SIP1 antibody (mAb) | Active Motif 61095 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

SIP1 antibody (mAb)

catalog :

61095

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

600000

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

61095

Product Name :

SIP1 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

600000

Isotype :

IgG2a

CrossReactivity :

Human

Background :

SIP1 (Smad-interacting protein 1, aka ZEB2, Zinc finger E-box-binding homeobox 2) is a sequence-specific DNA binding protein and transcriptional repressor that is involved in normal embryonic development of neural structures and the neural crest. SIP1 belongs to the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins and contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1 interacts directly with activated forms of SMAD1, SMAD2 and SMAD3, as well as CBX4 and CTBP1. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR).

Immunogen :

This SIP1 antibody was raised against a recombinant protein corresponding to amino acids 1-360 of human SIP1.

Uses :

IF, IHC, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: IF: Oztas E et al. (2010) Exp Mol Path 89: 182-189.IHC: Oztas E et al. (2010) Exp Mol Path 89: 182-189.WB: Oztas E et al. (2010) Exp Mol Path 89: 182-189.