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product summary
company name :
Addgene
product type :
cDNA
product name :
hCathepsin B
catalog :
11249
citations: 8
Reference
Pastorio C, Noettger S, Nchioua R, Zech F, Sparrer K, Kirchhoff F. Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization. iScience. 2023;26:108299 pubmed publisher
Huang P, Cao Q, Xu M, Dong X. Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D. Cells. 2022;11: pubmed publisher
Kim M, Jeong H, Krainc D. Lysosomal ceramides regulate Cathepsin B-mediated processing of saposin C and glucocerebrosidase activity. Hum Mol Genet. 2022;: pubmed publisher
Han L, Xu D, Xi Z, Wu M, Nik Nabil W, Zhang J, et al. The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro. Front Pharmacol. 2020;11:564833 pubmed publisher
Mizunoe Y, Kobayashi M, Hoshino S, Tagawa R, Itagawa R, Hoshino A, et al. Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes. Sci Rep. 2020;10:634 pubmed publisher
Luong B, Schwenk R, Bräutigam J, Muller R, Menche D, Bischoff I, et al. The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen. PLoS ONE. 2018;13:e0203053 pubmed publisher
Mizunoe Y, Sudo Y, Okita N, Hiraoka H, Mikami K, Narahara T, et al. Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. Autophagy. 2017;13:642-653 pubmed publisher
Huang I, Bosch B, Li F, Li W, Lee K, Ghiran S, et al. SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem. 2006;281:3198-203 pubmed
product information
Catalog Number :
11249
Product Name :
hCathepsin B
article :
doi10.1074/jbc.M508381200
id504
pubmed_id16339146
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1(-)
backbone_mutation
backbone_originInvitrogen
backbone_size5428
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
See author's map for more information.
growth strain :
Mammalian expression of human cathepsin B
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3PmeI
cloning_site_5XbaI
promoter
sequencing_primer_3
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAPPS, CPSB, KWE, RECEUP
geneCTSB
id1508
genbank_ids
mutation
namecathepsin B
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagC9 (GTETSQVAPA)
resistance markers :
80
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA