DAX-1 / NR0B1 antibody (mAb) | Active Motif 39983 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

DAX-1 / NR0B1 antibody (mAb)

catalog :

39983

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1DA-2F4

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Fujii S, Nishikawa Torikai S, Futatsugi Y, Toyooka Y, Yamane M, Ohtsuka S, et al. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells. Sci Rep. 2015;5:9146 pubmed publisher

product information

Catalog Number :

39983

Product Name :

DAX-1 / NR0B1 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

1DA-2F4

Isotype :

IgG1k

CrossReactivity :

Human, Mouse, Rat

Background :

DAX-1 (DSS-AHC critical region on the X chromosome protein 1, NR0B1, Nuclear receptor subfamily 0 group B member 1) is an orphan nuclear receptor and a component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. DAX-1 / NR0B1 inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. It may also have a role in embryonic development and in the maintenance of embryonic stem cell pluripotency as it up-regulates Oct-4 expression ES cells. Defects in DAX-1 are a cause of dosage-sensitive sex reversal (DSSR) and X-linked adrenal hypoplasia congenital (XL-AHC). DSSR results from a duplication of the region of the X-chromosome containing DAX-1, resulting in males with two copies of DAX-1, which inhibits normal testis formation, and thus XY individuals develop as females. XL-AHC is a developmental disorder of the adrenal gland, characterized by a structural disorganization of the glands. Hypogonadotropic hypogonadism (HHG) is frequently associated with this disorder. HHG is a condition resulting from or characterized by abnormally decreased gonadal function, with retardation of growth and sexual development.

Immunogen :

This DAX-1 / NR0B1 antibody was raised against a peptide corresponding to amino acids 135-166 of human DAX-1 / NR0B1.

Uses :

ELISA, ICC, IF, IHC, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references: IF: Battista MC et al. (2005) J Clin Endo Metabol 90: 5426-5431. IHC: Battista MC et al. (2005) J Clin Endo Metabol 90: 5426-5431. WB: Battista MC et al. (2005) J Clin Endo Metabol 90: 5426-5431.