MLL1/HRX antibody (mAb) | Active Motif 39829 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

MLL1/HRX antibody (mAb)

catalog :

39829

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N4.4

The same clone is also sold as:

QED Bioscience: 34041

reactivity :

human, mouse

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 2	Aguilar Arnal L, Katada S, Orozco Solis R, Sassone Corsi P. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol. 2015;22:312-8 pubmed publisher

product information

Catalog Number :

39829

Product Name :

MLL1/HRX antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

N4.4

Isotype :

IgG1

CrossReactivity :

Human, Mouse

Background :

MLL1 (Mixed-lineage leukemia protein 1, KMT2A, TRX1, HRX1, ALL1) is a SET-domain containing histone methyltransferase specific for lysine 4 of of histone H3. It serves as a transcriptional activator for many target genes, including several HOX genes. MLL is a frequent target for translocations in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed lineage leukemia (MLL). A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3 Lys4 methyltransferase activity. MLL1 is found in a complex of proteins that includes ASH2L, WDR5, DPY30 and RBBP5.

Immunogen :

This MLL1 antibody was raised against a recombinant protein corresponding to amino acids 161-356 of mouse MLL1.

Uses :

ChIP, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody was used as described in ChIP: Jin, S. et al. (2010) J Clin Invest 281: 593-606. IP: Yokoyama, A. et al. (2009) Blood 100: 3710-3718. WB: Yokoyama, A. et al. (2009) Blood 100: 3710-3718.