IKKM-NM-1 antibody (mAb) | Active Motif 40905 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

IKKM-NM-1 antibody (mAb)

catalog :

40905

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14A231

The same clone is also sold as:

Abnova: MAB0052
Rockland Immunochemicals: 200-301-H82
Novus Biologicals: NBP2-27409, NB100-56704
Invitrogen: MA5-16157
Santa Cruz Biotechnology: sc-52932
OriGene: TA336452

reactivity :

human, mouse

application :

western blot, immunoprecipitation

product information

Catalog Number :

40905

Product Name :

IKKM-NM-1 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

14A231

Isotype :

IgG1

CrossReactivity :

Human, Mouse

Background :

IKKM-NM-1 (IM-NM-:B Kinase alpha subunit) M-bM-^@M-^S The IM-NM-:B Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFM-NM-:B (NFM-NM-:B p50 and NFM-NM-:B p65). The IKK complex is composed of two catalytic subunits (IKKM-NM-1 and IKKM-NM-2) and a regulatory subunit (IKKM-NM-3).NFM-NM-:B signaling is negatively regulated by the sequestration of the NFM-NM-:B complex in the cytoplasm by its association with the IM-NM-:B family of inhibitory proteins. Upon its activation, the IKK complex phosphorylates IM-NM-:BM-NM-1 at Ser32 and Ser36. This results ultimately in the degradation of IM-NM-:B and the activation and nuclear translocation of NFM-NM-:B. While both IKK-alpha and IKK-beta subunits are Ser/Thr kinases, IKK-beta appears to be the principal kinase, as IKKM-NM-1 is not required for activation of the IKK complex and the subsequent degradation of IM-NM-:BM-NM-1.

Immunogen :

This antibody was raised against a full-length protein corresponding to human IKKM-NM-1.

Uses :

IP, WB

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.