3-Methylcytosine (3-mC) antibody (pAb) | Active Motif 61179 product information

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product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

3-Methylcytosine (3-mC) antibody (pAb)

catalog :

61179

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

product information

Catalog Number :

61179

Product Name :

3-Methylcytosine (3-mC) antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Methylated

Size :

100 ul

Isotype :

Serum

CrossReactivity :

Human, Mouse, Other (Wide Range)

Background :

Methylation of DNA can occur non-enzymatically at the nitrogen-three of the cytosine base through spontaneous exposure to endogenous S-adenosyl methionine (SAM). The resulting 3-methylcytosine (3-mC) is mutagenic and must be repaired, which occurs in humans through the base excision repair (BER) or dealkylation via human homologues of the E. coli AlkB protein. 3-methylcytosine is present in human cell lines and increased levels of 3-mC impair proliferation.

Immunogen :

This 3-methylcytosine antibody was raised against 3-methylcytidine conjugated to KLH and recognizes 3-methylcytosine .

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references:DB: Dango S et al. (2011) Mol Cell 44: 373-384.