HP1M-NM-1 antibody (mAb) | Active Motif 39977 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

HP1M-NM-1 antibody (mAb)

catalog :

39977

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2HP-1H5

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig s8	Ando T, Yamayoshi S, Tomita Y, Watanabe S, Watanabe T, Kawaoka Y. The host protein CLUH participates in the subnuclear transport of influenza virus ribonucleoprotein complexes. Nat Microbiol. 2016;1:16062 pubmed publisher
	Tang M, Li Y, Zhang X, Deng T, Zhou Z, Ma W, et al. Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage. J Biol Chem. 2014;289:34024-32 pubmed publisher

product information

Catalog Number :

39977

Product Name :

HP1M-NM-1 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

2HP-1H5

Isotype :

IgG1k

CrossReactivity :

Human, Mouse

Background :

HP1 (Heterochromatin protein 1) is a chromosomal protein that participates in both chromatin packaging and gene silencing. Three HP1 isoforms (M-NM-1, M-NM-2 and M-NM-3) occur in mammals. The chromodomain (Chromatin Organization Modifier) of HP1M-NM-1 is responsible for binding to Histone H3 methyl Lys9, although additional factors are required to specify the HP1 targeting. The chromoshadow domain mediates interactions with a number of nuclear proteins, including SuvH39 (a Histone H3 Lysine methyltransferase), the DNA methyltransferases DNMT1 and DNMT3A or the large subunit of the chromatin assembly factor-1 (CAF-1). Dysfunction of HP1M-NM-1 plays a critical role in tumorigenesis, and is implicated in the invasive/metastatic phenotype of breast cancer.

Immunogen :

This HP1M-NM-1 antibody was raised against a recombinant protein corresponding to amino acids 67-119 of mouse HP1M-NM-1.

Uses :

ChIP, ELISA, ICC, IF, IHC, IP

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references: ChIP: Shestakova EA et al. (2004) Nucl Acid Res 32: 4390-4399.IF: Nielsen AL et al. (1999) EMBO J 22: 6385-6395.