Tet2 antibody (mAb) | Active Motif 61389 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Tet2 antibody (mAb)

catalog :

61389

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

21F11

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 1:500; loading ...; fig 1b immunocytochemistry; human; 1:100; loading ...; fig 2f	Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed publisher
western blot; human; loading ...; fig 2c	Gong F, Guo Y, Niu Y, Jin J, Zhang X, Shi X, et al. Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma. Oncotarget. 2017;8:315-328 pubmed publisher
western blot; human; fig 6	Wallner S, Schröder C, Leitão E, Berulava T, Haak C, Beißer D, et al. Epigenetic dynamics of monocyte-to-macrophage differentiation. Epigenetics Chromatin. 2016;9:33 pubmed publisher

product information

Catalog Number :

61389

Product Name :

Tet2 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

21F11

Isotype :

IgG1k

CrossReactivity :

Human

Background :

Tet2 (tet methylcytosine dioxygenase 2) catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation and differentiation in the case of inflammation by regulating gene expression and macrophage differentiation.

Immunogen :

This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.

Uses :

IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.