Bcl6 antibody (mAb) | Active Motif 61193 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Bcl6 antibody (mAb)

catalog :

61193

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

IG191E

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

61193

Product Name :

Bcl6 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

IG191E

Isotype :

IgG1

CrossReactivity :

Human

Background :

Bcl6 (B-cell lymphoma 6 protein, Bcl5, LAZ3, ZBTB27, ZNF51) is sequence-specific transcriptional repressor that is required for the formation of lymph node germinal centers (GC). Bcl6 is a member of the BTB-POZ family of transcriptional regulators and contains six Kruppel-type zinc fingers. The POZ domain in the amino terminus of Bcl6 is involved in the recruitment of corepressor proteins including NCoR, BCoR, SMRT, Mi-2/NURD and several HDACs. Bcl6 promotes proliferative expansion of B-cells in the germinal center through repression of genes regulating cell cycle and differentiation. Bcl6 also suppresses the DNA damage response, to prevent class-switch recombination being repaired. Unregulated expression of Bcl6 is involved in the development of many B-cell lymphomas.

Immunogen :

This Bcl6 antibody was raised against a full-length protein corresponding to human Bcl6.

Uses :

IHC, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references: IHC: Garcia JF et al (2006) J Histochem Cytochem 54: 31-38; Garcia JF et al (2006) Haematologica 91: 467-474. WB: Garcia JF et al (2006) J Histochem Cytochem 54: 31-38.