SREBP-1 antibody (mAb) | Active Motif 39939 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

SREBP-1 antibody (mAb)

catalog :

39939

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

IgG-2A4

The same clone is also sold as:

BD Biosciences: 557036

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; fig 5	Rueda Rincon N, Bloch K, Derua R, Vyas R, Harms A, Hankemeier T, et al. p53 attenuates AKT signaling by modulating membrane phospholipid composition. Oncotarget. 2015;6:21240-54 pubmed
western blot; human; 1:25	DaniÃ«ls V, Smans K, Royaux I, Chypre M, Swinnen J, Zaidi N. Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. PLoS ONE. 2014;9:e106913 pubmed publisher

product information

Catalog Number :

39939

Product Name :

SREBP-1 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

IgG-2A4

Isotype :

IgG

CrossReactivity :

Human

Background :

SREBP-1 and SREBP-2 (Sterol regulatory element-binding protein 1 and 2) are members of the basic-helix-loop-helix-leucine zipper (bHLH-ZIP) family of transcription factors and are involved in the regulation of cholesterol homeostasis. SREBP-1 and SREBP-2 are normally membrane bound at the ER and nuclear envelope, but in sterol-depleted cells, the membrane-bound precursors are cleaved to generate a soluble isoforms that translocate to the nucleus. These active forms, which include the bHLH-ZIP domain, activate transcription of genes involved in the uptake and synthesis of cholesterol.

Immunogen :

This SREBP-1 antibody was raised against a recombinant protein corresponding to amino acids 301-407 of human SREBP-1.

Uses :

IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following publications:IP: Bengoechea-Alonso MT et al. (2005) PNAS 102: 11681-11686.WB: Bengoechea-Alonso MT et al. (2005) PNAS 102: 11681-11686.See also:Swinnen JV et al. (1997) PNAS 94: 12975-12980.Zhang Y et al. (2003) J Lipid Res 44: 356-368.