ATRX antibody (pAb) | Active Motif 61049 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

ATRX antibody (pAb)

catalog :

61049

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Catalog Number :

61049

Product Name :

ATRX antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ul

Isotype :

IgG

CrossReactivity :

Human

Background :

ATRX (alpha thalassemia/mental retardation syndrome X-linked protein, X-linked helicase II, XNP) is a transcriptional regulator and a member of the SWI/SNF family of chromatin remodeling proteins. It contains an SNF2 domain and helicase domain, and a PHD finger. ATRX undergoes cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in interphase gene regulation and chromosomal segregation in mitosis. Mutations of the ATRX gene are associated with an X-linked mental retardation syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes.

Immunogen :

This ATRX antibody was raised against a peptide within the C-terminus of human ATRX.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.