Histone macroH2A1.1 antibody (pAb) | Active Motif 39871 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Histone macroH2A1.1 antibody (pAb)

catalog :

39871

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

39871

Product Name :

Histone macroH2A1.1 antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ug

Isotype :

IgG

CrossReactivity :

Human

Background :

Histone macroH2A1.1 is a histone H2A variant and one of the three members of the macroH2A family. The three macroH2A proteins contain the C-terminal 'macro' domain in addition to the H2A homologous region. This macro domain may bind poly ADP-ribose and other NAD+ metabolites. The macroH2A1.1 and macroH2A1.2 proteins are produced from alternatively spliced transcripts from the macroH2A1 gene while a second distinct macroH2A gene encodes macroH2A2. In mammals, macroH2A is preferentially localized to the inactive X chromosome and in general is proposed to play a role in repressing gene expression. In mice, macroH2A1 is required for the silencing of endogenous retroviruses.

Immunogen :

This macroH2A1.1 antibody was raised against a peptide corresponding to amino acids 198-226 of human macroH2A1.1.

Uses :

IF, IHC, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used in the following references: IF: Sporn J. et al. (2009) Oncogene 8: 3423-3428.IHC: Sporn J. et al. (2009) Oncogene 8: 3423-3428.