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product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA4 myc PGC-1 alpha
catalog :
10974
citations: 25
Reference
Ogden S, Carys K, Ahmed I, Bruce J, Sharrocks A. Regulatory chromatin rewiring promotes metabolic switching during adaptation to oncogenic receptor tyrosine kinase inhibition. Oncogene. 2022;41:4808-4822 pubmed publisher
Larson Casey J, Gu L, Davis D, Cai G, Ding Q, He C, et al. Post-translational regulation of PGC-1α modulates fibrotic repair. FASEB J. 2021;35:e21675 pubmed publisher
Inak G, Rybak Wolf A, Lisowski P, Pentimalli T, Jüttner R, Glažar P, et al. Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome. Nat Commun. 2021;12:1929 pubmed publisher
Kim S, Piao S, Lee I, Nagar H, Choi S, Shin N, et al. CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells. Free Radic Biol Med. 2020;150:161-171 pubmed publisher
Gu L, Larson Casey J, Andrabi S, Lee J, Meza Perez S, Randall T, et al. Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis. Redox Biol. 2019;26:101307 pubmed publisher
Liu L, He Z, Xu L, Lu L, Feng H, Leong D, et al. CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad. Ann N Y Acad Sci. 2019;1442:153-164 pubmed publisher
Wu M, Chen Y, Kim M, Chang C, Gampala S, Zhang Y, et al. Epithelial-Mesenchymal Transition Directs Stem Cell Polarity via Regulation of Mitofusin. Cell Metab. 2019;29:993-1002.e6 pubmed publisher
Chen S, Bastarrachea R, Shen J, Laviada Nagel A, Rodriguez Ayala E, Nava González E, et al. Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy. Gene Ther. 2018;25:497-509 pubmed publisher
Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher
Huang C, Wang K, Yang Y, Chiou C, Tan C, Lin Y, et al. Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation. Phytomedicine. 2018;39:75-84 pubmed publisher
Kim B, Jung J, Jung J, Han Y, Suh D, Kim H, et al. PGC1? induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells. Oncotarget. 2017;8:60299-60311 pubmed publisher
Ahmad F, Patrick S, Sheikh T, Sharma V, Pathak P, Malgulwar P, et al. Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma. J Neurochem. 2017;143:671-683 pubmed publisher
Bastarrachea R, Chen J, Kent J, Nava González E, Rodriguez Ayala E, Daadi M, et al. Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design. IUBMB Life. 2017;69:745-755 pubmed publisher
Choi H, Kim H, Park J, Kim I, Bae E, Ma S, et al. PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells. Sci Rep. 2017;7:4319 pubmed publisher
Corso Díaz X, de Leeuw C, Alonso V, Melchers D, Wong B, Houtman R, et al. Co-activator candidate interactions for orphan nuclear receptor NR2E1. BMC Genomics. 2016;17:832 pubmed
Besse Patin A, Léveillé M, Oropeza D, Nguyen B, Prat A, Estall J. Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease. Gastroenterology. 2017;152:243-256 pubmed publisher
Nagarajan A, Petersen M, Nasiri A, Butrico G, Fung A, Ruan H, et al. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun. 2016;7:12639 pubmed publisher
Vaarmann A, Mandel M, Zeb A, Wareski P, Liiv J, Kuum M, et al. Mitochondrial biogenesis is required for axonal growth. Development. 2016;143:1981-92 pubmed publisher
Xiong Z, Choi J, Wang K, Zhang H, Tariq Z, Wu D, et al. Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell. 2016;15:279-90 pubmed publisher
Liu Z, Liu Y, Gao R, Li H, Dunn T, Wu P, et al. Ethanol suppresses PGC-1? expression by interfering with the cAMP-CREB pathway in neuronal cells. PLoS ONE. 2014;9:e104247 pubmed publisher
Song W, Song Y, Kincaid B, Bossy B, Bossy Wetzel E. Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1?. Neurobiol Dis. 2013;51:72-81 pubmed publisher
Rossi M, Colecchia D, Iavarone C, Strambi A, Piccioni F, Verrotti di Pianella A, et al. Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor ? (ERR?) cellular localization and inhibits its transcriptional activity. J Biol Chem. 2011;286:8507-22 pubmed publisher
Alvarez Guardia D, Palomer X, Coll T, Davidson M, Chan T, Feldman A, et al. The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells. Cardiovasc Res. 2010;87:449-58 pubmed publisher
Wareski P, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, et al. PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem. 2009;284:21379-85 pubmed publisher
Ichida M, Nemoto S, Finkel T. Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha). J Biol Chem. 2002;277:50991-5 pubmed
product information
Catalog Number :
10974
Product Name :
pcDNA4 myc PGC-1 alpha
article :
doi10.1074/jbc.M210262200
id438
pubmed_id12397057
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA4 myc his
backbone_mutation
backbone_originInvitrogen
backbone_size5075
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
Mammalian expression of PGC-1a with myc and his tags
origin :
37
pi :
alt_names
PPARGC1
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3BGHRev
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesLEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1
genePPARGC1A
id10891
genbank_ids
NP_037393
mutation
namePGC-1 alpha
shRNA_sequence
size2400
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagMyc
locationC terminal on backbone
tagHis
resistance markers :
146
tags :
High Copy
terms :
Zeocin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA