This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
IKK-2 K44M
catalog :
11104
citations: 10
Reference
Prescott J, Balmanno K, Mitchell J, Okkenhaug H, Cook S. IKKα plays a major role in canonical NF-κB signalling in colorectal cells. Biochem J. 2022;479:305-325 pubmed publisher
Lin C, Shih M, Chang H, Lin K, Chen L, Huang S, et al. Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity. J Biomed Sci. 2021;28:66 pubmed publisher
Herb M, Gluschko A, Wiegmann K, Farid A, Wolf A, Utermöhlen O, et al. Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO. Sci Signal. 2019;12: pubmed publisher
Al Huseini I, Ashida N, Kimura T. Deletion of IκB-Kinase β in Smooth Muscle Cells Induces Vascular Calcification Through β-Catenin-Runt-Related Transcription Factor 2 Signaling. J Am Heart Assoc. 2018;7: pubmed publisher
Reid M, Lowman X, Pan M, Tran T, Warmoes M, Ishak Gabra M, et al. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016;30:1837-51 pubmed publisher
Hochrainer K, Pejanovic N, Olaseun V, Zhang S, Iadecola C, Anrather J. The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res. 2015;43:9889-904 pubmed publisher
Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G. The hypoxia-inducible transcription factor ZNF395 is controlled by I?B kinase-signaling and activates genes involved in the innate immune response and cancer. PLoS ONE. 2013;8:e74911 pubmed publisher
Cocka L, Bates P. Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities. PLoS Pathog. 2012;8:e1002931 pubmed publisher
Hupalowska A, Pyrzynska B, Miaczynska M. APPL1 regulates basal NF-?B activity by stabilizing NIK. J Cell Sci. 2012;125:4090-102 pubmed publisher
Mercurio F, Zhu H, Murray B, Shevchenko A, Bennett B, Li J, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997;278:860-6 pubmed
product information
Catalog Number :
11104
Product Name :
IKK-2 K44M
article :
doi10.1126/science.278.5339.860
id469
pubmed_id9346484
bacterial resistance :
Ampicillin
cloning :
backbonepCMV2
backbone_mutation
backbone_origin
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
NGS found additional P668H mutation.
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3NA
cloning_site_5NA
promoter
sequencing_primer_3hGHpA-R
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesIKK-2, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB
geneIKBKB
id3551
genbank_ids
mutationK44M, kinase inactive
nameIKK-2
shRNA_sequence
size2300
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFLAG
resistance markers :
410
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA