BLM antibody (pAb) | Active Motif 61055 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

BLM antibody (pAb)

catalog :

61055

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Catalog Number :

61055

Product Name :

BLM antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ul

Isotype :

IgG

CrossReactivity :

Human

Background :

BLM (Bloom Syndrome protein, RECQ2, RECQL3) is a DNA helicase similar to E. coli RecQ protein that is mutated in patients with Bloom Syndrome, an autosomal recessive disorder characterized by growth deficiency, sun sensitive skin, cancer predisposition and chromosomal instability. The five human RecQ helicases play critical roles in DNA recombination, replication and repair. BLM helps to resolve aberrant chromosome structures generated during DNA replication. It exists in a complex with topoisomerase IIIM-NM-1, RMI1/BLAP75 and RMI2 and it is thought that BLM complexes are recruited to resolve Holliday junction intermediates. BLM is heavily phosphorylated, especially during mitosis. BLM has a role during meiosis as well, as BLM males are sterile and BLM females have reduced fertility.

Immunogen :

This BLM antibody was raised against a peptide within the N-terminal region of human BLM.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.