This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
IKK-2 WT
catalog :
11103
citations: 12
Reference
Prescott J, Balmanno K, Mitchell J, Okkenhaug H, Cook S. IKKα plays a major role in canonical NF-κB signalling in colorectal cells. Biochem J. 2022;479:305-325 pubmed publisher
Herb M, Farid A, Gluschko A, Kronke M, Schramm M. Highly Efficient Transfection of Primary Macrophages with In Vitro Transcribed mRNA. J Vis Exp. 2019;: pubmed publisher
Cockman M, Lippl K, Tian Y, Pegg H, Figg W, Abboud M, et al. Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. elife. 2019;8: pubmed publisher
Herb M, Gluschko A, Wiegmann K, Farid A, Wolf A, Utermöhlen O, et al. Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO. Sci Signal. 2019;12: pubmed publisher
Ishak Gabra M, Yang Y, Lowman X, Reid M, Tran T, Kong M. IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation. Oncogenesis. 2018;7:93 pubmed publisher
Fusella F, Seclì L, Busso E, Krepelova A, Moiso E, Rocca S, et al. The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis. Nat Commun. 2017;8:1636 pubmed publisher
König H, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, et al. NF-κB regulates neuronal ankyrin-G via a negative feedback loop. Sci Rep. 2017;7:42006 pubmed publisher
Reid M, Lowman X, Pan M, Tran T, Warmoes M, Ishak Gabra M, et al. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016;30:1837-51 pubmed publisher
Jordanovski D, Herwartz C, Pawlowski A, Taute S, Frommolt P, Steger G. The hypoxia-inducible transcription factor ZNF395 is controlled by I?B kinase-signaling and activates genes involved in the innate immune response and cancer. PLoS ONE. 2013;8:e74911 pubmed publisher
Peng Y, Zheng J, Zhou Y, Li J. Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-?B signaling pathway with distinct mechanisms. Acta Pharmacol Sin. 2013;34:939-50 pubmed publisher
Jin S, Mutvei A, Chivukula I, Andersson E, Ramsköld D, Sandberg R, et al. Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKK?/IKK?. Oncogene. 2013;32:4892-902 pubmed publisher
Mercurio F, Zhu H, Murray B, Shevchenko A, Bennett B, Li J, et al. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science. 1997;278:860-6 pubmed
product information
Catalog Number :
11103
Product Name :
IKK-2 WT
article :
doi10.1126/science.278.5339.860
id469
pubmed_id9346484
bacterial resistance :
Ampicillin
cloning :
backbonepCMV2
backbone_mutation
backbone_origin
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesIKK-2, IKK-beta, IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB
geneIKBKB
id3551
genbank_ids
mutation
nameIKK-2
shRNA_sequence
size2300
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFLAG
resistance markers :
410
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA