Nucleophosmin antibody (pAb) | Active Motif 39849 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Nucleophosmin antibody (pAb)

catalog :

39849

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Catalog Number :

39849

Product Name :

Nucleophosmin antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ul

Isotype :

Serum

CrossReactivity :

Human

Background :

Nucleophosmin (NPM, NPM1, Nucleolar phosphoprotein B23) is a highly phosphorylated nucleolar protein involved in ribosome biogenesis, maintenance of genome stability, is directly implicated in cancer pathogenesis and serves as a histone chaperone. Nucleophosmin is closely related to Nucleoplasmin and shuttles back and forth between the nucleolus and the nucleoplasm. Chromosomal aberrations involving Nucleophosmin were found in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acute myelogenous leukemia. Nucleophosmin has been shown to interact with Nucleolin. AKT1, BRCA1 and BARD1. Mice deficient for Nucleophosmin have severe defects in genome stability due to unrestricted centrosome duplication. Heterozygous Nucleophosmin mutant mice show signs of myelodysplastic syndrome.

Immunogen :

This Nucleophosmin antibody was raised against a peptide within the C-terminal region of human nucleophosmin.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.