SMARCAL1 / HARP antibody (mAb) | Active Motif 61115 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

SMARCAL1 / HARP antibody (mAb)

catalog :

61115

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B10

reactivity :

human, mouse, bovine

application :

western blot, immunoprecipitation

product information

Catalog Number :

61115

Product Name :

SMARCAL1 / HARP antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

4B10

Isotype :

IgG1

CrossReactivity :

Bovine, Human, Mouse

Background :

SMARCAL1 / HARP (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, HepA-related protein, DNA-dependent ATPase A) is a member of the SWI / SNF family of ATPases and chromatin remodeling proteins. Unlike other SWI / SNF family members, SMARCAL1 / HARP has not been shown to remodel chromatin, but possesses an ATP-dependent annealing helicase activity. SMARCAL1 reanneals single stranded DNA bubbles in DNA at DNA replication forks that are bound by Replication Protein A (RPA). Defects in SMARCAL1 / HARP are a cause of Schimke immuno-osseous dysplasia (SIOD) SIOD causes spondyloepiphyseal dysplasia (a disorder of bone growth that results in short stature, skeletal abnormalities, and problems with vision and hearing), renal dysfunction and T-cell immunodeficiency.

Immunogen :

This SMARCAL1 / HARP antibody was raised against purifed bovine SMARCAL1 / HARP protein.

Uses :

IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: IP: Mesner LD et al (1993) Biochemistry 32: 7772-7778.WB: Mesner LD et al (1991) Biochemistry 30: 11490-11494; Mesner LD et al (1993) Biochemistry 32: 7772-7778.