This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCMV5B-TGFbeta receptor II wt
catalog :
11766
citations: 8
Reference
Melendez J, Sieiro D, Salgado D, Morin V, Dejardin M, Zhou C, et al. TGFβ signalling acts as a molecular brake of myoblast fusion. Nat Commun. 2021;12:749 pubmed publisher
Nyati S, Gregg B, Xu J, Young G, Kimmel L, Nyati M, et al. TGFBR2 mediated phosphorylation of BUB1 at Ser-318 is required for transforming growth factor-β signaling. Neoplasia. 2020;22:163-178 pubmed publisher
Park J, Kim Y, Park E, Lee S, Kim H, Kim A, et al. Effects of metformin and phenformin on apoptosis and epithelial-mesenchymal transition in chemoresistant rectal cancer. Cancer Sci. 2019;110:2834-2845 pubmed publisher
Inoue Mochita M, Inoue T, Kojima S, Futakuchi A, Fujimoto T, Sato Ohira S, et al. Interleukin-6-mediated trans-signaling inhibits transforming growth factor-β signaling in trabecular meshwork cells. J Biol Chem. 2018;293:10975-10984 pubmed publisher
Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, et al. TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Sci Signal. 2017;10: pubmed publisher
Kim G, Lim H, Park H. Binding of coronin 1B to T?RI negatively regulates the TGF?1 signaling pathway. Biochem Biophys Res Commun. 2017;490:574-579 pubmed publisher
Park B, Freeman Z, Ghasemzadeh A, Chattergoon M, Rutebemberwa A, Steigner J, et al. TGF?1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer. Cancer Discov. 2016;6:1366-1381 pubmed
Wrana J, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M, et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell. 1992;71:1003-14 pubmed
product information
Catalog Number :
11766
Product Name :
pCMV5B-TGFbeta receptor II wt
article :
doi10.1016/0092-8674(92)90395-S
id656
pubmed_id1333888
bacterial resistance :
Ampicillin
cloning :
backbonepCMV5B
backbone_mutation
backbone_origin
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3BamHI
cloning_site_5KpnI
promoter
sequencing_primer_3hGH-pA-R
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TBR-ii, TBRII, TGFR-2, TGFbeta-RII, tbetaR-II
geneTGFBR2
id7048
genbank_ids
NM_003242
mutation
nameTGFbeta receptor II
shRNA_sequence
size1800
species
9606
Homo sapiens
tags
locationC terminal on insert
tagHA
plasmid copy :
This plasmid was constructed at the Massague lab at MSKCC. Please acknowledge both the Wrana and Massague labs in your publication.
resistance markers :
313
589
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA