IKKM-NM-3 antibody (mAb) | Active Motif 40908 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

IKKM-NM-3 antibody (mAb)

catalog :

40908

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

46B844

The same clone is also sold as:

Invitrogen: MA1-41219
Santa Cruz Biotechnology: sc-52930
Novus Biologicals: NB100-56532, NBP2-33220
Rockland Immunochemicals: 200-301-H86
OriGene: TA336392

reactivity :

human, rat

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:500	Han H, Karabiyikoglu M, Kelly S, Sobel R, Yenari M. Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab. 2003;23:589-98 pubmed

product information

Catalog Number :

40908

Product Name :

IKKM-NM-3 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

46B844

Isotype :

IgG1

CrossReactivity :

Human

Background :

IKKM-NM-2 (IM-NM-:B Kinase beta subunit) M-bM-^@M-^S The IM-NM-:B Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFM-NM-:B (NFM-NM-:B p50 and NFM-NM-:B p65). The IKK complex is composed of two catalytic subunits (IKKM-NM-1 and IKKM-NM-2) and a regulatory subunit (IKKM-NM-3).NFM-NM-:B signaling is negatively regulated by the sequestration of the NFM-NM-:B complex in the cytoplasm by its association with the IM-NM-:B family of inhibitory proteins. Upon its activation, the IKK complex phosphorylates IM-NM-:BM-NM-1 at Ser32 and Ser36. This results ultimately in the degradation of IM-NM-:B and the activation and nuclear translocation of NFM-NM-:B.While both IKK-alpha and IKK-beta subunits are Ser/Thr kinases, IKK beta appears to be the principal kinase, as IKKM-NM-1 is not required for activation of the IKK complex and the subsequent degradation of IM-NM-:BM-NM-1. Once activated, IKKM-NM-2 autophosphorylates, which decreases IKK activity, thereby preventing a prolonged activation of inflammation.

Immunogen :

This antibody was raised against a full-length protein corresponding to human IKKM-NM-3.

Uses :

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.