Deutzmann A, Sullivan D, Dhanasekaran R, Li W, Chen X, Tong L, et al. Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma. Nat Commun. 2024;15:963 pubmed publisher

Janicot R, Maziarz M, Park J, Luebbers A, Green E, Zhao J, et al. Direct interrogation of context-dependent GPCR activity with a universal biosensor platform. bioRxiv. 2024;: pubmed publisher

Randolph K, Hyder U, Challa A, Perez E, D Orso I. Functional Analysis of KAP1/TRIM28 Requirements for HIV-1 Transcription Activation. Viruses. 2024;16: pubmed publisher

Liao X, Li W, Zhou H, Rajendran B, Li A, Ren J, et al. The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells. Nat Commun. 2024;15:603 pubmed publisher

Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye -, Ye Y, et al. c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer. Cell Death Dis. 2024;15:61 pubmed publisher

Zapanta Rinonos S, Li T, Pianka S, Prins T, Eldred B, Kevan B, et al. dCas9/CRISPR-based methylation of O-6-methylguanine-DNA methyltransferase enhances chemosensitivity to temozolomide in malignant glioma. J Neurooncol. 2024;: pubmed publisher

Vasudevan H, Payne E, Delley C, John Liu S, Mirchia K, Sale M, et al. Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance. Nat Commun. 2024;15:477 pubmed publisher

Sharma P, Maklashina E, Voehler M, Balintova S, Dvorakova S, Kraus M, et al. Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners. Nat Commun. 2024;15:473 pubmed publisher

Xu X, Zhu N, Zheng J, Peng Y, Zeng M, Deng K, et al. EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation. PLoS Pathog. 2024;20:e1011934 pubmed publisher

Cho M, Kumar R, Lin C, Boyer J, Shahir J, Fagan Solis K, et al. MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis. Nature. 2024;: pubmed publisher

Qin M, Geng E, Wang J, Yu M, Dong T, Li S, et al. LATS2 condensates organize signalosomes for Hippo pathway signal transduction. Nat Chem Biol. 2024;: pubmed publisher

Gao L, Behrens A, Rodschinka G, Forcelloni S, Wani S, Strasser K, et al. Selective gene expression maintains human tRNA anticodon pools during differentiation. Nat Cell Biol. 2024;: pubmed publisher

Wang X, Zhu Y, Liu T, Zhou L, Fu Y, Zhao J, et al. Duchenne muscular dystrophy treatment with lentiviral vector containing mini-dystrophin gene in vivo. MedComm (2020). 2024;5:e423 pubmed publisher

Tegtmeyer M, Arora J, Asgari S, Cimini B, Nadig A, Peirent E, et al. High-dimensional phenotyping to define the genetic basis of cellular morphology. Nat Commun. 2024;15:347 pubmed publisher

Ren Q, Huang D, Zhang X, Wang Y, Zhou Y, Zhang M, et al. Two somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma. Commun Biol. 2024;7:22 pubmed publisher

Clayton N, Hodge R, Infante E, Alibhai D, Zhou F, Ridley A. RhoU forms homo-oligomers to regulate cellular responses. J Cell Sci. 2024;: pubmed publisher

Huang Y, Peng Q, Tian X, Chen C, Zhu X, Huang C, et al. Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Nat Commun. 2024;15:296 pubmed publisher

Ludzki A, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar Hmeadi M, et al. Transcriptional determinants of lipid mobilization in human adipocytes. Sci Adv. 2024;10:eadi2689 pubmed publisher

Liu S, Qin Z, Mao Y, Wang N, Zhang W, Wang Y, et al. Pharmacological inhibition of MYC to mitigate chemoresistance in preclinical models of squamous cell carcinoma. Theranostics. 2024;14:622-639 pubmed publisher

Ni H, Wang Y, Yao K, Wang L, HUANG J, Xiao Y, et al. Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice. Nat Commun. 2024;15:1 pubmed publisher

Dai Q, Ye C, Irkliyenko I, Wang Y, Sun H, Gao Y, et al. Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA. Nat Biotechnol. 2024;: pubmed publisher

Schmok J, Jain M, Street L, Tankka A, Schafer D, Her H, et al. Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion. Nat Biotechnol. 2024;: pubmed publisher

Rahman A, Butcko A, Songyekutu E, Granneman J, Mottillo E. Direct effects of adipocyte lipolysis on AMPK through intracellular long-chain acyl-CoA signaling. Sci Rep. 2024;14:19 pubmed publisher

Khan I, Li S, Tao L, Wang C, Ye B, Li H, et al. Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1. Nat Commun. 2024;15:162 pubmed publisher

Yang X, Xu H, Yang X, Wang H, Zou L, Yang Q, et al. Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling. Nat Commun. 2024;15:36 pubmed publisher

Xing T, Li L, Rao X, Zhao J, Chen Y, Ju G, et al. ARID1A deficiency promotes progression and potentiates therapeutic antitumour immunity in hepatitis B virus-related hepatocellular carcinoma. BMC Gastroenterol. 2024;24:11 pubmed publisher

Sun Z, Kantor B, Chiba Falek O. Neuronal-type-specific epigenome editing to decrease SNCA expression: Implications for precision medicine in synucleinopathies. Mol Ther Nucleic Acids. 2024;35:102084 pubmed publisher

Sharma S, Whitehead T, Kotowski M, Ng E, Clarke J, Leitner J, et al. A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells. Life Sci Alliance. 2024;7: pubmed publisher

Wang P, Zhou R, Zhou R, Feng S, Zhao L, Li W, et al. Epidermal growth factor potentiates EGFR(Y992/1173)-mediated therapeutic response of triple negative breast cancer cells to cold atmospheric plasma-activated medium. Redox Biol. 2024;69:102976 pubmed publisher

Akagi Y, Takayama Y, Nihashi Y, Yamashita A, Yoshida R, Miyamoto Y, et al. Functional engineering of human iPSC-derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones. FEBS Open Bio. 2024;14:63-78 pubmed publisher

Al Othman A, Bagrov D, Rozenberg J, Glazova O, Skryabin G, Tchevkina E, et al. Retrovirus-like gag protein Arc/Arg3.1 is involved in extracellular-vesicle-mediated mRNA transfer between glioma cells. Biochim Biophys Acta Gen Subj. 2024;1868:130522 pubmed publisher

Nagaoka K, Bai X, Liu D, Cao K, Mulla J, Ji C, et al. Elevated 2-oxoglutarate antagonizes DNA damage responses in cholangiocarcinoma chemotherapy through regulating aspartate beta-hydroxylase. Cancer Lett. 2024;580:216493 pubmed publisher

Lui V, Hoenig M, Cabrera Martinez B, Baxter R, Garcia Perez J, Bailey O, et al. A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation. J Exp Med. 2024;221: pubmed publisher

Ma X, Mandausch F, Wu Y, Sahoo V, Ma W, Leoni G, et al. Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth. Cell Signal. 2024;113:110917 pubmed publisher

Challa N, Sarkar A, Kapettu S, Phanithi P, Chakrabarti P, Parsa K, et al. TGS1/PIMT regulates pro-inflammatory macrophage mediated paracrine insulin resistance: Crosstalk between macrophages and skeletal muscle cells. Biochim Biophys Acta Mol Basis Dis. 2024;1870:166878 pubmed publisher

Alonso Crisostomo L, Trendell J, Ferraresso M, Bailey S, Ward D, Scurlock Z, et al. Testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment. Int J Cancer. 2024;154:372-388 pubmed publisher

Khurana S, Foltz D. Contribution of CENP-F to FOXM1-mediated discordant centromere and kinetochore transcriptional regulation. bioRxiv. 2023;: pubmed publisher

Tong B, Sun Y. Activation of Young LINE-1 Elements by CRISPRa. Int J Mol Sci. 2023;25: pubmed publisher

Lin K, Hibbert J, Lemens J, Torbey M, Steinert N, Flejsierowicz P, et al. The role of satellite cell-derived TRIM28 in mechanical load- and injury-induced myogenesis. bioRxiv. 2023;: pubmed publisher

Anderson M, Levy A, Dharmasri P, Metzbower S, Blanpied T. Trans-synaptic molecular context of NMDA receptor nanodomains. bioRxiv. 2023;: pubmed publisher

Wang Y, Hollingsworth L, Sangar xe9 L, Paredes Santos T, Krishnamurthy S, Penn B, et al. Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity. bioRxiv. 2023;: pubmed publisher

DiCesare S, Ortega A, Collier G, Daniel S, Thompson K, McCoy M, et al. GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology. bioRxiv. 2023;: pubmed publisher

Pham V, Sertori Finoti L, Cassidy M, Maguire J, Gagne A, Waxman E, et al. A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency. Mol Genet Metab. 2023;:108116 pubmed publisher

Coxon M, Dennis M, Dananberg A, Collins C, Wilson H, Meekma J, et al. An impaired ubiquitin-proteasome system increases APOBEC3A abundance. NAR Cancer. 2023;5:zcad058 pubmed publisher

Annunziata C, Castoldi F, Jan S, Ang H, Ristovska M, Melini S, et al. A versatile method for the identification of senolytic compounds. Cell Stress. 2023;7:105-111 pubmed publisher

Maitz K, Valadez Cosmes P, Raftopoulou S, Kindler O, Kienzl M, Bolouri H, et al. Altered Treg Infiltration after Discoidin Domain Receptor 1 (DDR1) Inhibition and Knockout Promotes Tumor Growth in Lung Adenocarcinoma. Cancers (Basel). 2023;15: pubmed publisher

Huth T, Dreher E, Lemke S, Fritzsche S, Sugiyanto R, Castven D, et al. Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer. Sci Adv. 2023;9:eadh1442 pubmed publisher

Mukashyaka P, Kumar P, Mellert D, Nicholas S, Noorbakhsh J, Brugiolo M, et al. High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos. Nat Commun. 2023;14:8406 pubmed publisher

Xu J, Roe J, Lee E, Tonelli C, Ji K, Younis O, et al. Engrailed-1 Promotes Pancreatic Cancer Metastasis. Adv Sci (Weinh). 2023;:e2308537 pubmed publisher

Lee J, Park N, Nicosia M, Park J, Pruett S, Seo K. Stimulation Strength Determined by Superantigen Dose Controls Subcellular Localization of FOXP3 Isoforms and Suppressive Function of CD4+CD25+FOXP3+ T Cells. J Immunol. 2023;212:421-32 pubmed publisher

Susanto T, Hung V, Levine A, Kerr C, Yoo Y, Chen Y, et al. RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages. bioRxiv. 2023;: pubmed publisher

Wang S, Matsumoto K, Mehlferber M, Zhang G, Aronova M, Yamada K. Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells. Cells Dev. 2023;177:203898 pubmed publisher

Asante Y, Benischke K, Osman I, Ngo Q, Wurth J, Laubscher D, et al. PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution. Nat Commun. 2023;14:8361 pubmed publisher

Chirasani V, Khan M, Malavade J, Dokholyan N, Hoffman B, Campbell S. Molecular basis and cellular functions of vinculin-actin directional catch bonding. Nat Commun. 2023;14:8300 pubmed publisher

Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, et al. USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity. Mol Cancer. 2023;22:204 pubmed publisher

Schmidt R, Ward C, Dajani R, Armour Garb Z, Ota M, Allain V, et al. Base-editing mutagenesis maps alleles to tune human T cell functions. Nature. 2023;: pubmed publisher

Lapak K, Saeidi S, Bok I, Wamsley N, Plutzer I, Bhatt D, et al. Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2. Sci Signal. 2023;16:eadi9018 pubmed publisher

Ye J, Huang Z, Li Q, Li Z, Lan Y, Wang Z, et al. Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders. BMC Med. 2023;21:491 pubmed publisher

Nandy K, Babu D, Rani S, Joshi G, Ijee S, George A, et al. Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression. Sci Rep. 2023;13:21953 pubmed publisher

Zhu Q, Combs M, Liu J, Bai X, Wang W, Herring L, et al. GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis. Nat Commun. 2023;14:8187 pubmed publisher

Broadbent D, McEwan C, Tsang T, Poole D, Naylor B, Price J, et al. The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. bioRxiv. 2023;: pubmed publisher

Pode Shakked N, Slack M, Sundaram N, Schreiber R, McCracken K, Dekel B, et al. RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Nat Commun. 2023;14:8159 pubmed publisher

Manesia J, Maganti H, Almoflehi S, Jahan S, Hasan T, Pasha R, et al. AA2P-mediated DNA demethylation synergizes with stem cell agonists to promote expansion of hematopoietic stem cells. Cell Rep Methods. 2023;3:100663 pubmed publisher

Brandt L, Angelino P, Martinez R, Cristinelli S, Ciuffi A. Sex and Age Impact CD4+ T Cell Susceptibility to HIV In Vitro through Cell Activation Dynamics. Cells. 2023;12: pubmed publisher

Voon H, Hii L, Garvie A, Udugama M, Krug B, Russo C, et al. Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies. Genome Biol. 2023;24:284 pubmed publisher

Wang X, Gao Y, Miao R, Li L, Nanding A, Liu Y, et al. Risk model-guided identification of MTDH expression as a marker for ferroptosis induction therapy in head and neck squamous cell carcinoma. Am J Cancer Res. 2023;13:5236-5253 pubmed

D Alessandro G, Morales Juarez D, Richards S, Nitiss K, Serrano Benítez A, Wang J, et al. RAD54L2 counters TOP2-DNA adducts to promote genome stability. Sci Adv. 2023;9:eadl2108 pubmed publisher

Ramos A, Koch C, Liu Lupo Y, Hellinger R, Kyung T, Abbott K, et al. Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening. Nat Commun. 2023;14:8048 pubmed publisher

Zhang S, Zeng L, Su B, Yang G, Wang J, Ming S, et al. The glycoprotein 5 of porcine reproductive and respiratory syndrome virus stimulates mitochondrial ROS to facilitate viral replication. MBio. 2023;14:e0265123 pubmed publisher

Yuan M, Peng L, Huang D, Gavin A, Luan F, Tran J, et al. Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4. bioRxiv. 2023;: pubmed publisher

Wang Y, Armendariz D, Wang L, Zhao H, Xie S, Hon G. Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes. bioRxiv. 2023;: pubmed publisher

Siddiqui A, Saxena A, Echols J, Havasi V, Fu L, Keeling K. RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay. Heliyon. 2023;9:e22281 pubmed publisher

Somborac T, Lutfullahoglu Bal G, Fatima K, Vihinen H, Paatero A, Jokitalo E, et al. The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved. PLoS ONE. 2023;18:e0295047 pubmed publisher

Xue G, Xie J, Hinterndorfer M, Cigler M, D xf6 tsch L, Imrichová H, et al. Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype. Nat Commun. 2023;14:7908 pubmed publisher

Nemergut M, Pluskal D, Horáčková J, Sustrova T, Tulis J, Bárta T, et al. Illuminating the mechanism and allosteric behavior of NanoLuc luciferase. Nat Commun. 2023;14:7864 pubmed publisher

Chen K, Tang F, Du B, Yue Z, Jiao L, Ding X, et al. Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism. MedComm (2020). 2023;4:e429 pubmed publisher

Hao W, Chen Z, Tang J, Yang R, Gao W, Xu H. hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner. J Transl Med. 2023;21:861 pubmed publisher

Ji Y, Zhang W, Shen K, Su R, Liu X, Ma Z, et al. The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer. Nat Commun. 2023;14:7794 pubmed publisher

Bond A, Fiaz S, Rollins K, Nario J, Rosen S, Granados A, et al. Prior Fc Receptor activation primes macrophages for increased sensitivity to IgG via long term and short term mechanisms. bioRxiv. 2023;: pubmed publisher

Galvin R, Jena S, Maeser D, Gruener R, Huang R. Revealing Pan-Histology Immunomodulatory Targets in Pediatric Central Nervous System Tumors. Cancers (Basel). 2023;15: pubmed publisher

Xie J, Mo T, Li R, Zhang H, Liang G, Ma T, et al. The m7G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling. Cancers (Basel). 2023;15: pubmed publisher

Boichuk S, Dunaev P, Skripova V, Galembikova A, Bikinieva F, Shagimardanova E, et al. Unraveling the Mechanisms of Sensitivity to Anti-FGF Therapies in Imatinib-Resistant Gastrointestinal Stromal Tumors (GIST) Lacking Secondary KIT Mutations. Cancers (Basel). 2023;15: pubmed publisher

Mes xe9 n Porras S, Rojas C xe9 spedes A, Molina Mora J, Vega Baudrit J, Siles F, Quiros S, et al. Sphingolipid-Based Synergistic Interactions to Enhance Chemosensitivity in Lung Cancer Cells. Cells. 2023;12: pubmed publisher

Wright C, Gordon E, Cooper S. Genomic analysis reveals HDAC1 regulates clinically relevant transcriptional programs in Pancreatic cancer. BMC Cancer. 2023;23:1137 pubmed publisher

Barroso Gomila O, Merino Cacho L, Muratore V, Pérez C, Taibi V, Maspero E, et al. BioE3 identifies specific substrates of ubiquitin E3 ligases. Nat Commun. 2023;14:7656 pubmed publisher

Morgan M, Mohammad Parast S, Iwanaszko M, Aoi Y, Yoo D, Dumar Z, et al. ELOA3: A primate-specific RNA polymerase II elongation factor encoded by a tandem repeat gene cluster. Sci Adv. 2023;9:eadj1261 pubmed publisher

Jin L, Sullivan H, Zhu M, Lea N, Lavin T, Fu X, et al. Third-generation rabies viral vectors allow nontoxic retrograde targeting of projection neurons with greatly increased efficiency. Cell Rep Methods. 2023;3:100644 pubmed publisher

Yang Z, Xiang Q, Nicholas J. Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2. PLoS Pathog. 2023;19:e1011806 pubmed publisher

Sharma N, Kessler P, Sen G. Cell-type-specific need of Ddx3 and PACT for interferon induction by RNA viruses. J Virol. 2023;97:e0130423 pubmed publisher

Qin N, Paisana E, Picard D, Leprivier G, Langini M, Cust xf3 dia C, et al. The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma. J Neurooncol. 2023;165:329-342 pubmed publisher

Zhang M, Lv L, Luo H, Cai H, Yu L, Jiang Y, et al. The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity. Vet Res. 2023;54:106 pubmed publisher

Searcy M, Larsen R, Stevens B, Zhang Y, Jin H, Drummond C, et al. PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors. Nat Commun. 2023;14:7291 pubmed publisher

Liu S, Wang C, Lin R, Ding W, Roy G, Wang H, et al. Super-enhancer driven SOX2 promotes tumor formation by chromatin re-organization in nasopharyngeal carcinoma. EBioMedicine. 2023;98:104870 pubmed publisher

Li C, Fu J, Shao S, Luo Z. Legionella pneumophila exploits the endo-lysosomal network for phagosome biogenesis by co-opting SUMOylated Rab7. bioRxiv. 2023;: pubmed publisher

Swaby C, Yeung Luk B, Thapa S, Nishida K, Wally A, Ghosh B, et al. Decreased fucosylation impacts epithelial integrity and increases risk for COPD. bioRxiv. 2023;: pubmed publisher

Rehbein S, Possmayer A, Bozkurt S, Lotsch C, Gerstmeier J, Bürger M, et al. Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells. Cancers (Basel). 2023;15: pubmed publisher

Greulich B, Rajendran S, Downing N, Nicholas T, Hollenhorst P. A complex with poly(A)-binding protein and EWS facilitates the transcriptional function of oncogenic ETS transcription factors in prostate cells. J Biol Chem. 2023;299:105453 pubmed publisher

Valenzuela Valderas K, Farrashzadeh E, Chang Y, Shi Y, Raudonis R, Leung B, et al. RACK1 promotes Shigella flexneri actin-mediated invasion, motility, and cell-to-cell spreading. iScience. 2023;26:108216 pubmed publisher

Long J, Chen X, Shen Y, Lei Y, Mu L, Wang Z, et al. A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment. Cell Rep Med. 2023;4:101286 pubmed publisher

Chong A, Vandana J, Jeng G, Li G, Meng Z, Duan X, et al. Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Nat Chem Biol. 2023;: pubmed publisher

Haydo A, Wehle A, Herold Mende C, K xf6 gel D, Pampaloni F, Linder B. Combining organotypic tissue culture with light-sheet microscopy (OTCxLSFM) to study glioma invasion. EMBO Rep. 2023;24:e56964 pubmed publisher

Kim S, Kiser P, Asfaha S, DeKoter R, Dick F. EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells. EMBO J. 2023;42:e114462 pubmed publisher

Janev A, Ramuta T, Jerman U, Obradovi x107 H, Kamen x161 ek U, x10c ema x17e ar M, et al. Human amniotic membrane inhibits migration and invasion of muscle-invasive bladder cancer urothelial cells by downregulating the FAK/PI3K/Akt/mTOR signalling pathway. Sci Rep. 2023;13:19227 pubmed publisher

H xf6 pfner D, Cichy A, Pogenberg V, Krisp C, Mezouar S, Bach N, et al. The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3. Commun Biol. 2023;6:1124 pubmed publisher

Mahieu C, MANCINI A, Vikram E, Planells Palop V, Joseph N, Tward A. ORAOV1, CCND1, and MIR548K are the driver oncogenes of the 11q13 amplicon in squamous cell carcinoma. Mol Cancer Res. 2023;: pubmed publisher

Sempert K, Shohayeb B, Lanoue V, O Brien E, Flores C, Cooper H. RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling. Front Mol Neurosci. 2023;16:1253801 pubmed publisher

Makri Pistikou A, Cremers G, Nathalia B, Meuleman T, B xf6 gels B, Eijkens B, et al. Engineering a scalable and orthogonal platform for synthetic communication in mammalian cells. Nat Commun. 2023;14:7001 pubmed publisher

Tan I, Perez A, Lew R, Sun X, Baldwin A, Zhu Y, et al. Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis. Cell Rep. 2023;42:113339 pubmed publisher

Wang Y, Hao Y, Shen M, Han X, Wang Y, Chen S, et al. The Expression of LDL-R in CD8+ T Cells Serves as an Early Assessment Parameter for the Production of TCR-T Cells. In Vivo. 2023;37:2480-2489 pubmed publisher

Qian C, Yang Q, Rotinen M, Huang R, Kim H, Gallent B, et al. ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer. bioRxiv. 2023;: pubmed publisher

Wang Z, Luo M, Liang Q, Zhao K, Hu Y, Wang W, et al. Landscape of enhancer disruption and functional screen in melanoma cells. Genome Biol. 2023;24:248 pubmed publisher

Mondesir J, Ghisi M, Poillet L, Bossong R, Kepp O, Kroemer G, et al. AMPK activation induces immunogenic cell death in AML. Blood Adv. 2023;7:7585-7596 pubmed publisher

Vaz T, Rodrigues A, Coroadinha A. Exploring nutrient supplementation and bioprocess optimization to improve the production of lentiviral vectors in serum-free medium suspension cultures. Biotechnol J. 2023;:e2300212 pubmed publisher

xd6 ktem M, Mastrobattista E, de Jong O. Amphipathic Cell-Penetrating Peptide-Aided Delivery of Cas9 RNP for In Vitro Gene Editing and Correction. Pharmaceutics. 2023;15: pubmed publisher

G xf3 mez Moreno A, San Sebastian E, Moya J, Gomoll xf3 n Zueco P, Isola S, Vales x, et al. Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells. Pharmaceutics. 2023;15: pubmed publisher

Li J, Brachtlova T, van der Meulen Muileman I, Kleerebezem S, Liu C, Li P, et al. Human Non-Small Cell Lung Cancer-Chicken Embryo Chorioallantoic Membrane Tumor Models for Experimental Cancer Treatments. Int J Mol Sci. 2023;24: pubmed publisher

Bekas N, Samiotaki M, Papathanasiou M, Mokos P, Pseftogas A, Xanthopoulos K, et al. Inactivation of Tumor Suppressor CYLD Inhibits Fibroblast Reprogramming to Pluripotency. Cancers (Basel). 2023;15: pubmed publisher

Roennfeldt A, Allen T, Trowbridge B, Beard M, Whitelaw M, Russell D, et al. NanoFIRE: A NanoLuciferase and Fluorescent Integrated Reporter Element for Robust and Sensitive Investigation of HIF and Other Signalling Pathways. Biomolecules. 2023;13: pubmed publisher

Zhou J, Cattoglio C, Shao Y, Tirumala H, Vetralla C, Bajikar S, et al. A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Genes Dev. 2023;37:883-900 pubmed publisher

Valiullina A, Zmievskaya E, Ganeeva I, Zhuravleva M, Garanina E, Rizvanov A, et al. Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line. Mol Biol Res Commun. 2023;12:139-148 pubmed publisher

Fala M, Ros S, Sawle A, Rao J, Tsyben A, Tronci L, et al. The role of branched-chain aminotransferase 1 in driving glioblastoma cell proliferation and invasion varies with tumor subtype. Neurooncol Adv. 2023;5:vdad120 pubmed publisher

Tsai L, Peng M, Chang C, Wen L, Liu L, Liang X, et al. ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells. Cell Biosci. 2023;13:193 pubmed publisher

Bie N, Yong T, Wei Z, Liang Q, Zhang X, Li S, et al. Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy. Signal Transduct Target Ther. 2023;8:408 pubmed publisher

Mohammadkhani N, Rahimpour A, Hoseinpoor R, Rajabibazl M. Development of Stable CHO-K1 Cell Lines Overexpressing Full-Length Human CD20 Antigen. Iran Biomed J. 2023;27:269-79 pubmed publisher

Boeszoermenyi A, Bernaleau L, Chen X, Kartnig F, Xie M, Zhang H, et al. A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun. 2023;14:6626 pubmed publisher

Dubaić M, Peskova L, Hampl M, Weissová K, Celiker C, Shylo N, et al. Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Life Sci Alliance. 2023;6: pubmed publisher

Gao Z, Wang M, Smith A, Boyes J. YY1 Binding to Regulatory Elements That Lack Enhancer Activity Promotes Locus Folding and Gene Activation. J Mol Biol. 2023;435:168315 pubmed publisher

Nan Y, Liu S, Luo Q, Wu X, Zhao P, Chang W, et al. m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation. Cell Rep. 2023;42:113273 pubmed publisher

Lee D, Ahn H, Sim H, Choi E, Choi S, Jo Y, et al. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. J Exp Clin Cancer Res. 2023;42:272 pubmed publisher

Lee J, Shores K, Breithaupt J, Lee C, Fodera D, Kwon J, et al. PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system. APL Bioeng. 2023;7:046103 pubmed publisher

Sastre D, Zafar F, Torres C, Piper D, Kirik D, Sanders L, et al. Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson's disease. Sci Rep. 2023;13:17796 pubmed publisher

Waters C, Angenent S, Altschuler S, Wu L. A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit. Cell Rep. 2023;42:113260 pubmed publisher

Kas S, Mundra P, Smith D, Marais R. Functional classification of DDOST variants of uncertain clinical significance in congenital disorders of glycosylation. Sci Rep. 2023;13:17648 pubmed publisher

Conway J, Isomursu A, Follain G, H xe4 rm xe4 V, Jou Oll xe9 E, Pasquier N, et al. Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling. Proc Natl Acad Sci U S A. 2023;120:e2304288120 pubmed publisher

Huang M, Xia Y, Li K, Shao F, Feng Z, Li T, et al. Carcinogen exposure enhances cancer immunogenicity by blocking the development of an immunosuppressive tumor microenvironment. J Clin Invest. 2023;133: pubmed publisher

Hong S, Lee S, Park J, Hong M, Yoon J, Lee H, et al. miR-199a and miR-199b facilitate diffuse gastric cancer progression by targeting Frizzled-6. Sci Rep. 2023;13:17480 pubmed publisher

Kim Y, Li C, Gu C, Fang Y, Tycksen E, Puri A, et al. MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice. Nat Commun. 2023;14:6493 pubmed publisher

Fan H, Liu W, Zeng Y, Zhou Y, Gao M, Yang L, et al. DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway. Commun Biol. 2023;6:1041 pubmed publisher

Kovacs M, Vallette M, Wiertsema P, Dingli F, Loew D, Nader G, et al. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Mol Cell. 2023;83:3659-3668.e10 pubmed publisher

Zhu B, Fisher E, Li L, Zhong P, Yan Z, Feng J. PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes. Stem Cell Reports. 2023;18:2268-2282 pubmed publisher

Reichlmeir M, Canet Pons J, Koepf G, Nurieva W, Duecker R, Doering C, et al. In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While Downregulations Affect Prominently Itpr1, Usp2 and Non-Coding RNA. Cells. 2023;12: pubmed publisher

Gonzalez H, Narasipura S, Shull T, Shetty A, Teppen T, Naqib A, et al. An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes. Cells. 2023;12: pubmed publisher

Al Khayyat W, Pirkkanen J, Dougherty J, Laframboise T, Dickinson N, Khaper N, et al. Overexpression of FRA1 (FOSL1) Leads to Global Transcriptional Perturbations, Reduced Cellular Adhesion and Altered Cell Cycle Progression. Cells. 2023;12: pubmed publisher

Otani Y, Yoshikawa S, Nagao K, Tanaka T, Toyooka S, Fujimura A. Connective tissue mast cells store and release noradrenaline. J Physiol Sci. 2023;73:24 pubmed publisher

Van Campenhout R, De Groof T, Kadam P, Kwak B, Muyldermans S, Devoogdt N, et al. Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury. J Nanobiotechnology. 2023;21:371 pubmed publisher

Silva Barcelos E, Rompietti C, Adamo F, Dorillo E, De Falco F, Del Papa B, et al. NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential. Front Oncol. 2023;13:1218989 pubmed publisher

Liu N, Zhang J, Chen W, Ma W, Wu T. The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression. J Exp Clin Cancer Res. 2023;42:263 pubmed publisher

Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, et al. FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes. Nat Commun. 2023;14:6344 pubmed publisher

Sheehan C, Marayati B, Bhatia J, Meyer K. In situ visualization of m6A sites in cellular mRNAs. Nucleic Acids Res. 2023;51:e101 pubmed publisher

Benton A, Terwilliger E, Moriarty N, Liu B, Murphy A, Maluvac H, et al. Target gene regulatory network of miR-497 in angiosarcoma. bioRxiv. 2023;: pubmed publisher

Pham A, Mani M, Wang X, Vafabakhsh R. The Physical Biology of Nucleolus Disassembly. bioRxiv. 2023;: pubmed publisher

Doxtater K, Tripathi M, Sekhri R, Hafeez B, Khan S, Zafar N, et al. MUC13 drives cancer aggressiveness and metastasis through the YAP1-dependent pathway. Life Sci Alliance. 2023;6: pubmed publisher

Williams C, Brown R, Zhao Y, Wang J, Chen Z, Blunt K, et al. MTGR1 is required to maintain small intestinal stem cell populations. Res Sq. 2023;: pubmed publisher

Cerda Smith C, Hutchinson H, Liu A, Goel V, Sept C, Kim H, et al. Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization. bioRxiv. 2023;: pubmed publisher

Murugan S, Nandi B, Mazumdar V, Joshi K, Nandini P, Namani S, et al. Outer membrane protein 25 of Brucella suppresses TLR-mediated expression of proinflammatory cytokines through degradation of TLRs and adaptor proteins. J Biol Chem. 2023;299:105309 pubmed publisher

Guo S, Xu Z, Feng Q, Zhang H, Yu D, Li B, et al. Molecular mechanism by which RRM2-inhibitor (cholagogue osalmid) plus bafilomycin A1 cause autophagic cell death in multiple myeloma. Arch Biochem Biophys. 2023;747:109771 pubmed publisher

Zhang W, Lu C, Nakamoto M, Tsai C, Roy A, Lee C, et al. Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions. Nat Cell Biol. 2023;25:1453-1464 pubmed publisher

Shi Y, Simpson S, Ahmed S, Chen Y, Tavakoli Tameh A, Janaka S, et al. The Antiviral Factor SERINC5 Impairs the Expression of Non-Self-DNA. Viruses. 2023;15: pubmed publisher

Akhtar J, Imran M, Wang G. CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells. Int J Mol Sci. 2023;24: pubmed publisher

Enz L, Winkler A, Wrzos C, Dasen B, Nessler S, Stadelmann C, et al. An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex. Int J Mol Sci. 2023;24: pubmed publisher

Domma A, Henderson L, Goodrum F, Moorman N, Kamil J. Human cytomegalovirus attenuates AKT activity by destabilizing insulin receptor substrate proteins. J Virol. 2023;97:e0056323 pubmed publisher

Khaleafi R, Železnjak J, Cordela S, Drucker S, Rovis T, Jonjic S, et al. Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Front Immunol. 2023;14:1231782 pubmed publisher

Han J, Xie C, Liu B, Wang Y, Pang R, Bi W, et al. Tetraspanin 1 regulates papillary thyroid tumor growth and metastasis through c-Myc-mediated glycolysis. Cancer Sci. 2023;114:4535-4547 pubmed publisher

Kaur B, Sharma P, Chatterjee B, Bissa B, Nattarayan V, Ramasamy S, et al. Defective quality control autophagy in Hyperhomocysteinemia promotes ER stress and consequent neuronal apoptosis through proteotoxicity. Cell Commun Signal. 2023;21:258 pubmed publisher

Xu Z, Sziráki A, Lee J, Zhou W, Cao J. Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens. Nat Biotechnol. 2023;: pubmed publisher

Shorthouse D, Zhuang L, Rahrmann E, Kosmidou C, Wickham Rahrmann K, Hall M, et al. KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas. Life Sci Alliance. 2023;6: pubmed publisher

Childress K, Cencer C, Tyska M, Lacy D. Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB. MBio. 2023;14:e0185723 pubmed publisher

Nano P, Fazzari E, Azizad D, Nguyen C, Wang S, Kan R, et al. A Meta-Atlas of the Developing Human Cortex Identifies Modules Driving Cell Subtype Specification. bioRxiv. 2023;: pubmed publisher

Rivera J, Weng W, Huang H, Rao S, Herring B, Arnold D. ATLAS: A rationally designed anterograde transsynaptic tracer. bioRxiv. 2023;: pubmed publisher

Schertzer M, Stirn A, Isaev K, Pereira L, Das A, Harbison C, et al. Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox. bioRxiv. 2023;: pubmed publisher

Yu Q, Van Minsel P, Galle E, Thienpont B. GiRAFR improves gRNA detection and annotation in single-cell CRISPR screens. Commun Biol. 2023;6:975 pubmed publisher

Chan W, Williams J, Sorathia K, Pray B, Abusaleh K, Bian Z, et al. A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models. Exp Hematol Oncol. 2023;12:79 pubmed publisher

Rohatgi N, Zou W, Li Y, Cho K, Collins P, Tycksen E, et al. BAP1 promotes osteoclast function by metabolic reprogramming. Nat Commun. 2023;14:5923 pubmed publisher

Ren R, Hua Y, Wang H. Protocol to capture transcription factor-mediated 3D chromatin interactions using affinity tag-based BL-HiChIP. STAR Protoc. 2023;4:102589 pubmed publisher

Barik G, Sahay O, Mukhopadhyay A, Manne R, Islam S, Roy A, et al. FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis. Cell Death Dis. 2023;14:623 pubmed publisher

Kugler E, Madiwale S, Yong D, Thoms J, Birger Y, Sykes D, et al. The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Nat Commun. 2023;14:5871 pubmed publisher

Dharmasri P, Levy A, Blanpied T. Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons. bioRxiv. 2023;: pubmed publisher

Tian L, Li H, Zhao P, Liu Y, Lu Y, Zhong R, et al. C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages. iScience. 2023;26:107771 pubmed publisher

Mukhopadhyay S, Huang H, Lin Z, Ranieri M, Li S, Sahu S, et al. Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy. Cancer Res. 2023;83:4095-4111 pubmed publisher

Lee W, Zamudio Ochoa A, Buchel G, Podlesniy P, Martí Gutiérrez N, Puigr xf2 s M, et al. Molecular basis for maternal inheritance of human mitochondrial DNA. Nat Genet. 2023;55:1632-1639 pubmed publisher

Belliveau N, Footer M, Akdo x1e7 an E, van Loon A, Collins S, Theriot J. Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils. Nat Commun. 2023;14:5770 pubmed publisher

Yu D, Zhao J, Lee E, Kim D, Mahapatra R, Rose E, et al. GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. J Clin Invest. 2023;133: pubmed publisher

Yousefi Najafabadi Z, Mehmandoostli Z, Asgari Y, Kaboli S, Falak R, Kardar G. Reversing T Cell Exhaustion by Converting Membrane PD-1 to Its Soluble form in Jurkat Cells; Applying The CRISPR/Cas9 Exon Skipping Strategy. Cell J. 2023;25:633-644 pubmed publisher

Pan H, Cheng X, Rodr xed guez P, Zhang X, Chung I, Jin V, et al. An essential signaling function of cytoplasmic NELFB is independent of RNA polymerase II pausing. J Biol Chem. 2023;299:105259 pubmed publisher

Malnar x10c rnigoj M, x10c er x10d ek U, Yin X, Ho M, Repič Lampret B, Neumann M, et al. Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA. Nat Commun. 2023;14:5764 pubmed publisher

Cui Y, Miao Y, Cao L, Guo L, Cui Y, Yan C, et al. Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. Nat Commun. 2023;14:5740 pubmed publisher

K xf6 rner M, Meyer S, Marincola G, Kern M, Grimm C, Schuelein Voelk C, et al. The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. elife. 2023;12: pubmed publisher

Gao Z, Smith A, Scott J, Bevington S, Boyes J. Temporal analyses reveal a pivotal role for sense and antisense enhancer RNAs in coordinate immunoglobulin lambda locus activation. Nucleic Acids Res. 2023;51:10344-10363 pubmed publisher

Kim H, Grimes S, Chen T, Sathe A, Lau B, Hwang G, et al. Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells. Nat Biotechnol. 2023;: pubmed publisher

Gong N, Han X, Xue L, El Mayta R, Metzloff A, Billingsley M, et al. In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity. Nat Mater. 2023;22:1571-1580 pubmed publisher

Zeng H, Yuan Q, Peng F, Ma D, Lingineni A, Chee K, et al. A split and inducible adenine base editor for precise in vivo base editing. Nat Commun. 2023;14:5573 pubmed publisher

Neely V, Manchikalapudi A, Nguyen K, Dalton K, Hu B, Koblinski J, et al. Targeting Oncogenic Mutant p53 and BCL-2 for Small Cell Lung Cancer Treatment. Int J Mol Sci. 2023;24: pubmed publisher

Lee T, Hunter F, Tsai P, Print C, Wilson W, Jamieson S. Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens. Cancer Gene Ther. 2023;30:1610-1623 pubmed publisher

McAloney C, Makkawi R, Budhathoki Y, Cannon M, Franz E, Gross A, et al. Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. Cell Oncol (Dordr). 2023;: pubmed publisher

Dou Y, Chen R, Liu S, Lee Y, Jing J, Liu X, et al. Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy. Nat Commun. 2023;14:5461 pubmed publisher

Lethier M, Huard K, Hons M, Favier A, Brutscher B, Boeri Erba E, et al. Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface. Life Sci Alliance. 2023;6: pubmed publisher

Xu D, Forbes A, Cohen S, Palladino A, Karadimitriou T, Khurana E. Recapitulation of patient-specific 3D chromatin conformation using machine learning. Cell Rep Methods. 2023;3:100578 pubmed publisher

Irollo E, Nash B, Luchetta J, Brandimarti R, Meucci O. The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain. J Neuroimmune Pharmacol. 2023;18:495-508 pubmed publisher

Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang J, et al. SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1. J Clin Invest. 2023;133: pubmed publisher

Li K, Cardenas Lizana P, Kellner A, Yuan Z, Ahn E, Lyu J, et al. Mechanical force regulates ligand binding and function of PD-1. bioRxiv. 2023;: pubmed publisher

Capauto D, Wang Y, Wu F, Norton S, Mariani J, Inoue F, et al. Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids. bioRxiv. 2023;: pubmed publisher

Zhang T, Leng Y, Duan M, Li Z, Ma Y, Huang C, et al. LncRNA GAS5-hnRNPK axis inhibited ovarian cancer progression via inhibition of AKT signaling in ovarian cancer cells. Discov Oncol. 2023;14:157 pubmed publisher

Luo H, Lv L, Yi J, Zhou Y, Liu C. Establishment of Replication Deficient Vesicular Stomatitis Virus for Studies of PEDV Spike-Mediated Cell Entry and Its Inhibition. Microorganisms. 2023;11: pubmed publisher

Yang S, Wang Y, Yu F, Cheng R, Zhang Y, Zhou D, et al. Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Nat Commun. 2023;14:5186 pubmed publisher

Gsottberger F, Meier C, Ammon A, Parker S, Wendland K, George R, et al. Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response. Cell Death Dis. 2023;14:561 pubmed publisher

Sporbeck K, Haas M, Pastor Maldonado C, Sch xfc ssele D, Hunter C, Takacs Z, et al. The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension. Commun Biol. 2023;6:872 pubmed publisher

Einig E, Jin C, Andrioletti V, Macek B, Popov N. RNAPII-dependent ATM signaling at collisions with replication forks. Nat Commun. 2023;14:5147 pubmed publisher

Hu Y, Liu L, Chen Y, Zhang X, Zhou H, Hu S, et al. Cancer-cell-secreted miR-204-5p induces leptin signalling pathway in white adipose tissue to promote cancer-associated cachexia. Nat Commun. 2023;14:5179 pubmed publisher

Halawani D, Wang Y, Ramakrishnan A, Estill M, He X, Shen L, et al. Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons. Nat Commun. 2023;14:5165 pubmed publisher

Weng M, Hu H, Graus M, Tan D, Gao Y, Ren S, et al. An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming. Sci Adv. 2023;9:eadh2501 pubmed publisher

Sugiokto F, Saiada F, Zhang K, Li R. SUMOylation of the m6A reader YTHDF2 by PIAS1 promotes viral RNA decay to restrict EBV replication. bioRxiv. 2023;: pubmed publisher

Ramezani M, Bauman J, Singh A, Weisbart E, Yong J, Lozada M, et al. A genome-wide atlas of human cell morphology. bioRxiv. 2023;: pubmed publisher

Hu H, Ho D, Tan D, MacCarthy C, Yu C, Weng M, et al. Evaluation of the determinants for improved pluripotency induction and maintenance by engineered SOX17. Nucleic Acids Res. 2023;51:8934-8956 pubmed publisher

Liu S, Heum xfc ller S, Hossinger A, M xfc ller S, Buravlova O, Lichtenthaler S, et al. Reactivated endogenous retroviruses promote protein aggregate spreading. Nat Commun. 2023;14:5034 pubmed publisher

Worboys J, Vowell K, Hare R, Ambrose A, Bertuzzi M, Conner M, et al. TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation. Nat Commun. 2023;14:5016 pubmed publisher

Duplaquet L, Li Y, Booker M, Xie Y, Olsen S, Patel R, et al. KDM6A epigenetically regulates subtype plasticity in small cell lung cancer. Nat Cell Biol. 2023;25:1346-1358 pubmed publisher

Enders L, Siklos M, Borggr xe4 fe J, Gaussmann S, Koren A, Malik M, et al. Pharmacological perturbation of the phase-separating protein SMNDC1. Nat Commun. 2023;14:4504 pubmed publisher

Lara Astiaso D, Go xf1 i Salaverri A, Mendieta Esteban J, Narayan N, Del Valle C, Gross T, et al. In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis. Nat Genet. 2023;55:1542-1554 pubmed publisher

Nikolatou K, Sandilands E, Rom xe1 n Fern xe1 ndez A, Cumming E, Freckmann E, Lilla S, et al. PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO J. 2023;42:e113987 pubmed publisher

Oztürk K, Panwala R, Sheen J, Ford K, Payne N, Zhang D, et al. Interface-guided phenotyping of coding variants in the transcription factor RUNX1 with SEUSS. bioRxiv. 2023;: pubmed publisher

Quiroz E, Kim S, Gautam L, Borok Z, Kintner C, Ryan A. RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. bioRxiv. 2023;: pubmed publisher

de Caestecker C, Macara I. A Size Filter Regulates Apical Protein Sorting. Res Sq. 2023;: pubmed publisher

Park J, Luo Y, Park J, Kim S, Hong Y, Lim Y, et al. Downregulation of DNA methylation enhances differentiation of THP-1 cells and induces M1 polarization of differentiated macrophages. Sci Rep. 2023;13:13132 pubmed publisher

Chen W, Wu C, Liu Y, Zhuo G, Wang Y, Chen Y, et al. Elafin as a Prognostic Marker in Esophageal Squamous Cell Carcinoma: A Pilot Study Using Three-Dimensional Imaging and Genomic Profiling. Cancers (Basel). 2023;15: pubmed publisher

Klotz D, Schwarz F, Dubrovska A, Schuster K, Theis M, Kr xfc ger A, et al. Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer. Cancers (Basel). 2023;15: pubmed publisher

Wu J, Wang X, Zhang M, Mathews P, Kang Y. RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect. Cells. 2023;12: pubmed publisher

Varberg K, Domínguez E, Koseva B, Varberg J, McNally R, Moreno Irusta A, et al. Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape. Nat Commun. 2023;14:4826 pubmed publisher

Venkatarangan V, Zhang W, Yang X, Thoene J, Hahn S, Li M. ER-associated degradation in cystinosis pathogenesis and the prospects of precision medicine. J Clin Invest. 2023;133: pubmed publisher

Zagnoli Vieira G, Brazina J, Van Den Bogaert K, Huybrechts W, Molenaers G, Caldecott K, et al. Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemia. Hum Genet. 2023;142:1417-1427 pubmed publisher

Leighton G, Shang S, Hageman S, Ginder G, Williams D. Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing. Proc Natl Acad Sci U S A. 2023;120:e2307287120 pubmed publisher

Zhou H, Zhou L, Guan Q, Hou X, Wang C, Liu L, et al. Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells. Commun Biol. 2023;6:805 pubmed publisher

Salas Lloret D, Jansen N, Nagamalleswari E, van der Meulen C, Gracheva E, de Ru A, et al. SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome. Sci Adv. 2023;9:eadh2073 pubmed publisher

Koban F, Freissmuth M. The cell cycle protein MAD2 facilitates endocytosis of the serotonin transporter in the neuronal soma. EMBO Rep. 2023;24:e53408 pubmed publisher

Wang C, Yang K, Liu X, Wang S, Song M, Belmonte J, et al. MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer. Research (Wash D C). 2023;6:0192 pubmed publisher

Abdelaziz M, Raftery M, Weihs J, Bielawski O, Edel R, K xf6 ppke J, et al. Early protective effect of a ("pan") coronavirus vaccine (PanCoVac) in Roborovski dwarf hamsters after single-low dose intranasal administration. Front Immunol. 2023;14:1166765 pubmed publisher

Cox J, Jennings M, Lenahan C, Manion M, Courville S, Blazeck J. Rational engineering of an improved adenosine deaminase 2 enzyme for weaponizing T-cell therapies. Immunooncol Technol. 2023;19:100394 pubmed publisher

Kanai A, Nishida Y, Iwamoto T, Yokota M, Aoyama S, Ueki K, et al. Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter. Biochem Biophys Res Commun. 2023;676:132-140 pubmed publisher

Fan T, Winnike J, Al Attar A, Belshoff A, Lorkiewicz P, Tan J, et al. Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer. Metabolites. 2023;13: pubmed publisher

Hong S, Kim K, Ahn S. Inhibition of GLI Transcriptional Activity and Prostate Cancer Cell Growth and Proliferation by DAX1. Curr Issues Mol Biol. 2023;45:5347-5361 pubmed publisher

Betriu S, Rovira J, Arana C, Garc xed a Busquets A, Matilla Martinez M, Ramírez Bajo M, et al. Chimeric HLA antibody receptor T cells for targeted therapy of antibody-mediated rejection in transplantation. HLA. 2023;: pubmed publisher

Prislusky M, Lam J, Contreras V, Ng M, Chamberlain M, Fields M, et al. The Septin Cytoskeleton is Required for Plasma Membrane Repair. bioRxiv. 2023;: pubmed publisher

Serebrenik Y, Mani D, Maujean T, Burslem G, Shalem O. Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics. bioRxiv. 2023;: pubmed publisher

Rashidfarrokhi A, Pillai R, Hao Y, Wu W, Karadal Ferrena B, Dimitriadoy S, et al. Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth. bioRxiv. 2023;: pubmed publisher

Ren X, Yang H, Nierenberg J, Sun Y, Chen J, Beaman C, et al. High throughput PRIME editing screens identify functional DNA variants in the human genome. bioRxiv. 2023;: pubmed publisher

Lin C, Chang T, Wang Y, Guo L, Gao Y, Bikorimana E, et al. Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Res Sq. 2023;: pubmed publisher

Kim Y, Kim J, Lee D, Choi J, Park J, Lee H, et al. T Cells Expressing CAR Equipped With Extracellular Domain of BTLA Are Effective Against HVEM-over-expressing Melanoma Cell Lines. Anticancer Res. 2023;43:3419-3427 pubmed publisher

Pal D, Lin Y, Zhan H, Banerjee T, Kuhn J, Providence S, et al. Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement. Front Cell Dev Biol. 2023;11:1195806 pubmed publisher

Nguyen T, Rajakannu P, Pham M, Weman L, Jucht A, Buri M, et al. Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA-repair protein N-methylpurine DNA glycosylase (MPG). Mol Oncol. 2023;: pubmed publisher

Kumar S, Stainer A, Dubrulle J, Simpkins C, Cooper J. Cas phosphorylation regulates focal adhesion assembly. elife. 2023;12: pubmed publisher

Li H, Bartke R, Zhao L, Verma Y, Horacek A, Rechav Ben Natan A, et al. Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells. Nat Biomed Eng. 2023;: pubmed publisher

Sharma R, Earla B, Baidoo K, Zeiger M, Madigan J, Escorcia F, et al. Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model. Mol Cancer Ther. 2023;: pubmed publisher

Steadman K, You S, Srinivas D, Mouakkad L, Yan Y, Kim M, et al. Autonomous action and cooperativity between the ONECUT2 transcription factor and its 3' untranslated region. Front Cell Dev Biol. 2023;11:1206259 pubmed publisher

Long Y, Ren Y, Wei Q, Mobet Y, Liu Y, Zhao H, et al. NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression. Int J Med Sci. 2023;20:1079-1090 pubmed publisher

Ali S, Rivera M, Ward J, Keshavarz Moore E, Mason C, Nesbeth D. Serum-free lentiviral vector production is compatible with medium-resident nuclease activity arising from adherent HEK293T host cells engineered with a nuclease-encoding transgene. Heliyon. 2023;9:e17067 pubmed publisher

Joshi P, Sadre S, Guo X, McCoy J, Mootha V. Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells. J Biol Chem. 2023;:105075 pubmed publisher

Ding Z, Yang J, Wu B, Wu Y, Guo F. Long non-coding RNA CCHE1 modulates LDHA-mediated glycolysis and confers chemoresistance to melanoma cells. Cancer Metab. 2023;11:10 pubmed publisher

Nasehi L, Abdolhossein Zadeh B, Rahimi H, Hossein Ghahremani M. Radio-immunotherapy by 188Re-antiCD20 and stable silencing of IGF-IR in Raji cells, new insight in treatment of lymphoma. Gene. 2023;882:147638 pubmed publisher

Zhang X, Yao J, Li X, Niu N, Liu Y, Hajek R, et al. Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer. Sci Adv. 2023;9:eadf7195 pubmed publisher

Hertz E, Vega I, Kruse T, Wang Y, Hendriks I, Bizard A, et al. The SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure. Nat Struct Mol Biol. 2023;: pubmed publisher

Spruit C, Sweet I, Maliepaard J, Bestebroer T, Lexmond P, Qiu B, et al. Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection. Glycobiology. 2023;33:784-800 pubmed publisher

Wei H, Wang H, Wang G, Qu L, Jiang L, Dai S, et al. Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun. 2023;14:4300 pubmed publisher

Morgens D, Gulyas L, Souza A, Glaunsinger B. Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi's sarcoma-associated herpesvirus. bioRxiv. 2023;: pubmed publisher

Tamargo G xf3 mez I, Mart xed nez Garc xed a G, Su xe1 rez M, Mayoral P, Bretones G, Astudillo A, et al. Analysis of ATG4C function in vivo. Autophagy. 2023;:1-22 pubmed publisher

Cuevas Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, et al. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Sci Adv. 2023;9:eadf4766 pubmed publisher

Hu G, Huang N, Zhang J, Zhang D, Wang S, Zhang Y, et al. LKB1 loss promotes colorectal cancer cell metastasis through regulating TNIK expression and actin cytoskeleton remodeling. Mol Carcinog. 2023;: pubmed publisher

Yeh D, Liu C, Hernández J, Tahara S, Tsukamoto H, Machida K. Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. iScience. 2023;26:107035 pubmed publisher

Costa I, Effer B, Costa Silva T, Chen C, Ciccone M, Pessoa A, et al. Cathepsin B Is Not an Intrinsic Factor Related to Asparaginase Resistance of the Acute Lymphoblastic Leukemia REH Cell Line. Int J Mol Sci. 2023;24: pubmed publisher

Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, et al. Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion. Nat Commun. 2023;14:4084 pubmed publisher

Ju X, Wang Z, Wang P, Ren W, Yu Y, Yu Y, et al. SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense. MBio. 2023;:e0137323 pubmed publisher

Meyer L, Koschade S, Vischedyk J, Thoelken M, Gubas A, Wegner M, et al. Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia. Autophagy. 2023;:1-15 pubmed publisher

Yang J, Petty C, Dixon McDougall T, Lopez M, Tyshkovskiy A, Maybury Lewis S, et al. Chemically induced reprogramming to reverse cellular aging. Aging (Albany NY). 2023;15:5966-5989 pubmed publisher

Conway J, Din xe7 D, Follain G, Paavolainen O, Kaivola J, Bostr xf6 m P, et al. IGFBP2 secretion by mammary adipocytes limits breast cancer invasion. Sci Adv. 2023;9:eadg1840 pubmed publisher

Geng F, Zhong Y, Su H, Lefai E, Magaki S, Cloughesy T, et al. SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells. Cell Rep. 2023;42:112790 pubmed publisher

Alborzinia H, Chen Z, Yildiz U, Freitas F, Vogel F, Varga J, et al. LRP8-mediated selenocysteine uptake is a targetable vulnerability in MYCN-amplified neuroblastoma. EMBO Mol Med. 2023;:e18014 pubmed publisher

Zhao P, Wang Y, Yu X, Nan Y, Liu S, Li B, et al. Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis. Front Med. 2023;: pubmed publisher

Valakos D, Klagkou E, Kokkalis A, Polyzos A, Kyrilis F, Banos A, et al. Combinatorial targeting of a specific EMT/MET network by macroH2A variants safeguards mesenchymal identity. PLoS ONE. 2023;18:e0288005 pubmed publisher

Evans S, Shi D, Chavarha M, Plitt M, Taxidis J, Madruga B, et al. A positively tuned voltage indicator for extended electrical recordings in the brain. Nat Methods. 2023;20:1104-1113 pubmed publisher

Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval A, Ozturk H, et al. Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Nat Commun. 2023;14:4057 pubmed publisher

Beccano Kelly D, Cherubini M, Mousba Y, Cramb K, Giussani S, Caiazza M, et al. Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons. iScience. 2023;26:107044 pubmed publisher

Davidsen K, Marvin J, Aggarwal A, Brown T, Sullivan L. An engineered biosensor enables dynamic aspartate measurements in living cells. bioRxiv. 2023;: pubmed publisher

Pizzato H, Alonso Guallart P, Woods J, Johannesson B, Connelly J, Fehniger T, et al. Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers. bioRxiv. 2023;: pubmed publisher

Pallaseni A, Peets E, Girling G, Crepaldi L, Kuzmin I, Raudvere U, et al. The interplay of DNA repair context with target sequence predictably biasses Cas9-generated mutations. bioRxiv. 2023;: pubmed publisher

Praharaj P, Singh A, Patra S, Bhutia S. Co-targeting autophagy and NRF2 signaling triggers mitochondrial superoxide to sensitize oral cancer stem cells for cisplatin-induced apoptosis. Free Radic Biol Med. 2023;207:72-88 pubmed publisher

Romero Tejeda M, Fonoudi H, Weddle C, DeKeyser J, Lenny B, Fetterman K, et al. A novel transcription factor combination for direct reprogramming to a spontaneously contracting human cardiomyocyte-like state. J Mol Cell Cardiol. 2023;182:30-43 pubmed publisher

Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye V, Wrobel A, et al. TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry. Cell. 2023;: pubmed publisher

Wang R, Wang D, Bai X, Guo J, Xia S, Cheng Y, et al. Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma. Cell Death Discov. 2023;9:231 pubmed publisher

Coppola V, Marino I, Warnken U, Falchi M, Pasquini L, Biffoni M, et al. The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8). Autophagy. 2023;:1-19 pubmed publisher

Ma G, Zeng Y, Zhong W, Zhao X, Wang G, Bie F, et al. Comprehensive analysis of suppressor of cytokine signaling 2 protein in the malignant transformation of NSCLC. Exp Ther Med. 2023;26:370 pubmed publisher

Weidenauer K, Schmidt C, Rohde C, Pauli C, Blank M, Heid D, et al. The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia. Leukemia. 2023;: pubmed publisher

Rampias T, Klinakis A. Using Sister Chromatid Exchange Assay to Detect Homologous Recombination Deficiency in Epigenetically Deregulated Urothelial Carcinoma Cells. Methods Mol Biol. 2023;2684:133-144 pubmed publisher

Kaur N, de la Ballina L, Haukaas H, Torgersen M, Radulovic M, Munson M, et al. TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy. EMBO J. 2023;:e113105 pubmed publisher

Karimi T, Pan Z, Potaman V, Alt E. Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes. Cells. 2023;12: pubmed publisher

Kim H, Feng Y, Murad R, Poźniak J, Pelz C, Chen Y, et al. Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Sci Adv. 2023;9:eadf6621 pubmed publisher

Zhang Z, Zhang M, Zhou J, Wang D. Genome-wide CRISPR screening reveals ADCK3 as a key regulator in sensitizing endometrial carcinoma cells to MPA therapy. Br J Cancer. 2023;: pubmed publisher

Wessels H, Stirn A, M xe9 ndez Mancilla A, Kim E, Hart S, Knowles D, et al. Prediction of on-target and off-target activity of CRISPR-Cas13d guide RNAs using deep learning. Nat Biotechnol. 2023;: pubmed publisher

Griffin M, Thompson J, Xiao Y, Sweredoski M, Aksenfeld R, Jensen E, et al. Functional glycoproteomics by integrated network assembly and partitioning. bioRxiv. 2023;: pubmed publisher

Samelson A, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Goodness D, et al. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv. 2023;: pubmed publisher

Pedro M, Lund K, Kang S, Chen T, Stuelten C, Porat Shliom N, et al. A GPCR screening in human keratinocytes identifies that the metabolite receptor HCAR3 controls epithelial proliferation, migration, and cellular respiration. bioRxiv. 2023;: pubmed publisher

Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne T, Qian J, et al. Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes. Res Sq. 2023;: pubmed publisher

Yu Y, Cao W, Cheng F, Shi Z, Han L, Yi J, et al. FOXK2 amplification and overexpression promotes breast cancer development and chemoresistance. bioRxiv. 2023;: pubmed publisher

Liu Y, Choy M, Abraham S, Tenin G, Black G, Keavney B. Atrial Septal Defect (ASD) associated long non-coding RNA STX18-AS1 maintains time-course of in vitro cardiomyocyte differentiation. Genes Dis. 2023;10:1150-1153 pubmed publisher

Yoo H, La H, Park C, Yoo S, Lee H, Song H, et al. Common and distinct functions of mouse Dot1l in the regulation of endothelial transcriptome. Front Cell Dev Biol. 2023;11:1176115 pubmed publisher

Zhang Y, Ramirez Martinez A, Chen K, McAnally J, Cai C, Durbacz M, et al. Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy. J Clin Invest. 2023;133: pubmed publisher

Dimou E, Katsinelos T, Meisl G, Tuck B, Keeling S, Smith A, et al. Super-resolution imaging unveils the self-replication of tau aggregates upon seeding. Cell Rep. 2023;42:112725 pubmed publisher

Liu J, Min S, Kim D, Park J, Park E, Pei S, et al. Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemia. Leukemia. 2023;: pubmed publisher

Canale F, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, et al. Proteomics of immune cells from liver tumors reveals immunotherapy targets. Cell Genom. 2023;3:100331 pubmed publisher

Chen Z, Javed N, Moore M, Wu J, Sun G, Vinyard M, et al. Integrative dissection of gene regulatory elements at base resolution. Cell Genom. 2023;3:100318 pubmed publisher

Leoni C, Bataclan M, Ito Kureha T, Heissmeyer V, Monticelli S. The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells. Nat Commun. 2023;14:3862 pubmed publisher

Tang Y, Thiess L, Weiler S, T xf3 th M, Rose F, Merker S, et al. α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration. Cell Commun Signal. 2023;21:162 pubmed publisher

Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, et al. A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Protein Cell. 2023;: pubmed publisher

Chen L, Li Y, Chen Y. KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2. iScience. 2023;26:106914 pubmed publisher

Oh W, Kim A, Dhawan D, Kirkham P, Ostafe R, Franco J, et al. Development of an Anti-canine PD-L1 Antibody and Caninized PD-L1 Mouse Model as Translational Research Tools for the Study of Immunotherapy in Humans. Cancer Res Commun. 2023;3:860-873 pubmed publisher

Kaba M, Carreras Sureda A, Nunes Hasler P, Demaurex N. The lipid transfer proteins Nir2 and Nir3 sustain phosphoinositide signaling and actin dynamics during phagocytosis. J Cell Sci. 2023;136: pubmed publisher

Borkowska P, Morys J, Zielińska A, Kowalski J. Effects of the Co-Overexpression of the BCL and BDNF Genes on the Gamma-Aminobutyric Acid-Ergic Differentiation of Wharton's-Jelly-Derived Mesenchymal Stem Cells. Biomedicines. 2023;11: pubmed publisher

Shimizu Y, Bandaru S, Hara M, Young S, Sano T, Usami K, et al. An RNA-immunoprecipitation via CRISPR/dCas13 reveals an interaction between the SARS-CoV-2 5'UTR RNA and the process of human lipid metabolism. Sci Rep. 2023;13:10413 pubmed publisher

Liu Y, Potts J, Bloch D, Nian K, McCormick C, Fanari O, et al. Paired Capture and FISH Detection of Individual Virions Enable Cell-Free Determination of Infectious Titers. ACS Sens. 2023;8:2563-2571 pubmed publisher

Perelli L, Carbone F, Zhang L, Huang J, Le C, Khan H, et al. Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer. Nat Cancer. 2023;4:984-1000 pubmed publisher

Deol S, Donahue P, Mitrut R, Hammitt Kess I, Ahn J, Zhang B, et al. Comparative Evaluation of Synthetic Cytokines for Enhancing Production and Performance of NK92 Cell-Based Therapies. GEN Biotechnol. 2023;2:228-246 pubmed publisher

Rudd J, Maity S, Grunkemeyer J, Snyder J, Lovas S, Hansen L. Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4. J Biol Chem. 2023;299:104945 pubmed publisher

Grannemann C, Pabst A, Honert A, Schieren J, Martin C, Hank S, et al. Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release. Biomater Adv. 2023;152:213516 pubmed publisher

Cruz M, Gonzalez Y, V xe9 lez Toro J, Karimzadeh M, Rubbo A, Morris L, et al. Micronutrient optimization for tissue engineered articular cartilage production of type II collagen. Front Bioeng Biotechnol. 2023;11:1179332 pubmed publisher

Cheng H, Yuan J, Pei C, Ouyang M, Bu H, Chen Y, et al. The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1. Cell Biosci. 2023;13:114 pubmed publisher

Wang K, Pan Y, Wang D, Yuan Y, Li M, Chen Y, et al. Altered hACE2 binding affinity and S1/S2 cleavage efficiency of SARS-CoV-2 spike protein mutants affect viral cell entry. Virol Sin. 2023;: pubmed publisher

Song Z, Zhang G, Huang S, Liu Y, Li G, Zhou X, et al. PE-STOP: A versatile tool for installing nonsense substitutions amenable for precise reversion. J Biol Chem. 2023;299:104942 pubmed publisher

Lin L, Wang X, Chen Z, Deng T, Yan Y, Dong W, et al. TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1. PLoS Pathog. 2023;19:e1011472 pubmed publisher

Avula K, Singh B, Samantaray S, Syed G. The Early Secretory Pathway Is Crucial for Multiple Aspects of the Hepatitis C Virus Life Cycle. J Virol. 2023;97:e0018023 pubmed publisher

Benedetti E, Liu E, Tang C, Kuo F, Buyukozkan M, Park T, et al. A multimodal atlas of tumour metabolism reveals the architecture of gene-metabolite covariation. Nat Metab. 2023;5:1029-1044 pubmed publisher

Whitt A, Neely A, Sarkar O, Meng S, Arumugam S, Yaddanapudi K, et al. Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis. Sci Rep. 2023;13:9929 pubmed publisher

Gibson S, Madzharova E, Tan A, Allen M, Keller U, Jones J, et al. ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation. Matrix Biol. 2023;: pubmed publisher

H xe4 nsch L, Peipp M, Mastall M, Villars D, Myburgh R, Silginer M, et al. Chimeric antigen receptor (CAR) T cell-based targeting of CD317 as a novel immunotherapeutic strategy against glioblastoma. Neuro Oncol. 2023;: pubmed publisher

Martin J, Terry S, Gale J, Dawson S. The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition. J Cell Sci. 2023;136: pubmed publisher

Rafnsdottir S, Jang K, Halldorsdottir S, Tomasdottir A, Vinod M, M xf6 ller K, et al. SMYD5 is a novel epigenetic gatekeeper of the mild hypothermia response. bioRxiv. 2023;: pubmed publisher

Nelson A, Cicardi M, Markandaiah S, Han J, Philp N, Welebob E, et al. Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes. bioRxiv. 2023;: pubmed publisher

Gurler G, Belder N, Beker M, Sever Bahcekapili M, Uruk G, Kilic E, et al. Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity. Fluids Barriers CNS. 2023;20:47 pubmed publisher

Li C, Wilborn J, Pittman S, Daw J, Alonso P xe9 rez J, D xed az Manera J, et al. Comprehensive functional characterization of SGCB coding variants predicts pathogenicity in limb-girdle muscular dystrophy type R4/2E. J Clin Invest. 2023;133: pubmed publisher

Campbell A, Dyle M, Albanese R, Matheny T, Sudheendran K, Cort xe1 zar M, et al. Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression. Cell Rep. 2023;42:112642 pubmed publisher

Issa H, Bhayadia R, Winkler R, Swart L, Heckl D, Klusmann J. Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias. Leukemia. 2023;37:1583-1587 pubmed publisher

Bhosle V, Tan J, Li T, Hua R, Kwon H, Li Z, et al. SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing. Life Sci Alliance. 2023;6: pubmed publisher

Zheng W, Zhu T, Tang L, Li Z, Jiang G, Huang X. Inhalable CAR-T cell-derived exosomes as paclitaxel carriers for treating lung cancer. J Transl Med. 2023;21:383 pubmed publisher

Lu Y, Ma W, Ren G, Liu X, Li Y, Wang T, et al. VPS37C facilitates erythroid differentiation by promoting EKLF stability. Biochem Biophys Res Commun. 2023;671:229-235 pubmed publisher

Tian C, Zhou J, Li X, Gao Y, Wen Q, Kang X, et al. Impaired histone inheritance promotes tumor progression. Nat Commun. 2023;14:3429 pubmed publisher

English J, McSweeney D, Ribbe F, Howell E, Pak C. Generation and Co-culture of Cortical Glutamatergic and GABAergic-Induced Neuronal Cells. Methods Mol Biol. 2023;2683:21-37 pubmed publisher

Artico L, Ruas J, Teixeira J xfa nior J, Migita N, Seguchi G, Shi X, et al. IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis. Int J Mol Sci. 2023;24: pubmed publisher

Lee H, Ha S, Choi S, Do S, Yoon S, Kim Y, et al. Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells. Int J Mol Sci. 2023;24: pubmed publisher

Kim S, Ong Q, Liao Y, Ding Z, Tan A, Lim L, et al. Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling. Int J Mol Sci. 2023;24: pubmed publisher

Funkhouser Jones L, Xu R, Wilke G, Fu Y, Shriefer L, Makimaa H, et al. Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth. bioRxiv. 2023;: pubmed publisher

Garc xed a Mart xed nez K, Chen J, Jones J, Woo A, Aucapina A, Brito I, et al. Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response. bioRxiv. 2023;: pubmed publisher

Gordon E, Wright C, James M, Cooper S. Transcriptomic and functional analysis of ANGPTL4 overexpression in pancreatic cancer nominates targets that reverse chemoresistance. BMC Cancer. 2023;23:524 pubmed publisher

Bharathan N, Giang W, Hoffman C, Aaron J, Khuon S, Chew T, et al. Architecture and dynamics of a desmosome-endoplasmic reticulum complex. Nat Cell Biol. 2023;25:823-835 pubmed publisher

Wu X, Azizan E, Goodchild E, Garg S, Hagiyama M, Cabrera C, et al. Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. Nat Genet. 2023;55:1009-1021 pubmed publisher

Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Fay E, et al. Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. PLoS Biol. 2023;21:e3002144 pubmed publisher

Yan R, Moresco P, Gegenhuber B, Fearon D. T cell-Mediated Development of Stromal Fibroblasts with an Immune-Enhancing Chemokine Profile. Cancer Immunol Res. 2023;:OF1-OF11 pubmed publisher

Folcher A, Gordienko D, Iamshanova O, Bokhobza A, Shapovalov G, Kannancheri Puthooru D, et al. NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness. EMBO J. 2023;42:e112198 pubmed publisher

Ju X, Yu Y, Ren W, Dong L, Meng X, Deng H, et al. The PRMT5/WDR77 complex restricts hepatitis E virus replication. PLoS Pathog. 2023;19:e1011434 pubmed publisher

Wang Y, Yu Y, Yang W, Wu L, Yang Y, Lu Q, et al. SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence. Stem Cells Int. 2023;2023:7367854 pubmed publisher

Cui W, Huang Z, Jin S, Johnson J, Lau K, Hostetter G, et al. Deficiency of the Polycomb protein RYBP and TET methylcytosine oxidases promotes extensive CpG island hypermethylation and malignant transformation. Cancer Res. 2023;: pubmed publisher

Liu W, Zeng Y, Huang L, Zhang X, Bi L, Fan W, et al. RHOJ as a novel mechanosensitive modulator of endothelial inflammation. Biochem Biophys Res Commun. 2023;670:36-46 pubmed publisher

Kuiper J, Krause J, Potgeter L, Adrian J, Hauck C. A genome-wide genetic screen identifies CYRI-B as a negative regulator of CEACAM3-mediated phagocytosis. J Cell Sci. 2023;136: pubmed publisher

Strating E, Verhagen M, Wensink E, D xfc nnebach E, Wijler L, Aranguren I, et al. Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer. Front Immunol. 2023;14:1053920 pubmed publisher

Liu S, Sun D, Butler R, Rawlins E. RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells. Development. 2023;150: pubmed publisher

Renauer P, Park J, Bai M, Acosta A, Lee W, Lin G, et al. Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function. Cancer Immunol Res. 2023;: pubmed publisher

Slabber C, Bachofner M, Speicher T, Kuklin A, Fearon A, Padrissa Alt xe9 s S, et al. The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration. Sci Signal. 2023;16:eade8029 pubmed publisher

Kumar A, He S, Mali P. Systematic discovery of transcription factors that improve hPSC-derived cardiomyocyte maturation via temporal analysis of bioengineered cardiac tissues. APL Bioeng. 2023;7:026109 pubmed publisher

S xe3 o Jos xe9 C, Garcia Pelaez J, Ferreira M, Arrieta O, Andr xe9 A, Martins N, et al. Combined loss of CDH1 and downstream regulatory sequences drive early-onset diffuse gastric cancer and increase penetrance of hereditary diffuse gastric cancer. Gastric Cancer. 2023;26:653-666 pubmed publisher

Petersen J, Englmaier L, Artemov A, Poverennaya I, Mahmoud R, Bouderlique T, et al. A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Nat Commun. 2023;14:3092 pubmed publisher

Levis H, Weston J, Austin B, Larsen B, Ginley Hidinger M, Gullbrand S, et al. Multiplex gene editing to promote cell survival using low-pH clustered regularly interspaced short palindromic repeats activation (CRISPRa) gene perturbation. Cytotherapy. 2023;: pubmed publisher

Kaipa J, Krasnoselska G, Owens R, van den Heuvel J. Screening of Membrane Protein Production by Comparison of Transient Expression in Insect and Mammalian Cells. Biomolecules. 2023;13: pubmed publisher

Wang Y, Zhang H, La Ferlita A, Sp N, Goryunova M, Sarchet P, et al. Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity. Oncogenesis. 2023;12:30 pubmed publisher

Shapiro D, Zacharias N, Tripathi D, Karki M, Bertocchio J, Soeung M, et al. Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy. Clin Transl Med. 2023;13:e1267 pubmed publisher

Joensuu M, Syed P, Saber S, Lanoue V, Wallis T, Rae J, et al. Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry. EMBO J. 2023;42:e112095 pubmed publisher

Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias G, et al. Tumour extracellular vesicles and particles induce liver metabolic dysfunction. Nature. 2023;618:374-382 pubmed publisher

Nieminuszczy J, Martin P, Broderick R, Krwawicz J, Kanellou A, Mocanu C, et al. Actin nucleators safeguard replication forks by limiting nascent strand degradation. Nucleic Acids Res. 2023;51:6337-6354 pubmed publisher

Waryah C, Cursons J, Foroutan M, Pflueger C, Wang E, Molania R, et al. Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer. Adv Sci (Weinh). 2023;:e2301802 pubmed publisher

Ibrahim L, Stanton C, Nutsch K, Nguyen T, Li Ma C, Ko Y, et al. Succinylation of a KEAP1 sensor lysine promotes NRF2 activation. bioRxiv. 2023;: pubmed publisher

Sun X, Eastman G, Shi Y, Saibaba S, Oliveira A, Lukens J, et al. Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers. bioRxiv. 2023;: pubmed publisher

Guerrero Santoro J, Morizane M, Oh S, Mishima T, Goff J, Bildirici I, et al. The lipase cofactor CGI58 controls placental lipolysis. JCI Insight. 2023;8: pubmed publisher

Farahani P, Yang X, Mesev E, Fomby K, Brumbaugh Reed E, Bashor C, et al. pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells. elife. 2023;12: pubmed publisher

Nanes B, Bhatt K, Azarova E, Rajendran D, Isogai T, Dean K, et al. Keratin isoform shifts modulate motility signals during wound healing. bioRxiv. 2023;: pubmed publisher

Kwon Y, Hui S. IL-6 is dispensable for causing cachexia in the colon carcinoma 26 model. bioRxiv. 2023;: pubmed publisher

Zhang J, Zhu A, Mei M, Qu J, Huang Y, Shi Y, et al. Repurposing CRISPR/Cas to Discover SARS-CoV-2 Detecting and Neutralizing Aptamers. Adv Sci (Weinh). 2023;:e2300656 pubmed publisher

Sturtzel C, Grissenberger S, Bozatzi P, Scheuringer E, Wenninger Weinzierl A, Zajec Z, et al. Refined high-content imaging-based phenotypic drug screening in zebrafish xenografts. NPJ Precis Oncol. 2023;7:44 pubmed publisher

Maeda Y, Isomura A, Masaki T, Kageyama R. Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21. Cell Rep. 2023;42:112520 pubmed publisher

Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen V, Januszyk K, Voorhees R. A selectivity filter in the ER membrane protein complex limits protein misinsertion at the ER. J Cell Biol. 2023;222: pubmed publisher

Zhang K, Wu N, Cen J, Li J, Wang Z, Xia Q, et al. Ex vivo factor VIII-modified proliferating human hepatocytes therapy for haemophilia A. Cell Prolif. 2023;56:e13467 pubmed publisher

Hu J, Gao J, Wang C, Liu W, Hu A, Xiao X, et al. FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression. J Inflamm Res. 2023;16:2007-2020 pubmed publisher

Jiménez Moreno N, Salomó Coll C, Murphy L, Wilkinson S. Signal-Retaining Autophagy Indicator as a Quantitative Imaging Method for ER-Phagy. Cells. 2023;12: pubmed publisher

Li X, Shi W, Wei G, Lv J, Wang D, Xing B, et al. Galectin-1 promotes angiogenesis and chondrogenesis during antler regeneration. Cell Mol Biol Lett. 2023;28:40 pubmed publisher

Sambri I, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo M, et al. RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun. 2023;14:2775 pubmed publisher

McAllan L, Baranasic D, Villica xf1 a S, Brown S, Zhang W, Lehne B, et al. Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes. Nat Commun. 2023;14:2784 pubmed publisher

Zheng Z, Ye J, Leng M, Gan C, Tang N, Li W, et al. Enhanced sensitivity of neutralizing antibody detection for different AAV serotypes using HeLa cells with overexpressed AAVR. Front Pharmacol. 2023;14:1188290 pubmed publisher

Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim J, et al. Epigenetic landscape reveals MECOM as an endothelial lineage regulator. Nat Commun. 2023;14:2390 pubmed publisher

Best M, Lim Y, Ferenc N, Kim N, Min L, Wang D, et al. Extracellular Tau Oligomers Damage the Axon Initial Segment. J Alzheimers Dis. 2023;93:1425-1441 pubmed publisher

Xu K, Liu Q, Huang W, Chu Y, Fan W, Liu J, et al. Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells. Int J Mol Sci. 2023;24: pubmed publisher

Prahl L, Porter C, Liu J, Viola J, Hughes A. Independent control over cell patterning and adhesion on hydrogel substrates for tissue interface mechanobiology. iScience. 2023;26:106657 pubmed publisher

Pilat J, Brown R, Chen Z, Berle N, Othon A, Washington M, et al. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions. J Clin Invest. 2023;133: pubmed publisher

Lin Y, Hu Q, Mazzagatti A, Valle Incl xe1 n J, Maurais E, Dahiya R, et al. Mitotic clustering of pulverized chromosomes from micronuclei. Nature. 2023;618:1041-1048 pubmed publisher

Lyu J, Li Z, Roberts J, Qi Y, Xiong J. The short-chain fatty acid acetate coordinates with CD30 to modulate T-cell survival. Mol Biol Cell. 2023;34:br11 pubmed publisher

Zhou J, Guruvayurappan K, Chen H, Chen A, McVicker G. Genome-wide analysis of CRISPR perturbations indicates that enhancers act multiplicatively and without epistatic-like interactions. bioRxiv. 2023;: pubmed publisher

Quintanilla M, Patel H, Wu H, Sochacki K, Akamatsu M, Rotty J, et al. Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly. bioRxiv. 2023;: pubmed publisher

Radoua A, Pernon B, Pernet N, Jean C, Elmallah M, Guerrache A, et al. ptARgenOM-A Flexible Vector For CRISPR/CAS9 Nonviral Delivery. Small Methods. 2023;7:e2300069 pubmed publisher

Allchin E, Rosch J, Stoneman A, Kim H, Lippmann E. Generalized Strategy for Engineering Mammalian Cell-Compatible RNA-Based Biosensors from Random Sequence Libraries. ACS Sens. 2023;8:2079-2086 pubmed publisher

Osipovich A, Dudek K, Trinh L, Kim L, Shrestha S, Cartailler J, et al. ZFP92, a KRAB domain zinc finger protein enriched in pancreatic islets, binds to B1/Alu SINE transposable elements and regulates retroelements and genes. PLoS Genet. 2023;19:e1010729 pubmed publisher

Taha Z, Crupi M, Alluqmani N, Fareez F, Ng K, Sobh J, et al. Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus. Front Immunol. 2023;14:1181014 pubmed publisher

Wei C, Du J, Shen Y, Wang Z, Lin Q, Chen J, et al. Anticancer effect of involucrasin A on colorectal cancer cells by modulating the Akt/MDM2/p53 pathway. Oncol Lett. 2023;25:218 pubmed publisher

Wang S, Davenport A, Iliopoulos M, Hughes Parry H, Watson K, Arcucci V, et al. HER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma. Neurooncol Adv. 2023;5:vdad024 pubmed publisher

Mahr R, Jena S, Nashif S, Nelson A, Rauckhorst A, Rome F, et al. Mitochondrial citrate metabolism and efflux regulate BeWo differentiation. Sci Rep. 2023;13:7387 pubmed publisher

Cetin R, Wegner M, Luwisch L, Saud S, Achmedov T, S xfc sser S, et al. Optimized metrics for orthogonal combinatorial CRISPR screens. Sci Rep. 2023;13:7405 pubmed publisher

Li X, Zhang C, Bowman H, Stambough J, Stronach B, Mears S, et al. Piezo1 opposes age-associated cortical bone loss. Aging Cell. 2023;22:e13846 pubmed publisher

Pandit M, Kil Y, Ahn J, Pokhrel R, Gu Y, Mishra S, et al. Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells. Nat Commun. 2023;14:2593 pubmed publisher

Awadia S, Sitto M, Ram S, Ji W, Liu Y, Damani R, et al. The adapter protein FADD provides an alternate pathway for entry into the cell cycle by regulating APC/C-Cdh1 E3 ubiquitin ligase activity. J Biol Chem. 2023;299:104786 pubmed publisher

Wilson B, Su Z, Kumar P, Dutta A. XRN2 suppresses aberrant entry of tRNA trailers into argonaute in humans and Arabidopsis. PLoS Genet. 2023;19:e1010755 pubmed publisher

Sharp C, Thompson B, Nash T, Diebold O, Pinto R, Thorley L, et al. CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy. PLoS Pathog. 2023;19:e1011357 pubmed publisher

Tan C, Gamage A, Yap W, Wei Tang L, Sun Y, Yang X, et al. Pteropine orthoreoviruses use cell surface heparan sulphate as an attachment receptor. Emerg Microbes Infect. 2023;12:2208683 pubmed publisher

Kuwazuru J, Suico M, Omachi K, Kojima H, Kamura M, Kaseda S, et al. CyclosporinA Derivative as Therapeutic Candidate for Alport Syndrome by Inducing Mutant Type IV Collagen Secretion. Kidney360. 2023;4:909-917 pubmed publisher

Morris J, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, et al. Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens. Science. 2023;380:eadh7699 pubmed publisher

Khan S, Raj D, Sahu S, Naseer A, Singh N, Kumari S, et al. CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis. JCI Insight. 2023;8: pubmed publisher

He W, Gea Mallorqu xed E, Colin York H, Fritzsche M, Gillespie G, Brackenridge S, et al. Intracellular trafficking of HLA-E and its regulation. J Exp Med. 2023;220: pubmed publisher

Liu J, Min S, Kim D, Park J, Park E, Koh Y, et al. Epigenetic priming improves salvage chemotherapy in diffuse large B-cell lymphoma via endogenous retrovirus-induced cGAS-STING activation. Clin Epigenetics. 2023;15:75 pubmed publisher

Lu Y, Cao Q, Yu Y, Sun Y, Jiang X, Li X. Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications. BMC Genomics. 2023;24:235 pubmed publisher

Park J, Gazzaniga F, Wu M, Luthens A, Gillis J, Zheng W, et al. Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023;617:377-385 pubmed publisher

Wang M, Wisniewski C, Xiong C, Chhoy P, Goel H, Kumar A, et al. Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer. Sci Transl Med. 2023;15:eade5855 pubmed publisher

Feng F, Bouma E, Hu G, Zhu Y, Yu Y, Smit J, et al. Colocalization of Chikungunya Virus with Its Receptor MXRA8 during Cell Attachment, Internalization, and Membrane Fusion. J Virol. 2023;97:e0155722 pubmed publisher

Spear J, White K. Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition. J Cell Sci. 2023;136: pubmed publisher

Yu C, Rao D, Wang T, Sheng J, Lv E, Zhang L, et al. Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR. J Cell Mol Med. 2023;27:1523-1538 pubmed publisher

Bagheri M, Mohamed G, Ashick M, Saleem M, Ognjenovic N, Lu H, et al. Pharmacological Induction of mesenchymal-epithelial transition chemosensitizes breast cancer cells and prevents metastatic progression. bioRxiv. 2023;: pubmed publisher

Bulos M, Grzelak E, Li Ma C, Chen E, Hull M, Johnson K, et al. "Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2". bioRxiv. 2023;: pubmed publisher

Wang Y, Seibert H, Ahn L, Schaffer A, Mu T. Pharmacological chaperones restore proteostasis of epilepsy-associated GABA A receptor variants. bioRxiv. 2023;: pubmed publisher

Wang Q, Jiang F, Zhao C, Song J, Hu M, Lv Y, et al. miR-21-5p prevents doxorubicin-induced cardiomyopathy by downregulating BTG2. Heliyon. 2023;9:e15451 pubmed publisher

Yang Y, Bhargava D, Chen X, Zhou T, Dursuk G, Jiang W, et al. KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress. Cell Death Dis. 2023;14:299 pubmed publisher

Bishop T, Subramanian C, Bilotta E, Garnar Wortzel L, Ramos A, Zhang Y, et al. Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition. Nat Chem Biol. 2023;: pubmed publisher

Li H, Lin C, Qi W, Sun Z, Xie Z, Jia W, et al. Senecavirus A-induced glycolysis facilitates virus replication by promoting lactate production that attenuates the interaction between MAVS and RIG-I. PLoS Pathog. 2023;19:e1011371 pubmed publisher

Gao R, Tang F, Christofori G. Protocol to screen for Sorafenib resistance regulators using pooled lentiviral shRNA library and a Sorafenib-resistant hepatocellular carcinoma cell model. STAR Protoc. 2023;4:102273 pubmed publisher

Sgro A, Cursons J, Waryah C, Woodward E, Foroutan M, Lyu R, et al. Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma. Clin Epigenetics. 2023;15:73 pubmed publisher

Yu G, Kim H, Park J, Kwak H, Cheong Y, Kim D, et al. Prediction of efficiencies for diverse prime editing systems in multiple cell types. Cell. 2023;186:2256-2272.e23 pubmed publisher

Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, et al. m6A epitranscriptomic regulation of tissue homeostasis during primate aging. Nat Aging. 2023;3:705-721 pubmed publisher

Xiong Y, Zhang X, Zhu J, Zhang Y, Pan Y, Wu Y, et al. Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression. Cell Death Differ. 2023;30:1648-1665 pubmed publisher

da Fonseca Ferreira A, Wei J, Zhang L, Macon C, Degnan B, Jayaweera D, et al. HIV Promotes Atherosclerosis via Circulating Extracellular Vesicle MicroRNAs. Int J Mol Sci. 2023;24: pubmed publisher

Elcocks H, Brazel A, McCarron K, Kaulich M, Husnjak K, Mortiboys H, et al. FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels. EMBO J. 2023;42:e112799 pubmed publisher

Mihali x10d F, Simonetti L, Giudice G, Sander M, Lindqvist R, Peters M, et al. Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs. Nat Commun. 2023;14:2409 pubmed publisher

Liu S, Hur Y, Cai X, Cong Q, Yang Y, Xu C, et al. A tissue injury sensing and repair pathway distinct from host pathogen defense. Cell. 2023;186:2127-2143.e22 pubmed publisher

Qin L, Fan W, Zheng F, Chen H, Qian P, Li X. Swine IFI6 confers antiviral effects against Japanese encephalitis virus in vitro and in vivo. J Gen Virol. 2023;104: pubmed publisher

Armendariz D, Goetsch S, Sundarrajan A, Sivakumar S, Wang Y, Xie S, et al. CHD-associated enhancers shape human cardiomyocyte lineage commitment. elife. 2023;12: pubmed publisher

Spens A, Sutliff N, Bennett S, Campbell A, Tapscott S. Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. elife. 2023;12: pubmed publisher

Iyengar P, Gandhi A, Granados J, Guo T, Gupta A, Yu J, et al. Tumor loss-of-function mutations in STK11/LKB1 induce cachexia. JCI Insight. 2023;8: pubmed publisher

Rogers B, Anderson A, Lauzon S, Davis M, Hauser R, Roberts S, et al. MAPT expression is mediated by long-range interactions with cis -regulatory elements. bioRxiv. 2023;: pubmed publisher

Yoon D, Choi Y, Lee K, Ko E, Kim E, Park K, et al. Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss. J Biomed Sci. 2023;30:26 pubmed publisher

Gupta A, Li Y, Chen S, Papas B, Martin N, Morgan M. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Commun Biol. 2023;6:438 pubmed publisher

Herrejon Chavez F, Luo H, Cifani P, Pine A, Chu K, Joshi S, et al. RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nat Commun. 2023;14:2290 pubmed publisher

Fan W, Jurado Arjona J, Alanis Lobato G, P xe9 ron S, Berger C, Andrade Navarro M, et al. The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. EMBO J. 2023;42:e110384 pubmed publisher

Mart xed nez Zamudio R, Stefa A, Nabuco Leva Ferreira Freitas J, Vasilopoulos T, Simpson M, Dor xe9 G, et al. Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars. Cell Genom. 2023;3:100293 pubmed publisher

Fu L, Wang X, Yang Y, Chen M, Kuerban A, Liu H, et al. Septin11 promotes hepatocellular carcinoma cell motility by activating RhoA to regulate cytoskeleton and cell adhesion. Cell Death Dis. 2023;14:280 pubmed publisher

Li M, Yang L, Chan A, Pokharel S, Liu Q, Mattson N, et al. Epigenetic Control of Translation Checkpoint and Tumor Progression via RUVBL1-EEF1A1 Axis. Adv Sci (Weinh). 2023;10:e2206584 pubmed publisher

McCollum C, Didychuk A, Liu D, Murray Nerger L, Cristea I, Glaunsinger B. The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection. PLoS Pathog. 2023;19:e1011163 pubmed publisher

Jo D, Kaczmarek S, Shin O, Wang L, Cowan J, McComb S, et al. Simultaneous engineering of natural killer cells for CAR transgenesis and CRISPR-Cas9 knockout using retroviral particles. Mol Ther Methods Clin Dev. 2023;29:173-184 pubmed publisher

Kiss L, Rhinesmith T, Lupták J, Dickson C, Weidenhausen J, Smyly S, et al. Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates. Nat Commun. 2023;14:2160 pubmed publisher

Basu A, Champagne R, Patel N, Nicholson E, Weiss R. TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth. J Biol Chem. 2023;299:104713 pubmed publisher

Chandra K, Swathi M, Keerthana B, Gopan S, Ghantasala J, Joshi M, et al. PHLPP1 regulates PINK1-parkin signalling and life span. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166718 pubmed publisher

Haluck Kangas A, Fink M, Bartom E, Peter M. CD95/Fas ligand mRNA is toxic to cells through more than one mechanism. Mol Biomed. 2023;4:11 pubmed publisher

Huber M, Casares Arias J, F xe4 ssler R, M xfc ller D, Strohmeyer N. In mitosis integrins reduce adhesion to extracellular matrix and strengthen adhesion to adjacent cells. Nat Commun. 2023;14:2143 pubmed publisher

Kurden Pekmezci A, Cakiroglu E, Eris S, Mazi F, Coskun Deniz O, Dalgic E, et al. MALT1 paracaspase is overexpressed in hepatocellular carcinoma and promotes cancer cell survival and growth. Life Sci. 2023;323:121690 pubmed publisher

Tomofuji K, Kondo J, Onuma K, Coppo R, Horie H, Oyama K, et al. Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors. Hepatol Commun. 2023;7: pubmed publisher

Wang L, Paudel B, McKnight R, Janes K. Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state. Nat Commun. 2023;14:2110 pubmed publisher

Kurhade C, Kang S, Biering S, Hwang S, Randall G. CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. MBio. 2023;14:e0017223 pubmed publisher

Astone M, Oberkersch R, Tosi G, Biscontin A, Santoro M. The circadian protein BMAL1 supports endothelial cell cycle during angiogenesis. Cardiovasc Res. 2023;: pubmed publisher

Galappaththi S, Katz B, Howze P, Hoover G, Grelet S. A CRISPR/Cas9-Based Assay for High-Throughput Studies of Cancer-Induced Innervation. Cancers (Basel). 2023;15: pubmed publisher

Luo Y, Liu S, Xue J, Yang Y, Zhao J, Sun Y, et al. High-throughput screening of spike variants uncovers the key residues that alter the affinity and antigenicity of SARS-CoV-2. Cell Discov. 2023;9:40 pubmed publisher

Truong M, Can xe9 Gasull P, De Vries S, Nijenhuis W, Wardenaar R, Kapitein L, et al. A kinesin-based approach for inducing chromosome-specific mis-segregation in human cells. EMBO J. 2023;42:e111559 pubmed publisher

Panizza E, Regalado B, Wang F, Nakano I, Vacanti N, Cerione R, et al. Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma. Life Sci Alliance. 2023;6: pubmed publisher

Panzi C, Surana S, De La Rocque S, Moretto E, Lazo O, Schiavo G. Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons. Toxicon. 2023;228:107110 pubmed publisher

Zhang Z, Yu T, Li H, Du L, Jin Z, Peng X, et al. Long Noncoding RNA AROD Inhibits Host Antiviral Innate Immunity via the miR-324-5p-CUEDC2 Axis. Microbiol Spectr. 2023;11:e0420622 pubmed publisher

Zhao X, Wu X, Wang H, Lai S, Wang J. Targeted therapy for cisplatin-resistant lung cancer via aptamer-guided nano-zinc carriers containing USP14 siRNA. MedComm (2020). 2023;4:e237 pubmed publisher

Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, et al. Asparagine starvation suppresses histone demethylation through iron depletion. iScience. 2023;26:106425 pubmed publisher

Kim T, Koo S, Riessland M, Cho H, Chaudhry F, Kolisnyk B, et al. TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron. bioRxiv. 2023;: pubmed publisher

Szczygie x142 A, W x119 gierek Ciura K, Wr xf3 blewska A, Mierzejewska J, Rossowska J, Szermer Olearnik B, et al. Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma. Front Immunol. 2023;14:1155377 pubmed publisher

Kwon P, Xu S, Oh H, Kwon S, Rodrigues A, Feroz M, et al. Suramin binds and inhibits infection of SARS-CoV-2 through both spike protein-heparan sulfate and ACE2 receptor interactions. Commun Biol. 2023;6:387 pubmed publisher

Usluer S, Hallast P, Crepaldi L, Zhou Y, Urgo K, Dincer C, et al. Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells. Stem Cell Reports. 2023;18:1061-1074 pubmed publisher

Yamaguchi S, Xie Q, Ito F, Terao K, Kato Y, Kuroiwa M, et al. Carbon nanotube recognition by human Siglec-14 provokes inflammation. Nat Nanotechnol. 2023;18:628-636 pubmed publisher

Xie H, Yang E, Wang C, Peng C, Ji L. Targeting HDAC11 activity by FT895 restricts EV71 replication. Virus Res. 2023;330:199108 pubmed publisher

Hsu W, Ma Y, Chen Y, Liu Y, Cheng K, Lee E. Identification of Ndfip1 as a novel negative regulator for spatial memory formation associated with increased ubiquitination of Beclin 1 and PTEN. PLoS ONE. 2023;18:e0283908 pubmed publisher

Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, et al. A stress-induced cilium-to-PML-NB route drives senescence initiation. Nat Commun. 2023;14:1840 pubmed publisher

Descovich C, Lough K, Jena A, Wu J, Yom J, Spitzer D, et al. AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis. elife. 2023;12: pubmed publisher

Gao J, Hu J, Yu F, Wang C, Sheng D, Liu W, et al. Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling. BMC Cancer. 2023;23:306 pubmed publisher

Zheng Z, Wu M, Li H, Xu W, Yang M, Pan K, et al. Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis. BMC Med. 2023;21:132 pubmed publisher

Frost J, Amante S, Okae H, Jones E, Ashley B, Lewis R, et al. Regulation of human trophoblast gene expression by endogenous retroviruses. Nat Struct Mol Biol. 2023;30:527-538 pubmed publisher

Ren W, Zhang Y, Rao J, Wang Z, Lan J, Liu K, et al. Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) Variant. MBio. 2023;14:e0041623 pubmed publisher

Mathiowetz A, Roberts M, Morgens D, Olzmann J, Li Z. Protocol for performing pooled CRISPR-Cas9 loss-of-function screens. STAR Protoc. 2023;4:102201 pubmed publisher

Barua D, Sultana A, Islam M, Cox F, Gupta A, Gupta S. RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity. BMC Cancer. 2023;23:288 pubmed publisher

Nadler M, Chang W, Ozkaynak E, Huo Y, Nong Y, Boillot M, et al. Hominoid SVA-lncRNA AK057321 targets human-specific SVA retrotransposons in SCN8A and CDK5RAP2 to initiate neuronal maturation. Commun Biol. 2023;6:347 pubmed publisher

Moyer A, Fernandez F, Li Y, Klinedinst D, Florea L, Kazuki Y, et al. Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome. Dis Model Mech. 2023;16: pubmed publisher

L xf3 pez Farf xe1 n D, Irigoyen N, G xf3 mez D xed az E. Exploring SARS-CoV-2 and Plasmodium falciparum coinfection in human erythrocytes. Front Immunol. 2023;14:1120298 pubmed publisher

Baniulyte G, Durham S, Merchant L, Sammons M. Shared gene targets of the ATF4 and p53 transcriptional networks. bioRxiv. 2023;: pubmed publisher

Virga D, Hamilton S, Osei B, Morgan A, Zamponi E, Park N, et al. Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons. bioRxiv. 2023;: pubmed publisher

Conti B, Ruiz P, Broton C, Blobel N, Kottemann M, Sridhar S, et al. RTF2 controls replication repriming and ribonucleotide excision at the replisome. bioRxiv. 2023;: pubmed publisher

Zhang W, Lu C, Nakamoto M, Tsai C, Roy A, Lee C, et al. Curved adhesions mediate cell attachment to soft matrix fibres in 3D. bioRxiv. 2023;: pubmed publisher

Zhang L, He W, Fu R, Xu H. Guide-specific loss of efficiency and off-target reduction with Cas9 variants. bioRxiv. 2023;: pubmed publisher

Bhat A, Mohapatra B, Luan H, Mushtaq I, Chakraborty S, Dutta S, et al. Role of GD2 and its biosynthetic enzyme GD3 synthase in prostate cancer tumorigenesis. bioRxiv. 2023;: pubmed publisher

Takaku M, Saotome M, Poduval D, Grimm S, Nagornyuk A, Gunarathna S, et al. Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4. Res Sq. 2023;: pubmed publisher

Zhao Y, Teng H, Deng Y, Sheldon M, Martínez C, Zhang J, et al. Long noncoding RNA Malat1 inhibits Tead3-Nfatc1-mediated osteoclastogenesis to suppress osteoporosis and bone metastasis. Res Sq. 2023;: pubmed publisher

Tuano N, Beesley J, Manning M, Shi W, Perlaza Jiménez L, Malaver Ortega L, et al. CRISPR screens identify gene targets at breast cancer risk loci. Genome Biol. 2023;24:59 pubmed publisher

De Rosa P, Severi F, Zadran S, Russo M, Aloisi S, Rigamonti A, et al. MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells. Int J Mol Sci. 2023;24: pubmed publisher

Kroll M, Schloer S, Candan P, Korthals N, Wenzel C, Ihle H, et al. Importance of ACE2 for SARS-CoV-2 Infection of Kidney Cells. Biomolecules. 2023;13: pubmed publisher

Thomas S, Dienger Stambaugh K, Jordan M, Wang Y, Hammonds J, Spearman P, et al. Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species. Bioengineering (Basel). 2023;10: pubmed publisher

Yashar W, Curtiss B, Coleman D, VanCampen J, Kong G, Macaraeg J, et al. Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia. Mol Cancer Res. 2023;21:631-647 pubmed publisher

Cao M, Zou X, Li C, Lin Z, Wang N, Zou Z, et al. An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis. Nat Commun. 2023;14:1687 pubmed publisher

Kim J, Hwang Y, Kim S, Chang Y, Kim Y, Kwon Y, et al. Transcriptional activation of endogenous Oct4 via the CRISPR/dCas9 activator ameliorates Hutchinson-Gilford progeria syndrome in mice. Aging Cell. 2023;22:e13825 pubmed publisher

Wang Y, Kelso A, Karamafrooz A, Chen Y, Chen W, Cheng C, et al. Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination. Cell Rep. 2023;42:112296 pubmed publisher

Hu Z, Liu Y, Tang J, Luo R, Qin J, Mo Z, et al. LncRNA HHIP-AS1 suppresses lung squamous cell carcinoma by stabilizing HHIP mRNA. Life Sci. 2023;321:121578 pubmed publisher

Hardaway A, Goodarzi M, Berk M, Li J, Chung Y, Sharifi N. Response to "Letter to the Editor From Penning and Deltefsen "5-hydroxyeicosatetraenoic Acid Controls Androgen Reduction in Diverse Types of Human Epithelial Cells". Endocrinology. 2023;164: pubmed publisher

Jbara A, Lin K, Stossel C, Siegfried Z, Shqerat H, Amar Schwartz A, et al. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature. 2023;617:147-153 pubmed publisher

Kliesmete Z, Wange L, Vieth B, Esgleas M, Radmer J, H xfc lsmann M, et al. Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals. elife. 2023;12: pubmed publisher

Martin E, Rodriguez Y Baena A, Reggiardo R, Worthington A, Mattingly C, Poscablo D, et al. Dynamics of Chromatin Accessibility During Hematopoietic Stem Cell Differentiation Into Progressively Lineage-Committed Progeny. Stem Cells. 2023;41:520-539 pubmed publisher

Agarwal V, Inoue F, Schubach M, Martin B, Dash P, Zhang Z, et al. Massively parallel characterization of transcriptional regulatory elements in three diverse human cell types. bioRxiv. 2023;: pubmed publisher

Tomas Bort E, Joseph M, Wang Q, Carter E, Roth N, Gibson J, et al. Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. elife. 2023;12: pubmed publisher

Zhao P, Sun L, Zhao C. TCF1/LEF1 triggers Wnt-dependent chemokine/cytokine-induced inflammation and cadherin pathways to drive T-ALL cell migration. Biochem Biophys Rep. 2023;34:101457 pubmed publisher

Pan C, Li R, Shui L, Xiao Z, Wang Y, Zhu J, et al. A new method to synthesize multiple gRNA libraries and functional mapping of mammalian H3K4me3 regions. Nucleic Acids Res. 2023;51:e50 pubmed publisher

Rojo Romanos T, Karpinski J, Millen S, Beschorner N, Simon F, Paszkowski Rogacz M, et al. Precise excision of HTLV-1 provirus with a designer-recombinase. Mol Ther. 2023;31:2266-2285 pubmed publisher

Fan Z, Ardicoglu R, Batavia A, Rust R, von Ziegler L, Waag R, et al. The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions. Angiogenesis. 2023;26:385-407 pubmed publisher

Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, et al. Single-cell transcriptomic atlas of mouse cochlear aging. Protein Cell. 2023;14:180-201 pubmed publisher

Tian R, Yang J, Wang X, Liu S, Dong R, Wang Z, et al. Honokiol acts as an AMPK complex agonist therapeutic in non-alcoholic fatty liver disease and metabolic syndrome. Chin Med. 2023;18:30 pubmed publisher

Li K, Figarella K, Su X, Kovalchuk Y, Gorzolka J, Neher J, et al. Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb. Cell Mol Life Sci. 2023;80:98 pubmed publisher

Eichner L, Curtis S, Brun S, McGuire C, Gushterova I, Baumgart J, et al. HDAC3 is critical in tumor development and therapeutic resistance in Kras-mutant non-small cell lung cancer. Sci Adv. 2023;9:eadd3243 pubmed publisher

Trevarton A, Mears E, Moody J, Lopdell T, Chometon T, Taylor J, et al. Development of SpCas9-expressing bovine mammary epithelial cell lines. In Vitro Cell Dev Biol Anim. 2023;59:163-165 pubmed publisher

Gilhaus K, Cepok C, Kamm D, Surmann B, Nedvetsky P, Emich J, et al. Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins. J Am Soc Nephrol. 2023;34:1039-1055 pubmed publisher

Zhang Q, Li J, Chen Z, Jiang K, Yang K, Huang F, et al. VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma. Cell Oncol (Dordr). 2023;46:1001-1014 pubmed publisher

He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, et al. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. Protein Cell. 2023;14:202-216 pubmed publisher

Tomoda E, Nagao A, Shirai Y, Asano K, Suzuki T, Battersby B, et al. Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases. Nucleic Acids Res. 2023;: pubmed publisher

Patel P, Algouneh A, Krishnan R, Reynolds J, Nixon K, Hao J, et al. Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers. Nucleic Acids Res. 2023;51:4341-4362 pubmed publisher

Wang N, Zhang Y, Jiang F, Zhu D, Di C, Hu S, et al. Enhancer variants on chromosome 2p14 regulating SPRED2 and ACTR2 act as a signal amplifier to protect against rheumatoid arthritis. Am J Hum Genet. 2023;110:625-637 pubmed publisher

Tao A, Lacroix A, Shoyer T, Venkatraman V, Xu K, Feiger B, et al. Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions. Dev Cell. 2023;58:522-534.e7 pubmed publisher

McCann J, FLEENOR D, Chen J, Lai C, Bass T, Kastan M. Participation of ATM, SMG1, and DDX5 in a DNA Damage-Induced Alternative Splicing Pathway. Radiat Res. 2023;199:406-421 pubmed publisher

Zhang X, Du Q, Chen G, Jiang Y, Huang K, Li L, et al. Guanylate-binding protein 1 inhibits nuclear delivery of pseudorabies virus by disrupting structure of actin filaments. Vet Res. 2023;54:21 pubmed publisher

Tang X, Xue D, Zhang T, Nilsson Payant B, Carrau L, Duan X, et al. A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nat Cell Biol. 2023;25:381-389 pubmed publisher

Uno S, Harkiss A, Chowdhury R, Caldwell S, Prime T, James A, et al. Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs. Chembiochem. 2023;24:e202200774 pubmed publisher

Xu H, Li Z, Kuo C, G xf6 tz K, Look T, de Toledo M, et al. A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation. elife. 2023;12: pubmed publisher

Deng C, Zhang G, Liu Q, Xu J, Liu Z, Yang J, et al. ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis. Cancer Res. 2023;83:1851-1865 pubmed publisher

Leclerc K, Remark L, Ramsukh M, Josephson A, Palma L, Parente P, et al. Hox genes are crucial regulators of periosteal stem cell identity. Development. 2023;150: pubmed publisher

Reddy A, Herschl M, Kolli S, Lu A, Geng X, Kumar A, et al. Pretraining strategies for effective promoter-driven gene expression prediction. bioRxiv. 2023;: pubmed publisher

Nair H, Jurkiewicz A, Graczyk D. Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFα. Cancers (Basel). 2023;15: pubmed publisher

Szwarc M, Guarnieri A, Joshi M, Duc H, Laird M, Pandey A, et al. FAM193A is a positive regulator of p53 activity. Cell Rep. 2023;42:112230 pubmed publisher

Sobajima T, Kowalczyk K, Skylakakis S, Hayward D, Fulcher L, Neary C, et al. PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. J Cell Biol. 2023;222: pubmed publisher

Qin Z, Zhang W, Liu S, Wang Y, Peng X, Jia L. PVT1 inhibition stimulates anti-tumor immunity, prevents metastasis, and depletes cancer stem cells in squamous cell carcinoma. Cell Death Dis. 2023;14:187 pubmed publisher

Wang T, Chen Y, Nyström N, Liu S, Fu Y, Martinez F, et al. Visualizing cell-cell communication using synthetic notch activated MRI. Proc Natl Acad Sci U S A. 2023;120:e2216901120 pubmed publisher

Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude K, Wang N, et al. Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc Natl Acad Sci U S A. 2023;120:e2218238120 pubmed publisher

Zecchini V, Paupe V, Herranz Montoya I, Janssen J, Wortel I, Morris J, et al. Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature. 2023;615:499-506 pubmed publisher

Hart M, Quon E, Vigil A, Engstrom I, Newsom O, Davidsen K, et al. Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells. elife. 2023;12: pubmed publisher

Ghantous L, Volman Y, Hefez R, Wald O, STERN E, Friehmann T, et al. The DNA damage response pathway regulates the expression of the immune checkpoint CD47. Commun Biol. 2023;6:245 pubmed publisher

Huang S, Li J, Wu S, Zheng Z, Wang C, Li H, et al. C4orf19 inhibits colorectal cancer cell proliferation by competitively binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6 axis. Oncogene. 2023;42:1333-1346 pubmed publisher

Liao L, He Y, Li S, Yu X, Liu Z, Liang Y, et al. Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner. Cell Res. 2023;33:355-371 pubmed publisher

Sandilands E, Freckmann E, Cumming E, Rom xe1 n Fern xe1 ndez A, McGarry L, Anand J, et al. The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. J Cell Biol. 2023;222: pubmed publisher

Park J, Cui G, Lee H, Jeong H, Kwak J, Lee J, et al. CRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularization. Sci Rep. 2023;13:3715 pubmed publisher

Wang Z, Liang Q, Qian X, Hu B, Zheng Z, Wang J, et al. An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Nat Commun. 2023;14:1208 pubmed publisher

Hastings J, Latham S, Kamili A, Wheatley M, Han J, Wong Erasmus M, et al. Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma. Sci Adv. 2023;9:eabp8314 pubmed publisher

Kasamkattil J, Gryadunova A, Schmid R, Gay Dujak M, Dasen B, Hilpert M, et al. Human 3D nucleus pulposus microtissue model to evaluate the potential of pre-conditioned nasal chondrocytes for the repair of degenerated intervertebral disc. Front Bioeng Biotechnol. 2023;11:1119009 pubmed publisher

Yu M, Hu X, Pan Z, Du C, Jiang J, Zheng W, et al. Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Nucleic Acids Res. 2023;51:4745-4759 pubmed publisher

Tylawsky D, Kiguchi H, Vaynshteyn J, Gerwin J, Shah J, Islam T, et al. P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis. Nat Mater. 2023;22:391-399 pubmed publisher

Xie H, Kang Y, Liu J, Huang M, Dai Z, Shi J, et al. Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafish. PLoS Biol. 2023;21:e3002008 pubmed publisher

Yamamoto Y, Shimada S, Akiyama Y, Tsukihara S, Sugimoto R, Kabashima A, et al. RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. J Gastroenterol. 2023;58:540-553 pubmed publisher

Norris M, Mendell J. Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein. Genes Dev. 2023;37:191-203 pubmed publisher

Ayyar B, Ettayebi K, Salmen W, Karandikar U, Neill F, Tenge V, et al. CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection. Nat Commun. 2023;14:1148 pubmed publisher

Iwasaki Y, Aksu C, Reyes M, Ay B, He Q, Bastepe M. The long-range interaction between two GNAS imprinting control regions delineates pseudohypoparathyroidism type 1B pathogenesis. J Clin Invest. 2023;133: pubmed publisher

Simeoni F, Loukas I, Wilson T, Scaffidi P. CRISPR-based large-scale modeling of loss-of-function mutations to investigate mechanisms of stress resistance in cancer. STAR Protoc. 2023;4:102097 pubmed publisher

An H, Tian X, Huang Y, Zhang J. Identification of the mouse Kupffer cell receptors recognizing pneumococcal capsules by affinity screening. STAR Protoc. 2023;4:102065 pubmed publisher

Ran X, Lu Q, Li Y, Pu X, Guo Y, Yuan M, et al. Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway. Heliyon. 2023;9:e13691 pubmed publisher

Fricke T, Schlagowski S, Liu S, Yang X, Fiebig U, Kaul A, et al. Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins. Viruses. 2023;15: pubmed publisher

Sui X, Chen C, Zhou X, Wen X, Shi C, Chen G, et al. Integrative analysis of bulk and single-cell gene expression profiles to identify tumor-associated macrophage-derived CCL18 as a therapeutic target of esophageal squamous cell carcinoma. J Exp Clin Cancer Res. 2023;42:51 pubmed publisher

Garc xed a Caballero D, Hart J, Vogt P. The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2. Cell Death Dis. 2023;14:168 pubmed publisher

Yan C, Meng Y, Yang J, Chen J, Jiang W. Translational landscape in human early neural fate determination. Development. 2023;150: pubmed publisher

Shlyakhtina Y, Bloechl B, Portal M. BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity. Nat Commun. 2023;14:1085 pubmed publisher

Ilter D, Drápela S, Schild T, Ward N, Adhikari E, Low V, et al. NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis. Redox Biol. 2023;61:102627 pubmed publisher

Wang J, Urrutia Cabrera D, Lees J, Mesa Mora S, Nguyen T, Hung S, et al. Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes. Int J Mol Sci. 2023;24: pubmed publisher

Lin C, Scheller A, Liu Y, Krause E, Chang H. Study of Effector CD8+ T Cell Interactions with Cortical Neurons in Response to Inflammation in Mouse Brain Slices and Neuronal Cultures. Int J Mol Sci. 2023;24: pubmed publisher

Valiullina A, Zmievskaya E, Ganeeva I, Zhuravleva M, Garanina E, Rizvanov A, et al. Evaluation of CAR-T Cells' Cytotoxicity against Modified Solid Tumor Cell Lines. Biomedicines. 2023;11: pubmed publisher

Parker S, Ly K, Grant A, Sweetland J, Wang A, Parker J, et al. EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons. J Cell Biol. 2023;222: pubmed publisher

Polakowski N, Sarker M, Hoang K, Boateng G, Rushing A, Kendle W, et al. HBZ upregulates myoferlin expression to facilitate HTLV-1 infection. PLoS Pathog. 2023;19:e1011202 pubmed publisher

Huang J, Tan X, Liu Y, Jiang K, Luo J. Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export. Mol Carcinog. 2023;62:700-715 pubmed publisher

Kroken A, Klein K, Mitchell P, Nieto V, Jedel E, Evans D, et al. Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. bioRxiv. 2023;: pubmed publisher

Cicardi M, Hallgren J, Mawrie D, Krishnamurthy K, Markandaiah S, Nelson A, et al. C9orf72 poly(PR) mediated neurodegeneration is associated with nucleolar stress. bioRxiv. 2023;: pubmed publisher

Teryek M, Jadhav P, Bento R, Parekkadan B. 3D Microcapsules for Human Bone Marrow Derived Mesenchymal Stem Cell Biomanufacturing in a Vertical-Wheel Bioreactor. bioRxiv. 2023;: pubmed publisher

Kim D, Kim G, Yu R, Lee J, Kim S, Qiu K, et al. Lymphocyte activation gene 3 (Lag3) supports Foxp3 + Treg cell function by restraining c-Myc-dependent aerobic glycolysis. bioRxiv. 2023;: pubmed publisher

Liu P, Chen Y, Li X, Hsueh P, Tzeng S, Chen H, et al. CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions. Nat Immunol. 2023;24:452-462 pubmed publisher

He L, Shi H, Zhang G, Peng Y, Ghosh A, Zhang M, et al. A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition. J Neurosci. 2023;43:2305-2325 pubmed publisher

Montemagno C, Durivault J, Gastaldi C, Dufies M, Vial V, He X, et al. A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma. Mol Oncol. 2023;17:1379-1401 pubmed publisher

Lee B, Hoyle C, Wellens R, Green J, Martín Sánchez F, Williams D, et al. Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome. Sci Signal. 2023;16:eabm7134 pubmed publisher

Bi J, Jin X, Zheng C, Huang C, Zhong C, Zheng X, et al. Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells. Adv Sci (Weinh). 2023;10:e2207499 pubmed publisher

Ahmed I, Yang S, Ogden S, Zhang W, Li Y, Sharrocks A. eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways. elife. 2023;12: pubmed publisher

Buyukcelebi K, Chen X, Abdula F, Duval A, Ozturk H, Seker Polat F, et al. Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization. Res Sq. 2023;: pubmed publisher

Mohr M, Li S, Trouten A, Stairley R, Roddy P, Liu C, et al. Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. bioRxiv. 2023;: pubmed publisher

Smith F, Kosman D. Frataxin-deficient human brain microvascular endothelial cells lose polymerized actin and are paracellularly permeable -implications for blood-brain barrier integrity in Friedreich's Ataxia. bioRxiv. 2023;: pubmed publisher

Itell H, Humes D, Overbaugh J. Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4 + T cells. bioRxiv. 2023;: pubmed publisher

Lin H, Sandkuhler S, Dunlea C, King D, Johnson G. BAG3 regulates the specificity of the recognition of specific MAPT species by NBR1 and SQSTM1. bioRxiv. 2023;: pubmed publisher

Koeppel J, Weller J, Peets E, Pallaseni A, Kuzmin I, Raudvere U, et al. Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants. Nat Biotechnol. 2023;: pubmed publisher

Nguyen T, Urrutia Cabrera D, Wang L, Lees J, Wang J, Hung S, et al. Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells. Aging (Albany NY). 2023;15:1713-1733 pubmed publisher

Nandi I, Smith H, Sanguin Gendreau V, Ji L, Pacis A, Papavasiliou V, et al. Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. J Clin Invest. 2023;133: pubmed publisher

Kim S, Park C, Lee S, Choi H, Kim C. Reprogramming of IL-12 secretion in the PDCD1 locus improves the anti-tumor activity of NY-ESO-1 TCR-T cells. Front Immunol. 2023;14:1062365 pubmed publisher

Zheng X, Wang M, Liu S, Chen H, Li Y, Yuan F, et al. A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury. Cell Death Dis. 2023;14:126 pubmed publisher

Aw W, Cho C, Wang H, Cooper A, Doherty E, Rocco D, et al. Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation. Sci Adv. 2023;9:eade8939 pubmed publisher

Jin D, Chen X, Liu Y, Williams C, Pedersen L, Stafford D, et al. A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase. Nat Commun. 2023;14:828 pubmed publisher

Huang R, Yamamoto T, Nakata E, Ozaki T, Kurozumi K, Wei F, et al. CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex. Adv Sci (Weinh). 2023;10:e2206542 pubmed publisher

Praharaj P, Patra S, Mishra S, Mukhopadhyay S, Klionsky D, Patil S, et al. CLU (clusterin) promotes mitophagic degradation of MSX2 through an AKT-DNM1L/Drp1 axis to maintain SOX2-mediated stemness in oral cancer stem cells. Autophagy. 2023;19:2196-2216 pubmed publisher

Saad M, Grimaldo Garcia S, Sweeney A, Mallidi S, Hasan T. A Dual Function Antibody Conjugate Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids. bioRxiv. 2023;: pubmed publisher

Collignon E, Cho B, Fothergill Robinson J, Furlan G, Ross R, Limbach P, et al. m 6 A RNA methylation orchestrates transcriptional dormancy during developmental pausing. bioRxiv. 2023;: pubmed publisher

Wang K, Yu Y, Wang W, Jiang Y, Li Y, Jiang X, et al. Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway-driven gastric cancer. Oncogene. 2023;42:1072-1087 pubmed publisher

Wang S, Chen Y, Wu H, Li X, Xiao H, Pan Q, et al. Role of Transcription Factor EB in Mitochondrial Dysfunction of Cisplatin-Induced Acute Kidney Injury. Int J Mol Sci. 2023;24: pubmed publisher

Roy G, Yang T, Liu S, Luo Y, Liu Y, Zhong Q. Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma. Int J Mol Sci. 2023;24: pubmed publisher

Charv xe1 tov xe1 S, Motais B, Czapla J, Cicho x144 T, Smolarczyk R, Walek Z, et al. Novel Local "Off-the-Shelf" Immunotherapy for the Treatment of Myeloma Bone Disease. Cells. 2023;12: pubmed publisher

Yan Y, Gauthier M, Malik A, Fotiadou I, Ostrovski M, Dervovic D, et al. The NOTCH-RIPK4-IRF6-ELOVL4 Axis Suppresses Squamous Cell Carcinoma. Cancers (Basel). 2023;15: pubmed publisher

Papadaki G, Ani O, Florio T, Young M, Danon J, Sun Y, et al. Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules. Front Immunol. 2023;14:1116906 pubmed publisher

Sapozhnikov D, Szyf M. The PROTECTOR strategy employs dCas orthologs to sterically shield off-target sites from CRISPR/Cas activity. Sci Rep. 2023;13:2280 pubmed publisher

Jeong H, Hong E, Ahn J, Cho J, Jeong J, Kim C, et al. ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions. Exp Mol Med. 2023;55:401-412 pubmed publisher

Han D, Liu G, Oh Y, Oh S, Yang S, Mandjikian L, et al. ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells. Nat Commun. 2023;14:632 pubmed publisher

Bai H, Padrón A, Deng Y, Liao Y, Murray C, Ontiveros C, et al. Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects. J Immunother Cancer. 2023;11: pubmed publisher

Loo L, Waller M, Moreno C, Cole A, Stella A, Pop O, et al. Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. PLoS Biol. 2023;21:e3001967 pubmed publisher

Ho W, Mondal I, Xu B, Das O, Sun R, Chiou P, et al. PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages. J Clin Invest. 2023;133: pubmed publisher

Lari A, Glaunsinger B. Murine Gammaherpesvirus 68 ORF45 Stimulates B2 Retrotransposon and Pre-tRNA Activation in a Manner Dependent on Mitogen-Activated Protein Kinase (MAPK) Signaling. Microbiol Spectr. 2023;11:e0017223 pubmed publisher

Lin K, Li L, Ma W, Yang X, Han Z, Luo N, et al. A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing. Neural Regen Res. 2023;18:1827-1833 pubmed publisher

Zou M, Mangum K, Magin J, Cao H, Yarboro M, Shelton E, et al. Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. JCI Insight. 2023;8: pubmed publisher

Sastre D, Zafar F, Torres C, Piper D, Kirik D, Sanders L, et al. Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson's disease. bioRxiv. 2023;: pubmed publisher

White M, Jacobs K, Singh T, Kutys M. Notch1 cortical signaling regulates epithelial architecture and cell-cell adhesion. bioRxiv. 2023;: pubmed publisher

Montoya V, Ready T, Felton A, Fine S, OhAinle M, Emerman M. A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains. MBio. 2023;14:e0000923 pubmed publisher

Rodr xed guez Bl xe1 zquez A, Carabias A, Mor xe1 n Vaquero A, de Cima S, Luque Ortega J, Alfonso C, et al. Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms. Cell Commun Signal. 2023;21:30 pubmed publisher

Golkowski M, Lius A, Sapre T, Lau H, Moreno T, Maly D, et al. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Mol Cell. 2023;83:803-818.e8 pubmed publisher

Rom xe1 n Fern xe1 ndez A, Mansour M, Kugeratski F, Anand J, Sandilands E, Galbraith L, et al. Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Sci Adv. 2023;9:eabq1858 pubmed publisher

Schwartz M, Shnayder M, Nachshon A, Arazi T, Kitsberg Y, Levi Samia R, et al. Molecular characterization of human cytomegalovirus infection with single-cell transcriptomics. Nat Microbiol. 2023;8:455-468 pubmed publisher

Rosspopoff O, Cazottes E, Huret C, Loda A, Collier A, Casanova M, et al. Species-specific regulation of XIST by the JPX/FTX orthologs. Nucleic Acids Res. 2023;51:2177-2194 pubmed publisher

Essletzbichler P, Sedlyarov V, Frommelt F, Soulat D, Heinz L, Stefanovic A, et al. A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery. Life Sci Alliance. 2023;6: pubmed publisher

Boila L, Ghosh S, Bandyopadhyay S, Jin L, Murison A, Zeng A, et al. KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Leukemia. 2023;: pubmed publisher

Frost T, Gartin A, Liu M, Cheng J, Dharaneeswaran H, Keskin D, et al. YAP1 and WWTR1 expression inversely correlates with neuroendocrine markers in Merkel cell carcinoma. J Clin Invest. 2023;133: pubmed publisher

Stein B, Ferrarone J, Gardner E, Chang J, Wu D, Hollstein P, et al. LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer Discov. 2023;13:1002-1025 pubmed publisher

Lin C, Traets J, Vredevoogd D, Visser N, Peeper D. TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling. EMBO J. 2023;42:e111614 pubmed publisher

Campbell S, Chirasani V, Khan M, Malavade J, DOKHOLYAN N, Hoffman B. Elucidation of the Molecular Basis and Cellular Functions of Vinculin-Actin Directional Catch Bonding. Res Sq. 2023;: pubmed publisher

Shoyer T, Gates E, Cabe J, Conway D, Hoffman B. Coupling During Collective Cell Migration is Controlled by a Vinculin Mechanochemical Switch. bioRxiv. 2023;: pubmed publisher

Chakraborty S, Bhat A, Mushtaq I, Luan H, Kalluchi A, Mirza S, et al. EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis. bioRxiv. 2023;: pubmed publisher

Kim Y, Li C, Gu C, Tycksen E, Puri A, Pietka T, et al. MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy. bioRxiv. 2023;: pubmed publisher

Hsieh E, Janssens D, Paddison P, Browne E, Henikoff S, OhAinle M, et al. A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. PLoS Pathog. 2023;19:e1011101 pubmed publisher

Danielson L, Guijarro M, Menendez S, Higgins B, Sun Q, Mittal K, et al. MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcoma. PLoS ONE. 2023;18:e0278844 pubmed publisher

Boos F, Oo J, Warwick T, G xfc nther S, Izquierdo Ponce J, Lopez M, et al. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Basic Res Cardiol. 2023;118:5 pubmed publisher

Zhang Y, Rabinovsky R, Wei Z, El Fatimy R, Deforzh E, Luan B, et al. Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma. Mol Ther Nucleic Acids. 2023;31:265-275 pubmed publisher

Virtanen L, Holm E, Halme M, West G, Lindholm F, Gullmets J, et al. Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress. J Cell Sci. 2023;136: pubmed publisher

Zhou J, Sarkar M, Okamura K, Harris J, Gudjonsson J, Fitzgerald K. Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). Proc Natl Acad Sci U S A. 2023;120:e2213777120 pubmed publisher

Kolluri A, Li D, Li N, Duan Z, Roberts L, Ho M. Human VH-based chimeric antigen receptor T cells targeting glypican 3 eliminate tumors in preclinical models of HCC. Hepatol Commun. 2023;7:e0022 pubmed publisher

Hossain M, Cevallos R, Zhang R, Hu K. Attenuating iPSC reprogramming stress with dominant-negative BET peptides. iScience. 2023;26:105889 pubmed publisher

Young L, Goldstein de Salazar R, Han S, Huang Z, Merk A, Drew M, et al. Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proc Natl Acad Sci U S A. 2023;120:e2208960120 pubmed publisher

Kabirova M, Reichenstein M, Borovok N, Sheinin A, Gorobets D, Michaelevski I. Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization. Cell Mol Neurobiol. 2023;43:2785-2799 pubmed publisher

Peng X, Luo R, Ran X, Guo Y, Yao Y, Qiu M. Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy. Bioorg Chem. 2023;132:106375 pubmed publisher

Tatavosian R, Donovan M, Galbraith M, Duc H, Szwarc M, Joshi M, et al. Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation. Cell Death Differ. 2023;30:952-965 pubmed publisher

Nassar A, Abou Alaiwi S, Baca S, Adib E, Corona R, Seo J, et al. Epigenomic charting and functional annotation of risk loci in renal cell carcinoma. Nat Commun. 2023;14:346 pubmed publisher

Majdalani P, Levitas A, Krymko H, Slanovic L, Braiman A, Hadad U, et al. A Missense Variation in PHACTR2 Associates with Impaired Actin Dynamics, Dilated Cardiomyopathy, and Left Ventricular Non-Compaction in Humans. Int J Mol Sci. 2023;24: pubmed publisher

Yan Y, Zhou Q, Ran X, Lu Q, Zhang C, Peng M, et al. Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology. Int J Mol Sci. 2023;24: pubmed publisher

Wistner S, Macdonald I, Stanley K, Hathaway N. Characterization of Hepatoma-Derived Growth Factor-Related Protein 2 Interactions with Heterochromatin. Cells. 2023;12: pubmed publisher

Hayat A, Carter E, King H, Ors A, Doe A, Teijeiro S, et al. Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin opening. Dis Model Mech. 2023;16: pubmed publisher

Itah Z, Chaudhry S, Raju Ponny S, Aydemir O, Lee A, Cavanagh Kyros J, et al. HER2-driven breast cancer suppression by the JNK signaling pathway. Proc Natl Acad Sci U S A. 2023;120:e2218373120 pubmed publisher

Huet Calderwood C, Rivera Molina F, Toomre D, Calderwood D. Use of Ecto-Tagged Integrins to Monitor Integrin Exocytosis and Endocytosis. Methods Mol Biol. 2023;2608:17-38 pubmed publisher

Tsujino T, Takai T, Hinohara K, Gui F, Tsutsumi T, Bai X, et al. CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer. Nat Commun. 2023;14:252 pubmed publisher

Jiang X, Deng W, Tao S, Tang Z, Chen Y, Tian M, et al. A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma. Cell Discov. 2023;9:7 pubmed publisher

Mathis N, Allam A, Kissling L, Marquart K, Schmidheini L, Solari C, et al. Predicting prime editing efficiency and product purity by deep learning. Nat Biotechnol. 2023;: pubmed publisher

Mendonsa S, von K xfc gelgen N, Dantsuji S, Ron M, Breimann L, Baranovskii A, et al. Massively parallel identification of mRNA localization elements in primary cortical neurons. Nat Neurosci. 2023;26:394-405 pubmed publisher

Arimoto K, Miyauchi S, Troutman T, Zhang Y, Liu M, Stoner S, et al. Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Nat Commun. 2023;14:251 pubmed publisher

Luqman Fatah A, Watanabe Y, Uno K, Ishikawa F, Moran J, Miyoshi T. The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction. Nat Commun. 2023;14:203 pubmed publisher

Qiu H, Makarov V, Bolzenius J, Halstead A, Parker Y, Wang A, et al. KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Cancer Res. 2023;83:814-829 pubmed publisher

Lehmann J, Caduff N, Krzywi x144 ska E, Stierli S, Salas Bastos A, Loos B, et al. Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma. Sci Adv. 2023;9:eadc8825 pubmed publisher

Guo Y, Zhang H, Yan C, Shen B, Zhang Y, Guo X, et al. Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction. Nat Chem Biol. 2023;19:468-477 pubmed publisher

Pedrazza L, Martinez Martinez A, S xe1 nchez de Diego C, Valer J, Pimenta Lopes C, Sala Gaston J, et al. HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling. Cell Death Dis. 2023;14:17 pubmed publisher

Robinson C, Singh G, Kleer M, Katsademas T, Castle E, Boudreau B, et al. Kaposi's sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies. PLoS Pathog. 2023;19:e1011080 pubmed publisher

Fu Y, Xiong S. Exosomes mediate Coxsackievirus B3 transmission and expand the viral tropism. PLoS Pathog. 2023;19:e1011090 pubmed publisher

Mattis K, Krentz N, Metzendorf C, Abaitua F, Spigelman A, Sun H, et al. Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia. 2023;66:674-694 pubmed publisher

Kiseleva A, Cheng Y, Smith C, Katz R, Poleshko A. PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina. Nucleus. 2023;14:2165602 pubmed publisher

Chen Y, Zuo X, Wei Q, Xu J, Liu X, Liu S, et al. Upregulation of LRRC8A by m5C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer. Int J Biol Sci. 2023;19:691-704 pubmed publisher

Suzuki S, Ando F, Kitagawa S, Hara Y, Fujiki T, Mandai S, et al. ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Commun Biol. 2023;6:29 pubmed publisher

Law R, Kiepas A, Desta H, Perez Ipi xf1 a E, Parlani M, Lee S, et al. Cytokinesis machinery promotes cell dissociation from collectively migrating strands in confinement. Sci Adv. 2023;9:eabq6480 pubmed publisher

Lafferty M, Ayg xfc n N, Patel N, Krupa O, Liang D, Wolter J, et al. MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size. elife. 2023;12: pubmed publisher

Madhu V, Hernandez Meadows M, Boneski P, Qiu Y, Guntur A, Kurland I, et al. The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc. Autophagy. 2023;19:1821-1843 pubmed publisher

Nitschke L, Hu R, Miller A, Lucas L, Cooper T. Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function. Nucleic Acids Res. 2023;51:1245-1259 pubmed publisher

Huang Z, Efthymiadou A, Liang N, Fan R, Treuter E. Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4. Nucleic Acids Res. 2023;51:1067-1086 pubmed publisher

Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, et al. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Cell Stem Cell. 2023;30:52-68.e13 pubmed publisher

Wu Y, Clark K, Niranjan B, Ch xfc eh A, Horvath L, Taylor R, et al. Integrative characterisation of secreted factors involved in intercellular communication between prostate epithelial or cancer cells and fibroblasts. Mol Oncol. 2023;17:469-486 pubmed publisher

Omar M, Lauer S, Lau H, Golkowski M, Ong S, Scott J. Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells. STAR Protoc. 2023;4:101992 pubmed publisher

Unda B, Chalil L, Yoon S, Kilpatrick S, Irwin C, Xing S, et al. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Mol Psychiatry. 2023;: pubmed publisher

Leon K, Khalid M, Flynn R, Fontaine K, Nguyen T, Kumar G, et al. Nuclear accumulation of host transcripts during Zika Virus Infection. PLoS Pathog. 2023;19:e1011070 pubmed publisher

Bai W, Zhang Y, Ma J, Du M, Xu H, Wang J, et al. FHL3 promotes the formation of fast glycolytic muscle fibers by interacting with YY1 and muscle glycolytic metabolism. Cell Mol Life Sci. 2023;80:27 pubmed publisher

Luo W, Demidov V, Shen Q, Gir xe3 o H, Chakraborty M, Maiorov A, et al. CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide state-sensitive manner. Sci Adv. 2023;9:eabq5404 pubmed publisher

Ge Y, Lu H, Yang B, Woo C. Small Molecule-Activated O-GlcNAcase for Spatiotemporal Removal of O-GlcNAc in Live Cells. ACS Chem Biol. 2023;: pubmed publisher

Garc xed a Hern xe1 ndez V, Arambilet D, Guill xe9 n Y, Lobo Jarne T, Maqueda M, Gekas C, et al. β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia. EMBO Mol Med. 2023;:e16554 pubmed publisher

Chen S, Paul M, Sterner C, Belka G, Wang D, Xu P, et al. PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies. Breast Cancer Res. 2023;25:1 pubmed publisher

Khan P, Siddiqui J, Kshirsagar P, Venkata R, Maurya S, Mirzapoiazova T, et al. MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis. Mol Cancer. 2023;22:1 pubmed publisher

Bonaud A, Gargowitsch L, Gilbert S, Rajan E, Canales Herrerias P, Stockholm D, et al. Sec22b is a critical and nonredundant regulator of plasma cell maintenance. Proc Natl Acad Sci U S A. 2023;120:e2213056120 pubmed publisher

Martinez A, Kim A, Flores C, Rahman D, Yang W. Mouse embryonic stem cell-derived motor neurons are susceptible to ferroptosis. FEBS Open Bio. 2023;: pubmed publisher

Yoon D, Kim E, Cho S, Jung S, Lee K, Park K, et al. RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes. Int J Biol Sci. 2023;19:13-33 pubmed publisher

Lin D, Li X, Moult E, Park P, Tang B, Shen H, et al. Time-tagged ticker tapes for intracellular recordings. Nat Biotechnol. 2023;: pubmed publisher

Amodio V, Lamba S, Chil xe0 R, Cattaneo C, Mussolin B, Corti G, et al. Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance. Cancer Cell. 2023;41:196-209.e5 pubmed publisher

Miluzio A, Cuomo A, Cordiglieri C, Donnici L, Pesce E, Bombaci M, et al. Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2. EBioMedicine. 2023;87:104390 pubmed publisher

Wu C, Lidsky P, Xiao Y, Cheng R, Lee I, Nakayama T, et al. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Cell. 2023;186:112-130.e20 pubmed publisher

Vierbuchen T, Agarwal S, Johnson J, Galia L, Lei X, Stein K, et al. The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2. Proc Natl Acad Sci U S A. 2023;120:e2213715120 pubmed publisher

Cervia L, Shibue T, Borah A, Gaeta B, He L, Leung L, et al. A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas. Cancer Discov. 2023;13:766-795 pubmed publisher

Collins S, Wiegand M, Werner A, Brown I, Mundo M, Swango D, et al. Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion. Mol Biol Cell. 2023;34:ar9 pubmed publisher

Diab A, Wigerius M, Quinn D, Qi J, Shahin I, Paffile J, et al. NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation. J Neurosci. 2023;43:885-901 pubmed publisher

Grand K, Stoltz M, Rizzo L, R xf6 ck R, Kaminski M, Salinas G, et al. HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes. J Am Soc Nephrol. 2023;34:412-432 pubmed publisher

Kato H, Tateishi K, Iwadate D, Yamamoto K, Fujiwara H, Nakatsuka T, et al. HNF1B-driven three-dimensional chromatin structure for molecular classification in pancreatic cancers. Cancer Sci. 2023;114:1672-1685 pubmed publisher

Trovato F, Stefani F, Li J, Zetterdahl O, Canals I, Ahlenius H, et al. Transcription Factor-Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo. Mol Cancer Ther. 2023;22:274-286 pubmed publisher

Taslim T, Hussein A, Keshri R, Ishibashi J, Chan T, Nguyen B, et al. Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs. Stem Cell Reports. 2023;18:269-288 pubmed publisher

Lidstr xf6 m T, Cumming J, Gaur R, Fr xe4 ngsmyr L, Pateras I, Mickert M, et al. Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer. Cancer Immunol Res. 2023;11:72-92 pubmed publisher

Bacalhau M, Ferreira F, Kmit A, Souza F, da Silva V, Pimentel A, et al. Identification of novel F508del-CFTR traffic correctors among triazole derivatives. Eur J Pharmacol. 2023;938:175396 pubmed publisher

Miyazaki M, Nakabo A, Nagano Y, Nagamura Y, Yanagihara K, Ohki R, et al. Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis. Cancer Lett. 2023;553:215983 pubmed publisher

Binda O, Juillard F, Ducassou J, Kleijwegt C, Paris G, Didillon A, et al. SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members. Life Sci Alliance. 2023;6: pubmed publisher

Polanco J, Akimov Y, Fernandes A, Briner A, Hand G, van Roijen M, et al. CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Life Sci Alliance. 2023;6: pubmed publisher

Vinothkumar K, Chanda S, Singh V, Biswas S, Mohapatra S, Biswas G, et al. EVI1 upregulates PTGS1 (COX1) and decreases the action of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia cells. Int J Hematol. 2023;117:110-120 pubmed publisher

Soto Feliciano Y, S xe1 nchez Rivera F, Perner F, Barrows D, Kastenhuber E, Ho Y, et al. A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition. Cancer Discov. 2023;13:146-169 pubmed publisher

Muscolini M, Hiscott J, Tassone E. A Genome-Wide CRISPR-Cas9 Loss-of-Function Screening to Identify Host Restriction Factors Modulating Oncolytic Virotherapy. Methods Mol Biol. 2023;2589:379-399 pubmed publisher

Cheng R, Li F, Zhang M, Xia X, Wu J, Gao X, et al. A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. Cell Res. 2023;33:30-45 pubmed publisher

Benaglio P, Zhu H, Okino M, Yan J, Elgamal R, Nariai N, et al. Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines. Cell Genom. 2022;2:100214 pubmed publisher

Csukasi F, Bosakova M, Bárta T, Martin J, Arcedo J, Barad M, et al. Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Front Cell Dev Biol. 2022;10:963389 pubmed publisher

Worel N, Grabmeier Pfistershammer K, Kratzer B, Schlager M, Tanzmann A, Rottal A, et al. The frequency of differentiated CD3+CD27-CD28- T cells predicts response to CART cell therapy in diffuse large B-cell lymphoma. Front Immunol. 2022;13:1004703 pubmed publisher

Cappelletto A, Allan H, Crescente M, Schneider E, Bussani R, Ali H, et al. SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity. Front Cardiovasc Med. 2022;9:1013262 pubmed publisher

Park J, Park G, Lee J, Park J, Kim S, Kim E, et al. ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth. Front Mol Biosci. 2022;9:1030725 pubmed publisher

George A, Ravi N, Prasad K, Panigrahi L, Koikkara S, Rajendiran V, et al. Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2. Front Genome Ed. 2022;4:1085111 pubmed publisher

Balta E, Janzen N, Kirchgessner H, Toufaki V, Orlik C, Liang J, et al. Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment. Front Immunol. 2022;13:1063313 pubmed publisher

Palermo E, Alexandridi M, Di Carlo D, Muscolini M, Hiscott J. Virus-like particle - mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection. Front Cell Infect Microbiol. 2022;12:1079926 pubmed publisher

Jiang X, Isogai T, Chi J, Danuser G. Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes. PLoS Comput Biol. 2022;18:e1009667 pubmed publisher

Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K. p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Cell Death Discov. 2022;8:502 pubmed publisher

Hennig P, Di Filippo M, Bilfeld G, Mellett M, Beer H. High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells. Cell Death Dis. 2022;13:1077 pubmed publisher

Kim M, Park J, Kim S, Han D, Shin B, Sch xf6 ler H, et al. Generation of Induced Pluripotent Stem Cells from Lymphoblastoid Cell Lines by Electroporation of Episomal Vectors. Int J Stem Cells. 2022;: pubmed publisher

Iyer K, Mitra A, Mitra D. Identification of 5' upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection. Virus Res. 2022;324:199034 pubmed publisher

Brandimarti R, Irollo E, Meucci O. The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities. Mol Neurobiol. 2022;: pubmed publisher

Xu X, Chan A, Li M, Liu Q, Mattson N, Pangeni Pokharel S, et al. ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Sci Adv. 2022;8:eadc8911 pubmed publisher

Hou Y, Cai Y, Li W, He W, Zhao Z, Zhu W, et al. A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1. Nat Commun. 2022;13:7898 pubmed publisher

Rottner A, Ye Y, Navarro Guerrero E, Rajesh V, Pollner A, Bevacqua R, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk. Nat Genet. 2022;: pubmed publisher

Baker S, Meistermann H, Tzouros M, Baker A, Golling S, Polster J, et al. Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus. PLoS Biol. 2022;20:e3001934 pubmed publisher

Wu F, Li X, Looso M, Liu H, Ding D, G xfc nther S, et al. Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. Nat Genet. 2022;: pubmed publisher

Hosios A, Wilkinson M, McNamara M, Kalafut K, Torrence M, Asara J, et al. mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nat Metab. 2022;4:1792-1811 pubmed publisher

Dolliver S, Kleer M, Bui Marinos M, Ying S, Corcoran J, Khaperskyy D. Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. PLoS Pathog. 2022;18:e1011041 pubmed publisher

Liu Y, Choy M, Abraham S, Tenin G, Black G, Keavney B. Data on cardiac lncRNA STX18-AS1 expression in developing human hearts and function during in vitro hESC-cardiomyocyte differentiation. Data Brief. 2022;45:108770 pubmed publisher

Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, et al. KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell. 2022;: pubmed publisher

Yu B, Shi Q, Belk J, Yost K, Parker K, Li R, et al. Engineered cell entry links receptor biology with single-cell genomics. Cell. 2022;185:4904-4920.e22 pubmed publisher

Brewer W, Xet Mull A, Yu A, Sweeney M, Walton E, Tobin D. Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. Cell Rep. 2022;41:111817 pubmed publisher

Ng W, Kwek S, Sun B, Yousefi M, Ong E, Tan H, et al. A fast-growing dengue virus mutant reveals a dual role of STING in response to infection. Open Biol. 2022;12:220227 pubmed publisher

Kohler J, Omachi K, Charu V, Miner J, Bhalla V. A COL4A4-G394S Variant and Impaired Collagen IV Trimerization in a Patient with Mild Alport Syndrome. Kidney360. 2022;3:1899-1908 pubmed publisher

Zhang Y, Wei W, Li C, Yan S, Wang S, Xiao S, et al. Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein. Cell Death Dis. 2022;13:1034 pubmed publisher

Skobeleva K, Shalygin A, Mikhaylova E, Guzhova I, Ryazantseva M, Kaznacheyeva E. The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2022;23: pubmed publisher

Li Y, Zhao Y, Yan X, Ye C, Weirich S, Zhang B, et al. CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation. Nat Commun. 2022;13:7636 pubmed publisher

Gialesaki S, Br xe4 uer Hartmann D, Issa H, Bhayadia R, Alejo Valle O, Verboon L, et al. RUNX1 isoform disequilibrium promotes the development of trisomy 21 associated myeloid leukemia. Blood. 2022;: pubmed publisher

Chen X, Li J, Zhang R, Zhang Y, Wang X, Leung E, et al. Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels. J Extracell Vesicles. 2022;11:e12279 pubmed publisher

Xiong Q, Cao L, Ma C, Tortorici M, Liu C, Si J, et al. Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Nature. 2022;612:748-757 pubmed publisher

Hertel A, Alves L, Dutz H, Tascher G, Bonn F, Kaulich M, et al. USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction. Cell Rep. 2022;41:111653 pubmed publisher

Dai T, Rosario S, Katsuta E, Sawant Dessai A, Paterson E, Novickis A, et al. Hypoxic activation of PFKFB4 in breast tumor microenvironment shapes metabolic and cellular plasticity to accentuate metastatic competence. Cell Rep. 2022;41:111756 pubmed publisher

Wang Y, Zhao Y, Guo W, Yadav G, Bhaskarla C, Wang Z, et al. Genome-wide gain-of-function screening characterized lncRNA regulators for tumor immune response. Sci Adv. 2022;8:eadd0005 pubmed publisher

Idres Y, Lai A, McMillan N, Idris A. Hyperactivation of p53 using CRISPRa kills human papillomavirus-driven cervical cancer cells. Virus Genes. 2022;: pubmed publisher

Sumya F, Pokrovskaya I, D Souza Z, Lupashin V. Acute COG complex inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles. Traffic. 2022;: pubmed publisher

Ib xe1 xf1 ez Molero S, van Vliet A, Poźniak J, Hummelink K, Terry A, Monkhorst K, et al. SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response. Oncoimmunology. 2022;11:2139074 pubmed publisher

Devlin A, Shukla A, Ruiz J, Barnes S, Govindan A, Hunter O, et al. The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication. Nat Commun. 2022;13:7447 pubmed publisher

Liu X, Sato N, Yabushita T, Li J, Jia Y, Tamura M, et al. IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia. EMBO Mol Med. 2022;:e15631 pubmed publisher

Kneppers J, Severson T, Siefert J, Schol P, Joosten S, Yu I, et al. Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential. Nat Commun. 2022;13:7367 pubmed publisher

Hoshii T, Perlee S, Kikuchi S, Rahmutulla B, Fukuyo M, Masuda T, et al. SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia. Cell Rep. 2022;41:111727 pubmed publisher

Jia S, Zhuo R, Zhang Z, Yang Y, Tao Y, Wang J, et al. The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma. J Immunol Res. 2022;2022:7945884 pubmed publisher

Yi C, He J, Huang D, Zhao Y, Zhang C, Ye X, et al. Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia. Cell Death Dis. 2022;13:1004 pubmed publisher

Radke J, Schumann E, Onken J, Koll R, Acker G, Bodnar B, et al. Decoding molecular programs in melanoma brain metastases. Nat Commun. 2022;13:7304 pubmed publisher

Li A, Muenst S, Hoffman J, Starck L, Sarem M, Fischer A, et al. Mesenchymal-endothelial nexus in breast cancer spheroids induces vasculogenesis and local invasion in a CAM model. Commun Biol. 2022;5:1303 pubmed publisher

Liu J, Zeng D, Luo J, Wang H, Xiong J, Chen X, et al. LPS-Induced Inhibition of miR-143 Expression in Brown Adipocytes Promotes Thermogenesis and Fever. Int J Mol Sci. 2022;23: pubmed publisher

Cao Y, Yan X, Bai X, Tang F, Si P, Bai C, et al. UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling. Cancers (Basel). 2022;14: pubmed publisher

Mendon N, Ganie R, Kesarwani S, Dileep D, Sasi S, Lama P, et al. Nanobody derived using a peptide epitope from the spike protein receptor-binding motif inhibits entry of SARS-CoV-2 variants. J Biol Chem. 2022;299:102732 pubmed publisher

Liu H, Lee C, Hsieh Y, Zheng J, Liu Y, Chang C, et al. Mitochondrial Factor C20orf7 Facilitates the EMT-Mediated Cancer Cell Migration and the Proliferation of Colon Cancer In Vitro and In Vivo. Genes (Basel). 2022;13: pubmed publisher

Farnsworth D, Inoue Y, Johnson F, de Rappard Yuswack G, Lu D, Shi R, et al. MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression. NPJ Precis Oncol. 2022;6:88 pubmed publisher

Rodrigues Lopes I, Alcântara L, Silva R, Josse J, Vega E, Cabrerizo A, et al. Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature. Nat Commun. 2022;13:7174 pubmed publisher

Chen Q, Dai J, Bian Q. Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects. Sci Adv. 2022;8:eabo3648 pubmed publisher

Morris S, Deol K, Lange M, Olzmann J. A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity. Biol Open. 2022;11: pubmed publisher

Aparicio B, Rep xe1 raz D, Ruiz M, Llopiz D, Silva L, Vercher E, et al. Identification of HLA class I-restricted immunogenic neoantigens in triple negative breast cancer. Front Immunol. 2022;13:985886 pubmed publisher

Tesfay L, Paul B, Hegde P, Brewer M, Habbani S, JELLISON E, et al. Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer. Sci Rep. 2022;12:19936 pubmed publisher

Hsu K, Dunleavey J, Szot C, Yang L, Hilton M, Morris K, et al. Cancer cell survival depends on collagen uptake into tumor-associated stroma. Nat Commun. 2022;13:7078 pubmed publisher

Rushdi M, Pan V, Li K, Choi H, Travaglino S, Hong J, et al. Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity. Nat Commun. 2022;13:7055 pubmed publisher

Celebi Torabfam G, Yetisgin A, Erdem C, Cayli A, Kutlu O, Cetinel S. A feasibility study of different commercially available serum-free mediums to enhance lentivirus and adeno-associated virus production in HEK 293 suspension cells. Cytotechnology. 2022;74:635-655 pubmed publisher

McNamara M, Hosios A, Torrence M, Zhao T, Fraser C, Wilkinson M, et al. Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex. iScience. 2022;25:105458 pubmed publisher

Maughan E, Hynds R, Pennycuick A, Nigro E, Gowers K, Denais C, et al. Cell-intrinsic differences between human airway epithelial cells from children and adults. iScience. 2022;25:105409 pubmed publisher

Cui H, Sepehrimanesh M, Coutee C, Akter M, Hosain M, Ding B. Protocol to image and quantify nucleocytoplasmic transport in cultured cells using fluorescent in situ hybridization and a dual reporter system. STAR Protoc. 2022;3:101813 pubmed publisher

SCHMITT M, Ceteci F, Gupta J, Pesic M, B xf6 ttger T, Nicolas A, et al. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Nature. 2022;612:347-353 pubmed publisher

Darragh L, Gadwa J, Pham T, Van Court B, Neupert B, Olimpo N, et al. Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors. Nat Commun. 2022;13:7015 pubmed publisher

Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, et al. SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. PLoS Biol. 2022;20:e3001871 pubmed publisher

Pesch A, Chandler B, Michmerhuizen A, Carter H, Hirsh N, Wilder Romans K, et al. Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression. Cancer Res Commun. 2022;2:679-693 pubmed publisher

Gong Y, Shao H, Li Y, Brafford P, Stine Z, Sun J, et al. Na+/H+-exchanger 1 enhances antitumor activity of engineered NK-92 natural killer cells. Cancer Res Commun. 2022;2:842-856 pubmed publisher

Washer S, Perez Alcantara M, Chen Y, Steer J, James W, Trynka G, et al. Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia. Sci Rep. 2022;12:19454 pubmed publisher

Suzuki C, Fujiwara T, Shima H, Ono K, Saito K, Kato H, et al. Elucidation of the Role of FAM210B in Mitochondrial Metabolism and Erythropoiesis. Mol Cell Biol. 2022;42:e0014322 pubmed publisher

Shozu K, Kaneko S, Shinkai N, Dozen A, Kosuge H, Nakakido M, et al. Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer. Clin Epigenetics. 2022;14:147 pubmed publisher

Tilokani L, Russell F, Hamilton S, Virga D, Segawa M, Paupe V, et al. AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. Sci Adv. 2022;8:eabo7956 pubmed publisher

Kocaturk N, Peker N, Eberhart K, Akkoç Y, Deveci G, Dengjel J, et al. Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy. Cell Death Dis. 2022;13:947 pubmed publisher

Sanz Castillo B, Hurtado B, Vara Ciruelos D, El Bakkali A, Hermida D, Salvador Barbero B, et al. The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. EMBO J. 2022;:e110833 pubmed publisher

Kitaeva K, Chulpanova D, Zhuravleva M, Filin I, Deviatiiarov R, Ballard Reisch A, et al. Characteristics and Resistance to Cisplatin of Human Neuroblastoma Cells Co-Cultivated with Immune and Stromal Cells. Bioengineering (Basel). 2022;9: pubmed publisher

Yi J, Gong X, Yin X, Wang L, Hou J, Chen J, et al. Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells. Front Oncol. 2022;12:988528 pubmed publisher

Yoo H, Choi D, Roh Y, Lee Y, Lim J, Eo S, et al. MsrB1-regulated GAPDH oxidation plays programmatic roles in shaping metabolic and inflammatory signatures during macrophage activation. Cell Rep. 2022;41:111598 pubmed publisher

Chen P, Fiaux P, Zhang K, Li B, Kubo N, Jiang S, et al. Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation. Cell Rep. 2022;41:111630 pubmed publisher

Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler P, Braun A, et al. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022;55:2059-2073.e8 pubmed publisher

Xu T, Verhagen M, Joosten R, Sun W, Sacchetti A, Munoz Sagredo L, et al. Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer. elife. 2022;11: pubmed publisher

Liu S, Cao Y, Cui K, Tang Q, Zhao K. Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops. Nat Commun. 2022;13:6679 pubmed publisher

Grange L, Reynolds J, Ullah F, Isidor B, Shearer R, Latypova X, et al. Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy. Nat Commun. 2022;13:6664 pubmed publisher

Loukas I, Simeoni F, Milan M, Inglese P, Patel H, Goldstone R, et al. Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia. Cancer Cell. 2022;: pubmed publisher

Kantzer C, Yang W, Grommisch D, Vikhe Patil K, Mak K, Shirokova V, et al. ID1 and CEBPA coordinate epidermal progenitor cell differentiation. Development. 2022;149: pubmed publisher

Hanzl A, Casement R, Imrichová H, Hughes S, Barone E, Testa A, et al. Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat Chem Biol. 2022;: pubmed publisher

Kim H, Leng K, Park J, Sorets A, Kim S, Shostak A, et al. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat Commun. 2022;13:6581 pubmed publisher

Yang S, Yamazaki S, Cox K, Huang Y, Miller E, Takahashi J. Coupling-dependent metabolic ultradian rhythms in confluent cells. Proc Natl Acad Sci U S A. 2022;119:e2211142119 pubmed publisher

Singer J, Shew T, Ferguson D, Renkemeyer M, Pietka T, Hall A, et al. Monoacylglycerol O-acyltransferase 1 lowers adipocyte differentiation capacity in vitro but does not affect adiposity in mice. Obesity (Silver Spring). 2022;30:2122-2133 pubmed publisher

Dzhivhuho G, Holsey J, Honeycutt E, O Farrell H, Rekosh D, Hammarskjold M, et al. HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev. Sci Rep. 2022;12:18416 pubmed publisher

Muto Y, DIXON E, Yoshimura Y, Wu H, Omachi K, Ledru N, et al. Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis. Nat Commun. 2022;13:6497 pubmed publisher

Cadavid J, Latour S, Nowlan F, Co I, Landon Brace N, Wouters B, et al. An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype. Adv Healthc Mater. 2022;:e2201846 pubmed publisher

Coelho R, Tozzi A, Disler M, Lombardo F, Fedier A, L xf3 pez M, et al. Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer. Cell Death Dis. 2022;13:909 pubmed publisher

Dai Q, Zhang L, Sun H, Pajdzik K, Yang L, Ye C, et al. Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution. Nat Biotechnol. 2022;: pubmed publisher

Cavounidis A, Pandey S, Capitani M, Friedrich M, Cross A, Gartner L, et al. Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism. Mucosal Immunol. 2022;15:1431-1446 pubmed publisher

Jim xe9 nez Villegas J, Kirby J, Mata A, Cadenas S, Turner M, Malaspina A, et al. Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance. Antioxidants (Basel). 2022;11: pubmed publisher

O Brien S, Kelso S, Steinhart Z, Orlicky S, Mis M, Kim Y, et al. SCFFBXW7 regulates G2-M progression through control of CCNL1 ubiquitination. EMBO Rep. 2022;23:e55044 pubmed publisher

Li M, Han Y, Wang C, Kang W, Jiang W, Zhang L, et al. Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma. J Exp Clin Cancer Res. 2022;41:311 pubmed publisher

Burke M, Scott J, Minshull T, Gao Z, Manfield I, Savic S, et al. A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins. J Biol Chem. 2022;298:102624 pubmed publisher

Zhang X, Jiang Q, Li J, Zhang S, Cao Y, Xia X, et al. KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA-DNA triplexes and HP1 binding. Nat Cell Biol. 2022;24:1617-1629 pubmed publisher

Wang Y, Leng X, Zhou C, Lu S, Tsang C, Xu J, et al. Non-enzymatic role of SOD1 in intestinal stem cell growth. Cell Death Dis. 2022;13:882 pubmed publisher

McSweeney D, Gabriel R, Jin K, Pang Z, Aronow B, Pak C. CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons. iScience. 2022;25:105187 pubmed publisher

Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, et al. Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Cell Rep. 2022;41:111514 pubmed publisher

Morizako N, Butlertanaka E, Tanaka Y, Shibata H, Okabayashi T, Mekata H, et al. Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector. Sci Rep. 2022;12:16952 pubmed publisher

Wehling L, Keegan L, Fern xe1 ndez Palanca P, Hassan R, Ghallab A, Schmitt J, et al. Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury. elife. 2022;11: pubmed publisher

Tabtieng T, Lent R, Kaku M, Monago Sanchez A, Gaglia M. Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi's Sarcoma-Associated Herpesvirus Infection. MBio. 2022;13:e0244622 pubmed publisher

Cao G, Ma L, Zhang Z, Wang X, Hua J, Zhang J, et al. Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors. Acta Pharmacol Sin. 2022;: pubmed publisher

Zhang Y, Li Y, Thompson K, Stoletov K, Yuan Q, Bera K, et al. Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis. Nat Commun. 2022;13:6128 pubmed publisher

Chen S, Ma B, Li X, Zhang K, Wei Y, Du B, et al. MYC-mediated silencing of miR-181a-5p promotes pathogenic Th17 responses by modulating AKT3-FOXO3 signaling. iScience. 2022;25:105176 pubmed publisher

Chen C, Zhang Z, Liu C, Wang B, Liu P, Fang S, et al. ATF4-dependent fructolysis fuels growth of glioblastoma multiforme. Nat Commun. 2022;13:6108 pubmed publisher

Sala Gaston J, Pedrazza L, Ramirez J, Martinez Martinez A, Rawlins L, Baple E, et al. HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress. Cell Mol Life Sci. 2022;79:548 pubmed publisher

Zhang M, Kuznetsoff J, Owens D, Gallo R, Kalahasty K, Cruz A, et al. Early Mechanisms of Chemoresistance in Retinoblastoma. Cancers (Basel). 2022;14: pubmed publisher

Sheta R, Teixeira M, Idi W, Pierre M, de Rus Jacquet A, Emond V, et al. Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons. Sci Rep. 2022;12:17176 pubmed publisher

Song J, Chow R, Pe xf1 a Hern xe1 ndez M, Zhang L, Loeb S, So E, et al. LRRC15 inhibits SARS-CoV-2 cellular entry in trans. PLoS Biol. 2022;20:e3001805 pubmed publisher

Courchaine E, Gelles Watnick S, Machyna M, Straube K, Sauyet S, Enright J, et al. The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies. Nat Commun. 2022;13:6005 pubmed publisher

Durrant M, Fanton A, Tycko J, Hinks M, Chandrasekaran S, Perry N, et al. Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome. Nat Biotechnol. 2022;: pubmed publisher

Kim J, Jozic A, Mukherjee A, Nelson D, Chiem K, Khan M, et al. Rapid Generation of Circulating and Mucosal Decoy Human ACE2 using mRNA Nanotherapeutics for the Potential Treatment of SARS-CoV-2. Adv Sci (Weinh). 2022;9:e2202556 pubmed publisher

Colbert J, Cruz F, Baer C, Rock K. Tetraspanin-5-mediated MHC class I clustering is required for optimal CD8 T cell activation. Proc Natl Acad Sci U S A. 2022;119:e2122188119 pubmed publisher

Lemay J, St Hilaire E, Ronato D, Gao Y, B xe9 langer F, Gezzar Dandashi S, et al. A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response. PLoS Biol. 2022;20:e3001543 pubmed publisher

Xiao L, Wang L, Wu C, Li H, Zhang Q, Wang Y, et al. Controllable DNA hybridization by host-guest complexation-mediated ligand invasion. Nat Commun. 2022;13:5936 pubmed publisher

Wang X, Liu Y, Ding Y, Feng G. CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway. Sci Rep. 2022;12:16899 pubmed publisher

Boland S, Swarup S, Ambaw Y, Malia P, Richards R, Fischer A, et al. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022;13:5924 pubmed publisher

Banerjee T, Biswas D, Pal D, Miao Y, Iglesias P, Devreotes P. Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration. Nat Cell Biol. 2022;24:1499-1515 pubmed publisher

Zhang Z, Ding Y, Ezhilarasan R, Lhakhang T, Wang Q, Yang J, et al. Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma. Cell Discov. 2022;8:102 pubmed publisher

Thaler R, Khani F, Sturmlechner I, Dehghani S, Denbeigh J, Zhou X, et al. Vitamin C epigenetically controls osteogenesis and bone mineralization. Nat Commun. 2022;13:5883 pubmed publisher

Sasaya T, Kubo T, Murata K, Mizue Y, Sasaki K, Yanagawa J, et al. Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma. Cancer Med. 2022;: pubmed publisher

Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, et al. Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration. iScience. 2022;25:105050 pubmed publisher

Willis J, Berndsen Z, Ma K, Steichen J, Schiffner T, Landais E, et al. Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors. Immunity. 2022;55:2149-2167.e9 pubmed publisher

Pag xe8 s D, Dornier E, de Seze J, Gontran E, Maitra A, Maciejewski A, et al. Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments. Sci Adv. 2022;8:eabp8416 pubmed publisher

Gimbel A, Koziarek S, Theodorou K, Schulz J, Stanicek L, Kremer V, et al. Aging-regulated TUG1 is dispensable for endothelial cell function. PLoS ONE. 2022;17:e0265160 pubmed publisher

Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Castro L, et al. Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. bioRxiv. 2022;: pubmed publisher

Liang X, Zhang Y, He Y, Liu X, Ding Z, Zhang X, et al. A cancer stem cell associated gene signature for predicting overall survival of hepatocellular carcinoma. Front Genet. 2022;13:888601 pubmed publisher

Carter C, Mast F, Olivier J, Bourgeois N, Kaushansky A, Aitchison J. Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication. Front Cell Infect Microbiol. 2022;12:979996 pubmed publisher

Ma L, Wang J, Zhang Y, Fang F, Ling J, Chu X, et al. BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes. Cancer Biol Ther. 2022;23:1-15 pubmed publisher

Haridhasapavalan K, Sundaravadivelu P, Joshi N, Das N, Mohapatra A, Voorkara U, et al. Generation of a recombinant version of a biologically active cell-permeant human HAND2 transcription factor from E. coli. Sci Rep. 2022;12:16129 pubmed publisher

Ambrosini C, Destefanis E, Kheir E, Broso F, Alessandrini F, Longhi S, et al. Translational enhancement by base editing of the Kozak sequence rescues haploinsufficiency. Nucleic Acids Res. 2022;50:10756-10771 pubmed publisher

Trolle J, McBee R, Kaufman A, Pinglay S, Berger H, German S, et al. Resurrecting essential amino acid biosynthesis in mammalian cells. elife. 2022;11: pubmed publisher

Cronk J, Dziewulska K, Puchalski P, Crittenden R, Hammarskj xf6 ld M, Brown M. Altered-Self MHC Class I Sensing via Functionally Disparate Paired NK Cell Receptors Counters Murine Cytomegalovirus gp34-Mediated Immune Evasion. J Immunol. 2022;209:1545-1554 pubmed publisher

Escobar M, Li J, Patel A, Liu S, Xu Q, Hilton I. Quantification of Genome Editing and Transcriptional Control Capabilities Reveals Hierarchies among Diverse CRISPR/Cas Systems in Human Cells. ACS Synth Biol. 2022;11:3239-3250 pubmed publisher

Bao C, Duan J, Xie Y, Liu Y, Li P, Li J, et al. A novel oncogenic enhancer of estrogen receptor-positive breast cancer. Mol Ther Nucleic Acids. 2022;29:836-851 pubmed publisher

Salimi Jeda A, Esghaei M, Hossein Keyvani -, Bokharaei Salim F, Teimoori A, Abdoli A. Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy. Heliyon. 2022;8:e10483 pubmed publisher

Ogden S, Carys K, Ahmed I, Bruce J, Sharrocks A. Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition. Oncogene. 2022;41:4808-4822 pubmed publisher

M xfc ller P, Rocks O. A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity. STAR Protoc. 2022;3:101705 pubmed publisher

Jiang A, Zhang S, Wang X, Li D. RBM15 condensates modulate m6A modification of STYK1 to promote tumorigenesis. Comput Struct Biotechnol J. 2022;20:4825-4836 pubmed publisher

Brasu N, Elia I, Russo V, Montacchiesi G, Stabile S, De Intinis C, et al. Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination. Nat Immunol. 2022;23:1445-1456 pubmed publisher

Zeng X, Zhao F, Cui G, Zhang Y, Deshpande R, Chen Y, et al. METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Nat Cancer. 2022;3:1088-1104 pubmed publisher

Badarinath K, Dam B, Kataria S, Zirmire R, Dey R, Kansagara G, et al. Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. Cell Rep. 2022;40:111390 pubmed publisher

McKinney A, Mathur R, Stevers N, Molinaro A, Chang S, Phillips J, et al. GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. Cell Rep. 2022;40:111344 pubmed publisher

Ugalde A, Bretones G, Rodr xed guez D, Quesada V, Llorente F, Fern xe1 ndez Delgado R, et al. Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cells. EMBO J. 2022;41:e110727 pubmed publisher

Pringle E, Duguay B, Bui Marinos M, Mulloy R, Landreth S, Desireddy K, et al. Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions. PLoS Pathog. 2022;18:e1010832 pubmed publisher

Sun D, Llorà Batlle O, van den Ameele J, Thomas J, He P, Lim K, et al. SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling. EMBO J. 2022;41:e111338 pubmed publisher

Butler M, Vervoort B, van Ingen Schenau D, Jongeneel L, van der Zwet J, Marke R, et al. Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways. Front Oncol. 2022;12:905665 pubmed publisher

Yang Y, Bolomsky A, Oellerich T, Chen P, Ceribelli M, H xe4 upl B, et al. Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma. Nat Commun. 2022;13:5469 pubmed publisher

Cordes T, Kuna R, McGregor G, Khare S, Gengatharan J, Muthusamy T, et al. 1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells. J Lipid Res. 2022;63:100281 pubmed publisher

Qi S, Sivakumar S, Yu H. CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation. STAR Protoc. 2022;3:101682 pubmed publisher

Rebsamen M, Girardi E, Sedlyarov V, Scorzoni S, Papakostas K, Vollert M, et al. Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions. Life Sci Alliance. 2022;5: pubmed publisher

Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce J, et al. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell. 2022;40:1111-1127.e9 pubmed publisher

Wuchu F, Ma X, Que Y, Chen J, Ruan Y. Biphasic regulation of CFTR expression by ENaC in epithelial cells: The involvement of Ca2+-modulated cAMP production. Front Cell Dev Biol. 2022;10:781762 pubmed publisher

Friskes A, Koob L, Krenning L, Severson T, Koeleman E, Vergara X, et al. Double-strand break toxicity is chromatin context independent. Nucleic Acids Res. 2022;50:9930-9947 pubmed publisher

Khokhlatchev A, Sharma A, Deering T, Shaw J, Costa Pinheiro P, Golla U, et al. Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia. FASEB J. 2022;36:e22514 pubmed publisher

Lauko A, Volovetz J, Turaga S, Bayık D, Silver D, Mitchell K, et al. SerpinB3 drives cancer stem cell survival in glioblastoma. Cell Rep. 2022;40:111348 pubmed publisher

Sokoya T, Parolek J, Foged M, Danylchuk D, Bozan M, Sarkar B, et al. Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. elife. 2022;11: pubmed publisher

Glorieux C, Xia X, You X, Wang Z, Han Y, Yang J, et al. Cisplatin and gemcitabine exert opposite effects on immunotherapy with PD-1 antibody in K-ras-driven cancer. J Adv Res. 2022;40:109-124 pubmed publisher

van Gils N, Verhagen H, Broux M, Marti xe1 xf1 ez T, Denkers F, Vermue E, et al. Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters. iScience. 2022;25:105013 pubmed publisher

Abdul F, Diman A, Baechler B, Ramakrishnan D, Kornyeyev D, Beran R, et al. Smc5/6 silences episomal transcription by a three-step function. Nat Struct Mol Biol. 2022;29:922-931 pubmed publisher

Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, et al. GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Nat Commun. 2022;13:5351 pubmed publisher

Pond K, Morris J, Alkhimenok O, Varghese R, Cabel C, Ellis N, et al. Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis. elife. 2022;11: pubmed publisher

Vaquero Siguero N, Schleussner N, Volk J, Mastel M, Meier J, Jackstadt R. Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection. Cancers (Basel). 2022;14: pubmed publisher

El Abdellaoui Soussi F, Yunes Leites P, L xf3 pez Maderuelo D, Garc xed a Marqu xe9 s F, V xe1 zquez J, Redondo J, et al. Interplay between the Chd4/NuRD Complex and the Transcription Factor Znf219 Controls Cardiac Cell Identity. Int J Mol Sci. 2022;23: pubmed publisher

Damkham N, Lorthongpanich C, Klaihmon P, Lueangamornnara U, Kheolamai P, Trakarnsanga K, et al. YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation. Stem Cell Res Ther. 2022;13:467 pubmed publisher

Soutar M, Melandri D, O Callaghan B, Annuario E, Monaghan A, Welsh N, et al. Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci. Brain. 2022;145:4349-4367 pubmed publisher

Baca S, Singler C, Zacharia S, Seo J, Morova T, Hach F, et al. Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation. Nat Genet. 2022;54:1364-1375 pubmed publisher

Hojo H, Saito T, He X, Guo Q, Onodera S, Azuma T, et al. Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages. Cell Rep. 2022;40:111315 pubmed publisher

Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio S, et al. Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma. Acta Neuropathol. 2022;144:1027-1048 pubmed publisher

Wilson P, Muto Y, Wu H, Karihaloo A, Waikar S, Humphreys B. Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression. Nat Commun. 2022;13:5253 pubmed publisher

Pogacar Z, Johnson J, Krenning L, De Conti G, Jochems F, Lieftink C, et al. Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity. PLoS ONE. 2022;17:e0273182 pubmed publisher

Zou R, Marin Gonzalez A, Liu Y, Liu H, Shen L, Dveirin R, et al. Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites. Nat Cell Biol. 2022;24:1433-1444 pubmed publisher

Tang S, Wu X, Liu J, Zhang Q, Wang X, Shao S, et al. Generation of dual-gRNA library for combinatorial CRISPR screening of synthetic lethal gene pairs. STAR Protoc. 2022;3:101556 pubmed publisher

Skoko J, Cao J, Gaboriau D, Attar M, Asan A, Hong L, et al. Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1. Redox Biol. 2022;56:102443 pubmed publisher

Wang C, Yu X, Ding S, Liu Y, Zhang H, Fu J, et al. Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF. Cell Biosci. 2022;12:143 pubmed publisher

Michaelis J, Brunstein M, Bozkurt S, Alves L, Wegner M, Kaulich M, et al. Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy. Nat Commun. 2022;13:5164 pubmed publisher

Li X, Kordsmeier J, Nookaew I, Kim H, Xiong J. Piezo1 stimulates mitochondrial function via cAMP signaling. FASEB J. 2022;36:e22519 pubmed publisher

Molenaar T, Malik M, Silva J, Liu N, Haarhuis J, Ambrosi C, et al. The histone methyltransferase SETD2 negatively regulates cell size. J Cell Sci. 2022;135: pubmed publisher

Bergmann T, Liu Y, Skov J, Mogus L, Lee J, Pfisterer U, et al. Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming. Front Cell Dev Biol. 2022;10:976549 pubmed publisher

Yuskaitis C, Modasia J, Schr xf6 tter S, Rossitto L, Groff K, Morici C, et al. DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting. Cell Rep. 2022;40:111278 pubmed publisher

Casteels T, Bajew S, Reini x161 J, Enders L, Schuster M, Fontaine F, et al. SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression. Cell Rep. 2022;40:111288 pubmed publisher

Li S, Patel J, Yang J, Crabtree A, Rubenstein B, Lund Andersen P, et al. Defining the HIV Capsid Binding Site of Nucleoporin 153. mSphere. 2022;7:e0031022 pubmed publisher

Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed publisher

Martin Gallausiaux C, García Weber D, Lashermes A, Larraufie P, Marinelli L, Teixeira V, et al. Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway. Gut Microbes. 2022;14:2110639 pubmed publisher

Yamamoto H, Abe K. Protocol for viral vector-mediated measurement of transcription factor activity of mouse brain. STAR Protoc. 2022;3:101633 pubmed publisher

Rios Garcia M, Meissburger B, Chan J, de Guia R, Mattijssen F, Roessler S, et al. Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death. Adv Sci (Weinh). 2022;9:e2104291 pubmed publisher

Iketani S, Hong S, Sheng J, Bahari F, Culbertson B, Atanaki F, et al. Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites. Cell Host Microbe. 2022;30:1354-1362.e6 pubmed publisher

Wang Y, Feng Y, Gan Y, Teng L, Wang L, La T, et al. LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma. J Exp Clin Cancer Res. 2022;41:260 pubmed publisher

Ochi T, Fujiwara T, Ono K, Suzuki C, Nikaido M, Inoue D, et al. Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome. Sci Rep. 2022;12:14562 pubmed publisher

Hinds J, Feris E, Wilkins O, Deary L, Wang X, Cole M. S146L in MYC is a context-dependent activating substitution in cancer development. PLoS ONE. 2022;17:e0272771 pubmed publisher

Zhong G, Wang Q, Wang Y, Guo Y, Xu M, Guan Y, et al. scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity. Oncoimmunology. 2022;11:2114740 pubmed publisher

Frey K, Goetze S, Rohrer L, von Eckardstein A, Wollscheid B. Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions. Int J Mol Sci. 2022;23: pubmed publisher

Ariyachet C, Chuaypen N, Kaewsapsak P, Chantaravisoot N, Jindatip D, Potikanond S, et al. MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury. Int J Mol Sci. 2022;23: pubmed publisher

Iacomi D, Rosca A, Tutuianu R, Neagu T, Pruna V, Simionescu M, et al. Generation of an Immortalized Human Adipose-Derived Mesenchymal Stromal Cell Line Suitable for Wound Healing Therapy. Int J Mol Sci. 2022;23: pubmed publisher

Zhang M, Qiu H, Mao L, Wang B, Li N, Fan Y, et al. Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells. Cell Death Dis. 2022;13:733 pubmed publisher

Gonschior H, Schmied C, Van der Veen R, Eichhorst J, Himmerkus N, Piontek J, et al. Nanoscale segregation of channel and barrier claudins enables paracellular ion flux. Nat Commun. 2022;13:4985 pubmed publisher

Carnevale J, Shifrut E, Kale N, Nyberg W, Blaeschke F, Chen Y, et al. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022;609:174-182 pubmed publisher

D Souza L, Wright S, Bhattacharya D. Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters. PLoS ONE. 2022;17:e0261801 pubmed publisher

Kleer M, Mulloy R, Robinson C, Evseev D, Bui Marinos M, Castle E, et al. Human coronaviruses disassemble processing bodies. PLoS Pathog. 2022;18:e1010724 pubmed publisher

Ibarra I, Ratnu V, Gordillo L, Hwang I, Mariani L, Weinand K, et al. Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements. Mol Syst Biol. 2022;18:e10473 pubmed publisher

Volkmar N, Gawden Bone C, Williamson J, Nixon Abell J, West J, St George Hyslop P, et al. Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. EMBO J. 2022;41:e110777 pubmed publisher

Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, et al. RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1. Autophagy. 2022;:1-17 pubmed publisher

Patten J, Keiser P, Morselli Gysi D, Menichetti G, Mori H, Donahue C, et al. Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization. iScience. 2022;25:104925 pubmed publisher

Phillips S, Baek A, Kim S, Chen S, Wu L. Protocol for the generation of HIV-1 genomic RNA with altered levels of N 6-methyladenosine. STAR Protoc. 2022;3:101616 pubmed publisher

Tarazi S, Aguilera Castrejon A, Joubran C, Ghanem N, Ashouokhi S, Roncato F, et al. Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell. 2022;185:3290-3306.e25 pubmed publisher

Shivalingappa P, Singh D, Sharma V, Arora V, Shiras A, Bapat S. RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation. Stem Cell Rev Rep. 2022;:1-16 pubmed publisher

Shi D, Savani M, Levitt M, Wang A, Endress J, Bird C, et al. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell. 2022;40:939-956.e16 pubmed publisher

Zhou H, Guan Q, Hou X, Liu L, Zhou L, Li W, et al. Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells. Int J Biol Sci. 2022;18:4869-4883 pubmed publisher

Bagchi A, Devaraju N, Chambayil K, Rajendiran V, Venkatesan V, Sayed N, et al. Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications. Sci Rep. 2022;12:14033 pubmed publisher

Cumin C, Huang Y, Rossdam C, Ruoff F, C xe9 spedes S, Liang C, et al. Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways. Cell Rep. 2022;40:111181 pubmed publisher

Gros M, Segura E, Rookhuizen D, Baudon B, Heurtebise Chr xe9 tien S, Burgdorf N, et al. Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation. Cell Rep. 2022;40:111205 pubmed publisher

Khateb M, Perovanovic J, Ko K, Jiang K, Feng X, Acevedo Luna N, et al. Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution. Cell Rep. 2022;40:111219 pubmed publisher

Wong D, Xiao J, Chew T, Pan M, Lee C, Ang J, et al. BNIP-2 Activation of Cellular Contractility Inactivates YAP for H9c2 Cardiomyoblast Differentiation. Adv Sci (Weinh). 2022;9:e2202834 pubmed publisher

Azadbakht M, Sayadmanesh A, Nazer N, Ahmadi A, Hemmati S, Mohammadzade H, et al. CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells. Bioimpacts. 2022;12:337-347 pubmed publisher

Bo Z, Huang S, Li L, Chen L, Chen P, Luo X, et al. EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes. BMC Cardiovasc Disord. 2022;22:373 pubmed publisher

Miljkovic J, Burger N, Gawel J, Mulvey J, Norman A, Nishimura T, et al. Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biol. 2022;55:102429 pubmed publisher

Sang X, Zhang Y, Fang F, Gao L, Tao Y, Li X, et al. BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia. J Immunol Res. 2022;2022:7912484 pubmed publisher

Rao D, Yu C, Wang T, Sheng J, Lv E, Liang H, et al. Pan-cancer analysis combined with experimental validation revealed IL4I1 as an immunological and prognostic biomarker. Int Immunopharmacol. 2022;111:109091 pubmed publisher

Kuppe C, Ramirez Flores R, Li Z, Hayat S, Levinson R, Liao X, et al. Spatial multi-omic map of human myocardial infarction. Nature. 2022;608:766-777 pubmed publisher

Castrogiovanni C, Inchingolo A, Harrison J, Dudka D, Sen O, Burroughs N, et al. Evidence for a HURP/EB free mixed-nucleotide zone in kinetochore-microtubules. Nat Commun. 2022;13:4704 pubmed publisher

Zhang H, Domma A, Goodrum F, Moorman N, Kamil J. The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication. MBio. 2022;13:e0104222 pubmed publisher

Pietrobono S, De Paolo R, Mangiameli D, Marranci A, Battisti I, Franchin C, et al. p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells. J Biol Chem. 2022;298:102353 pubmed publisher

Pontel L, Bueno Costa A, Morellato A, Carvalho Santos J, Rou xe9 G, Esteller M. Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing. Redox Biol. 2022;55:102408 pubmed publisher

de Groot A, Myers K, Krueger T, Brennen W, Amend S, Pienta K. Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype. Neoplasia. 2022;32:100830 pubmed publisher

Karlowitz R, Stanifer M, Roedig J, Andrieux G, Bojkova D, Bechtel M, et al. USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING. Cell Death Dis. 2022;13:684 pubmed publisher

Goudreault M, Gagn xe9 V, Jo C, Singh S, Killoran R, Gingras A, et al. Afadin couples RAS GTPases to the polarity rheostat Scribble. Nat Commun. 2022;13:4562 pubmed publisher

Xiao Q, Zhang X, Tu L, Cao J, Hinrichs C, Su X. Size-dependent activation of CAR-T cells. Sci Immunol. 2022;7:eabl3995 pubmed publisher

Diehl F, Miettinen T, Elbashir R, Nabel C, Darnell A, Do B, et al. Nucleotide imbalance decouples cell growth from cell proliferation. Nat Cell Biol. 2022;24:1252-1264 pubmed publisher

Cao L, Morgun E, Genardi S, Visvabharathy L, Cui Y, Huang H, et al. METTL14-dependent m6A modification controls iNKT cell development and function. Cell Rep. 2022;40:111156 pubmed publisher

Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature. 2022;608:778-783 pubmed publisher

Choi Y, Luo Y, Lee S, Jin H, Yoon H, Hahn Y, et al. FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res. 2022;50:8929-8946 pubmed publisher

Park B, Yoo J, Heo S, Kim M, Lee K, Song Y. A CRISPR-Cas12a-based diagnostic method for multiple genotypes of severe fever with thrombocytopenia syndrome virus. PLoS Negl Trop Dis. 2022;16:e0010666 pubmed publisher

S xe1 nchez S xe1 nchez J, Vicente Garc xed a C, Ca xf1 ada Garc xed a D, Mart xed n Zanca D, Ar xe9 valo J. ARMS/Kidins220 regulates nociception by controlling brain-derived neurotrophic factor secretion. Pain. 2022;: pubmed publisher

Hsu Y, Yin Y, Tsai K, Jian C, Liang Z, Hsu C, et al. TGFBR3 supports anoikis through suppressing ATF4 signaling. J Cell Sci. 2022;135: pubmed publisher

Ning N, Zhang S, Wu Q, Li X, Kuang D, Duan Y, et al. Inhibition of acylglycerol kinase sensitizes DLBCL to venetoclax via upregulation of FOXO1-mediated BCL-2 expression. Theranostics. 2022;12:5537-5550 pubmed publisher

Fang M, Zhang A, Du Y, Lu W, Wang J, Minze L, et al. TRIM18 is a critical regulator of viral myocarditis and organ inflammation. J Biomed Sci. 2022;29:55 pubmed publisher

Na Z, Dai X, Zheng S, Bryant C, Loh K, Su H, et al. Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Mol Cell. 2022;82:2900-2911.e7 pubmed publisher

Perelroizen R, Philosof B, Budick Harmelin N, Chernobylsky T, Ron A, Katzir R, et al. Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity. Brain. 2022;145:3288-3307 pubmed publisher

Bell E, Shah P, Zuela Sopilniak N, Kim D, Varlet A, Morival J, et al. Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer. Oncogene. 2022;41:4211-4230 pubmed publisher

Roelle S, Shukla N, Pham A, Bruchez A, Matreyek K. Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains. PLoS Biol. 2022;20:e3001738 pubmed publisher

Compagnone M, Pinto E, Salvatori E, Lione L, Conforti A, Marchese S, et al. DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model. Vaccines (Basel). 2022;10: pubmed publisher

Thinard R, Farkas A, Halasa M, Chevalier M, Brodaczewska K, Majewska A, et al. "Endothelial Antibody Factory" at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases. Pharmaceutics. 2022;14: pubmed publisher

Alewine G, Knight J, Ghantae A, Mamrega C, Attiah B, Coover R, et al. Silver Nanoparticles Selectively Treat Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors in a Neurofibromin-Dependent Manner. J Pers Med. 2022;12: pubmed publisher

de Mendoza A, Nguyen T, Ford E, Poppe D, Buckberry S, Pflueger J, et al. Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability. Genome Biol. 2022;23:163 pubmed publisher

Amen A, Loughran R, Huang C, Lew R, Ravi A, Guan Y, et al. Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. Cell Rep Methods. 2022;2:100239 pubmed publisher

Chen Z, Hao W, Tang J, Gao W, Xu H. CSTF2 Promotes Hepatocarcinogenesis and Hepatocellular Carcinoma Progression via Aerobic Glycolysis. Front Oncol. 2022;12:897804 pubmed publisher

Kelly M, Wisniewska K, Regner M, Lewis M, Perreault A, Davis E, et al. A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. Nat Commun. 2022;13:4247 pubmed publisher

Feng D, Gao P, Henley N, Dubuissez M, Chen N, Laurin L, et al. SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin. Cell Death Dis. 2022;13:639 pubmed publisher

Jin Y, Anbarchian T, Wu P, Sarkar A, Fish M, Peng W, et al. Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade. Proc Natl Acad Sci U S A. 2022;119:e2203849119 pubmed publisher

G xfc nther S, Mart xed nez Romero C, Sempere Borau M, Pham C, Garc xed a Sastre A, Stertz S. Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza. Microbiol Spectr. 2022;10:e0092122 pubmed publisher

Krokowski D, Jobava R, Szkop K, Chen C, Fu X, Venus S, et al. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Cell Rep. 2022;40:111092 pubmed publisher

Janssen M, Schmidt C, Bruch P, Blank M, Rohde C, Waclawiczek A, et al. Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1. Blood. 2022;140:2594-2610 pubmed publisher

Goob G, Adrian J, Cossu C, Hauck C. Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ. J Biol Chem. 2022;298:102269 pubmed publisher

Zou Y, Zheng Q, Jiang B, Liu Y, Xu Y, Ma L, et al. Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1. Cell Death Dis. 2022;13:618 pubmed publisher

Ferguson I, Pati xf1 o Escobar B, Tuomivaara S, Lin Y, Nix M, Leung K, et al. The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nat Commun. 2022;13:4121 pubmed publisher

Darp R, Vittoria M, Ganem N, Ceol C. Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nat Commun. 2022;13:4109 pubmed publisher

Ma L, Zou R, Shi W, Zhou N, Chen S, Zhou H, et al. SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways. Theranostics. 2022;12:5034-5050 pubmed publisher

Lu Y, Mu Y, Chen J, Guan X, Guo L, Wu C. CLP36 promotes p53 deficient sarcoma progression through suppression of atrophin-1 interacting protein-4 (AIP-4)-dependent degradation of YAP1. Theranostics. 2022;12:5051-5068 pubmed publisher

Cho Y, Yoon Y, Im H, Son Y, Kim M, Saha A, et al. Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. Nat Commun. 2022;13:4084 pubmed publisher

Omar M, Byrne D, Jones K, Lakey T, Collins K, Lee K, et al. Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep. 2022;40:111073 pubmed publisher

Staels F, Lorenzetti F, De Keukeleere K, Willemsen M, Gerbaux M, Neumann J, et al. A Novel Homozygous Stop Mutation in IL23R Causes Mendelian Susceptibility to Mycobacterial Disease. J Clin Immunol. 2022;42:1638-1652 pubmed publisher

Fauser J, Huyot V, Matsche J, Szynal B, Alexeev Y, Kota P, et al. Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity. J Cell Biol. 2022;221: pubmed publisher

Zhukovsky N, Silvano M, Filloux T, Gonzalez S, Krause K. Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition. Int J Mol Sci. 2022;23: pubmed publisher

Yang H, Liu B, Liu D, Yang Z, Zhang S, Xu P, et al. Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer. Cancers (Basel). 2022;14: pubmed publisher

Sayed S, Sidorova O, Hennig A, Augsburg M, Cortes Vesga C, Abohawya M, et al. Efficient correction of oncogenic KRAS and TP53 mutations through CRISPR base editing. Cancer Res. 2022;: pubmed publisher

Ananthapadmanabhan V, Frost T, Soroko K, Knott A, Magliozzi B, Gokhale P, et al. Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma. JCI Insight. 2022;7: pubmed publisher

Wolzak K, Nölle A, Farina M, Abbink T, van der Knaap M, Verhage M, et al. Neuron-specific translational control shift ensures proteostatic resilience during ER stress. EMBO J. 2022;:e110501 pubmed publisher

Feng Z, Hom M, Bearrood T, Rosenthal Z, Fernandez D, Ondrus A, et al. Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nat Chem Biol. 2022;: pubmed publisher

Bogaert A, Fijalkowska D, Staes A, Van de Steene T, Demol H, Gevaert K. Limited evidence for protein products of non-coding transcripts in the HEK293T cellular cytosol. Mol Cell Proteomics. 2022;:100264 pubmed publisher

Gandhi A, Yu J, Gupta A, Guo T, Iyengar P, Infante R. Cytokine-Mediated STAT3 Transcription Supports ATGL/CGI-58-Dependent Adipocyte Lipolysis in Cancer Cachexia. Front Oncol. 2022;12:841758 pubmed publisher

Kim S, Park H, Oh B. Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. Comput Struct Biotechnol J. 2022;20:3019-3029 pubmed publisher

Forsythe S, Sivakumar H, Erali R, Wajih N, Li W, Shen P, et al. Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications. Ann Surg Oncol. 2022;29:7354-7367 pubmed publisher

Chavan S, Khuperkar D, Lonare A, Panigrahi S, Bellare J, Rapole S, et al. RanGTPase links nucleo-cytoplasmic transport to the recruitment of cargoes into small extracellular vesicles. Cell Mol Life Sci. 2022;79:392 pubmed publisher

Xiang Q, Yang Z, Nicholas J. STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling. PLoS Pathog. 2022;18:e1010676 pubmed publisher

Tan H, Lu G, Dong H, Cho Y, Natalia A, Wang L, et al. A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Nat Commun. 2022;13:3720 pubmed publisher

Sellar R, Sperling A, Słabicki M, Gasser J, McConkey M, Donovan K, et al. Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells. J Clin Invest. 2022;: pubmed publisher

Dai Z, Guo W, Yu D, Zhu X, Sun S, Huang H, et al. SECISBP2L-mediated selenoprotein synthesis is essential for autonomous regulation of oligodendrocyte differentiation. J Neurosci. 2022;: pubmed publisher

Fagundes R, Bourgonje A, Hu S, Barbieri R, Jansen B, Sinnema N, et al. HIF1α-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease. Front Physiol. 2022;13:889091 pubmed publisher

Zhu J, Ma X, Jing Y, Zhang G, Zhang D, Mao Z, et al. P4HB UFMylation regulates mitochondrial function and oxidative stress. Free Radic Biol Med. 2022;188:277-286 pubmed publisher

Yuan B, Zhou X, Suzuki K, Ramos Mandujano G, Wang M, Tehseen M, et al. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nat Commun. 2022;13:3646 pubmed publisher

Sayed S, Sürün D, Mircetic J, Sidorova O, Buchholz F. Using CRISPR-Cas9 to Dissect Cancer Mutations in Cell Lines. Methods Mol Biol. 2022;2508:235-260 pubmed publisher

Zhang Z, Yi J, Xie B, Chen J, Zhang X, Wang L, et al. Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells. Curr Issues Mol Biol. 2022;44:2759-2771 pubmed publisher

Hou R, Yu Y, Sluter M, Li L, Hao J, Fang J, et al. Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma. Cell Rep. 2022;39:111000 pubmed publisher

Wilcock D, Badrock A, Wong C, Owen R, Guerin M, Southam A, et al. Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Cell Rep. 2022;39:110995 pubmed publisher

Liu Z, Nan Y, Luo Q, Wu X, Liu S, Zhao P, et al. DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma. Cancer Res. 2022;: pubmed publisher

Fang F, Cao W, Mu Y, Okuyama H, Li L, Qiu J, et al. IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression. JCI Insight. 2022;7: pubmed publisher

Ong Y, Andrade J, Armbruster M, Shi C, Castro M, Costa A, et al. A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth. Nat Metab. 2022;4:672-682 pubmed publisher

Akkoç Y, Dalci K, Karakas H, Erbil Bilir S, Yalav O, Sakman G, et al. Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of stroma-assisted and autophagy-dependent breast cancer cell migration, invasion and metastasis. Autophagy. 2022;:1-18 pubmed publisher

Singh N, Benoit M, Zhou J, Das B, Davila Velderrain J, Kellis M, et al. BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1. Sci Adv. 2022;8:eabo1286 pubmed publisher

Lee J, Sung K, Joo S, Jeong J, Kim S, Lee H. Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis. Nat Commun. 2022;13:3396 pubmed publisher

Ha T, Diprima M, Koparde V, Jailwala P, Ohnuki H, Feng J, et al. Antisense transcription from lentiviral gene targeting linked to an integrated stress response in colorectal cancer cells. Mol Ther Nucleic Acids. 2022;28:877-891 pubmed publisher

Li J, Shen H, Owens G, Guo L. SREBP1 regulates Lgals3 activation in response to cholesterol loading. Mol Ther Nucleic Acids. 2022;28:892-909 pubmed publisher

Guendisch U, Loos B, Cheng P, Dummer R, Levesque M, Varum S, et al. Loss of YY1, a Regulator of Metabolism in Melanoma, Drives Melanoma Cell Invasiveness and Metastasis Formation. Front Cell Dev Biol. 2022;10:916033 pubmed publisher

Guo Z, Liu X, Chen M. Defining pervasive transcription units using chromatin RNA-sequencing data. STAR Protoc. 2022;3:101442 pubmed publisher

Li N, Du H, Mao L, Xu G, Zhang M, Fan Y, et al. Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles. J Nanobiotechnology. 2022;20:270 pubmed publisher

Xu B, Zhang C, Jiang A, Zhang X, Liang F, Wang X, et al. Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation. J Biol Chem. 2022;:102115 pubmed publisher

Lim E, Chan Y, Dawes P, Guo X, Erdin S, Tai D, et al. Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder. Nat Commun. 2022;13:3243 pubmed publisher

Yang H, Ting X, Geng Y, Xie Y, Nierenberg J, Huo Y, et al. The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. Sci Adv. 2022;8:eabn3509 pubmed publisher

Malacarne P, Bezzenberger J, Lopez M, Warwick T, Müller N, Brandes R, et al. Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone. Int J Mol Sci. 2022;23: pubmed publisher

Gallardo A, Molina A, Asenjo H, López Onieva L, Martorell Marugan J, Espinosa Martinez M, et al. EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization. Oncogene. 2022;41:3611-3624 pubmed publisher

Lu Z, Ni K, Wang Y, Zhou Y, Li Y, Yan J, et al. An in-library ligation strategy and its application in CRISPR/Cas9 screening of high-order gRNA combinations. Nucleic Acids Res. 2022;: pubmed publisher

Lindqvist B, Jütte B, Love L, Assi W, Roux J, Sonnerborg A, et al. T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin. PLoS Pathog. 2022;18:e1010555 pubmed publisher

Yang L, Chen S, Xia J, Zhou Y, Peng L, Fan H, et al. Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection. Cell Biosci. 2022;12:81 pubmed publisher

Li X, Michels B, Tosun O, Jung J, Kappes J, Ibing S, et al. 5'isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1. J Exp Clin Cancer Res. 2022;41:190 pubmed publisher

Liu X, Mei W, Padmanaban V, Alwaseem H, Molina H, Passarelli M, et al. A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs. Mol Cell. 2022;: pubmed publisher

Kong X, Kapustka A, Sullivan B, Schwarz G, Leckband D. Extracellular matrix regulates force transduction at VE-cadherin junctions. Mol Biol Cell. 2022;:mbcE22030075 pubmed publisher

Sanchez Priego C, Hu R, Boshans L, Lalli M, Janas J, Williams S, et al. Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs. Cell Rep. 2022;39:110877 pubmed publisher

Gorbea C, Elhakiem A, Cazalla D. Allosteric regulation of noncoding RNA function by microRNAs. Nucleic Acids Res. 2022;50:6511-6520 pubmed publisher

Chanda M, Shudde C, Piper T, Zheng Y, Courtney A. Combined analysis of T cell activation and T cell-mediated cytotoxicity by imaging cytometry. J Immunol Methods. 2022;506:113290 pubmed publisher

Fedier A, Maggi N, Tozzi A, Disler M, Coelho R, Jacob F, et al. Exposure to escalating olaparib does not induce acquired resistance to PARPi and to other chemotherapeutic compounds in ovarian cancer cell lines. Int J Oncol. 2022;61: pubmed publisher

Metselaar D, du Chatinier A, Meel M, Ter Huizen G, Waranecki P, Goulding J, et al. AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma. iScience. 2022;25:104398 pubmed publisher

Xiong Y, Li Y, Cui X, Zhang L, Yang X, Liu H. ADAP restraint of STAT1 signaling regulates macrophage phagocytosis in immune thrombocytopenia. Cell Mol Immunol. 2022;: pubmed publisher

Yao Q, Xie Y, Xu D, Qu Z, Wu J, Zhou Y, et al. Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3. Cell Mol Immunol. 2022;19:883-897 pubmed publisher

Sun Y, Yang Y, Hu Y, Ouyang L, Sun Z, Yin X, et al. Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death. Redox Biol. 2022;53:102334 pubmed publisher

Lu Y, Wang J, Tang F, Pratap U, Sareddy G, Dhandapani K, et al. Regulation and Role of Neuron-Derived Hemoglobin in the Mouse Hippocampus. Int J Mol Sci. 2022;23: pubmed publisher

Zhu X, Ma J, Lu M, Liu Z, Sun Y, Chen H. The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor. Genes (Basel). 2022;13: pubmed publisher

Lastra D, Escoll M, Cuadrado A. Transcription Factor NRF2 Participates in Cell Cycle Progression at the Level of G1/S and Mitotic Checkpoints. Antioxidants (Basel). 2022;11: pubmed publisher

Gangopadhyay A, Devi S, Tenguria S, Carrière J, Nguyen H, Jäger E, et al. NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. Nat Immunol. 2022;23:892-903 pubmed publisher

Poświata A, Kozik K, Miaczynska M, Zdżalik Bielecka D. Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation. Cell Mol Life Sci. 2022;79:316 pubmed publisher

Michmerhuizen A, Lerner L, Ward C, Pesch A, Zhang A, Schwartz R, et al. Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer. Br J Cancer. 2022;: pubmed publisher

Li W, Chen J, Sun C, Sparks R, Pantano L, Rahman R, et al. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. elife. 2022;11: pubmed publisher

Park S, Uchida T, Tilson S, Hu Z, Ma C, Leek M, et al. A dual conditional CRISPR-Cas9 system to activate gene editing and reduce off-target effects in human stem cells. Mol Ther Nucleic Acids. 2022;28:656-669 pubmed publisher

Sheng D, Ma W, Zhang R, Zhou L, Deng Q, Tu J, et al. Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization. J Immunother Cancer. 2022;10: pubmed publisher

Sorci M, Fink T, Sharma V, Singh S, Chen R, Arduini B, et al. Virucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings. ACS Appl Mater Interfaces. 2022;14:25135-25146 pubmed publisher

Pferdehirt L, Damato A, Dudek M, Meng Q, Herzog E, Guilak F. Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1-induced inflammation. Sci Adv. 2022;8:eabj8892 pubmed publisher

Xu W, Liu C, Deng B, Lin P, Sun Z, Liu A, et al. TP53-inducible putative long noncoding RNAs encode functional polypeptides that suppress cell proliferation. Genome Res. 2022;32:1026-1041 pubmed publisher

Jin X, Li L, Peng Q, Gan C, Gao L, He S, et al. Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2. iScience. 2022;25:104349 pubmed publisher

Serna R, Ramrakhiani A, Hernández J, Chen C, Nakagawa C, Machida T, et al. c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity. iScience. 2022;25:104325 pubmed publisher

Zhu D, Han F, Sun L, Agnihotri S, Hu Y, Bueler H. Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission. Front Oncol. 2022;12:893396 pubmed publisher

Vanhulle E, Stroobants J, Provinciael B, Camps A, Noppen S, Maes P, et al. SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening. Antiviral Res. 2022;203:105342 pubmed publisher

Planès R, Pinilla M, Santoni K, Hessel A, Passemar C, Lay K, et al. Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells. Mol Cell. 2022;82:2385-2400.e9 pubmed publisher

Chen R, Yang Z, Liu J, Cai X, Huo Y, Zhang Z, et al. Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants. Genome Med. 2022;14:53 pubmed publisher

Breyne K, Ughetto S, Rufino Ramos D, Mahjoum S, Grandell E, de Almeida L, et al. Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins. Commun Biol. 2022;5:485 pubmed publisher

Prüller J, Figeac N, Zammit P. DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts. Sci Rep. 2022;12:8388 pubmed publisher

Yuan Q, Gao X. Multiplex base- and prime-editing with drive-and-process CRISPR arrays. Nat Commun. 2022;13:2771 pubmed publisher

Dong X, Zhang X, Liu P, Tian Y, Li L, Gong P. Lipolysis-Stimulated Lipoprotein Receptor Impairs Hepatocellular Carcinoma and Inhibits the Oncogenic Activity of YAP1 via PPPY Motif. Front Oncol. 2022;12:896412 pubmed publisher

Demirbag Sarikaya S, Akkoç Y, Turgut S, Erbil Bilir S, Kocaturk N, Dengjel J, et al. A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Sci Rep. 2022;12:8134 pubmed publisher

Soflaee M, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, et al. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun. 2022;13:2698 pubmed publisher

Duclaux Loras R, Lebreton C, Berthelet J, Charbit Henrion F, Nicolle O, Revenu de Courtils C, et al. UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. J Clin Invest. 2022;132: pubmed publisher

Beltzig L, Schwarzenbach C, Leukel P, Frauenknecht K, Sommer C, Tancredi A, et al. Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells. Cancers (Basel). 2022;14: pubmed publisher

Filipponi D, Pagnuzzi Boncompagni M, Pages G. Inhibiting ALK2/ALK3 Signaling to Differentiate and Chemo-Sensitize Medulloblastoma. Cancers (Basel). 2022;14: pubmed publisher

Pellegrino R, Castoldi M, Ticconi F, Skawran B, Budczies J, Rose F, et al. LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma. Cells. 2022;11: pubmed publisher

Garreta E, Prado P, Stanifer M, Monteil V, Marco A, Ullate Agote A, et al. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. Cell Metab. 2022;34:857-873.e9 pubmed publisher

Lee K, Lin C, Servetto A, Bae J, Kandagatla V, Ye D, et al. Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer. Cancer Immunol Res. 2022;10:829-843 pubmed publisher

Khodeer S, Klungland A, Dahl J. ALKBH5 regulates somatic cell reprogramming in a phase-specific manner. J Cell Sci. 2022;135: pubmed publisher

Torres J, Ozorowski G, Andreano E, Liu H, Copps J, Piccini G, et al. Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody. Proc Natl Acad Sci U S A. 2022;119:e2120976119 pubmed publisher

Xie Y, Wang Y, Xu Z, Lu Y, Song D, Gao L, et al. Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma. J Biomed Sci. 2022;29:32 pubmed publisher

Hortle E, Tran V, Wright K, Fontaine A, Pinello N, O Rourke M, et al. OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Life Sci Alliance. 2022;5: pubmed publisher

Kumar A, Lyu Y, Yanagihashi Y, Chantarasrivong C, Majerciak V, Salemi M, et al. KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4. Cell Rep. 2022;39:110788 pubmed publisher

Wang Y, Liu B, Lu H, Liu J, Romanienko P, Montelione G, et al. SETD4-mediated KU70 methylation suppresses apoptosis. Cell Rep. 2022;39:110794 pubmed publisher

Jacquemin G, Wurmser A, Huyghe M, Sun W, Homayed Z, Merle C, et al. Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme. elife. 2022;11: pubmed publisher

Dong C, Fu S, Karvas R, Chew B, Fischer L, Xing X, et al. A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells. Nat Commun. 2022;13:2548 pubmed publisher

Kuchler O, Gerlach J, Vomhof T, Hettich J, Steinmetz J, Gebhardt J, et al. Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation. Open Biol. 2022;12:210383 pubmed publisher

Aubrey B, Cutler J, Bourgeois W, Donovan K, Gu S, Hatton C, et al. IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Nat Cancer. 2022;3:595-613 pubmed publisher

Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, et al. Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. Nat Metab. 2022;4:575-588 pubmed publisher

Pereira P, Mandleywala K, Monette S, Lumish M, Tully K, Panikar S, et al. Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer. Nat Commun. 2022;13:2526 pubmed publisher

Pogacar Z, Groot K, Jochems F, Dos Santos Dias M, Mulero S xe1 nchez A, Morris B, et al. Genetic and compound screens uncover factors modulating cancer cell response to indisulam. Life Sci Alliance. 2022;5: pubmed publisher

Gao W, Wang Y, Yu S, Wang Z, Ma T, Chan A, et al. Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells. Stem Cell Res Ther. 2022;13:188 pubmed publisher

Singh T, Beatty A, Peterson J. The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells. Cell Death Discov. 2022;8:253 pubmed publisher

So J, Lewis A, Smith L, Stanley K, Franich R, Yoannidis D, et al. Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia. EMBO Mol Med. 2022;14:e15203 pubmed publisher

Meijering A, Sarlós K, Nielsen C, Witt H, Harju J, Kerklingh E, et al. Nonlinear mechanics of human mitotic chromosomes. Nature. 2022;605:545-550 pubmed publisher

Mac Kain A, Maarifi G, Aicher S, Arhel N, Baidaliuk A, Munier S, et al. Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Nat Commun. 2022;13:2442 pubmed publisher

Ding S, Hsu C, Wang Z, Natesh N, Millen R, Negrete M, et al. Patient-derived micro-organospheres enable clinical precision oncology. Cell Stem Cell. 2022;29:905-917.e6 pubmed publisher

Bohnsack J, Zhang H, Wandling G, He D, Kyzar E, Lasek A, et al. Targeted epigenomic editing ameliorates adult anxiety and excessive drinking after adolescent alcohol exposure. Sci Adv. 2022;8:eabn2748 pubmed publisher

Liu Z, Chen T, Zhang S, Yang T, Gong Y, Deng H, et al. Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals. elife. 2022;11: pubmed publisher

Liu J, Knopp K, Rackaityte E, Wang C, Laurie M, Sunshine S, et al. Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus. MBio. 2022;13:e0020522 pubmed publisher

Zhang Y, Trang V, Palmer D, Kishton R, Gong L, Huang J, et al. A T cell resilience model associated with response to immunotherapy in multiple tumor types. Nat Med. 2022;: pubmed publisher

Papes F, Camargo A, de Souza J, Carvalho V, Szeto R, LaMontagne E, et al. Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Nat Commun. 2022;13:2387 pubmed publisher

Hemming M, Benson M, Loycano M, Anderson J, Andersen J, Taddei M, et al. MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor. Cancer Discov. 2022;12:1804-1823 pubmed publisher

Wang H, Wang P, Zhu B. Mechanism of Erastin-Induced Ferroptosis in MDA-MB-231 Human Breast Cancer Cells: Evidence for a Critical Role of Protein Disulfide Isomerase. Mol Cell Biol. 2022;42:e0052221 pubmed publisher

Wu L, Liu L, Xu B, Huang D, Chen X. In vitro and in vivo assay of the ER lipid scramblase TMEM41B. STAR Protoc. 2022;3:101333 pubmed publisher

Sun C, Wu G, Zhang Z, Cao R, Cui S. Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve Injury via the STING-IFN-I Pathway. Front Mol Neurosci. 2022;15:859166 pubmed publisher

Palacios Prado N, Soto P, L xf3 pez X, Choi E, Márquez Miranda V, Rojas M, et al. Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Proc Natl Acad Sci U S A. 2022;119:e2202104119 pubmed publisher

Ferrandiz N, Downie L, Starling G, Royle S. Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes. J Cell Biol. 2022;221: pubmed publisher

Alborzinia H, Flórez A, Kreth S, Brückner L, Yildiz U, Gartlgruber M, et al. MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. Nat Cancer. 2022;3:471-485 pubmed publisher

Liu W, Gajendran B, Sample K, Wang C, Hu A, Chen B, et al. A critical ETV4/Twist1/Vimentin axis in Ha-RAS-induced aggressive breast cancer. Cancer Gene Ther. 2022;: pubmed publisher

Xu X, Shobuike T, Shiraki M, Kamohara A, Hirata H, Murayama M, et al. Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger protein (OCZF) overexpression promotes osteoclast survival by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by the RNA binding protein SAM68. Lab Invest. 2022;: pubmed publisher

Yu P, Guo J, Li J, Shi X, Xu N, Jiang Y, et al. lncRNA-H19 in Fibroblasts Promotes Wound Healing in Diabetes. Diabetes. 2022;71:1562-1578 pubmed publisher

Nair V, Mayer J, Vincendeau M. A protocol for CRISPR-mediated activation and repression of human endogenous retroviruses in human pluripotent stem cells. STAR Protoc. 2022;3:101281 pubmed publisher

Yadav M, Atala A, Lu B. Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression. Int J Biol Macromol. 2022;209:1260-1270 pubmed publisher

Lemster A, Sievers E, Pasternack H, Lazar Karsten P, Klümper N, Sailer V, et al. Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMT. Cancers (Basel). 2022;14: pubmed publisher

Norambuena A, Sun X, Wallrabe H, Cao R, Sun N, Pardo E, et al. SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers. Neurobiol Dis. 2022;169:105737 pubmed publisher

Zhang T, Zheng R, Li M, Yan C, Lan X, Tong B, et al. Active endogenous retroviral elements in human pluripotent stem cells play a role in regulating host gene expression. Nucleic Acids Res. 2022;50:4959-4973 pubmed publisher

Wu L, Shukla V, Yadavalli A, Dinesh R, Xu D, Rao A, et al. HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Genes Dev. 2022;36:433-450 pubmed publisher

Piao W, Li L, Saxena V, Iyyathurai J, Lakhan R, Zhang Y, et al. PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration. Nat Commun. 2022;13:2176 pubmed publisher

Zechner C, Henne W, Sathe A, Xing C, Hernandez G, Sun S, et al. Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT. J Biol Chem. 2022;298:101945 pubmed publisher

Shan B, Barker C, Shao M, Zhang Q, Gupta R, Wu Y. Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. Cell Metab. 2022;34:783-799.e7 pubmed publisher

Solvik T, Nguyen T, Tony Lin Y, Marsh T, Huang E, Wiita A, et al. Secretory autophagy maintains proteostasis upon lysosome inhibition. J Cell Biol. 2022;221: pubmed publisher

Liao S, Wang K, Zhang L, Shi G, Wang Z, Chen Z, et al. PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells. Front Cell Dev Biol. 2022;10:864051 pubmed publisher

Misek S, Foda B, Dexheimer T, Akram M, Conrad S, Schmidt J, et al. BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors. Front Oncol. 2022;12:766794 pubmed publisher

Su Z, Monshaugen I, Wilson B, Wang F, Klungland A, Ougland R, et al. TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Nat Commun. 2022;13:2165 pubmed publisher

Eichler M, Distler U, Nasrullah U, Krishnan A, Kaulich M, Husnjak K, et al. The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions. Cell Death Dis. 2022;13:386 pubmed publisher

Morales E, Arnaiz C, Krystofiak E, Zanic M, Tyska M. Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli. Cell Rep. 2022;39:110692 pubmed publisher

de Rooij M, Thus Y, Swier N, Beijersbergen R, Pals S, Spaargaren M. A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways. Nat Commun. 2022;13:2136 pubmed publisher

Erdem A, Marin S, Pereira Martins D, Geugien M, Cunningham A, Pruis M, et al. Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. Nat Commun. 2022;13:2013 pubmed publisher

Llimos G, Gardeux V, Koch U, Kribelbauer J, Hafner A, Alpern D, et al. A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation. Nat Commun. 2022;13:2042 pubmed publisher

Nelson J, Thin M, Evan T, Howell S, Wu M, Almeida B, et al. USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer. Nat Commun. 2022;13:2070 pubmed publisher

Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, et al. DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nat Commun. 2022;13:2059 pubmed publisher

Flamand M, Meyer K. m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Nucleic Acids Res. 2022;50:4464-4483 pubmed publisher

Francesconi O, Donnici L, Fragai M, Pesce E, Bombaci M, Fasciani A, et al. Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2. iScience. 2022;25:104239 pubmed publisher

Zhang S, Gong T, Nan Y, Feng R, Liu Z, Chen H. MAFB promotes the malignant phenotypes by IGFBP6 in esophageal squamous cell carcinomas. Exp Cell Res. 2022;416:113158 pubmed publisher

Anadon C, Yu X, Hänggi K, Biswas S, Chaurio R, Martin A, et al. Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Cancer Cell. 2022;40:545-557.e13 pubmed publisher

Danziger O, Patel R, DeGrace E, Rosen M, Rosenberg B. Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor. PLoS Pathog. 2022;18:e1010464 pubmed publisher

Guo D, Yu X, Wang D, Li Z, Zhou Y, Xu G, et al. SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71 Infection. J Virol. 2022;96:e0204221 pubmed publisher

Millette M, Holland E, Tenpas T, Dent E. A Single Transcript Knockdown-Replacement Strategy Employing 5' UTR Secondary Structures to Precisely Titrate Rescue Protein Translation. Front Genome Ed. 2022;4:803375 pubmed publisher

Muralimanoharan S, Shamby R, Stansbury N, Schenken R, de la Peña Avalos B, Javanmardi S, et al. Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids. Sci Rep. 2022;12:6169 pubmed publisher

Sakamoto T, Batmanov K, Wan S, Guo Y, Lai L, Vega R, et al. The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation. Nat Commun. 2022;13:1991 pubmed publisher

Carnazza K, Komer L, Xie Y, Pineda A, Briano J, Gao V, et al. Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins. Cell Rep. 2022;39:110675 pubmed publisher

Ohno S, Oikawa K, Tsurui T, Harada Y, Ono K, Tateishi M, et al. Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex. Cell Rep. 2022;39:110673 pubmed publisher

Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, et al. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Sci Adv. 2022;8:eabk2376 pubmed publisher

Passanha F, Geuens T, LaPointe V. Cadherin-11 influences differentiation in human mesenchymal stem cells by regulating the extracellular matrix via the TGFβ1 pathway. Stem Cells. 2022;: pubmed publisher

Vicente Acosta A, Gimenez Cassina A, Diaz Nido J, Loría F. The smoothened agonist SAG reduces mitochondrial dysfunction and neurotoxicity of frataxin-deficient astrocytes. J Neuroinflammation. 2022;19:93 pubmed publisher

Li X, Chen W, Huang L, Zhu M, Zhang H, Si Y, et al. Sinomenine hydrochloride suppresses the stemness of breast cancer stem cells by inhibiting Wnt signaling pathway through down-regulation of WNT10B. Pharmacol Res. 2022;179:106222 pubmed publisher

Xuan W, Hsu W, Khan F, Dunterman M, Pang L, Wainwright D, et al. Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022;10:770-784 pubmed publisher

Zhang Y, Donaher J, Das S, Li X, Reinhardt F, Krall J, et al. Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Nat Cell Biol. 2022;24:554-564 pubmed publisher

Ke P, Chang C, Hsiao Y. Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Cells. 2022;11: pubmed publisher

Lewis M, Wisniewska K, King C, Li S, Coffey A, Kelly M, et al. Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher

Pladevall Morera D, Castejón Griñán M, Aguilera P, Gaardahl K, Ingham A, Brosnan Cashman J, et al. ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors. Cancers (Basel). 2022;14: pubmed publisher

Treese C, Werchan J, von Winterfeld M, Berg E, Hummel M, Timm L, et al. Inhibition of MACC1-Induced Metastasis in Esophageal and Gastric Adenocarcinomas. Cancers (Basel). 2022;14: pubmed publisher

Wang X, Wang R, Jiang K, Zhu M, Guo L, Wu C. PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex. Theranostics. 2022;12:2613-2630 pubmed publisher

Ahamad S, Ali H, Secco I, Giacca M, Gupta D. Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction. Front Genet. 2022;13:866474 pubmed publisher

Cai S, Zheng Z, Cheng J, Zhong L, Shao R, Zheng F, et al. Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit African Swine Fever Virus Replication. Front Immunol. 2022;13:827709 pubmed publisher

Haddock S, Alban T, Turcan S, Husic H, Rosiek E, Ma X, et al. Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells. Neoplasia. 2022;28:100790 pubmed publisher

Dobson C, Reich A, Gaglione S, Smith B, Kim E, Dong J, et al. Antigen identification and high-throughput interaction mapping by reprogramming viral entry. Nat Methods. 2022;19:449-460 pubmed publisher

Apriamashvili G, Vredevoogd D, Krijgsman O, Bleijerveld O, Ligtenberg M, de Bruijn B, et al. Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling. Nat Commun. 2022;13:1923 pubmed publisher

Masgras I, Cannino G, Ciscato F, Sanchez Martin C, Darvishi F, Scantamburlo F, et al. Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3. Cell Death Differ. 2022;: pubmed publisher

Mateo F, He Z, Mei L, de Garibay G, Herranz C, Garcia N, et al. Modification of BRCA1-associated breast cancer risk by HMMR overexpression. Nat Commun. 2022;13:1895 pubmed publisher

Liu H, Iketani S, Zask A, Khanizeman N, Bednářová E, Forouhar F, et al. Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun. 2022;13:1891 pubmed publisher

Deforzh E, Uhlmann E, Das E, Galitsyna A, Arora R, Saravanan H, et al. Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma. Mol Cell. 2022;82:1894-1908.e5 pubmed publisher

Gill D, Parry A, Santos F, Okkenhaug H, Todd C, Hernando Herraez I, et al. Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. elife. 2022;11: pubmed publisher

Marivin A, Ho R, Garcia Marcos M. DAPLE orchestrates apical actomyosin assembly from junctional polarity complexes. J Cell Biol. 2022;221: pubmed publisher

Niekamp P, Scharte F, Sokoya T, Vittadello L, Kim Y, Deng Y, et al. Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair. Nat Commun. 2022;13:1875 pubmed publisher

Zhou T, Zhu X, Ye Z, Wang Y, Yao C, Xu N, et al. Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery. Nat Commun. 2022;13:1855 pubmed publisher

Zhang G, Liu Y, Huang S, Qu S, Cheng D, Yao Y, et al. Enhancement of prime editing via xrRNA motif-joined pegRNA. Nat Commun. 2022;13:1856 pubmed publisher

Minervina A, Pogorelyy M, Kirk A, Crawford J, Allen E, Chou C, et al. SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells. Nat Immunol. 2022;23:781-790 pubmed publisher

Yang Y, Lu W, Ning M, Zhou X, Wan X, Mi Q, et al. A functional SNP rs895819 on pre-miR-27a is associated with bipolar disorder by targeting NCAM1. Commun Biol. 2022;5:309 pubmed publisher

Dansu D, Liang J, Selcen I, Zheng H, Moore D, CASACCIA P. PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells. Front Cell Neurosci. 2022;16:820226 pubmed publisher

Gomes A, Ilter D, Low V, Drápela S, Schild T, Mullarky E, et al. Altered propionate metabolism contributes to tumour progression and aggressiveness. Nat Metab. 2022;4:435-443 pubmed publisher

Wang E, Dai Y, Rosen C, Schmitt M, Dong M, Ferre E, et al. High-throughput identification of autoantibodies that target the human exoproteome. Cell Rep Methods. 2022;2: pubmed publisher

Li K, Wada S, Gosis B, Thorsheim C, Loose P, Arany Z. Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3. PLoS Biol. 2022;20:e3001594 pubmed publisher

Stransky L, Vigeant S, Huang B, West D, Denize T, Walton E, et al. Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway. Proc Natl Acad Sci U S A. 2022;119:e2120403119 pubmed publisher

Ramírez Fernández Á, Aguilar Sopeña Ó, Diez Alonso L, Segura Tudela A, Domínguez Alonso C, Roda Navarro P, et al. Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategies. Oncoimmunology. 2022;11:2054106 pubmed publisher

Gemble S, Wardenaar R, Keuper K, Srivastava N, Nano M, Macé A, et al. Genetic instability from a single S phase after whole-genome duplication. Nature. 2022;604:146-151 pubmed publisher

Wrobel M, Cendrowski J, Szymańska E, Grębowicz Maciukiewicz M, Budick Harmelin N, Macias M, et al. ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway. Life Sci Alliance. 2022;5: pubmed publisher

Zhang Y, Wang Y, Zhao G, Tanner E, Adli M, Matei D. FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway. J Clin Invest. 2022;132: pubmed publisher

Miyake K, Takano N, Kazama H, Kikuchi H, Hiramoto M, Tsukahara K, et al. Ricolinostat enhances adavosertib‑induced mitotic catastrophe in TP53‑mutated head and neck squamous cell carcinoma cells. Int J Oncol. 2022;60: pubmed publisher

Zhou Y, Fu Q, Shi H, Zhou G. CRISPR Guide RNA Library Screens in Human Induced Pluripotent Stem Cells. Methods Mol Biol. 2022;2549:233-257 pubmed publisher

Lu L, Li J, Wei R, Guidi I, Cozzuto L, Ponomarenko J, et al. Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages. Cell Mol Life Sci. 2022;79:209 pubmed publisher

Wang M, Xiong C, Mercurio A. PD-LI promotes rear retraction during persistent cell migration by altering integrin β4 dynamics. J Cell Biol. 2022;221: pubmed publisher

Zhou H, Wang X, Steer C, Song G, Niu J. Efficient silencing of hepatitis B virus S gene through CRISPR-mediated base editing. Hepatol Commun. 2022;6:1652-1663 pubmed publisher

Krysler A, Cromwell C, Tu T, Jovel J, Hubbard B. Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences. Nat Commun. 2022;13:1617 pubmed publisher

Joung J, Kirchgatterer P, Singh A, Cho J, Nety S, Larson R, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13:1606 pubmed publisher

Ramadan A, Mayilsamy K, McGill A, Ghosh A, Giulianotti M, Donow H, et al. Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity. Viruses. 2022;14: pubmed publisher

Sadraeian M, Junior F, Miranda M, Galinskas J, Fernandes R, da Cruz E, et al. Study of Viral Photoinactivation by UV-C Light and Photosensitizer Using a Pseudotyped Model. Pharmaceutics. 2022;14: pubmed publisher

Zhao Y, Huang F, Zou Z, Bi Y, Yang Y, Zhang C, et al. Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72. Cell Mol Immunol. 2022;19:702-714 pubmed publisher

Yoo S, Sinha A, Yang D, Altorki N, Tandon R, Wang W, et al. Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression. Nat Commun. 2022;13:1592 pubmed publisher

Zhao Y, Chen R, Xiao D, Zhang L, Song D, Wen Y, et al. A Comparative Transcriptomic Analysis Reveals That HSP90AB1 Is Involved in the Immune and Inflammatory Responses to Porcine Deltacoronavirus Infection. Int J Mol Sci. 2022;23: pubmed publisher

Lu D, Nagelberg A, Chow J, Chen Y, Michalchuk Q, Somwar R, et al. MET Exon 14 Splice-Site Mutations Preferentially Activate KRAS Signaling to Drive Tumourigenesis. Cancers (Basel). 2022;14: pubmed publisher

Miyazaki Y, Mori N, Akagi Y, Oda T, Kida Y. Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts. Cancers (Basel). 2022;14: pubmed publisher

Warwick T, Schulz M, Gilsbach R, Brandes R, Seuter S. Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor. Nucleic Acids Res. 2022;50:3745-3763 pubmed publisher

Yoo K, Yadav M, Song Q, Atala A, Lu B. Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9. Nucleic Acids Res. 2022;50:3944-3957 pubmed publisher

Wang G, Xiao X, Wang Y, Chu X, Dou Y, Minze L, et al. The RNA helicase DHX15 is a critical regulator of natural killer-cell homeostasis and functions. Cell Mol Immunol. 2022;19:687-701 pubmed publisher

Wongborisuth C, Chumchuen S, Sripichai O, Anurathaphan U, Sathirapongsasuti N, Songdej D, et al. Down-regulation of the transcriptional repressor ZNF802 (JAZF1) reactivates fetal hemoglobin in β0-thalassemia/HbE. Sci Rep. 2022;12:4952 pubmed publisher

Dufour C, Scholtes C, Yan M, Chen Y, Han L, Li T, et al. The mTOR chromatin-bound interactome in prostate cancer. Cell Rep. 2022;38:110534 pubmed publisher

Yao X, Li W, Li L, Li M, Zhao Y, Fang D, et al. YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis. Cell Death Dis. 2022;13:258 pubmed publisher

Fang Z, Sun X, Wang X, Ma J, Palaia T, Rana U, et al. NOGOB receptor deficiency increases cerebrovascular permeability and hemorrhage via impairing histone acetylation-mediated CCM1/2 expression. J Clin Invest. 2022;132: pubmed publisher

Lee Y, Kim J, Jung C, Kim Y, Jung E, Lee S, et al. Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria. Autophagy. 2022;:1-20 pubmed publisher

Guo T, Ma D, Lu T. Sense-and-Respond Payload Delivery Using a Novel Antigen-Inducible Promoter Improves Suboptimal CAR-T Activation. ACS Synth Biol. 2022;11:1440-1453 pubmed publisher

Tsaryk R, Yucel N, Leonard E, Díaz N, Bondareva O, Odenthal Schnittler M, et al. Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Sci Rep. 2022;12:4795 pubmed publisher

Yang M, Gu J, Xu F, Wang Y, Wang H, Zhang B. The protective role of glucocerebrosidase/ceramide in rheumatoid arthritis. Connect Tissue Res. 2022;:1-9 pubmed publisher

Jiang T, Yang J, Yang H, Chen W, Ji K, Xu Y, et al. SLC35B4 Stabilizes c-MYC Protein by O-GlcNAcylation in HCC. Front Pharmacol. 2022;13:851089 pubmed publisher

Balinda H, Sedgwick A, D SOUZA SCHOREY C. Mechanisms underlying melanoma invasion as a consequence of MLK3 loss. Exp Cell Res. 2022;415:113106 pubmed publisher

Valdoz J, Franks N, Cribbs C, Jacobs D, Dodson E, Knight C, et al. Soluble ECM promotes organotypic formation in lung alveolar model. Biomaterials. 2022;283:121464 pubmed publisher

Fan Y, Cheng Z, Mao L, Xu G, Li N, Zhang M, et al. PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles. J Nanobiotechnology. 2022;20:149 pubmed publisher

Vaid x17e iulyt x117 K, Mac xe9 A, Battistella A, Beng W, Schauer K, Coppey M. Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking. elife. 2022;11: pubmed publisher

Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman J, Xue X, et al. A genome-scale screen for synthetic drivers of T cell proliferation. Nature. 2022;603:728-735 pubmed publisher

Huang Y, Zou Y, Jiao Y, Shi P, Nie X, Huang W, et al. Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect. Front Immunol. 2022;13:751296 pubmed publisher

Smith R, Takagishi S, Amici D, Metz K, Gayatri S, Alasady M, et al. HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state. Sci Adv. 2022;8:eabj6526 pubmed publisher

Kummer D, Steinbacher T, Thölmann S, Schwietzer M, Hartmann C, Horenkamp S, et al. A JAM-A-tetraspanin-αvβ5 integrin complex regulates contact inhibition of locomotion. J Cell Biol. 2022;221: pubmed publisher

Sthijns M, Rademakers T, Oosterveer J, Geuens T, van Blitterswijk C, LaPointe V. The response of three-dimensional pancreatic alpha and beta cell co-cultures to oxidative stress. PLoS ONE. 2022;17:e0257578 pubmed publisher

Xiao W, Pinilla Baquero A, Faulkner J, Song X, Prabhakar P, Qiu H, et al. Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep. 2022;12:4352 pubmed publisher

Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, et al. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Res. 2022;50:3323-3347 pubmed publisher

Pallaseni A, Peets E, Koeppel J, Weller J, Vanderstichele T, Ho U, et al. Predicting base editing outcomes using position-specific sequence determinants. Nucleic Acids Res. 2022;50:3551-3564 pubmed publisher

Sun T, Ding C, Zhang Y, Zhang Y, Lin C, Wu J, et al. MESH1 knockdown triggers proliferation arrest through TAZ repression. Cell Death Dis. 2022;13:221 pubmed publisher

Eisen T, Li J, Bartel D. The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation. RNA. 2022;28:808-831 pubmed publisher

Forcina G, Pope L, Murray M, Dong W, Abu Remaileh M, Bertozzi C, et al. Ferroptosis regulation by the NGLY1/NFE2L1 pathway. Proc Natl Acad Sci U S A. 2022;119:e2118646119 pubmed publisher

Sidorova O, Sayed S, Paszkowski Rogacz M, Seifert M, Camgoz A, Roeder I, et al. RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations. Cells. 2022;11: pubmed publisher

Besse A, Kraus M, Mendez Lopez M, Maurits E, Overkleeft H, Driessen C, et al. Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors. Cells. 2022;11: pubmed publisher

Xu H, LaFlamme S. Contribution of Endothelial Laminin-Binding Integrins to Cellular Processes Associated with Angiogenesis. Cells. 2022;11: pubmed publisher

Sadangi S, Milosavljevic K, Castro Pérez E, Lares M, Singh M, Altameemi S, et al. Role of the Skin Microenvironment in Melanomagenesis: Epidermal Keratinocytes and Dermal Fibroblasts Promote BRAF Oncogene-Induced Senescence Escape in Melanocytes. Cancers (Basel). 2022;14: pubmed publisher

V xe1 zquez Naharro A, Bustos Tauler J, Florist xe1 n A, Yuste L, Oltra S, Vinyals A, et al. Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival. Cancers (Basel). 2022;14: pubmed publisher

Chen L, Sutharsan R, Lee J, Cruz E, Asnicar B, Palliyaguru T, et al. Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics. 2022;12:1952-1970 pubmed publisher

Tian S, Liu Y, Appleton E, Wang H, Church G, Dong M. Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms. Cell Rep. 2022;38:110476 pubmed publisher

Florian A, Woodley C, Wang J, Grieb B, Slota M, Guerrazzi K, et al. Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells. NAR Cancer. 2022;4:zcac007 pubmed publisher

Chen W, Gard J, Epshtein Y, Camp S, Garcia J, Jacobson J, et al. Integrin Beta 4E Promotes Endothelial Phenotypic Changes and Attenuates Lung Endothelial Cell Inflammatory Responses. Front Physiol. 2022;13:769325 pubmed publisher

Javaid S, Schaefer A, Goodwin C, Nguyen V, Massey F, Pierobon M, et al. Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma. Mol Cancer Ther. 2022;21:762-774 pubmed publisher

Li Y, Feng R, Yu X, Li L, Liu Y, Zhang R, et al. SLC35E2 promoter mutation as a prognostic marker of esophageal squamous cell carcinoma. Life Sci. 2022;296:120447 pubmed publisher

Omachi K, Kai H, Roberge M, Miner J. NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthrough. iScience. 2022;25:103891 pubmed publisher

North K, Benbarche S, Liu B, Pangallo J, Chen S, Stahl M, et al. Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. Nat Biotechnol. 2022;: pubmed publisher

Kumar R, Rao G. Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization. Arterioscler Thromb Vasc Biol. 2022;42:407-427 pubmed publisher

Cujba A, Alvarez Fallas M, Pedraza Arevalo S, Laddach A, Shepherd M, Hattersley A, et al. An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function. Cell Rep. 2022;38:110425 pubmed publisher

Ramirez N, Lee J, Zheng Y, Li L, Dennis B, Chen D, et al. ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. Nat Commun. 2022;13:1109 pubmed publisher

Schene I, Joore I, Baijens J, Stevelink R, Kok G, Shehata S, et al. Mutation-specific reporter for optimization and enrichment of prime editing. Nat Commun. 2022;13:1028 pubmed publisher

Hossain M, Mawatari S, Fujino T. Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor. Front Cell Dev Biol. 2022;10:828282 pubmed publisher

Mulgaonkar N, Wang H, Mallawarachchi S, Ruzek D, Martina B, Fernando S. In silico and in vitro evaluation of imatinib as an inhibitor for SARS-CoV-2. J Biomol Struct Dyn. 2022;:1-10 pubmed publisher

Turdo A, Gaggianesi M, Di Franco S, Veschi V, D Accardo C, Porcelli G, et al. Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51. Oncogene. 2022;41:2196-2209 pubmed publisher

Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, et al. The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Cell Biosci. 2022;12:20 pubmed publisher

Zhang F, He P, Rodrigues A, Jeske W, Tandon R, Bates J, et al. Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate. Pharmaceuticals (Basel). 2022;15: pubmed publisher

Shinkawa Y, Imami K, Fuseya Y, Sasaki K, Ohmura K, Ishihama Y, et al. ABIN1 is a signal-induced autophagy receptor that attenuates NF-κB activation by recognizing linear ubiquitin chains. FEBS Lett. 2022;596:1147-1164 pubmed publisher

Diao Y, Li Y, Wang Z, Wang S, Li P, Kong B. SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52. Cell Death Dis. 2022;13:179 pubmed publisher

Pushparaj S, Zhu Z, Huang C, More S, Liang Y, Lin K, et al. Regulation of influenza A virus infection by Lnc-PINK1-2:5. J Cell Mol Med. 2022;26:2285-2298 pubmed publisher

Ilina E, Cialini C, Gerloff D, Duarte Garcia Escudero M, Jeanty C, Thézenas M, et al. Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration. iScience. 2022;25:103842 pubmed publisher

Bedsaul J, Shah N, Hutcherson S, Pomerantz J. Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants. iScience. 2022;25:103810 pubmed publisher

Cherbonneau F, Li G, Gokulnath P, Sahu P, Prunevieille A, Kitchen R, et al. TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells. iScience. 2022;25:103806 pubmed publisher

Cai W, Srivastava P, Feng D, Lin Y, Vanderburg C, Xu Y, et al. Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease. Mol Neurodegener. 2022;17:16 pubmed publisher

Kapadia B, Roychowdhury A, Kayastha F, Nanaji N, Gartenhaus R. PARK2 regulates eIF4B-driven lymphomagenesis. Mol Cancer Res. 2022;: pubmed publisher

Shramova E, Chumakov S, Shipunova V, Ryabova A, Telegin G, Kabashin A, et al. Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Light Sci Appl. 2022;11:38 pubmed publisher

D Arcy B, Arrington J, Weisman J, McClellan S, Vandana -, Yang Z, et al. PMS2 variant results in loss of ATPase activity without compromising mismatch repair. Mol Genet Genomic Med. 2022;:e1908 pubmed publisher

Ramírez Torres A, Gil J, Contreras S, Ramírez G, Valencia González H, Salazar Bustamante E, et al. Quantitative Proteomic Analysis of Cervical Cancer Tissues Identifies Proteins Associated With Cancer Progression. Cancer Genomics Proteomics. 2022;19:241-258 pubmed publisher

Luo H, Zhu G, Eshelman M, Fung T, Lai Q, Wang F, et al. HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia. Mol Cell. 2022;82:833-851.e11 pubmed publisher

Miao C, Tsujino T, Takai T, Gui F, Tsutsumi T, Sztupinszki Z, et al. RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. Sci Adv. 2022;8:eabl9794 pubmed publisher

Fan C, Shi X, Zhao K, Wang L, Shi K, Liu Y, et al. Cell migration orchestrates migrasome formation by shaping retraction fibers. J Cell Biol. 2022;221: pubmed publisher

Li H, Wu B, Kanchwala M, Cai J, Wang L, Xing C, et al. YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis. Nat Cell Biol. 2022;24:373-383 pubmed publisher

Song L, Luo J, Wang H, Huang D, Tan Y, Liu Y, et al. Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector. elife. 2022;11: pubmed publisher

Blaha C, Ramakrishnan G, Jeon S, Nogueira V, Rho H, Kang S, et al. A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis. Nat Commun. 2022;13:899 pubmed publisher

Sivakumar S, Qi S, Cheng N, Sathe A, Kanchwala M, Kumar A, et al. TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 2022;38:110395 pubmed publisher

Kim K, Kabra A, Kim D, Xue Y, Huang Y, Hou P, et al. KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer. Sci Adv. 2022;8:eabl4618 pubmed publisher

Magg V, Klein P, Ruggieri A. Monitoring Virus-Induced Stress Granule Dynamics Using Long-Term Live-Cell Imaging. Methods Mol Biol. 2022;2428:325-348 pubmed publisher

Chen R, Liu J, Li S, Li X, Huo Y, Yao Y, et al. Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants. BMC Med. 2022;20:68 pubmed publisher

Wang Y, Xie S, Armendariz D, Hon G. Computational identification of clonal cells in single-cell CRISPR screens. BMC Genomics. 2022;23:135 pubmed publisher

Lin P, Shen G, Guo K, Qin S, Pu Q, Wang Z, et al. Type III CRISPR-based RNA editing for programmable control of SARS-CoV-2 and human coronaviruses. Nucleic Acids Res. 2022;50:e47 pubmed publisher

Urrutia Cabrera D, Hsiang Chi Liou R, Lin J, Shi Y, Liu K, Hung S, et al. Combinatorial Approach of Binary Colloidal Crystals and CRISPR Activation to Improve Induced Pluripotent Stem Cell Differentiation into Neurons. ACS Appl Mater Interfaces. 2022;14:8669-8679 pubmed publisher

Sanchez Rivera F, Diaz B, Kastenhuber E, Schmidt H, Katti A, Kennedy M, et al. Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. Nat Biotechnol. 2022;40:862-873 pubmed publisher

Vidal A, Redmer T. Tracking of Melanoma Cell Plasticity by Transcriptional Reporters. Int J Mol Sci. 2022;23: pubmed publisher

Shembrey C, Smith J, Grandin M, Williams N, Cho H, Mølck C, et al. Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models. Cancers (Basel). 2022;14: pubmed publisher

Scambi I, Peroni D, Nodari A, Merigo F, Benati D, Boschi F, et al. The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age. Eur J Cell Biol. 2022;101:151206 pubmed publisher

Stok J, Oosenbrug T, Ter Haar L, Gravekamp D, Bromley C, Zelenay S, et al. RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency. EMBO J. 2022;41:e109760 pubmed publisher

Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, et al. BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection. Pharmacol Res. 2022;177:106122 pubmed publisher

Li X, Morgan C, Goff L, Doetzlhofer A. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea. Sci Adv. 2022;8:eabj7651 pubmed publisher

Ravi N, Wienert B, Wyman S, Bell H, George A, Mahalingam G, et al. Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. elife. 2022;11: pubmed publisher

Shalaby N, Kelly J, Martinez F, Fox M, Qi Q, Thiessen J, et al. A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking. Mol Imaging Biol. 2022;24:341-351 pubmed publisher

Su R, Dong L, Li Y, Gao M, He P, Liu W, et al. METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis. Nat Cell Biol. 2022;24:205-216 pubmed publisher

Huang D, Wang Y, Thompson J, Yin T, Alexander P, Qin D, et al. Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression. Nat Cell Biol. 2022;24:230-241 pubmed publisher

Zhu D, Xia J, Liu C, Fang C. Numb/Notch/PLK1 signaling pathway mediated hyperglycemic memory in pancreatic cancer cell radioresistance and the therapeutic effects of metformin. Cell Signal. 2022;93:110268 pubmed publisher

Zhang X, Hu Y, Pan Y, Xiong Y, Zhang Y, Han M, et al. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6. Oncogene. 2022;41:1821-1834 pubmed publisher

Johnson F, Ferrarone J, Liu A, Brandstädter C, Munuganti R, Farnsworth D, et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 2022;38:110343 pubmed publisher

Benbarche S, Lopez C, Salataj E, Aid Z, Thirant C, Laiguillon M, et al. Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia. Sci Adv. 2022;8:eabg9455 pubmed publisher

Simon B, Lou H, Huet Calderwood C, Shi G, Boggon T, Turk B, et al. Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Nat Commun. 2022;13:749 pubmed publisher

Yang X, Wu G, Zhang Q, Chen X, Li J, Han Q, et al. ACSM3 suppresses the pathogenesis of high-grade serous ovarian carcinoma via promoting AMPK activity. Cell Oncol (Dordr). 2022;45:151-161 pubmed publisher

Falcomatà C, Bärthel S, Widholz S, Schneeweis C, Montero J, Toska A, et al. Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. 2022;3:318-336 pubmed publisher

Aoyama S, Yasuda S, Li H, Watanabe D, Umezawa Y, Okada K, et al. A novel chimeric antigen receptor (CAR) system using an exogenous protease, in which activation of T cells is controlled by expression patterns of cell‑surface proteins on target cells. Int J Mol Med. 2022;49: pubmed publisher

Yan Y, Zhou B, Qian C, Vasquez A, Kamra M, Chatterjee A, et al. Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis. Nat Commun. 2022;13:669 pubmed publisher

Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, et al. Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML. Transl Oncol. 2022;18:101354 pubmed publisher

Schmidt R, Steinhart Z, Layeghi M, Freimer J, Bueno R, Nguyen V, et al. CRISPR activation and interference screens decode stimulation responses in primary human T cells. Science. 2022;375:eabj4008 pubmed publisher

Abdo A, Rintisch C, Gabriel C, Kramer A. Mutational scanning identified amino acids of the CLOCK exon 19-domain essential for circadian rhythms. Acta Physiol (Oxf). 2022;234:e13794 pubmed publisher

Nguyen H, Wu T, Needs D, Zhang H, Perelli R, DeLuca S, et al. Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. Nat Commun. 2022;13:620 pubmed publisher

Luo J, Zou H, Guo Y, Huang K, Ngan E, Li P. BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids. Cell Death Discov. 2022;8:47 pubmed publisher

Song C, Wang L, Li Q, Liao B, Qiao W, Li Q, et al. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem Cell Res Ther. 2022;13:48 pubmed publisher

Osokine I, Siewiera J, Rideaux D, Ma S, Tsukui T, Erlebacher A. Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface. Cell Rep. 2022;38:110329 pubmed publisher

Chan H, Leong C, Lim C, Koh R. Roles of receptor-interacting protein kinase 1 in SH-SY5Y cells with beta amyloid-induced neurotoxicity. J Cell Mol Med. 2022;26:1434-1444 pubmed publisher

Kamatani T, Otsuka R, Murata T, Wada H, Takahashi T, Mori A, et al. Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model. Inflamm Regen. 2022;42:4 pubmed publisher

Krenning L, Sonneveld S, Tanenbaum M. Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition. elife. 2022;11: pubmed publisher

Facchinello N, Astone M, Audano M, Oberkersch R, Spizzotin M, Calura E, et al. Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nat Metab. 2022;4:123-140 pubmed publisher

Zou H, Luo J, Guo Y, Liu Y, Wang Y, Deng L, et al. RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7. Oncogene. 2022;41:1657-1672 pubmed publisher

Siddaway R, Milos S, Vadivel A, Dobson T, Swaminathan J, Ryall S, et al. Splicing is an alternate oncogenic pathway activation mechanism in glioma. Nat Commun. 2022;13:588 pubmed publisher

Gargini R, Segura Collar B, Garranzo Asensio M, Hortigüela R, Iglesias Hernández P, Lobato Alonso D, et al. IDP-410: a Novel Therapeutic Peptide that Alters N-MYC Stability and Reduces Angiogenesis and Tumor Progression in Glioblastomas. Neurotherapeutics. 2022;19:408-420 pubmed publisher

Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, et al. m6A modifications regulate intestinal immunity and rotavirus infection. elife. 2022;11: pubmed publisher

Li Y, Shen Y, Xie M, Wang B, Wang T, Zeng J, et al. LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1. Signal Transduct Target Ther. 2022;7:30 pubmed publisher

Ouwens D, Hewera M, Li G, Di W, Muhammad S, Hänggi D, et al. Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells. Front Biosci (Landmark Ed). 2022;27:35 pubmed publisher

Shahi A, Kahle J, Hopkins C, Diakonova M. The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification. PLoS ONE. 2022;17:e0261098 pubmed publisher

Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, et al. Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists. Mol Cancer Ther. 2022;21:594-606 pubmed publisher

Grodzki M, Bluhm A, Schaefer M, Tagmount A, Russo M, Sobh A, et al. Genome-scale CRISPR screens identify host factors that promote human coronavirus infection. Genome Med. 2022;14:10 pubmed publisher

Tegowski M, Flamand M, Meyer K. scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells. Mol Cell. 2022;82:868-878.e10 pubmed publisher

Cheng W, Liu F, Ren Z, Chen W, Chen Y, Liu T, et al. Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens. Nat Commun. 2022;13:478 pubmed publisher

Fu R, He W, Dou J, Villarreal O, Bedford E, Wang H, et al. Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Nat Commun. 2022;13:474 pubmed publisher

Yoo S, Mittelstein D, Hurt R, Lacroix J, Shapiro M. Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification. Nat Commun. 2022;13:493 pubmed publisher

Xie J, Ma G, Zhou L, He L, Zhang Z, Tan P, et al. Identification of a STIM1 Splicing Variant that Promotes Glioblastoma Growth. Adv Sci (Weinh). 2022;9:e2103940 pubmed publisher

Tarangelo A, Rodencal J, Kim J, Magtanong L, Long J, Dixon S. Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity. Life Sci Alliance. 2022;5: pubmed publisher

Geis F, Sabo Y, Chen X, Li Y, Lu C, Goff S. CHAF1A/B mediate silencing of unintegrated HIV-1 DNAs early in infection. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher

Gao Y, Yin Z, Qi Y, Peng H, Ma W, Wang R, et al. Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p. Cancer Cell Int. 2022;22:35 pubmed publisher

Thölmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, et al. JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells. Cell Mol Life Sci. 2022;79:88 pubmed publisher

Ding X, Chen J, Ma H, Liang Y, Wang Y, Zhang H, et al. KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation. Life Sci. 2022;293:120320 pubmed publisher

Duguay B, Herod A, Pringle E, Monro S, Hetu M, Cameron C, et al. Photodynamic Inactivation of Human Coronaviruses. Viruses. 2022;14: pubmed publisher

Zhang T, Wang Y, Yu H, Zhang T, Guo L, Xu J, et al. PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40. Cell Death Dis. 2022;13:68 pubmed publisher

Walther J, Wilbie D, Tissingh V, xd6 ktem M, van der Veen H, Lou B, et al. Impact of Formulation Conditions on Lipid Nanoparticle Characteristics and Functional Delivery of CRISPR RNP for Gene Knock-Out and Correction. Pharmaceutics. 2022;14: pubmed publisher

Remy J, Linder B, Weirauch U, Day B, Stringer B, Herold Mende C, et al. STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Cancers (Basel). 2022;14: pubmed publisher

Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, et al. CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Cancers (Basel). 2022;14: pubmed publisher

Clees A, Stolp V, Häupl B, Fuhrmann D, Wempe F, Seibert M, et al. Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. Cells. 2022;11: pubmed publisher

Maia N, Potelle S, Yildirim H, Duvet S, Akula S, Schulz C, et al. Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder. Am J Hum Genet. 2022;109:345-360 pubmed publisher

Katrekar D, Xiang Y, Palmer N, Saha A, Meluzzi D, Mali P. Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity. elife. 2022;11: pubmed publisher

Guo X, Elledge S. V-CARMA: A tool for the detection and modification of antigen-specific T cells. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher

Morgens D, Nandakumar D, Didychuk A, Yang K, Glaunsinger B. A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains. PLoS Pathog. 2022;18:e1010236 pubmed publisher

Rufino Ramos D, Lule S, Mahjoum S, Ughetto S, Cristopher Bragg D, Pereira de Almeida L, et al. Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo. Biomaterials. 2022;281:121366 pubmed publisher

Sun C, Wei J, Long Z, Zhao W, Huangfu Q, Xie Q, et al. Spindle pole body component 24 homolog potentiates tumor progression via regulation of SRY-box transcription factor 2 in clear cell renal cell carcinoma. FASEB J. 2022;36:e22086 pubmed publisher

Mudd P, Minervina A, Pogorelyy M, Turner J, Kim W, Kalaidina E, et al. SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans. Cell. 2022;185:603-613.e15 pubmed publisher

Abu Libdeh B, Jhujh S, Dhar S, Sommers J, Datta A, Longo G, et al. RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest. 2022;132: pubmed publisher

Machino H, Kaneko S, Komatsu M, Ikawa N, Asada K, Nakato R, et al. The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma. Commun Biol. 2022;5:39 pubmed publisher

Ratanabunyong S, Seetaha S, Hannongbua S, Yanaka S, Yagi Utsumi M, Kato K, et al. Biophysical Characterization of Novel DNA Aptamers against K103N/Y181C Double Mutant HIV-1 Reverse Transcriptase. Molecules. 2022;27: pubmed publisher

Aass K, Mjelle R, Kastnes M, Tryggestad S, van den Brink L, Aass Roseth I, et al. Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells. iScience. 2022;25:103605 pubmed publisher

Li P, Li S, Gao S, Dong D. A one-step platform for screening high-efficient and minimal off-target CRISPR/Cas13 crRNAs to eradicate SARS-CoV-2 virus for treatment of COVID-19 patients. Med Hypotheses. 2022;159:110754 pubmed publisher

Danielsson B, Peters H, Bathula K, Spear L, Noll N, Dahl K, et al. Progerin-Expressing Endothelial Cells are Unable to Adapt to Shear Stress. Biophys J. 2022;: pubmed publisher

Koritala B, Porter K, Sarkar S, Gaddameedhi S. Circadian disruption and cisplatin chronotherapy for mammary carcinoma. Toxicol Appl Pharmacol. 2022;436:115863 pubmed publisher

Hwang J, Wang H, Lu Y, Ikawa M, Chung J. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane. Cell Rep. 2022;:110226 pubmed publisher

Lee G, Huang S, Aw W, Rathod M, Cho C, Ligler F, et al. Multilayer microfluidic platform for the study of luminal, transmural, and interstitial flow. Biofabrication. 2022;14: pubmed publisher

Wang B, Li J, Liu L, Song G. Insulin sensitivity in the aged heart is improved by down-regulation of KAT7 in vivo and in vitro. Cell Cycle. 2022;:1-13 pubmed publisher

Pan C, Cai Q, Li X, Li L, Yang L, Chen Y, et al. Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1. Cell Mol Immunol. 2022;: pubmed publisher

Katakam S, Anand S, Martin P, Riggi N, Stamenkovic I. Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis. Life Sci Alliance. 2022;5: pubmed publisher

Kim H, Cho J, Kim E, Kim J, Yang J, Kim K, et al. Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection. J Extracell Vesicles. 2022;11:e12179 pubmed publisher

Zheng A, Dubuis G, Georgieva M, Mendes Ferreira C, Serulla M, Del Carmen Conde Rubio M, et al. HDLs extract lipophilic drugs from cells. J Cell Sci. 2022;135: pubmed publisher

Zeng J, Xie X, Feng X, Xu L, Han J, Yu D, et al. Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice. EBioMedicine. 2022;75:103803 pubmed publisher

van Neerven S, Ramadan R, van Driel M, Huels D, Vermeulen L. Intestinal organoid co-culture protocol to study cell competition in vitro. STAR Protoc. 2022;3:101050 pubmed publisher

Wang P, Gong S, Liao B, Pan J, Wang J, Zou D, et al. HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions. J Cancer. 2022;13:1-14 pubmed publisher

Zheng D, Wang X, Zhang Z, Li E, Yeung C, Borkar R, et al. Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes. Int J Biol Sci. 2022;18:426-440 pubmed publisher

Engedal N, Sønstevold T, Beese C, Selladurai S, Melcher T, Simensen J, et al. Measuring Autophagic Cargo Flux with Keima-Based Probes. Methods Mol Biol. 2022;2445:99-115 pubmed publisher

Zhai J, Liu Z, Wang H, Huang G, Man L. GPNMB overexpression is associated with extensive bone metastasis and poor prognosis in renal cell carcinoma. Oncol Lett. 2022;23:36 pubmed publisher

Kato H, Tateishi K, Fujiwara H, Nakatsuka T, Yamamoto K, Kudo Y, et al. MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages. Gastroenterology. 2022;162:1272-1287.e16 pubmed publisher

Medhi R, Price J, Furlan G, Gorges B, Sapetschnig A, Miska E. RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type. RNA. 2022;28:353-370 pubmed publisher

Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, et al. Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. Cancer Sci. 2022;113:971-985 pubmed publisher

Matvey D, Ng T, Miller M. Confocal Imaging of Single-Cell Signaling in Orthotopic Models of Ovarian Cancer. Methods Mol Biol. 2022;2424:295-315 pubmed publisher

Battagliotti J, Fontana D, Etcheverrigaray M, Kratje R, Prieto C. Development, Production, and Characterization of Hepatitis B Subviral Envelope Particles as a Third-Generation Vaccine. Methods Mol Biol. 2022;2410:273-287 pubmed publisher

Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, et al. Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules. Int J Oncol. 2022;60: pubmed publisher

Voeltzel T, Fossard G, Degaud M, Geistlich K, Gadot N, Jeanpierre S, et al. A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes. Biomater Sci. 2022;10:485-498 pubmed publisher

Pivniouk V, Pivniouk O, Devries A, Uhrlaub J, Michael A, Pivniouk D, et al. The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. J Allergy Clin Immunol. 2022;149:923-933.e6 pubmed publisher

Hu M, Lei X, Larson J, McAlonis M, Ford K, McDonald D, et al. Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures. Biomaterials. 2022;280:121276 pubmed publisher

Lin Y, Huang C, Gao H, Li X, Lin Q, Zhou S, et al. AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. J Cell Sci. 2022;135: pubmed publisher

Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, et al. ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Oncol Rep. 2022;47: pubmed publisher

Villa A, Brunialti E, Dellavedova J, Meda C, Rebecchi M, Conti M, et al. DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic. Pharmacol Res. 2022;175:105982 pubmed publisher

Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Xu Z, et al. HSP27 protects against ferroptosis of glioblastoma cells. Hum Cell. 2022;35:238-249 pubmed publisher

Heumüller A, Jones A, Mourão A, Klangwart M, Shi C, Wittig I, et al. Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses. Circ Res. 2022;130:67-79 pubmed publisher

Miyamoto S, Nagano Y, Miyazaki M, Nagamura Y, Sasaki K, Kawamura T, et al. Integrin α5 mediates cancer cell-fibroblast adhesion and peritoneal dissemination of diffuse-type gastric carcinoma. Cancer Lett. 2022;526:335-345 pubmed publisher

Misek S, Newbury P, Chekalin E, Paithankar S, Doseff A, Chen B, et al. Ibrutinib Blocks YAP1 Activation and Reverses BRAF Inhibitor Resistance in Melanoma Cells. Mol Pharmacol. 2022;101:1-12 pubmed publisher

Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, et al. Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2022;21:89-99 pubmed publisher

Kwanten B, Neggers J, Daelemans D. Target Identification of Small Molecules Using Large-Scale CRISPR-Cas Mutagenesis Scanning of Essential Genes. Methods Mol Biol. 2022;2377:43-67 pubmed publisher

Jiang L, Liang J, Huang W, Ma J, Park K, Wu Z, et al. CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Mol Ther. 2022;30:54-74 pubmed publisher

Yeung S, Zhou Y, Zou W, Chan W, Ching Y. TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Cancer Lett. 2022;524:70-81 pubmed publisher

Volkwein W, Pavlovic M, Anton M, Haase M, Stellberger T, Jarrar A, et al. Detection and differentiation of murine leukemia virus (MLV) and murine stem cell virus (MSCV) and therefrom derived nucleic acids. J Virol Methods. 2022;299:114316 pubmed publisher

Zhu W, Cheng Y, Wang Z, Ji L, Ma J, Yan Y, et al. The identification of a shorter cyclic GMP-AMP synthase gene from chickens and bioinformatics analysis of its potential signaling in IFN regulation. Dev Comp Immunol. 2022;127:104266 pubmed publisher

Gao Y, Xiong J, Chu Q, Ji W. PDZD8-mediated lipid transfer at contacts between the ER and late endosomes/lysosomes is required for neurite outgrowth. J Cell Sci. 2022;135: pubmed publisher

López Muneta L, Linares J, Casis O, Martínez Ibáñez L, González Miqueo A, Bezunartea J, et al. Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts. Front Cell Dev Biol. 2021;9:797927 pubmed publisher

Fred S, Kuivanen S, Uğurlu H, Casarotto P, Levanov L, Saksela K, et al. Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro. Front Pharmacol. 2021;12:755600 pubmed publisher

Zhang Y, Zhang X, Zhang H, Song P, Pan W, Xu P, et al. Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell Polarization. Front Immunol. 2021;12:811164 pubmed publisher

Busby T, Chen Y, Godfrey T, Rehan M, Wildman B, Smith C, et al. Baf45a Mediated Chromatin Remodeling Promotes Transcriptional Activation for Osteogenesis and Odontogenesis. Front Endocrinol (Lausanne). 2021;12:763392 pubmed publisher

Yamaguchi S, Zhang D, Katayama A, Kurooka N, Sugawara R, Albuayjan H, et al. Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4. Front Endocrinol (Lausanne). 2021;12:750261 pubmed publisher

Correia M, Stojanovic A, Wels W, Cerwenka A. Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity. Oncoimmunology. 2021;10:1973783 pubmed publisher

Farahani P, Lemke S, Dine E, Uribe G, Toettcher J, Nelson C. Substratum stiffness regulates Erk signaling dynamics through receptor-level control. Cell Rep. 2021;37:110181 pubmed publisher

Cha Y, Kim T, Jeon J, Jang Y, Kim P, Lopes C, et al. SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes. Cell Rep. 2021;37:110155 pubmed publisher

Cona B, Hayashi T, Yamada A, Shimizu N, Yokota N, Nakato R, et al. The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR-Cas9 screen. FEBS Open Bio. 2021;: pubmed publisher

Sigurdardottir A, Jonasdottir A, Asbjarnarson A, Helgudottir H, Gudjonsson T, Traustadóttir G. Peroxidasin Enhances Basal Phenotype and Inhibits Branching Morphogenesis in Breast Epithelial Progenitor Cell Line D492. J Mammary Gland Biol Neoplasia. 2021;: pubmed publisher

Bow A, Masi T, Dhar M. Etched 3D-Printed Polycaprolactone Constructs Functionalized with Reduced Graphene Oxide for Enhanced Attachment of Dental Pulp-Derived Stem Cells. Pharmaceutics. 2021;13: pubmed publisher

Gaeta I, Meenderink L, Tyska M. A protocol for imaging microvilli biogenesis on the surface of cultured porcine kidney epithelial cell monolayers. STAR Protoc. 2021;2:100998 pubmed publisher

Peralta Garcia A, Torrens Fontanals M, Stępniewski T, Grau Expósito J, Perea D, Ayinampudi V, et al. Entrectinib-A SARS-CoV-2 Inhibitor in Human Lung Tissue (HLT) Cells. Int J Mol Sci. 2021;22: pubmed publisher

Sønstevold T, Engedal N, Torgersen M. Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy. Cells. 2021;10: pubmed publisher

Song Y, He P, Rodrigues A, Datta P, Tandon R, Bates J, et al. Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum. Mar Drugs. 2021;19: pubmed publisher

Benman W, Berlew E, Deng H, Parker C, Kuznetsov I, Lim B, et al. Temperature-responsive optogenetic probes of cell signaling. Nat Chem Biol. 2021;: pubmed publisher

Chen W, Ding Y, Liu D, Lu Z, Wang Y, Yuan Y. Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis. PLoS Pathog. 2021;17:e1009600 pubmed publisher

Taniguchi S, Tanaka Y, Elhance A, Oshimori N. A mechanistic basis for the malignant progression of salivary gland tumors. iScience. 2021;24:103508 pubmed publisher

Pesch A, Hirsh N, Michmerhuizen A, Jungles K, Wilder Romans K, Chandler B, et al. RB expression confers sensitivity to CDK4/6 inhibitor-mediated radiosensitization across breast cancer subtypes. JCI Insight. 2021;: pubmed publisher

Clark L, Clark S, Lin C, Liu J, Coscia A, Nabel K, et al. VLDLR and ApoER2 are receptors for multiple alphaviruses. Nature. 2021;: pubmed publisher

Vamva E, Griffiths A, Vink C, Lever A, Kenyon J. A novel role for gag as a cis-acting element regulating RNA structure, dimerization and packaging in HIV-1 lentiviral vectors. Nucleic Acids Res. 2021;: pubmed publisher

Hyun J, Lee M, Rehman J, Pajcini K, Malik A. Notch1 promotes revascularization through modulation of downstream vascular patterning signaling. J Physiol. 2021;: pubmed publisher

Lee B, Hogg E, Below C, Kononov A, Blanco Gómez A, Heider F, et al. Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. Nat Commun. 2021;12:7336 pubmed publisher

Swamy H, Glading A. Contribution of protein-protein interactions to the endothelial barrier-stabilizing function of KRIT1. J Cell Sci. 2021;: pubmed publisher

Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, et al. Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Nat Commun. 2021;12:7322 pubmed publisher

Scheidmann M, Castro Giner F, Strittmatter K, Krol I, Paasinen Sohns A, Scherrer R, et al. An in vivo CRISPR screen identifies stepwise genetic dependencies of metastatic progression. Cancer Res. 2021;: pubmed publisher

Delgado R, Allen D, Keefe M, Mancia Leon W, Ziffra R, Crouch E, et al. Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature. 2021;: pubmed publisher

Wu B, Rice L, Shrimpton J, Lawless D, Walker K, Carter C, et al. Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder. elife. 2021;10: pubmed publisher

Güney Esken G, Aerts Kaya F. Generation and Hematopoietic Differentiation of Mesenchymal Stromal/Stem Cell-Derived Induced Pluripotent Stem Cell Lines for Disease Modeling of Hematopoietic and Immunological Diseases. Methods Mol Biol. 2021;: pubmed publisher

Ding L, Sun W, Balaz M, He A, Klug M, Wieland S, et al. Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis. Nat Metab. 2021;3:1648-1661 pubmed publisher

Amin R, Shukla A, Zhu J, Kim S, Wang P, Tian S, et al. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. Nat Commun. 2021;12:7216 pubmed publisher