This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pLX307 MCL1
catalog :
117726
citations: 5
Reference
Satta T, Li L, Chalasani S, Hu X, Nkwocha J, Sharma K, et al. Dual mTORC1/2 Inhibition Synergistically Enhances AML Cell Death in Combination with the BCL2 Antagonist Venetoclax. Clin Cancer Res. 2023;29:1332-1343 pubmed publisher
Kohli J, Ge C, Fitsiou E, Doepner M, Brandenburg S, Faller W, et al. Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression. Nat Commun. 2022;13:7923 pubmed publisher
Orzalli M, Prochera A, Payne L, Smith A, Garlick J, Kagan J. Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells. Immunity. 2021;54:1447-1462.e5 pubmed publisher
Zhang H, Nakauchi Y, Köhnke T, Stafford M, Bottomly D, Thomas R, et al. Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia. Nat Cancer. 2020;1:826-839 pubmed publisher
Hong A, Guerriero J, Doshi M, Kynnap B, Kim W, Schinzel A, et al. MCL1 and DEDD Promote Urothelial Carcinoma Progression. Mol Cancer Res. 2019;17:1294-1304 pubmed publisher
product information
Catalog Number :
117726
Product Name :
pLX307 MCL1
article :
doi10.1158/1541-7786.MCR-18-0963
id28195895
pubmed_id30777879
bacterial resistance :
Ampicillin
cloning :
backbonepLX307
backbone_mutation
backbone_originBroad Institute
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Lentiviral
growth strain :
Open reading frame vector encoding MCL1
origin :
30
pi :
alt_names
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoterEF1a
sequencing_primer_3WPRE-R
sequencing_primer_5EF1a-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
geneMCL1
id4170
genbank_ids
mutation
nameMCL1L
shRNA_sequence
size1049
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagV5
resistance markers :
184
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA