SIRT2 phospho Ser331 antibody (mAb) | Active Motif 61363 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

SIRT2 phospho Ser331 antibody (mAb)

catalog :

61363

quantity :

100 ug

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

6B5

reactivity :

human

application :

western blot

product information

Catalog Number :

61363

Product Name :

SIRT2 phospho Ser331 antibody (mAb)

Host Species :

Rat

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Size :

100 ug

Clone :

6B5

Isotype :

IgG2a

CrossReactivity :

Human

Background :

SIRT2 (sirtuin 2) is a member of the SIR2 / Sirtuin family of NAD-dependant deacetylase enzymes. It has multiple targets for deacetylation, including tubulin, P53, HOXA10, FOXO3A, P300, FOXO1. SIRT2 suppresses adipogenesis by deacetylating FOXO1, promoting the binding of FOXO1 to PPARM-NM-3 and subsequent repression of PPARM-NM-3 mediated transcriptional activation. Similar to SIRT1, SIRT2 also deacetylates H4AcK16 similar to SIRT1, SIRT2 deacetylates histone H4 at lysine 16. SIRT2 is present in the cytoplasm during most of the cell cycle except in the G2/M transition and in mitosis, where it is found in the nucleus and in contact with chromatin and required for exit from mitosis. Ser-331 is phosphorylated by the cyclin kinases Cdk2 and Cdk5 and this phosphorylation inhibits SIRT2M-bM-^@M-^Ys catalytic activity.

Immunogen :

This antibody was raised against a synthetic peptide corresponding to human SIRT2 phosphorylated at Serine 331.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: The use of this antibody is described in the following Reference:WB: Pandithage, R. et al. (2008) J Cell Biol. 180:915-929.