BRG-1 antibody (mAb) | Active Motif 39807 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

BRG-1 antibody (mAb)

catalog :

39807

quantity :

100 ug

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

3G4

reactivity :

human

application :

western blot, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human	Joliot V, Ait Mohamed O, Battisti V, Pontis J, Philipot O, Robin P, et al. The SWI/SNF subunit/tumor suppressor BAF47/INI1 is essential in cell cycle arrest upon skeletal muscle terminal differentiation. PLoS ONE. 2014;9:e108858 pubmed publisher

product information

Catalog Number :

39807

Product Name :

BRG-1 antibody (mAb)

Host Species :

Rat

Clonality :

Monoclonal

Size :

100 ug

Clone :

3G4

Isotype :

IgG2b

CrossReactivity :

Human, Mouse

Background :

BRG1 (Brahma-related gene-1, SNF2M-NM-2) is the central catalytic ATPase subunit of numerous chromatin-remodeling complexes, including SWI/SNF. These complexes are able to use energy from ATP hydrolysis to physically disrupt chromatin architecture of target promoters and facilitate the binding of transcription factors to nucleosomal DNA. BRG1 is a co-regulator of transcription and has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. This protein plays a major role in many cellular processes such as DNA replication, repair and recombination. Mammalian BRG1 is usually associated with approximately 10-12 BAF subunits or other proteins involved in regulation of gene expression. BRG1 is part of the stem cell-specific BAF complex, esBAF, and is involved in regulating stem cell pluripotency.

Immunogen :

This BRG-1 antibody was raised against a recombinant protein corresponding to amino acids 214-279 of mouse BRG1.

Uses :

IF, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody was used in immunofluorescence and Western blot as described below: Ohkawa, Y. et al. (2009) Hybridoma 28: 463-466.