Histone H2BS14ph antibody (mAb) | Active Motif 61011 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Histone H2BS14ph antibody (mAb)

catalog :

61011

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MABI 0251

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

61011

Product Name :

Histone H2BS14ph antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Size :

100 ug

Clone :

MABI 0251

Isotype :

IgG1

CrossReactivity :

Human, Other (Wide Range)

Background :

Histone H2B is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points. Histone H1 is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins. H2B is phosphorylated at serine 14 in response to DNA damage (dependant upon PI3 kinase kinase activity) and during apoptosis.by the Mst1 kinase.

Immunogen :

This Histone H2B phospho Ser14 antibody was raised against a peptide containing phospho Ser14 of human histone H2B.

Uses :

IF, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: The creation of this antibody was described in Kimura, H. et al. (2006) J Cell Biol. 175(3): 389-400.