This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pMKO.1 puro PTEN shRNA
catalog :
10669
citations: 5
Reference
Mondal S, Bhattacharya K, Mandal C. Nutritional stress reprograms dedifferention in glioblastoma multiforme driven by PTEN/Wnt/Hedgehog axis: a stochastic model of cancer stem cells. Cell Death Discov. 2018;4:110 pubmed publisher
Mansour W, Tennstedt P, Volquardsen J, Oing C, Kluth M, Hube Magg C, et al. Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer. Sci Rep. 2018;8:3947 pubmed publisher
Wozniak D, Kajdacsy Balla A, Macias V, Ball Kell S, Zenner M, Bie W, et al. PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer. Nat Commun. 2017;8:1508 pubmed publisher
Qiu H, Li J, Clark L, Jackson A, Zhang L, Guo H, et al. JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer. Oncotarget. 2016;7:66809-66821 pubmed publisher
Jagan I, Fatehullah A, Deevi R, Bingham V, Campbell F. Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARγ-targeted therapy. Oncogene. 2013;32:1305-15 pubmed publisher
product information
Catalog Number :
10669
Product Name :
pMKO.1 puro PTEN shRNA
article :
doi
id355
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepMKO.1
backbone_mutation
backbone_origin
backbone_size6700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
RNAi
growth notes :
siRNA sequence is ACTTGAAGGCGTATACAGGA.
origin :
37
pi :
alt_names
PTEN
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5AgeI
promoter
sequencing_primer_3pBABE-3
sequencing_primer_5pLXSN 5'
site_3_destroyed
site_5_destroyed1
entrez_gene
aliases10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
genePTEN
id5728
genbank_ids
mutation
namePTEN shRNA
shRNA_sequence
size58
species
9606
Homo sapiens
tags
resistance markers :
184
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA