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product summary
company name :
Addgene
product type :
cDNA
product name :
IKK-2 S177E S181E
catalog :
11105
citations: 24
Reference
Mantsounga C, Lee C, Neverson J, Sharma S, Healy A, Berus J, et al. Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-A. Cell Rep. 2022;38:110309 pubmed publisher
Wang W, Gu X, Cheng Z, Lu X, Xie S, Liu X. IKKβ Alleviates Neuron Injury in Alzheimer's Disease via Regulating Autophagy and RIPK1-Mediated Necroptosis. Mol Neurobiol. 2022;59:2407-2423 pubmed publisher
Kang J, Yan J, Ranjan K, Zhang X, Turner J, Abraham C. Myeloid Cell Expression of LACC1 is Required for Bacterial Clearance and Control of Intestinal Inflammation. Gastroenterology. 2020;: pubmed publisher
Herb M, Farid A, Gluschko A, Kronke M, Schramm M. Highly Efficient Transfection of Primary Macrophages with In Vitro Transcribed mRNA. J Vis Exp. 2019;: pubmed publisher
Gruber J, Chen J, Geller B, Jäger N, Lipchik A, Wang G, et al. Chromatin Remodeling in Response to BRCA2-Crisis. Cell Rep. 2019;28:2182-2193.e6 pubmed publisher
Enguita M, Razquin N, Pamplona R, Quiroga J, Prieto J, Fortes P. The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells. Cell Death Dis. 2019;10:14 pubmed publisher
Rodrigues P, Patel S, Harewood L, Olan I, Vojtasova E, Syafruddin S, et al. NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discov. 2018;8:850-865 pubmed publisher
You J, Dooley M, Kim C, Kim E, Xu W, Goodman C, et al. A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling. Sci Signal. 2018;11: pubmed publisher
Marwarha G, Schommer J, Lund J, Schommer T, Ghribi O. Palmitate-induced C/EBP homologous protein activation leads to NF-κB-mediated increase in BACE1 activity and amyloid beta genesis. J Neurochem. 2018;144:761-779 pubmed publisher
Al Huseini I, Ashida N, Kimura T. Deletion of IκB-Kinase β in Smooth Muscle Cells Induces Vascular Calcification Through β-Catenin-Runt-Related Transcription Factor 2 Signaling. J Am Heart Assoc. 2018;7: pubmed publisher
Fusella F, Seclì L, Busso E, Krepelova A, Moiso E, Rocca S, et al. The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis. Nat Commun. 2017;8:1636 pubmed publisher
Jin Y, Stohn J, Wang Q, Nagano K, Baron R, Bouxsein M, et al. Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1. Bone. 2017;97:153-167 pubmed publisher
Averett C, Bhardwaj A, Arora S, Srivastava S, Khan M, Ahmad A, et al. Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk. Carcinogenesis. 2016;37:1052-1061 pubmed publisher
Hedl M, Yan J, Abraham C. IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Cell Rep. 2016;16:2442-55 pubmed publisher
Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
Rodrigues P, Afonso M, Simão A, Borralho P, Rodrigues C, Castro R. Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis. Sci Rep. 2015;5:17528 pubmed publisher
Miyata M, Lee J, Susuki Miyata S, Wang W, Xu H, Kai H, et al. Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M. Nat Commun. 2015;6:6062 pubmed publisher
Tyagi N, Bhardwaj A, Singh A, McClellan S, Carter J, Singh S. p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway. Oncotarget. 2014;5:8778-89 pubmed
Blonska M, Joo D, Nurieva R, Zhao X, Chiao P, Sun S, et al. Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKK? signaling cascade. Sci Signal. 2013;6:ra110 pubmed publisher
Fakhrudin N, Waltenberger B, Cabaravdic M, Atanasov A, Malainer C, Schachner D, et al. Identification of plumericin as a potent new inhibitor of the NF-?B pathway with anti-inflammatory activity in vitro and in vivo. Br J Pharmacol. 2014;171:1676-86 pubmed publisher
Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G. The hypoxia-inducible transcription factor ZNF395 is controlled by I?B kinase-signaling and activates genes involved in the innate immune response and cancer. PLoS ONE. 2013;8:e74911 pubmed publisher
Su J, Zhao P, Kong L, Li X, Yan J, Zeng Y, et al. Trichothecin induces cell death in NF-?B constitutively activated human cancer cells via inhibition of IKK? phosphorylation. PLoS ONE. 2013;8:e71333 pubmed publisher
Kumar S, Chakraborty S, Barbosa C, Brustovetsky T, Brustovetsky N, Obukhov A. Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels. J Cell Physiol. 2012;227:1408-19 pubmed publisher
Mercurio F, Zhu H, Murray B, Shevchenko A, Bennett B, Li J, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997;278:860-6 pubmed
product information
Catalog Number :
11105
Product Name :
IKK-2 S177E S181E
article :
doi10.1126/science.278.5339.860
id469
pubmed_id9346484
bacterial resistance :
Ampicillin
cloning :
backbonepCMV2
backbone_mutation
backbone_origin
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
Mammalian expression of constitutively active human IKK-2
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesIKK-2, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB
geneIKBKB
id3551
genbank_ids
mutationS177E and S181E, constitutively active
nameIKK-2
shRNA_sequence
size2300
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFLAG
resistance markers :
410
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA