Lamin A/C R482W antibody (mAb) | Active Motif 39963 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Lamin A/C R482W antibody (mAb)

catalog :

39963

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5H8-B4

The same clone is also sold as:

ImmuQuest: IQ546, IQ546HRP
Novus Biologicals: NBP1-77402
Invitrogen: MA5-18063
OriGene: TA309731

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

39963

Product Name :

Lamin A/C R482W antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

5H8-B4

Isotype :

IgG1

CrossReactivity :

Human

Background :

Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamins A and Lamins C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization (laminopathy) results in disruption of DNA replication, transcription and RNA processing. The R482W mutation is involved in Dunnigan-type familial partial lipodystrophy (FPLD), a rare form of insulin resistance.

Immunogen :

This Lamin A/C R482W antibody was raised against a recombinant protein corresponding to amino acids 430-545 of human Lamin A/C containing the R482W substitution.

Uses :

IF, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references:IF, IP & WB: Roblek M et al. (2010) PLoS One 5: e10604.