This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
GFP-p53
catalog :
12091
citations: 33
Reference
Legartov xe1 S, Fagherazzi P, Goswami P, Brazda V, Lochmanov xe1 G, Koutn xe1 I, et al. Irradiation potentiates p53 phosphorylation and p53 binding to the promoter and coding region of the TP53 gene. Biochimie. 2022;: pubmed publisher
Liu Y, Wang X, Zhu W, Sui Z, Wei X, Zhang Y, et al. TRPML1-induced autophagy inhibition triggers mitochondrial mediated apoptosis. Cancer Lett. 2022;541:215752 pubmed publisher
Galhuber M, Michenthaler H, Heininger C, Reinisch I, Nössing C, Krstić J, et al. Complementary omics strategies to dissect p53 signaling networks under nutrient stress. Cell Mol Life Sci. 2022;79:326 pubmed publisher
Wang Y, Ho T, Hariharan A, Goh H, Wong Y, Verkaik N, et al. Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity. Proc Natl Acad Sci U S A. 2022;119:e2113233119 pubmed publisher
Xing Y, Wei X, Liu Y, Wang M, Sui Z, Wang X, et al. Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. Autophagy. 2021;:1-23 pubmed publisher
He H, Lin X, Wu D, Wang J, Guo J, Green D, et al. Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells. Cell Rep Phys Sci. 2020;1: pubmed publisher
Mitra S, Veppil Muralidharan S, Di Marco M, Juvvuna P, Thankaswamy Kosalai S, Reischl S, et al. Subcellular distribution of p53 by the p53-responsive lncRNA NBAT1 determines chemotherapeutic response in neuroblastoma. Cancer Res. 2020;: pubmed publisher
Anderson C, Routes T, Eckhardt L, Delisle B, January C, Kamp T. A rapid solubility assay of protein domain misfolding for pathogenicity assessment of rare DNA sequence variants. Genet Med. 2020;: pubmed publisher
Huber S, Bär A, Epp S, Schmuckli Maurer J, Eberhard N, Humbel B, et al. Recruitment of Host Nuclear Pore Components to the Vicinity of Theileria Schizonts. mSphere. 2020;5: pubmed publisher
Tyagi M, Bauri A, Chattopadhyay S, Patro B. Thiol antioxidants sensitize malabaricone C induced cancer cell death via reprogramming redox sensitive p53 and NF-κB proteins in vitro and in vivo. Free Radic Biol Med. 2020;148:182-199 pubmed publisher
Fifield B, Qemo I, Kirou E, Cardiff R, Porter L. The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis. Breast Cancer Res. 2019;21:140 pubmed publisher
Dabiri Y, Abu El Maaty M, Chan H, Wölker J, Ott I, Wolfl S, et al. p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells. Front Oncol. 2019;9:438 pubmed publisher
Rinaldi L, Folliero V, Palomba L, Zannella C, Isticato R, Di Francia R, et al. Sonoporation by microbubbles as gene therapy approach against liver cancer. Oncotarget. 2018;9:32182-32190 pubmed publisher
Chen B, Wang J, Wang J, Wang H, Gu X, Tang L, et al. A regulatory circuitry comprising TP53, miR-29 family, and SETDB1 in non-small cell lung cancer. Biosci Rep. 2018;38: pubmed publisher
Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Barberi E, et al. MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. Oncotarget. 2018;9:20323-20338 pubmed publisher
Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed publisher
Weecharangsan W, Opanasopit P, Niyomtham N, Yingyongnarongkul B, Kewsuwan P, Lee R. Synergistic Inhibition of Human Carcinoma Cell Growth via Co-Delivery of p53 Plasmid DNA and bcl-2 Antisense Oligodeoxyribonucleotide by Cholic Acid-modified Polyethylenimine. Anticancer Res. 2017;37:6335-6340 pubmed
Gabrielsen M, Buetow L, Nakasone M, Ahmed S, Sibbet G, Smith B, et al. A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Mol Cell. 2017;68:456-470.e10 pubmed publisher
Tran L, Kichenadasse G, Butler L, Centenera M, Morel K, Ormsby R, et al. The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. Mol Cancer Ther. 2017;16:2689-2700 pubmed publisher
Ghosh S, Salot S, Sengupta S, Navalkar A, Ghosh D, Jacob R, et al. p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis. Cell Death Differ. 2017;24:1784-1798 pubmed publisher
Nguyen D, Richter D, Michel G, Mitschka S, Kolanus W, Cuevas E, et al. The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation. Cell Death Differ. 2017;24:1063-1078 pubmed publisher
Omar H, Tolba M, Hung J, Al Tel T. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKC?/p53. Front Pharmacol. 2016;7:463 pubmed
Ni T, Li X, Lu N, An T, Liu Z, Fu R, et al. Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer. Nat Cell Biol. 2016;18:1221-1232 pubmed publisher
Hussain T, Schneider M, Summer B, Strieth S. Pre-operative in vitro fibroblast coating of porous polyethylene compound grafts - Cell survival in vivo and effects on biocompatibility. Biomed Mater Eng. 2016;27:237-49 pubmed publisher
Fern ndez Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
Bechill J, Zhong R, Zhang C, Solomaha E, Spiotto M. A High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53. PLoS ONE. 2016;11:e0154125 pubmed publisher
Stixová L, Sehnalová P, Legartová S, Suchánková J, Hrušková T, Kozubek S, et al. HP1β-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs. Epigenetics Chromatin. 2014;7:39 pubmed publisher
Martino Echarri E, Henderson B, Brocardo M. Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy. Oncotarget. 2014;5:9889-900 pubmed
Chen B, Suen Y, Gu S, Li L, Chan W. A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. Sci Rep. 2014;4:6413 pubmed publisher
Herce H, Deng W, Helma J, Leonhardt H, Cardoso M. Visualization and targeted disruption of protein interactions in living cells. Nat Commun. 2013;4:2660 pubmed publisher
Liao W, Liaw C, Huang Y, Han H, Hsu H, Hwang S, et al. Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG. Evid Based Complement Alternat Med. 2013;2013:170261 pubmed publisher
Stixova L, Bartova E, Matula P, Danek O, Legartova S, Kozubek S. Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin. Epigenetics Chromatin. 2011;4:5 pubmed publisher
Boyd S, Tsai K, Jacks T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat Cell Biol. 2000;2:563-8 pubmed
product information
Catalog Number :
12091
Product Name :
GFP-p53
article :
doi10.1038/35023500
id723
pubmed_id10980695
bacterial resistance :
Kanamycin
cloning :
backbonepEGFP-N1
backbone_mutation
backbone_originClontech
backbone_size4730
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
The full cDNA sequence of the wild-type human p53 gene was amplified by PCR using a set of primers that introduced terminal PstI and BamHI sites. The amplified product was cloned into pEGFP/N1.
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3BamHI
cloning_site_5PstI
promoter
sequencing_primer_3EGFP-N
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBCC7, BMFS5, LFS1, P53, TRP53
geneTP53
id7157
genbank_ids
AAD28628.1
mutation72R variant of p53
namep53
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagGFP
resistance markers :
225
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA