Suz12 antibody (mAb) | Active Motif 39877 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Suz12 antibody (mAb)

catalog :

39877

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2AO9

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; fig 5b western blot; human; fig 5c	Beltran M, Aparicio Prat E, Mazzolini R, Millanes Romero A, MassÃ³ P, Jenner R, et al. Splicing of a non-coding antisense transcript controls LEF1 gene expression. Nucleic Acids Res. 2015;43:5785-97 pubmed publisher

product information

Catalog Number :

39877

Product Name :

Suz12 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

2AO9

Isotype :

IgG2b

CrossReactivity :

Human

Background :

Suz12 (Suppressor-of-Zeste 12 protein, also designated as ChET9, JJAZ1 protein) is a component of the Polycomb group complexes 2, 3 and 4 (PRC2, PRC3 and PRC4), which also contain the histone methyltransferase EZH2, EED (Embryonic Ectoderm Development protein) protein and the histone-binding proteins RbAP46 and RbAP48. PRC2 is responsible for di- and trimethylation of histone 3 at lysine 27 (Histone H3 dimethyl Lys27 and Histone H3 trimethyl Lys27), which leads to transcriptional repression of the target genes. Suz12 is a nuclear protein belonging to the VEFS family. Suz12 contains a zinc-finger binding motif and a VEFS box, which is required for the interaction between Suz12 and EZH2.

Immunogen :

This Suz12 antibody was raised against a recombinant protein corresponding to full-length human Suz12.

Uses :

ChIP, IF, IHC, IP

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references:IHC: Herranz N et al. (2008) Mol Cell Biol 28: 4772-4781. IP: Pasini D et al. (2008) Genes Dev 22: 1345-1355.