MITF antibody (mAb) | Active Motif 39789 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

MITF antibody (mAb)

catalog :

39789

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, chromatin immunoprecipitation, ChIP-Seq

product information

Catalog Number :

39789

Product Name :

MITF antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Isotype :

IgG

CrossReactivity :

Human

Background :

MITF protein (Microphthalmia-associated Transcription Factor) is a basic helix-loop-helix type transcription factor involved in the differentiation and development of retinal pigment epithelium and melanocytes. It is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes tyrosinase and tyrosinase related protein 1. For activity MITF needs to heterodimerize with other bHLH proteins such as TFE3, TFEB or TFE. Defects in MITF are the cause of Waardenburg syndrome type 2A and Tietz syndrome.

Immunogen :

This MITF antibody was raised against an N-terminal fragment of human MITF.

Uses :

ChIP, ChIP-chip, ChIP-Seq, EMSA, IF, IHC, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used as described below:ChIP: Esumi, N. et al. (2007) J Biol Chem 282: 1838-1850.EMSA: Du, J. et al. (2003) Am J Path 163: 333-343.IF: Wellbrock, C. and Marais, R. (2005) J Cell Biol 170: 703-708.IP: Hemesath, P. et al. (1998) Nature 391: 298-301.WB: Wellbrock, C. and Marais, R. (2005) J Cell Biol 170: 703-708; Hemesath, P. et al. (1998) Nature 391: 298-301.