MLL antibody (pAb) | Active Motif 61295 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

MLL antibody (pAb)

catalog :

61295

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

product information

Catalog Number :

61295

Product Name :

MLL antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ug

Isotype :

IgG

CrossReactivity :

Human, Mouse

Background :

MLL (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)) is a histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1 /MLL complex, a multiprotein complex that mediates both methylation of M-bM-^@M-^XLys-4M-bM-^@M-^Y of histone H3 (H3K4me) complex and acetylation of M-bM-^@M-^XLys-16M-bM-^@M-^Y of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.

Immunogen :

This MLL antibody was raised against a recombinant protein corresponding to amino acids 2829-2883 of human MLL.

Uses :

ChIP, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: The use of this antibody is described in the following references:ChIP & WB: Dou, Y., et al. (2005) Cell. 121:873-885WB: Li, X., et al. (2009) Mol Cell. 36:290-301