Notch1 antibody (mAb) | Active Motif 61147 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Notch1 antibody (mAb)

catalog :

61147

quantity :

100 ug

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

ICN 5B5

reactivity :

human, rat

application :

western blot

product information

Catalog Number :

61147

Product Name :

Notch1 antibody (mAb)

Host Species :

Rat

Clonality :

Monoclonal

Size :

100 ug

Clone :

ICN 5B5

Isotype :

IgG2b

CrossReactivity :

Human, Rat

Background :

Notch1 is a member of the Notch family of receptors, which make up a highly conserved cell signaling system. Notch1 functions as a ligand-activated transcription factor that directly transduces extracellular signals in the cell surface into changes in gene expression in the nucleus. Notch1 is membrane bound, serving as an extracellular receptor for the Delta and Serrate family of ligands. Upon activation, the intracellular domain is cleaved and rapidly translocates into the nucleus where it forms a transcriptional complex with the RBP-J DNA binding protein and activates gene expression via recruitment of co-activators of the MAML family. Notch receptors play a critical role in cell fate specification during development and participate in multiple biological processes. Notch signaling is required for undifferentiated embryonic stem cells (ESCs) to participate in the formation of all three embryonic germ layers.

Immunogen :

This Notch1 antibody was raised against a recombinant protein corresponding to the intracellular domain of human Notch1.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.