TWIST antibody (mAb) | Active Motif 61097 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

TWIST antibody (mAb)

catalog :

61097

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human	Ezponda T, Popovic R, Shah M, Martinez Garcia E, Zheng Y, Min D, et al. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene. 2013;32:2882-90 pubmed publisher

product information

Catalog Number :

61097

Product Name :

TWIST antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Isotype :

IgG1

CrossReactivity :

Human, Mouse

Background :

TWIST is a regulator of transcription that serves as a master regulator of embryonic morphogenesis. Through its bHLH motif it interacts with many different transcription factors to affect multiple pathways of gene expression. TWIST plays a pivotal role in mesodermal, myoblast, and osteoblast differentiation. TWIST is involved in the epithelialM-bM-^@M-^Smesenchymal transition (EMT), a period during embryonic development characterized by loss of cell adhesion and increased cell mobility, essential events for mesoderm and neural tube formation. The EMT shares many features of metastatic cancer, and elevated levels of TWIST are observed in many types of cancer. Mutations in the gene encoding TWIST have been associated with Saethre-Chotzen syndrome, an an inherited developmental disorder characterized by skull deformations, limb abnormalities, and facial dysmorphisim.

Immunogen :

This TWIST antibody was raised against a recombinant protein corresponding to full-length mouse TWIST.

Uses :

IF, IHC, WB

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references: IF: Kida Y et al. (2007) J Histochem Cytochem 55: 661-673.IHC: Gitelman I et al. (1997) Dev Biol 189: 205-214; Eckert MA et al. (2011) Cancer Cell 19: 372-386; Kida Y et al. (2007) J Histochem Cytochem 55: 661-673.WB: Gitelman I et al. (1997) Dev Biol 189: 205-214; Casas et al. (2011) Cancer Res 71: 245-254.