Livin/ML-IAP antibody (mAb) | Active Motif 40958 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Livin/ML-IAP antibody (mAb)

catalog :

40958

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

88C570

The same clone is also sold as:

Rockland Immunochemicals: 200-301-H90
Invitrogen: MA5-16196
Novus Biologicals: NB100-56548, NBP2-33225
OriGene: TA336400

reactivity :

human

application :

western blot, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Ruckert F, Dawelbait G, Winter C, Hartmann A, Denz A, Ammerpohl O, et al. Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis. PLoS ONE. 2010;5:e12243 pubmed publisher

product information

Catalog Number :

40958

Product Name :

Livin/ML-IAP antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

88C570

Isotype :

IgG1

CrossReactivity :

Human

Background :

Livin (ML-IAP or BIRC7) protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, Livin (ML-IAP or BIRC7) inhibits Caspase-3 and proteolytic activation of pro-Caspase-9. Isoform 1 of Livin (ML-IAP or BIRC7) blocks staurosporine-induced apoptosis, while isoform 2 blocks etoposide-induced apoptosis.

Immunogen :

This antibody was raised against a GST-fusion protein corresponding to human Livin/ML-IAP.

Uses :

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.