 Protein Degradation. Front Oncol. 2021;11:673223 pubmed publisher |
Daks A, Petukhov A, Fedorova O, Shuvalov O, Kizenko A, Tananykina E, et al. The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase. Cell Death Dis. 2021;12:581 pubmed publisher |
Lim A, Vincent B, Weaver A, Rathmell W. Sunitinib and Axitinib increase secretion and glycolytic activity of small extracellular vesicles in renal cell carcinoma. Cancer Gene Ther. 2021;: pubmed publisher |
Liu J, Hideshima T, Xing L, Wang S, Zhou W, Samur M, et al. ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment. Sci Adv. 2021;7: pubmed publisher |
Huang N, Li S, Xie Y, Han Q, Xu X, Sheng Z. Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia. Curr Biol. 2021;31:3098-3114.e7 pubmed publisher |
Truong D, Phlairaharn T, Eßwein B, Gruber C, Tümen D, Baligács E, et al. Non-invasive and high-throughput interrogation of exon-specific isoform expression. Nat Cell Biol. 2021;23:652-663 pubmed publisher |
Luo J, Zou H, Li P. Src-Yap1 signaling axis controls the trophectoderm and epiblast lineage differentiation in mouse embryonic stem cells. Stem Cell Res. 2021;54:102413 pubmed publisher |
Miroshnikova Y, Manet S, Li X, Wickström S, Faurobert E, Albiges Rizo C. Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch. Mol Biol Cell. 2021;:mbcE21030106 pubmed publisher |
Chen S, Chen Y, Wen Y, Cai W, Zhu P, Yuan W, et al. miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines. Oncol Lett. 2021;22:532 pubmed publisher |
Thomson C, Pundavela J, Perrino M, Coover R, Choi K, Chaney K, et al. WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Oncogene. 2021;40:4229-4241 pubmed publisher |
Hamilton J, Tsuchida C, Nguyen D, Shy B, McGarrigle E, Sandoval Espinoza C, et al. Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering. Cell Rep. 2021;35:109207 pubmed publisher |
Qiao C, Huang W, Chen J, Feng W, Zhang T, Wang Y, et al. IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R. Cell Death Dis. 2021;12:564 pubmed publisher |
Martens M, Edelkamp J, Seebode C, Schäfer M, Stählke S, Krohn S, et al. Generation and Characterization of a CRISPR/Cas9-Mediated SNAP29 Knockout in Human Fibroblasts. Int J Mol Sci. 2021;22: pubmed publisher |
Fittipaldi R, Floris P, Proserpio V, Cotelli F, Beltrame M, Caretti G. The Lysine Methylase SMYD3 Modulates Mesendodermal Commitment during Development. Cells. 2021;10: pubmed publisher |
Wei T, Choi S, Buehler D, Lee D, Ward Shaw E, Anderson R, et al. Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis. Cancers (Basel). 2021;13: pubmed publisher |
Yang Y, Yang P, Huang C, Wu Y, Zhou Z, Wang X, et al. Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca2+ -dependent membrane fusion. J Med Virol. 2021;93:5825-5832 pubmed publisher |
Popp A, Hettich J, Gebhardt J. Altering transcription factor binding reveals comprehensive transcriptional kinetics of a basic gene. Nucleic Acids Res. 2021;49:6249-6266 pubmed publisher |
Kim C, Jin J, Ye Z, Jadhav R, Gustafson C, Hu B, et al. Histone deficiency and accelerated replication stress in T cell aging. J Clin Invest. 2021;131: pubmed publisher |
Ramaker R, Hardigan A, Gordon E, Wright C, Myers R, Cooper S. Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition. BMC Cancer. 2021;21:632 pubmed publisher |
Mahjoor M, Afkhami H, Mollaei M, Nasr A, Shahriary S, Khorrami S. MicroRNA-30c delivered by bone marrow-mesenchymal stem cells induced apoptosis and diminished cell invasion in U-251 glioblastoma cell line. Life Sci. 2021;279:119643 pubmed publisher |
Lu Q, Liu J, Zhao S, Gomez Castro M, Laurent Rolle M, Dong J, et al. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity. 2021;54:1304-1319.e9 pubmed publisher |
Yoon H, Lee H, Min J, Kim J, Park J, Kim J, et al. Optimal Ratio of Wnt3a Expression in Human Mesenchymal Stem Cells Promotes Axonal Regeneration in Spinal Cord Injured Rat Model. J Korean Neurosurg Soc. 2021;: pubmed publisher |
La Montagna M, Shi L, Magee P, Sahoo S, Fassan M, Garofalo M. AMPKα loss promotes KRAS-mediated lung tumorigenesis. Cell Death Differ. 2021;: pubmed publisher |
Kuramoto K, Kim Y, Hong J, He C. The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding. Cell Rep. 2021;35:109184 pubmed publisher |
Rothamel K, Arcos S, Kim B, Reasoner C, Lisy S, Mukherjee N, et al. ELAVL1 primarily couples mRNA stability with the 3' UTRs of interferon-stimulated genes. Cell Rep. 2021;35:109178 pubmed publisher |
Sacchetti A, Teeuwssen M, Verhagen M, Joosten R, Xu T, Stabile R, et al. Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. elife. 2021;10: pubmed publisher |
Vaz S, Ferreira F, Macedo J, Leor G, Ben David U, Bessa J, et al. FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell Death Dis. 2021;12:542 pubmed publisher |
Chen S, Miao B, Chen N, Chen C, Shao T, Zhang X, et al. SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation. Vet Res. 2021;52:73 pubmed publisher |
Timblin G, Tharp K, Ford B, Winchester J, Wang J, Zhu S, et al. Mitohormesis reprogrammes macrophage metabolism to enforce tolerance. Nat Metab. 2021;3:618-635 pubmed publisher |
Passini F, Jaeger P, Saab A, Hanlon S, Chittim N, Arlt M, et al. Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans. Nat Biomed Eng. 2021;: pubmed publisher |
Ghosh M, Kelava T, Madunić I, Kalajzic I, Shapiro L. CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis. Sci Rep. 2021;11:10736 pubmed publisher |
Dai M, Yan G, Wang N, Daliah G, Edick A, Poulet S, et al. In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Nat Commun. 2021;12:3055 pubmed publisher |
Muller I, Moroni A, Shlyueva D, Sahadevan S, Schoof E, Radzisheuskaya A, et al. MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Nat Commun. 2021;12:3034 pubmed publisher |
Morandell J, Schwarz L, Basilico B, Tasciyan S, Dimchev G, Nicolas A, et al. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. Nat Commun. 2021;12:3058 pubmed publisher |
Lin C, Tsai M, Chen Y, Liu W, Lin C, Hsu K, et al. Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo. Biomol Ther (Seoul). 2021;29:551-561 pubmed publisher |
Nazitto R, Amon L, Mast F, Aitchison J, Aderem A, Johnson J, et al. ILF3 Is a Negative Transcriptional Regulator of Innate Immune Responses and Myeloid Dendritic Cell Maturation. J Immunol. 2021;: pubmed publisher |
Eichberg D, Slepak T, Pascoini A, Komotar R, Ivan M. Genetic manipulation of adhesion GPCR CD97/ADGRE5 modulates invasion in patient-derived glioma stem cells. J Neurooncol. 2021;153:383-391 pubmed publisher |
Renneville A, Gasser J, Grinshpun D, Jean Beltran P, Udeshi N, Matyskiela M, et al. Avadomide induces degradation of ZMYM2 fusion oncoproteins in hematologic malignancies. Blood Cancer Discov. 2021;2:250-265 pubmed publisher |
Ross E, Ten Hoeve A, Barragan A. Integrin-dependent migratory switches regulate the translocation of Toxoplasma-infected dendritic cells across brain endothelial monolayers. Cell Mol Life Sci. 2021;78:5197-5212 pubmed publisher |
Ketkar H, Harrison A, Graziano V, Geng T, Yang L, Vella A, et al. UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. J Immunol. 2021;206:2682-2691 pubmed publisher |
Ury B, Potelle S, Caligiore F, Whorton M, Bommer G. The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. J Biol Chem. 2021;296:100789 pubmed publisher |
Zhang J, Zhou B, Sun R, Ai Y, Cheng K, Li F, et al. The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Res. 2021;: pubmed publisher |
Ordonez A, Harding H, Marciniak S, Ron D. Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers. Cell Rep. 2021;35:109144 pubmed publisher |
Okubo K, Brenner M, Cullere X, Saggu G, Patchen M, Bose N, et al. Inhibitory affinity modulation of FcγRIIA ligand binding by glycosphingolipids by inside-out signaling. Cell Rep. 2021;35:109142 pubmed publisher |
Zhao Y, Jiang S, Zhang J, Guan X, Sun B, Sun L. A virulent Bacillus cereus strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture. Virulence. 2021;12:1362-1376 pubmed publisher |
Koscielny A, Liszewska E, Machnicka K, Wezyk M, Kotulska K, Jaworski J. mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types. Cell Mol Biol Lett. 2021;26:18 pubmed publisher |
Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, et al. Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. EMBO Mol Med. 2021;13:e13074 pubmed publisher |
Liu W, Zhan Z, Zhang M, Sun B, Shi Q, Luo F, et al. KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1. Theranostics. 2021;11:6278-6292 pubmed publisher |
Vicioso Y, Wong D, Roy N, Das N, Zhang K, Ramakrishnan P, et al. NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells. Front Immunol. 2021;12:652786 pubmed publisher |
Hu X, Jiao F, Zhang L, Jiang Y. Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway. Front Pharmacol. 2021;12:654986 pubmed publisher |
Boleij A, Fathi P, Dalton W, PARK B, Wu X, Huso D, et al. G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Commun Biol. 2021;4:585 pubmed publisher |
Teufel S, Köckemann P, Fabritius C, Wolff L, Bertrand J, Pap T, et al. Loss of the WNT9a ligand aggravates the rheumatoid arthritis-like symptoms in hTNF transgenic mice. Cell Death Dis. 2021;12:494 pubmed publisher |
Ana Choi S, Ko J, Yu V, Ning L, Lung M. Differentiation-related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma. Oncol Lett. 2021;22:513 pubmed publisher |
Wang P, Gong S, Pan J, Wang J, Zou D, Xiong S, et al. Hyperbaric oxygen promotes not only glioblastoma proliferation but also chemosensitization by inhibiting HIF1α/HIF2α-Sox2. Cell Death Discov. 2021;7:103 pubmed publisher |
Neyrinck K, Van den Daele J, Vervliet T, De Smedt J, Wierda K, Nijs M, et al. SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System. Stem Cell Rev Rep. 2021;: pubmed publisher |
Sauer M, Tortorici M, Park Y, Walls A, Homad L, Acton O, et al. Structural basis for broad coronavirus neutralization. Nat Struct Mol Biol. 2021;28:478-486 pubmed publisher |
Yin Z, Chen W, Yin J, Sun J, Xie Q, Wu M, et al. RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis. NPJ Breast Cancer. 2021;7:53 pubmed publisher |
de Mingo Pulido Á, Hänggi K, Celias D, Gardner A, Li J, Batista Bittencourt B, et al. The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake. Immunity. 2021;54:1154-1167.e7 pubmed publisher |
Budagyan K, Chernoff J. A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background. Methods Mol Biol. 2021;2262:323-334 pubmed publisher |
Qiu R, Wu J, Gudenas B, Northcott P, Wechsler Reya R, Lu Q. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Commun Biol. 2021;4:552 pubmed publisher |
Choi S, Matta H, Gopalakrishnan R, Natarajan V, Gong S, Jeronimo A, et al. A novel thermostable beetle luciferase based cytotoxicity assay. Sci Rep. 2021;11:10002 pubmed publisher |
Li K, Girardi E, Kartnig F, Grosche S, Pemovska T, Bigenzahn J, et al. Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states. Nat Metab. 2021;3:651-664 pubmed publisher |
Koch A, Jeiler B, Roedig J, van Wijk S, Dolgikh N, Fulda S. Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines. Neoplasia. 2021;23:539-550 pubmed publisher |
Filbin M, Mehta A, Schneider A, Kays K, Guess J, Gentili M, et al. Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions. Cell Rep Med. 2021;2:100287 pubmed publisher |
Chan H, Leong Y, Voon S, Pan M, Leong C, Lim C, et al. Effects of Amyloid Precursor Protein Overexpression on NF-κB, Rho-GTPase and Pro-Apoptosis Bcl-2 Pathways in Neuronal Cells. Rep Biochem Mol Biol. 2021;9:417-425 pubmed publisher |
Wang C, Li H, Wu L, Jiao X, Jin Z, Zhu Y, et al. Coiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation. Front Oncol. 2021;11:668743 pubmed publisher |
Feng W, Simpson D, Cho J, Carvajal Garcia J, Smith C, Headley K, et al. Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks. Nucleic Acids Res. 2021;49:5095-5105 pubmed publisher |
van der Weyden L, Offord V, Turner G, Swiatkowska A, Speak A, Adams D. Membrane protein regulators of melanoma pulmonary colonisation identified using a CRISPRa screen and spontaneous metastasis assay in mice. G3 (Bethesda). 2021;: pubmed publisher |
Kerselidou D, Dohai B, Nelson D, Daakour S, De Cock N, Hassoun Z, et al. Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Sci Adv. 2021;7: pubmed publisher |
Jarroux J, Foretek D, Bertrand C, Gabriel M, Szachnowski U, Saci Z, et al. HOTAIR lncRNA promotes epithelial-mesenchymal transition by redistributing LSD1 at regulatory chromatin regions. EMBO Rep. 2021;22:e50193 pubmed publisher |
Piette B, Alerasool N, Lin Z, Lacoste J, Lam M, Qian W, et al. Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Mol Cell. 2021;81:2549-2565.e8 pubmed publisher |
Deliz Aguirre R, Cao F, Gerpott F, Auevechanichkul N, Chupanova M, Mun Y, et al. MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling. J Cell Biol. 2021;220: pubmed publisher |
Diehl V, Wegner M, Grumati P, Husnjak K, Schaubeck S, Gubas A, et al. Minimized combinatorial CRISPR screens identify genetic interactions in autophagy. Nucleic Acids Res. 2021;49:5684-5704 pubmed publisher |
Liu D, Song A, Qi X, van Vliet P, Xiao J, Xiong F, et al. Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel. Nat Commun. 2021;12:2551 pubmed publisher |
Chien M, Brinks D, Testa Silva G, Tian H, Phil Brooks F, Adam Y, et al. Photoactivated voltage imaging in tissue with an archaerhodopsin-derived reporter. Sci Adv. 2021;7: pubmed publisher |
Pettinato A, Yoo D, VanOudenhove J, Chen Y, Cohn R, Ladha F, et al. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Rep. 2021;35:109088 pubmed publisher |
Seydoux E, Wan Y, Feng J, Wall A, Aljedani S, Homad L, et al. Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies. Cell Rep. 2021;35:109084 pubmed publisher |
Behiels E, Elegheert J. High-Level Production of Recombinant Eukaryotic Proteins from Mammalian Cells Using Lentivirus. Methods Mol Biol. 2021;2305:83-104 pubmed publisher |
Scarborough A, Flaherty J, Hunter O, Liu K, Kumar A, Xing C, et al. SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. elife. 2021;10: pubmed publisher |
Zhang S, Yuan B, Lam J, Zhou J, Zhou X, Ramos Mandujano G, et al. Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis. Cell Discov. 2021;7:30 pubmed publisher |
Gonzalez Perez A, Stempel M, Wyler E, Urban C, Piras A, Hennig T, et al. The Zinc Finger Antiviral Protein ZAP Restricts Human Cytomegalovirus and Selectively Binds and Destabilizes Viral UL4/UL5 Transcripts. MBio. 2021;12: pubmed publisher |
Brielle S, Bavli D, Motzik A, Kan Tor Y, Sun X, Kozulin C, et al. Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Cai H, Liu X, Zhang F, Han Q, Liu Z, Xue W, et al. G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses. J Immunol. 2021;206:2453-2467 pubmed publisher |
Haga Y, Marrocco I, Noronha A, Uribe M, Nataraj N, Sekar A, et al. Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors. Cancer Res. 2021;81:3862-3875 pubmed publisher |
Martínez Greene J, Hernández Ortega K, Quiroz Baez R, Resendis Antonio O, Pichardo Casas I, Sinclair D, et al. Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. J Extracell Vesicles. 2021;10:e12087 pubmed publisher |
Laquatra C, Sanchez Martin C, Dinarello A, Cannino G, Minervini G, Moroni E, et al. HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. Cell Death Dis. 2021;12:434 pubmed publisher |
Woodley C, Romer A, Wang J, Guarnaccia A, Elion D, Maxwell J, et al. Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Oncogene. 2021;40:3593-3609 pubmed publisher |
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher |
Martin Sancho L, Lewinski M, Pache L, Stoneham C, Yin X, Becker M, et al. Functional landscape of SARS-CoV-2 cellular restriction. Mol Cell. 2021;81:2656-2668.e8 pubmed publisher |
Liscovitch Brauer N, Montalbano A, Deng J, Méndez Mancilla A, Wessels H, Moss N, et al. Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens. Nat Biotechnol. 2021;: pubmed publisher |
Klein F, Granier C, Zhao Y, Pan Q, Tong Z, Gschwend J, et al. Combination of Talazoparib and Palbociclib as a Potent Treatment Strategy in Bladder Cancer. J Pers Med. 2021;11: pubmed publisher |
Romaniuk Drapała A, Toton E, Konieczna N, Machnik M, Barczak W, Kowal D, et al. hTERT Downregulation Attenuates Resistance to DOX, Impairs FAK-Mediated Adhesion, and Leads to Autophagy Induction in Breast Cancer Cells. Cells. 2021;10: pubmed publisher |
Motais B, Charvátová S, Walek Z, Hrdinka M, Smolarczyk R, Cichon T, et al. Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment. Cells. 2021;10: pubmed publisher |
Shibata S, Shibata N, Ohtsuka S, Yoshitomi Y, Kiyokawa E, Yonekura H, et al. Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Cells. 2021;10: pubmed publisher |
Huang X, Tan S, Li Y, Cao S, Li X, Pan H, et al. Caspase inhibition prolongs inflammation by promoting a signaling complex with activated RIPK1. J Cell Biol. 2021;220: pubmed publisher |
Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, et al. Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep. 2021;35:109024 pubmed publisher |
Yokoyama D, Hisamori S, Deguchi Y, Nishigori T, Okabe H, Kanaya S, et al. PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma. Sci Rep. 2021;11:9013 pubmed publisher |
Chen T, Zeineldin M, Johnson B, Dong Y, Narkar A, Li T, et al. Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury. Neoplasia. 2021;23:488-501 pubmed publisher |
Müller T, Zila V, Peters K, Schifferdecker S, Stanic M, Lucic B, et al. HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells. elife. 2021;10: pubmed publisher |
Molnar T, Pallagi P, Tél B, Kiraly R, Csoma E, Jenei V, et al. Caspase-9 acts as a regulator of necroptotic cell death. FEBS J. 2021;: pubmed publisher |
Alda Catalinas C, Eckersley Maslin M, Reik W. Pooled CRISPR-activation screening coupled with single-cell RNA-seq in mouse embryonic stem cells. STAR Protoc. 2021;2:100426 pubmed publisher |
Luo Q, Wu X, Zhao P, Nan Y, Chang W, Zhu X, et al. OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Adv Sci (Weinh). 2021;8:2002874 pubmed publisher |
Bevacqua R, Dai X, Lam J, Gu X, Friedlander M, Tellez K, et al. CRISPR-based genome editing in primary human pancreatic islet cells. Nat Commun. 2021;12:2397 pubmed publisher |
Barger C, Chee L, Albahrani M, Munoz Trujillo C, Boghean L, Branick C, et al. Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer. elife. 2021;10: pubmed publisher |
Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, et al. BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Sci Rep. 2021;11:8735 pubmed publisher |
Wu S, Jiang Y, Hong Y, Chu X, Zhang Z, Tao Y, et al. BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes. Cancer Cell Int. 2021;21:230 pubmed publisher |
Bowman S, Le L, Zhu Y, Harper D, Sitaram A, Theos A, et al. A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers. J Cell Biol. 2021;220: pubmed publisher |
Chen C, Li S, Xue J, Qi M, Liu X, Huang Y, et al. PD-L1 tumor-intrinsic signaling and its therapeutic implication in triple-negative breast cancer. JCI Insight. 2021;6: pubmed publisher |
Le Voyer T, Neehus A, Yang R, Ogishi M, Rosain J, Alroqi F, et al. Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Hayman T, Baro M, MacNeil T, Phoomak C, Aung T, Cui W, et al. STING enhances cell death through regulation of reactive oxygen species and DNA damage. Nat Commun. 2021;12:2327 pubmed publisher |
Xia L, Zheng Z, Liu J, Chen Y, Ding J, Hu G, et al. Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition. Cancer Immunol Res. 2021;9:707-722 pubmed publisher |
Lee D, Kang S, Choi D, Ko M, Choi E, Ahn H, et al. Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells. Cancer Lett. 2021;510:37-47 pubmed publisher |
Wang X, Zhang H, Sapio R, Yang J, Wong J, Zhang X, et al. SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer. Nat Commun. 2021;12:2259 pubmed publisher |
Saydam O, Saydam N. Deficiency of Ku Induces Host Cell Exploitation in Human Cancer Cells. Front Cell Dev Biol. 2021;9:651818 pubmed publisher |
Trinkaus V, Riera Tur I, Martinez Sanchez A, Bäuerlein F, Guo Q, Arzberger T, et al. In situ architecture of neuronal α-Synuclein inclusions. Nat Commun. 2021;12:2110 pubmed publisher |
Durens M, Soliman M, MILLONIG J, Dicicco Bloom E. Engrailed-2 is a cell autonomous regulator of neurogenesis in cultured hippocampal neural stem cells. Dev Neurobiol. 2021;81:724-735 pubmed publisher |
Corbin J, Georgescu C, Wren J, Xu C, Asch A, Ruiz Echevarría M. Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. Mol Ther Nucleic Acids. 2021;24:337-351 pubmed publisher |
Millul J, Bassi G, Mock J, Elsayed A, Pellegrino C, Zana A, et al. An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Aldea D, Atsuta Y, Kokalari B, Schaffner S, Prasasya R, Aharoni A, et al. Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Pradhan A, Lu D, Parisi L, Shen S, Berhane I, Galster S, et al. Protein acylation by saturated very long chain fatty acids and endocytosis are involved in necroptosis. Cell Chem Biol. 2021;: pubmed publisher |
Weiss R, Spahn P, Chiang A, Liu Q, Li J, Hamill K, et al. Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate. Nat Chem Biol. 2021;17:684-692 pubmed publisher |
Laurent E, Sieber A, Salzer B, Wachernig A, Seigner J, Lehner M, et al. Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients. ACS Synth Biol. 2021;10:1184-1198 pubmed publisher |
Monserrat J, Morales Torres C, Richardson L, Wilson T, Patel H, Domart M, et al. Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability. Nat Cell Biol. 2021;23:401-412 pubmed publisher |
Liu R, Tan J, Shen X, Jiang K, Wang C, Zhu G, et al. Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Clark S, Clark L, Pan J, Coscia A, McKay L, Shankar S, et al. SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Cell. 2021;184:2605-2617.e18 pubmed publisher |
Thamodaran V, Rani S, Velayudhan S. Gene Editing in Human Induced Pluripotent Stem Cells Using Doxycycline-Inducible CRISPR-Cas9 System. Methods Mol Biol. 2021;: pubmed publisher |
Jiang H, Song S, Li J, Yin Q, Hu S, Nie Y. Establishment and characterization of an immortalized epicardial cell line. J Cell Mol Med. 2021;: pubmed publisher |
Nakamura T, Ogawa M, Kojima K, Takayanagi S, Ishihara S, Hattori K, et al. The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress-induced ferroptosis. EMBO Rep. 2021;22:e51532 pubmed publisher |
Wang H, Luo Q, Kang J, Wei Q, Yang Y, Yang D, et al. YTHDF1 Aggravates the Progression of Cervical Cancer Through m6A-Mediated Up-Regulation of RANBP2. Front Oncol. 2021;11:650383 pubmed publisher |
Gómez Ferrer M, Villanueva Badenas E, Sánchez Sánchez R, Sánchez López C, Baquero M, Sepulveda P, et al. HIF-1α and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles. Int J Mol Sci. 2021;22: pubmed publisher |
Bagchi A, Nath A, Thamodaran V, Ijee S, Palani D, Rajendiran V, et al. Direct Generation of Immortalized Erythroid Progenitor Cell Lines from Peripheral Blood Mononuclear Cells. Cells. 2021;10: pubmed publisher |
Yamazaki M, Sugimoto K, Mabuchi Y, Yamashita R, Ichikawa Tomikawa N, Kaneko T, et al. Soluble JAM-C Ectodomain Serves as the Niche for Adipose-Derived Stromal/Stem Cells. Biomedicines. 2021;9: pubmed publisher |
Arias Arias J, Mora Rodriguez R. Generation and Implementation of Reporter BHK-21 Cells for Live Imaging of Flavivirus Infection. Bio Protoc. 2021;11:e3942 pubmed publisher |
Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, et al. m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. Nat Cell Biol. 2021;23:355-365 pubmed publisher |
Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed publisher |
Ito R, Oneyama C, Aoki K. Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction. PLoS ONE. 2021;16:e0249388 pubmed publisher |
Li D, Tang L, Liu B, Xu S, Jin M, Bo W. RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma. Aging (Albany NY). 2021;13:10450-10467 pubmed publisher |
Cho E, Lou H, Kuruvilla L, Calderwood D, Turk B. PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cell Rep. 2021;34:108928 pubmed publisher |
Sanz Moreno A, Palomeras S, Pedersen K, Morancho B, Pascual T, Galvan P, et al. RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Breast Cancer Res. 2021;23:42 pubmed publisher |
Gingrich J, Pu Y, Veiga Lopez A. A modified parachute assay for assessment of gap junction intercellular communication in placental trophoblast cells. Toxicol Mech Methods. 2021;31:393-399 pubmed publisher |
Schwab M, Lohr S, Schneider J, Kaiser M, Krunic D, Helbig D, et al. Podoplanin is required for tumor cell invasion in cutaneous squamous cell carcinoma. Exp Dermatol. 2021;: pubmed publisher |
Ditano J, Donahue K, Tafe L, McCleery C, Eastman A. Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Sci Rep. 2021;11:7077 pubmed publisher |
Li J, Urabe G, Huang Y, Zhang M, Wang B, Marcho L, et al. A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition. JACC Basic Transl Sci. 2021;6:257-283 pubmed publisher |
Wei Y, Jiang Z, Lu J. USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization. Oncol Lett. 2021;21:394 pubmed publisher |
de Mattos Barbosa M, Liu H, Huynh D, Shelley G, Keller E, Emmer B, et al. IgV somatic mutation of human anti-SARS-CoV-2 monoclonal antibodies governs neutralization and breadth of reactivity. JCI Insight. 2021;6: pubmed publisher |
Takahashi M, Lio C, Campeau A, Steger M, Ay F, Mann M, et al. The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway. Nat Immunol. 2021;22:485-496 pubmed publisher |
Gilad Y, Eliaz Y, Yu Y, Dean A, Han S, Qin L, et al. A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021;4:399 pubmed publisher |
Driskill J, Zheng Y, Wu B, Wang L, Cai J, Rakheja D, et al. WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma. Genes Dev. 2021;35:495-511 pubmed publisher |
Wang P, Zhao L, Gong S, Xiong S, Wang J, Zou D, et al. HIF1α/HIF2α-Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR-PI3K/AKT signalling pathway with positive feedback under hypoxia. Cell Death Dis. 2021;12:312 pubmed publisher |
Burckhardt C, Minna J, Danuser G. SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt. Dev Cell. 2021;56:1164-1181.e12 pubmed publisher |
Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, et al. Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry. PLoS Pathog. 2021;17:e1009392 pubmed publisher |
Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, et al. Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Nat Commun. 2021;12:1826 pubmed publisher |
Warwick T, Schulz M, Günther S, Gilsbach R, Neme A, Carlberg C, et al. A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Sci Rep. 2021;11:6518 pubmed publisher |
Kim S, Wong Y, Gao F, Krainc D. Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson's disease. Nat Commun. 2021;12:1807 pubmed publisher |
Zhang Q, Song X, Ma P, Lv L, Zhang Y, Deng J, et al. Human Cytomegalovirus miR-US33as-5p Targets IFNAR1 to Achieve Immune Evasion During Both Lytic and Latent Infection. Front Immunol. 2021;12:628364 pubmed publisher |
Ahmed M, Soares F, Xia J, Yang Y, Li J, Guo H, et al. CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer. Nat Commun. 2021;12:1781 pubmed publisher |
Mshaik R, Simonet J, Georgievski A, Jamal L, Bechoua S, Ballerini P, et al. HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias. Blood Cancer J. 2021;11:61 pubmed publisher |
Liu Y, Zou L, Wang P, Zhou J, Yuan C, Wang J. Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation. Exp Ther Med. 2021;21:363 pubmed publisher |
Maeda R, Kami D, Shikuma A, Suzuki Y, Taya T, Matoba S, et al. RNA decay in processing bodies is indispensable for adipogenesis. Cell Death Dis. 2021;12:285 pubmed publisher |
Brandao R, Kwa M, Yarden Y, Brakebusch C. ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation. FEBS Open Bio. 2021;11:1579-1592 pubmed publisher |
Kojima M, Sugimoto K, Kobayashi M, Ichikawa Tomikawa N, Kashiwagi K, Watanabe T, et al. Aberrant Claudin-6-Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α. Mol Cancer Res. 2021;19:1208-1220 pubmed publisher |
Yu J, Li Z, He X, Gebre M, Bondzie E, Wan H, et al. Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays. J Virol. 2021;: pubmed publisher |
Liu Z, Guo C, Das S, Yu X, Pradhan A, Li X, et al. Engineering T Cells to Express Tumoricidal MDA-7/IL24 Enhances Cancer Immunotherapy. Cancer Res. 2021;81:2429-2441 pubmed publisher |
Wang W, Zhu Y, Sun Z, Jin C, Wang X. Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling. Arthritis Res Ther. 2021;23:84 pubmed publisher |
Seymour B, Singh S, Certo H, Sommer K, Sather B, Khim S, et al. Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector. Mol Ther Methods Clin Dev. 2021;20:635-651 pubmed publisher |
Zhao H, Zhang Y, Xu X, Sun Q, Yang C, Wang H, et al. Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury. Front Cell Dev Biol. 2021;9:608367 pubmed publisher |
Yan C, Chen J, Ding Y, Zhou Z, Li B, Deng C, et al. The Crucial Role of PPARγ-Egr-1-Pro-Inflammatory Mediators Axis in IgG Immune Complex-Induced Acute Lung Injury. Front Immunol. 2021;12:634889 pubmed publisher |
Dong R, Xue Z, Fan G, Zhang N, Wang C, Li G, et al. Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock. Front Immunol. 2021;12:620238 pubmed publisher |
Wang C, Sample K, Gajendran B, Kapranov P, Liu W, Hu A, et al. FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome. Front Immunol. 2021;12:607836 pubmed publisher |
Zhang C, Gao Y, Jadhav U, Hung H, Holton K, Grodzinsky A, et al. Creb5 establishes the competence for Prg4 expression in articular cartilage. Commun Biol. 2021;4:332 pubmed publisher |
Yan L, Song Y, Xia K, He P, Zhang F, Chen S, et al. Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus. Carbohydr Polym. 2021;260:117797 pubmed publisher |
Ju X, Zhu Y, Wang Y, Li J, Zhang J, Gong M, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLoS Pathog. 2021;17:e1009439 pubmed publisher |
Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, et al. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Res. 2021;49:4203-4219 pubmed publisher |
Yang Y, Wu W, Liu T, Dong L, Lei H. A robust method for protein depletion based on gene editing. Methods. 2021;: pubmed publisher |
Huang C, Li G, Wu J, Liang J, Wang X. Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Genome Biol. 2021;22:80 pubmed publisher |
Roy V, Lamontagne R, Talagas M, Touzel Deschênes L, Khuong H, Saikali S, et al. Biofabrication of a three dimensional human-based personalized neurofibroma model. Biotechnol J. 2021;16:e2000250 pubmed publisher |
Luo J, Zou H, Deng L, Sun X, Yuan P, Li P. Lin28 Inhibits the Differentiation from Mouse Embryonic Stem Cells to Glial Lineage Cells through Upregulation of Yap1. Stem Cells Int. 2021;2021:6674283 pubmed publisher |
Ozawa T, Kaneko S, Szulzewsky F, Qiao Z, Takadera M, Narita Y, et al. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Acta Neuropathol Commun. 2021;9:36 pubmed publisher |
Zhang W, Wang Q, Yang F, Zhu Z, Duan Y, Yang Y, et al. JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination. PLoS Pathog. 2021;17:e1009366 pubmed publisher |
Li J, Ullah M, Jin H, Liang Y, Lin L, Wang J, et al. ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy-Dependent Pathway. Front Immunol. 2021;12:604974 pubmed publisher |
Bailey E, Choudhury A, Vuppula H, Ortiz D, Schaeck J, Manning A, et al. Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes. Front Immunol. 2020;11:617767 pubmed publisher |
Yoodee S, Peerapen P, Plumworasawat S, Thongboonkerd V. ARID1A knockdown in human endothelial cells directly induces angiogenesis by regulating angiopoietin-2 secretion and endothelial cell activity. Int J Biol Macromol. 2021;180:1-13 pubmed publisher |
Lee M, Nam H, Kang H, Lee W, Lee G, Sung G, et al. Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction. Cell Death Dis. 2021;12:250 pubmed publisher |
Mukenhirn M, Muraca F, Bucher D, Asberger E, Cappio Barazzone E, Cavalcanti Adam E, et al. Role of Clathrin Light Chains in Regulating Invadopodia Formation. Cells. 2021;10: pubmed publisher |
Klement J, Poschel D, Lu C, Merting A, Yang D, Redd P, et al. Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression. Cancers (Basel). 2021;13: pubmed publisher |
Lapaillerie D, Charlier C, Fernandes H, Sousa S, Lesbats P, Weigel P, et al. In Silico, In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell Fusion. Viruses. 2021;13: pubmed publisher |
Tso F, Lidenge S, Poppe L, Peña P, Privatt S, Bennett S, et al. Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma. PLoS ONE. 2021;16:e0247640 pubmed publisher |
Zhao G, Zhu X, Zhang H, Chen Y, Schieck E, Hu C, et al. Novel Secreted Protein of Mycoplasma bovis MbovP280 Induces Macrophage Apoptosis Through CRYAB. Front Immunol. 2021;12:619362 pubmed publisher |
Yamamoto S, Yabuki R, Kitagawa D. Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis. Biol Open. 2021;10: pubmed publisher |
McFadden M, McIntyre A, Mourelatos H, Abell N, Gokhale N, Ipas H, et al. Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine. Cell Rep. 2021;34:108798 pubmed publisher |
Kim S, Kim Y, Hyun Y, Choi H, Kim S, Kim T. Exosomes from human cord blood plasma accelerate cutaneous wound healing by promoting fibroblast function, angiogenesis, and M2 macrophage differentiation. Biomater Sci. 2021;9:3028-3039 pubmed publisher |
Großkopf A, Schlagowski S, Fricke T, Ensser A, Desrosiers R, Hahn A. Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). PLoS Pathog. 2021;17:e1008979 pubmed publisher |
Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu J, et al. Transcription factor competition at the γ-globin promoters controls hemoglobin switching. Nat Genet. 2021;53:511-520 pubmed publisher |
Yan H, Jiao H, Liu Q, Zhang Z, Xiong Q, Wang B, et al. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nat Ecol Evol. 2021;5:600-608 pubmed publisher |
Torrence M, MacArthur M, Hosios A, Valvezan A, Asara J, Mitchell J, et al. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. elife. 2021;10: pubmed publisher |
Yamanaka D, Shoda M, Matsubara T, Ishibashi K, Motoi A, Motoi R, et al. Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Agaricomycetes), on β-Glucan-Specific Antibody Production in Healthy Human Volunteers. Int J Med Mushrooms. 2021;23:13-28 pubmed publisher |
Kennedy A, Myers K, Bowman J, Gibson C, Camarda N, Furutani E, et al. Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Nat Commun. 2021;12:1334 pubmed publisher |
Thompson N, Ranzani M, van der Weyden L, Iyer V, Offord V, Droop A, et al. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Nat Commun. 2021;12:1302 pubmed publisher |
Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, et al. In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions. Cell. 2021;184:1245-1261.e21 pubmed publisher |
Mattsson J, Ekdahl L, Junghus F, Ajore R, Erlandsson E, Niroula A, et al. Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing. Nat Commun. 2021;12:1277 pubmed publisher |
Arenas E, Martínez Sabadell A, Rius Ruiz I, Román Alonso M, Escorihuela M, Luque A, et al. Acquired cancer cell resistance to T cell bispecific antibodies and CAR T targeting HER2 through JAK2 down-modulation. Nat Commun. 2021;12:1237 pubmed publisher |
Jiang X, Prabhakar A, van der Voorn S, Ghatpande P, Celona B, Venkataramanan S, et al. Control of ribosomal protein synthesis by the Microprocessor complex. Sci Signal. 2021;14: pubmed publisher |
Chidawanyika T, Chakrabarti R, Beauchemin K, Higgs H, Supattapone S. SEC24A facilitates colocalization and Ca2 + flux between the endoplasmic reticulum and mitochondria. J Cell Sci. 2021;134: pubmed publisher |
Chan W, Gottschalk R, Yao Y, Pomerantz J, Germain R. Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools. Immunohorizons. 2021;5:117-132 pubmed publisher |
Head S, Hernandez Alias X, Yang J, Ciampi L, Beltrán Sastre V, Torres Méndez A, et al. Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers. PLoS Biol. 2021;19:e3001138 pubmed publisher |
Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, et al. Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Acta Neuropathol Commun. 2021;9:29 pubmed publisher |
Bloemberg D, Sosa Miranda C, Nguyen T, Weeratna R, McComb S. Self-Cutting and Integrating CRISPR Plasmids Enable Targeted Genomic Integration of Genetic Payloads for Rapid Cell Engineering. CRISPR J. 2021;4:104-119 pubmed publisher |
Guduric Fuchs J, Pedrini E, Lechner J, Chambers S, O Neill C, Mendes Lopes de Melo J, et al. miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia. Mol Ther Nucleic Acids. 2021;23:968-981 pubmed publisher |
Navarro Guerrero E, Tay C, Whalley J, Cowley S, Davies B, Knight J, et al. Genome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages. Sci Rep. 2021;11:4245 pubmed publisher |
Hörnich B, Großkopf A, Schlagowski S, Tenbusch M, Kleine Weber H, Neipel F, et al. SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation. J Virol. 2021;95: pubmed publisher |
Fu L, Li S, Xiao W, Yu K, Li S, Yuan S, et al. DGKA Mediates Resistance to PD-1 Blockade. Cancer Immunol Res. 2021;9:371-385 pubmed publisher |
Vigont V, Grekhnev D, Lebedeva O, Gusev K, Volovikov E, Skopin A, et al. STIM2 Mediates Excessive Store-Operated Calcium Entry in Patient-Specific iPSC-Derived Neurons Modeling a Juvenile Form of Huntington's Disease. Front Cell Dev Biol. 2021;9:625231 pubmed publisher |
Cararo Lopes E, Dias M, Da Silva M, Zeidler J, Vessoni A, Reis M, et al. Autophagy buffers Ras-induced genotoxic stress enabling malignant transformation in keratinocytes primed by human papillomavirus. Cell Death Dis. 2021;12:194 pubmed publisher |
Kim C, Sung S, Kim J, Lee H, Jung Y, Shin S, et al. Telomeres reforged with non-telomeric sequences in mouse embryonic stem cells. Nat Commun. 2021;12:1097 pubmed publisher |
Silveira M, Tav C, Bérubé Simard F, Cuppens T, Leclercq M, Fournier E, et al. Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response. Life Sci Alliance. 2021;4: pubmed publisher |
Adams S, Csere J, D Angelo G, Carter E, Romao M, Arnandis T, et al. Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Curr Biol. 2021;31:1403-1416.e7 pubmed publisher |
Ferrara P, Rong X, Maschek J, Verkerke A, Siripoksup P, Song H, et al. Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. J Clin Invest. 2021;131: pubmed publisher |
Alexander J, Vendramini Costa D, Francescone R, Luong T, Franco Barraza J, Shah N, et al. Palladin isoforms 3 and 4 regulate cancer-associated fibroblast pro-tumor functions in pancreatic ductal adenocarcinoma. Sci Rep. 2021;11:3802 pubmed publisher |
Rybakova Y, Gonzalez J, Bogorad R, Chauhan V, Dong Y, Whittaker C, et al. Identification of a long non-coding RNA regulator of liver carcinoma cell survival. Cell Death Dis. 2021;12:178 pubmed publisher |
Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, et al. FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. J Cell Mol Med. 2021;: pubmed publisher |
Beltrán Pavez C, Riquelme Barrios S, Oyarzún Arrau A, Gaete Argel A, González Stegmaier R, Cereceda Solis K, et al. Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile. Sci Adv. 2021;7: pubmed publisher |
Rother M, Naumann M. Signal peptidase complex subunit 1 is an essential Zika virus host factor in placental trophoblasts. Virus Res. 2021;:198338 pubmed publisher |
Jia R, Bonifacino J. The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity. J Biol Chem. 2021;296:100405 pubmed publisher |
Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, et al. A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Nat Commun. 2021;12:961 pubmed publisher |
Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Mol Cell. 2021;: pubmed publisher |
Nims R, Pferdehirt L, Ho N, Savadipour A, Lorentz J, Sohi S, et al. A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. Sci Adv. 2021;7: pubmed publisher |
Srivastava S, Sahu U, Zhou Y, Hogan A, Sathyan K, Bodner J, et al. NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Sci Adv. 2021;7: pubmed publisher |
Dos Santos Passos C, Choi Y, Snow C, Yao T, Cohen R. Design of genetically encoded sensors to detect nucleosome ubiquitination in live cells. J Cell Biol. 2021;220: pubmed publisher |
Daniloski Z, Jordan T, Ilmain J, Guo X, Bhabha G, tenOever B, et al. The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types. elife. 2021;10: pubmed publisher |
Baquero J, Benitez Buelga C, Rajagopal V, Zhenjun Z, Torres Ruiz R, Muller S, et al. Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Sci Rep. 2021;11:3490 pubmed publisher |
Ducoli L, Agrawal S, Sibler E, Kouno T, Tacconi C, Hon C, et al. LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. Nat Commun. 2021;12:925 pubmed publisher |
Vollmers A, Covarrubias S, Kuang D, Shulkin A, Iwuagwu J, Katzman S, et al. A conserved long noncoding RNA, GAPLINC, modulates the immune response during endotoxic shock. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Ma S, McGuire M, Mangala L, Lee S, Stur E, Hu W, et al. Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Cell Rep. 2021;34:108726 pubmed publisher |
Wang Y, Xie Y, Dong Z, Jiang X, Gong P, Lu J, et al. [Levels of sgRNA as a Major Factor Affecting CRISPRi Knockdown Efficiency in K562 Cells]. Mol Biol (Mosk). 2021;55:86-95 pubmed publisher |
Xiang X, Langlois S, St Pierre M, Blinder A, Charron P, Graber T, et al. Identification of pannexin 1-regulated genes, interactome, and pathways in rhabdomyosarcoma and its tumor inhibitory interaction with AHNAK. Oncogene. 2021;: pubmed publisher |
Li J, Mahata B, Escobar M, Goell J, Wang K, Khemka P, et al. Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase. Nat Commun. 2021;12:896 pubmed publisher |
Na J, Newman J, Then C, Syed J, Vendrell I, Torrecilla I, et al. SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. Cell Death Dis. 2021;12:165 pubmed publisher |
Didychuk A, Gates S, Gardner M, Strong L, Martin A, Glaunsinger B. A pentameric protein ring with novel architecture is required for herpesviral packaging. elife. 2021;10: pubmed publisher |
Xu Y, Nasri M, Dannenmann B, Mir P, Zahabi A, Welte K, et al. NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells. Stem Cell Res Ther. 2021;12:112 pubmed publisher |
Rother M, Dimmler C, Weege F, Mollenkopf H, Meyer T, Naumann M. Discovery of Zika virus host dependency factors in trophoblasts using CRISPR/Cas9 screening. J Virol Methods. 2021;290:114085 pubmed publisher |
Marcellus K, Crawford Parks T, Almasi S, Jasmin B. Distinct roles for the RNA-binding protein Staufen1 in prostate cancer. BMC Cancer. 2021;21:120 pubmed publisher |
Yan L, Tsujita K, Fujita Y, Itoh T. PTEN is required for the migration and invasion of Ras-transformed MDCK cells. FEBS Lett. 2021;: pubmed publisher |
Hundley F, Sanvisens Delgado N, Marin H, Carr K, Tian R, Toczyski D. A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis. Mol Cell. 2021;: pubmed publisher |
Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, et al. PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. Mol Cell. 2021;81:1276-1291.e9 pubmed publisher |
Xu L, Zu T, Li T, Li M, Mi J, Bai F, et al. ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. PLoS Genet. 2021;17:e1009283 pubmed publisher |
Patel P, Abraham K, Guturi K, Halaby M, Khan Z, Palomero L, et al. RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. J Clin Invest. 2021;131: pubmed publisher |
Fazio M, van Rooijen E, Dang M, van de Hoek G, Ablain J, Mito J, et al. SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. elife. 2021;10: pubmed publisher |
Condor Capcha J, Lambert G, Dykxhoorn D, Salerno A, Hare J, Whitt M, et al. Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol. Front Cardiovasc Med. 2020;7:618651 pubmed publisher |
Xu A, Huang M, Zhu D, Gingold J, Bazer D, Chang B, et al. LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes. Front Genet. 2020;11:611823 pubmed publisher |
Huang Y, Tejero R, Lee V, Brusco C, Hannah T, Bertucci T, et al. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics. Commun Biol. 2021;4:145 pubmed publisher |
Patel A, Yoo S, Kong R, Sato T, Sinha A, Karam S, et al. Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer. Sci Adv. 2021;7: pubmed publisher |
McLellan L, McAllaster M, Kim A, Tothova L, Olson P, Pinkner J, et al. A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis. PLoS Pathog. 2021;17:e1009314 pubmed publisher |
Traxel S, Lehmann J, Richard S, Sidorov S, Niggli F, Berger C, et al. Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis. Cancer Immunol Immunother. 2021;: pubmed publisher |
Han T, Sha H, Ji J, Li Y, Wu D, Lin H, et al. Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage. Sci Rep. 2021;11:2283 pubmed publisher |
Jain S, Shukla S, Yang C, Zhang M, Fatma Z, Lingamaneni M, et al. TALEN outperforms Cas9 in editing heterochromatin target sites. Nat Commun. 2021;12:606 pubmed publisher |
Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, et al. IDH1 mutations induce organelle defects via dysregulated phospholipids. Nat Commun. 2021;12:614 pubmed publisher |
Inukai R, Mori K, Kuwata K, Suzuki C, Maki M, Takahara T, et al. The Novel ALG-2 Target Protein CDIP1 Promotes Cell Death by Interacting with ESCRT-I and VAPA/B. Int J Mol Sci. 2021;22: pubmed publisher |
Addison J, Voronkova M, Fugett J, Lin C, Linville N, Trinh B, et al. Functional hierarchy and cooperation of EMT master transcription factors in breast cancer metastasis. Mol Cancer Res. 2021;: pubmed publisher |
Prentzell M, Rehbein U, Cadena Sandoval M, De Meulemeester A, Baumeister R, Brohée L, et al. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021;184:655-674.e27 pubmed publisher |
Kayamori K, Nagai Y, Zhong C, Kaito S, Shinoda D, Koide S, et al. DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes. Blood Adv. 2021;5:438-450 pubmed publisher |
Malnar M, Rogelj B. SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72. J Cell Sci. 2021;: pubmed publisher |
Zhu M, Huang Y, Bender M, Girard L, Kollipara R, Eglenen Polat B, et al. Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. Cancer Res. 2021;: pubmed publisher |
Chan S, Smith E, Gao Y, Kwan J, Blum B, Tilston Lünel A, et al. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020;8:608044 pubmed publisher |
Liu S, Wu M, Lancelot M, Deng J, Gao Y, Roback J, et al. BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells. Mol Ther. 2021;: pubmed publisher |
Tewari R, Shayahati B, Fan Y, Akimzhanov A. T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells. J Biol Chem. 2021;:100311 pubmed publisher |
Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, Maciejowski J. ER-directed TREX1 limits cGAS activation at micronuclei. Mol Cell. 2021;: pubmed publisher |
Maia A, Gu Z, Koch A, Berdiel Acer M, Will R, Schlesner M, et al. IFNβ1 secreted by breast cancer cells undergoing chemotherapy reprograms stromal fibroblasts to support tumour growth after treatment. Mol Oncol. 2021;: pubmed publisher |
Zhu N, Zhang C, Prakash A, Hou Z, Liu W, She W, et al. Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR. EMBO Mol Med. 2021;:e12651 pubmed publisher |
Li S, Kuang M, Chen L, Li Y, Liu S, Du H, et al. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Cell Rep. 2021;34:108631 pubmed publisher |
Dong C, An L, Yu C, Huen M. A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Res. 2021;: pubmed publisher |
Xiao H, Wyler E, Milek M, Grewe B, Kirchner P, Ekici A, et al. CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs. MBio. 2021;12: pubmed publisher |
Perry E, Bennett C, Luo C, Balsa E, Jedrychowski M, O Malley K, et al. Tetracyclines promote survival and fitness in mitochondrial disease models. Nat Metab. 2021;3:33-42 pubmed publisher |
Kumar J, Kumar R, Kumar Singh A, Tsakem E, Kathania M, Riese M, et al. Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function. J Immunother Cancer. 2021;9: pubmed publisher |
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy. 2021;:1-20 pubmed publisher |
Wang Z, Pan Z, Adhikari S, Harada B, Shen L, Yuan W, et al. m6 A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region. EMBO J. 2021;:e106309 pubmed publisher |
Bullerwell C, Robichaud P, Deprez P, Joy A, Wajnberg G, D Souza D, et al. EBF1 drives hallmark B cell gene expression by enabling the interaction of PAX5 with the MLL H3K4 methyltransferase complex. Sci Rep. 2021;11:1537 pubmed publisher |
Lo Y, Kolahi K, Du Y, Chang C, Krokhotin A, Nair A, et al. A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation. Cancer Discov. 2021;11:1562-1581 pubmed publisher |
Hemming M, Coy S, Lin J, Andersen J, Przybyl J, Mazzola E, et al. HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Clin Cancer Res. 2021;: pubmed publisher |
Tajan M, Hennequart M, Cheung E, Zani F, Hock A, Legrave N, et al. Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nat Commun. 2021;12:366 pubmed publisher |
Bevacqua R, Lam J, Peiris H, Whitener R, Kim S, Gu X, et al. SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells. Genes Dev. 2021;35:234-249 pubmed publisher |
Roliński M, Montaldo N, Aksu M, Fordyce Martin S, Brambilla A, Kunath N, et al. Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Nucleic Acids Res. 2021;: pubmed publisher |
Heintze T, Klein K, Hofmann U, Zanger U. Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells. Sci Rep. 2021;11:1000 pubmed publisher |
Mittler E, Alkutkar T, Jangra R, Chandran K. Direct Intracellular Visualization of Ebola Virus-Receptor Interaction by In Situ Proximity Ligation. MBio. 2021;12: pubmed publisher |
Yadav K, Boley P, Fritts Z, Kenney S. Ectopic Expression of Genotype 1 Hepatitis E Virus ORF4 Increases Genotype 3 HEV Viral Replication in Cell Culture. Viruses. 2021;13: pubmed publisher |
Ramalingam N, Dettmer U. Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. J Biol Chem. 2021;:100271 pubmed publisher |
Wu B, Zhang S, Guo Z, Bi Y, Zhou M, Li P, et al. The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation. Immunity. 2021;54:308-323.e6 pubmed publisher |
Yin X, Wang Y, Wang F, Feng W, Bai S, Zhao W, et al. PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Oncogene. 2021;: pubmed publisher |
Hou G, Harley I, Lu X, Zhou T, Xu N, Yao C, et al. SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Nat Commun. 2021;12:135 pubmed publisher |
Pomella S, Sreenivas P, Gryder B, Wang L, Milewski D, Cassandri M, et al. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021;12:192 pubmed publisher |
Habekost M, Qvist P, Denham M, Holm I, Jørgensen A. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Mol Neurobiol. 2021;: pubmed publisher |
Huang Z, Zhang Q, Wang Y, Chen R, Wang Y, Huang Z, et al. Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy. Am J Cancer Res. 2020;10:4287-4307 pubmed |
Kajiwara K, Beharier O, Chng C, Goff J, Ouyang Y, St Croix C, et al. Ferroptosis induces membrane blebbing in placental trophoblasts. J Cell Sci. 2021;: pubmed publisher |
Zhou J, Li J, Li H, Zhang Y, Dong W, Jin Y, et al. The serine-48 residue of nucleolar phosphoprotein nucleophosmin-1 plays critical role in subcellular localization and interaction with porcine circovirus type 3 capsid protein. Vet Res. 2021;52:4 pubmed publisher |
Tsu B, Beierschmitt C, Ryan A, Agarwal R, Mitchell P, Daugherty M. Diverse viral proteases activate the NLRP1 inflammasome. elife. 2021;10: pubmed publisher |
Li X, Zou T, Wang S, Wu H, Wu M, Liu Z, et al. Mechanism and restoration strategy of lysosomal abnormalities induced by urinary protein overload in proximal tubule epithelial cells. Dev Dyn. 2021;: pubmed publisher |
Chiavarina B, Costanza B, Ronca R, Blomme A, Rezzola S, Chiodelli P, et al. Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis. Theranostics. 2021;11:1626-1640 pubmed publisher |
Shirasaki R, Matthews G, Gandolfi S, de Matos Simoes R, Buckley D, Raja Vora J, et al. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Rep. 2021;34:108532 pubmed publisher |
Muendlein H, Connolly W, Magri Z, Smirnova I, Ilyukha V, Gautam A, et al. ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1. Nat Commun. 2021;12:86 pubmed publisher |
Kajal K, Bose S, Panda A, Chakraborty D, Chakraborty S, Pati S, et al. Transcriptional regulation of VEGFA expression in T-regulatory cells from breast cancer patients. Cancer Immunol Immunother. 2021;: pubmed publisher |
Chen G, Liao Z, Liu J, Li F, Huang D, Zhou Y. LncRNA FTX Promotes Colorectal Cancer Cells Migration and Invasion by miRNA-590-5p/RBPJ Axis. Biochem Genet. 2021;59:560-573 pubmed publisher |
Ollivier M, Beudez J, Linck N, Grutter T, Compan V, Rassendren F. P2X-GCaMPs as Versatile Tools for Imaging Extracellular ATP Signaling. Eneuro. 2021;8: pubmed publisher |
Brown L, Dong W, Kantor B. An Improved Protocol for the Production of Lentiviral Vectors. STAR Protoc. 2020;1:100152 pubmed publisher |
Damnernsawad A, Bottomly D, Kurtz S, Eide C, McWeeney S, Tyner J, et al. Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia. Haematologica. 2020;Online ahead of print: pubmed publisher |
Balce D, Wang Y, McAllaster M, Dunlap B, Orvedahl A, Hykes B, et al. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Dai M, Boudreault J, Wang N, Poulet S, Daliah G, Yan G, et al. Differential regulation of cancer progression by CDK4/6 plays a central role in DNA replication and repair pathways. Cancer Res. 2020;: pubmed publisher |
Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, Roedig H, et al. USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination. EMBO Rep. 2021;22:e50163 pubmed publisher |
Ma T, Guo R, Wang X, Shen W, Zhu M, Jin Y, et al. Lentiviral vector with a radiation-inducible promoter, carrying the ING4 gene, mediates radiosensitization controlled by radiotherapy in cervical cancer cells. Oncol Lett. 2021;21:67 pubmed publisher |
Zhang N, Bewick B, Xia G, Furling D, Ashizawa T. A CRISPR-Cas13a Based Strategy That Tracks and Degrades Toxic RNA in Myotonic Dystrophy Type 1. Front Genet. 2020;11:594576 pubmed publisher |
Meng H, Ding Y, Liu E, Li W, Wang L. ZG16 regulates PD-L1 expression and promotes local immunity in colon cancer. Transl Oncol. 2021;14:101003 pubmed publisher |
Luo Y, Schofield J, Na Z, Hann T, Simon M, Slavoff S. Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor. Cell Chem Biol. 2020;: pubmed publisher |
Srivastava S, Furlan S, Jaeger Ruckstuhl C, Sarvothama M, Berger C, Smythe K, et al. Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade. Cancer Cell. 2021;39:193-208.e10 pubmed publisher |
Jia X, Burugula B, Chen V, Lemons R, Jayakody S, Maksutova M, et al. Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Am J Hum Genet. 2021;108:163-175 pubmed publisher |
Aharon Hefetz N, Frumkin I, Mayshar Y, Dahan O, Pilpel Y, Rak R. Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest. elife. 2020;9: pubmed publisher |
Wanuske M, Brantschen D, Schinner C, Stüdle C, Walter E, Hiermaier M, et al. Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion. Acta Physiol (Oxf). 2020;:e13609 pubmed publisher |
Esparza T, Martin N, Anderson G, Goldman E, Brody D. High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme. Sci Rep. 2020;10:22370 pubmed publisher |
Haddad G, Lorenzen J, Ma H, de Haan N, Seeger H, Zaghrini C, et al. Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy. J Clin Invest. 2021;131: pubmed publisher |
Evans L, Anglen T, Scott P, Lukasik K, Loncarek J, Holland A. ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. EMBO J. 2020;:e105106 pubmed publisher |
Burigotto M, Mattivi A, Migliorati D, Magnani G, Valentini C, Roccuzzo M, et al. Centriolar distal appendages activate the centrosome-PIDDosome-p53 signalling axis via ANKRD26. EMBO J. 2021;40:e104844 pubmed publisher |
Hulton C, Costa E, Shah N, Quintanal Villalonga Á, Heller G, de Stanchina E, et al. Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics. Nat Cancer. 2020;1:359-369 pubmed publisher |
Hoffmann H, Schneider W, Rozen Gagnon K, Miles L, Schuster F, Razooky B, et al. TMEM41B Is a Pan-flavivirus Host Factor. Cell. 2021;184:133-148.e20 pubmed publisher |
Humes D, Rainwater S, Overbaugh J. The TOP vector: a new high-titer lentiviral construct for delivery of sgRNAs and transgenes to primary T cells. Mol Ther Methods Clin Dev. 2021;20:30-38 pubmed publisher |
Hu J, Hodgkinson C, Pratt R, Lee J, Sullenger B, Dzau V. Enhancing cardiac reprogramming via synthetic RNA oligonucleotides. Mol Ther Nucleic Acids. 2021;23:55-62 pubmed publisher |
He X, Kim J, Diaz Martinez L, Han C, Lane W, Budnik B, et al. USP13 interacts with cohesin and regulates its ubiquitination in human cells. J Biol Chem. 2021;296:100194 pubmed publisher |
Xu B, Siehr A, Shen W. Functional skeletal muscle constructs from transdifferentiated human fibroblasts. Sci Rep. 2020;10:22047 pubmed publisher |
Iwata S, Morikawa M, Takei Y, Hirokawa N. An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility. Sci Adv. 2020;6: pubmed publisher |
Neggers J, Paolella B, Asfaw A, Rothberg M, Skipper T, Yang A, et al. Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q. Cell Rep. 2020;33:108493 pubmed publisher |
Fujita R, Jamet S, Lean G, Cheng H, Hebert S, Kleinman C, et al. Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation. Development. 2021;148: pubmed publisher |
Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy R, et al. The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Nat Commun. 2020;11:6348 pubmed publisher |
Wang J, Dang M, Day E. Inhibition of Wnt signaling by Frizzled7 antibody-coated nanoshells sensitizes triple-negative breast cancer cells to the autophagy regulator chloroquine. Nano Res. 2020;13:1693-1703 pubmed publisher |
Xiang Y, Li X, Zhan Z, Feng J, Cai H, Li Y, et al. A Novel Nonsense GLI3 Variant Is Associated With Polydactyly and Syndactyly in a Family by Blocking the Sonic Hedgehog Signaling Pathway. Front Genet. 2020;11:542004 pubmed publisher |
Luo W, Garcia Gonzalez I, Fernández Chacón M, Casquero García V, Sanchez Muñoz M, Mühleder S, et al. Arterialization requires the timely suppression of cell growth. Nature. 2021;589:437-441 pubmed publisher |
Wang C, Zhang L, Ke L, Ding W, Jiang S, Li D, et al. Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors. Nat Commun. 2020;11:6318 pubmed publisher |
Liao Q, Mao Y, He H, Ding X, Zhang X, Xu J. PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo. Biomark Res. 2020;8:57 pubmed publisher |
Adam R, van Neerven S, Pleguezuelos Manzano C, Simmini S, Léveillé N, de Groot N, et al. Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development. Cancer Cell Int. 2020;20:578 pubmed publisher |
Velazquez J, LeGraw R, Moghadam F, Tan Y, Kilbourne J, Maggiore J, et al. Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids. Cell Syst. 2021;12:41-55.e11 pubmed publisher |
Maier B, Lorenzen S, Finger A, Herzel H, Kramer A. Searching Novel Clock Genes Using RNAi-Based Screening. Methods Mol Biol. 2021;2130:103-114 pubmed publisher |
Du N, Brown S. Measuring Circadian Rhythms in Human Cells. Methods Mol Biol. 2021;2130:53-67 pubmed publisher |
Fukuda Y, Pazyra Murphy M, Silagi E, Tasdemir Yilmaz O, Li Y, Rose L, et al. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. J Cell Biol. 2021;220: pubmed publisher |
Findakly S, Daggubati V, Garcia G, LaStella S, Choudhury A, Tran C, et al. Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway. J Cell Biol. 2021;220: pubmed publisher |
Jin Y, Sun X, Pei F, Zhao Z, Mao J. Wnt16 signaling promotes osteoblast differentiation of periosteal derived cells in vitro and in vivo. Peerj. 2020;8:e10374 pubmed publisher |
Pajovic S, Siddaway R, Bridge T, Sheth J, Rakopoulos P, Kim B, et al. Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer. Nat Commun. 2020;11:6216 pubmed publisher |
Hsieh A, Pitarresi J, Lerner J, Donahue G, Hsiehchen D, Rustgi A, et al. Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Sci Adv. 2020;6: pubmed publisher |
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher |
Drijvers J, Gillis J, Muijlwijk T, Nguyen T, Gaudiano E, Harris I, et al. Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells. Cancer Immunol Res. 2021;9:184-199 pubmed publisher |
Ma X, Zou F, Yu F, Li R, Yuan Y, Zhang Y, et al. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity. 2020;53:1315-1330.e9 pubmed publisher |
Ribeiro Reily Rocha C, Reily Rocha A, Molina Silva M, Rodrigues Gomes L, Teatin Latancia M, Andrade Tomaz M, et al. Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries. Cells. 2020;9: pubmed publisher |
Dersh D, Phelan J, Gumina M, Wang B, Arbuckle J, Hollý J, et al. Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas. Immunity. 2021;54:116-131.e10 pubmed publisher |
Soares F, Chen B, Lee J, Ahmed M, Ly D, Tin E, et al. CRISPR screen identifies genes that sensitize AML cells to double negative T cell therapy. Blood. 2020;: pubmed publisher |
Shi Y, Stornetta D, Reklow R, Sahu A, Wabara Y, Nguyen A, et al. A brainstem peptide system activated at birth protects postnatal breathing. Nature. 2021;589:426-430 pubmed publisher |
Black J, McCutcheon S, Dube S, Barrera A, Klann T, Rice G, et al. Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens. Cell Rep. 2020;33:108460 pubmed publisher |
Simion V, Zhou H, Haemmig S, Pierce J, Mendes S, Tesmenitsky Y, et al. A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Nat Commun. 2020;11:6135 pubmed publisher |
Alves M, Kodama M, da Silva E, Gomes B, da Silva R, Vieira G, et al. Relative expression of KLK5 to LEKTI is associated with aggressiveness of oral squamous cell carcinoma. Transl Oncol. 2021;14:100970 pubmed publisher |
Ye C, Liu B, Lu H, Liu J, Rabson A, Jacinto E, et al. BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. Nucleic Acids Res. 2020;48:12817-12832 pubmed publisher |
Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, et al. Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1. Sci Signal. 2020;13: pubmed publisher |
Groves N, Bruns M, Van Engelenburg S. A Quantitative Live-Cell Superresolution Imaging Framework for Measuring the Mobility of Single Molecules at Sites of Virus Assembly. Pathogens. 2020;9: pubmed publisher |
Bakhshandeh S, Taïeb H, Schlüßler R, Kim K, Beck T, Taubenberger A, et al. Optical quantification of intracellular mass density and cell mechanics in 3D mechanical confinement. Soft Matter. 2021;17:853-862 pubmed publisher |
Chatterjee P, Ponnapati M, Kramme C, Pleşa A, Church G, Jacobson J. Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Commun Biol. 2020;3:715 pubmed publisher |
Henkel L, Rauscher B, Schmitt B, Winter J, Boutros M. Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library. BMC Biol. 2020;18:174 pubmed publisher |
Shao Z, Cevallos R, Hu K. Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells Using the GFP-Marked Lentiviral Vectors in the Chemically Defined Medium. Methods Mol Biol. 2021;2239:101-116 pubmed publisher |
Ohnstad A, Delgado J, North B, Nasa I, Kettenbach A, Schultz S, et al. Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy. EMBO J. 2020;:e104948 pubmed publisher |
Yang L, Zhang Z, Sun Y, Pang S, Yao Q, Lin P, et al. Integrative analysis reveals novel driver genes and molecular subclasses of hepatocellular carcinoma. Aging (Albany NY). 2020;12:23849-23871 pubmed publisher |
Chai G, Webb A, Li C, Antaki D, Lee S, Breuss M, et al. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021;109:241-256.e9 pubmed publisher |
Milewska A, Chi Y, Szczepanski A, Barreto Durán E, Dabrowska A, Botwina P, et al. HTCC as a Polymeric Inhibitor of SARS-CoV-2 and MERS-CoV. J Virol. 2021;95: pubmed publisher |
Kim S, MacDonald J, Dick F. Phosphorylation of the RB C-terminus regulates condensin II release from chromatin. J Biol Chem. 2021;296:100108 pubmed publisher |
Sun H, Zhu A, Gao Y, Terajima H, Fei Q, Liu S, et al. Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation. Mol Cell. 2020;80:633-647.e7 pubmed publisher |
Zhou M, Kamarshi V, Arvin A, Oliver S. Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion. PLoS Pathog. 2020;16:e1009022 pubmed publisher |
Su W, Chapman N, Wei J, Zeng H, Dhungana Y, Shi H, et al. Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells. Cell Metab. 2020;32:996-1011.e7 pubmed publisher |
Wu J, Krchma K, Lee H, Prabhakar S, Wang X, Zhao H, et al. Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. Cell Rep. 2020;33:108395 pubmed publisher |
Bosakova M, Abraham S, Nita A, Hruba E, Buchtová M, Taylor S, et al. Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling. EMBO Mol Med. 2020;12:e11739 pubmed publisher |
Tomasich E, Topakian T, Heller G, Udovica S, Krainer M, Marhold M. Loss of HCRP1 leads to upregulation of PD-L1 via STAT3 activation and is of prognostic significance in EGFR-dependent cancer. Transl Res. 2021;230:21-33 pubmed publisher |
Kimura Y, Iwanaga E, Iwanaga K, Endo S, Inoue Y, Tokunaga K, et al. A regulatory element in the 3'-untranslated region of CEBPA is associated with myeloid/NK/T-cell leukemia. Eur J Haematol. 2021;106:327-339 pubmed publisher |
Kerek E, Yoon K, Luo S, Chen J, Valencia R, Julien O, et al. A conserved acetylation switch enables pharmacological control of tubby-like protein stability. J Biol Chem. 2021;296:100073 pubmed publisher |
Voss T, Gerget M, Linkus B, von Einem B, Landwehrmeyer G, Lewerenz J. Ubiquitination and the proteasome rather than caspase-3-mediated C-terminal cleavage are involved in the EAAT2 degradation by staurosporine-induced cellular stress. J Neurochem. 2020;: pubmed publisher |
Sapoznik E, Chang B, Huh J, Ju R, Azarova E, Pohlkamp T, et al. A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics. elife. 2020;9: pubmed publisher |
Petitjean O, Girardi E, Ngondo R, Lupashin V, Pfeffer S. Genome-Wide CRISPR-Cas9 Screen Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection. mSphere. 2020;5: pubmed publisher |
Kuan M, Jaeger H, Balemba O, O Dowd J, Duricka D, Hannemann H, et al. Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1. J Virol. 2021;95: pubmed publisher |
Kuppe C, Ibrahim M, Kranz J, Zhang X, Ziegler S, Perales Paton J, et al. Decoding myofibroblast origins in human kidney fibrosis. Nature. 2021;589:281-286 pubmed publisher |
Jones R, Qian Y, Siciliano V, DiAndreth B, Huh J, Weiss R, et al. An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells. Nat Commun. 2020;11:5690 pubmed publisher |
Glorieux C, Xia X, He Y, Hu Y, Cremer K, Robert A, et al. Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling. Redox Biol. 2021;38:101780 pubmed publisher |
Ulukan B, Bihorac A, Sipahioglu T, Kiraly R, Fesus L, Telci D. Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression. ACS Omega. 2020;5:28273-28284 pubmed publisher |
Huang Y, Lin L, Shen Z, Li Y, Cao H, Peng L, et al. CEBPG promotes esophageal squamous cell carcinoma progression by enhancing PI3K-AKT signaling. Am J Cancer Res. 2020;10:3328-3344 pubmed |
Edick A, Audette J, Burgos S. CRISPR-Cas9-mediated knockout of GCN2 reveals a critical role in sensing amino acid deprivation in bovine mammary epithelial cells. J Dairy Sci. 2021;104:1123-1135 pubmed publisher |
Iyer S, Zhang S, Yucel S, Horn H, Smith S, Reinhardt F, et al. Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy. Cancer Discov. 2021;11:384-407 pubmed publisher |
Deol K, Crowe S, Du J, Bisbee H, Guenette R, Strieter E. Proteasome-Bound UCH37/UCHL5 Debranches Ubiquitin Chains to Promote Degradation. Mol Cell. 2020;80:796-809.e9 pubmed publisher |
Tandon R, Mitra D, Sharma P, McCandless M, Stray S, Bates J, et al. Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein. Sci Rep. 2020;10:19076 pubmed publisher |
Oo J, Irmer B, Günther S, Warwick T, Palfi K, Izquierdo Ponce J, et al. ZNF354C is a transcriptional repressor that inhibits endothelial angiogenic sprouting. Sci Rep. 2020;10:19079 pubmed publisher |
Daniloski Z, Jordan T, Wessels H, Hoagland D, Kasela S, Legut M, et al. Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Cell. 2021;184:92-105.e16 pubmed publisher |
Wei J, Alfajaro M, DeWeirdt P, Hanna R, Lu Culligan W, Cai W, et al. Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. Cell. 2021;184:76-91.e13 pubmed publisher |
Zhao D, Zhang L, Zhang M, Xia B, Lv J, Gao X, et al. Broad genic repression domains signify enhanced silencing of oncogenes. Nat Commun. 2020;11:5560 pubmed publisher |
Deng Y, Xia J, Xu Y. Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis. Anticancer Drugs. 2021;32:44-52 pubmed publisher |
Ripperger T, Uhrlaub J, Watanabe M, Wong R, Castaneda Y, Pizzato H, et al. Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low-Prevalence Communities and Reveal Durable Humoral Immunity. Immunity. 2020;53:925-933.e4 pubmed publisher |
Francescone R, Barbosa Vendramini Costa D, Franco Barraza J, Wagner J, Muir A, Lau A, et al. Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. Cancer Discov. 2021;11:446-479 pubmed publisher |
Ophinni Y, Miki S, Hayashi Y, Kameoka M. Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape. Viruses. 2020;12: pubmed publisher |
Ogrodzinski M, Teoh S, Lunt S. Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model. Cancer Res. 2021;81:303-314 pubmed publisher |
Zielke S, Kardo S, Zein L, Mari M, Covarrubias Pinto A, Kinzler M, et al. ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy. 2020;:1-17 pubmed publisher |
Siwek W, Tehrani S, Mata J, Jansen L. Activation of Clustered IFNγ Target Genes Drives Cohesin-Controlled Transcriptional Memory. Mol Cell. 2020;80:396-409.e6 pubmed publisher |
Zhang W, Tao S, Wang T, Zhang J, Liu X, Li Y, et al. ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. FEBS Lett. 2021;595:169-182 pubmed publisher |
Terai H, Hamamoto J, Emoto K, Masuda T, Manabe T, Kuronuma S, et al. SHOC2 Is a Critical Modulator of Sensitivity to EGFR-TKIs in Non-Small Cell Lung Cancer Cells. Mol Cancer Res. 2021;19:317-328 pubmed publisher |
García de Gracia F, Gaete Argel A, Riquelme Barrios S, Pereira Montecinos C, Rojas Araya B, Aguilera P, et al. CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev. RNA Biol. 2021;18:745-758 pubmed publisher |
Ruiz Rodado V, Lita A, Dowdy T, Celiku O, Saldana A, Wang H, et al. Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition. Cancer Metab. 2020;8:23 pubmed publisher |
Clark P, Gee G, Albright B, Assetta B, Han Y, Atwood W, et al. Phosphoinositide 3'-Kinase γ Facilitates Polyomavirus Infection. Viruses. 2020;12: pubmed publisher |
Barua D, Abbasi B, Gupta A, Gupta S. XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation. Heliyon. 2020;6:e05217 pubmed publisher |
Beharier O, Tyurin V, Goff J, Guerrero Santoro J, Kajiwara K, Chu T, et al. PLA2G6 guards placental trophoblasts against ferroptotic injury. Proc Natl Acad Sci U S A. 2020;117:27319-27328 pubmed publisher |
Maitituoheti M, Keung E, Tang M, Yan L, Alam H, Han G, et al. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Rep. 2020;33:108293 pubmed publisher |
Oulès B, Philippeos C, Segal J, Tihy M, Vietri Rudan M, Cujba A, et al. Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Nat Commun. 2020;11:5067 pubmed publisher |
Franco A, Dang X, Walton E, Ho J, Zablocka B, Ly C, et al. Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A. elife. 2020;9: pubmed publisher |
Ming S, Zeng L, Guo Y, Zhang S, Li G, Ma Y, et al. The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells. Front Immunol. 2020;11:575818 pubmed publisher |
Chuang T, Rehan A, Khorram O. Functional role of the long noncoding RNA X-inactive specific transcript in leiomyoma pathogenesis. Fertil Steril. 2021;115:238-247 pubmed publisher |
Whaley R, Ameny S, Arkatkar T, Seese A, Wall A, Khan I, et al. Generation of a cost-effective cell line for support of high-throughput isolation of primary human B cells and monoclonal neutralizing antibodies. J Immunol Methods. 2021;488:112901 pubmed publisher |
Sreevalsan S, Döring M, Paszkowski Rogacz M, Brux M, Blanck C, Meyer M, et al. MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. EMBO Rep. 2020;:e50155 pubmed publisher |
Borgoni S, Sofyalı E, Soleimani M, Wilhelm H, Muller Decker K, Will R, et al. Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer. Cancers (Basel). 2020;12: pubmed publisher |
Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima Takagi Y, et al. Efficacy of the novel tubulin polymerization inhibitor PTC-028 for myelodysplastic syndrome. Cancer Sci. 2020;111:4336-4347 pubmed publisher |
Papathanasiou M, Tsiftsoglou S, Polyzos A, Papadopoulou D, Valakos D, Klagkou E, et al. Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes. EMBO J. 2021;40:e102236 pubmed publisher |
Martinez Lage M, Torres Ruiz R, Puig Serra P, Moreno Gaona P, Martin M, Moya F, et al. In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells. Nat Commun. 2020;11:5060 pubmed publisher |
Hollinshead K, Parker S, Eapen V, Encarnación Rosado J, Sohn A, Oncu T, et al. Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer. Cell Rep. 2020;33:108231 pubmed publisher |
Dean J, He A, Tan M, Wang J, Lu D, Razani B, et al. MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression. Cell Rep. 2020;33:108228 pubmed publisher |
Aguadé Gorgorió J, McComb S, Eckert C, Guinot A, Marovca B, Mezzatesta C, et al. TNFR2 is required for RIP1-dependent cell death in human leukemia. Blood Adv. 2020;4:4823-4833 pubmed publisher |
Kim H, Cho Y, Kim H, Kang D, Cheon D, Kim Y, et al. A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nat Commun. 2020;11:5023 pubmed publisher |
Bhushan J, Radke J, Perng Y, McAllaster M, Lenschow D, Virgin H, et al. ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells. MBio. 2020;11: pubmed publisher |
Molinuevo R, Freije A, Contreras L, Sanz J, Gandarillas A. The DNA damage response links human squamous proliferation with differentiation. J Cell Biol. 2020;219: pubmed publisher |
Choi E, Palacios Prado N, Saez J, Lee J. Identification of Cx45 as a Major Component of GJs in HeLa Cells. Biomolecules. 2020;10: pubmed publisher |
Rodriguez A, Zhang K, Färkkilä A, Filiatrault J, Yang C, Velázquez M, et al. MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia. Cell Stem Cell. 2021;28:33-47.e8 pubmed publisher |
Ramadurgum P, Hulleman J. Protocol for Designing Small-Molecule-Regulated Destabilizing Domains for In Vitro Use. STAR Protoc. 2020;1: pubmed publisher |
Yurkovetskiy L, Wang X, Pascal K, Tomkins Tinch C, Nyalile T, Wang Y, et al. Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. Cell. 2020;183:739-751.e8 pubmed publisher |
Hiraike Y, Waki H, Miyake K, Wada T, Oguchi M, Saito K, et al. NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation. PLoS Genet. 2020;16:e1009044 pubmed publisher |
Guo H, Zhu J, Miao Q, Qi R, Tang A, Liu C, et al. RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication. Vet Microbiol. 2020;249:108858 pubmed publisher |
Bindschedler A, Wacker R, Egli J, Eickel N, Schmuckli Maurer J, Franke Fayard B, et al. Plasmodium berghei sporozoites in nonreplicative vacuole are eliminated by a PI3P-mediated autophagy-independent pathway. Cell Microbiol. 2021;23:e13271 pubmed publisher |
Fujimura A, Yasui S, Igawa K, Ueda A, Watanabe K, Hanafusa T, et al. In Vitro Studies to Define the Cell-Surface and Intracellular Targets of Polyarginine-Conjugated Sodium Borocaptate as a Potential Delivery Agent for Boron Neutron Capture Therapy. Cells. 2020;9: pubmed publisher |
Gabitova Cornell L, Surumbayeva A, Peri S, Franco Barraza J, Restifo D, Weitz N, et al. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell. 2020;38:567-583.e11 pubmed publisher |
Prunet A, Lefort S, Delanoë Ayari H, Laperrousaz B, Simon G, Barentin C, et al. A new agarose-based microsystem to investigate cell response to prolonged confinement. Lab Chip. 2020;20:4016-4030 pubmed publisher |
Li Y, Ivica N, Dong T, Papageorgiou D, He Y, Brown D, et al. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nat Commun. 2020;11:4837 pubmed publisher |
Kim K, Kim Y, Rivard C, Kim D, Park K. FGFR1 Is Critical for RBL2 Loss-Driven Tumor Development and Requires PLCG1 Activation for Continued Growth of Small Cell Lung Cancer. Cancer Res. 2020;80:5051-5062 pubmed publisher |
Clausen T, Sandoval D, Spliid C, Pihl J, Perrett H, Painter C, et al. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Cell. 2020;: pubmed publisher |
Muscarella A, Dai W, Mitchell P, Zhang W, Wang H, Jia L, et al. Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. NPJ Breast Cancer. 2020;6:42 pubmed publisher |
Kuge H, Miyamoto I, Yagyu K, Honke K. PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. J Lipid Res. 2020;61:1747-1763 pubmed publisher |
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, et al. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020;11:4766 pubmed publisher |
Chen V, Moncalvo M, Tringali D, Tagliafierro L, Shriskanda A, Ilich E, et al. The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations. Hum Mol Genet. 2020;29:3107-3121 pubmed publisher |
Carlini V, Gretarsson K, Hackett J. Genome-Scale CRISPR Screening for Regulators of Cell Fate Transitions. Methods Mol Biol. 2021;2214:91-108 pubmed publisher |
Gremke N, Polo P, Dort A, Schneikert J, Elmshäuser S, Brehm C, et al. mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Nat Commun. 2020;11:4684 pubmed publisher |
Magupalli V, Negro R, Tian Y, Hauenstein A, Di Caprio G, Skillern W, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020;369: pubmed publisher |
Rong Z, Gong X, Hulleman J, Corey D, Mootha V. Trinucleotide Repeat-Targeting dCas9 as a Therapeutic Strategy for Fuchs' Endothelial Corneal Dystrophy. Transl Vis Sci Technol. 2020;9:47 pubmed publisher |
Zhang Y, Huang Y, Wang D, Yang B, Yan H, Lin L, et al. LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network. Theranostics. 2020;10:10823-10837 pubmed publisher |
Nalairndran G, Hassan Abdul Razack A, Mai C, Fei Lei Chung F, Chan K, Hii L, et al. Phosphoinositide-dependent Kinase-1 (PDPK1) regulates serum/glucocorticoid-regulated Kinase 3 (SGK3) for prostate cancer cell survival. J Cell Mol Med. 2020;24:12188-12198 pubmed publisher |
Li S, Zhou M, Ze K, Sun X, Zhao C, Li Z, et al. Protective role of histone deacetylase 4 from ultraviolet radiation-induced DNA lesions. Mol Carcinog. 2020;59:1292-1301 pubmed publisher |
Turelli P, Playfoot C, Grun D, Raclot C, Pontis J, Coudray A, et al. Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons. Sci Adv. 2020;6:eaba3200 pubmed publisher |
Santos G, Silva D, Fortuna V, Silveira B, Orge I, de Santana T, et al. Leukemia Inhibitory Factor (LIF) Overexpression Increases the Angiogenic Potential of Bone Marrow Mesenchymal Stem/Stromal Cells. Front Cell Dev Biol. 2020;8:778 pubmed publisher |
Eufrásio A, Perrod C, Ferreira F, Duque M, Galhardo M, Bessa J. In Vivo Reporter Assays Uncover Changes in Enhancer Activity Caused by Type 2 Diabetes-Associated Single Nucleotide Polymorphisms. Diabetes. 2020;69:2794-2805 pubmed publisher |
Yi S, Nam K, Yun J, Gim D, Joe D, Kim Y, et al. Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus. Viruses. 2020;12: pubmed publisher |
Shim J, Lee J, Jonus H, Arnold A, Schnepp R, Janssen K, et al. YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma. Cancer Res. 2020;80:4741-4753 pubmed publisher |
Ferreira Mendes J, de Faro Valverde L, Torres Andion Vidal M, Paredes B, Coelho P, Allahdadi K, et al. Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. Int J Mol Sci. 2020;21: pubmed publisher |
Sakashita A, Maezawa S, Takahashi K, Alavattam K, Yukawa M, Hu Y, et al. Endogenous retroviruses drive species-specific germline transcriptomes in mammals. Nat Struct Mol Biol. 2020;27:967-977 pubmed publisher |
Zhang X, Yu D, Wu Y, Gu T, Ma N, Dong S, et al. Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew. Appl Microbiol Biotechnol. 2020;104:8813-8823 pubmed publisher |
Rogerson C, Ogden S, Britton E, Ang Y, Sharrocks A. Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma. elife. 2020;9: pubmed publisher |
Fiore V, Krajnc M, Quiroz F, Levorse J, Pasolli H, Shvartsman S, et al. Mechanics of a multilayer epithelium instruct tumour architecture and function. Nature. 2020;585:433-439 pubmed publisher |
Yamulla R, Nalubola S, Flesken Nikitin A, Nikitin A, Schimenti J. Most Commonly Mutated Genes in High-Grade Serous Ovarian Carcinoma Are Nonessential for Ovarian Surface Epithelial Stem Cell Transformation. Cell Rep. 2020;32:108086 pubmed publisher |
Zhan H, Bhattacharya S, Cai H, Iglesias P, Huang C, Devreotes P. An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Dev Cell. 2020;54:608-623.e5 pubmed publisher |
Chen C, Enomoto A, Weng L, Taki T, Shiraki Y, Mii S, et al. Complex roles of the actin-binding protein Girdin/GIV in DNA damage-induced apoptosis of cancer cells. Cancer Sci. 2020;111:4303-4317 pubmed publisher |
Peskova L, Jurcikova D, Vanova T, Krivanek J, Capandova M, Srámková Z, et al. miR-183/96/182 cluster is an important morphogenetic factor targeting PAX6 expression in differentiating human retinal organoids. Stem Cells. 2020;: pubmed publisher |
Abe K, Li Z, Samson R, Samavarchi Tehrani P, Valcourt E, Wood H, et al. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020;5: pubmed publisher |
Chen Y, Tao H, Shen S, Miao Z, Li L, Jia Y, et al. A drug screening toolkit based on the -1 ribosomal frameshifting of SARS-CoV-2. Heliyon. 2020;6:e04793 pubmed publisher |
Oliver C, Westerhof T, Castro M, Merajver S. Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography. J Vis Exp. 2020;: pubmed publisher |
Kutukculer N, Seeholzer T, O Neill T, Graß C, Aykut A, Karaca N, et al. Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant. J Allergy Clin Immunol. 2021;147:775-778.e8 pubmed publisher |
Wang B, Jing T, Jin W, Chen J, Wu C, Wang M, et al. KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma. J Exp Clin Cancer Res. 2020;39:170 pubmed publisher |
Stephani M, Picchianti L, Gajic A, Beveridge R, Skarwan E, Sanchez de Medina Hernandez V, et al. A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress. elife. 2020;9: pubmed publisher |
Wang S, Liu Y, Crisman L, Wan C, Miller J, Yu H, et al. Genetic evidence for an inhibitory role of tomosyn in insulin-stimulated GLUT4 exocytosis. Traffic. 2020;21:636-646 pubmed publisher |
Qiu X, Ma F, Zhao M, Cao Y, Shipp L, Liu A, et al. Altered 3D chromatin structure permits inversional recombination at the IgH locus. Sci Adv. 2020;6:eaaz8850 pubmed publisher |
Fiches G, Zhou D, Kong W, Biswas A, Ahmed E, Baiocchi R, et al. Profiling of immune related genes silenced in EBV-positive gastric carcinoma identified novel restriction factors of human gammaherpesviruses. PLoS Pathog. 2020;16:e1008778 pubmed publisher |
Sawangmake C, Rodprasert W, Osathanon T, Pavasant P. Integrative protocols for an in vitro generation of pancreatic progenitors from human dental pulp stem cells. Biochem Biophys Res Commun. 2020;530:222-229 pubmed publisher |
Escoll M, Lastra D, Robledinos Antón N, Wandosell F, Anton I, Cuadrado A. WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells. Antioxidants (Basel). 2020;9: pubmed publisher |
Huang D, Camacho C, Setlem R, Ryu K, Parameswaran B, Gupta R, et al. Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. Mol Cell. 2020;79:934-949.e14 pubmed publisher |
Salzer B, Schueller C, Zajc C, Peters T, Schoeber M, Kovacic B, et al. Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Nat Commun. 2020;11:4166 pubmed publisher |
Cao X, Wolf A, Kim S, Cabrera R, Wlodarczyk B, Zhu H, et al. CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. J Med Genet. 2020;: pubmed publisher |
Chung C, Allen A, Atkins A, Sullivan N, Homan G, Costello R, et al. Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-κB Binding Sites. Mol Ther Nucleic Acids. 2020;21:965-982 pubmed publisher |
Ye F, Xu Y, Lin F, Zheng Z. TNF-α suppresses SHOX2 expression via NF-κB signaling pathway and promotes intervertebral disc degeneration and related pain in a rat model. J Orthop Res. 2020;: pubmed publisher |
Gomes A, Ilter D, Low V, Endress J, Fernández García J, Rosenzweig A, et al. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020;585:283-287 pubmed publisher |
Wang Y, Zhang M, Wang Z, Guo W, Yang D. MYC-binding lncRNA EPIC1 promotes AKT-mTORC1 signaling and rapamycin resistance in breast and ovarian cancer. Mol Carcinog. 2020;59:1188-1198 pubmed publisher |
Carullo N, Phillips Iii R, Simon R, Soto S, Hinds J, Salisbury A, et al. Enhancer RNAs predict enhancer-gene regulatory links and are critical for enhancer function in neuronal systems. Nucleic Acids Res. 2020;48:9550-9570 pubmed publisher |
Lv L, Chen P, Cao L, Li Y, Zeng Z, Cui Y, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. elife. 2020;9: pubmed publisher |
Calderon Aparicio A, Yamamoto H, De Vitto H, Zhang T, Wang Q, Bode A, et al. RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor. Mol Cancer Res. 2020;18:1660-1674 pubmed publisher |
Chien J, Tabet E, Pinkham K, da Hora C, Chang J, Lin S, et al. A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo. Nucleic Acids Res. 2020;48:e100 pubmed publisher |
Cendrowski J, Kaczmarek M, Mazur M, Kuzmicz Kowalska K, Jastrzębski K, Brewińska Olchowik M, et al. Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells. elife. 2020;9: pubmed publisher |
Bogert N, Furkel J, Din S, Braren I, Eckstein V, Muller J, et al. A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus. Sci Rep. 2020;10:13740 pubmed publisher |
Chen M, Maimaitili M, Habekost M, Gill K, Mermet Joret N, Nabavi S, et al. Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells. Stem Cell Res. 2020;48:101945 pubmed publisher |
Dickerson M, Dadi P, Butterworth R, Nakhe A, Graff S, Zaborska K, et al. Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion. J Physiol. 2020;598:4887-4905 pubmed publisher |
Wisniewski E, Mistriotis P, Bera K, Law R, Zhang J, Nikolic M, et al. Dorsoventral polarity directs cell responses to migration track geometries. Sci Adv. 2020;6:eaba6505 pubmed publisher |
Dai H, Liang Z, Chang A, Chapdelaine Williams A, Alvarado B, Pollen A, et al. Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020;15:3154-3181 pubmed publisher |
MacEwen M, Markhard A, Bozbeyoglu M, Bradford F, Goldberger O, Mootha V, et al. Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU. Life Sci Alliance. 2020;3: pubmed publisher |
Müller S, Bley N, Busch B, Glaß M, Lederer M, Misiak C, et al. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer. Nucleic Acids Res. 2020;48:8576-8590 pubmed publisher |
Güllü N, Kobelt D, Brim H, Rahman S, Timm L, Smith J, et al. Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells. Cells. 2020;9: pubmed publisher |
Tastan C, Kançağı D, Turan R, Yurtsever B, Çakırsoy D, Abanuz S, et al. Preclinical Assessment of Efficacy and Safety Analysis of CAR-T Cells (ISIKOK-19) Targeting CD19-Expressing B-Cells for the First Turkish Academic Clinical Trial with Relapsed/Refractory ALL and NHL Patients. Turk J Haematol. 2020;37:234-247 pubmed publisher |
Werley C, Boccardo S, Rigamonti A, Hansson E, Cohen A. Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular physiology. Nat Commun. 2020;11:3881 pubmed publisher |
Mazumdar A, Urdinez J, Boro A, Migliavacca J, Arlt M, Muff R, et al. Osteosarcoma-Derived Extracellular Vesicles Induce Lung Fibroblast Reprogramming. Int J Mol Sci. 2020;21: pubmed publisher |
Mayor Ruiz C, Bauer S, Brand M, Kozicka Z, Siklos M, Imrichová H, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020;: pubmed publisher |
Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, et al. KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. NAR Cancer. 2020;2:zcaa007 pubmed publisher |
Barter M, Cheung K, Falk J, Panagiotopoulos A, Cosimini C, O Brien S, et al. Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation. Epigenetics. 2021;16:106-119 pubmed publisher |
Chen C, Zhu S, Zhang X, Zhou T, Gu J, Xu Y, et al. Targeting the Synthetic Vulnerability of PTEN-Deficient Glioblastoma Cells with MCL1 Inhibitors. Mol Cancer Ther. 2020;19:2001-2011 pubmed publisher |
Ge X, Zhang T, Yu X, Muwonge A, Anandakrishnan N, Wong N, et al. LIM-Nebulette Reinforces Podocyte Structural Integrity by Linking Actin and Vimentin Filaments. J Am Soc Nephrol. 2020;31:2372-2391 pubmed publisher |
Rahmani A, Naderi M, Barati G, Arefian E, Jedari B, Nadri S. The potency of hsa-miR-9-1 overexpression in photoreceptor differentiation of conjunctiva mesenchymal stem cells on a 3D nanofibrous scaffold. Biochem Biophys Res Commun. 2020;529:526-532 pubmed publisher |
Frazier H, Ghoweri A, Anderson K, Lin R, Popa G, Mendenhall M, et al. Elevating Insulin Signaling Using a Constitutively Active Insulin Receptor Increases Glucose Metabolism and Expression of GLUT3 in Hippocampal Neurons. Front Neurosci. 2020;14:668 pubmed publisher |
Cone A, Hurwitz S, Lee G, Yuan X, Zhou Y, Li Y, et al. Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. BMC Mol Cell Biol. 2020;21:58 pubmed publisher |
Garbutt T, Zhou Y, Keepers B, Liu J, Qian L. An Optimized Protocol for Human Direct Cardiac Reprogramming. STAR Protoc. 2020;1: pubmed publisher |
Smith H, Yang L, Ling C, Walsh A, Martinez V, Boucher J, et al. An ErbB2 splice variant lacking exon 16 drives lung carcinoma. Proc Natl Acad Sci U S A. 2020;117:20139-20148 pubmed publisher |
Foltz L, Palacios Moreno J, Mayfield M, Kinch S, Dillon J, Syrenne J, et al. PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation. Mol Biol Cell. 2020;31:2269-2282 pubmed publisher |
Gao Y, Luo T, Ouyang X, Zhu C, Zhu J, Qin X. IGF2BP3 and miR191-5p synergistically increase HCC cell invasiveness by altering ZO-1 expression. Oncol Lett. 2020;20:1423-1431 pubmed publisher |
Massenet J, Gitiaux C, Magnan M, Cuvellier S, Hubas A, Nusbaum P, et al. Derivation and Characterization of Immortalized Human Muscle Satellite Cell Clones from Muscular Dystrophy Patients and Healthy Individuals. Cells. 2020;9: pubmed publisher |
Zhai B, Li Y, Kotapalli S, Bacha J, Brown D, Steinø A, et al. Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells. Cell Death Dis. 2020;11:577 pubmed publisher |
Cambria E, Arlt M, Wandel S, Krupkova O, Hitzl W, Passini F, et al. TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells. Cells. 2020;9: pubmed publisher |
Miyabayashi K, Baker L, Deschênes A, Traub B, Caligiuri G, Plenker D, et al. Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes. Cancer Discov. 2020;10:1566-1589 pubmed publisher |
Hinze L, Labrosse R, Degar J, Han T, Schatoff E, Schreek S, et al. Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. Cancer Discov. 2020;: pubmed publisher |
Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, et al. The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest. 2020;: pubmed publisher |
Clausen T, Sandoval D, Spliid C, Pihl J, Painter C, Thacker B, et al. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. bioRxiv. 2020;: pubmed publisher |
Sharon D, Nesdoly S, Yang H, Gélinas J, Xia Y, Ansorge S, et al. A pooled genome-wide screening strategy to identify and rank influenza host restriction factors in cell-based vaccine production platforms. Sci Rep. 2020;10:12166 pubmed publisher |
Ludwik K, Sandusky Z, Stauffer K, Li Y, Boyd K, O Doherty G, et al. RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha. Cell Rep. 2020;32:107931 pubmed publisher |
Khalil W, Tiraihi T, Soleimani M, Baheiraei N, Zibara K. Conversion of Neural Stem Cells into Functional Neuron-Like Cells by MicroRNA-218: Differential Expression of Functionality Genes. Neurotox Res. 2020;: pubmed publisher |
Trümper V, Wittig I, Heidler J, Richter F, Brüne B, von Knethen A. Redox Regulation of PPARγ in Polarized Macrophages. PPAR Res. 2020;2020:8253831 pubmed publisher |
Alladin A, Chaible L, Garcia Del Valle L, Sabine R, Loeschinger M, Wachsmuth M, et al. Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation. elife. 2020;9: pubmed publisher |
Farhat T, Dudakovic A, Chung J, Van Wijnen A, St Arnaud R. Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses. J Cell Physiol. 2020;: pubmed publisher |
Yang M, Tang X, Zhang Z, Gu L, Wei H, Zhao S, et al. Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. Theranostics. 2020;10:7622-7634 pubmed publisher |
Stojic L. Tuning the Expression of Long Noncoding RNA Loci with CRISPR Interference. Methods Mol Biol. 2020;2161:1-16 pubmed publisher |
Walavalkar K, Saravanan B, Singh A, Jayani R, Nair A, Farooq U, et al. A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer. Nat Commun. 2020;11:3598 pubmed publisher |
Xiang Q, Wan P, Yang G, Huang S, Qin M, Yang H, et al. Beclin1 Binds to Enterovirus 71 3D Protein to Promote the Virus Replication. Viruses. 2020;12: pubmed publisher |
Pinkert S, Kopp A, Brückner V, Fechner H, Beling A. Single point mutations within the Coxsackie B virus receptor-binding site promote resistance against soluble virus receptor traps. J Virol. 2020;: pubmed publisher |
Eyler C, Matsunaga H, Hovestadt V, Vantine S, van Galen P, Bernstein B. Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance. Genome Biol. 2020;21:174 pubmed publisher |
Bouchareychas L, Duong P, Covarrubias S, Alsop E, Phu T, Chung A, et al. Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo. Cell Rep. 2020;32:107881 pubmed publisher |
Zhu X, Zhang H, Mendell J. Ribosome Recycling by ABCE1 Links Lysosomal Function and Iron Homeostasis to 3' UTR-Directed Regulation and Nonsense-Mediated Decay. Cell Rep. 2020;32:107895 pubmed publisher |
Francis A, Marin M, Singh P, Achuthan V, Prellberg M, Palermino Rowland K, et al. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020;11:3505 pubmed publisher |
DeWeirdt P, Sanson K, Sangree A, Hegde M, Hanna R, Feeley M, et al. Optimization of AsCas12a for combinatorial genetic screens in human cells. Nat Biotechnol. 2020;: pubmed publisher |
Gier R, Budinich K, Evitt N, Cao Z, Freilich E, Chen Q, et al. High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening. Nat Commun. 2020;11:3455 pubmed publisher |
Jiang M, Volland S, Paniagua A, Wang H, Balaji A, Li D, et al. Microtubule motor transport in the delivery of melanosomes to the actin-rich, apical domain of in the retinal pigment epithelium. J Cell Sci. 2020;: pubmed publisher |
Tsang A, Koch C, Kiehn J, Schmidt C, Oster H. An adipokine feedback regulating diurnal food intake rhythms in mice. elife. 2020;9: pubmed publisher |
Gordon M, Inoue F, Martin B, Schubach M, Agarwal V, Whalen S, et al. lentiMPRA and MPRAflow for high-throughput functional characterization of gene regulatory elements. Nat Protoc. 2020;: pubmed publisher |
Alda Catalinas C, Bredikhin D, Hernando Herraez I, Santos F, Kubinyecz O, Eckersley Maslin M, et al. A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program. Cell Syst. 2020;11:25-41.e9 pubmed publisher |
Maziarz M, Park J, Leyme A, Marivin A, Garcia Lopez A, Patel P, et al. Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design. Cell. 2020;: pubmed publisher |
Zhao G, Kim E, Jiang J, Bhoot C, Charles K, Baek J, et al. CCN1/Cyr61 is required in osteoblasts for responsiveness to the anabolic activity of PTH. J Bone Miner Res. 2020;: pubmed publisher |
Demirkol Canlı S, Seza E, Sheraj I, Gomceli I, Turhan N, Carberry S, et al. Evaluation of an aldo-keto reductase gene signature with prognostic significance in colon cancer via activation of epithelial to mesenchymal transition and the p70S6K pathway. Carcinogenesis. 2020;: pubmed publisher |
Zhang X, Fan X, Li F, Qiu J, Zhang Y. Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. Mol Med Rep. 2020;22:1391-1399 pubmed publisher |
Yang G, Dong K, Zhang Z, Zhang E, Liang B, Chen X, et al. EXO1 Plays a Carcinogenic Role in Hepatocellular Carcinoma and is related to the regulation of FOXP3. J Cancer. 2020;11:4917-4932 pubmed publisher |
Indiková I, Indik S. Highly efficient 'hit-and-run' genome editing with unconcentrated lentivectors carrying Vpr.Prot.Cas9 protein produced from RRE-containing transcripts. Nucleic Acids Res. 2020;: pubmed publisher |
Guan X, Zhang H, Qin H, Chen C, Hu Z, Tan J, et al. CRISPR/Cas9-mediated whole genomic wide knockout screening identifies mitochondrial ribosomal proteins involving in oxygen-glucose deprivation/reperfusion resistance. J Cell Mol Med. 2020;: pubmed publisher |
Brownmiller T, Juric J, Ivey A, Harvey B, Westemeier E, Winters M, et al. Y Chromosome LncRNA are involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells. Cancer Res. 2020;: pubmed publisher |
Budková Z, Sigurdardottir A, Briem E, Bergthorsson J, Sigurdsson S, Magnusson M, et al. Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells. Front Cell Dev Biol. 2020;8:461 pubmed publisher |
Sato T, Verma S, Andrade C, Omeara M, Campbell N, Wang J, et al. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Nat Commun. 2020;11:3282 pubmed publisher |
Zhan Y, Yu S, Yang S, Qiu X, Meng C, Tan L, et al. Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E. PLoS Pathog. 2020;16:e1008610 pubmed publisher |
Müller S, Perdikari A, Dapito D, Sun W, Wollscheid B, Balaz M, et al. ESRRG and PERM1 Govern Mitochondrial Conversion in Brite/Beige Adipocyte Formation. Front Endocrinol (Lausanne). 2020;11:387 pubmed publisher |
Inoue A, Nakao Kuroishi K, Kometani Gunjigake K, Mizuhara M, Shirakawa T, Ito Sago M, et al. VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation. FEBS Open Bio. 2020;: pubmed publisher |
Daniloski Z, Guo X, Sanjana N. The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types. bioRxiv. 2020;: pubmed publisher |
Tandon R, Sharp J, Zhang F, Pomin V, Ashpole N, Mitra D, et al. Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives. bioRxiv. 2020;: pubmed publisher |
Lu C, Fang S, Weng Q, Lv X, Meng M, Zhu J, et al. Integrated analysis reveals critical glycolytic regulators in hepatocellular carcinoma. Cell Commun Signal. 2020;18:97 pubmed publisher |
Gratacap R, Regan T, Dehler C, Martin S, Boudinot P, Collet B, et al. Efficient CRISPR/Cas9 genome editing in a salmonid fish cell line using a lentivirus delivery system. BMC Biotechnol. 2020;20:35 pubmed publisher |
Škerlová J, Unterlass J, Göttmann M, Marttila P, Homan E, Helleday T, et al. Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. J Biol Chem. 2020;: pubmed publisher |
Lee H, Lee H, Lee B, Gerovska D, Park S, Zaehres H, et al. Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model. elife. 2020;9: pubmed publisher |
Sharma S, Wright G. Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens. J Vis Exp. 2020;: pubmed publisher |
Liao J, Zhou G, Zhou Y. Generation of Monoclonal iPSC Lines with Stable Cas9 Expression and High Cas9 Activity. Methods Mol Biol. 2020;: pubmed publisher |
Hoekstra M, Bornes L, Dijkgraaf F, Philips D, Pardieck I, Toebes M, et al. Long-distance modulation of bystander tumor cells by CD8+ T cell-secreted IFNγ. Nat Cancer. 2020;1:291-301 pubmed publisher |
van de Ven C, Boeree A, Stalpers F, Zwaan C, den Boer M. Ibrutinib is not an effective drug in primografts of TCF3-PBX1. Transl Oncol. 2020;13:100817 pubmed publisher |
Shi C, Zhu Y, Bruins L, Bonolo de Campos C, Stewart W, Braggio E, et al. Proteasome subunits differentially control Myeloma cell viability and proteasome inhibitor sensitivity. Mol Cancer Res. 2020;: pubmed publisher |
Yang Y, Huang X, Ma G, Cui J, Matsubara J, Kazlauskas A, et al. PDGFRβ plays an essential role in patient vitreous-stimulated contraction of retinal pigment epithelial cells from epiretinal membranes. Exp Eye Res. 2020;197:108116 pubmed publisher |
Jasmer K, Hou J, Mannino P, Cheng J, Hannink M. Heme oxygenase promotes B-Raf-dependent melanosphere formation. Pigment Cell Melanoma Res. 2020;: pubmed publisher |
Schnormeier A, Pommerenke C, Kaufmann M, Drexler H, Koeppel M. Genomic deregulation of PRMT5 supports growth and stress tolerance in chronic lymphocytic leukemia. Sci Rep. 2020;10:9775 pubmed publisher |
Zajc C, Dobersberger M, Schaffner I, Mlynek G, Pühringer D, Salzer B, et al. A conformation-specific ON-switch for controlling CAR T cells with an orally available drug. Proc Natl Acad Sci U S A. 2020;117:14926-14935 pubmed publisher |
Nkosi D, Sun L, Duke L, Patel N, Surapaneni S, Singh M, et al. Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. MBio. 2020;11: pubmed publisher |
Cai C, Yang C, Zhuang X, Yuan N, Wu M, Tan J, et al. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2020;:1-19 pubmed publisher |
Wandel M, Kim B, Park E, Boyle K, Nayak K, Lagrange B, et al. Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nat Immunol. 2020;21:880-891 pubmed publisher |
Howe E, Burnette M, Justice M, Schnepp P, Hedrick V, Clancy J, et al. Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. Nat Commun. 2020;11:3017 pubmed publisher |
Ho E, Tsai A, Stearns T. Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control. Curr Biol. 2020;30:2829-2835.e5 pubmed publisher |
Su R, Dong L, Li Y, Gao M, Han L, Wunderlich M, et al. Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion. Cancer Cell. 2020;38:79-96.e11 pubmed publisher |
Alix E, Godlee C, Cerny O, Blundell S, Tocci R, Matthews S, et al. The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules. Cell Host Microbe. 2020;28:54-68.e7 pubmed publisher |
Xie L, Hu W, Hu D, Shi G, Li Y, Yang J, et al. Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Environ Health Perspect. 2020;128:67008 pubmed publisher |
Sasaki Y. Viral Transduction of DRG Neurons. Methods Mol Biol. 2020;2143:55-62 pubmed publisher |
Wessels H, Méndez Mancilla A, Guo X, Legut M, Daniloski Z, Sanjana N. Massively parallel Cas13 screens reveal principles for guide RNA design. Nat Biotechnol. 2020;38:722-727 pubmed publisher |
lvarez Quil n A, Wojtaszek J, Mathieu M, Patel T, Appel C, Hustedt N, et al. Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Mol Cell. 2020;78:1152-1165.e8 pubmed publisher |
Cai E, Kufeld M, Schuster S, Arora S, Larkin M, Germanos A, et al. Selective Translation of Cell Fate Regulators Mediates Tolerance to Broad Oncogenic Stress. Cell Stem Cell. 2020;: pubmed publisher |
Moreno Delgado D, Puigdellívol M, Moreno E, Rodríguez Ruiz M, Botta J, Gasperini P, et al. Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease. elife. 2020;9: pubmed publisher |
Song Q, Ni K, Liu M, Li Y, Wang L, Wang Y, et al. Direct-seq: programmed gRNA scaffold for streamlined scRNA-seq in CRISPR screen. Genome Biol. 2020;21:136 pubmed publisher |
Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, et al. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020;11:483-504 pubmed publisher |
Swaminathan S, Hansen A, Heftdal L, Dhanasekaran R, Deutzmann A, Fernandez W, et al. MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies. Nat Commun. 2020;11:2860 pubmed publisher |
Yu L, Wang L, Kim J, Mao C, Shapiro D. Src couples estrogen receptor to the anticipatory unfolded protein response and regulates cancer cell fate under stress. Biochim Biophys Acta Mol Cell Res. 2020;:118765 pubmed publisher |
Akdag M, Yunt Z, Kamacıoğlu A, Qureshi M, Akarlar B, Ozlu N. Proximal Biotinylation-Based Combinatory Approach for Isolating Integral Plasma Membrane Proteins. J Proteome Res. 2020;: pubmed publisher |
Bruggisser J, Tarek B, Wyder M, Müller P, von Ballmoos C, Witz G, et al. CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. Cell Host Microbe. 2020;28:69-78.e6 pubmed publisher |
Hino N, Rossetti L, Marín Llauradó A, Aoki K, Trepat X, Matsuda M, et al. ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization. Dev Cell. 2020;53:646-660.e8 pubmed publisher |
Li H, Bi Y, Li Y, Fu R, Lv W, Jiang N, et al. A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer. Sci Adv. 2020;6:eaaw8500 pubmed publisher |
Bo Y, Qiu S, Mulloy R, Côté M. Filoviruses use the HOPS complex and UVRAG to traffic to Niemann-Pick C1 compartments during viral entry. J Virol. 2020;: pubmed publisher |
Ibrahim M, Lu C, Klement J, Redd P, Yang D, Smith A, et al. Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells. Cancer Immunol Immunother. 2020;: pubmed publisher |
Chen S, Hsieh Y, Tzeng H, Lin C, Hsu K, Chiang Y, et al. ABL Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo. Cancers (Basel). 2020;12: pubmed publisher |
Pinch B, Doctor Z, Nabet B, Browne C, Seo H, Mohardt M, et al. Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 2020;: pubmed publisher |
Sakata R, Ishiguro S, Mori H, Tanaka M, Tatsuno K, Ueda H, et al. Base editors for simultaneous introduction of C-to-T and A-to-G mutations. Nat Biotechnol. 2020;38:865-869 pubmed publisher |
Schraivogel D, Gschwind A, Milbank J, Leonce D, Jakob P, Mathur L, et al. Targeted Perturb-seq enables genome-scale genetic screens in single cells. Nat Methods. 2020;17:629-635 pubmed publisher |
Wang S, Liu J, Qin J, Zhu Y, Tin V, Yam J, et al. CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation. Cell Death Dis. 2020;11:410 pubmed publisher |
Lin H, Robertson K, Lellupitiyage Don S, Taylor S, Farkas M. Chemical modulation of circadian rhythms and assessment of cellular behavior via indirubin and derivatives. Methods Enzymol. 2020;639:115-140 pubmed publisher |
Sha C, Jia G, Jingjing Z, Yapeng H, Zhi L, Guanghui X. miR-486 is involved in the pathogenesis of acute myeloid leukemia by regulating JAK-STAT signaling. Naunyn Schmiedebergs Arch Pharmacol. 2020;: pubmed publisher |
Wang X, Qiao X, Sui L, Zhao H, Li F, Tang Y, et al. Establishment of stable Vero cell lines expressing TMPRSS2 and MSPL: A useful tool for propagating porcine epidemic diarrhea virus in the absence of exogenous trypsin. Virulence. 2020;11:669-685 pubmed publisher |
Ding C, Rose J, Sun T, Wu J, Chen P, Lin C, et al. MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Nat Metab. 2020;2:270-277 pubmed publisher |
Korotkov A, Puhakka N, Gupta S, Vuokila N, Broekaart D, Anink J, et al. Increased expression of miR142 and miR155 in glial and immune cells after traumatic brain injury may contribute to neuroinflammation via astrocyte activation. Brain Pathol. 2020;: pubmed publisher |
Velazco Cruz L, Goedegebuure M, Maxwell K, Augsornworawat P, Hogrebe N, Millman J. SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Cell Rep. 2020;31:107687 pubmed publisher |
Chuang Y, Lee C, Lin C, Liu C, Huang S, Lee J, et al. An Integrated Genomic Strategy to Identify CHRNB4 as a Diagnostic/Prognostic Biomarker for Targeted Therapy in Head and Neck Cancer. Cancers (Basel). 2020;12: pubmed publisher |
Beker M, Cağlayan A, Beker M, Altunay S, Karacay R, Dalay A, et al. Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins. Exp Neurol. 2020;331:113364 pubmed publisher |
Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty J, et al. DNA damage invokes mitophagy through a pathway involving Spata18. Nucleic Acids Res. 2020;48:6611-6623 pubmed publisher |
Cao W, Fang F, Gould T, Li X, Kim C, Gustafson C, et al. Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. J Clin Invest. 2020;130:3422-3436 pubmed publisher |
Das A, Barrientos R, Shiota T, Madigan V, Misumi I, McKnight K, et al. Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus. Nat Microbiol. 2020;: pubmed publisher |
Kadota S, Ou J, Shi Y, Lee J, Sun J, Yildirim E. Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Nat Commun. 2020;11:2606 pubmed publisher |
Pflügler S, Svinka J, Scharf I, Crncec I, Filipits M, Charoentong P, et al. IDO1+ Paneth cells promote immune escape of colorectal cancer. Commun Biol. 2020;3:252 pubmed publisher |
You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, et al. Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. Virulence. 2020;11:537-553 pubmed publisher |
Stöhr D, Schmid J, Beigl T, Mack A, Maichl D, Cao K, et al. Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death Differ. 2020;: pubmed publisher |
Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, et al. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Res. 2020;48:6001-6018 pubmed publisher |
Moutin E, Hemonnot A, Seube V, Linck N, Rassendren F, Perroy J, et al. Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons. Front Synaptic Neurosci. 2020;12:19 pubmed publisher |
Oishi N, Hundal T, Phillips J, Dasari S, Hu G, Viswanatha D, et al. Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. Haematologica. 2020;: pubmed publisher |
Bikbaev A, Ciuraszkiewicz Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, et al. Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development. J Neurosci. 2020;40:4824-4841 pubmed publisher |
Xu H, Pumiglia K, LaFlamme S. Laminin-511 and α6 integrins regulate the expression of CXCR4 to promote endothelial morphogenesis. J Cell Sci. 2020;133: pubmed publisher |
Kim G, Aragon Sanabria V, Randolph L, Jiang H, Reynolds J, Webb B, et al. High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma. Bioact Mater. 2020;5:624-635 pubmed publisher |
Sanghani H, Jagannath A, Humberstone T, Ebrahimjee F, Thomas J, Churchill G, et al. Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder. Mol Psychiatry. 2020;: pubmed publisher |
Williams G, Gokhale N, Snider D, Horner S. The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. mSphere. 2020;5: pubmed publisher |
Chen C, Strouz K, Huang K, Shyu A. Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation. RNA. 2020;: pubmed publisher |
Adam R, Yang H, Ge Y, Infarinato N, Gur Cohen S, Miao Y, et al. NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Nat Cell Biol. 2020;22:640-650 pubmed publisher |
Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, et al. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020;12:e11571 pubmed publisher |
Bensimon A, Pizzagalli M, Kartnig F, Dvorak V, Essletzbichler P, Winter G, et al. Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis. Cell Chem Biol. 2020;27:728-739.e9 pubmed publisher |
Jaiswal P, Aljebali L, Gaumond M, Oh C, Yasuda H, Moffatt P. Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Sci Rep. 2020;10:7790 pubmed publisher |
Sürün D, Schneider A, Mircetic J, Neumann K, Lansing F, Paszkowski Rogacz M, et al. Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors. Genes (Basel). 2020;11: pubmed publisher |
Han C, Du Q, Zhu L, Chen N, Luo L, Chen Q, et al. Porcine DNAJB6 promotes PCV2 replication via enhancing the formation of autophagy in host cells. Vet Res. 2020;51:61 pubmed publisher |
Yamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed publisher |
Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, et al. An Alternative Splicing of Tupaia STING Modulated Anti-RNA Virus Responses by Targeting MDA5-LGP2 and IRF3. J Immunol. 2020;204:3191-3204 pubmed publisher |
Bare D, Cherny V, DeCoursey T, Abukhdeir A, Morgan D. Expression and function of voltage gated proton channels (Hv1) in MDA-MB-231 cells. PLoS ONE. 2020;15:e0227522 pubmed publisher |
Gobillot T, Humes D, Sharma A, Kikawa C, Overbaugh J. The Robust Restriction of Zika Virus by Type-I Interferon in A549 Cells Varies by Viral Lineage and Is Not Determined by IFITM3. Viruses. 2020;12: pubmed publisher |
Oizel K, Tait Mulder J, Fernandez de Cossio Diaz J, Pietzke M, Brunton H, Lilla S, et al. Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death Dis. 2020;11:310 pubmed publisher |
Deng M, Tam J, Wang L, Liang K, Li S, Zhang L, et al. TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination. Nat Commun. 2020;11:2193 pubmed publisher |
Adjibade P, Simoneau B, Ledoux N, Gauthier W, Nkurunziza M, Khandjian E, et al. Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation. PLoS ONE. 2020;15:e0231894 pubmed publisher |
Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M. FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity. 2020;52:978-993.e6 pubmed publisher |
Faergeman S, Evans H, Attfield K, Desel C, Kuttikkatte S, Sommerlund M, et al. A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. Cell Death Dis. 2020;11:303 pubmed publisher |
Zhang Y, Chen X, Li J, He F, Li X, Guo Y. lncRNA Neat1 Stimulates Osteoclastogenesis Via Sponging miR-7. J Bone Miner Res. 2020;: pubmed publisher |
Lucken Ardjomande Häsler S, Vallis Y, Pasche M, McMahon H. GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508. J Cell Biol. 2020;219: pubmed publisher |
Chen H, Gao L, Yuan J, Zhang Y, Liu P, Wang G, et al. Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor. Am J Physiol Endocrinol Metab. 2020;318:E930-E942 pubmed publisher |
Trembinski D, Bink D, Theodorou K, Sommer J, Fischer A, van Bergen A, et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun. 2020;11:2039 pubmed publisher |
Parker S, Amendola C, Hollinshead K, Yu Q, Yamamoto K, Encarnación Rosado J, et al. Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer. Cancer Discov. 2020;10:1018-1037 pubmed publisher |
Corona R, Seo J, Lin X, Hazelett D, Reddy J, Fonseca M, et al. Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer. Nat Commun. 2020;11:2020 pubmed publisher |
He Y, Zhang X, Chang J, Kim H, Zhang P, Wang Y, et al. Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. Nat Commun. 2020;11:1996 pubmed publisher |
Gillespie M, Palii C, Sánchez Taltavull D, Shannon P, Longabaugh W, Downes D, et al. Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis. Mol Cell. 2020;78:960-974.e11 pubmed publisher |
Kwon J, Vankara A, Ettyreddy A, Bohning J, Gersbach C. Myogenic Progenitor Cell Lineage Specification by CRISPR/Cas9-Based Transcriptional Activators. Stem Cell Reports. 2020;14:755-769 pubmed publisher |
Mann S, Zhou Z, Landry L, Anderson A, Alkanani A, Fischer J, et al. Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System. Front Immunol. 2020;11:633 pubmed publisher |
Kretschmer M, Kadlubowska P, Hoffmann D, Schwalbe B, Auerswald H, Schreiber M. Zikavirus prME Envelope Pseudotyped Human Immunodeficiency Virus Type-1 as a Novel Tool for Glioblastoma-Directed Virotherapy. Cancers (Basel). 2020;12: pubmed publisher |
Ashja Arvan M, Dehbashi M, Eslami A, Salehi H, Yoosefi M, Ganjalikhani Hakemi M. Impact of IFN-β and LIF overexpression on human adipose-derived stem cells properties. J Cell Physiol. 2020;: pubmed publisher |
Morita K, He S, Nowak R, Wang J, Zimmerman M, Fu C, et al. Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Cell. 2020;181:702-715.e20 pubmed publisher |
Melick C, Meng D, Jewell J. A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth. J Biol Chem. 2020;295:8096-8105 pubmed publisher |
Gao Q, Ouyang W, Kang B, Han X, Xiong Y, Ding R, et al. Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression. Theranostics. 2020;10:5137-5153 pubmed publisher |
Srivastava M, Su D, Zhang H, Chen Z, Tang M, Nie L, et al. HMCES safeguards replication from oxidative stress and ensures error-free repair. EMBO Rep. 2020;21:e49123 pubmed publisher |
Gunne Braden A, Sullivan A, Gharibi B, Sheriff R, Maity A, Wang Y, et al. GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells. Cell Stem Cell. 2020;26:693-706.e9 pubmed publisher |
Zheng M, Karki R, Vogel P, Kanneganti T. Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell. 2020;181:674-687.e13 pubmed publisher |
Stojic L, Lun A, Mascalchi P, Ernst C, Redmond A, Mangei J, et al. A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun. 2020;11:1851 pubmed publisher |
Luedtke D, Su Y, Ma J, Li X, Buck S, Edwards H, et al. Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia. Signal Transduct Target Ther. 2020;5:17 pubmed publisher |
Dinh T, Sritharan R, Smith F, Francisco A, Ma R, Bunaciu R, et al. Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities. Cell Rep. 2020;31:107509 pubmed publisher |
Tai Schmiedel J, Karniely S, Lau B, Ezra A, Eliyahu E, Nachshon A, et al. Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication. PLoS Pathog. 2020;16:e1008390 pubmed publisher |
Wright G, Huang D, Phelan J, Coulibaly Z, Roulland S, Young R, et al. A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Cancer Cell. 2020;37:551-568.e14 pubmed publisher |
Jiang S, Zhou F, Zhang Y, Zhou W, Zhu L, Zhang M, et al. Identification of tumorigenicity-associated genes in osteosarcoma cell lines based on bioinformatic analysis and experimental validation. J Cancer. 2020;11:3623-3633 pubmed publisher |
Park D, Cheng J, McGrath J, Lim M, Cushman C, Swanson S, et al. Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Nat Cell Biol. 2020;22:603-615 pubmed publisher |
Rashid A, Wang R, Zhang L, Yue J, Yang M, Yen A. Dissecting the novel partners of nuclear c-Raf and its role in all-trans retinoic acid (ATRA)-induced myeloblastic leukemia cells differentiation. Exp Cell Res. 2020;:111989 pubmed publisher |
OhAinle M, Kim K, Komurlu Keceli S, Felton A, Campbell E, Luban J, et al. TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner. PLoS Pathog. 2020;16:e1008507 pubmed publisher |
Xiao Y, Lamar J. Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter. J Vis Exp. 2020;: pubmed publisher |
Przanowska R, Sobierajska E, Su Z, Jensen K, Przanowski P, Nagdas S, et al. miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis in vitro. FASEB J. 2020;34:7687-7702 pubmed publisher |
Orge I, Gadd V, Barouh J, Rossi E, Carvalho R, Smith I, et al. Phenotype instability of hepatocyte-like cells produced by direct reprogramming of mesenchymal stromal cells. Stem Cell Res Ther. 2020;11:154 pubmed publisher |
Zheng L, Ren L, Kouhi A, Khawli L, Hu P, Kaslow H, et al. A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models. Clin Cancer Res. 2020;26:3694-3706 pubmed publisher |
Murugaiah V, Varghese P, Saleh S, Tsolaki A, Alrokayan S, Khan H, et al. Complement-Independent Modulation of Influenza A Virus Infection by Factor H. Front Immunol. 2020;11:355 pubmed publisher |
Sharma S, Munger K. KDM6A-Mediated Expression of the Long Noncoding RNA DINO Causes TP53 Tumor Suppressor Stabilization in Human Papillomavirus 16 E7-Expressing Cells. J Virol. 2020;94: pubmed publisher |
Lambert J, Makin K, Akbareian S, Johnson R, Alghamdi A, Robinson S, et al. ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis. J Cell Sci. 2020;133: pubmed publisher |
Kato S, Weng Q, Insco M, Chen K, Muralidhar S, Poźniak J, et al. Gain-of-Function Genetic Alterations of G9a Drive Oncogenesis. Cancer Discov. 2020;10:980-997 pubmed publisher |
Ali A, Stenglein M, Spencer T, Bouma G, Anthony R, Winger Q. Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus. Int J Mol Sci. 2020;21: pubmed publisher |
Drainas A, Lambuta R, Ivanova I, Serçin O, Sarropoulos I, Smith M, et al. Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells. Cell Rep. 2020;31:107465 pubmed publisher |
Zhou X, Li R, Jing R, Zuo B, Zheng Q. Genome-wide CRISPR knockout screens identify ADAMTSL3 and PTEN genes as suppressors of HCC proliferation and metastasis, respectively. J Cancer Res Clin Oncol. 2020;146:1509-1521 pubmed publisher |
Mukherjee S, Darzi S, Paul K, Cousins F, Werkmeister J, Gargett C. Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor. Front Pharmacol. 2020;11:353 pubmed publisher |
Tajima K, Ikeda K, Tanabe Y, Thomson E, Yoneshiro T, Oguri Y, et al. Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. Nat Commun. 2020;11:1730 pubmed publisher |
Hii L, Chung F, Mai C, Yee Z, Chan H, Raja V, et al. Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1. Cells. 2020;9: pubmed publisher |
Rashid A, Duan X, Gao F, Yang M, Yen A. Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment of an ensemble of activated signaling molecules and augments ATRA-induced myeloid cell differentiation. Oncotarget. 2020;11:1017-1036 pubmed publisher |
Yamauchi T, Hoki T, Oba T, Saito H, Attwood K, Sabel M, et al. CX3CR1-CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. JCI Insight. 2020;5: pubmed publisher |
Haumann S, Boix J, Knuever J, Bieling A, Vila Sanjurjo A, Elson J, et al. Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells. Carcinogenesis. 2020;: pubmed publisher |
Smeester B, Slipek N, Pomeroy E, Laoharawee K, Osum S, Larsson A, et al. PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma. Bone. 2020;136:115353 pubmed publisher |
Madhu V, Boneski P, Silagi E, Qiu Y, Kurland I, Guntur A, et al. Hypoxic Regulation of Mitochondrial Metabolism and Mitophagy in Nucleus Pulposus Cells Is Dependent on HIF-1α-BNIP3 Axis. J Bone Miner Res. 2020;: pubmed publisher |
Sassi A, Wang Y, Chassot A, Komarynets O, Roth I, Olivier V, et al. Interaction between Epithelial Sodium Channel γ-Subunit and Claudin-8 Modulates Paracellular Sodium Permeability in Renal Collecting Duct. J Am Soc Nephrol. 2020;31:1009-1023 pubmed publisher |
Wang Y, Li H, Li Y, Zhang S, Jin Y. (20S)G-Rh2 Inhibits NF-κB Regulated Epithelial-Mesenchymal Transition by Targeting Annexin A2. Biomolecules. 2020;10: pubmed publisher |
Jun S, Lim H, Chun H, Lee J, Bang D. Single-cell analysis of a mutant library generated using CRISPR-guided deaminase in human melanoma cells. Commun Biol. 2020;3:154 pubmed publisher |
Minor M, Hollinger F, McNees A, Jung S, Jain A, Hyser J, et al. Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex. Cells. 2020;9: pubmed publisher |
Santoriello C, Sporrij A, Yang S, Flynn R, Henriques T, Dorjsuren B, et al. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells. Nat Cell Biol. 2020;22:372-379 pubmed publisher |
Hwang I, Pan H, Yao J, Elemento O, Zheng H, Paik J. CIC is a critical regulator of neuronal differentiation. JCI Insight. 2020;5: pubmed publisher |
Blaževitš O, Bolshette N, Vecchio D, Guijarro A, Croci O, Campaner S, et al. MYC-Associated Factor MAX is a Regulator of the Circadian Clock. Int J Mol Sci. 2020;21: pubmed publisher |
Liu Y, Lu Y, Li A, Celiku O, Han S, Qian M, et al. mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma. Cancers (Basel). 2020;12: pubmed publisher |
Huang L, Liu Z, Hu J, Luo Z, Zhang C, Wang L, et al. MiR-377-3p suppresses colorectal cancer through negative regulation on Wnt/β-catenin signaling by targeting XIAP and ZEB2. Pharmacol Res. 2020;156:104774 pubmed publisher |
Jühling F, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, et al. Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma. Gut. 2020;: pubmed publisher |
Viol L, Hata S, Pastor Peidro A, Neuner A, Murke F, Wuchter P, et al. Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020;219: pubmed publisher |
Rathore A, Iketani S, Wang P, Jia M, Sahi V, Ho D. CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models. Sci Rep. 2020;10:5350 pubmed publisher |
Wang J, Li G, Ming S, Wang C, Shi L, Su B, et al. BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses. PLoS Pathog. 2020;16:e1008429 pubmed publisher |
Ikegami K, Secchia S, Almakki O, Lieb J, Moskowitz I. Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria. Dev Cell. 2020;52:699-713.e11 pubmed publisher |
Álvarez Salamero C, Castillo González R, Pastor Fernández G, Mariblanca I, Pino J, Cibrian D, et al. IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics. PLoS Biol. 2020;18:e3000646 pubmed publisher |
Huynh N, Gloss C, Lorentz J, Tang R, Brunger J, McAlinden A, et al. Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway. elife. 2020;9: pubmed publisher |
Tang L, Yang M, Qin L, Li X, He G, Liu X, et al. Deficiency of DICER reduces the invasion ability of trophoblasts and impairs the pro-angiogenic effect of trophoblast-derived microvesicles. J Cell Mol Med. 2020;24:4915-4930 pubmed publisher |
Li Y, Wu S, Yu Y, Zhang H, Wei R, Lv J, et al. Derivation of porcine extraembryonic endoderm-like cells from blastocysts. Cell Prolif. 2020;53:e12782 pubmed publisher |
Biehler C, Wang L, Sévigny M, Jetté A, Gamblin C, Catterall R, et al. Girdin is a component of the lateral polarity protein network restricting cell dissemination. PLoS Genet. 2020;16:e1008674 pubmed publisher |
Yu L, Wang L, Yi H, Wu X. LRP6-CRISPR prevents activation of hepatic stellate cells and liver fibrogenesis in rats. Am J Transl Res. 2020;12:397-408 pubmed |
Zhou B, Chen T, Jiang Y, Wei X, Lu C, Li J, et al. Scinderin suppresses cell proliferation and predicts the poor prognosis of hepatocellular carcinoma. Oncol Lett. 2020;19:2011-2020 pubmed publisher |
Ye L, Zhang J, Zhang Y, Gu B, Zhu H, Mao X. Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. Biomed Res Int. 2020;2020:9259852 pubmed publisher |
Vasmehjani A, Salehi Vaziri M, Azadmanesh K, Nejati A, Pouriayevali M, Gouya M, et al. Efficient production of a lentiviral system for displaying Crimean-Congo hemorrhagic fever virus glycoproteins reveals a broad range of cellular susceptibility and neutralization ability. Arch Virol. 2020;165:1109-1120 pubmed publisher |
Oostdyk L, Wang Z, Zang C, Li H, McConnell M, Paschal B. An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding. Sci Rep. 2020;10:4844 pubmed publisher |
Kanasugi J, Hanamura I, Ota A, Karnan S, Lam V, Mizuno S, et al. Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Cancer Sci. 2020;111:1663-1675 pubmed publisher |
Ghaddar N, Wang S, Michaud V, Kazimierczak U, Ah Son N, Koromilas A. Detection of Lung Tumor Progression in Mice by Ultrasound Imaging. J Vis Exp. 2020;: pubmed publisher |
Kim J, Adams A, Gokina P, Zambrano B, Jayakumaran J, Dobrowolski R, et al. Mechanical stretch induces myelin protein loss in oligodendrocytes by activating Erk1/2 in a calcium-dependent manner. Glia. 2020;: pubmed publisher |
Dietz A, Dalda N, Zielke S, Dittmann J, van Wijk S, Vogler M, et al. Proteasome inhibitors and Smac mimetics cooperate to induce cell death in diffuse large B-cell lymphoma by stabilizing NOXA and triggering mitochondrial apoptosis. Int J Cancer. 2020;147:1485-1498 pubmed publisher |
Wan T, Chen Y, Pan Q, Xu X, Kang Y, Gao X, et al. Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy. J Control Release. 2020;322:236-247 pubmed publisher |
Yoneda R, Ueda N, Uranishi K, Hirasaki M, Kurokawa R. Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m6A modification. J Biol Chem. 2020;295:5626-5639 pubmed publisher |
Bergerhausen L, Grosche J, Meißner J, Hecker C, Caliandro M, Westerhausen C, et al. Extracellular Redox Regulation of α7β Integrin-Mediated Cell Migration Is Signaled via a Dominant Thiol-Switch. Antioxidants (Basel). 2020;9: pubmed publisher |
Tsuboyama K, Osaki T, Matsuura Suzuki E, Kozuka Hata H, Okada Y, Oyama M, et al. A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PLoS Biol. 2020;18:e3000632 pubmed publisher |
Ivanova A, Kravchenko D, Chumakov S. [A Modified Lentivirus-Based Reporter for Magnetic Separation of Cancer Stem Cells]. Mol Biol (Mosk). 2020;54:95-102 pubmed publisher |
Dennis J, Splawn T, Kean T. High-Throughput, Temporal and Dose Dependent, Effect of Vitamins and Minerals on Chondrogenesis. Front Cell Dev Biol. 2020;8:92 pubmed publisher |
He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, et al. PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat. J Virol. 2020;94: pubmed publisher |
Ólafsson E, Ten Hoeve A, Li Wang X, Westermark L, Varas Godoy M, Barragan A. Convergent Met and voltage-gated Ca2+ channel signaling drives hypermigration of Toxoplasma-infected dendritic cells. J Cell Sci. 2020;134: pubmed publisher |
Liao W, Hsu C, Chan T, Yen C, Chen W, Pan H, et al. Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Stem Cell Reports. 2020;14:462-477 pubmed publisher |
Ma H, Qian W, Bambousková M, Collins P, Porter S, Byrum A, et al. Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. MBio. 2020;11: pubmed publisher |
Watters K, Shivram H, Fellmann C, Lew R, McMahon B, Doudna J. Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes. Proc Natl Acad Sci U S A. 2020;117:6531-6539 pubmed publisher |
Canonne M, Wanet A, Nguyen T, Khelfi A, Ayama Canden S, Van Steenbrugge M, et al. MPV17 does not control cancer cell proliferation. PLoS ONE. 2020;15:e0229834 pubmed publisher |
Place D, Briard B, Samir P, Karki R, Bhattacharya A, Guy C, et al. Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion. PLoS Pathog. 2020;16:e1008364 pubmed publisher |
Ray J, de Boer C, Fulco C, Lareau C, Kanai M, Ulirsch J, et al. Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features. Nat Commun. 2020;11:1237 pubmed publisher |
Kulcsár P, Tálas A, Tóth E, Nyeste A, Ligeti Z, Welker Z, et al. Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5'G-extended sgRNAs. Nat Commun. 2020;11:1223 pubmed publisher |
Stubb A, Laine R, Miihkinen M, Hamidi H, Guzman C, Henriques R, et al. Fluctuation-Based Super-Resolution Traction Force Microscopy. Nano Lett. 2020;20:2230-2245 pubmed publisher |
Klein S, Mentrup B, Timmen M, Sherwood J, Lindemann O, Fobker M, et al. Modulation of Transient Receptor Potential Channels 3 and 6 Regulates Osteoclast Function with Impact on Trabecular Bone Loss. Calcif Tissue Int. 2020;106:655-664 pubmed publisher |
Chan A, Huber A, Lamia K. Cryptochromes modulate E2F family transcription factors. Sci Rep. 2020;10:4077 pubmed publisher |
Białopiotrowicz E, Noyszewska Kania M, Kachamakova Trojanowska N, Łoboda A, Cybulska M, Grochowska A, et al. Serine Biosynthesis Pathway Supports MYC-miR-494-EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells. Cancers (Basel). 2020;12: pubmed publisher |
Zhang M, Du W, Acklin S, Jin S, Xia F. SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. J Clin Invest. 2020;130:2953-2965 pubmed publisher |
Catizone A, Uzunbas G, Celadova P, Kuang S, Bose D, Sammons M. Locally acting transcription factors regulate p53-dependent cis-regulatory element activity. Nucleic Acids Res. 2020;48:4195-4213 pubmed publisher |
Mazhar S, Leonard D, Sosa A, Schlatzer D, Thomas D, Narla G. Challenges and Reinterpretation of Antibody-Based Research on Phosphorylation of Tyr307 on PP2Ac. Cell Rep. 2020;30:3164-3170.e3 pubmed publisher |
Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels H, et al. High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation. Cell Rep. 2020;30:2859-2868.e5 pubmed publisher |
Shats I, Williams J, Liu J, Makarov M, Wu X, Lih F, et al. Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. Cell Metab. 2020;31:564-579.e7 pubmed publisher |
Santana Magal N, Farhat Younis L, Gutwillig A, Gleiberman A, Rasoulouniriana D, Tal L, et al. Melanoma-Secreted Lysosomes Trigger Monocyte-Derived Dendritic Cell Apoptosis and Limit Cancer Immunotherapy. Cancer Res. 2020;80:1942-1956 pubmed publisher |
Muller L, Rietscher K, Keil R, Neuholz M, Hatzfeld M. Plakophilin 3 phosphorylation by ribosomal S6 kinases supports desmosome assembly. J Cell Sci. 2020;133: pubmed publisher |
Imkeller K, Ambrosi G, Boutros M, Huber W. gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection. Genome Biol. 2020;21:53 pubmed publisher |
Pascoal S, Salzer B, Scheuringer E, Wenninger Weinzierl A, Sturtzel C, Holter W, et al. A Preclinical Embryonic Zebrafish Xenograft Model to Investigate CAR T Cells In Vivo. Cancers (Basel). 2020;12: pubmed publisher |
Murphy Schafer A, Smith J, Pryke K, DeFilippis V, Hirsch A. The E3 Ubiquitin Ligase SIAH1 Targets MyD88 for Proteasomal Degradation During Dengue Virus Infection. Front Microbiol. 2020;11:24 pubmed publisher |
Kim B, Sun R, Oh W, Kim A, Schwarz J, Lim S. Saccharide analog, 2-deoxy-d-glucose enhances 4-1BB-mediated antitumor immunity via PD-L1 deglycosylation. Mol Carcinog. 2020;59:691-700 pubmed publisher |
He X, Yan L, Wu Q, Zhang G, Zhou N. Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and β-arrestin2/BmKurtz. Biochim Biophys Acta Mol Cell Res. 2020;1867:118690 pubmed publisher |
de Jong O, Murphy D, Mäger I, Willms E, Garcia Guerra A, Gitz Francois J, et al. A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. Nat Commun. 2020;11:1113 pubmed publisher |
Kyriakou K, Lederer C, Kleanthous M, Drousiotou A, Malekkou A. Acid Ceramidase Depletion Impairs Neuronal Survival and Induces Morphological Defects in Neurites Associated with Altered Gene Transcription and Sphingolipid Content. Int J Mol Sci. 2020;21: pubmed publisher |
Nachtigal A, Milenkovic A, Brandl C, Schulz H, Duerr L, Lang G, et al. Mutation-Dependent Pathomechanisms Determine the Phenotype in the Bestrophinopathies. Int J Mol Sci. 2020;21: pubmed publisher |
Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, et al. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020;180:984-1001.e22 pubmed publisher |
Zhou L, Wang D, Sheng D, Xu J, Chen W, Qin Y, et al. NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer. Theranostics. 2020;10:2405-2421 pubmed publisher |
Zhang J, Yu W, Wang X, Hu B, Wu D, Shi G. KLF16 Affects the MYC Signature and Tumor Growth in Prostate Cancer. Onco Targets Ther. 2020;13:1303-1310 pubmed publisher |
Qiu Z, Lin A, Jiang S, Elkashef S, Myers J, Srikantan S, et al. MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Cell Chem Biol. 2020;27:538-550.e7 pubmed publisher |
Roldán J, Cassola A, Castillo D. Optimization of recombinant Zika virus NS1 protein secretion from HEK293 cells. Biotechnol Rep (Amst). 2020;25:e00434 pubmed publisher |
Mock J, Pellegrino C, Neri D. A universal reporter cell line for bioactivity evaluation of engineered cytokine products. Sci Rep. 2020;10:3234 pubmed publisher |
Saleh T, Tyutyunyk Massey L, Patel N, Cudjoe E, Alotaibi M, Gewirtz D. Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy. Int J Mol Sci. 2020;21: pubmed publisher |
Teraoka S, Muguruma M, Takano N, Miyahara K, Kawate T, Kaise H, et al. Association of BRCA Mutations and BRCAness Status With Anticancer Drug Sensitivities in Triple-Negative Breast Cancer Cell Lines. J Surg Res. 2020;250:200-208 pubmed publisher |
Wang J, Jiang X, Zhao L, Zuo S, Chen X, Zhang L, et al. Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators. Acta Pharm Sin B. 2020;10:313-326 pubmed publisher |
Lee A, Pan D, Bao X, Hu M, Li F, Li C. Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. Radiat Res. 2020;193:305-317 pubmed publisher |
Farrants H, Tarnawski M, Müller T, Otsuka S, Hiblot J, Koch B, et al. Chemogenetic Control of Nanobodies. Nat Methods. 2020;17:279-282 pubmed publisher |
He Y, Li W, Lv D, Zhang X, Zhang X, Ortiz Y, et al. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging Cell. 2020;19:e13117 pubmed publisher |
Shao M, Wang D, Zhou Y, Du K, Liu W. Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis. Int Immunopharmacol. 2020;81:106212 pubmed publisher |
Romero Masters J, Huebner S, Ohashi M, Bristol J, Benner B, Barlow E, et al. B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection. PLoS Pathog. 2020;16:e1008365 pubmed publisher |
Zhu M, Du L, Zhao R, Wang H, Zhao Y, Nie G, et al. Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation. ACS Nano. 2020;14:3703-3717 pubmed publisher |
Park J, Burckhardt C, Lazcano R, Solis L, Isogai T, Li L, et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. 2020;578:621-626 pubmed publisher |
Akiyama H, Umezawa Y, Watanabe D, Okada K, Ishida S, Nogami A, et al. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Cancers (Basel). 2020;12: pubmed publisher |
Lee S, Krieger J, Vergara M, Quinn D, McDougle M, de Araujo A, et al. Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. Cell Rep. 2020;30:2028-2039.e4 pubmed publisher |
Mita P, Sun X, Fenyo D, Kahler D, Li D, Agmon N, et al. BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Nat Struct Mol Biol. 2020;27:179-191 pubmed publisher |
Rashid A, Duan X, Gao F, Yang M, Yen A. Roscovitine enhances All-trans retinoic acid (ATRA)-induced leukemia cell differentiation: Novel effects on signaling molecules for a putative Cdk2 inhibitor. Cell Signal. 2020;71:109555 pubmed publisher |
Wang H, Zhang S, Song L, Qu M, Zou Z. Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Oncogene. 2020;39:2905-2920 pubmed publisher |
DeWeirdt P, Sangree A, Hanna R, Sanson K, Hegde M, Strand C, et al. Genetic screens in isogenic mammalian cell lines without single cell cloning. Nat Commun. 2020;11:752 pubmed publisher |
Lau M, Ghazanfar S, Parkin A, Chou A, Rouaen J, Littleboy J, et al. Systematic functional identification of cancer multi-drug resistance genes. Genome Biol. 2020;21:27 pubmed publisher |
Fiedorowicz K, Rozwadowska N, Zimna A, Malcher A, Tutak K, Szczerbal I, et al. Tissue-specific promoter-based reporter system for monitoring cell differentiation from iPSCs to cardiomyocytes. Sci Rep. 2020;10:1895 pubmed publisher |
Yu L, Kim J, Jiang L, Feng B, Ying Y, Ji K, et al. MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. Nat Commun. 2020;11:708 pubmed publisher |
Javidi Parsijani P, Lyu P, Makani V, Sarhan W, Yoo K, El Korashi L, et al. CRISPR/Cas9 increases mitotic gene conversion in human cells. Gene Ther. 2020;27:281-296 pubmed publisher |
Hale A, Brown R, Luka Z, Hudson B, Matta P, Williams C, et al. Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Adv Biol Regul. 2020;76:100694 pubmed publisher |
Yang J, Meng C, Weisberg E, Case A, Lamberto I, Magin R, et al. Inhibition of the deubiquitinase USP10 induces degradation of SYK. Br J Cancer. 2020;122:1175-1184 pubmed publisher |
Yang Y, Wei Q, Tang Y, Yuanyuan Wang -, Luo Q, Zhao H, et al. Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer Lett. 2020;475:43-52 pubmed publisher |
Su V, Simon B, Draheim K, Calderwood D. Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation. J Biol Chem. 2020;295:3269-3284 pubmed publisher |
Oladimeji P, Bakke J, Wright W, Chen T. KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. Sci Rep. 2020;10:1485 pubmed publisher |
Williams J, Li S, Higgs E, Cabanov A, Wang X, Huang H, et al. Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells. Nat Commun. 2020;11:602 pubmed publisher |
Wei M, Haney M, Rivas D, Blackburn J. Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) drives migration and progression of T-cell acute lymphoblastic leukemia in vitro and in vivo. Oncogenesis. 2020;9:6 pubmed publisher |
Li C, Li J, He F, Li K, Li X, Zhang Y. Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity. Adipocyte. 2020;9:68-76 pubmed publisher |
Rosales Gerpe M, van Lieshout L, Domm J, van Vloten J, Datu J, Ingrao J, et al. Optimized Pre-Clinical Grade Production of Two Novel Lentiviral Vector Pseudotypes for Lung Gene Delivery. Hum Gene Ther. 2020;31:459-471 pubmed publisher |
Liu T, Wei Q, Jin J, Luo Q, Liu Y, Yang Y, et al. The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation. Nucleic Acids Res. 2020;48:3816-3831 pubmed publisher |
Bryan A, Wang J, Howard G, Guarnaccia A, Woodley C, Aho E, et al. WDR5 is a conserved regulator of protein synthesis gene expression. Nucleic Acids Res. 2020;48:2924-2941 pubmed publisher |
Qadir A, Stults A, Murmann A, Peter M. The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer. Sci Rep. 2020;10:1310 pubmed publisher |
Dunn P, Salm E, Tomita S. ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity. J Biol Chem. 2020;295:5192-5203 pubmed publisher |
Panda S, Wigerblad G, Jiang L, Jiménez Andrade Y, Iyer V, Shen Y, et al. IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints. Proc Natl Acad Sci U S A. 2020;117:3103-3113 pubmed publisher |
Yang L, Zhu Y, Yu H, Cheng X, Chen S, Chu Y, et al. scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Genome Biol. 2020;21:19 pubmed publisher |
Grotz A, Abaitua F, Navarro Guerrero E, Hastoy B, Ebner D, Gloyn A. A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function. Wellcome Open Res. 2019;4:150 pubmed publisher |
Hsu W, Ma Y, Liu Y, Tai D, Lee E. Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome. Sci Rep. 2020;10:1074 pubmed publisher |
Zhou S, Hawley J, Soares F, Grillo G, Teng M, Madani Tonekaboni S, et al. Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Nat Commun. 2020;11:441 pubmed publisher |
Madigan J, Robey R, Poprawski J, Huang H, Clarke C, Gottesman M, et al. A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer. Exp Cell Res. 2020;388:111860 pubmed publisher |
Hiranniramol K, Chen Y, Liu W, Wang X. Generalizable sgRNA design for improved CRISPR/Cas9 editing efficiency. Bioinformatics. 2020;36:2684-2689 pubmed publisher |
Johnson J, De Veaux N, Rives A, Lahaye X, Lucas S, Perot B, et al. A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV. Cell Rep. 2020;30:914-931.e9 pubmed publisher |
Xie H, Gu Y, Wang W, Wang X, Ye X, Xin C, et al. Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation. Sci Rep. 2020;10:766 pubmed publisher |
Showalter A, Martini A, Nierenberg D, Hosang K, Fahmi N, Gopalan P, et al. Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis. Sci Rep. 2020;10:798 pubmed publisher |
Pangallo J, Kiladjian J, Cassinat B, Renneville A, Taylor J, Polaski J, et al. Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations. Blood. 2020;135:1032-1043 pubmed publisher |
Chivukula R, Montoro D, Leung H, Yang J, Shamseldin H, Taylor M, et al. A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nat Med. 2020;26:244-251 pubmed publisher |
Kabayama H, Takeuchi M, Tokushige N, Muramatsu S, Kabayama M, Fukuda M, et al. An ultra-stable cytoplasmic antibody engineered for in vivo applications. Nat Commun. 2020;11:336 pubmed publisher |
Chang J, Chen X, Wang R, Shi R, Wang X, Lu W, et al. High-Throughput Screening Identifies Two Novel Small Molecule Enhancers of Recombinant Protein Expression. Molecules. 2020;25: pubmed publisher |
Fei Y, Jin Y, Zhao X, Wang Y, Qian J, Su L, et al. The Relative Permittivity Changes of EGF by 50 Hz MF Exposure Neither Affect the Interaction of EGF With EGFR Nor Its Biological Effects. Bioelectromagnetics. 2020;41:241-246 pubmed publisher |
Ashcroft S, Bass J, Kazi A, Atherton P, Philp A. The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts. Am J Physiol Cell Physiol. 2020;318:C536-C541 pubmed publisher |
Majhi P, Sharma A, Roberts A, Daniele E, Majewski A, Chuong L, et al. Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Environ Health Perspect. 2020;128:17002 pubmed publisher |
Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, et al. The Roles of GSK-3β in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma. Theranostics. 2020;10:1230-1244 pubmed publisher |
Mader J, Huber J, Bonn F, Dötsch V, Rogov V, Bremm A. Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding. J Biol Chem. 2020;295:2160-2174 pubmed publisher |
Cui J, Wang H, Medina R, Zhang Q, Xu C, Indig I, et al. Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma. Cancers (Basel). 2020;12: pubmed publisher |
Hanniford D, Ulloa Morales A, Karz A, Berzoti Coelho M, Moubarak R, Sánchez Sendra B, et al. Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Cancer Cell. 2020;37:55-70.e15 pubmed publisher |
Benhadou F, Glitzner E, Brisebarre A, Swedlund B, Song Y, Dubois C, et al. Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease. Sci Adv. 2020;6:eaax5849 pubmed publisher |
Xu D, Wang W, Bian T, Yang W, Shao M, Yang H. Increased expression of O-GlcNAc transferase (OGT) is a biomarker for poor prognosis and allows tumorigenesis and invasion in colon cancer. Int J Clin Exp Pathol. 2019;12:1305-1314 pubmed |
Osaki T, Uzel S, Kamm R. On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease. Nat Protoc. 2020;15:421-449 pubmed publisher |
Halmai J, Deng P, Gonzalez C, Coggins N, Cameron D, Carter J, et al. Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. Nucleic Acids Res. 2020;48:2372-2387 pubmed publisher |
Arias Arias J, MacPherson D, Hill M, Hardy J, Mora Rodriguez R. A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. J Biol Chem. 2020;295:2212-2226 pubmed publisher |
Escoll M, Lastra D, Pajares M, Robledinos Antón N, Rojo A, Fernández Ginés R, et al. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Redox Biol. 2020;30:101425 pubmed publisher |
Roberston M, Raghunathan S, Potaman V, Zhang F, Stewart M, McConnell B, et al. CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression. FASEB J. 2020;34:555-570 pubmed publisher |
Mugahid D, Kalocsay M, Liu X, Gruver J, Peshkin L, Kirschner M. YAP regulates cell size and growth dynamics via non-cell autonomous mediators. elife. 2020;9: pubmed publisher |
Protasoni M, Pérez Pérez R, Lobo Jarne T, Harbour M, Ding S, Peñas A, et al. Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J. 2020;39:e102817 pubmed publisher |
Thomas J, Polaski J, Feng Q, De Neef E, Hoppe E, McSharry M, et al. RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons. Nat Genet. 2020;52:84-94 pubmed publisher |
Yoo H, Lee Y, Park C, Son D, Choi D, Park J, et al. Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function. Cell Death Dis. 2020;11:14 pubmed publisher |
Gonzalez P, González Fernández C, Campos Martín Y, Mollejo M, Carballosa Gautam M, Marcillo A, et al. Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord. Cell Mol Life Sci. 2020;: pubmed publisher |
Yu L, Teoh S, Ensink E, Ogrodzinski M, Yang C, Vazquez A, et al. Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells. Cancer Metab. 2019;7:13 pubmed publisher |
Ruiz G, Valencia González H, Perez Montiel D, Muñoz F, Ocadiz Delgado R, Fernandez Retana J, et al. Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cell Line. Stem Cells Int. 2019;2019:7683817 pubmed publisher |
Serçin O, Reither S, Roidos P, Ballin N, Palikyras S, Baginska A, et al. A solid-phase transfection platform for arrayed CRISPR screens. Mol Syst Biol. 2019;15:e8983 pubmed publisher |
Huang Y, Fan C, Hsu N, Chiu N, Wu C, Chang C, et al. Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. Nano Lett. 2019;: pubmed publisher |
Manuel A, Walla M, Dorn M, Tanis R, Piroli G, Frizzell N. Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte. Free Radic Biol Med. 2019;: pubmed publisher |
Zhang H, Christensen C, Dries R, Oser M, Deng J, Diskin B, et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2019;: pubmed publisher |
Meng N, Glorieux C, Zhang Y, Liang L, Zeng P, Lu W, et al. Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells. Cancers (Basel). 2019;12: pubmed publisher |
Wilson T, Clare S, Mikulin J, Johnson C, Harcourt K, Lyons P, et al. Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection. Immunology. 2020;159:393-403 pubmed publisher |
Bodakuntla S, Janke C, Magiera M. Knocking Out Multiple Genes in Cultured Primary Neurons to Study Tubulin Posttranslational Modifications. Methods Mol Biol. 2020;2101:327-351 pubmed publisher |
Almeida A, Drpic D, Okada N, Bravo J, Madureira M, Maiato H. Functional Dissection of Mitosis Using Immortalized Fibroblasts from the Indian Muntjac, a Placental Mammal with Only Three Chromosomes. Methods Mol Biol. 2020;2101:247-266 pubmed publisher |
Üretmen Kagıalı Z, Saner N, Akdag M, Sanal E, Degirmenci B, Mollaoglu G, et al. CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis. Life Sci Alliance. 2020;3: pubmed publisher |
Jin J, Wang W, Ai S, Liu W, Song Y, Luo Z, et al. Enterovirus 71 Represses Interleukin Enhancer-Binding Factor 2 Production and Nucleus Translocation to Antagonize ILF2 Antiviral Effects. Viruses. 2019;12: pubmed publisher |
Wang Q, Yan S, Chu D, Xie Y, Wang C, Zhang J, et al. Silencing of Long Non-coding RNA RP1-93H18.6 Acts as a Tumor Suppressor in Cervical Cancer through the Blockade of the PI3K/Akt Axis. Mol Ther Nucleic Acids. 2019;19:304-317 pubmed publisher |
Marchesin V, Pérez Martí A, Le Meur G, Pichler R, Grand K, Klootwijk E, et al. Molecular Basis for Autosomal-Dominant Renal Fanconi Syndrome Caused by HNF4A. Cell Rep. 2019;29:4407-4421.e5 pubmed publisher |
Peng Y, Yang T, Tang X, Chen F, Wang S. Construction of an Inducible CRISPR/Cas9 System for CXCR4 Gene and Demonstration of its Effects on MKN-45 Cells. Cell Biochem Biophys. 2019;: pubmed publisher |
Park E, Scott P, Clutario K, Cassidy K, Zhan K, Gerber S, et al. WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. J Cell Biol. 2020;219: pubmed publisher |
Paul B, Tesfay L, Winkler C, Torti F, Torti S. Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes. Sci Rep. 2019;9:19634 pubmed publisher |
Bucko P, Lombard C, Rathbun L, Garcia I, Bhat A, Wordeman L, et al. Subcellular drug targeting illuminates local kinase action. elife. 2019;8: pubmed publisher |
Ng S, Rideout W, Akama Garren E, Bhutkar A, Mercer K, Schenkel J, et al. CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Proc Natl Acad Sci U S A. 2019;: pubmed publisher |
Al Kershi S, Bhayadia R, Ng M, Verboon L, Emmrich S, Gack L, et al. The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia. Blood Adv. 2019;3:4252-4263 pubmed publisher |
Liu L, Xie B, Fan M, Candas Green D, Jiang J, Wei R, et al. Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. Dev Cell. 2019;: pubmed publisher |
Nguyen T, Kabotyanski E, Reineke L, Shao J, Xiong F, Lee J, et al. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020;48:2621-2642 pubmed publisher |
Ashrafi G, de Juan Sanz J, Farrell R, Ryan T. Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission. Neuron. 2019;: pubmed publisher |
Blum W, Henzi T, Pecze L, Diep K, Bochet C, Schwaller B. The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cells in vitro and in vivo. Oncotarget. 2019;10:6944-6956 pubmed publisher |
Chen C, Yu W, Tober J, Gao P, He B, Lee K, et al. Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells. Cell Rep. 2019;29:4200-4211.e7 pubmed publisher |
Bell E, Coelho P, Ratcliffe C, Rajadurai C, Peschard P, Vaillancourt R, et al. LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion. Cell Rep. 2019;29:4053-4068.e6 pubmed publisher |
Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed publisher |
Rubio R, Mohr I. Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Proc Natl Acad Sci U S A. 2019;: pubmed publisher |
Cortez L, Brown A, Dennis M, Collins C, Brown A, Mitchell D, et al. APOBEC3A is a prominent cytidine deaminase in breast cancer. PLoS Genet. 2019;15:e1008545 pubmed publisher |
Thongararm P, Fedeles B, Khumsubdee S, Armijo A, Kim L, Thiantanawat A, et al. Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the gpt Delta Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol. 2019;: pubmed publisher |
Chen Z, Wu W, Huang Y, Xie L, Li Y, Chen H, et al. RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT. J Cancer. 2019;10:6837-6847 pubmed publisher |
Czarnek M, Bereta J. Proteolytic Processing of Neuregulin 2. Mol Neurobiol. 2019;: pubmed publisher |
Lough K, Byrd K, Descovich C, Spitzer D, Bergman A, BEAUDOIN G, et al. Telophase correction refines division orientation in stratified epithelia. elife. 2019;8: pubmed publisher |
Luo Q, Wu X, Chang W, Zhao P, Nan Y, Zhu X, et al. ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness. Cell Death Differ. 2019;: pubmed publisher |
Qin L, Chen J, Tang L, Zuo T, Chen H, Gao R, et al. Significant Role of Dicer and miR-223 in Adipose Tissue of Polycystic Ovary Syndrome Patients. Biomed Res Int. 2019;2019:9193236 pubmed publisher |
Salameti V, Bhosale P, Ames Draycott A, Sipilä K, Watt F. NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis. Oncotarget. 2019;10:6791-6804 pubmed publisher |
Wei J, Long L, Zheng W, Dhungana Y, Lim S, Guy C, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. 2019;576:471-476 pubmed publisher |
Casanova M, Moscatelli M, Chauvière L, Huret C, Samson J, Liyakat Ali T, et al. A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Nat Commun. 2019;10:5652 pubmed publisher |
Douglas T, Saleh M. Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death. Cell Rep. 2019;29:3652-3663.e5 pubmed publisher |
Yang Y, Ren Z, Xu F, Meng Y, Zhang Y, Ai N, et al. Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells. Cell Rep. 2019;29:3374-3384.e5 pubmed publisher |
Alshafie W, Francis V, Bednarz K, Pan Y, Stroh T, McPherson P. Regulated resurfacing of a somatostatin receptor storage compartment fine-tunes pituitary secretion. J Cell Biol. 2020;219: pubmed publisher |
Zhang Q, Wu C, Fan Y, Xu T, Meng Q, Wang S, et al. Nucleic acid-targeted pathogen reduction technique in red blood cells by UV-generated oxygen radicals for optimising recipient safety. Transfus Med. 2019;: pubmed publisher |
Huang Z, Zhang Y, Li H, Zhou Y, Zhang Q, Chen R, et al. Vitamin D promotes the cisplatin sensitivity of oral squamous cell carcinoma by inhibiting LCN2-modulated NF-κB pathway activation through RPS3. Cell Death Dis. 2019;10:936 pubmed publisher |
Muthu M, Kumar R, Syed Khaja A, Gilthorpe J, Persson J, Nordstrom A. GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism. Cancers (Basel). 2019;11: pubmed publisher |
Jia J, Claude Taupin A, Gu Y, Choi S, Peters R, Bissa B, et al. Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal. Dev Cell. 2019;: pubmed publisher |
Crochemore C, Fernandez Molina C, Montagne B, Salles A, Ricchetti M. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Nat Commun. 2019;10:5576 pubmed publisher |
Lehmann M, Lukonin I, Noe F, Schmoranzer J, Clementi C, Loerke D, et al. Nanoscale coupling of endocytic pit growth and stability. Sci Adv. 2019;5:eaax5775 pubmed publisher |
Kim S, Bolatkan A, Kaneko S, Ikawa N, Asada K, Komatsu M, et al. Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma. Biomolecules. 2019;9: pubmed publisher |
Satoh T, Mellett M, Meier Schiesser B, Fenini G, Otsuka A, Beer H, et al. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. J Clin Invest. 2019;: pubmed publisher |
Ysselstein D, Nguyen M, Young T, Severino A, Schwake M, Merchant K, et al. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Nat Commun. 2019;10:5570 pubmed publisher |
Cloux A, Aubry D, Heulot M, Widmann C, ElMokh O, Piacente F, et al. Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent. Oncotarget. 2019;10:6723-6738 pubmed publisher |
Carter R, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, et al. Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Cell Death Dis. 2019;10:912 pubmed publisher |
Manjunath H, Zhang H, Rehfeld F, Han J, Chang T, Mendell J. Suppression of Ribosomal Pausing by eIF5A Is Necessary to Maintain the Fidelity of Start Codon Selection. Cell Rep. 2019;29:3134-3146.e6 pubmed publisher |
Chen X, Tasca F, Wang Q, Liu J, Janssen J, Brescia M, et al. Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking. Nucleic Acids Res. 2019;: pubmed publisher |
Yokoi A, Villar Prados A, Oliphint P, Zhang J, Song X, De Hoff P, et al. Mechanisms of nuclear content loading to exosomes. Sci Adv. 2019;5:eaax8849 pubmed publisher |
Friman E, Deluz C, Meireles Filho A, Govindan S, Gardeux V, Deplancke B, et al. Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle. elife. 2019;8: pubmed publisher |
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, et al. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nat Med. 2019;25:1938-1947 pubmed publisher |
Van Duzer A, Taniguchi S, Elhance A, Tsujikawa T, Oshimori N. ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival. Life Sci Alliance. 2019;2: pubmed publisher |
Johnston B, Pringle E, McCormick C. KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication. PLoS Pathog. 2019;15:e1008185 pubmed publisher |
Luo H, Zhu G, Xu J, Lai Q, Yan B, Guo Y, et al. HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice. Cancer Cell. 2019;36:645-659.e8 pubmed publisher |
Chylinski K, Hubmann M, Hanna R, Yanchus C, Michlits G, Uijttewaal E, et al. CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci. Nat Commun. 2019;10:5454 pubmed publisher |
Dudek A, Zabaleta N, Zinn E, Pillay S, Zengel J, Porter C, et al. GPR108 Is a Highly Conserved AAV Entry Factor. Mol Ther. 2019;: pubmed publisher |
Borkowska P, Zielinska A, Paul Samojedny M, Stojko R, Kowalski J. Evaluation of reference genes for quantitative real-time PCR in Wharton's Jelly-derived mesenchymal stem cells after lentiviral transduction and differentiation. Mol Biol Rep. 2019;: pubmed publisher |
Trigg R, Lee L, Prokoph N, Jahangiri L, Reynolds C, Amos Burke G, et al. The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status. Nat Commun. 2019;10:5428 pubmed publisher |
Xie S, Armendariz D, Zhou P, Duan J, Hon G. Global Analysis of Enhancer Targets Reveals Convergent Enhancer-Driven Regulatory Modules. Cell Rep. 2019;29:2570-2578.e5 pubmed publisher |
Luong P, Li Q, Chen P, Wrighton P, Chang D, Dwyer S, et al. A quantitative single-cell assay for retrograde membrane traffic enables rapid detection of defects in cellular organization. Mol Biol Cell. 2019;:mbcE19070375 pubmed publisher |
Jiang H, Leung C, Tahan S, Wang D. Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1. elife. 2019;8: pubmed publisher |
Gambardella L, McManus S, Moignard V, Sebukhan D, Delaune A, Andrews S, et al. BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium. Development. 2019;146: pubmed publisher |
Linaro D, Vermaercke B, Iwata R, Ramaswamy A, Libé Philippot B, Boubakar L, et al. Xenotransplanted Human Cortical Neurons Reveal Species-Specific Development and Functional Integration into Mouse Visual Circuits. Neuron. 2019;104:972-986.e6 pubmed publisher |
Morton A, Dogan Artun N, Faber Z, Macleod G, Bartels C, Piazza M, et al. Functional Enhancers Shape Extrachromosomal Oncogene Amplifications. Cell. 2019;179:1330-1341.e13 pubmed publisher |
Pezeshkian N, Groves N, Van Engelenburg S. Single-molecule imaging of HIV-1 envelope glycoprotein dynamics and Gag lattice association exposes determinants responsible for virus incorporation. Proc Natl Acad Sci U S A. 2019;116:25269-25277 pubmed publisher |
Wang W, Huang D, Ren J, Li R, Feng Z, Guan C, et al. Optogenetic control of mesenchymal cell fate towards precise bone regeneration. Theranostics. 2019;9:8196-8205 pubmed publisher |
Harding H, Ordonez A, Allen F, Parts L, Inglis A, Williams R, et al. The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells. elife. 2019;8: pubmed publisher |
Khabir M, Aliche A, Sureau C, Blanchet M, Labonte P. HDV alters the autophagy process to promote its genome replication. J Virol. 2019;: pubmed publisher |
Gülcüler Balta G, Monzel C, Kleber S, Beaudouin J, Balta E, Kaindl T, et al. 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Cell Rep. 2019;29:2295-2306.e6 pubmed publisher |
Larson G, Tran V, Yu S, Cai Y, Higgins C, Smith D, et al. EPS8 Facilitates Uncoating of Influenza A Virus. Cell Rep. 2019;29:2175-2183.e4 pubmed publisher |
Palmer A, Chidley C, Sorger P. A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity. elife. 2019;8: pubmed publisher |
Sung Y, Jin P, Chu L, Hsu F, Wang M, Chang C, et al. Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies. Nat Nanotechnol. 2019;14:1160-1169 pubmed publisher |
Wang S, Crisman L, Miller J, Datta I, Gulbranson D, Tian Y, et al. Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. J Biol Chem. 2019;294:19988-19996 pubmed publisher |
Silvério Alves R, Gomes A, Kurochkin I, Moore K, Pereira C. Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors. J Vis Exp. 2019;: pubmed publisher |
Huang Y, Mouttet B, Warnatz H, Risch T, Rietmann F, Frommelt F, et al. The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Cancer Cell. 2019;36:630-644.e9 pubmed publisher |
Del Corpo O, Goguen R, Malard C, Daher A, Colby Germinario S, Scarborough R, et al. A U1i RNA that Enhances HIV-1 RNA Splicing with an Elongated Recognition Domain Is an Optimal Candidate for Combination HIV-1 Gene Therapy. Mol Ther Nucleic Acids. 2019;18:815-830 pubmed publisher |
Zhang J, Luo A, Huang F, Gong T, Liu Z. SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4. Cancer Lett. 2020;469:390-398 pubmed publisher |
Oser M, Sabet A, Gao W, Chakraborty A, Schinzel A, Jennings R, et al. The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Genes Dev. 2019;33:1718-1738 pubmed publisher |
Zhai W, Zhou X, Du J, Gao Y. In vitro assay for the development of small molecule inhibitors targeting PD-1/PD-L1. Methods Enzymol. 2019;629:361-381 pubmed publisher |
Buehler J, Carpenter E, Zeltzer S, Igarashi S, Rak M, Mikell I, et al. Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency. PLoS Pathog. 2019;15:e1008037 pubmed publisher |
Nagati J, Xu M, Garcia T, Comerford S, Hammer R, Garcia J. A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling. PLoS ONE. 2019;14:e0225105 pubmed publisher |
Chan K, Robert F, Oertlin C, Kapeller Libermann D, Avizonis D, Gutierrez J, et al. eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nat Commun. 2019;10:5151 pubmed publisher |
An Z, Liu P, Zheng J, Si C, Li T, Chen Y, et al. Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. Cell Rep. 2019;29:1986-2000.e8 pubmed publisher |
Gupta S, Sharp R, Hofferek C, Kuai L, Dorn G, Wang J, et al. NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells. Cell Rep. 2019;29:1862-1877.e7 pubmed publisher |
Wang L, Shen E, Luo L, Rabe H, Wang Q, Yin J, et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep. 2019;29:1848-1861.e6 pubmed publisher |
Resnick R, Wong C, Hamm D, Bennett S, Skene P, Hake S, et al. DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression. Cell Rep. 2019;29:1812-1820.e5 pubmed publisher |
Zheng W, Zhang H, Zhao D, Zhang J, Pollard J. Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression. Cell Rep. 2019;29:1747-1755.e4 pubmed publisher |
Pouliot G, Degar J, Hinze L, Kochupurakkal B, Vo C, Burns M, et al. Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. PLoS ONE. 2019;14:e0221288 pubmed publisher |
Hu Y, Zhang F, Zhong W, Liu Y, He Q, Yang M, et al. Transplantation of neural scaffolds consisting of dermal fibroblast-reprogrammed neurons and 3D silk fibrous materials promotes the repair of spinal cord injury. J Mater Chem B. 2019;7:7525-7539 pubmed publisher |
Garland K, Sevimli S, Kilchrist K, Duvall C, Cook R, Wilson J. Microparticle Depots for Controlled and Sustained Release of Endosomolytic Nanoparticles. Cell Mol Bioeng. 2019;12:429-442 pubmed publisher |
Price J, Russo D, Ji D, Chavez R, DiPeso L, Lee A, et al. IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. MBio. 2019;10: pubmed publisher |
Chiarella A, Butler K, Gryder B, Lu D, Wang T, Yu X, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2019;: pubmed publisher |
Millen S, Gross C, Donhauser N, Mann M, Peloponese J, Thoma Kress A. Collagen IV (COL4A1, COL4A2), a Component of the Viral Biofilm, Is Induced by the HTLV-1 Oncoprotein Tax and Impacts Virus Transmission. Front Microbiol. 2019;10:2439 pubmed publisher |
He S, Wu W, Wan Y, Nandakumar K, Cai X, Tang X, et al. GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein. Front Pharmacol. 2019;10:1230 pubmed publisher |
Nano M, Gemble S, Simon A, Pennetier C, Fraisier V, Marthiens V, et al. Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells. Curr Biol. 2019;29:3937-3945.e7 pubmed publisher |
Mu X, Bai L, Xu Y, Wang J, Lu H. Protein targeting chimeric molecules specific for dual bromodomain 4 (BRD4) and Polo-like kinase 1 (PLK1) proteins in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2019;: pubmed publisher |
Lana M, Strauss B. Production of Lentivirus for the Establishment of CAR-T Cells. Methods Mol Biol. 2020;2086:61-67 pubmed publisher |
Chen B, Huang S, Pisanic Ii T, Stark A, Tao Y, Cheng B, et al. Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer. EBioMedicine. 2019;49:118-132 pubmed publisher |
Rom A, Melamed L, Gil N, Goldrich M, Kadir R, Golan M, et al. Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability. Nat Commun. 2019;10:5092 pubmed publisher |
Russo M, Crisafulli G, Sogari A, Reilly N, Arena S, Lamba S, et al. Adaptive mutability of colorectal cancers in response to targeted therapies. Science. 2019;: pubmed publisher |
Xu D, Liang S, Yang H, Bruggmann R, Berezowska S, Yang Z, et al. CRISPR screening identifies WEE1 as a combination target for standard chemotherapy in malignant pleural mesothelioma. Mol Cancer Ther. 2019;: pubmed publisher |
Ting T, Goralski M, Klein K, Wang B, Kim J, Xie Y, et al. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15. Cell Rep. 2019;29:1499-1510.e6 pubmed publisher |
Jia R, Bonifacino J. Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3. elife. 2019;8: pubmed publisher |
Crutcher E, Pal R, Naini F, Zhang P, Laugsch M, Kim J, et al. mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome. Sci Rep. 2019;9:15935 pubmed publisher |
Ten Hoeve A, Hakimi M, Barragan A. Sustained Egr-1 Response via p38 MAP Kinase Signaling Modulates Early Immune Responses of Dendritic Cells Parasitized by Toxoplasma gondii. Front Cell Infect Microbiol. 2019;9:349 pubmed publisher |
Peskova L, Cerná K, Oppelt J, Mraz M, Bárta T. Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts. Sci Rep. 2019;9:15759 pubmed publisher |
Wörthmüller J, Salicio V, Oberson A, Blum W, Schwaller B. Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin. Int J Mol Sci. 2019;20: pubmed publisher |
Chen T, Zhang B, Ziegenhals T, Prusty A, Fröhler S, Grimm C, et al. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLoS Genet. 2019;15:e1008460 pubmed publisher |
Wei Z, Meng X, El Fatimy R, Sun B, Mai D, Zhang J, et al. Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways. Neurobiol Dis. 2019;134:104617 pubmed publisher |
Juin A, Spence H, Martin K, McGhee E, Neilson M, Cutiongco M, et al. N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis. Dev Cell. 2019;51:431-445.e7 pubmed publisher |
Xiang Q, Ju H, Nicholas J. USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue. J Virol. 2019;: pubmed publisher |
Tam O, Rozhkov N, Shaw R, Kim D, Hubbard I, Fennessey S, et al. Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia. Cell Rep. 2019;29:1164-1177.e5 pubmed publisher |
Cook N, Pjanic M, Emmerich A, Rao A, Hetty S, Knowles J, et al. CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation. BMC Endocr Disord. 2019;19:115 pubmed publisher |
Choi H, Madhu V, Shapiro I, Risbud M. Nucleus pulposus primary cilia alter their length in response to changes in extracellular osmolarity but do not control TonEBP-mediated osmoregulation. Sci Rep. 2019;9:15469 pubmed publisher |
Jiang J, Srivastava S, Seim G, Pavlova N, King B, Zou L, et al. Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion. J Biol Chem. 2019;294:18674-18684 pubmed publisher |
Marbaix A, Chehade G, Noel G, Morsomme P, Vertommen D, Bommer G, et al. Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Biochem J. 2019;476:3033-3052 pubmed publisher |
Schmidt H, Barreau A, Rohatgi R. Phase separation-deficient TDP43 remains functional in splicing. Nat Commun. 2019;10:4890 pubmed publisher |
Lee J, Ghonime M, Cassady K. STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation. Mol Ther Oncolytics. 2019;15:91-100 pubmed publisher |
Godet I, Shin Y, Ju J, Ye I, Wang G, Gilkes D. Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis. Nat Commun. 2019;10:4862 pubmed publisher |
Shohat S, Shifman S. Genes essential for embryonic stem cells are associated with neurodevelopmental disorders. Genome Res. 2019;29:1910-1918 pubmed publisher |
Yan D, Dong W, He Q, Yang M, Huang L, Kong J, et al. Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation. EBioMedicine. 2019;48:316-331 pubmed publisher |
Zheng B, Wang X, Liu Y, Li Y, Long S, Gu C, et al. Japanese Encephalitis Virus infection induces inflammation of swine testis through RIG-I-NF-ĸB signaling pathway. Vet Microbiol. 2019;238:108430 pubmed publisher |
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574:553-558 pubmed publisher |
Sun J, Zhang D, Gao C, Zhang Y, Dai Q. Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN. Med Sci Monit Basic Res. 2019;25:218-228 pubmed publisher |
Gehring T, Erdmann T, Rahm M, Graß C, Flatley A, O Neill T, et al. MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Cell Rep. 2019;29:873-888.e10 pubmed publisher |
Wible D, Chao H, Tang D, Bratton S. ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. Cell Discov. 2019;5:42 pubmed publisher |
Freyre C, Rauher P, Ejsing C, Klemm R. MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Mol Cell. 2019;76:811-825.e14 pubmed publisher |
Feldman D, Singh A, Schmid Burgk J, Carlson R, Mezger A, Garrity A, et al. Optical Pooled Screens in Human Cells. Cell. 2019;179:787-799.e17 pubmed publisher |
Crook Z, Sevilla G, Mhyre A, Olson J. Mammalian Surface Display Screening of Diverse Cystine-Dense Peptide Libraries for Difficult-to-Drug Targets. Methods Mol Biol. 2020;2070:363-396 pubmed publisher |
Ma D, Liu H, Qin Y, Tian Z, Li S, Liang N. KLF8 overexpression promotes the growth of human lung cancer cells by promoting the expression of JMJD2A. Cancer Cell Int. 2019;19:258 pubmed publisher |
Srikantan S, Deng Y, Cheng Z, Luo A, Qin Y, Gao Q, et al. The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner. Nat Commun. 2019;10:4720 pubmed publisher |
Lorenz D, Sathe S, Einstein J, Yeo G. Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base specific resolution. RNA. 2019;: pubmed publisher |
Zhang L, Zhou Q, Qiu Q, Hou L, Wu M, Li J, et al. CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer. Mol Cancer. 2019;18:144 pubmed publisher |
Seligson N, Stets C, Demoret B, Awasthi A, Grosenbacher N, Shakya R, et al. Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma. Oncotarget. 2019;10:5671-5679 pubmed publisher |
Hoshino A, Wang W, Wada S, McDermott Roe C, Evans C, Gosis B, et al. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019;575:375-379 pubmed publisher |
Huang Q, Zhang H, Liao Z. Carboxypeptidase A6 Promotes the Proliferation and Migration of Hepatocellular Carcinoma by Up-regulating AKT Signaling Pathway. Curr Med Sci. 2019;39:727-733 pubmed publisher |
Cai D, Li J, Liu D, Hong S, Qiao Q, Sun Q, et al. Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy. Cell Mol Immunol. 2019;: pubmed publisher |
Faust J, Millis B, Tyska M. Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli. Curr Biol. 2019;29:3457-3465.e3 pubmed publisher |
Miklas J, Clark E, Levy S, Detraux D, Leonard A, Beussman K, et al. TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Nat Commun. 2019;10:4671 pubmed publisher |
Kuroda T, Ogiwara H, Sasaki M, Takahashi K, Yoshida H, Kiyokawa T, et al. Therapeutic preferability of gemcitabine for ARID1A-deficient ovarian clear cell carcinoma. Gynecol Oncol. 2019;155:489-498 pubmed publisher |
Smith V, Dietz A, Henz K, Bruecher D, Jackson R, Kowald L, et al. Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma. Haematologica. 2019;: pubmed publisher |
Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer B, Schulze M, et al. Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue. Cardiovasc Res. 2019;: pubmed publisher |
Scheefhals N, Catsburg L, Westerveld M, Blanpied T, Hoogenraad C, MacGillavry H. Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5. Cell Rep. 2019;29:258-269.e8 pubmed publisher |
Hirukawa A, Singh S, Wang J, Rennhack J, Swiatnicki M, Sanguin Gendreau V, et al. Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy. Cell Rep. 2019;29:249-257.e8 pubmed publisher |
Puleo J, Parker S, Roman M, Watson A, Eliato K, Peng L, et al. Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions. J Cell Biol. 2019;218:4215-4235 pubmed publisher |
Atsuta Y, Tomizawa R, Levin M, Tabin C. L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019;116:21592-21601 pubmed publisher |
Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, et al. Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients. EMBO Mol Med. 2019;11:e10547 pubmed publisher |
Mercadante D, Crowley E, Manning A. Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations. J Vis Exp. 2019;: pubmed publisher |
Li X, Han L, Nookaew I, Mannen E, Silva M, Almeida M, et al. Stimulation of Piezo1 by mechanical signals promotes bone anabolism. elife. 2019;8: pubmed publisher |
Marques P, Kamitz A, Bartolomé A, Burillo J, Martínez H, Jimenez B, et al. Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status. Cell Death Discov. 2019;5:138 pubmed publisher |
Smeester B, Slipek N, Pomeroy E, Bomberger H, Shamsan G, Peterson J, et al. SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis. Oncogene. 2019;: pubmed publisher |
Didychuk A, Castañeda A, Kushnir L, Huang C, Glaunsinger B. Conserved CxnC motifs in Kaposi's sarcoma-associated herpesvirus ORF66 are required for viral late gene expression and are essential for its interaction with ORF34. J Virol. 2019;: pubmed publisher |
Guo L, Wang R, Zhang K, Yuan J, Wang J, Wang X, et al. A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation. J Cell Biol. 2019;218:3773-3794 pubmed publisher |
Nicholson H, Tariq Z, Housden B, Jennings R, Stransky L, Perrimon N, et al. HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species. Sci Signal. 2019;12: pubmed publisher |
Gomes A, Ilter D, Low V, Rosenzweig A, Shen Z, Schild T, et al. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019;36:402-417.e13 pubmed publisher |
Stine R, Sakers A, Teslaa T, Kissig M, Stine Z, Kwon C, et al. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Cell Stem Cell. 2019;25:830-845.e8 pubmed publisher |
Perl A, O Connor C, Fa P, Mayca Pozo F, Zhang J, Zhang Y, et al. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45). J Biol Chem. 2019;294:17043-17059 pubmed publisher |
Jang J, Han D, Golkaram M, Audouard M, Liu G, Bridges D, et al. Control over single-cell distribution of G1 lengths by WNT governs pluripotency. PLoS Biol. 2019;17:e3000453 pubmed publisher |
Huang K, O Neill K, Li J, Zhou W, Han N, Pang X, et al. BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis. Cell Res. 2019;29:942-952 pubmed publisher |
Liang J, Zhao H, Diplas B, Liu S, Liu J, Wang D, et al. Genome-wide CRISPR-Cas9 screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition. Cancer Res. 2019;: pubmed publisher |
Nagler A, Vredevoogd D, Alon M, Cheng P, Trabish S, Kalaora S, et al. A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma. Pigment Cell Melanoma Res. 2019;: pubmed publisher |
Mollazadeh S, Fazly Bazzaz B, Neshati V, de Vries A, Naderi Meshkin H, Mojarad M, et al. T-Box20 inhibits osteogenic differentiation in adipose-derived human mesenchymal stem cells: the role of T-Box20 on osteogenesis. J Biol Res (Thessalon). 2019;26:8 pubmed publisher |
Ko T, Sharma R, Li S. Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression. Oncogene. 2019;: pubmed publisher |
Lim C, Davis O, Shin H, Zhang J, Berdan C, Jiang X, et al. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nat Cell Biol. 2019;21:1206-1218 pubmed publisher |
Mair B, Aldridge P, Atwal R, Philpott D, Zhang M, Masud S, et al. High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Nat Biomed Eng. 2019;3:796-805 pubmed publisher |
Velayutham T, Kumar S, Zhang X, Kose N, Walker D, Winslow G, et al. Ehrlichia chaffeensis Outer Membrane Protein 1-Specific Human Antibody-Mediated Immunity Is Defined by Intracellular TRIM21-Dependent Innate Immune Activation and Extracellular Neutralization. Infect Immun. 2019;87: pubmed publisher |
Tang X, Fu X, Liu Y, Yu D, Cai S, Yang C. Blockade of glutathione metabolism in IDH1-mutated glioma. Mol Cancer Ther. 2019;: pubmed publisher |
Stantchev T, Zack Taylor A, Mattson N, Strebel K, Broder C, Clouse K. Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages. Viruses. 2019;11: pubmed publisher |
Chan K, Tong A, Brown K, Mero P, Moffat J. Pooled CRISPR-Based Genetic Screens in Mammalian Cells. J Vis Exp. 2019;: pubmed publisher |
Guieze R, Liu V, Rosebrock D, Jourdain A, Hernández Sánchez M, Martinez Zurita A, et al. Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Cancer Cell. 2019;36:369-384.e13 pubmed publisher |
Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, et al. Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Nat Commun. 2019;10:4297 pubmed publisher |
Chang C, Chen C, Grauffel C, Pien Y, Lim C, Tsai S, et al. Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α. Nat Commun. 2019;10:4307 pubmed publisher |
Feng W, Simpson D, Carvajal Garcia J, Price B, Kumar R, Mose L, et al. Genetic determinants of cellular addiction to DNA polymerase theta. Nat Commun. 2019;10:4286 pubmed publisher |
Heden T, Johnson J, Ferrara P, Eshima H, Verkerke A, Wentzler E, et al. Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv. 2019;5:eaax8352 pubmed publisher |
Oleinik N, Kim J, Roth B, Selvam S, Gooz M, Johnson R, et al. Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Sci Adv. 2019;5:eaax1978 pubmed publisher |
Trümper V, von Knethen A, Preuß A, Ermilov E, Hackbarth S, Kuchler L, et al. Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells. Theranostics. 2019;9:5444-5463 pubmed publisher |
Merola J, Reschke M, Pierce R, Qin L, Spindler S, Baltazar T, et al. Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression. JCI Insight. 2019;4: pubmed publisher |
Roczniak Ferguson A, Ferguson S. Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis. Life Sci Alliance. 2019;2: pubmed publisher |
Vande Walle L, Stowe I, Sácha P, Lee B, Demon D, Fossoul A, et al. MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. PLoS Biol. 2019;17:e3000354 pubmed publisher |
Tan W, Xu T, Zhou Z, Lv X, Liu J, Zhang W, et al. TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer. Oncol Rep. 2019;: pubmed publisher |
Rudenko L, Wallrabe H, Periasamy A, Siller K, Švindrych Z, Seward M, et al. Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-β Oligomers. J Alzheimers Dis. 2019;71:1125-1138 pubmed publisher |
Hoffman H, Fernandez M, Groves N, Freed E, Van Engelenburg S. Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions. J Biol Chem. 2019;294:16266-16281 pubmed publisher |
van Senten J, Bebelman M, Fan T, Heukers R, Bergkamp N, van Gasselt P, et al. The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties. J Biol Chem. 2019;294:16297-16308 pubmed publisher |
Zhang Y, Meng N, Bao H, Jiang Y, Yang N, Wu K, et al. Circadian gene PER1 senses progesterone signal during human endometrial decidualization. J Endocrinol. 2019;: pubmed publisher |
Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal J, et al. Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. J Cell Mol Med. 2019;23:7785-7795 pubmed publisher |
Hashwah H, Bertram K, Stirm K, Stelling A, Wu C, Kasser S, et al. The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma. EMBO Mol Med. 2019;11:e10576 pubmed publisher |
Zoeller E, PEDRO B, Konen J, Dwivedi B, Rupji M, Sundararaman N, et al. Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes. J Cell Sci. 2019;132: pubmed publisher |
Shi Y, Yu J, Zhang Y, Zhao B, Li Y, Ye Y, et al. RhTyrRS (Y341A), a novel human tyrosyl-tRNA synthetase mutant, stimulates thrombopoiesis through activation of the VEGF-R II/NF-κB pathway. Biochem Pharmacol. 2019;169:113634 pubmed publisher |
Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, et al. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host Microbe. 2019;26:369-384.e8 pubmed publisher |
Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed publisher |
Pozzo E, Tremolanti C, Costa B, Giacomelli C, Milenkovic V, Bader S, et al. Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation. Int J Mol Sci. 2019;20: pubmed publisher |
Giuliano C, Lin A, Girish V, Sheltzer J. Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9. Curr Protoc Mol Biol. 2019;128:e100 pubmed publisher |
Grossi S, Fenini G, Hennig P, Di Filippo M, Beer H. Generation of Knockout Human Primary Keratinocytes by CRISPR/Cas9. Methods Mol Biol. 2019;: pubmed publisher |
Wang S, Ko S, Jo S, Jo H, Han J, Kim Y, et al. Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2. Exp Neurobiol. 2019;28:537-546 pubmed publisher |
Baek H, Kwon Y, Ye D, Cho E, Kwon T, Chun Y. CYP1B1 prevents proteasome-mediated XIAP degradation by inducing PKCε activation and phosphorylation of XIAP. Biochim Biophys Acta Mol Cell Res. 2019;1866:118553 pubmed publisher |
Miao Q, Hill M, Chen F, Mo Q, Ku A, Ramos C, et al. SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. Nat Commun. 2019;10:4042 pubmed publisher |
Beaumatin F, O Prey J, Barthet V, Zunino B, Parvy J, Bachmann A, et al. mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux. Mol Cell. 2019;76:163-176.e8 pubmed publisher |
Bassaganyas L, Popa S, Horlbeck M, Puri C, Stewart S, Campelo F, et al. New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells. J Cell Biol. 2019;218:3861-3879 pubmed publisher |
Tian S, Wu Q, Zhou B, Choi M, Ding B, Yang W, et al. Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Cell Rep. 2019;28:2517-2526.e5 pubmed publisher |
Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, et al. Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses. EMBO J. 2019;38:e102096 pubmed publisher |
Diaz Osterman C, Ozmadenci D, Kleinschmidt E, Taylor K, Barrie A, Jiang S, et al. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. elife. 2019;8: pubmed publisher |
Wang M, Nagle R, Knudsen B, Cress A, Rogers G. Centrosome loss results in an unstable genome and malignant prostate tumors. Oncogene. 2019;: pubmed publisher |
Li S, Karri D, Sanchez Ortiz E, Jaichander P, Bassel Duby R, Liu N, et al. Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells. Dev Cell. 2019;51:89-98.e4 pubmed publisher |
Miyoshi T, Makino T, Moran J. Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition. Mol Cell. 2019;75:1286-1298.e12 pubmed publisher |
Kim S, Kim N, Park S, Jeon Y, Lee J, Yoo S, et al. Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. Autophagy. 2019;:1-21 pubmed publisher |
Han H, Chen N, Huang X, Liu B, Tian J, Lei H. Phosphoinositide 3-kinase δ inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells. J Biol Chem. 2019;294:15408-15417 pubmed publisher |
Meister M, Boedicker C, Linder B, Kogel D, Klingebiel T, Fulda S. Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells. Cancer Lett. 2019;465:1-11 pubmed publisher |
Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, et al. WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Cell Commun Signal. 2019;17:109 pubmed publisher |
Li P, He J, Yang Z, Ge S, Zhang H, Zhong Q, et al. ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression. Autophagy. 2019;:1-14 pubmed publisher |
Kasitinon S, Eskiocak U, Martin M, Bezwada D, Khivansara V, Tasdogan A, et al. TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling. Cell Rep. 2019;28:2293-2305.e9 pubmed publisher |
Naziroglu M, Ciğ B, Yazğan Y, Schwaerzer G, Theilig F, Pecze L. Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin. Sci Rep. 2019;9:12403 pubmed publisher |
Yagensky O, Kohansal Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, et al. Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. elife. 2019;8: pubmed publisher |
Pandori W, Lima T, Mallya S, Kao T, Gov L, Lodoen M. Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes. PLoS Pathog. 2019;15:e1007923 pubmed publisher |
Rasoulouniriana D, Santana Magal N, Gutwillig A, Farhat Younis L, Wine Y, Saperia C, et al. A distinct subset of FcγRI-expressing Th1 cells exert antibody-mediated cytotoxic activity. J Clin Invest. 2019;129:4151-4164 pubmed publisher |
Mayor Ruiz C, Jaeger M, Bauer S, Brand M, Sin C, Hanzl A, et al. Plasticity of the Cullin-RING Ligase Repertoire Shapes Sensitivity to Ligand-Induced Protein Degradation. Mol Cell. 2019;75:849-858.e8 pubmed publisher |
Farzadfard F, Gharaei N, Higashikuni Y, Jung G, Cao J, Lu T. Single-Nucleotide-Resolution Computing and Memory in Living Cells. Mol Cell. 2019;75:769-780.e4 pubmed publisher |
Colic M, Wang G, Zimmermann M, Mascall K, McLaughlin M, Bertolet L, et al. Identifying chemogenetic interactions from CRISPR screens with drugZ. Genome Med. 2019;11:52 pubmed publisher |
Lindtner S, Catta Preta R, Tian H, Su Feher L, Price J, Dickel D, et al. Genomic Resolution of DLX-Orchestrated Transcriptional Circuits Driving Development of Forebrain GABAergic Neurons. Cell Rep. 2019;28:2048-2063.e8 pubmed publisher |
Yoshimitsu M, Hachiman M, Uchida Y, Arima N, Arai A, Kamada Y, et al. Essential thrombocytosis attributed to JAK2-T875N germline mutation. Int J Hematol. 2019;110:584-590 pubmed publisher |
Kim Y, Lee S, Kim S, Jang H, Hwang I, Jin S, et al. Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. Nat Chem Biol. 2019;15:907-916 pubmed publisher |
Schick S, Rendeiro A, Runggatscher K, Ringler A, Boidol B, Hinkel M, et al. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Nat Genet. 2019;51:1399-1410 pubmed publisher |
Zhang K, Li H, Dong S, Liu Y, Wang D, Liu H, et al. Establishment and evaluation of a PRRSV-sensitive porcine endometrial epithelial cell line by transfecting SV40 large T antigen. BMC Vet Res. 2019;15:299 pubmed publisher |
Kercher E, Nath S, Rizvi I, Spring B. Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model. Photochem Photobiol. 2019;: pubmed publisher |
Westrich J, Vermeer D, Silva A, Bonney S, Berger J, Cicchini L, et al. CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression. Oncogene. 2019;: pubmed publisher |
Dewulf J, Gerin I, Rider M, Veiga da Cunha M, van Schaftingen E, Bommer G. The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Biochem J. 2019;476:2427-2447 pubmed publisher |
Farmer L, Rollason R, Whitcomb D, Ni L, Goodliff A, Lay A, et al. TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. J Am Soc Nephrol. 2019;30:1910-1924 pubmed publisher |
Sherstyuk V, Davletshina G, Vyatkin Y, Shtokalo D, Vlasov V, Zakian S. A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Acta Naturae. 2019;11:92-97 pubmed publisher |
Hsieh M, Choe J, Gadhvi J, Kim Y, Arguez M, Palmer M, et al. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019;28:1860-1878.e9 pubmed publisher |
Hennessy E, van Solingen C, Scacalossi K, Ouimet M, Afonso M, Prins J, et al. The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nat Metab. 2019;1:98-110 pubmed publisher |
Chen J, Xiao Z, Meng X, Wang Y, Yu M, Huang W, et al. MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer. Theranostics. 2019;9:5049-5064 pubmed publisher |
Werner S, Lützkendorf J, Muller T, Müller L, Posern G. MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models. Sci Rep. 2019;9:11725 pubmed publisher |
Vera M, Tutucci E, Singer R. Imaging Single mRNA Molecules in Mammalian Cells Using an Optimized MS2-MCP System. Methods Mol Biol. 2019;2038:3-20 pubmed publisher |
Ishii S, Matsuura A, Itakura E. Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe. Sci Rep. 2019;9:11635 pubmed publisher |
Vennin C, Mélénec P, Rouet R, Nobis M, Cazet A, Murphy K, et al. CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nat Commun. 2019;10:3637 pubmed publisher |
Caiazza F, Oficjalska K, Tosetto M, Phelan J, Noonan S, Martin P, et al. KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment. Am J Pathol. 2019;189:1916-1932 pubmed publisher |
Park M, Wong M, Arauzo Bravo M, Lee H, Nam D, Park S, et al. Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model. PLoS ONE. 2019;14:e0221085 pubmed publisher |
El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, van Blerkom P, et al. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. 2019;178:1145-1158.e20 pubmed publisher |
Annunziata I, van de Vlekkert D, Wolf E, Finkelstein D, Neale G, Machado E, et al. MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat. Nat Commun. 2019;10:3623 pubmed publisher |
Sanghvi V, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, et al. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Cell. 2019;178:807-819.e21 pubmed publisher |
Knott G, Cress B, Liu J, Thornton B, Lew R, Al Shayeb B, et al. Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. elife. 2019;8: pubmed publisher |
Malone D, Lardelli R, Li M, David M. Dephosphorylation activates the interferon-stimulated schlafen family member 11 in the DNA Damage Response. J Biol Chem. 2019;: pubmed publisher |
Dalton W, Helmenstine E, Walsh N, Gondek L, Kelkar D, Read A, et al. Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. J Clin Invest. 2019;130:4708-4723 pubmed publisher |
Swain S, Grifka Walk H, Gripentrog J, Lehmann M, Deuling B, Jenkins B, et al. Slug and Snail have differential effects in directing colonic epithelial wound healing and partially mediate the restitutive effects of butyrate. Am J Physiol Gastrointest Liver Physiol. 2019;317:G531-G544 pubmed publisher |
Zhong Z, Sepramaniam S, Chew X, WOOD K, Lee M, Madan B, et al. PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. Oncogene. 2019;38:6662-6677 pubmed publisher |
James C, Prabhakar A, Otoa R, Evans M, Wang X, Bristol M, et al. SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes. mSphere. 2019;4: pubmed publisher |
Paul K, Darzi S, McPhee G, Del Borgo M, Werkmeister J, Gargett C, et al. 3D bioprinted endometrial stem cells on melt electrospun poly ε-caprolactone mesh for pelvic floor application promote anti-inflammatory responses in mice. Acta Biomater. 2019;97:162-176 pubmed publisher |
Butnaru M, Gaglia M. The Kaposi's Sarcoma-Associated Herpesvirus Protein ORF42 Is Required for Efficient Virion Production and Expression of Viral Proteins. Viruses. 2019;11: pubmed publisher |
Tews D, Pula T, Funcke J, Jastroch M, Keuper M, Debatin K, et al. Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes. Redox Biol. 2019;26:101286 pubmed publisher |
Pongjantarasatian S, Kadegasem P, Sasanakul W, Sa Ngiamsuntorn K, Borwornpinyo S, Sirachainan N, et al. Coagulant activity of recombinant human factor VII produced by lentiviral human F7 gene transfer in immortalized hepatocyte-like cell line. PLoS ONE. 2019;14:e0220825 pubmed publisher |
Guo D, Wang D, Liu C, Lu S, Hou Y, Zhang X. CRISPR-based genomic loci labeling revealed ordered spatial organization of chromatin in living diploid human cells. Biochim Biophys Acta Mol Cell Res. 2019;1866:118518 pubmed publisher |
Pringle E, Robinson C, McCormick C. Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. J Virol. 2019;93: pubmed publisher |
Gao F, Elliott N, Ho J, Sharp A, Shokhirev M, Hargreaves D. Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4. Mol Cell. 2019;75:891-904.e7 pubmed publisher |
Mears H, Emmott E, Chaudhry Y, Hosmillo M, Goodfellow I, Sweeney T. Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells. Wellcome Open Res. 2019;4:82 pubmed publisher |
Nishimura N, Radwan M, Amano M, Endo S, Fujii E, Hayashi H, et al. Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells. Cancer Sci. 2019;110:3275-3287 pubmed publisher |
Song M, Yang X, Ren X, Maliskova L, Li B, Jones I, et al. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Nat Genet. 2019;51:1252-1262 pubmed publisher |
Jiang C, Trudeau S, Cheong T, Guo R, Teng M, Wang L, et al. CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation. Cell Rep. 2019;28:1307-1322.e8 pubmed publisher |
Ji G, Liang H, Wang F, Wang N, Fu S, Cui X. TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer. Mol Cells. 2019;42:557-567 pubmed publisher |
Imajo M. Analysis of Retinoic Acid Receptor Signaling in Colorectal Cancer. Methods Mol Biol. 2019;2019:85-93 pubmed publisher |
Antao N, Marcet Ortega M, Cifani P, Kentsis A, Foley E. A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis. iScience. 2019;19:74-82 pubmed publisher |
Tammaro A, Scantlebery A, Rampanelli E, Borrelli C, Claessen N, Butter L, et al. TREM1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury and Mitochondrial Metabolic Flexibility in Tubular Epithelial Cells. Front Immunol. 2019;10:1469 pubmed publisher |
Vasavda C, Kothari R, Malla A, Tokhunts R, Lin A, Ji M, et al. Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide. Cell Chem Biol. 2019;26:1450-1460.e7 pubmed publisher |
Gulbranson D, Crisman L, Lee M, Ouyang Y, Menasche B, Demmitt B, et al. AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis. Dev Cell. 2019;50:436-446.e5 pubmed publisher |
Sheu Gruttadauria J, Pawlica P, Klum S, Wang S, Yario T, Schirle Oakdale N, et al. Structural Basis for Target-Directed MicroRNA Degradation. Mol Cell. 2019;75:1243-1255.e7 pubmed publisher |
Cai C, Wang X, Zhao Y, Yi C, Jin Z, Zhang A, et al. Construction of a mavs-inactivated MDCK cell line for facilitating the propagation of canine distemper virus (CDV). Mol Immunol. 2019;114:133-138 pubmed publisher |
Kim D, Camacho C, Nagari A, Malladi V, Challa S, Kraus W. Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21. Mol Cell. 2019;: pubmed publisher |
Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, et al. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nat Commun. 2019;10:3329 pubmed publisher |
Hollstein P, Eichner L, Brun S, Kamireddy A, Svensson R, Vera L, et al. The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC. Cancer Discov. 2019;9:1606-1627 pubmed publisher |
Logsdon G, Gambogi C, Liskovykh M, Barrey E, Larionov V, Miga K, et al. Human Artificial Chromosomes that Bypass Centromeric DNA. Cell. 2019;178:624-639.e19 pubmed publisher |
Wang R, Pscheid R, Ghumra A, Kan L, Cochrane S, Fairclough L, et al. Towards a surrogate system to express human lipid binding TCRs. Biotechnol Lett. 2019;41:1095-1104 pubmed publisher |
Elguindy M, Kopp F, Goodarzi M, Rehfeld F, Thomas A, Chang T, et al. PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD. elife. 2019;8: pubmed publisher |
Pertesi M, Ekdahl L, Palm A, Johnsson E, Järvstråt L, Wihlborg A, et al. Essential genes shape cancer genomes through linear limitation of homozygous deletions. Commun Biol. 2019;2:262 pubmed publisher |
Liu K, Jones S, Minis A, Rodriguez J, Molina H, Steller H. PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development. Dev Cell. 2019;50:509-524.e10 pubmed publisher |
Silva Evangelista C, Barret E, Ménez V, Merlevede J, Kergrohen T, Saccasyn A, et al. A kinome-wide shRNA screen uncovers vaccinia-related kinase 3 (VRK3) as an essential gene for diffuse intrinsic pontine glioma survival. Oncogene. 2019;38:6479-6490 pubmed publisher |
Wang L, Long H, Zheng Q, Bo X, Xiao X, Li B. Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. Mol Cancer. 2019;18:119 pubmed publisher |
Milenkovic V, Slim D, Bader S, Koch V, Heinl E, Alvarez Carbonell D, et al. CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Int J Mol Sci. 2019;20: pubmed publisher |
Bie F, Wang G, Qu X, Wang Y, Huang C, Wang Y, et al. Loss of FGL1 induces epithelial‑mesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma. Int J Oncol. 2019;55:697-707 pubmed publisher |
Moskovskich A, Goldmann U, Kartnig F, Lindinger S, Konecka J, Fiume G, et al. The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection. Sci Rep. 2019;9:10471 pubmed publisher |
Ye W, Han T, He M, Jan Y, Jan L. Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity. elife. 2019;8: pubmed publisher |
Liu J, Srinivasan S, Li C, Ho I, Rose J, Shaheen M, et al. Pooled library screening with multiplexed Cpf1 library. Nat Commun. 2019;10:3144 pubmed publisher |
Lin C, Lee C, Chuang Y, Lee J, Chiu Y, Wu Lee Y, et al. Membrane protein-regulated networks across human cancers. Nat Commun. 2019;10:3131 pubmed publisher |
Ye S, Ding Y, Jia W, Liu X, Feng J, Zhu Q, et al. SET Domain-Containing Protein 4 Epigenetically Controls Breast Cancer Stem Cell Quiescence. Cancer Res. 2019;79:4729-4743 pubmed publisher |
Povedano J, Liou J, Wei D, Srivatsav A, Kim J, Xie Y, et al. Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification. Cell Chem Biol. 2019;26:1315-1321.e3 pubmed publisher |
Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, et al. Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Cancer Cell. 2019;36:123-138.e10 pubmed publisher |
Vredevoogd D, Kuilman T, Ligtenberg M, Boshuizen J, Stecker K, de Bruijn B, et al. Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Cell. 2019;178:585-599.e15 pubmed publisher |
Bruntz R, Belshoff A, Zhang Y, Macedo J, Higashi R, Lane A, et al. Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer. Proteomics. 2019;19:e1800486 pubmed publisher |
Sun S, Kelekar S, Kliewer S, Mangelsdorf D. The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation. Genes Dev. 2019;33:1083-1094 pubmed publisher |
Petkau N, Budak H, Zhou X, Oster H, Eichele G. Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. elife. 2019;8: pubmed publisher |
Morley C, Ellison S, Bhattacharjee T, O Bryan C, Zhang Y, Smith K, et al. Quantitative characterization of 3D bioprinted structural elements under cell generated forces. Nat Commun. 2019;10:3029 pubmed publisher |
Zhang K, Lv D, Li R. Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication. Cell Rep. 2019;28:449-459.e5 pubmed publisher |
Woolston A, Khan K, Spain G, Barber L, Griffiths B, Gonzalez Exposito R, et al. Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. Cancer Cell. 2019;36:35-50.e9 pubmed publisher |
Chung C, Shin H, Berdan C, Ford B, Ward C, Olzmann J, et al. Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition. Nat Chem Biol. 2019;15:776-785 pubmed publisher |
Cui J, Zhang Q, Song Q, Wang H, Dmitriev P, Sun M, et al. Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma. Neuro Oncol. 2019;21:1436-1446 pubmed publisher |
Stone N, Gifford C, Thomas R, Pratt K, Samse Knapp K, Mohamed T, et al. Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming. Cell Stem Cell. 2019;25:87-102.e9 pubmed publisher |
Garanina E, Martynova E, Davidyuk Y, Kabwe E, Ivanov K, Titova A, et al. Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. Viruses. 2019;11: pubmed publisher |
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy A, et al. Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO J. 2019;38:e100926 pubmed publisher |
Hu T, Kitano A, Luu V, Dawson B, Hoegenauer K, Lee B, et al. Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche. Stem Cell Reports. 2019;: pubmed publisher |
Ge J, Remesh S, Hammel M, Pan S, Mahan A, Wang S, et al. Functional Relevance of Interleukin-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure. 2019;: pubmed publisher |
Wiel C, Le Gal K, Ibrahim M, Jahangir C, Kashif M, Yao H, et al. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell. 2019;: pubmed publisher |
Liu Z, Osipovitch M, Benraiss A, Huynh N, Foti R, Bates J, et al. Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling. Cell Rep. 2019;27:3832-3843.e6 pubmed publisher |
Zhou Y, Liu Z, Welch J, Gao X, Wang L, Garbutt T, et al. Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming. Cell Stem Cell. 2019;: pubmed publisher |
Mayank A, Pandey V, Vashisht A, Barshop W, Rayatpisheh S, Sharma T, et al. An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis. Mol Cell. 2019;: pubmed publisher |
Wang F, Chang C, Li R, Zhang Z, Jiang H, Zeng N, et al. Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Toxicology. 2019;: pubmed publisher |
Wang S, Chim B, Su Y, Khil P, Wong M, Wang X, et al. Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3. Genes Dev. 2019;: pubmed publisher |
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, et al. The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Cell Rep. 2019;27:3533-3546.e7 pubmed publisher |
Turturro S, Najor M, Yung T, Portt L, Malarkey C, Abukhdeir A, et al. Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway. Breast Cancer Res Treat. 2019;: pubmed publisher |
Chen P, Zhao D, Li J, Liang X, Li J, Chang A, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35:868-884.e6 pubmed publisher |
Min J, Wright W, Shay J. Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Genes Dev. 2019;33:814-827 pubmed publisher |
Headley K, Kedziora K, Alejo A, Lai E, Purvis J, Hathaway N. Chemical screen for epigenetic barriers to single allele activation of Oct4. Stem Cell Res. 2019;38:101470 pubmed publisher |
Wang W, Ishibashi J, Trefely S, Shao M, Cowan A, Sakers A, et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 2019;: pubmed publisher |
Wang T, Teo C, Akerblom M, Chen C, Tynan La Fontaine M, Greiner V, et al. Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area. Neuron. 2019;: pubmed publisher |
Tsutsumiuchi M, Hoshino H, Kogami A, Tsutsumiuchi T, Yokoyama O, Akama T, et al. Preferential expression of sialyl 6'-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes. Lab Invest. 2019;: pubmed publisher |
Weston S, Matthews K, Lent R, Vlk A, Haupt R, Kingsbury T, et al. A yeast suppressor screen used to identify mammalian SIRT1 as a proviral factor for MERS-CoV replication. J Virol. 2019;: pubmed publisher |
Freije A, Sanz Gómez N, Gandarillas A. Genetic Modification of Human Primary Keratinocytes by Lentiviral Vectors. Methods Mol Biol. 2019;: pubmed publisher |
He L, Zhou J, Chen M, Lin C, Kim S, Zhou Y, et al. Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix. Nat Mater. 2019;18:627-637 pubmed publisher |
Davis C, Jackson K, McElroy A, Halfmann P, Huang J, Chennareddy C, et al. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Cell. 2019;: pubmed publisher |
Zhao X, Ren Y, Lawlor M, Shah B, Park P, Lwin T, et al. BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 2019;35:752-766.e9 pubmed publisher |
Hickey S, Berto S, Konopka G. Chromatin Decondensation by FOXP2 Promotes Human Neuron Maturation and Expression of Neurodevelopmental Disease Genes. Cell Rep. 2019;27:1699-1711.e9 pubmed publisher |
Sobh A, Loguinov A, Stornetta A, Balbo S, Tagmount A, Zhang L, et al. Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde. Toxicol Sci. 2019;169:235-245 pubmed publisher |
Mitchell D, Menon A, Garner A. Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Cell Chem Biol. 2019;: pubmed publisher |
Ishizawa J, Zarabi S, Davis R, Halgas O, Nii T, Jitkova Y, et al. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell. 2019;35:721-737.e9 pubmed publisher |
Ghosh M, Lo R, Ivic I, Aguilera B, Qendro V, Devarakonda C, et al. CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration. Sci Signal. 2019;12: pubmed publisher |
Yan C, Brunson D, Tang Q, Do D, Iftimia N, Moore J, et al. Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish. Cell. 2019;: pubmed publisher |
Ast T, Meisel J, Patra S, Wang H, Grange R, Kim S, et al. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;: pubmed publisher |
Lalioti M, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, et al. GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73. J Cell Sci. 2019;132: pubmed publisher |
Nakanishi M, Mitchell R, Benoit Y, Orlando L, Reid J, Shimada K, et al. Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Cell. 2019;177:910-924.e22 pubmed publisher |
Herwig J, Skuza S, Sachs W, Sachs M, Failla A, Rune G, et al. Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. J Am Soc Nephrol. 2019;30:824-839 pubmed publisher |
Mair B, Tomic J, Masud S, Tonge P, Weiss A, Usaj M, et al. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies. Cell Rep. 2019;27:599-615.e12 pubmed publisher |
Jung J, Macalino S, Cui M, Kim J, Kim H, Song D, et al. Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Cell Metab. 2019;29:1306-1319.e7 pubmed publisher |
Zhao P, Wang P, Dong S, Zhou Z, Cao Y, Yagita H, et al. Depletion of PD-1-positive cells ameliorates autoimmune disease. Nat Biomed Eng. 2019;3:292-305 pubmed publisher |
Valverde D, Yu S, Boggavarapu V, Kumar N, Lees J, Walz T, et al. ATG2 transports lipids to promote autophagosome biogenesis. J Cell Biol. 2019;218:1787-1798 pubmed publisher |
Varum S, Baggiolini A, Zurkirchen L, Atak Z, Cantù C, Marzorati E, et al. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019;24:637-653.e9 pubmed publisher |
Morton E, Forst C, Zheng Y, DePaula Silva A, Ramirez N, Planelles V, et al. Transcriptional Circuit Fragility Influences HIV Proviral Fate. Cell Rep. 2019;27:154-171.e9 pubmed publisher |
He M, Huang T, Li S, Hong H, Chen Z, Martin M, et al. Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Arterioscler Thromb Vasc Biol. 2019;39:902-914 pubmed publisher |
Li H, Petersen S, García Mariscal A, Brakebusch C. Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation. Cancer Res. 2019;79:2167-2181 pubmed publisher |
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed publisher |
Kailayangiri S, Altvater B, Lesch S, Balbach S, Göttlich C, Kühnemundt J, et al. EZH2 Inhibition in Ewing Sarcoma Upregulates GD2 Expression for Targeting with Gene-Modified T Cells. Mol Ther. 2019;27:933-946 pubmed publisher |
Short S, Barrett C, Stengel K, Revetta F, Choksi Y, Coburn L, et al. Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Oncogene. 2019;38:5091-5106 pubmed publisher |
Fiedler L, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush P, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019;24:579-591.e12 pubmed publisher |
Tan Y, Kagan J. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019;: pubmed publisher |
Piya S, Mu H, Bhattacharya S, Lorenzi P, Davis R, McQueen T, et al. BETP degradation simultaneously targets acute myelogenous leukemia stem cells and the microenvironment. J Clin Invest. 2019;130: pubmed publisher |
Barnett K, Coronas Serna J, Zhou W, Ernandes M, Cao A, Kranzusch P, et al. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019;: pubmed publisher |
Sobh A, Loguinov A, Yazici G, Zeidan R, Tagmount A, Hejazi N, et al. Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity. Toxicol Sci. 2019;169:108-121 pubmed publisher |
Tchieu J, Calder E, GUTTIKONDA S, Gutzwiller E, Aromolaran K, Steinbeck J, et al. NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells. Nat Biotechnol. 2019;37:267-275 pubmed publisher |
Harris I, Endress J, Coloff J, Selfors L, McBrayer S, Rosenbluth J, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019;29:1166-1181.e6 pubmed publisher |
Wang E, Lu S, Pastore A, Chen X, Imig J, Chun Wei Lee S, et al. Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Cancer Cell. 2019;35:369-384.e7 pubmed publisher |
Van Loo K, Rummel C, Pitsch J, Müller J, Bikbaev A, Martínez Chávez E, et al. Calcium Channel Subunit α2δ4 Is Regulated by Early Growth Response 1 and Facilitates Epileptogenesis. J Neurosci. 2019;39:3175-3187 pubmed publisher |
Sen P, Lan Y, Li C, Sidoli S, Donahue G, Dou Z, et al. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019;73:684-698.e8 pubmed publisher |
Nehls J, Businger R, Hoffmann M, Brinkmann C, Fehrenbacher B, Schaller M, et al. Release of Immunomodulatory Ebola Virus Glycoprotein-Containing Microvesicles Is Suppressed by Tetherin in a Species-Specific Manner. Cell Rep. 2019;26:1841-1853.e6 pubmed publisher |
Tao Y, Kang B, Petkovich D, Bhandari Y, In J, Stein O Brien G, et al. Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced Tumorigenesis. Cancer Cell. 2019;35:315-328.e6 pubmed publisher |
Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher |
Bajc Česnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, et al. Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. J Cell Sci. 2019;132: pubmed publisher |
Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, et al. Widespread and Functional RNA Circularization in Localized Prostate Cancer. Cell. 2019;176:831-843.e22 pubmed publisher |
Augert A, Eastwood E, Ibrahim A, Wu N, Grunblatt E, Basom R, et al. Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Sci Signal. 2019;12: pubmed publisher |
Sastre Perona A, Hoang Phou S, Leitner M, Okuniewska M, Meehan S, Schober M. De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Cell Stem Cell. 2019;24:390-404.e8 pubmed publisher |
Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019;176:1113-1127.e16 pubmed publisher |
Kim J, Yu L, Chen W, Xu Y, Wu M, Todorova D, et al. Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation. Cancer Cell. 2019;35:191-203.e8 pubmed publisher |
Yadav D, Ghosh K, Basu S, Roeder R, Biswas D. Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control. Cell Rep. 2019;26:1303-1317.e7 pubmed publisher |
Wang Z, Sheng C, Yao C, Chen H, Wang D, Chen S. The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization. Cell Rep. 2019;26:1273-1285.e5 pubmed publisher |
Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, et al. Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Cancer Cell. 2019;35:177-190.e8 pubmed publisher |
Qian Y, Piatkevich K, Mc Larney B, Abdelfattah A, Mehta S, Murdock M, et al. A genetically encoded near-infrared fluorescent calcium ion indicator. Nat Methods. 2019;16:171-174 pubmed publisher |
Zhang H, Savage S, Schultz A, Bottomly D, White L, Segerdell E, et al. Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Nat Commun. 2019;10:244 pubmed publisher |
Lin C, Zhang Y, Zhang K, Zheng Y, Lu L, Chang H, et al. Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity. 2019;50:137-151.e6 pubmed publisher |
Paschos K, Bazot Q, Lees J, Farrell P, Allday M. Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C. Nucleic Acids Res. 2019;47:2807-2821 pubmed publisher |
Mendoza Rodríguez M, Ayala Sumuano J, Garcia Morales L, Zamudio Meza H, Pérez Yépez E, Meza I. IL-1β Inflammatory Cytokine-Induced TP63 Isoform ∆NP63α Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher |
Yuan F, Liu B, Xu Y, Li Y, Sun Q, Xu P, et al. TIPE3 is a regulator of cell apoptosis in glioblastoma. Cancer Lett. 2019;446:1-14 pubmed publisher |
Gu T, Yu D, Li Y, Xu L, Yao Y, Yao Y. Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). Appl Microbiol Biotechnol. 2019;103:2171-2180 pubmed publisher |
Oakes B, Fellmann C, Rishi H, Taylor K, Ren S, Nadler D, et al. CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification. Cell. 2019;176:254-267.e16 pubmed publisher |
Hemming M, Lawlor M, Andersen J, Hagan T, Chipashvili O, Scott T, et al. Enhancer Domains in Gastrointestinal Stromal Tumor Regulate KIT Expression and Are Targetable by BET Bromodomain Inhibition. Cancer Res. 2019;79:994-1009 pubmed publisher |
Boyd N, Walker K, Ayokanmbi A, Gordon E, Whetsel J, Smith C, et al. Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis. Stem Cells. 2019;37:453-462 pubmed publisher |
Taylor A, Sharkey J, Plagge A, Wilm B, Murray P. Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc-Based BRET Reporter in Combination with Firefly Luciferase. Contrast Media Mol Imaging. 2018;2018:2514796 pubmed publisher |
Han T, Ye W, Bethel N, Zubia M, Kim A, Li K, et al. Chemically induced vesiculation as a platform for studying TMEM16F activity. Proc Natl Acad Sci U S A. 2019;116:1309-1318 pubmed publisher |
Liu S, Hausmann S, CARLSON S, Fuentes M, Francis J, Pillai R, et al. METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis. Cell. 2019;176:491-504.e21 pubmed publisher |
Chen M, Lo Y, Chen X, Williams C, Donnelly J, Criss Z, et al. Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer. Mol Cancer Res. 2019;17:697-708 pubmed publisher |
Wang J, Hao J, Wang X, Guo H, Sun H, Lai X, et al. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep. 2019;26:209-221.e5 pubmed publisher |
Yang X, Hu Z, Zhang Q, Fan S, Zhong Y, Guo D, et al. SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists. Cell Discov. 2019;5:1 pubmed publisher |
Zhu T, Tian D, Zhang L, Xu X, Xia K, Hu Z, et al. Novel mutations in mevalonate kinase cause disseminated superficial actinic porokeratosis. Br J Dermatol. 2018;: pubmed publisher |
Luedtke D, Su Y, Liu S, Edwards H, Wang Y, Lin H, et al. Inhibition of XPO1 enhances cell death induced by ABT-199 in acute myeloid leukaemia via Mcl-1. J Cell Mol Med. 2018;22:6099-6111 pubmed publisher |
Yost S, Whidby J, Khan A, Wang Y, Marcotrigiano J. Overcoming Challenges of Hepatitis C Virus Envelope Glycoprotein Production in Mammalian Cells. Methods Mol Biol. 2019;1911:305-316 pubmed publisher |
Ciolli Mattioli C, Rom A, Franke V, Imami K, Arrey G, Terne M, et al. Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments. Nucleic Acids Res. 2019;47:2560-2573 pubmed publisher |
Haldeman J, Conway A, Arlotto M, Slentz D, Muoio D, Becker T, et al. Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing. Nucleic Acids Res. 2019;47:e23 pubmed publisher |
Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea Rodríguez I, et al. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Cell Rep. 2018;25:3674-3692.e10 pubmed publisher |
Piroli G, Manuel A, Patel T, Walla M, Shi L, Lanci S, et al. Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization. Mol Cell Proteomics. 2019;18:504-519 pubmed publisher |
Lee J, Kim S, Song J, Lee Y, Ko H. Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation. Osong Public Health Res Perspect. 2018;9:334-339 pubmed publisher |
Yang F, Takagaki Y, Yoshitomi Y, Ikeda T, Li J, Kitada M, et al. Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial-Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis. Cancer Res. 2019;79:735-746 pubmed publisher |
Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song C, et al. A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Mol Cell. 2019;73:714-726.e4 pubmed publisher |
Leto D, Morgens D, Zhang L, Walczak C, Elias J, Bassik M, et al. Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Mol Cell. 2019;73:377-389.e11 pubmed publisher |
Thier M, Hommerding O, Panten J, Pinna R, García González D, Berger T, et al. Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells. Cell Stem Cell. 2019;24:166-182.e13 pubmed publisher |
Tiemann K, Garri C, Lee S, Malihi P, Park M, Alvarez R, et al. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Oncogene. 2019;38:3003-3018 pubmed publisher |
Sanson K, Hanna R, Hegde M, Donovan K, Strand C, Sullender M, et al. Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities. Nat Commun. 2018;9:5416 pubmed publisher |
Mon E, Wei F, Ahmad R, Yamamoto T, Moroishi T, Tomizawa K. Regulation of mitochondrial iron homeostasis by sideroflexin 2. J Physiol Sci. 2019;69:359-373 pubmed publisher |
Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, et al. High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer. Int J Oncol. 2019;54:479-490 pubmed publisher |
Oladimeji P, Wright W, Wu J, Chen T. RNA interference screen identifies NAA10 as a regulator of PXR transcription. Biochem Pharmacol. 2019;160:92-109 pubmed publisher |
Xu Y, Zhang Q, Miao C, Dongol S, Li Y, Jin C, et al. CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression. Cancer Med. 2018;: pubmed publisher |
Quinton R, Ganem N. CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Methods Mol Biol. 2019;1893:203-214 pubmed publisher |
Wang J, Xu S, Duan J, Yi L, Guo Y, Shi Y, et al. Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Nat Neurosci. 2019;22:91-105 pubmed publisher |
Breinig M, Schweitzer A, Herianto A, Revia S, Schaefer L, Wendler L, et al. Multiplexed orthogonal genome editing and transcriptional activation by Cas12a. Nat Methods. 2019;16:51-54 pubmed publisher |
Xu X, Hirata H, Shiraki M, Kamohara A, Nishioka K, Miyamoto H, et al. Prostate transmembrane protein androgen induced 1 is induced by activation of osteoclasts and regulates bone resorption. FASEB J. 2019;33:4365-4375 pubmed publisher |
Zhang Z, Chen J, Huang W, Ning D, Liu Q, Wang C, et al. FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma. Mol Oncol. 2019;13:792-810 pubmed publisher |
Wörthmüller J, Blum W, Pecze L, Salicio V, Schwaller B. Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway. Oncotarget. 2018;9:36256-36272 pubmed publisher |
Goyal R, Kapadia C, Melamed J, Riley R, Day E. Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a. Cell Mol Bioeng. 2018;11:383-396 pubmed publisher |
Narayana Y, Gadgil C, Mote R, Rajan R, Subramanyam D. Clathrin-Mediated Endocytosis Regulates a Balance between Opposing Signals to Maintain the Pluripotent State of Embryonic Stem Cells. Stem Cell Reports. 2019;12:152-164 pubmed publisher |
Signes A, Cerutti R, Dickson A, Benincá C, Hinchy E, Ghezzi D, et al. APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. EMBO Mol Med. 2019;11: pubmed publisher |
Nakanishi Y, Duran A, L Hermitte A, Shelton P, Nakanishi N, Reina Campos M, et al. Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Immunity. 2018;49:1132-1147.e7 pubmed publisher |
Kaneko N, Herranz Pérez V, Otsuka T, Sano H, Ohno N, Omata T, et al. New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration. Sci Adv. 2018;4:eaav0618 pubmed publisher |
Tan J, Gleeson P. The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neurons. J Biol Chem. 2019;294:1618-1631 pubmed publisher |
Wörthmüller J, Oberson A, Salicio V, Blum W, Schwaller B. Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca2+-Binding Proteins Calbindin-D28k and Parvalbumin. Int J Mol Sci. 2018;19: pubmed publisher |
Harirchian P, Lee J, Hilz S, Sedgewick A, Perez White B, Kesling M, et al. A20 and ABIN1 Suppression of a Keratinocyte Inflammatory Program with a Shared Single-Cell Expression Signature in Diverse Human Rashes. J Invest Dermatol. 2019;139:1264-1273 pubmed publisher |
Trobridge G. Mutagenesis Screens for Prostate Cancer Using Replication-Incompetent Lentiviral Vectors. Methods Mol Biol. 2019;1907:103-114 pubmed publisher |
Li Q, Chen D, Xiang Q, Nicholas J. Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication. J Virol. 2019;93: pubmed publisher |
Neviani P, Wise P, Murtadha M, Liu C, Wu C, Jong A, et al. Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms. Cancer Res. 2019;79:1151-1164 pubmed publisher |
Xiong X, Schober M, Tassone E, Khodadadi Jamayran A, Sastre Perona A, Zhou H, et al. KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer. Cell Rep. 2018;25:3006-3020.e7 pubmed publisher |
Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson N, Gleeson P. Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture. Mol Biol Cell. 2019;30:370-386 pubmed publisher |
He B, Deng T, Zhu I, Furusawa T, Zhang S, Tang W, et al. Binding of HMGN proteins to cell specific enhancers stabilizes cell identity. Nat Commun. 2018;9:5240 pubmed publisher |
Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, et al. Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. EMBO J. 2019;38: pubmed publisher |
Cai Z, Kotzin J, Ramdas B, Chen S, Nelanuthala S, Palam L, et al. Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis. Cell Stem Cell. 2018;23:833-849.e5 pubmed publisher |
Kowalczyk Quintas C, Chevalley D, Willen L, Jandus C, Vigolo M, Schneider P. Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab. Front Immunol. 2018;9:2698 pubmed publisher |
Knuth A, Rösler S, Schenk B, Kowald L, van Wijk S, Fulda S. Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells. Neoplasia. 2019;21:74-81 pubmed publisher |
OhAinle M, Helms L, Vermeire J, Roesch F, Humes D, Basom R, et al. A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. elife. 2018;7: pubmed publisher |
Han T, Nijhawan D. Exome Sequencing of Drug-Resistant Clones for Target Identification. Methods Mol Biol. 2019;1888:175-187 pubmed publisher |
Timms R, Tchasovnikarova I, Lehner P. Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites. Nat Protoc. 2019;14:153-170 pubmed publisher |
Bainor A, Saini S, Calderon A, Casado Polanco R, Giner Ramirez B, Moncada C, et al. The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Cell Rep. 2018;25:2797-2807.e8 pubmed publisher |
McClurg U, McCracken S, Butler L, Riabowol K, Binda O. Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. Bio Protoc. 2018;8: pubmed publisher |
Seeholzer T, Kurz S, Schlauderer F, Woods S, Gehring T, Widmann S, et al. BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation. Front Immunol. 2018;9:2695 pubmed publisher |
Briard B, Karki R, Malireddi R, Bhattacharya A, Place D, Mavuluri J, et al. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nat Microbiol. 2019;4:316-327 pubmed publisher |
Shi Z, Tchernichovski O, Li X. Studying the Mechanisms of Developmental Vocal Learning and Adult Vocal Performance in Zebra Finches through Lentiviral Injection. Bio Protoc. 2017;8: pubmed publisher |
Lu B, Klingbeil O, Tarumoto Y, Somerville T, Huang Y, Wei Y, et al. A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence. Cancer Cell. 2018;34:970-981.e8 pubmed publisher |
Ott C, Federation A, Schwartz L, Kasar S, Klitgaard J, Lenci R, et al. Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia. Cancer Cell. 2018;34:982-995.e7 pubmed publisher |
Debaize L, Jakobczyk H, Avner S, Gaudichon J, Rio A, Sérandour A, et al. Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Nucleic Acids Res. 2018;46:11214-11228 pubmed publisher |
Paul D, Bargale A, Rapole S, Shetty P, Santra M. Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway. Neoplasia. 2019;21:30-40 pubmed publisher |
Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, et al. Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Nat Commun. 2018;9:5058 pubmed publisher |
Lee S, Cieply B, Yang Y, Peart N, Glaser C, Chan P, et al. Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity. Cell Rep. 2018;25:2417-2430.e5 pubmed publisher |
Nejati Moharrami N, Bjørkøy Tande E, Ryan L, Espevik T, Boyartchuk V. RORα controls inflammatory state of human macrophages. PLoS ONE. 2018;13:e0207374 pubmed publisher |
Shihabudeen Haider Ali M, Cheng X, Moran M, Haemmig S, Naldrett M, Alvarez S, et al. LncRNA Meg3 protects endothelial function by regulating the DNA damage response. Nucleic Acids Res. 2019;47:1505-1522 pubmed publisher |
Unni A, Harbourne B, Oh M, Wild S, Ferrarone J, Lockwood W, et al. Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells. elife. 2018;7: pubmed publisher |
Bariana T, Labarque V, Heremans J, Thys C, De Reys M, Greene D, et al. Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia. Haematologica. 2019;104:1036-1045 pubmed publisher |
Prasad R, Horton J, Dai D, Wilson S. Repair pathway for PARP-1 DNA-protein crosslinks. DNA Repair (Amst). 2019;73:71-77 pubmed publisher |
Jangra R, Herbert A, Li R, Jae L, Kleinfelter L, Slough M, et al. Protocadherin-1 is essential for cell entry by New World hantaviruses. Nature. 2018;563:559-563 pubmed publisher |
Updegraff B, Zhou X, Guo Y, Padanad M, Chen P, Yang C, et al. Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Cell Rep. 2018;25:2223-2233.e6 pubmed publisher |
Kubala M, Punj V, Placencio Hickok V, Fang H, Fernandez G, Sposto R, et al. Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Cell Rep. 2018;25:2177-2191.e7 pubmed publisher |
Kim C, Hu B, Jadhav R, Jin J, Zhang H, Cavanagh M, et al. Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells. Cell Rep. 2018;25:2148-2162.e5 pubmed publisher |
Daviaud N, Friedel R, Zou H. Vascularization and Engraftment of Transplanted Human Cerebral Organoids in Mouse Cortex. Eneuro. 2018;5: pubmed publisher |
Arnandis T, Monteiro P, Adams S, Bridgeman V, Rajeeve V, Gadaleta E, et al. Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Dev Cell. 2018;47:409-424.e9 pubmed publisher |
Elegheert J, Behiels E, Bishop B, Scott S, Woolley R, Griffiths S, et al. Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins. Nat Protoc. 2018;13:2991-3017 pubmed publisher |
Rothenberg K, Puranam I, Hoffman B. Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques. J Vis Exp. 2018;: pubmed publisher |
Preussner J, Zhong J, Sreenivasan K, Günther S, Engleitner T, Künne C, et al. Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype. Cell Stem Cell. 2018;23:794-805.e4 pubmed publisher |
Shifrut E, Carnevale J, Tobin V, Roth T, Woo J, Bui C, et al. Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Cell. 2018;175:1958-1971.e15 pubmed publisher |
Larabee J, Hauck G, Ballard J. Unique, Intersecting, and Overlapping Roles of C/EBP β and CREB in Cells of the Innate Immune System. Sci Rep. 2018;8:16931 pubmed publisher |
Sharif T, Martell E, Dai C, Ghassemi Rad M, Hanes M, Murphy P, et al. HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. Autophagy. 2018;: pubmed publisher |
Brien G, Remillard D, Shi J, Hemming M, Chabon J, Wynne K, et al. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. elife. 2018;7: pubmed publisher |
Somerville T, Xu Y, Miyabayashi K, Tiriac H, Cleary C, Maia Silva D, et al. TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. Cell Rep. 2018;25:1741-1755.e7 pubmed publisher |
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, et al. PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis. Apoptosis. 2019;24:135-144 pubmed publisher |
Dias M, Fonseca C, Zeidler J, Albuquerque L, Da Silva M, Cararo Lopes E, et al. Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors. Mol Oncol. 2019;13:290-306 pubmed publisher |
Bae Y, Joo H, Bae J, Hyeon S, Her S, Ko E, et al. Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell Death Dis. 2018;9:1125 pubmed publisher |
Villar Prados A, Wu S, Court K, Ma S, LaFargue C, Chowdhury M, et al. Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4. Mol Cancer Ther. 2019;18:421-436 pubmed publisher |
Feng M, Xiong G, Cao Z, Yang G, Zheng S, Qiu J, et al. LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer. J Exp Clin Cancer Res. 2018;37:274 pubmed publisher |
Yu L, Wang L, Mao C, Duraki D, Kim J, Huang R, et al. Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations. Cancer Lett. 2019;442:373-382 pubmed publisher |
Merindol N, El Far M, Sylla M, Masroori N, Dufour C, Li J, et al. HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state. PLoS Pathog. 2018;14:e1007398 pubmed publisher |
Eisemann T, Costa B, Harter P, Wick W, Mittelbronn M, Angel P, et al. Podoplanin expression is a prognostic biomarker but may be dispensable for the malignancy of glioblastoma. Neuro Oncol. 2019;21:326-336 pubmed publisher |
Müller M, Fouyssac M, Taylor C. Effective Glucose Uptake by Human Astrocytes Requires Its Sequestration in the Endoplasmic Reticulum by Glucose-6-Phosphatase-β. Curr Biol. 2018;28:3481-3486.e4 pubmed publisher |
Goodspeed A, Jean A, Costello J. A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer. Eur Urol. 2019;75:242-250 pubmed publisher |
Tan P, Ye Y, He L, Xie J, Jing J, Ma G, et al. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biol. 2018;16:e3000051 pubmed publisher |
Rodriguez Gutierrez D, Eid W, Biason Lauber A. A Human Gonadal Cell Model From Induced Pluripotent Stem Cells. Front Genet. 2018;9:498 pubmed publisher |
Shakya S, Sharma P, Bhatt A, Jani R, Delevoye C, Setty S. Rab22A recruits BLOC-1 and BLOC-2 to promote the biogenesis of recycling endosomes. EMBO Rep. 2018;19: pubmed publisher |
Merwaiss F, Czibener C, Alvarez D. Cell-to-Cell Transmission Is the Main Mechanism Supporting Bovine Viral Diarrhea Virus Spread in Cell Culture. J Virol. 2019;93: pubmed publisher |
Platnich J, Chung H, Lau A, Sandall C, Bondzi Simpson A, Chen H, et al. Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Rep. 2018;25:1525-1536.e7 pubmed publisher |
Suryawanshi H, Morozov P, Straus A, Sahasrabudhe N, Max K, Garzia A, et al. A single-cell survey of the human first-trimester placenta and decidua. Sci Adv. 2018;4:eaau4788 pubmed publisher |
Leoz M, Kukanja P, Luo Z, Huang F, Cary D, Peterlin B, et al. HEXIM1-Tat chimera inhibits HIV-1 replication. PLoS Pathog. 2018;14:e1007402 pubmed publisher |
Hulse M, Caruso L, Madzo J, Tan Y, Johnson S, Tempera I. Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1. PLoS Pathog. 2018;14:e1007394 pubmed publisher |
Riestra A, Valderrama J, Patras K, Booth S, Quek X, Tsai C, et al. Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages. J Innate Immun. 2019;11:86-98 pubmed publisher |
Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y, et al. Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Cancer Lett. 2018;442:53-67 pubmed publisher |
Sade Feldman M, Yizhak K, Bjorgaard S, Ray J, de Boer C, Jenkins R, et al. Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma. Cell. 2018;175:998-1013.e20 pubmed publisher |
Song J, Yuan C, Yang J, Liu T, Yao Y, Xiao X, et al. Novel flavagline-like compounds with potent Fli-1 inhibitory activity suppress diverse types of leukemia. FEBS J. 2018;285:4631-4645 pubmed publisher |
Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Nat Commun. 2018;9:4545 pubmed publisher |
Polak R, Bierings M, van der Leije C, Sanders M, Roovers O, Marchante J, et al. Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia. Haematologica. 2019;104:738-748 pubmed publisher |
Neumeyer V, Grandl M, Dietl A, Brutau Abia A, Allgäuer M, Kalali B, et al. Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells. Carcinogenesis. 2019;40:551-559 pubmed publisher |
Singh K, Han K, Tilve S, Wu K, Geller H, Sack M. Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation. Glia. 2018;66:2427-2437 pubmed publisher |
Song S, Zhang R, Cao W, Fang G, Yu Y, Wan Y, et al. Foxm1 is a critical driver of TGF-β-induced EndMT in endothelial cells through Smad2/3 and binds to the Snail promoter. J Cell Physiol. 2019;234:9052-9064 pubmed publisher |
Xian X, Pohlkamp T, Durakoglugil M, Wong C, Beck J, Lane Donovan C, et al. Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer's disease. elife. 2018;7: pubmed publisher |
Oser M, Fonseca R, Chakraborty A, Brough R, Spektor A, Jennings R, et al. Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. Cancer Discov. 2019;9:230-247 pubmed publisher |
Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, et al. A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun. 2018;9:4475 pubmed publisher |
Luong P, Hedl M, Yan J, Zuo T, Fu T, Jiang X, et al. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. elife. 2018;7: pubmed publisher |
Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, et al. Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Nat Commun. 2018;9:4385 pubmed publisher |
Norambuena A, Wallrabe H, Cao R, Wang D, Silva A, Švindrych Z, et al. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. EMBO J. 2018;37: pubmed publisher |
Batool S, Argyropoulos K, Azad R, Okeoma P, Zumrut H, Bhandari S, et al. Dimerization of an aptamer generated from Ligand-guided selection (LIGS) yields a high affinity scaffold against B-cells. Biochim Biophys Acta Gen Subj. 2019;1863:232-240 pubmed publisher |
Heo H, Jo J, Jung J, Han Y, Lee S, Kim S, et al. Improved dynamic monitoring of transcriptional activity during longitudinal analysis in the mouse brain. Biol Open. 2019;8: pubmed publisher |
Shrimali P, Peter M, Singh A, Dalal N, Dakave S, Chiplunkar S, et al. Efficient in situ gene delivery via PEG diacrylate matrices. Biomater Sci. 2018;6:3241-3250 pubmed publisher |
Kim H, Kim D, Bae S, Gwak H, Jeon J, Kim J, et al. Farnesyl diphosphate synthase is important for the maintenance of glioblastoma stemness. Exp Mol Med. 2018;50:137 pubmed publisher |
Clark C, Maile M, Blaney P, Hellweg S, Strauss A, Durose W, et al. Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene. Sci Rep. 2018;8:15327 pubmed publisher |
Cai M, Li S, Shuai Y, Li J, Tan J, Zeng Q. Genome-wide CRISPR-Cas9 viability screen reveals genes involved in TNF-α-induced apoptosis of human umbilical vein endothelial cells. J Cell Physiol. 2019;234:9184-9193 pubmed publisher |
Martín Peña A, Porter R, Plumton G, McCarrel T, Morton A, Guijarro M, et al. Lentiviral-based reporter constructs for profiling chondrogenic activity in primary equine cell populations. Eur Cell Mater. 2018;36:156-170 pubmed publisher |
Paul S, Ghosh S, Mandal S, Sau S, Pal M. NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018;293:19303-19316 pubmed publisher |
Castañeda A, Glaunsinger B. The Interaction between ORF18 and ORF30 Is Required for Late Gene Expression in Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2019;93: pubmed publisher |
von Kleist L, Ariunbat K, Braren I, Stauber T, Storch S, Danyukova T. A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival. Mol Genet Metab. 2019;126:196-205 pubmed publisher |
Tu W, Shiah Y, Lourenco C, Mullen P, Dingar D, Redel C, et al. MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis. Cancer Cell. 2018;34:579-595.e8 pubmed publisher |
Villiger L, Grisch Chan H, Lindsay H, Ringnalda F, Pogliano C, Allegri G, et al. Treatment of a metabolic liver disease by in vivo genome base editing in adult mice. Nat Med. 2018;24:1519-1525 pubmed publisher |
Chiarella A, Wang T, Butler K, Jin J, Hathaway N. Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers. J Vis Exp. 2018;: pubmed publisher |
McNamara H, Dodson S, Huang Y, Miller E, Sandstede B, Cohen A. Geometry-Dependent Arrhythmias in Electrically Excitable Tissues. Cell Syst. 2018;7:359-370.e6 pubmed publisher |
Axelrod H, Valkenburg K, Amend S, Hicks J, Parsana P, Torga G, et al. AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer. Mol Cancer Res. 2019;17:356-369 pubmed publisher |
Cheruiyot A, Li S, Nickless A, Roth R, Fitzpatrick J, You Z. Compound C inhibits nonsense-mediated RNA decay independently of AMPK. PLoS ONE. 2018;13:e0204978 pubmed publisher |
Ungerleider N, Rao S, Shahbandi A, Yee D, Niu T, Frey W, et al. Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. Breast Cancer Res. 2018;20:115 pubmed publisher |
Bradley T, Ferrari G, Haynes B, Margolis D, Browne E. Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency. Cell Rep. 2018;25:107-117.e3 pubmed publisher |
Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner K, et al. Molecular architecture and regulation of BCL10-MALT1 filaments. Nat Commun. 2018;9:4041 pubmed publisher |
Fan L, Nehme R, Adam Y, Jung E, Wu H, Eggan K, et al. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 2018;15:823-831 pubmed publisher |
Tome Garcia J, Erfani P, Nudelman G, Tsankov A, Katsyv I, Tejero R, et al. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Nat Commun. 2018;9:4020 pubmed publisher |
Kami D, Kitani T, Nakamura A, Wakui N, Mizutani R, Ohue M, et al. The DEAD-box RNA-binding protein DDX6 regulates parental RNA decay for cellular reprogramming to pluripotency. PLoS ONE. 2018;13:e0203708 pubmed publisher |
Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, et al. Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell. 2018;34:659-673.e6 pubmed publisher |
Bradley T, Peppa D, Pedroza Pacheco I, Li D, Cain D, Henao R, et al. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Cell. 2018;175:387-399.e17 pubmed publisher |
Kantor B, Tagliafierro L, Gu J, Zamora M, Ilich E, Grenier C, et al. Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD. Mol Ther. 2018;26:2638-2649 pubmed publisher |
Hepler C, Shan B, Zhang Q, Henry G, Shao M, Vishvanath L, et al. Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. elife. 2018;7: pubmed publisher |
Parker S, Moutal A, Cai S, Chandrasekaran S, Roman M, Koshy A, et al. High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons. Eneuro. 2018;5: pubmed publisher |
Shu T, Song X, Cui X, Ge W, Gao R, Wang J. Fc Gamma Receptor IIb Expressed in Hepatocytes Promotes Lipid Accumulation and Gluconeogenesis. Int J Mol Sci. 2018;19: pubmed publisher |
Ren Y, Bi C, Zhao X, Lwin T, Wang C, Yuan J, et al. PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas. J Clin Invest. 2018;128:5517-5530 pubmed publisher |
Nacson J, Krais J, Bernhardy A, Clausen E, Feng W, Wang Y, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Rep. 2018;24:3513-3527.e7 pubmed publisher |
Li W, Yu X, Xia Z, Yu X, Xie L, Ma X, et al. Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells. J Cell Mol Med. 2018;22:6213-6227 pubmed publisher |
Emmer B, Hesketh G, Kotnik E, Tang V, Lascuna P, Xiang J, et al. The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. elife. 2018;7: pubmed publisher |
Zhou C, Zhang L, Xu P. Growth inhibition and chemo-radiosensitization of esophageal squamous cell carcinoma by survivin-shRNA lentivirus transfection. Oncol Lett. 2018;16:4813-4820 pubmed publisher |
Clift D, So C, McEwan W, James L, Schuh M. Acute and rapid degradation of endogenous proteins by Trim-Away. Nat Protoc. 2018;13:2149-2175 pubmed publisher |
Fort L, Batista J, Thomason P, Spence H, Whitelaw J, Tweedy L, et al. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nat Cell Biol. 2018;20:1159-1171 pubmed publisher |
Peiris H, Park S, Louis S, Gu X, Lam J, Asplund O, et al. Discovering human diabetes-risk gene function with genetics and physiological assays. Nat Commun. 2018;9:3855 pubmed publisher |
Wang M, Yang W, Chen Y, Wang J, Tan J, Qiao W. Cellular RelB interacts with the transactivator Tat and enhance HIV-1 expression. Retrovirology. 2018;15:65 pubmed publisher |
Yang L, Zhou J, Meng F, Fu C, Zou X, Liu J, et al. G1 phase cell cycle arrest in NSCLC in response to LZ-106, an analog of enoxacin, is orchestrated through ROS overproduction in a P53-dependent manner. Carcinogenesis. 2019;40:131-144 pubmed publisher |
Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher |
Cohen C, Corpet A, Roubille S, Maroui M, Poccardi N, Rousseau A, et al. Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. PLoS Pathog. 2018;14:e1007313 pubmed publisher |
Yoshitomi H, Kobayashi S, Miyagawa Hayashino A, Okahata A, Doi K, Nishitani K, et al. Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments. Nat Commun. 2018;9:3762 pubmed publisher |
Tan X, Liao Z, Liang H, Chen X, Zhang B, Chu L. Upregulation of liver kinase B1 predicts poor prognosis in hepatocellular carcinoma. Int J Oncol. 2018;53:1913-1926 pubmed publisher |
McBrayer S, Mayers J, DiNatale G, Shi D, Khanal J, Chakraborty A, et al. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018;175:101-116.e25 pubmed publisher |
Moindrot B, Brockdorff N. Unbiased Genetic Screen to Identify Factors Involved in X-Chromosome Inactivation Using a Pooled Bar-Coded shRNA Library. Methods Mol Biol. 2018;1861:19-36 pubmed publisher |
Palazón Riquelme P, Worboys J, Green J, Valera A, Martín Sánchez F, Pellegrini C, et al. USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. EMBO Rep. 2018;19: pubmed publisher |
Gurusinghe S, Bandara N, Hilbert B, Trope G, Wang L, Strappe P. Lentiviral vector expression of Klf4 enhances chondrogenesis and reduces hypertrophy in equine chondrocytes. Gene. 2019;680:9-19 pubmed publisher |
Terzuoli E, Corti F, Nannelli G, Giachetti A, Donnini S, Ziche M. Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1. Int J Mol Sci. 2018;19: pubmed publisher |
Nguyen L, Zhao J, Cao D, Dang X, Wang L, Lian J, et al. Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection. Cell Death Dis. 2018;9:900 pubmed publisher |
Zhang L, Li X, Chao Y, He R, Liu J, Yuan Y, et al. KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer. Cell Commun Signal. 2018;16:53 pubmed publisher |
Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, et al. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018;:1-17 pubmed publisher |
Moreau T, Evans A, Ghevaert C. Differentiation of Human Pluripotent Stem Cells to Megakaryocytes by Transcription Factor-Driven Forward Programming. Methods Mol Biol. 2018;1812:155-176 pubmed publisher |
Wu C, Chiu W, Hsieh T, Hsieh C, Chen J. Modulation of motor excitability by cortical optogenetic theta burst stimulation. PLoS ONE. 2018;13:e0203333 pubmed publisher |
Walia M, Taylor S, Ho P, Martin T, Walkley C. Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53. Cell Death Dis. 2018;9:844 pubmed publisher |
Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E. G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. FASEB J. 2018;:fj201801123R pubmed publisher |
Schmidt F. Phenotypic Lentivirus Screens to Identify Antiviral Single Domain Antibodies. Methods Mol Biol. 2018;1836:139-158 pubmed publisher |
Xu D, Jin T, Zhu H, Chen H, Ofengeim D, Zou C, et al. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell. 2018;174:1477-1491.e19 pubmed publisher |
Madigan J, Hou F, Ye L, Hu J, Dong A, Tempel W, et al. The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. J Biol Chem. 2018;293:16142-16159 pubmed publisher |
Liessem Schmitz A, Teske N, Scheld M, Nyamoya S, Zendedel A, Beyer C, et al. Nrf2 Signaling in Sodium Azide-Treated Oligodendrocytes Restores Mitochondrial Functions. J Mol Neurosci. 2018;66:229-237 pubmed publisher |
Trinh H, Pham D, Choi Y, Kim H, Kim S, Park H. Epithelial folliculin enhances airway inflammation in aspirin-exacerbated respiratory disease. Clin Exp Allergy. 2018;48:1464-1473 pubmed publisher |
Tajan M, Hock A, Blagih J, Robertson N, Labuschagne C, Kruiswijk F, et al. A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Cell Metab. 2018;28:721-736.e6 pubmed publisher |
He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, et al. Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. Nat Commun. 2018;9:3310 pubmed publisher |
Tan Y, Jin C, Ma W, Hu Y, Tanasa B, Oh S, et al. Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program. Mol Cell. 2018;71:526-539.e8 pubmed publisher |
Logue S, McGrath E, Cleary P, Greene S, Mnich K, Almanza A, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018;9:3267 pubmed publisher |
Al Ahdal M, Murugaiah V, Varghese P, Abozaid S, Saba I, Al Qahtani A, et al. Entry Inhibition and Modulation of Pro-Inflammatory Immune Response Against Influenza A Virus by a Recombinant Truncated Surfactant Protein D. Front Immunol. 2018;9:1586 pubmed publisher |
Choi E, Yeo J, Yoon S, Lee J. Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication. Front Pharmacol. 2018;9:814 pubmed publisher |
Tomska K, Kurilov R, Lee K, Hüllein J, Lukas M, Sellner L, et al. Drug-based perturbation screen uncovers synergistic drug combinations in Burkitt lymphoma. Sci Rep. 2018;8:12046 pubmed publisher |
Seoane Collazo P, Roa J, Rial Pensado E, Liñares Pose L, Beiroa D, Ruiz Pino F, et al. SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity. Diabetes. 2018;67:2213-2226 pubmed publisher |
Kong Y, Rioja A, Xue X, Sun Y, Fu J, Putnam A. A systems mechanobiology model to predict cardiac reprogramming outcomes on different biomaterials. Biomaterials. 2018;181:280-292 pubmed publisher |
Fenini G, Grossi S, Contassot E, Biedermann T, Reichmann E, French L, et al. Genome Editing of Human Primary Keratinocytes by CRISPR/Cas9 Reveals an Essential Role of the NLRP1 Inflammasome in UVB Sensing. J Invest Dermatol. 2018;138:2644-2652 pubmed publisher |
Bernard S, Myers M, Fang W, Zinda B, Smart C, Lambert D, et al. CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms. J Mammary Gland Biol Neoplasia. 2018;23:249-267 pubmed publisher |
Scott A, Walker S, Krank J, Wilkinson A, Johnson K, Lewis E, et al. AIF promotes a JNK1-mediated cadherin switch independently of respiratory chain stabilization. J Biol Chem. 2018;293:14707-14722 pubmed publisher |
Bagchi R, Ferguson B, Stratton M, Hu T, Cavasin M, Sun L, et al. HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. JCI Insight. 2018;3: pubmed publisher |
Li C, Xu H, Xiao L, Zhu H, Zhang G, Wei W, et al. CRMP4a suppresses cell motility by sequestering RhoA activity in prostate cancer cells. Cancer Biol Ther. 2018;:1-11 pubmed publisher |
Kang C, Saso K, Ota K, Kawazu M, Ueda T, Okada H. JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities. Genes Cells. 2018;23:767-777 pubmed publisher |
Hiramuki Y, Tapscott S. Identification of SMCHD1 domains for nuclear localization, homo-dimerization, and protein cleavage. Skelet Muscle. 2018;8:24 pubmed publisher |
Canato S, Santos J, Carvalho A, Aloria K, Amaral M, Matthiesen R, et al. Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation. Cell Mol Life Sci. 2018;75:4495-4509 pubmed publisher |
Ye L, Wang C, Hong L, Sun N, Chen D, Chen S, et al. Programmable DNA repair with CRISPRa/i enhanced homology-directed repair efficiency with a single Cas9. Cell Discov. 2018;4:46 pubmed publisher |
Padilla Rodriguez M, Parker S, Adams D, Westerling T, Puleo J, Watson A, et al. The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nat Commun. 2018;9:2980 pubmed publisher |
Santos Vizcaino E, Haley H, Gonzalez Pujana A, Orive G, Hernandez R, Luker G, et al. Monitoring implantable immunoisolation devices with intrinsic fluorescence of genipin. J Biophotonics. 2019;12:e201800170 pubmed publisher |
Martinez Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, et al. An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell. 2018;174:1158-1171.e19 pubmed publisher |
Zhang D, Lin J, Chao Y, Zhang L, Jin L, Li N, et al. Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression. J Exp Clin Cancer Res. 2018;37:176 pubmed publisher |
Miller M, Shehat M, Alcedo K, Spinel L, SOULAKOVA J, Tigno Aranjuez J. Frontline Science: RIP2 promotes house dust mite-induced allergic airway inflammation. J Leukoc Biol. 2018;104:447-459 pubmed publisher |
Riley J, Quarato G, Cloix C, Lopez J, O Prey J, Pearson M, et al. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO J. 2018;37: pubmed publisher |
Joshi P, Yu K, Kang S, Kwon S, Kwon P, Dordick J, et al. 3D-cultured neural stem cell microarrays on a micropillar chip for high-throughput developmental neurotoxicology. Exp Cell Res. 2018;370:680-691 pubmed publisher |
Siddiquey M, Zhang H, Nguyen C, Domma A, Kamil J. The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response. J Virol. 2018;92: pubmed publisher |
Li Z, Jella K, Jaafar L, Li S, Park S, Story M, et al. Exposure to galactic cosmic radiation compromises DNA repair and increases the potential for oncogenic chromosomal rearrangement in bronchial epithelial cells. Sci Rep. 2018;8:11038 pubmed publisher |
Hua J, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, et al. Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Cell. 2018;174:564-575.e18 pubmed publisher |
Darnell A, Subramaniam A, O Shea E. Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Mol Cell. 2018;71:229-243.e11 pubmed publisher |
Wiame E, Tahay G, Tyteca D, Vertommen D, Stroobant V, Bommer G, et al. NAT6 acetylates the N-terminus of different forms of actin. FEBS J. 2018;285:3299-3316 pubmed publisher |
Liu J, Song T, Zhou W, Xing L, Wang S, Ho M, et al. A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity. Leukemia. 2019;33:171-180 pubmed publisher |
Hirai H, Yang B, Garcia Barrio M, Rom O, Ma P, Zhang J, et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors-Brief Report. Arterioscler Thromb Vasc Biol. 2018;38:2191-2197 pubmed publisher |
O Brien S, Lee K, Fu H, Lee Z, Le T, Stach C, et al. Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis. Biotechnol J. 2018;13:e1800226 pubmed publisher |
Dev H, Chiang T, Lescale C, de Krijger I, Martin A, Pilger D, et al. Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells. Nat Cell Biol. 2018;20:954-965 pubmed publisher |
Gao X, Chen Z, Li A, Zhang X, Cai X. MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma. Biomed Pharmacother. 2018;105:1072-1078 pubmed publisher |
Chirieleison S, Rathkey J, Abbott D. Unique BIR domain sets determine inhibitor of apoptosis protein-driven cell death and NOD2 complex signal specificity. Sci Signal. 2018;11: pubmed publisher |
Li W, Yu X, Ma X, Xie L, Xia Z, Liu L, et al. Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway. Cell Signal. 2018;50:131-141 pubmed publisher |
Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, et al. Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis. Nat Commun. 2018;9:2733 pubmed publisher |
Yeo N, Chavez A, Lance Byrne A, Chan Y, Menn D, Milanova D, et al. An enhanced CRISPR repressor for targeted mammalian gene regulation. Nat Methods. 2018;15:611-616 pubmed publisher |
Zingg D, Debbache J, Peña Hernández R, Antunes A, Schaefer S, Cheng P, et al. EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation. Cancer Cell. 2018;34:69-84.e14 pubmed publisher |
Ci Y, Yang Y, Xu C, Shi L. Vesicular stomatitis virus G protein transmembrane region is crucial for the hemi-fusion to full fusion transition. Sci Rep. 2018;8:10669 pubmed publisher |
Nguyen C, Siddiquey M, Zhang H, Li G, Kamil J. Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO. J Virol. 2018;92: pubmed publisher |
Amick J, Tharkeshwar A, Amaya C, Ferguson S. WDR41 supports lysosomal response to changes in amino acid availability. Mol Biol Cell. 2018;29:2213-2227 pubmed publisher |
Tokuo H, Bhawan J, Coluccio L. Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018;8:10449 pubmed publisher |
Fornabaio G, Barnhill R, Lugassy C, Bentolila L, Cassoux N, Roman Roman S, et al. Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model. Sci Rep. 2018;8:10448 pubmed publisher |
Samavarchi Tehrani P, Abdouni H, Samson R, Gingras A. A Versatile Lentiviral Delivery Toolkit for Proximity-dependent Biotinylation in Diverse Cell Types. Mol Cell Proteomics. 2018;17:2256-2269 pubmed publisher |
El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, et al. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018;136:537-555 pubmed publisher |
Durán Alonso M, López Hernández I, de la Fuente M, Garcia Sancho J, Giraldez F, Schimmang T. Transcription factor induced conversion of human fibroblasts towards the hair cell lineage. PLoS ONE. 2018;13:e0200210 pubmed publisher |
Kok Y, Schmutz S, Inderbitzin A, Neumann K, Kelley A, Jörimann L, et al. Spontaneous reactivation of latent HIV-1 promoters is linked to the cell cycle as revealed by a genetic-insulators-containing dual-fluorescence HIV-1-based vector. Sci Rep. 2018;8:10204 pubmed publisher |
Lee S, Oh Y, Lü Y, Kim W, Yoo A. MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts. Dev Cell. 2018;46:73-84.e7 pubmed publisher |
Shao J, Wang M, Yu G, Zhu S, Yu Y, Heng B, et al. Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Proc Natl Acad Sci U S A. 2018;115:E6722-E6730 pubmed publisher |
Rajan S, Panzade G, Srivastava A, Shankar K, Pandey R, Kumar D, et al. miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin. J Endocrinol. 2018;: pubmed publisher |
Pulikkan J, Hegde M, Ahmad H, Belaghzal H, Illendula A, Yu J, et al. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. 2018;174:172-186.e21 pubmed publisher |
Choy M, Javierre B, Williams S, Baross S, Liu Y, Wingett S, et al. Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks. Nat Commun. 2018;9:2526 pubmed publisher |
Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, et al. Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation. Sci Rep. 2018;8:9745 pubmed publisher |
Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed publisher |
Comenge J, Sharkey J, Fragueiro O, Wilm B, Brust M, Murray P, et al. Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes. elife. 2018;7: pubmed publisher |
Anastasiadou E, Stroopinsky D, Alimperti S, Jiao A, Pyzer A, Cippitelli C, et al. Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia. 2019;33:132-147 pubmed publisher |
Iwadate M, Takizawa Y, Shirai Y, Kimura S. An in vivo model for thyroid regeneration and folliculogenesis. Lab Invest. 2018;98:1126-1132 pubmed publisher |
Garri C, Howell S, Tiemann K, Tiffany A, Jalali Yazdi F, Alba M, et al. Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Oncotarget. 2018;9:27363-27379 pubmed publisher |
Pavlyukov M, Yu H, Bastola S, Minata M, Shender V, Lee Y, et al. Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors. Cancer Cell. 2018;34:119-135.e10 pubmed publisher |
Messenger S, Woo S, Sun Z, Martin T. A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4. J Cell Biol. 2018;217:2877-2890 pubmed publisher |
Stewart S, Ashkenazi A, Williamson A, Rubinsztein D, Moreau K. Transbilayer phospholipid movement facilitates the translocation of annexin across membranes. J Cell Sci. 2018;131: pubmed publisher |
Higelin J, Catanese A, Semelink Sedlacek L, Oeztuerk S, Lutz A, Bausinger J, et al. NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons. Stem Cell Res. 2018;30:150-162 pubmed publisher |
Kaneko S, Li X. X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Sci Adv. 2018;4:eaar5598 pubmed publisher |
Kitamura K, Que L, Shimadu M, Koura M, Ishihara Y, Wakae K, et al. Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus. PLoS Pathog. 2018;14:e1007124 pubmed publisher |
Liu X, Zhang Y, Chen Y, Li M, Shao Z, Zhang M, et al. CAPTURE: In Situ Analysis of Chromatin Composition of Endogenous Genomic Loci by Biotinylated dCas9. Curr Protoc Mol Biol. 2018;123:e64 pubmed publisher |
Phelan J, Young R, Webster D, Roulland S, Wright G, Kasbekar M, et al. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature. 2018;560:387-391 pubmed publisher |
Fernandopulle M, Prestil R, Grunseich C, Wang C, Gan L, Ward M. Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons. Curr Protoc Cell Biol. 2018;79:e51 pubmed publisher |
Lotfi P, Tse D, di Ronza A, Seymour M, Martano G, Cooper J, et al. Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency. Autophagy. 2018;14:1419-1434 pubmed publisher |
Torres P, Ramírez Nuñez O, Romero Guevara R, Barés G, Granado Serrano A, Ayala V, et al. Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue. Autophagy. 2018;14:1398-1403 pubmed publisher |
Schätzle P, Esteves da Silva M, Tas R, Katrukha E, Hu H, Wierenga C, et al. Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry. Curr Biol. 2018;28:2081-2093.e6 pubmed publisher |
Coyne E, Bedard N, Wykes L, Stretch C, Jammoul S, Li S, et al. Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling. Endocrinology. 2018;159:2966-2977 pubmed publisher |
Zhao X, Zhang C, Le Z, Zeng S, Pan C, Shi J, et al. Telomerase reverse transcriptase interference synergistically promotes tumor necrosis factor‑related apoptosis‑inducing ligand‑induced oral squamous cell carcinoma apoptosis and suppresses proliferation in vitro and in vivo. Int J Mol Med. 2018;42:1283-1294 pubmed publisher |
Komatsu N, Terai K, Imanishi A, Kamioka Y, Sumiyama K, Jin T, et al. A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging. Sci Rep. 2018;8:8984 pubmed publisher |
Galarza Torre A, Shaw J, Wood A, Gilbert H, Dobre O, Genever P, et al. An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness. Sci Rep. 2018;8:8981 pubmed publisher |
Davila A, Liu L, Chellappa K, Redpath P, Nakamaru Ogiso E, Paolella L, et al. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. elife. 2018;7: pubmed publisher |
Haapaniemi E, Botla S, Persson J, Schmierer B, Taipale J. CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat Med. 2018;24:927-930 pubmed publisher |
Liu T, Kong W, Tang X, Xu M, Wang Q, Zhang B, et al. The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells. Cell Death Dis. 2018;9:677 pubmed publisher |
Wu D, Wang W, Chen W, Lian F, Lang L, Huang Y, et al. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. Haematologica. 2018;103:1472-1483 pubmed publisher |
Gardner M, Glaunsinger B. Kaposi's Sarcoma-Associated Herpesvirus ORF68 Is a DNA Binding Protein Required for Viral Genome Cleavage and Packaging. J Virol. 2018;92: pubmed publisher |
Xie S, Cooley A, Armendariz D, Zhou P, Hon G. Frequent sgRNA-barcode recombination in single-cell perturbation assays. PLoS ONE. 2018;13:e0198635 pubmed publisher |
Suryadevara C, Desai R, Abel M, Riccione K, Batich K, Shen S, et al. Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma. Oncoimmunology. 2018;7:e1434464 pubmed publisher |
Hemming M, Lawlor M, Zeid R, Lesluyes T, Fletcher J, Raut C, et al. Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome. Proc Natl Acad Sci U S A. 2018;115:E5746-E5755 pubmed publisher |
Sanchez D, Steger D, Skuli N, Bansal A, Simon M. PPARγ is dispensable for clear cell renal cell carcinoma progression. Mol Metab. 2018;14:139-149 pubmed publisher |
Walton Z, Patel C, Brooks R, Yu Y, Ibrahim Hashim A, Riddle M, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. 2018;174:72-87.e32 pubmed publisher |
Stojic L, Lun A, Mangei J, Mascalchi P, Quarantotti V, Barr A, et al. Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis. Nucleic Acids Res. 2018;46:5950-5966 pubmed publisher |
Bao L, Chen Y, Lai H, Wu S, Wang J, Hatanpaa K, et al. Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. Nucleic Acids Res. 2018;46:6576-6591 pubmed publisher |
Bondar V, Adamski C, Onur T, Tan Q, Wang L, Díaz García J, et al. PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1. Hum Mol Genet. 2018;27:2863-2873 pubmed publisher |
Liang Y, Tebaldi T, Rejeski K, Joshi P, Stefani G, Taylor A, et al. SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells. Leukemia. 2018;32:2659-2671 pubmed publisher |
Suzuki I, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, et al. Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation. Cell. 2018;173:1370-1384.e16 pubmed publisher |
Huang L, Tam K, Liu W, Lin C, Hsu K, Hsieh W, et al. CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Dis Markers. 2018;2018:3835783 pubmed publisher |
Dudek A, Pfaff F, Bolte H, Waguia Kontchou C, Schwemmle M. Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage. J Virol. 2018;92: pubmed publisher |
Abdul F, Filleton F, Gerossier L, Paturel A, Hall J, Strubin M, et al. Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals. J Virol. 2018;92: pubmed publisher |
Mallery D, Márquez C, McEwan W, Dickson C, Jacques D, Anandapadamanaban M, et al. IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. elife. 2018;7: pubmed publisher |
Bojang P, Ramos K. Epigenetic reactivation of LINE-1 retrotransposon disrupts NuRD corepressor functions and induces oncogenic transformation in human bronchial epithelial cells. Mol Oncol. 2018;12:1342-1357 pubmed publisher |
Hegde M, Strand C, Hanna R, Doench J. Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens. PLoS ONE. 2018;13:e0197547 pubmed publisher |
Ng S, Yoshida N, Christie A, Ghandi M, Dharia N, Dempster J, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun. 2018;9:2024 pubmed publisher |
Yang T, Chong W, Wang W, Mazo G, Tanos B, Chen Z, et al. Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components. Nat Commun. 2018;9:2023 pubmed publisher |
Zhu B, Tang L, Chen S, Yin C, Peng S, Li X, et al. Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Oncogene. 2018;37:4941-4954 pubmed publisher |
García Peydró M, Fuentes P, Mosquera M, García León M, Alcain J, Rodriguez A, et al. The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model. J Clin Invest. 2018;128:2802-2818 pubmed publisher |
Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes Hasler P, et al. The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification. Cell Host Microbe. 2018;23:766-774.e5 pubmed publisher |
Yosefzon Y, Soteriou D, Feldman A, Kostić L, Koren E, Brown S, et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell. 2018;70:573-587.e4 pubmed publisher |
Ophinni Y, Inoue M, Kotaki T, Kameoka M. CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures. Sci Rep. 2018;8:7784 pubmed publisher |
Zhang R, Kim A, Fox J, Nair S, Basore K, Klimstra W, et al. Mxra8 is a receptor for multiple arthritogenic alphaviruses. Nature. 2018;557:570-574 pubmed publisher |
López Benito S, Sánchez Sánchez J, Brito V, Calvo L, Lisa S, Torres Valle M, et al. Regulation of BDNF Release by ARMS/Kidins220 through Modulation of Synaptotagmin-IV Levels. J Neurosci. 2018;38:5415-5428 pubmed publisher |
Huynh N, Brunger J, Gloss C, Moutos F, Gersbach C, Guilak F. Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. Tissue Eng Part A. 2018;24:1531-1544 pubmed publisher |
Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, et al. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLoS ONE. 2018;13:e0197046 pubmed publisher |
Cheung A, Chow C, Zhang J, Zhou Y, Huang T, Ng K, et al. Specific targeting of point mutations in EGFR L858R-positive lung cancer by CRISPR/Cas9. Lab Invest. 2018;98:968-976 pubmed publisher |
Ottaviani S, Stebbing J, Frampton A, Zagorac S, Krell J, de Giorgio A, et al. TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. Nat Commun. 2018;9:1845 pubmed publisher |
Buttler C, Pezeshkian N, Fernandez M, Aaron J, Norman S, Freed E, et al. Single molecule fate of HIV-1 envelope reveals late-stage viral lattice incorporation. Nat Commun. 2018;9:1861 pubmed publisher |
Ryu K, Nandu T, Kim J, Challa S, DeBerardinis R, Kraus W. Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis. Science. 2018;360: pubmed publisher |
Yu Z, Surface L, Park C, Horlbeck M, Wyant G, Abu Remaileh M, et al. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. elife. 2018;7: pubmed publisher |
Er J, Goh P, Lee C, Tan Y, Hii L, Mai C, et al. Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC). Apoptosis. 2018;23:343-355 pubmed publisher |
Simpson S, Fiches G, Jean M, Dieringer M, McGuinness J, John S, et al. Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi's Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells. Front Microbiol. 2018;9:788 pubmed publisher |
Ding Q, Nimgaonkar I, Archer N, Bram Y, Heller B, Schwartz R, et al. Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription. MBio. 2018;9: pubmed publisher |
Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam A, Sattentau Q, Meinhart A, et al. RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Mol Cell. 2018;70:650-662.e8 pubmed publisher |
Wang Y, Wong C, Yan M, Li L, Liu T, Or P, et al. Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma. Cancer Lett. 2018;429:54-65 pubmed publisher |
Chen G, Zhang D, Zhang L, Feng G, Zhang B, Wu Y, et al. RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Biochem Biophys Res Commun. 2018;501:259-265 pubmed publisher |
Cohen I, Zhao D, Bar C, Valdes V, Dauber Decker K, Nguyen M, et al. PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification. Cell Stem Cell. 2018;22:726-739.e7 pubmed publisher |
Ma L, Zhao Q, Chen W, Zhang Y. Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner. Oncol Lett. 2018;15:6975-6981 pubmed publisher |
Park J, Lee C, Cheng J, Morgan E. Posttranslational regulation of CYP2J2 by nitric oxide. Free Radic Biol Med. 2018;121:149-156 pubmed publisher |
Boehmerle W, Huehnchen P, Lee S, Harms C, Endres M. TRPV4 inhibition prevents paclitaxel-induced neurotoxicity in preclinical models. Exp Neurol. 2018;306:64-75 pubmed publisher |
Wang Y, Chen D, Chen M, Ji K, Ma D, Zhou L. A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay. J Vis Exp. 2018;: pubmed publisher |
Zhang Z, Wan T, Chen Y, Chen Y, Sun H, Cao T, et al. Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing. Macromol Rapid Commun. 2019;40:e1800068 pubmed publisher |
Darzi S, Deane J, Nold C, Edwards S, Gough D, Mukherjee S, et al. Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice. Sci Rep. 2018;8:6554 pubmed publisher |
Thakore P, Kwon J, Nelson C, Rouse D, Gemberling M, Oliver M, et al. RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. Nat Commun. 2018;9:1674 pubmed publisher |
Ge J, Burnier L, Adamopoulou M, Kwa M, Schaks M, Rottner K, et al. RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem. 2018;293:9358-9369 pubmed publisher |
Blum W, Pecze L, Rodriguez J, Steinauer M, Schwaller B. Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter. BMC Cancer. 2018;18:475 pubmed publisher |
Sidarovich V, De Mariano M, Aveic S, Pancher M, Adami V, Gatto P, et al. A High-Content Screening of Anticancer Compounds Suggests the Multiple Tyrosine Kinase Inhibitor Ponatinib for Repurposing in Neuroblastoma Therapy. Mol Cancer Ther. 2018;17:1405-1415 pubmed publisher |
Mucha O, Podkalicka P, Czarnek M, Biela A, Mieczkowski M, Kachamakova Trojanowska N, et al. Pharmacological versus genetic inhibition of heme oxygenase-1 - the comparison of metalloporphyrins, shRNA and CRISPR/Cas9 system. Acta Biochim Pol. 2018;65:277-286 pubmed publisher |
Jones B, Buenaventura T, Kanda N, Chabosseau P, Owen B, Scott R, et al. Targeting GLP-1 receptor trafficking to improve agonist efficacy. Nat Commun. 2018;9:1602 pubmed publisher |
Rietscher K, Keil R, Jordan A, Hatzfeld M. 14-3-3 proteins regulate desmosomal adhesion via plakophilins. J Cell Sci. 2018;131: pubmed publisher |
Zhou A, Shi G, Kang G, Xie A, Liu H, Jiang N, et al. RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA. J Am Heart Assoc. 2018;7: pubmed publisher |
Bester A, Lee J, Chavez A, Lee Y, Nachmani D, Vora S, et al. An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Cell. 2018;173:649-664.e20 pubmed publisher |
Zhou Z, Wang W, Xie X, Song Y, Dang C, Zhang H. Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway. Biochem Biophys Res Commun. 2018;500:411-417 pubmed publisher |
Bambousková M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, et al. Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature. 2018;556:501-504 pubmed publisher |
Xue Z, Zhang Z, Liu H, Li W, Guo X, Zhang Z, et al. lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Cell Death Differ. 2019;26:130-145 pubmed publisher |
Luo Q, Wu X, Zhang Y, Shu T, Ding F, Chen H, et al. ARID1A ablation leads to multiple drug resistance in ovarian cancer via transcriptional activation of MRP2. Cancer Lett. 2018;427:9-17 pubmed publisher |
Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, et al. Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7. Aging Cell. 2018;17:e12765 pubmed publisher |
Barczak W, Sobecka A, Golusinski P, Masternak M, Rubis B, Suchorska W, et al. hTERT gene knockdown enhances response to radio- and chemotherapy in head and neck cancer cell lines through a DNA damage pathway modification. Sci Rep. 2018;8:5949 pubmed publisher |
Duellman T, Chen X, Wakamiya R, Yang J. Nucleic acid-induced potentiation of matrix metalloproteinase-9 enzymatic activity. Biochem J. 2018;475:1597-1610 pubmed publisher |
Raposo T, Comes M, Idowu A, Agit B, Hassall J, Fadhil W, et al. CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Exp Mol Pathol. 2018;104:190-198 pubmed publisher |
Canver M, Haeussler M, Bauer D, Orkin S, Sanjana N, Shalem O, et al. Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments. Nat Protoc. 2018;13:946-986 pubmed publisher |
Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, et al. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nat Commun. 2018;9:1411 pubmed publisher |
Francis A, Melikyan G. Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport. Cell Host Microbe. 2018;23:536-548.e6 pubmed publisher |
Wei C, Lin H, Cui S. The Forkhead Transcription Factor FOXC2 Is Required for Maintaining Murine Spermatogonial Stem Cells. Stem Cells Dev. 2018;27:624-636 pubmed publisher |
Neshati V, Mollazadeh S, Fazly Bazzaz B, de Vries A, Mojarrad M, Naderi Meshkin H, et al. Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors. J Cell Biochem. 2018;119:6146-6153 pubmed publisher |
Xiong J, Almeida M, O Brien C. The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone. 2018;112:1-9 pubmed publisher |
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, et al. lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. Cancer Cell. 2018;33:706-720.e9 pubmed publisher |
Shao J, Glorieux C, Liao J, Chen P, Lu W, Liang Z, et al. Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo. Free Radic Res. 2018;52:661-671 pubmed publisher |
Ren J, Jian F, Jiang H, Sun Y, Pan S, Gu C, et al. Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling. Int J Oncol. 2018;52:1934-1946 pubmed publisher |
Gao F, Li G, Liu C, Gao H, Wang H, Liu W, et al. Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. J Cell Biol. 2018;217:2103-2119 pubmed publisher |
Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi P, Wang Y, et al. Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Cell Rep. 2018;23:255-269.e4 pubmed publisher |
Dasgupta S, Rajapakshe K, Zhu B, Nikolai B, Yi P, Putluri N, et al. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018;556:249-254 pubmed publisher |
Zhang C, Peng Y, Hublitz P, Zhang H, Dong T. Genetic abrogation of immune checkpoints in antigen-specific cytotoxic T-lymphocyte as a potential alternative to blockade immunotherapy. Sci Rep. 2018;8:5549 pubmed publisher |
Mrazkova B, Dzijak R, Imrichova T, Kyjacova L, Barath P, Dzubak P, et al. Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence. Aging (Albany NY). 2018;10:434-462 pubmed publisher |
Horibata S, Rice E, Mukai C, Marks B, Sams K, Zheng H, et al. ER-positive breast cancer cells are poised for RET-mediated endocrine resistance. PLoS ONE. 2018;13:e0194023 pubmed publisher |
Nabet B, Roberts J, Buckley D, Paulk J, Dastjerdi S, Yang A, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018;14:431-441 pubmed publisher |
DeCicco RePass M, Bhat N, Heimburg Molinaro J, BUNNELL S, Cummings R, Ward H. Molecular cloning, expression, and characterization of UDP N-acetyl-α-d-galactosamine: Polypeptide N-acetylgalactosaminyltransferase 4 from Cryptosporidium parvum. Mol Biochem Parasitol. 2018;221:56-65 pubmed publisher |
Miller I, Gamboa Castro M, Maenza J, Weis J, Kwong G. Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains. ACS Synth Biol. 2018;7:1167-1173 pubmed publisher |
Sack L, Davoli T, Li M, Li Y, Xu Q, Naxerova K, et al. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. 2018;173:499-514.e23 pubmed publisher |
Neshati V, Mollazadeh S, Fazly Bazzaz B, de Vries A, Mojarrad M, Naderi Meshkin H, et al. MicroRNA-499a-5p Promotes Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells to Cardiomyocytes. Appl Biochem Biotechnol. 2018;186:245-255 pubmed publisher |
Frazier H, Anderson K, Maimaiti S, Ghoweri A, Kraner S, Popa G, et al. Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents. Neurochem Res. 2019;44:269-280 pubmed publisher |
Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018;173:74-89.e20 pubmed publisher |
Gialesaki S, Mahnken A, Schmid L, Labuhn M, Bhayadia R, Heckl D, et al. GATA1s exerts developmental stage-specific effects in human hematopoiesis. Haematologica. 2018;103:e336-e340 pubmed publisher |
Silagi E, Batista P, Shapiro I, Risbud M. Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death. Sci Rep. 2018;8:4856 pubmed publisher |
Pappas B, Yang Y, Wang Y, Kim K, Chung H, Cheung M, et al. p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism. Biochem Pharmacol. 2018;152:34-44 pubmed publisher |
Roesch F, OhAinle M, Emerman M. A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery. Retrovirology. 2018;15:26 pubmed publisher |
Leko V, Sripathy S, Adrianse R, Loe T, Park A, Lao U, et al. Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome. J Vis Exp. 2018;: pubmed publisher |
Zhang X, Martin T. High Throughput NPY-Venus and Serotonin Secretion Assays for Regulated Exocytosis in Neuroendocrine Cells. Bio Protoc. 2018;8: pubmed publisher |
Sertic S, Mollica A, Campus I, Roma S, Tumini E, Aguilera A, et al. Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions. Mol Cell. 2018;70:34-47.e4 pubmed publisher |
Konermann S, Lotfy P, Brideau N, Oki J, Shokhirev M, Hsu P. Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors. Cell. 2018;173:665-676.e14 pubmed publisher |
Suphatrakul A, Duangchinda T, Jupatanakul N, Prasittisa K, Onnome S, Pengon J, et al. Multi-color fluorescent reporter dengue viruses with improved stability for analysis of a multi-virus infection. PLoS ONE. 2018;13:e0194399 pubmed publisher |
Heffernan C, Maurel P. Lentiviral Transduction of Rat Schwann Cells and Dorsal Root Ganglia Neurons for In Vitro Myelination Studies. Methods Mol Biol. 2018;1739:177-193 pubmed publisher |
Zhang Z, Xue Z, Liu Y, Liu H, Guo X, Li Y, et al. MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis. Brain Behav Immun. 2018;70:305-314 pubmed publisher |
Johnson J, Lucas S, Amon L, Skelton S, Nazitto R, Carbonetti S, et al. Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Cell Host Microbe. 2018;23:366-381.e9 pubmed publisher |
Sprague L, Lee J, Hutzen B, Wang P, Chen C, Conner J, et al. High Mobility Group Box 1 Influences HSV1716 Spread and Acts as an Adjuvant to Chemotherapy. Viruses. 2018;10: pubmed publisher |
Bonfim Melo A, Ferreira d, Mortara R. Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. Front Microbiol. 2018;9:360 pubmed publisher |
Takaku M, Grimm S, Roberts J, Chrysovergis K, Bennett B, Myers P, et al. GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network. Nat Commun. 2018;9:1059 pubmed publisher |
Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, et al. PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Cancer Cell. 2018;33:355-367.e7 pubmed publisher |
Campbell A, Shadle S, Jagannathan S, Lim J, Resnick R, Tawil R, et al. NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. elife. 2018;7: pubmed publisher |
Shimobayashi M, Albert V, Woelnerhanssen B, Frei I, Weissenberger D, Meyer Gerspach A, et al. Insulin resistance causes inflammation in adipose tissue. J Clin Invest. 2018;128:1538-1550 pubmed publisher |
Tarumoto Y, Lu B, Somerville T, Huang Y, Milazzo J, Wu X, et al. LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Mol Cell. 2018;69:1017-1027.e6 pubmed publisher |
Johnson B, Vanblargan L, Xu W, White J, Shan C, Shi P, et al. Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity. 2018;48:487-499.e5 pubmed publisher |
Klann T, Crawford G, Reddy T, Gersbach C. Screening Regulatory Element Function with CRISPR/Cas9-based Epigenome Editing. Methods Mol Biol. 2018;1767:447-480 pubmed publisher |
Goubert D, Koncz M, Kiss A, Rots M. Establishment of Cell Lines Stably Expressing dCas9-Fusions to Address Kinetics of Epigenetic Editing. Methods Mol Biol. 2018;1767:395-415 pubmed publisher |
Sng C, O Byrne S, Prigozhin D, Bauer M, Harvey J, Ruhle M, et al. A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway. J Allergy Clin Immunol. 2018;142:311-314.e6 pubmed publisher |
Limpose K, Trego K, Li Z, Leung S, Sarker A, Shah J, et al. Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Nucleic Acids Res. 2018;46:4515-4532 pubmed publisher |
Chu L, Indramohan M, Ratsimandresy R, Gangopadhyay A, Morris E, Monack D, et al. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018;9:996 pubmed publisher |
Ikezu T, Chen C, Deleo A, Zeldich E, Fallin M, Kanaan N, et al. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. J Neuroimmune Pharmacol. 2018;13:254-264 pubmed publisher |
Makhov P, Naito S, Haifler M, Kutikov A, Boumber Y, Uzzo R, et al. The convergent roles of NF-κB and ER stress in sunitinib-mediated expression of pro-tumorigenic cytokines and refractory phenotype in renal cell carcinoma. Cell Death Dis. 2018;9:374 pubmed publisher |
Liu R, Merola J, Manes T, Qin L, Tietjen G, Lopez Giraldez F, et al. Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1. JCI Insight. 2018;3: pubmed publisher |
Wang T, Du Q, Wu X, Niu Y, Guan L, Wang Z, et al. Porcine MKRN1 Modulates the Replication and Pathogenesis of Porcine Circovirus Type 2 by Inducing Capsid Protein Ubiquitination and Degradation. J Virol. 2018;92: pubmed publisher |
Tarbet H, Dolat L, Smith T, Condon B, O Brien E, Valdivia R, et al. Site-specific glycosylation regulates the form and function of the intermediate filament cytoskeleton. elife. 2018;7: pubmed publisher |
Okada K, Nogami A, Ishida S, Akiyama H, Chen C, Umezawa Y, et al. FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Oncotarget. 2018;9:8870-8886 pubmed publisher |
Gechijian L, Buckley D, Lawlor M, Reyes J, Paulk J, Ott C, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018;14:405-412 pubmed publisher |
Wang L, Wrobel J, Xie L, Li D, Zurlo G, Shen H, et al. Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer. Cell Chem Biol. 2018;25:619-633.e5 pubmed publisher |
Garner K, Betin V, Pinto V, Graham M, Abgueguen E, Barnes M, et al. Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. Sci Rep. 2018;8:3902 pubmed publisher |
Behera S, Kapadia B, Kain V, Alamuru Yellapragada N, Murunikkara V, Kumar S, et al. ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1702-1716 pubmed publisher |
Miller K, Garza Mayers A, Leung Y, Goldberg M. Identification of interactions among host and bacterial proteins and evaluation of their role early during Shigella flexneri infection. Microbiology. 2018;164:540-550 pubmed publisher |
Correnti C, Gewe M, Mehlin C, Bandaranayake A, Johnsen W, Rupert P, et al. Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018;25:270-278 pubmed publisher |
Kapadia B, Nanaji N, Bhalla K, Bhandary B, Lapidus R, Beheshti A, et al. Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL. Nat Commun. 2018;9:829 pubmed publisher |
Pliatska M, Kapasa M, Kokkalis A, Polyzos A, Thanos D. The Histone Variant MacroH2A Blocks Cellular Reprogramming by Inhibiting Mesenchymal-to-Epithelial Transition. Mol Cell Biol. 2018;38: pubmed publisher |
Chatterjee S, Biswas M, Boila L, Banerjee D, Sengupta A. SMARCB1 Deficiency Integrates Epigenetic Signals to Oncogenic Gene Expression Program Maintenance in Human Acute Myeloid Leukemia. Mol Cancer Res. 2018;16:791-804 pubmed publisher |
Grenier A, Sujobert P, Olivier S, Guermouche H, Mondesir J, Kosmider O, et al. Knockdown of Human AMPK Using the CRISPR/Cas9 Genome-Editing System. Methods Mol Biol. 2018;1732:171-194 pubmed publisher |
Behrens G, Winzen R, Rehage N, Dörrie A, Barsch M, Hoffmann A, et al. A translational silencing function of MCPIP1/Regnase-1 specified by the target site context. Nucleic Acids Res. 2018;46:4256-4270 pubmed publisher |
Wang C, Zhou H, Xue Y, Liang J, Narita Y, Gerdt C, et al. Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300. J Virol. 2018;92: pubmed publisher |
Hesse R, von Einem B, Wagner F, Bott P, Schwanzar D, Jackson R, et al. sAPPβ and sAPPα increase structural complexity and E/I input ratio in primary hippocampal neurons and alter Ca2+ homeostasis and CREB1-signaling. Exp Neurol. 2018;304:1-13 pubmed publisher |
Herling C, Abedpour N, Weiss J, Schmitt A, Jachimowicz R, Merkel O, et al. Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia. Nat Commun. 2018;9:727 pubmed publisher |
Sun X, Yang Y, Zhong X, Cao Q, Zhu X, Zhu X, et al. A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism. Autophagy. 2018;14:38-52 pubmed publisher |
Wurdak M, Schneider M, Iftner T, Stubenrauch F. The contribution of SP100 to cottontail rabbit papillomavirus transcription and replication. J Gen Virol. 2018;: pubmed publisher |
Srivastava A, Shankar K, Beg M, Rajan S, Gupta A, Varshney S, et al. Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor. J Mol Med (Berl). 2018;96:315-331 pubmed publisher |
Zhou A, Xie A, Kim T, Liu H, Shi G, Kang G, et al. HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure. Heart Rhythm. 2018;15:1072-1080 pubmed publisher |
Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, et al. A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection. PLoS Pathog. 2018;14:e1006884 pubmed publisher |
Yang B, Li M, Tang W, Liu W, Zhang S, Chen L, et al. Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma. Nat Commun. 2018;9:678 pubmed publisher |
Novas R, Cardenas Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello M, et al. Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Sci Rep. 2018;8:3019 pubmed publisher |
Martin N, Myers P, Goulding E, Chen S, Walker M, Porter T, et al. En masse lentiviral gene delivery to mouse fertilized eggs via laser perforation of zona pellucida. Transgenic Res. 2018;27:39-49 pubmed publisher |
Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher |
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, et al. MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development. J Exp Clin Cancer Res. 2018;37:28 pubmed publisher |
Fang C, Dai C, Mei Z, Jiang M, Gu D, Huang Q, et al. microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings. J Exp Clin Cancer Res. 2018;37:25 pubmed publisher |
Ernst A, Putscher A, Samatov T, Suling A, Galatenko V, Shkurnikov M, et al. Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy. PLoS ONE. 2018;13:e0192525 pubmed publisher |
Relation T, Yi T, Guess A, La Perle K, Otsuru S, Hasgur S, et al. Intratumoral Delivery of Interferonγ-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018;36:915-924 pubmed publisher |
Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T. The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression. Mol Cell. 2018;69:622-635.e6 pubmed publisher |
Everman J, Rios C, Seibold M. Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9. Methods Mol Biol. 2018;1706:267-292 pubmed publisher |
Li M, Yu X, Li W, Liu T, Deng G, Liu W, et al. Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway. Oncotarget. 2018;9:152-166 pubmed publisher |
Maier M, Baldwin C, Aoudjit L, Takano T. The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. Int J Mol Sci. 2018;19: pubmed publisher |
Yang X, Hu Z, Fan S, Zhang Q, Zhong Y, Guo D, et al. Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. PLoS Pathog. 2018;14:e1006901 pubmed publisher |
Pellicelli M, Hariri H, Miller J, St Arnaud R. Lrp6 is a target of the PTH-activated ?NAC transcriptional coregulator. Biochim Biophys Acta Gene Regul Mech. 2018;1861:61-71 pubmed publisher |
Jafarnejad S, Chapat C, Matta Camacho E, Gelbart I, Hesketh G, Arguello M, et al. Translational control of ERK signaling through miRNA/4EHP-directed silencing. elife. 2018;7: pubmed publisher |
Ferrucci F, Ciaccio R, Monticelli S, Pigini P, Di Giacomo S, Purgato S, et al. MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma. Biochim Biophys Acta Gene Regul Mech. 2018;1861:235-245 pubmed publisher |
Kim S, Song J, Ahn J, Lee G, Ahn H, Yoon S, et al. Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation. Antiviral Res. 2018;151:87-96 pubmed publisher |
Yeung Y, Yin S, Lu B, Fan S, Yang R, Bai R, et al. Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization. EBioMedicine. 2018;28:51-61 pubmed publisher |
Guo Q, Lehmer C, Martinez Sanchez A, Rudack T, Beck F, Hartmann H, et al. In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell. 2018;172:696-705.e12 pubmed publisher |
Zheng Y, Sethi R, Mangala L, Taylor C, Goldsmith J, Wang M, et al. Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Nat Commun. 2018;9:476 pubmed publisher |
Okondo M, Rao S, Taabazuing C, Chui A, Poplawski S, Johnson D, et al. Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Cell Chem Biol. 2018;25:262-267.e5 pubmed publisher |
Hsu K, Huang C, Tam K, Lin C, Huang L, Lin C, et al. The Application of Non-Invasive Apoptosis Detection Sensor (NIADS) on Histone Deacetylation Inhibitor (HDACi)-Induced Breast Cancer Cell Death. Int J Mol Sci. 2018;19: pubmed publisher |
Kalantari P, Morales Y, Miller E, Jaramillo L, Ponichtera H, Wuethrich M, et al. CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology. Cell Rep. 2018;22:1288-1300 pubmed publisher |
Palau A, Garz A, Diesch J, Zwick A, Malinverni R, Valero V, et al. Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes. Oncotarget. 2017;8:115002-115017 pubmed publisher |
Ye W, Han T, Nassar L, Zubia M, Jan Y, Jan L. Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018;115:E1667-E1674 pubmed publisher |
McClurg U, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, et al. Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. Br J Cancer. 2018;118:713-726 pubmed publisher |
Danko C, Choate L, Marks B, Rice E, Wang Z, Chu T, et al. Dynamic evolution of regulatory element ensembles in primate CD4+ T cells. Nat Ecol Evol. 2018;2:537-548 pubmed publisher |
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, et al. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 2018;37: pubmed publisher |
Oikawa T, Otsuka Y, Onodera Y, Horikawa M, Handa H, Hashimoto S, et al. Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity. Sci Rep. 2018;8:1595 pubmed publisher |
Trussart C, Pirlot C, Di Valentin E, Piette J, Habraken Y. Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response. Biochem Pharmacol. 2018;153:217-229 pubmed publisher |
Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, et al. Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions. J Cell Biol. 2018;217:975-995 pubmed publisher |
Westrich J, Warren C, Klausner M, Guo K, Liu C, Santiago M, et al. Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. J Virol. 2018;92: pubmed publisher |
Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T. HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Oncogenesis. 2018;7:9 pubmed publisher |
Liu P, Chen M, Liu Y, Qi L, Ding S. CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Cell Stem Cell. 2018;22:252-261.e4 pubmed publisher |
Lv D, Zhang K, Li R. Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. PLoS Pathog. 2018;14:e1006868 pubmed publisher |
Alam M, Gaida M, Debnath S, Tagad H, Miller Jenkins L, Appella E, et al. Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation. PLoS Biol. 2018;16:e2004111 pubmed publisher |
van der Veen A, Maillard P, Schmidt J, Lee S, Deddouche Grass S, Borg A, et al. The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells. EMBO J. 2018;37: pubmed publisher |
Zhao G, Huang B, Rigueur D, Wang W, Bhoot C, Charles K, et al. CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance. J Bone Miner Res. 2018;33:1076-1089 pubmed publisher |
Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, et al. The protective role of DOT1L in UV-induced melanomagenesis. Nat Commun. 2018;9:259 pubmed publisher |
Xiang Q, Ju H, Li Q, Mei S, Chen D, Choi Y, et al. Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase. J Virol. 2018;92: pubmed publisher |
Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, et al. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Nat Commun. 2018;9:242 pubmed publisher |
Dopeso H, Jiao H, Cuesta A, Henze A, Jurida L, Kracht M, et al. PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα. Cancer Res. 2018;78:1805-1819 pubmed publisher |
Jiang S, Wang L, Walsh M, Trudeau S, Gerdt C, Zhao B, et al. CRISPR/Cas9-Mediated Genome Editing in Epstein-Barr Virus-Transformed Lymphoblastoid B-Cell Lines. Curr Protoc Mol Biol. 2018;121:31.12.1-31.12.23 pubmed publisher |
Adam R, Yang H, Ge Y, Lien W, Wang P, Zhao Y, et al. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression. Cell Stem Cell. 2018;22:398-413.e7 pubmed publisher |
Zhou H, Liu J, Zhou C, Gao N, Rao Z, Li H, et al. In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice. Nat Neurosci. 2018;21:440-446 pubmed publisher |
Boettcher M, Tian R, Blau J, Markegard E, Wagner R, Wu D, et al. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nat Biotechnol. 2018;36:170-178 pubmed publisher |
Steeghs E, Bakker M, Hoogkamer A, Boer J, Hartman Q, Stalpers F, et al. High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia. Sci Rep. 2018;8:693 pubmed publisher |
Damrauer J, Phelps S, Amuchastegui K, Lupo R, Mabe N, Walens A, et al. Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. Mol Cancer Res. 2018;16:599-609 pubmed publisher |
Otsuka Y, Oikawa T, Yoshino H, Hashimoto S, Handa H, Yamamoto H, et al. Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model. Cell Commun Signal. 2018;16:1 pubmed publisher |
Rider M, Cheerathodi M, Hurwitz S, Nkosi D, Howell L, Tremblay D, et al. The interactome of EBV LMP1 evaluated by proximity-based BioID approach. Virology. 2018;516:55-70 pubmed publisher |
Lee J, Kim M, Park S, Jang Y. Tousled-like kinase 1 is a negative regulator of core transcription factors in murine embryonic stem cells. Sci Rep. 2018;8:334 pubmed publisher |
Matta H, Gopalakrishnan R, Choi S, Prakash R, Natarajan V, Prins R, et al. Development and characterization of a novel luciferase based cytotoxicity assay. Sci Rep. 2018;8:199 pubmed publisher |
Zhao C, Zhang Y, Zhao Y, Ying Y, Ai R, Zhang J, et al. Multiple Chemical Inducible Tal Effectors for Genome Editing and Transcription Activation. ACS Chem Biol. 2018;13:609-617 pubmed publisher |
Roper J, Tammela T, Akkad A, Almeqdadi M, Santos S, Jacks T, et al. Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. Nat Protoc. 2018;13:217-234 pubmed publisher |
Wilkie A, Sharma M, Pesola J, Ericsson M, Fernandez R, Coen D. A Role for Myosin Va in Human Cytomegalovirus Nuclear Egress. J Virol. 2018;92: pubmed publisher |
Werley C, Chien M, Cohen A. Ultrawidefield microscope for high-speed fluorescence imaging and targeted optogenetic stimulation. Biomed Opt Express. 2017;8:5794-5813 pubmed publisher |
Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, et al. Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Oncotarget. 2017;8:106296-106310 pubmed publisher |
Pusapati G, Kong J, Patel B, Krishnan A, Sagner A, Kinnebrew M, et al. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018;44:113-129.e8 pubmed publisher |
Fenini G, Grossi S, Gehrke S, Beer H, Satoh T, Contassot E, et al. The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation. J Invest Dermatol. 2018;138:1380-1390 pubmed publisher |
Long Q, Yan R, Hu J, Cai D, Mitra B, Kim E, et al. The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. PLoS Pathog. 2017;13:e1006784 pubmed publisher |
Vijayraghavan S, Kantor B. A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells. J Vis Exp. 2017;: pubmed publisher |
Buenaventura T, Kanda N, Douzenis P, Jones B, Bloom S, Chabosseau P, et al. A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells. Diabetes. 2018;67:385-399 pubmed publisher |
Rodríguez Madoz J, San Jose Eneriz E, Rabal O, Zapata Linares N, Miranda E, Rodriguez S, et al. Reversible dual inhibitor against G9a and DNMT1 improves human iPSC derivation enhancing MET and facilitating transcription factor engagement to the genome. PLoS ONE. 2017;12:e0190275 pubmed publisher |
Nahacka Z, Svadlenka J, Peterka M, Ksandrova M, Benesova S, Neuzil J, et al. TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor. Biochim Biophys Acta Mol Cell Res. 2018;1865:522-531 pubmed publisher |
Becker J, McCarthy R, Sidoli S, Donahue G, Kaeding K, He Z, et al. Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes. Mol Cell. 2017;68:1023-1037.e15 pubmed publisher |
Labuhn M, Adams F, Ng M, Knoess S, Schambach A, Charpentier E, et al. Refined sgRNA efficacy prediction improves large- and small-scale CRISPR-Cas9 applications. Nucleic Acids Res. 2018;46:1375-1385 pubmed publisher |
Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali T, et al. Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. J Virol. 2018;92: pubmed publisher |
Namasu C, Katzerke C, Bräuer Hartmann D, Wurm A, Gerloff D, Hartmann J, et al. ABR, a novel inducer of transcription factor C/EBP?, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia. Oncotarget. 2017;8:103626-103639 pubmed publisher |
Zhou J, Zhao T, Ma L, Liang M, Guo Y, Zhao L. Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. Oncotarget. 2017;8:103167-103181 pubmed publisher |
Hamilton C, Kadeba P, Vasauskas A, Solodushko V, McClinton A, Alexeyev M, et al. Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption. Pulm Circ. 2018;8:2045893217749987 pubmed publisher |
Najm F, Strand C, Donovan K, Hegde M, Sanson K, Vaimberg E, et al. Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens. Nat Biotechnol. 2018;36:179-189 pubmed publisher |
Larabee J, Hauck G, Ballard J. Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. J Biol Chem. 2018;293:1810-1819 pubmed publisher |
Mote R, Mahajan G, Padmanabhan A, Ambati R, Subramanyam D. Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency. Sci Rep. 2017;7:17572 pubmed publisher |
Wang C, Zeng N, Liu S, Miao Q, Zhou L, Ge X, et al. Interaction of porcine reproductive and respiratory syndrome virus proteins with SUMO-conjugating enzyme reveals the SUMOylation of nucleocapsid protein. PLoS ONE. 2017;12:e0189191 pubmed publisher |
Zhang Z, Fan Y, Xie F, Zhou H, Jin K, Shao L, et al. Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7. Nat Commun. 2017;8:2116 pubmed publisher |
Macdonald R, Shrimp J, Jiang H, Zhang L, Lin H, Yen A. Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout. Sci Rep. 2017;7:17406 pubmed publisher |
Pan R, Ruvolo V, Mu H, Leverson J, Nichols G, Reed J, et al. Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy. Cancer Cell. 2017;32:748-760.e6 pubmed publisher |
Santamaria P, Floristán A, Fontanals Cirera B, Vázquez Naharro A, Santos V, Morales S, et al. Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability. Cell Death Differ. 2018;25:935-950 pubmed publisher |
Weintraub A, Li C, Zamudio A, Sigova A, Hannett N, Day D, et al. YY1 Is a Structural Regulator of Enhancer-Promoter Loops. Cell. 2017;171:1573-1588.e28 pubmed publisher |
Yau E, Rana T. Next-Generation Sequencing of Genome-Wide CRISPR Screens. Methods Mol Biol. 2018;1712:203-216 pubmed publisher |
Moretti A, Pavanelli J, Nolasco P, Leisegang M, Tanaka L, Fernandes C, et al. Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families. Sci Rep. 2017;7:17262 pubmed publisher |
Jakka P, Bhargavi B, Namani S, Murugan S, Splitter G, Radhakrishnan G. Cytoplasmic Linker Protein CLIP170 Negatively Regulates TLR4 Signaling by Targeting the TLR Adaptor Protein TIRAP. J Immunol. 2018;200:704-714 pubmed publisher |
Yu H, Jia R, Zhao L, Song S, Gu J, Zhang H. LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. Oncotarget. 2017;8:94440-94449 pubmed publisher |
Teske N, Liessem A, Fischbach F, Clarner T, Beyer C, Wruck C, et al. Chemical hypoxia-induced integrated stress response activation in oligodendrocytes is mediated by the transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF2). J Neurochem. 2018;144:285-301 pubmed publisher |
Hyun S, Sohn H, Lee H, Lee S, Kim S, Sohn D, et al. Comprehensive Analysis of Cytomegalovirus pp65 Antigen-Specific CD8+ T Cell Responses According to Human Leukocyte Antigen Class I Allotypes and Intraindividual Dominance. Front Immunol. 2017;8:1591 pubmed publisher |
Tang F, Zhang P, Ye P, Lazarski C, Wu Q, Bergin I, et al. A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice. elife. 2017;6: pubmed publisher |
Evavold C, Ruan J, Tan Y, Xia S, Wu H, Kagan J. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. 2018;48:35-44.e6 pubmed publisher |
Ginjala V, Rodriguez Colon L, Ganguly B, Gangidi P, Gallina P, Al Hraishawi H, et al. Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage. Sci Rep. 2017;7:16613 pubmed publisher |
Jafferali M, Figueroa R, Hasan M, Hallberg E. Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Sci Rep. 2017;7:16655 pubmed publisher |
Osaki T, Sivathanu V, Kamm R. Crosstalk between developing vasculature and optogenetically engineered skeletal muscle improves muscle contraction and angiogenesis. Biomaterials. 2018;156:65-76 pubmed publisher |
Duan L, Perez R, Chen L, Blatter L, Maki C. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. J Mol Cell Biol. 2018;10:331-340 pubmed publisher |
Germano G, Lamba S, Rospo G, Barault L, Magrì A, Maione F, et al. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Nature. 2017;552:116-120 pubmed publisher |
Shadrin I, Allen B, Qian Y, Jackman C, Carlson A, Juhas M, et al. Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. Nat Commun. 2017;8:1825 pubmed publisher |
Hsu W, Ma Y, Liu Y, Lee E. Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2. BMC Biol. 2017;15:112 pubmed publisher |
Norlin S, Parekh V, Edlund H. The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018;145: pubmed publisher |
Buffone A, Anderson N, Hammer D. Migration against the direction of flow is LFA-1-dependent in human hematopoietic stem and progenitor cells. J Cell Sci. 2018;131: pubmed publisher |
Sebrell T, Sidar B, Bruns R, Wilkinson R, Wiedenheft B, Taylor P, et al. Live imaging analysis of human gastric epithelial spheroids reveals spontaneous rupture, rotation and fusion events. Cell Tissue Res. 2018;371:293-307 pubmed publisher |
Taipale M. Quantitative Profiling of Chaperone/Client Interactions with LUMIER Assay. Methods Mol Biol. 2018;1709:47-58 pubmed publisher |
Ramseyer V, Kimler V, Granneman J. Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes. Mol Metab. 2018;7:57-70 pubmed publisher |
Segatto M, Fittipaldi R, Pin F, Sartori R, Dae Ko K, Zare H, et al. Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Nat Commun. 2017;8:1707 pubmed publisher |
Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, et al. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy. 2018;14:336-346 pubmed publisher |
Huang L, Lin C, Qiu J, Lin C, Hsu K, Tam K, et al. Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model. Front Cell Neurosci. 2017;11:336 pubmed publisher |
Velez D, Tsui B, Goshia T, Chute C, Han A, Carter H, et al. 3D collagen architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry. Nat Commun. 2017;8:1651 pubmed publisher |
Effenberger M, Bommert K, Kunz V, Kruk J, Leich E, Rudelius M, et al. Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation. Oncotarget. 2017;8:85858-85867 pubmed publisher |
Fontanals Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, et al. Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Mol Cell. 2017;68:731-744.e9 pubmed publisher |
Wang K, Jin Q, Ruan D, Yang Y, Liu Q, Wu H, et al. Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Genome Res. 2017;27:2061-2071 pubmed publisher |
Raffel S, Falcone M, Kneisel N, Hansson J, Wang W, Lutz C, et al. BCAT1 restricts ?KG levels in AML stem cells leading to IDHmut-like DNA hypermethylation. Nature. 2017;551:384-388 pubmed publisher |
Barrick S, Li J, Kong X, Ray A, Tajkhorshid E, Leckband D. Salt bridges gate α-catenin activation at intercellular junctions. Mol Biol Cell. 2018;29:111-122 pubmed publisher |
Girnius N, Davis R. JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Rep. 2017;21:1910-1921 pubmed publisher |
Brummer G, Acevedo D, Hu Q, Portsche M, Fang W, Yao M, et al. Chemokine Signaling Facilitates Early-Stage Breast Cancer Survival and Invasion through Fibroblast-Dependent Mechanisms. Mol Cancer Res. 2018;16:296-308 pubmed publisher |
Rhys A, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, et al. Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells. J Cell Biol. 2018;217:195-209 pubmed publisher |
Kojima R, Scheller L, Fussenegger M. Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation. Nat Chem Biol. 2018;14:42-49 pubmed publisher |
Yu X, Liang Q, Liu W, Zhou L, Li W, Liu H. Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. EBioMedicine. 2017;26:100-111 pubmed publisher |
Malty R, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, et al. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Syst. 2017;5:564-577.e12 pubmed publisher |
Du X, Cai Y, Xi W, Zhang R, Jia L, Yang A, et al. Multi?target inhibition by four tandem shRNAs embedded in homo? or hetero?miRNA backbones. Mol Med Rep. 2018;17:307-314 pubmed publisher |
Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh R, Matsuda M. Propagating Wave of ERK Activation Orients Collective Cell Migration. Dev Cell. 2017;43:305-317.e5 pubmed publisher |
Grant T, Mehta A, Gupta A, Sharif A, Arora K, Deshpande V, et al. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017;8:78556-78572 pubmed publisher |
Gurung S, Deane J, Darzi S, Werkmeister J, Gargett C. In Vivo Survival of Human Endometrial Mesenchymal Stem Cells Transplanted Under the Kidney Capsule of Immunocompromised Mice. Stem Cells Dev. 2018;27:35-43 pubmed publisher |
Brown J, Yonekubo Y, Hanson N, Sastre Perona A, Basin A, Rytlewski J, et al. TGF-β-Induced Quiescence Mediates Chemoresistance of Tumor-Propagating Cells in Squamous Cell Carcinoma. Cell Stem Cell. 2017;21:650-664.e8 pubmed publisher |
Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M. Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM. Int Immunol. 2017;29:431-438 pubmed publisher |
Hewett D, Vandyke K, Lawrence D, Friend N, Noll J, Geoghegan J, et al. DNA Barcoding Reveals Habitual Clonal Dominance of Myeloma Plasma Cells in the Bone Marrow Microenvironment. Neoplasia. 2017;19:972-981 pubmed publisher |
Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, et al. Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia. Nat Commun. 2017;8:1238 pubmed publisher |
Bollong M, Pietila M, Pearson A, Sarkar T, Ahmad I, Soundararajan R, et al. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017;114:E9903-E9912 pubmed publisher |
Cho S. APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway. Oncol Lett. 2017;14:4845-4852 pubmed publisher |
Barter M, Gomez R, Hyatt S, Cheung K, Skelton A, Xu Y, et al. The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Development. 2017;144:4510-4521 pubmed publisher |
Oh S, Kessler J. Design, Assembly, Production, and Transfection of Synthetic Modified mRNA. Methods. 2018;133:29-43 pubmed publisher |
Shpargel K, Starmer J, Wang C, Ge K, Magnuson T. UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome. Proc Natl Acad Sci U S A. 2017;114:E9046-E9055 pubmed publisher |
Rindt H, Tom C, Lorson C, Mattis V. Optimization of trans-Splicing for Huntington's Disease RNA Therapy. Front Neurosci. 2017;11:544 pubmed publisher |
Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, et al. TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Sci Signal. 2017;10: pubmed publisher |
Tan P, He L, Cui J, Qian C, Cao X, Lin M, et al. Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Mol Cell. 2017;68:293-307.e5 pubmed publisher |
Xing J, Zhang A, Zhang H, Wang J, Li X, Zeng M, et al. TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun. 2017;8:945 pubmed publisher |
Yuen G, Khan F, Gao S, Stommel J, Batchelor E, Wu X, et al. CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level. Nucleic Acids Res. 2017;45:12039-12053 pubmed publisher |
Parisi L, Li N, Atilla Gokcumen G. Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis. Cell Chem Biol. 2017;24:1445-1454.e8 pubmed publisher |
Poleshko A, Shah P, Gupta M, Babu A, Morley M, Manderfield L, et al. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. 2017;171:573-587.e14 pubmed publisher |
Gonçalves E, Fragoulis A, Garcia Alonso L, Cramer T, Saez Rodriguez J, Beltrao P. Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer. Cell Syst. 2017;5:386-398.e4 pubmed publisher |
Qiu S, Leung A, Bo Y, Kozak R, Anand S, Warkentin C, et al. Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry. Virology. 2018;513:17-28 pubmed publisher |
Cheng J, Park D, Berrios C, White E, Arora R, Yoon R, et al. Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis. PLoS Pathog. 2017;13:e1006668 pubmed publisher |
Dufrasne F, Lucchetti M, Martin A, André E, Dessilly G, Kabamba B, et al. Modulation of the NF-?B signaling pathway by the HIV-2 envelope glycoprotein and its incomplete BST-2 antagonism. Virology. 2018;513:11-16 pubmed publisher |
Paculova H, Kramara J, Simečková S, Fedr R, Soucek K, Hylse O, et al. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Tumour Biol. 2017;39:1010428317727479 pubmed publisher |
Jun I, Park H, Piao H, Han J, An M, Yun B, et al. ANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer. Br J Cancer. 2017;117:1798-1809 pubmed publisher |
Jiang S, Zhou H, Liang J, Gerdt C, Wang C, Ke L, et al. The Epstein-Barr Virus Regulome in Lymphoblastoid Cells. Cell Host Microbe. 2017;22:561-573.e4 pubmed publisher |
Chu T, Connell M, Zhou L, He Z, Won J, Chen H, et al. Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A. Mol Cancer Res. 2018;16:16-31 pubmed publisher |
Schmierer B, Botla S, Zhang J, Turunen M, Kivioja T, Taipale J. CRISPR/Cas9 screening using unique molecular identifiers. Mol Syst Biol. 2017;13:945 pubmed publisher |
Linares J, Cordes T, Duran A, Reina Campos M, Valencia T, Ahn C, et al. ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Cell Metab. 2017;26:817-829.e6 pubmed publisher |
Wang Y, Chen L, Tian Z, Shen X, Wang X, Wu H, et al. CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2. Cell Biol Int. 2018;42:187-193 pubmed publisher |
Conrad C, Götte M, Schlomann U, Roessler M, Pagenstecher A, Anderson P, et al. ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells. Int J Cancer. 2018;142:779-791 pubmed publisher |
Jiang M, Dai J, Gu D, Huang Q, Tian L. MicroRNA-7 inhibits cell proliferation of chronic myeloid leukemia and sensitizes it to imatinib in vitro. Biochem Biophys Res Commun. 2017;494:372-378 pubmed publisher |
Reddy A, Zhang J, Davis N, Moffitt A, Love C, Waldrop A, et al. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017;171:481-494.e15 pubmed publisher |
Jost M, Chen Y, Gilbert L, Horlbeck M, Krenning L, Menchon G, et al. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2017;68:210-223.e6 pubmed publisher |
Koppel I, Jaanson K, Klasche A, Tuvikene J, Tiirik T, Pärn A, et al. Dopamine cross-reacts with adrenoreceptors in cortical astrocytes to induce BDNF expression, CREB signaling and morphological transformation. Glia. 2018;66:206-216 pubmed publisher |
Lombardi M, Gillieron C, Berkelaar M, Gabay C. Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis. PLoS ONE. 2017;12:e0185426 pubmed publisher |
Cliff T, Wu T, Boward B, Yin A, Yin H, Glushka J, et al. MYC Controls Human Pluripotent Stem Cell Fate Decisions through Regulation of Metabolic Flux. Cell Stem Cell. 2017;21:502-516.e9 pubmed publisher |
Jeong H, Hernández Rodríguez B, Kim J, Kim K, Enriquez Gasca R, Yoon J, et al. Transcriptional regulation of endothelial cell behavior during sprouting angiogenesis. Nat Commun. 2017;8:726 pubmed publisher |
Yau E, Kummetha I, Lichinchi G, Tang R, Zhang Y, Rana T. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Cancer Res. 2017;77:6330-6339 pubmed publisher |
Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, et al. Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. J Immunol. 2017;199:3293-3305 pubmed publisher |
Delsin L, Roberto G, Fedatto P, Engel E, Scrideli C, Tone L, et al. Downregulated Adhesion-Associated microRNAs as Prognostic Predictors in Childhood Osteosarcoma. Pathol Oncol Res. 2019;25:11-20 pubmed publisher |
Song N, Liu Z, Xue W, Bai Z, Wang Q, Dai J, et al. NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017;68:185-197.e6 pubmed publisher |
Hubaud A, Regev I, Mahadevan L, Pourquie O. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock. Cell. 2017;171:668-682.e11 pubmed publisher |
Liang P, Ding C, Sun H, Xie X, Xu Y, Zhang X, et al. Correction of ?-thalassemia mutant by base editor in human embryos. Protein Cell. 2017;8:811-822 pubmed publisher |
Silagi E, Schoepflin Z, Seifert E, Merceron C, Schipani E, Shapiro I, et al. Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells. J Bone Miner Res. 2018;33:338-355 pubmed publisher |
Fok K, Bose R, Sheng K, Chang C, Katz Egorov M, Culty M, et al. Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Endocrinology. 2017;158:4000-4016 pubmed publisher |
Clare A, Wicky H, Empson R, Hughes S. RNA-Sequencing Analysis Reveals a Regulatory Role for Transcription Factor Fezf2 in the Mature Motor Cortex. Front Mol Neurosci. 2017;10:283 pubmed publisher |
Ramsey J, Butnor K, Peng Z, Leclair T, van der Velden J, Stein G, et al. Loss of RUNX1 is associated with aggressive lung adenocarcinomas. J Cell Physiol. 2018;233:3487-3497 pubmed publisher |
Huet Calderwood C, Rivera Molina F, Iwamoto D, Kromann E, Toomre D, Calderwood D. Novel ecto-tagged integrins reveal their trafficking in live cells. Nat Commun. 2017;8:570 pubmed publisher |
Menon M, Gropengießer J, Fischer J, Novikova L, Deuretzbacher A, Lafera J, et al. p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection. Nat Cell Biol. 2017;19:1248-1259 pubmed publisher |
Liberti M, Dai Z, Wardell S, Baccile J, Liu X, Gao X, et al. A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. Cell Metab. 2017;26:648-659.e8 pubmed publisher |
Yang M, Wei H, Wang Y, Deng J, Tang Y, Zhou L, et al. Targeted Disruption of V600E-Mutant BRAF Gene by CRISPR-Cpf1. Mol Ther Nucleic Acids. 2017;8:450-458 pubmed publisher |
Czarnek M, Bereta J. SmartFlares fail to reflect their target transcripts levels. Sci Rep. 2017;7:11682 pubmed publisher |
Cui L, Nitzsche F, Pryazhnikov E, Tibeykina M, Tolppanen L, Rytkönen J, et al. Integrin α4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection. Stroke. 2017;48:2895-2900 pubmed publisher |
Voronkova M, Luanpitpong S, Rojanasakul L, Castranova V, Dinu C, Riedel H, et al. SOX9 Regulates Cancer Stem-Like Properties and Metastatic Potential of Single-Walled Carbon Nanotube-Exposed Cells. Sci Rep. 2017;7:11653 pubmed publisher |
Dettmer U, Ramalingam N, von Saucken V, Kim T, Newman A, Terry Kantor E, et al. Loss of native ?-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017;26:3466-3481 pubmed publisher |
Fu Y, Zhang L, Zhang F, Tang T, Zhou Q, Feng C, et al. Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. PLoS Pathog. 2017;13:e1006611 pubmed publisher |
Wong K, Liu J, Chan K. KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition. Oncotarget. 2017;8:54558-54571 pubmed publisher |
Zhang Y, Kurupati R, Liu L, Zhou X, Zhang G, Hudaihed A, et al. Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017;32:377-391.e9 pubmed publisher |
Kumari P, Srinivasan B, Banerjee S. Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway. Neuroscience. 2017;364:226-241 pubmed publisher |
Abernathy D, Kim W, McCoy M, Lake A, Ouwenga R, Lee S, et al. MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell Stem Cell. 2017;21:332-348.e9 pubmed publisher |
Bellmaine S, Ovchinnikov D, Manallack D, Cuddy C, Elefanty A, Stanley E, et al. Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. elife. 2017;6: pubmed publisher |
Plessier A, LE Dret L, Varlet P, Beccaria K, Lacombe J, Mériaux S, et al. New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis. Oncotarget. 2017;8:52543-52559 pubmed publisher |
Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, et al. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature. 2017;549:399-403 pubmed publisher |
Porter J, Fisher B, Baranello L, Liu J, Kambach D, Nie Z, et al. Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response. Mol Cell. 2017;67:1013-1025.e9 pubmed publisher |
Gonçalves G, Silva D, Carvalho R, Souza B, da Silva K, Vasconcelos J, et al. Generation and characterization of transgenic mouse mesenchymal stem cell lines expressing hIGF-1 or hG-CSF. Cytotechnology. 2018;70:577-591 pubmed publisher |
Lay A, Hurcombe J, Betin V, Barrington F, Rollason R, Ni L, et al. Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor. Diabetologia. 2017;60:2299-2311 pubmed publisher |
Blazanin N, Son J, Craig Lucas A, John C, Breech K, Podolsky M, et al. ER stress and distinct outputs of the IRE1? RNase control proliferation and senescence in response to oncogenic Ras. Proc Natl Acad Sci U S A. 2017;114:9900-9905 pubmed publisher |
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher |
Liu Y, Lai S, Ma W, Ke W, Zhang C, Liu S, et al. CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. Nat Commun. 2017;8:355 pubmed publisher |
Johnson Z, Doolittle A, Snuggs J, Shapiro I, Le Maitre C, Risbud M. TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells. J Biol Chem. 2017;292:17561-17575 pubmed publisher |
Kim D, Dastidar H, Zhang C, Zemp F, Lau K, Ernst M, et al. Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms. Nat Commun. 2017;8:344 pubmed publisher |
Lyu Y, Nakano K, Davis R, Tepper C, Campbell M, Izumiya Y. ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation. J Virol. 2017;91: pubmed publisher |
Park J, Byrd A, Lee C, Morgan E. Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14α-demethylase. Biochem J. 2017;474:3241-3252 pubmed publisher |
Podlesniy P, Trullas R. Absolute measurement of gene transcripts with Selfie-digital PCR. Sci Rep. 2017;7:8328 pubmed publisher |
Pengo N, Agrotis A, Prak K, Jones J, Ketteler R. A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B. Nat Commun. 2017;8:294 pubmed publisher |
Lataniotis L, Albrecht A, Kok F, Monfries C, Benedetti L, Lawson N, et al. CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function. Sci Rep. 2017;7:8585 pubmed publisher |
Sigal M, Logan C, Kapalczynska M, Mollenkopf H, Berger H, Wiedenmann B, et al. Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017;548:451-455 pubmed publisher |
Bakke J, Wright W, Zamora A, Ong S, Wang Y, Hoyer J, et al. Transcription factor ZNF148 is a negative regulator of human muscle differentiation. Sci Rep. 2017;7:8138 pubmed publisher |
Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher |
Cracan V, Titov D, Shen H, Grabarek Z, Mootha V. A genetically encoded tool for manipulation of NADP+/NADPH in living cells. Nat Chem Biol. 2017;13:1088-1095 pubmed publisher |
Batra R, Nelles D, Pirie E, Blue S, Marina R, Wang H, et al. Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9. Cell. 2017;170:899-912.e10 pubmed publisher |
Verma D, Bajpai V, Ye N, Maneshi M, Jetta D, Andreadis S, et al. Flow induced adherens junction remodeling driven by cytoskeletal forces. Exp Cell Res. 2017;359:327-336 pubmed publisher |
Kranz P, Neumann F, Wolf A, Classen F, Pompsch M, Ocklenburg T, et al. PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR). Cell Death Dis. 2017;8:e2986 pubmed publisher |
Wanet A, Caruso M, Domelevo Entfellner J, Najar M, Fattaccioli A, Demazy C, et al. The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation. Stem Cells. 2017;35:2184-2197 pubmed publisher |
Joung J, Engreitz J, Konermann S, Abudayyeh O, Verdine V, Aguet F, et al. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Nature. 2017;548:343-346 pubmed publisher |
Tang Y, Yuwen H, Wang K, Bruno P, Bullock K, Deik A, et al. Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis. Cancer Res. 2017;77:5272-5286 pubmed publisher |
Shuptrine C, Ajina R, Fertig E, Jablonski S, Kim Lyerly H, Hartman Z, et al. An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. Cancer Immunol Immunother. 2017;66:1529-1544 pubmed publisher |
Kim S, Kwon H, Im S, Son Y, Akindehin S, Jung Y, et al. Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue. Sci Rep. 2017;7:7159 pubmed publisher |
Jacquemet G, Paatero I, Carisey A, Padzik A, Orange J, Hamidi H, et al. FiloQuant reveals increased filopodia density during breast cancer progression. J Cell Biol. 2017;216:3387-3403 pubmed publisher |
Tsherniak A, Vazquez F, Montgomery P, Weir B, Kryukov G, Cowley G, et al. Defining a Cancer Dependency Map. Cell. 2017;170:564-576.e16 pubmed publisher |
Kriebs A, Jordan S, Soto E, Henriksson E, Sandate C, Vaughan M, et al. Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. Proc Natl Acad Sci U S A. 2017;114:8776-8781 pubmed publisher |
Xiao Z, Liu J, Wang S, Zhu Y, Gao X, Tin V, et al. NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma. elife. 2017;6: pubmed publisher |
Takaki T, Montagner M, Serres M, Le Berre M, Russell M, Collinson L, et al. Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability. Nat Commun. 2017;8:16013 pubmed publisher |
Debaize L, Jakobczyk H, Rio A, Gandemer V, Troadec M. Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells: application to pre-B lymphocytes. Mol Cytogenet. 2017;10:27 pubmed publisher |
Nikolaienko O, Eriksen M, Patil S, Bito H, Bramham C. Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience. 2017;360:68-80 pubmed publisher |
Stewart A, Kendziorski G, Deak Z, Brown D, Fini M, Copely K, et al. Co-transplantation of mesenchymal and neural stem cells and overexpressing stromal-derived factor-1 for treating spinal cord injury. Brain Res. 2017;1672:91-105 pubmed publisher |
Nowicki Osuch K, Li Y, Challinor M, Gerrard D, Hanley N, Sharrocks A. EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. PLoS ONE. 2017;12:e0181902 pubmed publisher |
Pargett M, Gillies T, Teragawa C, Sparta B, Albeck J. Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors. Methods Mol Biol. 2017;1636:35-59 pubmed publisher |
Deng W, McLaughlin S, Klinke D. Quantifying spontaneous metastasis in a syngeneic mouse melanoma model using real time PCR. Analyst. 2017;142:2945-2953 pubmed publisher |
Conway D, Coon B, Budatha M, Arsenovic P, Orsenigo F, Wessel F, et al. VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Curr Biol. 2017;27:2219-2225.e5 pubmed publisher |
Loboda A, Stachurska A, Sobczak M, Podkalicka P, Mucha O, Jozkowicz A, et al. Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo. Toxicology. 2017;389:42-52 pubmed publisher |
Yuen K, Slaughter B, Gerton J. Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters. Sci Adv. 2017;3:e1700191 pubmed publisher |
Guo X, Li T, Xu Y, Xu X, Zhu Z, Zhang Y, et al. Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice. J Biol Chem. 2017;292:14003-14015 pubmed publisher |
Garzia A, Jafarnejad S, Meyer C, Chapat C, Gogakos T, Morozov P, et al. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nat Commun. 2017;8:16056 pubmed publisher |
Zhang X, Li J, Ye P, Gao G, Hubbell K, Cui X. Coculture of mesenchymal stem cells and endothelial cells enhances host tissue integration and epidermis maturation through AKT activation in gelatin methacryloyl hydrogel-based skin model. Acta Biomater. 2017;59:317-326 pubmed publisher |
Monfort D, Koria P. Recombinant elastin-based nanoparticles for targeted gene therapy. Gene Ther. 2017;24:610-620 pubmed publisher |
Viswanathan V, Ryan M, Dhruv H, Gill S, Eichhoff O, Seashore Ludlow B, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 2017;547:453-457 pubmed publisher |
Ma H, Ye W, Chen H, Nie T, Cheng L, Zhang L, et al. In-Cell Western Assays to Evaluate Hantaan Virus Replication as a Novel Approach to Screen Antiviral Molecules and Detect Neutralizing Antibody Titers. Front Cell Infect Microbiol. 2017;7:269 pubmed publisher |
Liu C, Choi H, Johnson Z, Tian J, Shapiro I, Risbud M. Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus. Sci Rep. 2017;7:4543 pubmed publisher |
Bottani E, Cerutti R, Harbour M, Ravaglia S, Doğan S, Giordano C, et al. TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III. Mol Cell. 2017;67:96-105.e4 pubmed publisher |
Feng Q, Jagannathan S, Bradley R. The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity. Mol Cell. 2017;67:239-251.e6 pubmed publisher |
Yu X, Li W, Xia Z, Xie L, Ma X, Liang Q, et al. Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis. BMC Cancer. 2017;17:449 pubmed publisher |
Benoit Y, Mitchell R, Risueno R, Orlando L, Tanasijevic B, Boyd A, et al. Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Cell Chem Biol. 2017;24:833-844.e9 pubmed publisher |
Hein L, Apaja P, Hattersley K, Grose R, Xie J, Proud C, et al. A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome. Biochim Biophys Acta Mol Cell Res. 2017;1864:1554-1565 pubmed publisher |
Li Y, Zhang Y, Wang L, Wang P, Xue Y, Li X, et al. Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia. Autophagy. 2017;13:1145-1160 pubmed publisher |
Zhang X, Jiang S, Mitok K, Li L, Attie A, Martin T. BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells. J Cell Biol. 2017;216:2151-2166 pubmed publisher |
Hori I, Otomo T, Nakashima M, Miya F, Negishi Y, Shiraishi H, et al. Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement. Sci Rep. 2017;7:3552 pubmed publisher |
Liu Q, Miller L, Blecha F, Sang Y. Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. J Gen Virol. 2017;98:1316-1328 pubmed publisher |
Hong C, Sohn H, Lee H, Cho H, Kim T. Antigen Presentation by Individually Transferred HLA Class I Genes in HLA-A, HLA-B, HLA-C Null Human Cell Line Generated Using the Multiplex CRISPR-Cas9 System. J Immunother. 2017;40:201-210 pubmed publisher |
Liu T, Jia P, Ma H, Reed S, Luo X, Larman H, et al. Construction and Screening of a Lentiviral Secretome Library. Cell Chem Biol. 2017;24:767-771.e3 pubmed publisher |
Haas T, Sciuto M, Brunetto L, Valvo C, Signore M, Fiori M, et al. Integrin ?7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma. Cell Stem Cell. 2017;21:35-50.e9 pubmed publisher |
Dreymueller D, Pruessmeyer J, Schumacher J, Fellendorf S, Hess F, Seifert A, et al. The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2017;313:L602-L614 pubmed publisher |
Ahsan M, Tchernychev B, Kessler M, Solinga R, Arthur D, Linde C, et al. Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine. Physiol Rep. 2017;5: pubmed publisher |
Seifert A, Posern G. Tightly controlled MRTF-A activity regulates epithelial differentiation during formation of mammary acini. Breast Cancer Res. 2017;19:68 pubmed publisher |
Denadai Souza A, Ribeiro C, Rolland C, Thouard A, Deraison C, Scavone C, et al. Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study. Arthritis Res Ther. 2017;19:124 pubmed publisher |
Dave K, Sur I, Yan J, Zhang J, Kaasinen E, Zhong F, et al. Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth. elife. 2017;6: pubmed publisher |
Ratsimandresy R, Chu L, Khare S, de Almeida L, Gangopadhyay A, Indramohan M, et al. The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation. Nat Commun. 2017;8:15556 pubmed publisher |
Zhang F, Zhu J, Li J, Zhu F, Zhang P. IRF2-INPP4B axis participates in the development of acute myeloid leukemia by regulating cell growth and survival. Gene. 2017;627:9-14 pubmed publisher |
Zhou S, Deng Y, Liang H, Jaoude J, Liu F. Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma. Cell Death Differ. 2017;24:1577-1587 pubmed publisher |
Mücksch F, Laketa V, Müller B, Schultz C, Kräusslich H. Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring. elife. 2017;6: pubmed publisher |
Reimer J, Knöß S, Labuhn M, Charpentier E, Göhring G, Schlegelberger B, et al. CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo. Haematologica. 2017;102:1558-1566 pubmed publisher |
Nappo G, Handle F, Santer F, McNeill R, Seed R, Collins A, et al. The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling. Oncogenesis. 2017;6:e342 pubmed publisher |
Hörl S, Ejaz A, Ernst S, Mattesich M, Kaiser A, Jenewein B, et al. CD146 (MCAM) in human cs-DLK1-/cs-CD34+ adipose stromal/progenitor cells. Stem Cell Res. 2017;22:1-12 pubmed publisher |
Yonezawa T, Takahashi H, Shikata S, Liu X, Tamura M, Asada S, et al. The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. J Biol Chem. 2017;292:12528-12541 pubmed publisher |
Yang H, Wang H, Ren J, Chen Q, Chen Z. cGAS is essential for cellular senescence. Proc Natl Acad Sci U S A. 2017;114:E4612-E4620 pubmed publisher |
Sekuła M, Domalik Pyzik P, Morawska Chochół A, Bobis Wozowicz S, Karnas E, Noga S, et al. Polylactide- and polycaprolactone-based substrates enhance angiogenic potential of human umbilical cord-derived mesenchymal stem cells in vitro - implications for cardiovascular repair. Mater Sci Eng C Mater Biol Appl. 2017;77:521-533 pubmed publisher |
Good C, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, et al. A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Nucleic Acids Res. 2017;45:8269-8281 pubmed publisher |
Yao X, Wang X, Liu J, Hu X, Shi L, Shen X, et al. CRISPR/Cas9 - Mediated Precise Targeted Integration In Vivo Using a Double Cut Donor with Short Homology Arms. EBioMedicine. 2017;20:19-26 pubmed publisher |
Wu B, McDonald A, Markham K, Rich C, McHugh K, Tatzelt J, et al. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. elife. 2017;6: pubmed publisher |
Agop Nersesian C, De Niz M, Niklaus L, Prado M, Eickel N, Heussler V. Shedding of host autophagic proteins from the parasitophorous vacuolar membrane of Plasmodium berghei. Sci Rep. 2017;7:2191 pubmed publisher |
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed publisher |
Yao X, Wang X, Hu X, Liu Z, Liu J, Zhou H, et al. Homology-mediated end joining-based targeted integration using CRISPR/Cas9. Cell Res. 2017;27:801-814 pubmed publisher |
Vanoli F, Jasin M. Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair. Methods. 2017;121-122:138-145 pubmed publisher |
Wei H, Liu Y, Wang Y, Lu Q, Yang X, Li J, et al. Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells. J Vis Exp. 2017;: pubmed publisher |
Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud P, et al. E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. JCI Insight. 2017;2: pubmed publisher |
Veß A, Blache U, Leitner L, Kurz A, Ehrenpfordt A, Sixt M, et al. A dual phenotype of MDA-MB-468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity. J Cell Sci. 2017;130:2172-2184 pubmed publisher |
Karathedath S, Rajamani B, Musheer Aalam S, Abraham A, Varatharajan S, Krishnamurthy P, et al. Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2. PLoS ONE. 2017;12:e0177227 pubmed publisher |
Choi E, Jung B, Lee S, Yoo H, Shin E, Ko H, et al. A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. Oncogene. 2017;36:5285-5295 pubmed publisher |
Zheng M, Sun W, Gao S, Luan S, Li D, Chen R, et al. Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1. Oncotarget. 2017;8:44255-44265 pubmed publisher |
Ortinski P, O Donovan B, Dong X, Kantor B. Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing. Mol Ther Methods Clin Dev. 2017;5:153-164 pubmed publisher |
Schoepflin Z, Silagi E, Shapiro I, Risbud M. PHD3 is a transcriptional coactivator of HIF-1? in nucleus pulposus cells independent of the PKM2-JMJD5 axis. FASEB J. 2017;31:3831-3847 pubmed publisher |
Ma Y, Walsh M, Bernhardt K, Ashbaugh C, Trudeau S, Ashbaugh I, et al. CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors. Cell Host Microbe. 2017;21:580-591.e7 pubmed publisher |
Hyun S, Weisberg A, Moss B. Deletion of the Vaccinia Virus I2 Protein Interrupts Virion Morphogenesis, Leading to Retention of the Scaffold Protein and Mislocalization of Membrane-Associated Entry Proteins. J Virol. 2017;91: pubmed publisher |
Decalf J, Desdouits M, Rodrigues V, Gobert F, Gentili M, Marques Ladeira S, et al. Sensing of HIV-1 Entry Triggers a Type I Interferon Response in Human Primary Macrophages. J Virol. 2017;91: pubmed publisher |
Liu Y, Zhang Z, Liang H, Zhao X, Liang L, Wang G, et al. Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression. Sci Rep. 2017;7:1630 pubmed publisher |
Chapat C, Jafarnejad S, Matta Camacho E, Hesketh G, Gelbart I, Attig J, et al. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proc Natl Acad Sci U S A. 2017;114:5425-5430 pubmed publisher |
Xia L, Huang W, Bellani M, Seidman M, Wu K, Fan D, et al. CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell. 2017;31:653-668.e7 pubmed publisher |
Li Q, Ni R, Hong H, Goh K, Rossi M, Fast V, et al. Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression. Sci Rep. 2017;7:1531 pubmed publisher |
van Wijk S, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, et al. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-?B and restricts bacterial proliferation. Nat Microbiol. 2017;2:17066 pubmed publisher |
Baumgart S, Najafova Z, Hossan T, Xie W, Nagarajan S, Kari V, et al. CHD1 regulates cell fate determination by activation of differentiation-induced genes. Nucleic Acids Res. 2017;45:7722-7735 pubmed publisher |
Lin M, Cheng X, Tammineni P, Xie Y, Zhou B, Cai Q, et al. Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Neuron. 2017;94:595-610.e6 pubmed publisher |
Ernandez T, Komarynets O, Chassot A, Sougoumarin S, Soulie P, Wang Y, et al. Primary cilia control the maturation of tubular lumen in renal collecting duct epithelium. Am J Physiol Cell Physiol. 2017;313:C94-C107 pubmed publisher |
Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd J, et al. Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension. Mol Biol Cell. 2017;28:1177-1185 pubmed publisher |
Pryke K, Abraham J, Sali T, Gall B, Archer I, Liu A, et al. A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio. 2017;8: pubmed publisher |
Monge C, DiStasio N, Rossi T, Sébastien M, Sakai H, Kalman B, et al. Quiescence of human muscle stem cells is favored by culture on natural biopolymeric films. Stem Cell Res Ther. 2017;8:104 pubmed publisher |
Lee G, Kim H. JNK-associated scattered growth of YD-10B oral squamous carcinoma cells while maintaining the epithelial phenotype. Biochem Biophys Res Commun. 2017;487:862-867 pubmed publisher |
Lupey Green L, Moquin S, Martin K, McDevitt S, Hulse M, Caruso L, et al. PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter. Virology. 2017;507:220-230 pubmed publisher |
Li Y, Asfour H, Bursac N. Age-dependent functional crosstalk between cardiac fibroblasts and cardiomyocytes in a 3D engineered cardiac tissue. Acta Biomater. 2017;55:120-130 pubmed publisher |
Rohrbach T, Jones R, Hicks P, Weaver A, Cooper T, Eustace N, et al. MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines. Oncol Lett. 2017;13:1216-1222 pubmed publisher |
Gentle I, McHenry K, Weber A, Metz A, Kretz O, Porter D, et al. TIR-domain-containing adapter-inducing interferon-β (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. FEBS J. 2017;284:1987-2003 pubmed publisher |
Zhang P, Rausch C, Hastert F, Boneva B, Filatova A, Patil S, et al. Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. Nucleic Acids Res. 2017;45:7118-7136 pubmed publisher |
Strezoska Z, Perkett M, Chou E, Maksimova E, Anderson E, McClelland S, et al. High-content analysis screening for cell cycle regulators using arrayed synthetic crRNA libraries. J Biotechnol. 2017;251:189-200 pubmed publisher |
Pelaseyed T, Viswanatha R, Sauvanet C, Filter J, Goldberg M, Bretscher A. Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism. elife. 2017;6: pubmed publisher |
Wang H, Tian L, Goldstein A, Liu J, Lo H, Sheng K, et al. Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Nat Commun. 2017;8:15045 pubmed publisher |
Lee C, Tripathi S, Morgan E. Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system. Free Radic Biol Med. 2017;108:478-486 pubmed publisher |
Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, et al. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017;14:629-635 pubmed publisher |
Xie S, Duan J, Li B, Zhou P, Hon G. Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells. Mol Cell. 2017;66:285-299.e5 pubmed publisher |
Yang H, Adam R, Ge Y, Hua Z, Fuchs E. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. Cell. 2017;169:483-496.e13 pubmed publisher |
Chirieleison S, Marsh R, Kumar P, Rathkey J, Dubyak G, Abbott D. Nucleotide-binding oligomerization domain (NOD) signaling defects and cell death susceptibility cannot be uncoupled in X-linked inhibitor of apoptosis (XIAP)-driven inflammatory disease. J Biol Chem. 2017;292:9666-9679 pubmed publisher |
Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, et al. Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia. Cancer Cell. 2017;31:549-562.e11 pubmed publisher |
Bharathan S, Nandy K, Palani D, Janet A N, Natarajan K, George B, et al. Generation of an induced pluripotent stem cell line that mimics the disease phenotypes from a patient with Fanconi anemia by conditional complementation. Stem Cell Res. 2017;20:54-57 pubmed publisher |
Zhang X, Zhu C, Wang T, Jiang H, Ren Y, Zhang Q, et al. GP73 represses host innate immune response to promote virus replication by facilitating MAVS and TRAF6 degradation. PLoS Pathog. 2017;13:e1006321 pubmed publisher |
Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher |
Guan R, Zhang L, Su Q, Mickolajczyk K, Chen G, Hancock W, et al. Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin. Nat Commun. 2017;8:14951 pubmed publisher |
Taabazuing C, Okondo M, Bachovchin D. Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages. Cell Chem Biol. 2017;24:507-514.e4 pubmed publisher |
Morita S, Villalta S, Feldman H, Register A, Rosenthal W, Hoffmann Petersen I, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017;25:883-897.e8 pubmed publisher |
Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, et al. FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch. Sci Rep. 2017;7:46021 pubmed publisher |
Takayama K, Matsuura A, Itakura E. Dissection of ubiquitinated protein degradation by basal autophagy. FEBS Lett. 2017;591:1199-1211 pubmed publisher |
Klann T, Black J, Chellappan M, Safi A, Song L, Hilton I, et al. CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome. Nat Biotechnol. 2017;35:561-568 pubmed publisher |
Kolli N, Lu M, Maiti P, Rossignol J, Dunbar G. CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease. Int J Mol Sci. 2017;18: pubmed publisher |
Lu X, Bai D, Liu X, Zhou C, Yang G. Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation. Sci Rep. 2017;7:45648 pubmed publisher |
Dasgupta N, Thakur B, Ta A, Das S, Banik G, Das S. Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein ? to mediate colon carcinoma cell differentiation and apoptosis. Biochim Biophys Acta Gen Subj. 2017;1861:1777-1787 pubmed publisher |
Taylor M, Husain K, Gartner Z, Mayor S, Vale R. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017;169:108-119.e20 pubmed publisher |
Su X, Liu S, Zhang X, Lam S, Hu X, Zhou Y, et al. Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:692-705 pubmed publisher |
Werley C, Chien M, Gaublomme J, Shekhar K, Butty V, Yi B, et al. Geometry-dependent functional changes in iPSC-derived cardiomyocytes probed by functional imaging and RNA sequencing. PLoS ONE. 2017;12:e0172671 pubmed publisher |
Joung J, Konermann S, Gootenberg J, Abudayyeh O, Platt R, Brigham M, et al. Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat Protoc. 2017;12:828-863 pubmed publisher |
Talbot N, Sparks W, Phillips C, Ealy A, Powell A, Caperna T, et al. Bovine trophectoderm cells induced from bovine fibroblasts with induced pluripotent stem cell reprogramming factors. Mol Reprod Dev. 2017;84:468-485 pubmed publisher |
Ma W, Lee O, Kim H, Songyang Z. Using Protein-Fragment Complementation Assays (PCA) and Peptide Arrays to Study Telomeric Protein-Protein Interactions. Methods Mol Biol. 2017;1587:147-160 pubmed publisher |
Souza B, Silva D, Carvalho R, Sampaio G, Paredes B, Aragão França L, et al. Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy. Am J Pathol. 2017;187:1134-1146 pubmed publisher |
Ota K, Tong K, Goto K, Tomida S, Komuro A, Wang Z, et al. The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner. PLoS ONE. 2017;12:e0173713 pubmed publisher |
Lin J, Gu C, Shen Z, Liu Y, Wang W, Tao S, et al. Hepatocyte nuclear factor 1α downregulates HBV gene expression and replication by activating the NF-κB signaling pathway. PLoS ONE. 2017;12:e0174017 pubmed publisher |
Zhang C, Jiang H, Wang P, Liu H, Sun X. Transcription factor NF-kappa B represses ANT1 transcription and leads to mitochondrial dysfunctions. Sci Rep. 2017;7:44708 pubmed publisher |
Ejaz A, Mattesich M, Zwerschke W. Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells. Aging (Albany NY). 2017;9:860-879 pubmed publisher |
Zhang X, Tu R, Li K, Ye P, Cui X. Tumor Suppressor PTPRJ Is a Target of miR-155 in Colorectal Cancer. J Cell Biochem. 2017;118:3391-3400 pubmed publisher |
del Amo C, Borau C, Movilla N, Asín J, Garcia Aznar J. Quantifying 3D chemotaxis in microfluidic-based chips with step gradients of collagen hydrogel concentrations. Integr Biol (Camb). 2017;9:339-349 pubmed publisher |
Yamaji M, Jishage M, Meyer C, Suryawanshi H, Der E, Yamaji M, et al. DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs. Nature. 2017;543:568-572 pubmed publisher |
Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, et al. ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Nat Commun. 2017;8:14714 pubmed publisher |
CAROMILE L, Dortche K, Rahman M, Grant C, Stoddard C, Ferrer F, et al. PSMA redirects cell survival signaling from the MAPK to the PI3K-AKT pathways to promote the progression of prostate cancer. Sci Signal. 2017;10: pubmed publisher |
Zhang W, Lohman A, Zhuravlova Y, Lu X, Wiens M, Hoi H, et al. Optogenetic control with a photocleavable protein, PhoCl. Nat Methods. 2017;14:391-394 pubmed publisher |
Petit M, Koziel R, Etemad S, Pircher H, Jansen Durr P. Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells. Exp Gerontol. 2017;92:7-12 pubmed publisher |
Li Z, Bi Y, Xiao H, Sun L, Ren Y, Li Y, et al. CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes. Virus Res. 2018;244:286-295 pubmed publisher |
Yamasaki T, Hoyos Ramirez E, Martenson J, Morimoto Tomita M, Tomita S. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Neuron. 2017;93:1138-1152.e6 pubmed publisher |
Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017;13:e1006658 pubmed publisher |
Lee J, Snyder E, Liu Y, Gu X, Wang J, Flowers B, et al. Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Nat Commun. 2017;8:14686 pubmed publisher |
Guo X, Wu N, Shang Y, Wu T, Zhou Y, Liu X, et al. The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells. Front Immunol. 2017;8:158 pubmed publisher |
Bierie B, Pierce S, Kroeger C, Stover D, Pattabiraman D, Thiru P, et al. Integrin-?4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Proc Natl Acad Sci U S A. 2017;114:E2337-E2346 pubmed publisher |
Carter B, Mak P, Wang X, Yang H, Garcia Manero G, Mak D, et al. Focal Adhesion Kinase as a Potential Target in AML and MDS. Mol Cancer Ther. 2017;16:1133-1144 pubmed publisher |
Ahmad F, Singh K, Das D, Gowaikar R, Shaw E, Ramachandran A, et al. Reactive Oxygen Species-Mediated Loss of Synaptic Akt1 Signaling Leads to Deficient Activity-Dependent Protein Translation Early in Alzheimer's Disease. Antioxid Redox Signal. 2017;27:1269-1280 pubmed publisher |
Terzuoli E, Finetti F, Costanza F, Giachetti A, Ziche M, Donnini S. Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells. Nitric Oxide. 2017;66:17-29 pubmed publisher |
Liu W, Chen H, Wong N, Haynes W, Baker C, Wang X. Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. Cancer Lett. 2017;394:65-75 pubmed publisher |
Qiu H, Zhong J, Luo L, Tang Z, Liu N, Kang K, et al. Regulatory Axis of miR-195/497 and HMGA1-Id3 Governs Muscle Cell Proliferation and Differentiation. Int J Biol Sci. 2017;13:157-166 pubmed publisher |
Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann A, et al. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proc Natl Acad Sci U S A. 2017;114:E2243-E2252 pubmed publisher |
Karakikes I, Termglinchan V, Cepeda D, Lee J, Diecke S, Hendel A, et al. A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases. Circ Res. 2017;120:1561-1571 pubmed publisher |
Schimmack G, Schorpp K, Kutzner K, Gehring T, Brenke J, Hadian K, et al. YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB. elife. 2017;6: pubmed publisher |
Huang X, Zhou G, Wu W, Ma G, D Amore P, Mukai S, et al. Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation. Invest Ophthalmol Vis Sci. 2017;58:1228-1236 pubmed publisher |
Tuncay E, Bitirim V, Durak A, Carrat G, Taylor K, Rutter G, et al. Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Diabetes. 2017;66:1346-1358 pubmed publisher |
Cai Y, Tsai H, Yen R, Zhang Y, Kong X, Wang W, et al. Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells. Genome Res. 2017;27:533-544 pubmed publisher |
Okerlund N, Schneider K, Leal Ortiz S, Montenegro Venegas C, Kim S, Garner L, et al. Bassoon Controls Presynaptic Autophagy through Atg5. Neuron. 2017;93:897-913.e7 pubmed publisher |
Kuwajima T, Soares C, Sitko A, Lefebvre V, Mason C. SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. Neuron. 2017;93:1110-1125.e5 pubmed publisher |
GarcÃa Tuñón I, Hernández Sánchez M, Ordoñez J, Alonso Pérez V, Ãlamo Quijada M, Benito R, et al. The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia. Oncotarget. 2017;8:26027-26040 pubmed publisher |
Shats I, Deng M, Davidovich A, Zhang C, Kwon J, Manandhar D, et al. Expression level is a key determinant of E2F1-mediated cell fate. Cell Death Differ. 2017;24:626-637 pubmed publisher |
Bianco C, Mohr I. Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing. J Virol. 2017;91: pubmed publisher |
Shah M, Cardenas R, Wang B, Persson J, Mongan N, Grabowska A, et al. HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells. Mol Cancer. 2017;16:38 pubmed publisher |
Chung F, Tan P, Raja V, Tan B, Lim K, Kam T, et al. Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1). Sci Rep. 2017;7:42504 pubmed publisher |
Gong H, Liu M, Klomp J, Merrill B, Rehman J, Malik A. Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells. Sci Rep. 2017;7:42127 pubmed publisher |
Daks A, Petukhov A, Fedorova O, Shuvalov O, Merkulov V, Vasileva E, et al. E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells. Genes Cancer. 2016;7:383-393 pubmed publisher |
Dong L, Yuan Y, Opansky C, Chen Y, Aguilera Barrantes I, Wu S, et al. Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. Oncotarget. 2017;8:22550-22562 pubmed publisher |
Tao C, Hsu W, Ma Y, Cheng S, Lee E. Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease. Cell Death Differ. 2017;24:597-614 pubmed publisher |
Leoni C, Montagner S, Rinaldi A, Bertoni F, Polletti S, Balestrieri C, et al. Dnmt3a restrains mast cell inflammatory responses. Proc Natl Acad Sci U S A. 2017;114:E1490-E1499 pubmed publisher |
El Fatimy R, Subramanian S, Uhlmann E, Krichevsky A. Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. Mol Ther. 2017;25:368-378 pubmed publisher |
Duhachek Muggy S, Qi Y, Wise R, Alyahya L, Li H, Hodge J, et al. Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer. Mol Cancer. 2017;16:32 pubmed publisher |
Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, et al. Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Res. 2017;27:483-504 pubmed publisher |
Franco Barraza J, Francescone R, Luong T, Shah N, Madhani R, Cukierman G, et al. Matrix-regulated integrin ?v?5 maintains ?5?1-dependent desmoplastic traits prognostic of neoplastic recurrence. elife. 2017;6: pubmed publisher |
Demetriadou A, Morales Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate E, et al. Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. J Cell Sci. 2017;130:903-915 pubmed publisher |
Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester Beltrán J, et al. Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest. 2017;127:814-829 pubmed publisher |
Lawson H, Zayed M, Wayhart J, Fabbrini E, Love Gregory L, Klein S, et al. Physiologic and genetic evidence links hemopexin to triglycerides in mice and humans. Int J Obes (Lond). 2017;41:631-638 pubmed publisher |
Heffernan C, Jain M, Liu T, Kim H, Barretto K, Li H, et al. Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis in Vitro. J Biol Chem. 2017;292:4484-4498 pubmed publisher |
Donovan K, Hegde M, Sullender M, Vaimberg E, Johannessen C, Root D, et al. Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool. PLoS ONE. 2017;12:e0170445 pubmed publisher |
Golden R, Chen B, Li T, Braun J, Manjunath H, Chen X, et al. An Argonaute phosphorylation cycle promotes microRNA-mediated silencing. Nature. 2017;542:197-202 pubmed publisher |
Jansen S, Kress E, Fragoulis A, Wruck C, Wolf R, Grötzinger J, et al. Psoriasin has divergent effects on the innate immune responses of murine glial cells. J Neurochem. 2017;141:86-99 pubmed publisher |
Zhang C, Mukherjee S, Tucker Burden C, Ross J, Chau M, Kong J, et al. TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Mol Oncol. 2017;11:280-294 pubmed publisher |
Socodato R, Santiago F, Portugal C, Domith I, Encarnação T, Loiola E, et al. Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation. Sci Rep. 2017;7:40912 pubmed publisher |
Bharathan S, Manian K, Aalam S, Palani D, Deshpande P, Pratheesh M, et al. Systematic evaluation of markers used for the identification of human induced pluripotent stem cells. Biol Open. 2017;6:100-108 pubmed publisher |
Alvarado A, Thiagarajan P, Mulkearns Hubert E, Silver D, Hale J, Alban T, et al. Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression. Cell Stem Cell. 2017;20:450-461.e4 pubmed publisher |
Sun A, Wei J, Childress C, Shaw J, Peng K, Shao G, et al. The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy. Autophagy. 2017;13:522-537 pubmed publisher |
Min J, Wright W, Shay J. Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Res. 2017;45:2615-2628 pubmed publisher |
Sendoel A, Dunn J, Rodriguez E, Naik S, Gomez N, Hurwitz B, et al. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017;541:494-499 pubmed publisher |
Sansregret L, Patterson J, Dewhurst S, Lopez Garcia C, Koch A, McGranahan N, et al. APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. Cancer Discov. 2017;7:218-233 pubmed publisher |
Cağlayan M, Horton J, Dai D, Stefanick D, Wilson S. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nat Commun. 2017;8:14045 pubmed publisher |
Best H, Neverman N, Wicky H, Mitchell N, Leitch B, Hughes S. Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics. Neurobiol Dis. 2017;100:62-74 pubmed publisher |
Heitzig N, Brinkmann B, Koerdt S, Rosso G, Shahin V, Rescher U. Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Cell Adh Migr. 2017;11:275-287 pubmed publisher |
Daniel M, Pereira C, Bernitz J, Lemischka I, Moore K. Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program. J Vis Exp. 2016;: pubmed publisher |
Liu T, Yao Y, Zhang G, Wang Y, Deng B, Song J, et al. A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis. Oncotarget. 2017;8:16728-16743 pubmed publisher |
Wang Q, Liberti M, Liu P, Deng X, Liu Y, Locasale J, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017;24:55-65 pubmed publisher |
van den Berg D, Azzarelli R, Oishi K, Martynoga B, Urbán N, Dekkers D, et al. Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. Neuron. 2017;93:348-361 pubmed publisher |
Myung J, Yeo S, Kim K, Baek K, Shin D, Kim J, et al. Proteins that interact with calgranulin B in the human colon cancer cell line HCT-116. Oncotarget. 2017;8:6819-6832 pubmed publisher |
Araujo T, Zeidler J, Oliveira P, Dias M, Armelin H, Laurindo F. Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes. Free Radic Biol Med. 2017;103:199-208 pubmed publisher |
Wei Y, Chiang W, Sumpter R, Mishra P, Levine B. Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. Cell. 2017;168:224-238.e10 pubmed publisher |
Souza B, Sampaio G, Pereira C, Campos G, Sardi S, Freitas L, et al. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Sci Rep. 2016;6:39775 pubmed publisher |
Schaefer P, von Einem B, Walther P, Calzia E, von Arnim C. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration. PLoS ONE. 2016;11:e0168157 pubmed publisher |
Draheim K, Huet Calderwood C, Simon B, Calderwood D. Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences ?1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus. J Biol Chem. 2017;292:1884-1898 pubmed publisher |
Kim H, Song M, Lee J, Menon A, Jung S, Kang Y, et al. In vivo high-throughput profiling of CRISPR-Cpf1 activity. Nat Methods. 2017;14:153-159 pubmed publisher |
Dixit A, Parnas O, Li B, Chen J, Fulco C, Jerby Arnon L, et al. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016;167:1853-1866.e17 pubmed publisher |
Fettweis G, Di Valentin E, L homme L, Lassence C, Dequiedt F, Fillet M, et al. RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Biochim Biophys Acta Mol Cell Res. 2017;1864:113-124 pubmed publisher |
Hurwitz S, Nkosi D, Conlon M, York S, Liu X, Tremblay D, et al. CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling. J Virol. 2017;91: pubmed publisher |
Garcia B, Merayo Lloves J, Rodriguez D, Alcalde I, Garcia Suarez O, Alfonso J, et al. Different Use of Cell Surface Glycosaminoglycans As Adherence Receptors to Corneal Cells by Gram Positive and Gram Negative Pathogens. Front Cell Infect Microbiol. 2016;6:173 pubmed |
Koc E, Miller Lee J, Koc H. Fyn kinase regulates translation in mammalian mitochondria. Biochim Biophys Acta Gen Subj. 2017;1861:533-540 pubmed publisher |
Shen Q, Cheng F, Song H, Lu W, Zhao J, An X, et al. Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes. Am J Hum Genet. 2017;100:5-20 pubmed publisher |
Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X, Shi H, et al. EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect. Oncotarget. 2017;8:9557-9571 pubmed publisher |
Jaafar L, Li Z, Li S, Dynan W. SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining. Nucleic Acids Res. 2017;45:1848-1859 pubmed publisher |
Nagai Y, Kikuchi E, Lerchner W, Inoue K, Ji B, Eldridge M, et al. PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nat Commun. 2016;7:13605 pubmed publisher |
Faes S, Duval A, Planche A, Uldry E, Santoro T, Pythoud C, et al. Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. Mol Cancer. 2016;15:78 pubmed |
Eshtad S, Mavajian Z, Rudd S, Visnes T, Bostrom J, Altun M, et al. hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Oncogenesis. 2016;5:e275 pubmed publisher |
Cao J, Tyburczy M, Moss J, Darling T, Widlund H, Kwiatkowski D. Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. J Clin Invest. 2017;127:349-364 pubmed publisher |
Wada S, Neinast M, Jang C, Ibrahim Y, Lee G, Babu A, et al. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 2016;30:2551-2564 pubmed |
Desai M, Slusarczyk A, Chapin A, Barch M, Jasanoff A. Molecular imaging with engineered physiology. Nat Commun. 2016;7:13607 pubmed publisher |
Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, et al. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608 pubmed publisher |
Sano T, Kobayashi T, Negoro H, Sengiku A, Hiratsuka T, Kamioka Y, et al. Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. Physiol Rep. 2016;4: pubmed |
Xu D, Du Q, Han C, Wang Z, Zhang X, Wang T, et al. p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Vet Res. 2016;47:120 pubmed |
Bavin E, Atkinson F, Barsby T, Guest D. Scleraxis Is Essential for Tendon Differentiation by Equine Embryonic Stem Cells and in Equine Fetal Tenocytes. Stem Cells Dev. 2017;26:441-450 pubmed publisher |
Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, et al. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition. Cell Stem Cell. 2017;20:191-204.e5 pubmed publisher |
Berrios C, Padi M, Keibler M, Park D, Molla V, Cheng J, et al. Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016;12:e1006020 pubmed publisher |
Johnson Z, Shapiro I, Risbud M. RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE?. J Biol Chem. 2016;291:26686-26697 pubmed publisher |
Weischenfeldt J, Dubash T, Drainas A, Mardin B, Chen Y, Stütz A, et al. Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Nat Genet. 2017;49:65-74 pubmed publisher |
Lee B, Lee T, Shim J. Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane. Biochim Biophys Acta Mol Cell Res. 2017;1864:303-313 pubmed publisher |
Perez Diaz S, García Rodríguez B, Gonzalez Irazabal Y, Valero M, Lagos Lizan J, Arbones Mainar J. Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. Am J Physiol Cell Physiol. 2017;312:C83-C91 pubmed publisher |
Lopez Mosqueda J, Maddi K, Prgomet S, Kalayil S, Marinovic Terzic I, Terzic J, et al. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. elife. 2016;5: pubmed publisher |
Lorendeau D, Rinaldi G, Boon R, Spincemaille P, Metzger K, Jäger C, et al. Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Metab Eng. 2017;43:187-197 pubmed publisher |
Chromá K, Mistrik M, Moudry P, Gursky J, Liptay M, Strauss R, et al. Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress. Oncogene. 2017;36:2405-2422 pubmed publisher |
Vallejo DÃaz J, Olazabal Morán M, Cariaga MartÃnez A, Pajares M, Flores J, Pio R, et al. Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma. Oncotarget. 2016;7:85063-85078 pubmed publisher |
Misra A, Green M. Fluorescence Reporter-Based Genome-Wide RNA Interference Screening to Identify Alternative Splicing Regulators. Methods Mol Biol. 2017;1507:1-12 pubmed |
Han H, Liang X, Ekberg M, Kritikou J, Brunnström A, Pelcman B, et al. Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation. FASEB J. 2017;31:491-504 pubmed publisher |
Kaminski M, Tosic J, Kresbach C, Engel H, Klockenbusch J, Müller A, et al. Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nat Cell Biol. 2016;18:1269-1280 pubmed publisher |
Kitazawa K, Hikichi T, Nakamura T, Sotozono C, Kinoshita S, Masui S. PAX6 regulates human corneal epithelium cell identity. Exp Eye Res. 2017;154:30-38 pubmed publisher |
Brunger J, Zutshi A, Willard V, Gersbach C, Guilak F. CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues. Arthritis Rheumatol. 2017;69:1111-1121 pubmed publisher |
Wang J, Qiao L, Hou Z, Luo G. TIM-1 Promotes Hepatitis C Virus Cell Attachment and Infection. J Virol. 2017;91: pubmed publisher |
Mallarino R, Henegar C, Mirasierra M, Manceau M, Schradin C, Vallejo M, et al. Developmental mechanisms of stripe patterns in rodents. Nature. 2016;539:518-523 pubmed publisher |
Lang J, Young R, Ashraf H, Canty J. Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro. PLoS ONE. 2016;11:e0165926 pubmed publisher |
Lin N, Huang Y, Opal P, Goldman R, Messing A, Perng M. The role of gigaxonin in the degradation of the glial-specific intermediate filament protein GFAP. Mol Biol Cell. 2016;27:3980-3990 pubmed |
Cuff A, Robertson F, Stegmann K, Pallett L, Maini M, Davidson B, et al. Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation. J Immunol. 2016;197:4283-4291 pubmed |
Boehm E, Zornoza M, Jourdain A, Delmiro Magdalena A, Garcia Consuegra I, Torres Merino R, et al. Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. J Biol Chem. 2016;291:25877-25887 pubmed |
Lin Y, Mori E, Kato M, Xiang S, Wu L, Kwon I, et al. Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. Cell. 2016;167:789-802.e12 pubmed publisher |
Zhang R, Yang J, Peng L, Zheng L, Xie P, Wang M, et al. RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA. Cell Cycle. 2016;15:3094-3104 pubmed |
Gantner M, Hazen B, Eury E, Brown E, Kralli A. Complementary Roles of Estrogen-Related Receptors in Brown Adipocyte Thermogenic Function. Endocrinology. 2016;157:4770-4781 pubmed |
Won H, de la Torre Ubieta L, Stein J, Parikshak N, Huang J, Opland C, et al. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature. 2016;538:523-527 pubmed publisher |
Nokin M, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, et al. Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. elife. 2016;5: pubmed publisher |
Wein M, Liang Y, Göransson O, Sundberg T, Wang J, Williams E, et al. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016;7:13176 pubmed publisher |
Dufrasne F, Lombard C, Goubau P, Ruelle J. Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism. Viruses. 2016;8: pubmed |
Hanč P, Schulz O, Fischbach H, Martin S, Kjær S, Reis E Sousa C. A pH- and ionic strength-dependent conformational change in the neck region regulates DNGR-1 function in dendritic cells. EMBO J. 2016;35:2484-2497 pubmed |
Nguyen H, Kirkton R, Bursac N. Engineering prokaryotic channels for control of mammalian tissue excitability. Nat Commun. 2016;7:13132 pubmed publisher |
Ni T, Li X, Lu N, An T, Liu Z, Fu R, et al. Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Nat Cell Biol. 2016;18:1221-1232 pubmed publisher |
Geiger R, Rieckmann J, Wolf T, Basso C, Feng Y, Fuhrer T, et al. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell. 2016;167:829-842.e13 pubmed publisher |
Xu J, Zhu W, Guo Y, Jiang C, Hussain N, Meng L, et al. Construction of Conveniently Screening pLKO.1-TRC Vector Tagged with TurboGFP. Appl Biochem Biotechnol. 2017;181:699-709 pubmed publisher |
Malaise O, Relic B, Charlier E, Zeddou M, Neuville S, Deroyer C, et al. Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Arthritis Res Ther. 2016;18:219 pubmed |
Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan S, et al. mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease. Alzheimers Dement. 2017;13:152-167 pubmed publisher |
Zheng L, Yang J, Cao Y, Peng L, Sun R, Xie P, et al. SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. Cancer Res. 2017;77:579-589 pubmed publisher |
Fromer M, Roussos P, Sieberts S, Johnson J, Kavanagh D, Perumal T, et al. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nat Neurosci. 2016;19:1442-1453 pubmed publisher |
Park S, Choi M, Park D, Jeong M, Ahn K, Lee J, et al. AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells. Oncol Rep. 2016;36:2641-2646 pubmed publisher |
Pecze L, Blum W, Henzi T, Schwaller B. Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations. Biochim Biophys Acta. 2016;1863:2905-2915 pubmed publisher |
Beldi Ferchiou A, Lambert M, Dogniaux S, Vély F, Vivier E, Olive D, et al. PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma. Oncotarget. 2016;7:72961-72977 pubmed publisher |
Chen M, Kim H, Jagot Lacoussiere L, Maurel P. Cadm3 (Necl-1) interferes with the activation of the PI3 kinase/Akt signaling cascade and inhibits Schwann cell myelination in vitro. Glia. 2016;64:2247-2262 pubmed publisher |
Carr R, Qiao G, Qin J, Jayaraman S, Prabhakar B, Maker A. Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis. Cell Death Discov. 2016;2:16067 pubmed publisher |
Ahani R, Roohvand F, Cohan R, Etemadzadeh M, Mohajel N, Behdani M, et al. Sindbis Virus-Pseudotyped Lentiviral Vectors Carrying VEGFR2-Specific Nanobody for Potential Transductional Targeting of Tumor Vasculature. Mol Biotechnol. 2016;58:738-747 pubmed |
Bergeman J, Caillier A, Houle F, Gagné L, Huot M. Localized translation regulates cell adhesion and transendothelial migration. J Cell Sci. 2016;129:4105-4117 pubmed |
Vernia S, Edwards Y, Han M, Cavanagh Kyros J, Barrett T, Kim J, et al. An alternative splicing program promotes adipose tissue thermogenesis. elife. 2016;5: pubmed publisher |
Dogra S, Kumar A, Umrao D, Sahasrabuddhe A, Yadav P. Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression. Sci Rep. 2016;6:33401 pubmed publisher |
Li H, Su Y, Zhang Y, Liu Z, Hua B. Involvement of peroxisome proliferator activated receptor-? in the anti-inflammatory effects of atorvastatin in oxygen-glucose deprivation/reperfusion-stimulated RAW264.7 murine macrophages. Mol Med Rep. 2016;14:4055-4062 pubmed publisher |
Iempridee T. Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines. Exp Biol Med (Maywood). 2017;242:184-193 pubmed publisher |
Perkhofer L, Walter K, Costa I, Carrasco M, Eiseler T, Hafner S, et al. Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness. Stem Cell Res. 2016;17:367-378 pubmed publisher |
Tan X, Thapa N, Liao Y, Choi S, Anderson R. PtdIns(4,5)P2 signaling regulates ATG14 and autophagy. Proc Natl Acad Sci U S A. 2016;113:10896-901 pubmed publisher |
Li H, Gumbiner B. Deregulation of the Hippo pathway in mouse mammary stem cells promotes mammary tumorigenesis. Mamm Genome. 2016;27:556-564 pubmed |
Huggins I, Brafman D, Willert K. Methods to Manipulate and Monitor Wnt Signaling in Human Pluripotent Stem Cells. Methods Mol Biol. 2016;1481:161-81 pubmed publisher |
Petrova Y, Schecterson L, Gumbiner B. Roles for E-cadherin cell surface regulation in cancer. Mol Biol Cell. 2016;27:3233-3244 pubmed |
Ma L, Roderick J, Kelliher M, Green M. High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML. Methods Mol Biol. 2016;1465:159-73 pubmed publisher |
Sturgill E, Malouli D, Hansen S, Burwitz B, Seo S, Schneider C, et al. Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus. PLoS Pathog. 2016;12:e1005868 pubmed publisher |
Wu R, Nie Q, Tapper E, Jerde C, Dunlap G, Shrestha S, et al. Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter. Cancer Res. 2016;76:6362-6373 pubmed |
Arakawa H. A method to convert mRNA into a gRNA library for CRISPR/Cas9 editing of any organism. Sci Adv. 2016;2:e1600699 pubmed publisher |
Shekhar K, Lapan S, Whitney I, Tran N, Macosko E, Kowalczyk M, et al. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016;166:1308-1323.e30 pubmed publisher |
Zhang X, Chen M, Wu X, Kodani A, Fan J, Doan R, et al. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016;166:1147-1162.e15 pubmed publisher |
Wilkie A, Lawler J, Coen D. A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. MBio. 2016;7: pubmed publisher |
Walker K, HJELMELAND A. Method for Efficient Transduction of Cancer Stem Cells. J Cancer Stem Cell Res. 2014;2: pubmed |
Ali M, Devkota S, Roh J, Lee J, Lee H. Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1. Biochem Biophys Res Commun. 2016;478:1198-204 pubmed publisher |
Wu J, Wang J, Zeng X, Chen Y, Xia J, Wang S, et al. Protein phosphatase 2A regulatory subunit B56? modulates erythroid differentiation. Biochem Biophys Res Commun. 2016;478:1179-84 pubmed publisher |
García Aguilar A, Guillen C, Nellist M, Bartolomé A, Benito M. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy. Biochim Biophys Acta. 2016;1863:2658-2667 pubmed publisher |
Li J, Yu H, Xi M, Lu X. Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer. J Ovarian Res. 2016;9:49 pubmed publisher |
Hastie E, Cataldi M, Moerdyk Schauwecker M, Felt S, Steuerwald N, Grdzelishvili V. Novel biomarkers of resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus. Oncotarget. 2016;7:61601-61618 pubmed publisher |
Salloum S, Holmes J, Jindal R, Bale S, Brisac C, Alatrakchi N, et al. Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types. Hepatology. 2016;64:1951-1968 pubmed publisher |
Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, et al. BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. J Biol Chem. 2016;291:21616-21629 pubmed |
Kaminski R, Chen Y, Salkind J, Bella R, Young W, Ferrante P, et al. Negative Feedback Regulation of HIV-1 by Gene Editing Strategy. Sci Rep. 2016;6:31527 pubmed publisher |
Beg M, Srivastava A, Shankar K, Varshney S, Rajan S, Gupta A, et al. PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance. Mol Cell Endocrinol. 2016;437:97-107 pubmed publisher |
Deguchi Y, Okabe H, Oshima N, Hisamori S, Minamiguchi S, Muto M, et al. PTEN loss is associated with a poor response to trastuzumab in HER2-overexpressing gastroesophageal adenocarcinoma. Gastric Cancer. 2017;20:416-427 pubmed publisher |
Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, et al. MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production. J Innate Immun. 2016;8:564-578 pubmed |
La Porta J, Matus Nicodemos R, Valentin Acevedo A, Covey L. The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation. PLoS ONE. 2016;11:e0158708 pubmed publisher |
Kim M, Kim D, Kim E, Kim C. CXCR4 Overexpression in Human Adipose Tissue-Derived Stem Cells Improves Homing and Engraftment in an Animal Limb Ischemia Model. Cell Transplant. 2017;26:191-204 pubmed publisher |
Kubaczka C, Schorle H. Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells. J Vis Exp. 2016;: pubmed publisher |
Uzel S, Platt R, Subramanian V, Pearl T, Rowlands C, Chan V, et al. Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units. Sci Adv. 2016;2:e1501429 pubmed publisher |
Lai M, Gonzalez Martin A, Cooper A, Oda H, Jin H, Shepherd J, et al. Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs. Nat Commun. 2016;7:12207 pubmed publisher |
Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed publisher |
Ma G, Duan Y, Huang X, Qian C, Chee Y, Mukai S, et al. Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Invest Ophthalmol Vis Sci. 2016;57:3935-43 pubmed publisher |
Feng G, Tong M, Xia B, Luo G, Wang M, Xie D, et al. Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. EMBO Rep. 2016;17:1304-13 pubmed publisher |
Brinkmann B, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, et al. VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol Biol Cell. 2016;27:2811-21 pubmed publisher |
Chun M, Kim S, Hwang S, Kim B, Kim H, Choi H, et al. AMP-activated protein kinase is involved in the activation of the Fanconi anemia/BRCA pathway in response to DNA interstrand crosslinks. Oncotarget. 2016;7:53642-53653 pubmed publisher |
Poddar S, Hyde J, Gorman M, Farzan M, Diamond M. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. J Virol. 2016;90:8780-94 pubmed publisher |
Martin K, Lupey L, Tempera I. Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. J Virol. 2016;90:8520-30 pubmed publisher |
Lambrus B, Daggubati V, Uetake Y, Scott P, Clutario K, Sluder G, et al. A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. J Cell Biol. 2016;214:143-53 pubmed publisher |
Snapkov I, Oqvist C, Figenschau Y, Kogner P, Johnsen J, Sveinbjørnsson B. The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis. BMC Cancer. 2016;16:490 pubmed publisher |
Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed |
Hurwitz S, Conlon M, Rider M, Brownstein N, Meckes D. Nanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis. J Extracell Vesicles. 2016;5:31295 pubmed publisher |
Udommethaporn S, Tencomnao T, McGowan E, Boonyaratanakornkit V. Assessment of Anti-TNF-? Activities in Keratinocytes Expressing Inducible TNF- ?: A Novel Tool for Anti-TNF-? Drug Screening. PLoS ONE. 2016;11:e0159151 pubmed publisher |
Chidley C, Trauger S, Birsoy K, O Shea E. The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine. elife. 2016;5: pubmed publisher |
Liang C, Xu Y, Zheng D, Sun X, Xu Q, Duan D. RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats. J Neuroimmunol. 2016;297:28-37 pubmed publisher |
Harwardt T, Lukas S, Zenger M, Reitberger T, Danzer D, Übner T, et al. Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response. PLoS Pathog. 2016;12:e1005748 pubmed publisher |
Chen G, Gong R, Shi X, Yang D, Zhang G, Lu A, et al. Halofuginone and artemisinin synergistically arrest cancer cells at the G1/G0 phase by upregulating p21Cip1 and p27Kip1. Oncotarget. 2016;7:50302-50314 pubmed publisher |
Gorman M, Poddar S, Farzan M, Diamond M. The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. J Virol. 2016;90:8212-25 pubmed publisher |
Ye X, Zhou M, He Y, Wan Y, Bai W, Tao S, et al. Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide. Sci Rep. 2016;6:29391 pubmed publisher |
Coelho Santos V, Socodato R, Portugal C, Leitão R, Rito M, Barbosa M, et al. Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells. Cell Mol Life Sci. 2016;73:4701-4716 pubmed |
Proff J, Walterskirchen C, Brey C, Geyeregger R, Full F, Ensser A, et al. Cytomegalovirus-Infected Cells Resist T Cell Mediated Killing in an HLA-Recognition Independent Manner. Front Microbiol. 2016;7:844 pubmed publisher |
Mohammadzadeh A, Pourfathollah A, Shahrokhi S, Fallah A, Tahoori M, Amari A, et al. Evaluation of AD-MSC (adipose-derived mesenchymal stem cells) as a vehicle for IFN-? delivery in experimental autoimmune encephalomyelitis. Clin Immunol. 2016;169:98-106 pubmed publisher |
McDade J, Waxmonsky N, Swanson L, Fan M. Practical Considerations for Using Pooled Lentiviral CRISPR Libraries. Curr Protoc Mol Biol. 2016;115:31.5.1-31.5.13 pubmed publisher |
Lee J, Heckl D, Parekkadan B. Multiple genetically engineered humanized microenvironments in a single mouse. Biomater Res. 2016;20:19 pubmed publisher |
Yang J, Shen Z, Jiang X, Yang H, Huang H, Jin L, et al. Agonist-Activated Bombyx Corazonin Receptor Is Internalized via an Arrestin-Dependent and Clathrin-Independent Pathway. Biochemistry. 2016;55:3874-87 pubmed publisher |
Zhang Q, Yan H, Wang J, Cui S, Wang X, Jiang Y, et al. Chromatin remodeling gene AT-rich interactive domain-containing protein 1A suppresses gastric cancer cell proliferation by targeting PIK3CA and PDK1. Oncotarget. 2016;7:46127-46141 pubmed publisher |
Dan A, Huang R, Leckband D. Dynamic Imaging Reveals Coordinate Effects of Cyclic Stretch and Substrate Stiffness on Endothelial Integrity. Ann Biomed Eng. 2016;44:3655-3667 pubmed |
Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, et al. MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Cell Death Differ. 2016;23:1658-69 pubmed publisher |
Choi H, Merceron C, Mangiavini L, Seifert E, Schipani E, Shapiro I, et al. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016;12:1631-46 pubmed publisher |
Shang Y, Wang H, Jia P, Zhao H, Liu C, Liu W, et al. Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy. 2016;12:1575-92 pubmed publisher |
Comenge J, Fragueiro O, Sharkey J, Taylor A, Held M, Burton N, et al. Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo. ACS Nano. 2016;10:7106-16 pubmed publisher |
Lin J, He S, Sun X, Franck G, Deng Y, Yang D, et al. MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. FASEB J. 2016;30:3216-26 pubmed publisher |
Wang Y, Sun S, Liu Q, Yu Y, Guo J, Wang K, et al. Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression. Cancer Discov. 2016;6:1022-35 pubmed publisher |
Dasgupta N, Thakur B, Ta A, Dutta P, Das S. Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation. J Cell Biochem. 2017;118:191-203 pubmed publisher |
Hwang P, Jing L, Chen J, Lim F, Tang R, Choi H, et al. N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. Sci Rep. 2016;6:28038 pubmed publisher |
Schenk L, Schulze U, Henke S, Weide T, Pavenstadt H. TMEM16F Regulates Baseline Phosphatidylserine Exposure and Cell Viability in Human Embryonic Kidney Cells. Cell Physiol Biochem. 2016;38:2452-63 pubmed publisher |
Cai H, Yao W, Li L, Li X, Hu L, Mai R, et al. Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A. Sci Rep. 2016;6:27778 pubmed publisher |
Tu S, Narendra V, Yamaji M, Vidal S, Rojas L, Wang X, et al. Co-repressor CBFA2T2 regulates pluripotency and germline development. Nature. 2016;534:387-90 pubmed publisher |
Chen X, Rinsma M, Janssen J, Liu J, Maggio I, Gonçalves M. Probing the impact of chromatin conformation on genome editing tools. Nucleic Acids Res. 2016;44:6482-92 pubmed publisher |
Piya S, Kornblau S, Ruvolo V, Mu H, Ruvolo P, McQueen T, et al. Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia. Blood. 2016;128:1260-9 pubmed publisher |
Wu L, Sun Y, Ma L, Zhu J, Zhang B, Pan Q, et al. A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum. Sci Rep. 2016;6:27332 pubmed publisher |
Yi H, Zeng D, Shen Z, Liao J, Wang X, Liu Y, et al. Integrin alphavbeta3 enhances ?-catenin signaling in acute myeloid leukemia harboring Fms-like tyrosine kinase-3 internal tandem duplication mutations: implications for microenvironment influence on sorafenib sensitivity. Oncotarget. 2016;7:40387-40397 pubmed publisher |
Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, et al. Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. PLoS Pathog. 2016;12:e1005655 pubmed publisher |
Gerin I, Ury B, Breloy I, Bouchet Seraphin C, Bolsée J, Halbout M, et al. ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan. Nat Commun. 2016;7:11534 pubmed publisher |
Han T, Goralski M, Capota E, Padrick S, Kim J, Xie Y, et al. The antitumor toxin CD437 is a direct inhibitor of DNA polymerase ?. Nat Chem Biol. 2016;12:511-5 pubmed publisher |
Park S, Choi J, Biering S, Dominici E, Williams L, Hwang S. Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Autophagy. 2016;12:1153-67 pubmed publisher |
LeNoue Newton M, Wadzinski B, Spiller B. The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4. Biochem Biophys Res Commun. 2016;475:64-9 pubmed publisher |
Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, et al. TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Rep. 2016;15:1566-1579 pubmed publisher |
Jadav R, Kumar D, Buwa N, Ganguli S, Thampatty S, Balasubramanian N, et al. Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Cell Signal. 2016;28:1124-36 pubmed publisher |
Spadafora D, Kozhukhar N, Chouljenko V, Kousoulas K, Alexeyev M. Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells. PLoS ONE. 2016;11:e0154684 pubmed publisher |
Beard J, Tenga A, Hills J, Hoyer J, Cherian M, Wang Y, et al. The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Sci Rep. 2016;6:25108 pubmed publisher |
Zhao Z, Lee R, Pusapati G, Iyu A, Rohatgi R, Ingham P. An essential role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO Rep. 2016;17:739-52 pubmed publisher |
Zhang Y, Huang Y, Jin Z, Li X, Li B, Xu P, et al. A convenient and effective strategy for the enrichment of tumor-initiating cell properties in prostate cancer cells. Tumour Biol. 2016;37:11973-11981 pubmed |
Lipinski K, Britschgi C, Schrader K, Christinat Y, Frischknecht L, Krek W. Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1. Oncotarget. 2016;7:29635-47 pubmed publisher |
Zakikhan K, Pournasr B, Nassiri Asl M, Baharvand H. Enhanced direct conversion of fibroblasts into hepatocyte-like cells by Kdm2b. Biochem Biophys Res Commun. 2016;474:97-103 pubmed publisher |
Dauber B, Poon D, Dos Santos T, Duguay B, Mehta N, Saffran H, et al. The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. J Virol. 2016;90:6049-6057 pubmed publisher |
Walia M, Ho P, Taylor S, Ng A, Gupte A, Chalk A, et al. Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance. elife. 2016;5: pubmed publisher |
Rider M, Hurwitz S, Meckes D. ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles. Sci Rep. 2016;6:23978 pubmed publisher |
Villacorte M, Delmarcelle A, Lernoux M, Bouquet M, Lemoine P, Bolsée J, et al. Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016;143:1958-70 pubmed publisher |
Moreau T, Evans A, Vasquez L, Tijssen M, Yan Y, Trotter M, et al. Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming. Nat Commun. 2016;7:11208 pubmed publisher |
Suyama K, Silagi E, Choi H, Sakabe K, Mochida J, Shapiro I, et al. Circadian factors BMAL1 and ROR? control HIF-1? transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget. 2016;7:23056-71 pubmed publisher |
Wang Z, Ji J, Peng D, Ma F, Cheng G, Qin F. Complex Regulation Pattern of IRF3 Activation Revealed by a Novel Dimerization Reporter System. J Immunol. 2016;196:4322-30 pubmed publisher |
Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, et al. P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. J Cell Biol. 2016;213:81-95 pubmed publisher |
Jo S, Lee Y, Kim S, Lee H, Chung H. PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Biochim Biophys Acta. 2016;1863:1499-509 pubmed publisher |
Li C, Jiang W, Hu Q, Li L, Dong L, Chen R, et al. Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis. Oncotarget. 2016;7:22893-910 pubmed publisher |
Leng C, Zhang Z, Chen W, Luo H, Song J, Dong W, et al. An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK-AKT pathway. Cancer Lett. 2016;376:188-96 pubmed publisher |
Ma L, Bian S, Cui J, Xi H, Zhang K, Qin H, et al. LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and β-catenin. Int J Mol Med. 2016;37:1039-48 pubmed publisher |
Alotaibi M, Sharma K, Saleh T, Povirk L, Hendrickson E, Gewirtz D. Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Radiat Res. 2016;185:229-45 pubmed publisher |
Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, et al. The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proc Natl Acad Sci U S A. 2016;113:3054-9 pubmed publisher |
Takaku M, Grimm S, Shimbo T, Perera L, Menafra R, Stunnenberg H, et al. GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler. Genome Biol. 2016;17:36 pubmed publisher |
Lu Y, Galbraith L, Herndon J, Lü Y, Pras Raves M, Vervaart M, et al. Defining functional classes of Barth syndrome mutation in humans. Hum Mol Genet. 2016;25:1754-70 pubmed publisher |
McGuire A, Gray M, Dosenovic P, Gitlin A, Freund N, Petersen J, et al. Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice. Nat Commun. 2016;7:10618 pubmed publisher |
Kawprasertsri S, Pietras R, Marquez Garban D, Boonyaratanakornkit V. Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Cancer Lett. 2016;374:279-91 pubmed publisher |
Arbi M, Pefani D, Kyrousi C, Lalioti M, Kalogeropoulou A, Papanastasiou A, et al. GemC1 controls multiciliogenesis in the airway epithelium. EMBO Rep. 2016;17:400-13 pubmed publisher |
Prior K, Wittig I, Leisegang M, Groenendyk J, Weissmann N, Michalak M, et al. The Endoplasmic Reticulum Chaperone Calnexin Is a NADPH Oxidase NOX4 Interacting Protein. J Biol Chem. 2016;291:7045-59 pubmed publisher |
Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior I, et al. Feedback activation of neurofibromin terminates growth factor-induced Ras activation. Cell Commun Signal. 2016;14:5 pubmed publisher |
Hashimoto S, Mikami S, Sugino H, Yoshikawa A, Hashimoto A, Onodera Y, et al. Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Nat Commun. 2016;7:10656 pubmed publisher |
Peixoto P, Blomme A, Costanza B, Ronca R, Rezzola S, Palacios A, et al. HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. Oncogene. 2016;35:4481-94 pubmed publisher |
Maiden S, Petrova Y, Gumbiner B. Microtubules Inhibit E-Cadherin Adhesive Activity by Maintaining Phosphorylated p120-Catenin in a Colon Carcinoma Cell Model. PLoS ONE. 2016;11:e0148574 pubmed publisher |
Tai D, Liu Y, Hsu W, Ma Y, Cheng S, Liu S, et al. MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome. Nat Commun. 2016;7:10552 pubmed publisher |
Tenga A, Beard J, Takwi A, Wang Y, Chen T. Regulation of Nuclear Receptor Nur77 by miR-124. PLoS ONE. 2016;11:e0148433 pubmed publisher |
Leung A, Murdoch B, Salem A, Prasad M, Gomez G, GarcÃa Castro M. WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate. Development. 2016;143:398-410 pubmed publisher |
Nakajo A, Yoshimura S, Togawa H, Kunii M, Iwano T, Izumi A, et al. EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. J Cell Biol. 2016;212:297-306 pubmed publisher |
Puujalka E, Heinz M, Hoesel B, Friedl P, Schweighofer B, Wenzina J, et al. Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma. J Invest Dermatol. 2016;136:967-977 pubmed publisher |
Lai X, Ye L, Liao Y, Jin L, Ma Q, Lu B, et al. Agonist-induced activation of histamine H3 receptor signals to extracellular signal-regulated kinases 1 and 2 through PKC-, PLD-, and EGFR-dependent mechanisms. J Neurochem. 2016;137:200-15 pubmed publisher |
Bondy Chorney E, Crawford Parks T, Ravel Chapuis A, Klinck R, Rocheleau L, Pelchat M, et al. Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier. PLoS Genet. 2016;12:e1005827 pubmed publisher |
Bi R, Tang J, Zhang W, Li X, Chen S, Yu D, et al. Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia. Schizophr Res. 2016;171:200-6 pubmed publisher |
Martina J, Diab H, Brady O, Puertollano R. TFEB and TFE3 are novel components of the integrated stress response. EMBO J. 2016;35:479-95 pubmed publisher |
Schätzle P, Kapitein L, Hoogenraad C. Live imaging of microtubule dynamics in organotypic hippocampal slice cultures. Methods Cell Biol. 2016;131:107-26 pubmed publisher |
Doench J, Fusi N, Sullender M, Hegde M, Vaimberg E, Donovan K, et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nat Biotechnol. 2016;34:184-191 pubmed publisher |
Bognar M, Vincendeau M, Erdmann T, Seeholzer T, Grau M, Linnemann J, et al. Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas. Oncogene. 2016;35:4269-81 pubmed publisher |
Hsiao C, Lampe M, Nillasithanukroh S, Han W, Lian X, Palecek S. Human pluripotent stem cell culture density modulates YAP signaling. Biotechnol J. 2016;11:662-75 pubmed publisher |
Rollason R, Wherlock M, Heath J, Heesom K, Saleem M, Welsh G. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2. Biosci Rep. 2016;36:e00302 pubmed publisher |
Maggio I, Stefanucci L, Janssen J, Liu J, Chen X, Mouly V, et al. Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations. Nucleic Acids Res. 2016;44:1449-70 pubmed publisher |
Priglinger C, Obermann J, Szober C, Merl Pham J, Ohmayer U, Behler J, et al. Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased β1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding. PLoS ONE. 2016;11:e0146887 pubmed publisher |
Lalli M, Jang J, Park J, Wang Y, Guzman E, Zhou H, et al. Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways. Hum Mol Genet. 2016;25:1294-306 pubmed publisher |
Pauerstein P, Park K, Peiris H, Wang J, Kim S. Research Resource: Genetic Labeling of Human Islet Alpha Cells. Mol Endocrinol. 2016;30:248-53 pubmed publisher |
Wang X, Tang Z, Yu D, Cui S, Jiang Y, Zhang Q, et al. Epithelial but not stromal expression of collagen alpha-1(III) is a diagnostic and prognostic indicator of colorectal carcinoma. Oncotarget. 2016;7:8823-38 pubmed publisher |
Vincendeau M, Hadian K, Messias A, Brenke J, Hålander J, Griesbach R, et al. Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Sci Rep. 2016;6:18934 pubmed publisher |
Lange S, Tomida J, Boulware K, Bhetawal S, Wood R. The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability. PLoS Genet. 2016;12:e1005759 pubmed publisher |
Yuen K, Xu B, Krantz I, Gerton J. NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Cell Rep. 2016;14:93-102 pubmed publisher |
Raab J, Resnick S, Magnuson T. Genome-Wide Transcriptional Regulation Mediated by Biochemically Distinct SWI/SNF Complexes. PLoS Genet. 2015;11:e1005748 pubmed publisher |
Han Z, Bart S, Ruthel G, Vande Burgt N, Haines K, Volk S, et al. Ebola virus mediated infectivity is restricted in canine and feline cells. Vet Microbiol. 2016;182:102-7 pubmed publisher |
Ferré C, Davezac N, Thouard A, Peyrin J, Belenguer P, Miquel M, et al. Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. FASEB J. 2016;30:1523-33 pubmed publisher |
Wang Q, Sun Y, Ren Y, Gao Y, Tian L, Liu Y, et al. Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury. Neural Plast. 2015;2015:249756 pubmed publisher |
Klingenstein M, Raab S, Achberger K, Kleger A, Liebau S, Linta L. TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Stem Cells Int. 2016;2016:6759343 pubmed publisher |
He J, Huang L, Qiu H, Li J, Luo L, Li Y, et al. A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency. Cell Biosci. 2015;5:67 pubmed publisher |
Sali T, Pryke K, Abraham J, Liu A, Archer I, Broeckel R, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015;11:e1005324 pubmed publisher |
Balázs A, Németh B, Ördög B, Hegyi E, Hritz I, Czakó L, et al. A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort. Pancreas. 2016;45:541-5 pubmed publisher |
Morris V, Cummings C, Korb B, Boaglio S, Oehler V. Deregulated KLF4 Expression in Myeloid Leukemias Alters Cell Proliferation and Differentiation through MicroRNA and Gene Targets. Mol Cell Biol. 2016;36:559-73 pubmed publisher |
Kessler M, Hoffmann K, Brinkmann V, Thieck O, Jackisch S, Toelle B, et al. The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids. Nat Commun. 2015;6:8989 pubmed publisher |
Helferich A, Ruf W, Grozdanov V, Freischmidt A, Feiler M, Zondler L, et al. α-synuclein interacts with SOD1 and promotes its oligomerization. Mol Neurodegener. 2015;10:66 pubmed publisher |
Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, et al. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015;6:10068 pubmed publisher |
Qiu H, Zhong J, Luo L, Liu N, Kang K, Qu J, et al. A PCR-Based Method to Construct Lentiviral Vector Expressing Double Tough Decoy for miRNA Inhibition. PLoS ONE. 2015;10:e0143864 pubmed publisher |
Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, et al. Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression. Cancer Discov. 2016;6:430-45 pubmed publisher |
Wanzel M, Vischedyk J, Gittler M, Gremke N, Seiz J, Hefter M, et al. CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol. 2016;12:22-8 pubmed publisher |
Yang H, Schramek D, Adam R, Keyes B, Wang P, Zheng D, et al. ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. elife. 2015;4:e10870 pubmed publisher |
Ma L, Cui J, Xi H, Bian S, Wei B, Chen L. Fat4 suppression induces Yap translocation accounting for the promoted proliferation and migration of gastric cancer cells. Cancer Biol Ther. 2016;17:36-47 pubmed publisher |
Baskin J, Wu X, Christiano R, Oh M, Schauder C, Gazzerro E, et al. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat Cell Biol. 2016;18:132-8 pubmed publisher |
Nagel D, Bognar M, Eitelhuber A, Kutzner K, Vincendeau M, Krappmann D. Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma. Oncotarget. 2015;6:42232-42 pubmed publisher |
Wu Z, Zhang Z, Ge X, Lin Y, Dai C, Chang J, et al. Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. Oncotarget. 2015;6:40519-34 pubmed publisher |
Kapoor I, Kanaujiya J, Kumar Y, Thota J, Bhatt M, Chattopadhyay N, et al. Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation. Oncotarget. 2016;7:7640-56 pubmed publisher |
Thakore P, D Ippolito A, Song L, Safi A, Shivakumar N, Kabadi A, et al. Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements. Nat Methods. 2015;12:1143-9 pubmed publisher |
Aparicio Prat E, Arnan C, Sala I, Bosch N, Guigó R, Johnson R. DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs. BMC Genomics. 2015;16:846 pubmed publisher |
Habiger C, Jäger G, Walter M, Iftner T, Stubenrauch F. Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. J Virol. 2016;90:694-704 pubmed publisher |
Bralha F, Liyanage S, Hurren R, Wang X, Son M, Fung T, et al. Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Oncotarget. 2015;6:37216-28 pubmed publisher |
Rohrbach T, Shah N, Jackson W, Feeney E, Scanlon S, Gish R, et al. The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization. PLoS ONE. 2015;10:e0140870 pubmed publisher |
Klanova M, Andera L, Brazina J, Svadlenka J, Benesova S, Soukup J, et al. Targeting of BCL2 Family Proteins with ABT-199 and Homoharringtonine Reveals BCL2- and MCL1-Dependent Subgroups of Diffuse Large B-Cell Lymphoma. Clin Cancer Res. 2016;22:1138-49 pubmed publisher |
Lee J, Tang S, Ortiz V, Vo T, Fruman D. MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma. Oncotarget. 2015;6:35202-17 pubmed publisher |
Tan Y, Alkhamees B, Jia D, Li L, Couture J, Figeys D, et al. MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation. Stem Cell Reports. 2015;5:741-52 pubmed publisher |
Piroli G, Manuel A, Clapper A, Walla M, Baatz J, Palmiter R, et al. Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Mol Cell Proteomics. 2016;15:445-61 pubmed publisher |
Nawandar D, Wang A, Makielski K, Lee D, Ma S, Barlow E, et al. Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PLoS Pathog. 2015;11:e1005195 pubmed publisher |
Chen Y, Gou X, Kong D, Wang X, Wang J, Chen Z, et al. EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF. Oncotarget. 2015;6:32575-85 pubmed publisher |
Kubaczka C, Senner C, Cierlitza M, Araúzo Bravo M, Kuckenberg P, Peitz M, et al. Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts. Cell Stem Cell. 2015;17:557-68 pubmed publisher |
Li J, Di C, Jing J, Di Q, Nakhla J, Adamson D. OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways. Int J Oncol. 2015;47:1703-10 pubmed publisher |
Pecze L, Blum W, Schwaller B. Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. J Biol Chem. 2015;290:28214-30 pubmed publisher |
Richner M, Victor M, Liu Y, Abernathy D, Yoo A. MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons. Nat Protoc. 2015;10:1543-55 pubmed publisher |
Chapard C, Hohl D, Huber M. The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis. Oncotarget. 2015;6:20933-45 pubmed |
Schnerch D, Nigg E. Structural centrosome aberrations favor proliferation by abrogating microtubule-dependent tissue integrity of breast epithelial mammospheres. Oncogene. 2016;35:2711-22 pubmed publisher |
Wollebo H, Bellizzi A, Kaminski R, Hu W, White M, Khalili K. CRISPR/Cas9 System as an Agent for Eliminating Polyomavirus JC Infection. PLoS ONE. 2015;10:e0136046 pubmed publisher |
Duan L, Perez R, Davaadelger B, Dedkova E, Blatter L, Maki C. p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget. 2015;6:23135-56 pubmed |
Maris P, Blomme A, Palacios A, Costanza B, Bellahcène A, Bianchi E, et al. Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Med. 2015;12:e1001871 pubmed publisher |
Beckta J, Dever S, Gnawali N, Khalil A, Sule A, Golding S, et al. Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget. 2015;6:27674-87 pubmed publisher |
Hirai H, Firpo M, Kikyo N. Derivation of LIF-independent mouse iPS cells with modified Oct4. Stem Cell Res. 2015;15:384-6 pubmed publisher |
Rad A, Farshchian M, Forghanifard M, Matin M, Bahrami A, Geerts D, et al. Predicting the molecular role of MEIS1 in esophageal squamous cell carcinoma. Tumour Biol. 2016;37:1715-25 pubmed publisher |
Peters E, Christoforou N, Moore E, West J, Truskey G. CD45+ Cells Present Within Mesenchymal Stem Cell Populations Affect Network Formation of Blood-Derived Endothelial Outgrowth Cells. Biores Open Access. 2015;4:75-88 pubmed publisher |
Tuncay H, Brinkmann B, Steinbacher T, Schürmann A, Gerke V, Iden S, et al. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015;6:8128 pubmed publisher |
Simmons A, Alberola Ila J. Retroviral Transduction of T Cells and T Cell Precursors. Methods Mol Biol. 2016;1323:99-108 pubmed publisher |
Komatsubara A, Matsuda M, Aoki K. Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer. Sci Rep. 2015;5:13283 pubmed publisher |
Haghpanah V, Fallah P, Tavakoli R, Naderi M, Samimi H, Soleimani M, et al. Antisense-miR-21 enhances differentiation/apoptosis and reduces cancer stemness state on anaplastic thyroid cancer. Tumour Biol. 2016;37:1299-308 pubmed publisher |
Archibald A, Al Masri M, Liew Spilger A, McCaffrey L. Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Mol Biol Cell. 2015;26:3578-95 pubmed publisher |
Voon Y, Ahmad M, Wong P, Husaini R, Ng W, Leong C, et al. Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. Oncol Rep. 2015;34:1692-700 pubmed publisher |
Barger C, Zhang W, Hillman J, Stablewski A, Higgins M, Vanderhyden B, et al. Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression. Oncotarget. 2015;6:27613-27 pubmed publisher |
Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek S, et al. α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal. Stem Cell Reports. 2015;5:195-206 pubmed publisher |
Kim N, Gumbiner B. Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway. J Cell Biol. 2015;210:503-15 pubmed publisher |
Trinh B, Barengo N, Kim S, Lee J, Zweidler McKay P, Naora H. The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling. J Cell Sci. 2015;128:3055-67 pubmed publisher |
Kruse C, Kurz A, Pálfi K, Humbert P, Sperandio M, Brandes R, et al. Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling. Arterioscler Thromb Vasc Biol. 2015;35:1954-62 pubmed publisher |
Penzo Méndez A, Chen Y, Li J, Witze E, Stanger B. Spontaneous Cell Competition in Immortalized Mammalian Cell Lines. PLoS ONE. 2015;10:e0132437 pubmed publisher |
Parnas O, Jovanovic M, Eisenhaure T, Herbst R, Dixit A, Ye C, et al. A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Cell. 2015;162:675-86 pubmed publisher |
Pereira S, Moss D, Williams S, Murray P, Taylor A. Overexpression of the MRI Reporter Genes Ferritin and Transferrin Receptor Affect Iron Homeostasis and Produce Limited Contrast in Mesenchymal Stem Cells. Int J Mol Sci. 2015;16:15481-96 pubmed publisher |
Bjørklund S, Kristensen V, Seiler M, Kumar S, Alnæs G, Ming Y, et al. Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas. BMC Cancer. 2015;15:524 pubmed publisher |
Tan B, Tiong K, Choo H, Chung F, Hii L, Tan S, et al. Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). Cell Death Dis. 2015;6:e1826 pubmed publisher |
Song C, Wang J, Mo C, Mu S, Jiang X, Li X, et al. Use of Ferritin Expression, Regulated by Neural Cell-Specific Promoters in Human Adipose Tissue-Derived Mesenchymal Stem Cells, to Monitor Differentiation with Magnetic Resonance Imaging In Vitro. PLoS ONE. 2015;10:e0132480 pubmed publisher |
Lubick K, Robertson S, McNally K, Freedman B, Rasmussen A, Taylor R, et al. Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression. Cell Host Microbe. 2015;18:61-74 pubmed publisher |
Rodrigues A, Guerreiro M, Formas Oliveira A, Fernandes P, Blechert A, Genzel Y, et al. Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK. Biotechnol Bioeng. 2016;113:150-62 pubmed publisher |
Yin J, Park G, Lee J, Choi E, Park J, Kim T, et al. DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. Brain. 2015;138:2553-70 pubmed publisher |
Thompson K, Marquez S, Lu L, Reisman D. Induction of functional Brm protein from Brm knockout mice. Oncoscience. 2015;2:349-61 pubmed |
Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev A. Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance. J Biol Chem. 2015;290:19218-32 pubmed publisher |
Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed publisher |
Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, et al. Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. EMBO Mol Med. 2015;7:1048-62 pubmed publisher |
van Lessen M, Nakayama M, Kato K, Kim J, Kaibuchi K, Adams R. Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like. Arterioscler Thromb Vasc Biol. 2015;35:1815-25 pubmed publisher |
Amente S, Milazzo G, Sorrentino M, Ambrosio S, Di Palo G, Lania L, et al. Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Oncotarget. 2015;6:14572-83 pubmed |
Cheng J, Li W, Kang B, Zhou Y, Song J, Dan S, et al. Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat Commun. 2015;6:7209 pubmed publisher |
Unni A, Lockwood W, Zejnullahu K, Lee Lin S, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. elife. 2015;4:e06907 pubmed publisher |
Belian E, Noseda M, Abreu Paiva M, Leja T, Sampson R, Schneider M. Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. PLoS ONE. 2015;10:e0125384 pubmed publisher |
Chu H, Rios C, Huang C, Wesolowska Andersen A, Burchard E, O Connor B, et al. CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18. Gene Ther. 2015;22:822-9 pubmed publisher |
Jiang X, Nevins J, Shats I, Chi J. E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. PLoS ONE. 2015;10:e0127951 pubmed publisher |
Fontes J, Ramsey J, Polk J, Koop A, Denisova J, Belousov A. Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin. PLoS ONE. 2015;10:e0125395 pubmed publisher |
Ha S, Ryu H, Chung K, Baek S, Kim E, Yu S. Regulation of autophagic cell death by glycogen synthase kinase-3β in adult hippocampal neural stem cells following insulin withdrawal. Mol Brain. 2015;8:30 pubmed publisher |
Paran C, Verkerke A, Heden T, Park S, Zou K, Lawson H, et al. Reduced efficiency of sarcolipin-dependent respiration in myocytes from humans with severe obesity. Obesity (Silver Spring). 2015;23:1440-9 pubmed publisher |
Lhoumeau A, Martinez S, Boher J, Monges G, Castellano R, Goubard A, et al. Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer. PLoS ONE. 2015;10:e0123768 pubmed publisher |
Sheridan J, Ritchie M, Best S, Jiang K, Beck T, Vaillant F, et al. A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1. BMC Cancer. 2015;15:221 pubmed publisher |
Ng A, Walia M, Smeets M, Mutsaers A, Sims N, Purton L, et al. The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation. PLoS Genet. 2015;11:e1005160 pubmed publisher |
Liang G, Liu G, Kitamura K, Wang Z, Chowdhury S, Monjurul A, et al. TGF-β suppression of HBV RNA through AID-dependent recruitment of an RNA exosome complex. PLoS Pathog. 2015;11:e1004780 pubmed publisher |
Draheim K, Li X, Zhang R, Fisher O, Villari G, Boggon T, et al. CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. J Cell Biol. 2015;208:987-1001 pubmed publisher |
Lin B, Li Y, Han L, Kaplan A, Ao Y, Kalra S, et al. Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Dis Model Mech. 2015;8:457-66 pubmed publisher |
Zhang X, Li K, Gao L, Li S, Chen K, Zhang J, et al. miR-191 promotes tumorigenesis of human colorectal cancer through targeting C/EBPβ. Oncotarget. 2015;6:4144-58 pubmed |
Power D, Santoso N, Dieringer M, Yu J, Huang H, Simpson S, et al. IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency. Virology. 2015;481:142-50 pubmed publisher |
Bouezzedine F, Fardel O, Gripon P. Interleukin 6 inhibits HBV entry through NTCP down regulation. Virology. 2015;481:34-42 pubmed publisher |
Le A, Huang Y, Pingle S, Kesari S, Wang H, Yong R, et al. Plexin-B2 promotes invasive growth of malignant glioma. Oncotarget. 2015;6:7293-304 pubmed |
Martínez Torres A, Quiney C, Attout T, Boullet H, Herbi L, Vela L, et al. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PLoS Med. 2015;12:e1001796 pubmed publisher |
Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol. 2015;208:563-79 pubmed publisher |
Xiong J, Todorova D, Su N, Kim J, Lee P, Shen Z, et al. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. J Cell Biol. 2015;208:513-20 pubmed publisher |
Purdy J, Shenk T, Rabinowitz J. Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication. Cell Rep. 2015;10:1375-85 pubmed publisher |
Chavez A, Scheiman J, Vora S, Pruitt B, Tuttle M, P R Iyer E, et al. Highly efficient Cas9-mediated transcriptional programming. Nat Methods. 2015;12:326-8 pubmed publisher |
Diner B, Li T, Greco T, Crow M, Fuesler J, Wang J, et al. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015;11:787 pubmed publisher |
Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, et al. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle. 2015;14:375-87 pubmed publisher |
Hundt J, Li Z, Liu Q. The inhibitory effects of anacardic acid on hepatitis C virus life cycle. PLoS ONE. 2015;10:e0117514 pubmed publisher |
Wen J, Wen X, Li R, Jin Y, Wang X, Zhou L, et al. UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/β-catenin pathway. PLoS ONE. 2015;10:e0115622 pubmed publisher |
Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro I, et al. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. J Biol Chem. 2015;290:7195-207 pubmed publisher |
Sharma K, Goehe R, Di X, Hicks M, Torti S, Torti F, et al. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy. 2014;10:2346-61 pubmed publisher |
Bruserud Ã, Reikvam H, Fredly H, Skavland J, Hagen K, van Hoang T, et al. Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. Oncotarget. 2015;6:2794-811 pubmed |
Qiao J, Cui S, Xu L, Chen S, Yao J, Jiang Y, et al. Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Oncotarget. 2015;6:1171-89 pubmed |
Diekman B, Thakore P, O Connor S, Willard V, Brunger J, Christoforou N, et al. Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells. Tissue Eng Part A. 2015;21:1261-74 pubmed publisher |
Smith M, Box A, Haug J, Lane W, Davido D. A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes. Cells. 2014;3:1131-58 pubmed publisher |
Guo B, Bellingham S, Hill A. The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. J Biol Chem. 2015;290:3455-67 pubmed publisher |
Socodato R, Portugal C, Canedo T, Domith I, Oliveira N, Paes de Carvalho R, et al. c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity. Free Radic Biol Med. 2015;79:45-55 pubmed publisher |
Mitter S, Song C, Qi X, Mao H, Rao H, Akin D, et al. Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy. 2014;10:1989-2005 pubmed publisher |
Duan L, Perez R, Hansen M, Gitelis S, Maki C. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer Biol Ther. 2014;15:1600-12 pubmed publisher |
Ye W, Zhou J, Markova D, Tian Y, Li J, Anderson D, et al. Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3. Am J Pathol. 2015;185:485-95 pubmed publisher |
Deegan S, Saveljeva S, Logue S, Pakos Zebrucka K, Gupta S, Vandenabeele P, et al. Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Autophagy. 2014;10:1921-36 pubmed publisher |
Wang Z, Mir M. Andes virus nucleocapsid protein interrupts protein kinase R dimerization to counteract host interference in viral protein synthesis. J Virol. 2015;89:1628-39 pubmed publisher |
Gutschner T. Silencing long noncoding RNAs with genome-editing tools. Methods Mol Biol. 2015;1239:241-50 pubmed publisher |
Ahmad K, Katryniok C, Scholz B, Merkens J, Löscher D, Marschalek R, et al. Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL. Oncogenesis. 2014;3:e127 pubmed publisher |
Patel U, Patel A, Joshi C. Stable suppression of myostatin gene expression in goat fetal fibroblast cells by lentiviral vector-mediated RNAi. Biotechnol Prog. 2015;31:452-9 pubmed publisher |
Wennmann D, Vollenbröker B, Eckart A, Bonse J, Erdmann F, Wolters D, et al. The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes. Cell Death Dis. 2014;5:e1519 pubmed publisher |
Chang K, Wei B, Madigan J, Hall M, Simpson R, Zhuang Z, et al. The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity. Mol Cancer Ther. 2015;14:90-100 pubmed publisher |
Geiger T, Ha N, Faraji F, Michael H, Rodriguez L, Walker R, et al. Functional analysis of prognostic gene expression network genes in metastatic breast cancer models. PLoS ONE. 2014;9:e111813 pubmed publisher |
Zhuang X, Ahmed F, Zhang Y, Ferguson H, Steele J, Steven N, et al. Robo4 vaccines induce antibodies that retard tumor growth. Angiogenesis. 2015;18:83-95 pubmed publisher |
Dunleavey J, Xiao L, Thompson J, Kim M, Shields J, Shelton S, et al. Vascular channels formed by subpopulations of PECAM1+ melanoma cells. Nat Commun. 2014;5:5200 pubmed publisher |
Li J, Yu H, Xi M, Ma D, Lu X. The SNAI1 3'UTR functions as a sponge for multiple migration-/invasion-related microRNAs. Tumour Biol. 2015;36:1067-72 pubmed publisher |
Chung J, Larsen A, Chen E, Bunz F. A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. J Biol Chem. 2014;289:33020-31 pubmed publisher |
Ko C, Lee S, Windisch M, Ryu W. DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional level. J Virol. 2014;88:13689-98 pubmed publisher |
Fan S, Wang Y, Lu J, Zheng Y, Wu D, Zhang Z, et al. CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. J Cell Biochem. 2015;116:502-13 pubmed publisher |
Csiszar A, Kutay B, Wirth S, Schmidt U, Macho Maschler S, Schreiber M, et al. Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Breast Cancer Res. 2014;16:433 pubmed publisher |
Baschieri F, Confalonieri S, Bertalot G, Di Fiore P, Dietmaier W, Leist M, et al. Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nat Commun. 2014;5:4839 pubmed publisher |
Mihaylov I, Cotmore S, Tattersall P. Complementation for an essential ancillary non-structural protein function across parvovirus genera. Virology. 2014;468-470:226-37 pubmed publisher |
Zhu C, Wang J, Shi B, Hu P, Ning B, Zhang Q, et al. The transcription factor FOXA2 suppresses gastric tumorigenesis in vitro and in vivo. Dig Dis Sci. 2015;60:109-17 pubmed publisher |
Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, et al. Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. J Immunol. 2014;193:2801-11 pubmed publisher |
Xu M, Nagati J, Xie J, Li J, Walters H, Moon Y, et al. An acetate switch regulates stress erythropoiesis. Nat Med. 2014;20:1018-26 pubmed publisher |
Wang X, Li C, Zhou L, Zhang N, Wang X, Ge X, et al. Porcine reproductive and respiratory syndrome virus counteracts the porcine intrinsic virus restriction factors-IFITM1 and Tetherin in MARC-145 cells. Virus Res. 2014;191:92-100 pubmed publisher |
Siegle J, Basin A, Sastre Perona A, Yonekubo Y, Brown J, Sennett R, et al. SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma. Nat Commun. 2014;5:4511 pubmed publisher |
Choi K, Ghaddar B, Moya C, Shi H, Sridharan G, Lee K, et al. Analysis of transcription factor network underlying 3T3-L1 adipocyte differentiation. PLoS ONE. 2014;9:e100177 pubmed publisher |
Wang X, Wang H, Yang H, Li J, Cai Q, Shapiro I, et al. Tumor necrosis factor-?- and interleukin-1?-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-?B axis: implications in inflammatory disc dis. Am J Pathol. 2014;184:2560-72 pubmed publisher |
Guerrero P, Yin W, Camacho L, Marchetti D. Oncogenic role of Merlin/NF2 in glioblastoma. Oncogene. 2015;34:2621-30 pubmed publisher |
Qian J, Wu C, Chen X, Li X, Ying G, Jin L, et al. Differential requirements of arrestin-3 and clathrin for ligand-dependent and -independent internalization of human G protein-coupled receptor 40. Cell Signal. 2014;26:2412-23 pubmed publisher |
Chen Y, Hsu W, Ma Y, Tai D, Lee E. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. J Neurosci. 2014;34:9574-89 pubmed publisher |
Neshati Z, Liu J, Zhou G, Schalij M, de Vries A. Development of a lentivirus vector-based assay for non-destructive monitoring of cell fusion activity. PLoS ONE. 2014;9:e102433 pubmed publisher |
Williams S, Ratliff L, Postiglione M, Knoblich J, Fuchs E. Par3-mInsc and G?i3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 2014;16:758-69 pubmed publisher |
Iyer S, Han L, Bartell S, Kim H, Gubrij I, De Cabo R, et al. Sirtuin1 (Sirt1) promotes cortical bone formation by preventing ?-catenin sequestration by FoxO transcription factors in osteoblast progenitors. J Biol Chem. 2014;289:24069-78 pubmed publisher |
Hartsink Segers S, Beaudoin J, Luijendijk M, Exalto C, Pieters R, den Boer M. PKC? and PKM? are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. Leukemia. 2015;29:304-11 pubmed publisher |
Zhang X, Ma D, Caruso M, Lewis M, Qi Y, Yi Z. Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. J Proteomics. 2014;109:63-75 pubmed publisher |
Taylor A, Herrmann A, Moss D, See V, Davies K, Williams S, et al. Assessing the efficacy of nano- and micro-sized magnetic particles as contrast agents for MRI cell tracking. PLoS ONE. 2014;9:e100259 pubmed publisher |
Heckl D, Kowalczyk M, Yudovich D, Belizaire R, Puram R, McConkey M, et al. Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing. Nat Biotechnol. 2014;32:941-6 pubmed publisher |
Duan L, Ying G, Danzer B, Perez R, Shariat Madar Z, Levenson V, et al. The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. J Biol Chem. 2014;289:21694-705 pubmed publisher |
Hall M, Marshall T, Kwit A, Miller Jenkins L, Dulcey A, Madigan J, et al. Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin. J Biol Chem. 2014;289:21473-89 pubmed publisher |
Jouroukhin Y, Nonyane B, Gilad A, Pelled G. Molecular neuroimaging of post-injury plasticity. J Mol Neurosci. 2014;54:630-8 pubmed publisher |
Wei M, Chen M, Chen K, Lou P, Lin S, Hung S, et al. Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Autophagy. 2014;10:1179-92 pubmed publisher |
Jang J, Wang Y, Kim H, Lalli M, Kosik K. Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Stem Cells. 2014;32:2616-25 pubmed publisher |
Charles J, Fuchs J, Hefter M, Vischedyk J, Kleint M, Vogiatzi F, et al. Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases. Nat Commun. 2014;5:3981 pubmed publisher |
Hirose Y, Johnson Z, Schoepflin Z, Markova D, Chiba K, Toyama Y, et al. FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells. J Biol Chem. 2014;289:20594-605 pubmed |
Lin Z, Wang L, Zhang J, Liu Y, Li X, Guo L, et al. MST4 promotes hepatocellular carcinoma epithelial-mesenchymal transition and metastasis via activation of the p-ERK pathway. Int J Oncol. 2014;45:629-40 pubmed publisher |
Carpp L, Rogers R, Moritz R, Aitchison J. Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection. Mol Cell Proteomics. 2014;13:2836-54 pubmed publisher |
North B, Rosenberg M, Jeganathan K, Hafner A, Michan S, Dai J, et al. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014;33:1438-53 pubmed publisher |
Zhang X, Weissman S, Newburger P. Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. RNA Biol. 2014;11:777-87 pubmed |
Deroyer C, Rénert A, Merville M, Fillet M. New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. Autophagy. 2014;10:1229-40 pubmed publisher |
Lv T, Liu Y, Zhang J, Xu L, Zhu Y, Yin H, et al. Impact of an altered PROX1 expression on clinicopathology, prognosis and progression in renal cell carcinoma. PLoS ONE. 2014;9:e95996 pubmed publisher |
Glass K, Link J, Brunger J, Moutos F, Gersbach C, Guilak F. Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Biomaterials. 2014;35:5921-31 pubmed publisher |
Mathison M, Singh V, Gersch R, Ramirez M, Cooney A, Kaminsky S, et al. "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. J Thorac Cardiovasc Surg. 2014;148:1656-1664.e2 pubmed publisher |
Bartolomé A, Kimura Koyanagi M, Asahara S, Guillen C, Inoue H, Teruyama K, et al. Pancreatic ?-cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes. 2014;63:2996-3008 pubmed publisher |
Zhang W, Ruvolo V, Gao C, Zhou L, Bornmann W, Tsao T, et al. Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Mol Cancer Ther. 2014;13:1848-59 pubmed publisher |
Park S, Yu S, Chai Y, Jang Y. CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression. Nucleic Acids Res. 2014;42:6196-207 pubmed publisher |
Shimamoto R, Amano N, Ichisaka T, Watanabe A, Yamanaka S, Okita K. Generation and characterization of induced pluripotent stem cells from Aid-deficient mice. PLoS ONE. 2014;9:e94735 pubmed publisher |
Mitchell R, Szabo E, Benoit Y, Case D, Mechael R, Alamilla J, et al. Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Stem Cells Dev. 2014;23:1937-46 pubmed publisher |
Patel A, Tripathi A, Patel U, Shah R, Joshi C. Myostatin knockdown and its effect on myogenic gene expression program in stably transfected goat myoblasts. In Vitro Cell Dev Biol Anim. 2014;50:587-96 pubmed publisher |
Wennmann D, Schmitz J, Wehr M, Krahn M, Koschmal N, Gromnitza S, et al. Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Mol Biol Evol. 2014;31:1710-23 pubmed publisher |
Miyagawa Yamaguchi A, Kotani N, Honke K. Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains. PLoS ONE. 2014;9:e93054 pubmed publisher |
Zhang L, Zhou M, Qin G, Weintraub N, Tang Y. MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress. Biochem Biophys Res Commun. 2014;446:952-8 pubmed publisher |
Dennis M, Mogridge J. A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Biochemistry. 2014;53:2166-71 pubmed publisher |
Ariës I, Jerchel I, van den Dungen R, van den Berk L, Boer J, Horstmann M, et al. EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion. Leukemia. 2014;28:1828-37 pubmed publisher |
Smith G, Kumar A, Saba J. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules. 2013;3:351-368 pubmed |
Hu L, Yao W, Wang F, Rong X, Peng T. GP73 is upregulated by hepatitis C virus (HCV) infection and enhances HCV secretion. PLoS ONE. 2014;9:e90553 pubmed publisher |
Lung H, Man O, Yeung M, Ko J, Cheung A, Law E, et al. SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma. Oncogene. 2015;34:878-89 pubmed publisher |
Pérez González A, Pazo A, Navajas R, Ciordia S, Rodriguez Frandsen A, Nieto A. hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. PLoS ONE. 2014;9:e90957 pubmed publisher |
Nasri M, Karimi A, Allahbakhshian Farsani M. Production, purification and titration of a lentivirus-based vector for gene delivery purposes. Cytotechnology. 2014;66:1031-8 pubmed publisher |
Moreno E, Moreno Delgado D, Navarro G, Hoffmann H, Fuentes S, Rosell Vilar S, et al. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: ?1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci. 2014;34:3545-58 pubmed publisher |
Ifkovits J, Addis R, Epstein J, Gearhart J. Inhibition of TGF? signaling increases direct conversion of fibroblasts to induced cardiomyocytes. PLoS ONE. 2014;9:e89678 pubmed publisher |
Mallya S, Fitch B, Lee J, So L, Janes M, Fruman D. Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1. PLoS ONE. 2014;9:e88865 pubmed publisher |
Schulze U, Vollenbröker B, Braun D, Van Le T, Granado D, Kremerskothen J, et al. The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Mol Cell Proteomics. 2014;13:1397-411 pubmed publisher |
Kim E, Kim A, Kim S, Kim H, Chang J, Ahn C, et al. Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3? signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells. Respir Res. 2014;15:26 pubmed publisher |
Pelascini L, Gonçalves M. Lentiviral vectors encoding zinc-finger nucleases specific for the model target locus HPRT1. Methods Mol Biol. 2014;1114:181-99 pubmed publisher |
Brunger J, Huynh N, Guenther C, Perez Pinera P, Moutos F, Sanchez Adams J, et al. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. Proc Natl Acad Sci U S A. 2014;111:E798-806 pubmed publisher |
Schwankhaus N, Gathmann C, Wicklein D, Riecken K, Schumacher U, Valentiner U. Cell adhesion molecules in metastatic neuroblastoma models. Clin Exp Metastasis. 2014;31:483-96 pubmed publisher |
Arason A, Jónsdóttir H, Halldorsson S, Benediktsdóttir B, Bergthorsson J, Ingthorsson S, et al. deltaNp63 has a role in maintaining epithelial integrity in airway epithelium. PLoS ONE. 2014;9:e88683 pubmed publisher |
Khare S, Ratsimandresy R, de Almeida L, Cuda C, Rellick S, Misharin A, et al. The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol. 2014;15:343-53 pubmed publisher |
Leyton Mange J, Mills R, Macri V, Jang M, Butte F, Ellinor P, et al. Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Stem Cell Reports. 2014;2:163-70 pubmed publisher |
Iempridee T, Reusch J, Riching A, JOHANNSEN E, Dovat S, Kenney S, et al. Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells. J Virol. 2014;88:4811-27 pubmed publisher |
Leoh L, Morizono K, Kershaw K, Chen I, Penichet M, Daniels Wells T. Gene delivery in malignant B cells using the combination of lentiviruses conjugated to anti-transferrin receptor antibodies and an immunoglobulin promoter. J Gene Med. 2014;16:11-27 pubmed publisher |
Guan X, Mack D, Moreno C, Strande J, Mathieu J, Shi Y, et al. Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Stem Cell Res. 2014;12:467-80 pubmed publisher |
Offer S, Butterfield G, Jerde C, Fossum C, Wegner N, Diasio R. microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Mol Cancer Ther. 2014;13:742-51 pubmed publisher |
Zhang L, Pan Y, Qin G, Chen L, Chatterjee T, Weintraub N, et al. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle. 2014;13:762-71 pubmed publisher |
Bagnall J, Leedale J, Taylor S, Spiller D, White M, Sharkey K, et al. Tight control of hypoxia-inducible factor-? transient dynamics is essential for cell survival in hypoxia. J Biol Chem. 2014;289:5549-64 pubmed publisher |
Dey D, Eckle V, Vitko I, Sullivan K, Lasiecka Z, Winckler B, et al. A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus. Epilepsia. 2014;55:203-13 pubmed publisher |
Yan H, Wang X, Zhang Q, Tang Z, Jiang Y, Fan H, et al. Reduced expression of the chromatin remodeling gene ARID1A enhances gastric cancer cell migration and invasion via downregulation of E-cadherin transcription. Carcinogenesis. 2014;35:867-76 pubmed publisher |
Li Z, Tang M, Ling B, Liu S, Zheng Y, Nie C, et al. Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma. J Mol Med (Berl). 2014;92:291-303 pubmed publisher |
Padmashali R, You H, Karnik N, Lei P, Andreadis S. Adherens junction formation inhibits lentivirus entry and gene transfer. PLoS ONE. 2013;8:e79265 pubmed publisher |
Guan B, Magomi T, Wang T, Shih I. Establishing isogenic inducible cell lines using founder reporter lines and recombinase-mediated cassette exchange. Biotechniques. 2013;55:233-42 pubmed publisher |
Berrè S, Gaudin R, Cunha de Alencar B, Desdouits M, Chabaud M, Naffakh N, et al. CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells. J Exp Med. 2013;210:2523-38 pubmed publisher |
Shakhbazau A, Mohanty C, Shcharbin D, Bryszewska M, Caminade A, Majoral J, et al. Doxycycline-regulated GDNF expression promotes axonal regeneration and functional recovery in transected peripheral nerve. J Control Release. 2013;172:841-51 pubmed publisher |
Ryzhov S, Biktasova A, Goldstein A, Zhang Q, Biaggioni I, Dikov M, et al. Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Mol Pharmacol. 2014;85:62-73 pubmed publisher |
Habersetzer J, Larrieu I, Priault M, Salin B, Rossignol R, Brèthes D, et al. Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter?. PLoS ONE. 2013;8:e75429 pubmed publisher |
Cservenák M, Szabó Ã, Bodnár I, Lékó A, Palkovits M, Nagy G, et al. Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation. Psychoneuroendocrinology. 2013;38:3070-84 pubmed publisher |
O Leary V, Ovsepian S, Bodeker M, Dolly J. Improved lentiviral transduction of ALS motoneurons in vivo via dual targeting. Mol Pharm. 2013;10:4195-206 pubmed publisher |
Carrion B, Kong Y, Kaigler D, Putnam A. Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their ?6?1 integrin receptor. Exp Cell Res. 2013;319:2964-76 pubmed publisher |
Kivi R, Loog M, Jemth P, Järv J. Kinetics of acrylodan-labelled cAMP-dependent protein kinase catalytic subunit denaturation. Protein J. 2013;32:519-25 pubmed publisher |
L homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, et al. Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. J Lipid Res. 2013;54:2998-3008 pubmed publisher |
Neviani P, Harb J, Oaks J, Santhanam R, Walker C, Ellis J, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. J Clin Invest. 2013;123:4144-57 pubmed publisher |
McGinley L, McMahon J, Stocca A, Duffy A, Flynn A, O Toole D, et al. Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression. Hum Gene Ther. 2013;24:840-51 pubmed publisher |
Nguyen G, Molero A, Gokhan S, Mehler M. Functions of huntingtin in germ layer specification and organogenesis. PLoS ONE. 2013;8:e72698 pubmed publisher |
Ramsey J, Fontes J. The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression. Mol Immunol. 2013;56:768-80 pubmed publisher |
Tran A, Rahim M, Ranadheera C, Kroeker A, Cortens J, Opanubi K, et al. Knockdown of specific host factors protects against influenza virus-induced cell death. Cell Death Dis. 2013;4:e769 pubmed publisher |
Salloum S, Wang H, Ferguson C, Parton R, Tai A. Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. PLoS Pathog. 2013;9:e1003513 pubmed publisher |
Du J, Campau E, Soragni E, Jespersen C, Gottesfeld J. Length-dependent CTG·CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells. Hum Mol Genet. 2013;22:5276-87 pubmed publisher |
Caligiuri I, Toffoli G, Giordano A, Rizzolio F. pRb controls estrogen receptor alpha protein stability and activity. Oncotarget. 2013;4:875-83 pubmed |
Leucker T, Ge Z, Procknow J, Liu Y, Shi Y, Bienengraeber M, et al. Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. PLoS ONE. 2013;8:e70088 pubmed publisher |
Firczuk M, Gabrysiak M, Barankiewicz J, Domagala A, Nowis D, Kujawa M, et al. GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy. Cell Death Dis. 2013;4:e741 pubmed publisher |
Dimitrov E, Kuo J, Kohno K, Usdin T. Neuropathic and inflammatory pain are modulated by tuberoinfundibular peptide of 39 residues. Proc Natl Acad Sci U S A. 2013;110:13156-61 pubmed publisher |
Potluri V, Noothi S, Vallabhapurapu S, Yoon S, Driscoll J, Lawrie C, et al. Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma. PLoS ONE. 2013;8:e66121 pubmed publisher |
Cao H, Jheon A, Li X, Sun Z, Wang J, Florez S, et al. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development. 2013;140:3348-59 pubmed publisher |
Evangelou K, Bartkova J, Kotsinas A, Pateras I, Liontos M, Velimezi G, et al. The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis. Cell Death Differ. 2013;20:1485-97 pubmed publisher |
Sartoretto J, Kalwa H, Romero N, Michel T. In vivo imaging of nitric oxide and hydrogen peroxide in cardiac myocytes. Methods Enzymol. 2013;528:61-78 pubmed publisher |
Gov L, Karimzadeh A, Ueno N, Lodoen M. Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15. MBio. 2013;4: pubmed publisher |
Mastrocola A, Kim S, Trinh A, Rodenkirch L, Tibbetts R. The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage. J Biol Chem. 2013;288:24731-41 pubmed publisher |
Cooper M, Cox N, Zimmerman E, Dewar B, Duncan J, Whittle M, et al. Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS ONE. 2013;8:e66755 pubmed publisher |
Stefos G, Soppa U, Dierssen M, Becker W. NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect. PLoS ONE. 2013;8:e67470 pubmed publisher |
Baird B, Schliekelman M, Ahn Y, Chen Y, Roybal J, Gill B, et al. Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. PLoS ONE. 2013;8:e67054 pubmed publisher |
Ambjørn M, Dubreuil V, Miozzo F, Nigon F, Møller B, Issazadeh Navikas S, et al. A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. PLoS ONE. 2013;8:e65371 pubmed publisher |
de Seny D, Cobraiville G, Charlier E, Neuville S, Esser N, Malaise D, et al. Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties. PLoS ONE. 2013;8:e66769 pubmed publisher |
Lu X, Mazur S, Lin T, Appella E, Xu Y. The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis. Oncogene. 2014;33:2655-64 pubmed publisher |
Wu Y, Zhang X, Kang X, Li N, Wang R, Hu T, et al. Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells. Clin Exp Pharmacol Physiol. 2013;40:626-34 pubmed publisher |
Chakraborty S, Christoforou N, Fattahi A, Herzog R, Leong K. A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells. PLoS ONE. 2013;8:e64342 pubmed publisher |
Crossland H, Kazi A, Lang C, Timmons J, Pierre P, Wilkinson D, et al. Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Am J Physiol Endocrinol Metab. 2013;305:E183-93 pubmed publisher |
Li Z, Hudson F, Wang H, Wang Y, Bian Z, Murnane J, et al. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res. 2013;180:17-24 pubmed publisher |
Harkey M, Asano A, Zoulas M, Torok Storb B, Nagashima J, Travis A. Isolation, genetic manipulation, and transplantation of canine spermatogonial stem cells: progress toward transgenesis through the male germ-line. Reproduction. 2013;146:75-90 pubmed publisher |
Kröger C, Loschke F, Schwarz N, Windoffer R, Leube R, Magin T. Keratins control intercellular adhesion involving PKC-?-mediated desmoplakin phosphorylation. J Cell Biol. 2013;201:681-92 pubmed publisher |
Wendt T, Holm P, Starker C, Christian M, Voytas D, Brinch Pedersen H, et al. TAL effector nucleases induce mutations at a pre-selected location in the genome of primary barley transformants. Plant Mol Biol. 2013;83:279-85 pubmed publisher |
Ding B, Kilpatrick D. Lentiviral vector production, titration, and transduction of primary neurons. Methods Mol Biol. 2013;1018:119-31 pubmed publisher |
Raver R, Panfil A, Hagemeier S, Kenney S. The B-cell-specific transcription factor and master regulator Pax5 promotes Epstein-Barr virus latency by negatively regulating the viral immediate early protein BZLF1. J Virol. 2013;87:8053-63 pubmed publisher |
Bhatt S, Ashlock B, Toomey N, Diaz L, Mesri E, Lossos I, et al. Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma. J Clin Invest. 2013;123:2616-28 pubmed publisher |
Ouyang H, Qin Y, Liu Y, Xie Y, Liu J. Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. PLoS ONE. 2013;8:e62192 pubmed publisher |
Tan B, Kang O, Mai C, Tiong K, Khoo A, Pichika M, et al. 6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor ? (PPAR?). Cancer Lett. 2013;336:127-39 pubmed publisher |
Wang H, Tian Y, Wang J, Phillips K, Binch A, Dunn S, et al. Inflammatory cytokines induce NOTCH signaling in nucleus pulposus cells: implications in intervertebral disc degeneration. J Biol Chem. 2013;288:16761-74 pubmed publisher |
Jensen Urstad A, Song H, Lodhi I, Funai K, Yin L, Coleman T, et al. Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPAR?. J Lipid Res. 2013;54:1848-59 pubmed publisher |
Wang D, Li G, Schauflinger M, Nguyen C, Hall E, Yurochko A, et al. The ULb' region of the human cytomegalovirus genome confers an increased requirement for the viral protein kinase UL97. J Virol. 2013;87:6359-76 pubmed publisher |
Tran C, Fujita N, Huang B, Ong J, Lyons K, Shapiro I, et al. Hypoxia-inducible factor (HIF)-1? and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1? level and transcriptional activity. J Biol Chem. 2013;288:12654-66 pubmed publisher |
Pol S, Lang J, O Bara M, Cimato T, McCallion A, Sim F. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate. Exp Neurol. 2013;247:694-702 pubmed publisher |
Kuroda K, Kuang S, Taketo M, Rudnicki M. Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts. Skelet Muscle. 2013;3:5 pubmed publisher |
Smith M, Goddard E, Perusina Lanfranca M, Davido D. hTERT extends the life of human fibroblasts without compromising type I interferon signaling. PLoS ONE. 2013;8:e58233 pubmed publisher |
Dugast E, Kiss Toth E, Docherty L, Danger R, Chesneau M, Pichard V, et al. Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells. J Biol Chem. 2013;288:10051-60 pubmed publisher |
Chen K, Huang Y, Lung J, Yeh Y, Yuan K. CD44 is involved in mineralization of dental pulp cells. J Endod. 2013;39:351-6 pubmed publisher |
Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor ? in breast cancer. PLoS ONE. 2013;8:e55355 pubmed publisher |
Nunes P, Ernandez T, Roth I, Qiao X, Strebel D, Bouley R, et al. Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Autophagy. 2013;9:550-67 pubmed publisher |
Emerling B, Benes C, Poulogiannis G, Bell E, Courtney K, Liu H, et al. Identification of CDCP1 as a hypoxia-inducible factor 2? (HIF-2?) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A. 2013;110:3483-8 pubmed publisher |
Garncarz W, Tariq A, Handl C, Pusch O, Jantsch M. A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing. RNA Biol. 2013;10:192-204 pubmed publisher |
Chen R, Wislet Gendebien S, Samuel F, Visanji N, Zhang G, Marsilio D, et al. ?-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity. J Biol Chem. 2013;288:7438-49 pubmed publisher |
Adler A, Grigsby C, Kulangara K, Wang H, Yasuda R, Leong K. Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells. Mol Ther Nucleic Acids. 2012;1:e32 pubmed publisher |
Plank M, Hu G, Silva A, Wood S, Hesketh E, Janssens G, et al. An analysis and validation pipeline for large-scale RNAi-based screens. Sci Rep. 2013;3:1076 pubmed publisher |
Beronja S, Fuchs E. RNAi-mediated gene function analysis in skin. Methods Mol Biol. 2013;961:351-61 pubmed publisher |
Lechner S, Mitterberger M, Mattesich M, Zwerschke W. Role of C/EBP?-LAP and C/EBP?-LIP in early adipogenic differentiation of human white adipose-derived progenitors and at later stages in immature adipocytes. Differentiation. 2013;85:20-31 pubmed publisher |
Arampatzi P, Gialitakis M, Makatounakis T, Papamatheakis J. Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements. Nucleic Acids Res. 2013;41:2202-15 pubmed publisher |
Tariq A, Garncarz W, Handl C, Balik A, Pusch O, Jantsch M. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Nucleic Acids Res. 2013;41:2581-93 pubmed publisher |
Holkers M, Maggio I, Liu J, Janssen J, Miselli F, Mussolino C, et al. Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res. 2013;41:e63 pubmed publisher |
Hertz M, Landry D, Willis A, Luo G, Thompson S. Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting. Mol Cell Biol. 2013;33:1016-26 pubmed publisher |
Wang J, Tian Y, Phillips K, Chiverton N, Haddock G, Bunning R, et al. Tumor necrosis factor ?- and interleukin-1?-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1. Arthritis Rheum. 2013;65:832-42 pubmed publisher |
Lian X, Zhang J, Zhu K, Kamp T, Palecek S. Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Stem Cells. 2013;31:447-57 pubmed publisher |
Bohle V, Doring C, Hansmann M, Kuppers R. Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma. Leukemia. 2013;27:671-9 pubmed publisher |
Green V, Arbuthnot P, Weinberg M. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells. Virol J. 2012;9:272 pubmed publisher |
Tran A, Cortens J, Du Q, Wilkins J, Coombs K. Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation. J Virol. 2013;87:1049-60 pubmed publisher |
Jin F, Ji H, Jia C, Brockmeier U, Hermann D, Metzen E, et al. Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116. PLoS ONE. 2012;7:e47161 pubmed publisher |
Cocka L, Bates P. Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities. PLoS Pathog. 2012;8:e1002931 pubmed publisher |
Marchesi I, Fiorentino F, Rizzolio F, Giordano A, Bagella L. The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. Cell Cycle. 2012;11:3828-36 pubmed publisher |
Baritaud M, Cabon L, Delavallée L, Galán Malo P, Gilles M, Brunelle Navas M, et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis. 2012;3:e390 pubmed publisher |
Cox J, Wilder P, Desler M, Rizzino A. Elevating SOX2 levels deleteriously affects the growth of medulloblastoma and glioblastoma cells. PLoS ONE. 2012;7:e44087 pubmed publisher |
La Montagna R, Caligiuri I, Maranta P, Lucchetti C, Esposito L, Paggi M, et al. Androgen receptor serine 81 mediates Pin1 interaction and activity. Cell Cycle. 2012;11:3415-20 pubmed publisher |
Schnabel L, Abratte C, Schimenti J, Southard T, Fortier L. Genetic background affects induced pluripotent stem cell generation. Stem Cell Res Ther. 2012;3:30 pubmed publisher |
Yao H, Ashihara E, Strovel J, Nakagawa Y, Kuroda J, Nagao R, et al. AV-65, a novel Wnt/?-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model. Blood Cancer J. 2011;1:e43 pubmed publisher |
Briggs A, Rios X, Chari R, Yang L, Zhang F, Mali P, et al. Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res. 2012;40:e117 pubmed publisher |
Sabatel H, Di Valentin E, Gloire G, Dequiedt F, Piette J, Habraken Y. Phosphorylation of p65(RelA) on Ser(547) by ATM represses NF-?B-dependent transcription of specific genes after genotoxic stress. PLoS ONE. 2012;7:e38246 pubmed publisher |
Mak A, Moffat J. A versatile lentiviral expression system to identify mammalian protein-protein interactions. Methods. 2012;57:409-16 pubmed publisher |
Svensson J, Fry R, Wang E, Somoza L, Samson L. Identification of novel human damage response proteins targeted through yeast orthology. PLoS ONE. 2012;7:e37368 pubmed publisher |
Fan S, Niu Y, Tan N, Wu Z, Wang Y, You H, et al. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Oncogene. 2013;32:1682-90 pubmed publisher |
Fischedick G, Klein D, Wu G, Esch D, Höing S, Han D, et al. Zfp296 is a novel, pluripotent-specific reprogramming factor. PLoS ONE. 2012;7:e34645 pubmed publisher |
Manic G, Maurin Marlin A, Galluzzi L, Subra F, Mouscadet J, Bury Moné S. 3' self-inactivating long terminal repeat inserts for the modulation of transgene expression from lentiviral vectors. Hum Gene Ther Methods. 2012;23:84-97 pubmed publisher |
Fujita N, Markova D, Anderson D, Chiba K, Toyama Y, Shapiro I, et al. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1? activity in hypoxia. J Biol Chem. 2012;287:16975-86 pubmed publisher |
Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein Szanto A, et al. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012;19:1152-61 pubmed publisher |
Addis R, Hsu F, Wright R, Dichter M, Coulter D, Gearhart J. Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. PLoS ONE. 2011;6:e28719 pubmed publisher |
Cronan M, Nakamura K, Johnson N, Granger D, Cuevas B, Wang J, et al. Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis. Oncogene. 2012;31:3889-900 pubmed publisher |
Munoz N, Beard B, Ryu B, Luche R, Trobridge G, Rawlings D, et al. Novel reporter systems for facile evaluation of I-SceI-mediated genome editing. Nucleic Acids Res. 2012;40:e14 pubmed publisher |
Orthwein A, Zahn A, Methot S, Godin D, Conticello S, Terada K, et al. Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1. EMBO J. 2012;31:679-91 pubmed publisher |
Bandaranayake A, Correnti C, Ryu B, Brault M, Strong R, Rawlings D. Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors. Nucleic Acids Res. 2011;39:e143 pubmed publisher |
Guan B, Wang T, Shih I. ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Cancer Res. 2011;71:6718-27 pubmed publisher |
Visanji N, Wislet Gendebien S, Oschipok L, Zhang G, Aubert I, Fraser P, et al. Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. J Biol Chem. 2011;286:35863-73 pubmed publisher |
Nethercott H, Brick D, Schwartz P. Derivation of induced pluripotent stem cells by lentiviral transduction. Methods Mol Biol. 2011;767:67-85 pubmed publisher |
Kazi A, Hong Brown L, Lang S, Lang C. Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Mol Med. 2011;17:925-36 pubmed publisher |
Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, et al. The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS ONE. 2011;6:e19151 pubmed publisher |
Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C. Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-?. PLoS Pathog. 2011;7:e1002016 pubmed publisher |
Ruan J, Shen J, Wang Z, Ji J, Song H, Wang K, et al. Efficient preparation and labeling of human induced pluripotent stem cells by nanotechnology. Int J Nanomedicine. 2011;6:425-35 pubmed publisher |
Taxman D, Holley Guthrie E, Huang M, Moore C, Bergstralh D, Allen I, et al. The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem. 2011;286:19605-16 pubmed publisher |
Zhu D, Shi J, Liu S, Liu Y, Zheng D. HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species. PLoS ONE. 2011;6:e18291 pubmed publisher |
Kawazu M, Saso K, Tong K, McQuire T, Goto K, Son D, et al. Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development. PLoS ONE. 2011;6:e17830 pubmed publisher |
McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O Toole D, et al. Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia. Stem Cell Res Ther. 2011;2:12 pubmed publisher |
Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba J. S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Cell Death Dis. 2011;2:e119 pubmed publisher |
Bell E, Emerling B, Ricoult S, Guarente L. SirT3 suppresses hypoxia inducible factor 1? and tumor growth by inhibiting mitochondrial ROS production. Oncogene. 2011;30:2986-96 pubmed publisher |
Liu G, Barkho B, Ruiz S, Diep D, Qu J, Yang S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011;472:221-5 pubmed publisher |
Matus Nicodemos R, Vavassori S, Castro Faix M, Valentin Acevedo A, Singh K, Marcelli V, et al. Polypyrimidine tract-binding protein is critical for the turnover and subcellular distribution of CD40 ligand mRNA in CD4+ T cells. J Immunol. 2011;186:2164-71 pubmed publisher |
Eyre N, Drummer H, Beard M. The SR-BI partner PDZK1 facilitates hepatitis C virus entry. PLoS Pathog. 2010;6:e1001130 pubmed publisher |
Ruvolo V, Karanjeet K, Schuster T, BROWN R, Deng Y, HINCHCLIFFE E, et al. Role for PKC ? in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells. J Signal Transduct. 2010;2010:584657 pubmed |
Chuang C, Wallace M, Abratte C, Southard T, Schimenti J. Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. PLoS Genet. 2010;6:e1001110 pubmed publisher |
Muck C, Herndler Brandstetter D, Micutkova L, Grubeck Loebenstein B, Jansen Durr P. Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. J Gerontol A Biol Sci Med Sci. 2010;65:1165-80 pubmed publisher |
Dettmer U, Kuhn P, Abou Ajram C, Lichtenthaler S, Kruger M, Kremmer E, et al. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. J Biol Chem. 2010;285:26174-81 pubmed publisher |
Bryan N, Dorfleutner A, Kramer S, Yun C, Rojanasakul Y, Stehlik C. Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes. J Inflamm (Lond). 2010;7:23 pubmed publisher |
Patel S, Simon M. Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos. J Biol Chem. 2010;285:15587-98 pubmed publisher |
Frank R, Edmiston M, Kendall S, Najbauer J, Cheung C, Kassa T, et al. Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. PLoS ONE. 2009;4:e8314 pubmed publisher |
Abbott S, Stornetta R, Socolovsky C, West G, Guyenet P. Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats. J Physiol. 2009;587:5613-31 pubmed publisher |
Lehotzky A, Lau P, Tokési N, Muja N, Hudson L, Ovádi J. Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Glia. 2010;58:157-68 pubmed publisher |
Borovski T, Verhoeff J, Ten Cate R, Cameron K, de Vries N, van Tellingen O, et al. Tumor microvasculature supports proliferation and expansion of glioma-propagating cells. Int J Cancer. 2009;125:1222-30 pubmed publisher |
Schmitz R, Hansmann M, Bohle V, Martin Subero J, Hartmann S, Mechtersheimer G, et al. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med. 2009;206:981-9 pubmed publisher |
Roca H, Varsos Z, Pienta K. CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation. J Biol Chem. 2008;283:25057-73 pubmed publisher |
Zetterstrom T, Sharp T, Collin A, Ungerstedt U. In vivo measurement of extracellular dopamine and DOPAC in rat striatum after various dopamine-releasing drugs; implications for the origin of extracellular DOPAC. Eur J Pharmacol. 1988;148:327-34 pubmed |
