SIRT2 antibody (pAb) | Active Motif 61043 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

SIRT2 antibody (pAb)

catalog :

61043

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

61043

Product Name :

SIRT2 antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ul

Isotype :

Serum

CrossReactivity :

Human

Background :

SIRT2 is a member of the SIR2 / Sirtuin family of NAD-dependant deacetylase enzymes. It has multiple targets for deacetylation, including tubulin, P53, HOXA10, FOXO3A, P300, FOXO1. SIRT2 suppresses adipogenesis by deacetylating FOXO1, promoting the binding of FOXO1 to PPARM-NM-3 and subsequent repression of PPARM-NM-3 mediated transcriptional activation. Similar to SIRT1, SIRT2 also deacetylates H4AcK16 similar to SIRT1, SIRT2 deacetylates histone H4 at lysine 16. SIRT2 is present in the cytoplasm during most of the cell cycle except in the G2/M transition and in mitosis, where it is found in the nucleus and in contact with chromatin and required for exit from mitosis.

Immunogen :

This SIRT2 antibody was raised against a peptide within the C-terminal region of human SIRT2 protein.

Uses :

IF, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references: IF: Dryden SC et al. (2003) Molec Cell Biol 23: 3173M-bM-^@M-^S3185.WB: Dryden SC et al. (2003) Molec Cell Biol 23: 3173M-bM-^@M-^S3185.