SIRT2 antibody (mAb) | Active Motif 61365 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

SIRT2 antibody (mAb)

catalog :

61365

quantity :

100 ug

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

7G5

reactivity :

human

application :

western blot

product information

Catalog Number :

61365

Product Name :

SIRT2 antibody (mAb)

Host Species :

Rat

Clonality :

Monoclonal

Size :

100 ug

Clone :

7G5

Isotype :

IgG2a

CrossReactivity :

Human

Background :

SIRT2 (sirtuin 2) is a member of the SIR2 / Sirtuin family of NAD-dependant deacetylase enzymes. It has multiple targets for deacetylation, including tubulin, P53, HOXA10, FOXO3A, P300, FOXO1. SIRT2 suppresses adipogenesis by deacetylating FOXO1, promoting the binding of FOXO1 to PPARM-NM-3 and subsequent repression of PPARM-NM-3 mediated transcriptional activation. Similar to SIRT1, SIRT2 also deacetylates H4AcK16 similar to SIRT1, SIRT2 deacetylates histone H4 at lysine 16. SIRT2 is present in the cytoplasm during most of the cell cycle except in the G2/M transition and in mitosis, where it is found in the nucleus and in contact with chromatin and required for exit from mitosis.

Immunogen :

This antibody was raised against a synthetic peptide corresponding to human SIRT2 surrounding serine 331. This antibody recognizes both the unphosporylated and the Ser-331 phosphorylated form of SIRT2.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: The use of this antibody is described in the following Reference:WB: Pandithage, R. et al. (2008) J Cell Biol. 180:915-929.