This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pJ4M/TDP-43
catalog :
104480
citations: 16
Reference
Zibold J, Lessard L, Picard F, da Silva L, Zadorozhna Y, Streichenberger N, et al. The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis. Brain. 2023;: pubmed publisher
Abayev Avraham M, Salzberg Y, Gliksberg D, Oren Suissa M, Rosenzweig R. DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones. Nat Commun. 2023;14:7066 pubmed publisher
Riemenschneider H, Simonetti F, Sheth U, Katona E, Roth S, Hutten S, et al. Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo. Acta Neuropathol Commun. 2023;11:112 pubmed publisher
P xe9 rez Berlanga M, Wiersma V, Zbinden A, De Vos L, Wagner U, Foglieni C, et al. Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns. EMBO J. 2023;:e111719 pubmed publisher
Ervilha Pereira P, Schuermans N, Meylemans A, LeBlanc P, Versluys L, Copley K, et al. C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD. Acta Neuropathol. 2023;145:793-814 pubmed publisher
Shen H, Yanas A, Owens M, Zhang C, Fritsch C, Fare C, et al. Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation. Mol Cell. 2022;: pubmed publisher
Peinado J, Chaplot K, Jarvela T, Barbieri E, Shorter J, Lindberg I. Sequestration of TDP-43216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone. ACS Chem Neurosci. 2022;13:1651-1665 pubmed publisher
Ma X, Prudencio M, Koike Y, Vatsavayai S, Kim G, Harbinski F, et al. TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A. Nature. 2022;603:124-130 pubmed publisher
Hallegger M, Chakrabarti A, Lee F, Lee B, Amalietti A, Odeh H, et al. TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 2021;184:4680-4696.e22 pubmed publisher
Hutten S, Usluer S, Bourgeois B, Simonetti F, Odeh H, Fare C, et al. Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions. Cell Rep. 2020;33:108538 pubmed publisher
Perdikari T, Murthy A, Ryan V, Watters S, Naik M, Fawzi N. SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs. EMBO J. 2020;:e106478 pubmed publisher
Babinchak W, Dumm B, Venus S, Boyko S, Putnam A, Jankowsky E, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nat Commun. 2020;11:5574 pubmed publisher
Perdikari T, Murthy A, Ryan V, Watters S, Naik M, Fawzi N. SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins. bioRxiv. 2020;: pubmed publisher
Mann J, Gleixner A, Mauna J, Gomes E, DeChellis Marks M, Needham P, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. 2019;102:321-338.e8 pubmed publisher
McGurk L, Gomes E, Guo L, Mojsilovic Petrovic J, Tran V, Kalb R, et al. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. Mol Cell. 2018;71:703-717.e9 pubmed publisher
Wang A, Conicella A, Schmidt H, Martin E, Rhoads S, Reeb A, et al. A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J. 2018;37: pubmed publisher
product information
Catalog Number :
104480
Product Name :
pJ4M/TDP-43
article :
doi10.15252/embj.201797452
id28192246
pubmed_id29438978
bacterial resistance :
Kanamycin
cloning :
backbonepJ4M
backbone_mutation
backbone_origin
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Bacterial Expression
growth strain :
bacterial expression of TDP-43
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3unknown
cloning_site_5unknown
promoter
sequencing_primer_3
sequencing_primer_5
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesALS10, TDP-43
geneTARDBP
id23435
genbank_ids
mutation
nameTDP-43
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagMBP-6xHis
resistance markers :
3468
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA