SUV39H1 antibody (mAb) | Active Motif 39785 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

SUV39H1 antibody (mAb)

catalog :

39785

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MG44

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:200; loading ...; fig s3c	de Castro I, Budzak J, Di Giacinto M, Ligammari L, Gokhan E, Spanos C, et al. Repo-Man/PP1 regulates heterochromatin formation in interphase. Nat Commun. 2017;8:14048 pubmed publisher

product information

Catalog Number :

39785

Product Name :

SUV39H1 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

MG44

Isotype :

IgG1

CrossReactivity :

Human, Mouse

Background :

SUV39H1 is one of two homologues of the Drosophila Supressor-of-variegation 3(9) protein (aka Su(var)3-9). SUV39H1 is a SET domain-containing histone methyltransferase specific for lysine 9 of histone H3. Lysine 9 methylation of histone H3 is found at regions of the genome that are transcriptionally silenced, such as centromeres, repetitive elements and inactive genes. H3 lysine 9 methylation is a hallmark of heterochromatin, regions of the genome that are in a tightly compacted state and relatively devoid of gene expression. HP1 proteins recognize and bind lysine 9 methylation and this contributes to maintaining heterochromatin in its compact and inactive state. SUV39H1 also contains a chromodomain, which may bind to lysine 9 methylation and contribute to the regional spreading of lysine 9 methylation and the establishment of heterochromatin over broader domains of the genome.

Immunogen :

This SUV39H1 antibody was raised against a recombinant protein corresponding to amino acids 1-126 of mouse SUV39H1.

Uses :

ChIP, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody was used in the following applications as described:Chromatin IP: Lee et al. (2010) Mol Cancer 9: 64-75 Immunoprecipitation: Zhou et al. (2008) RNA 14: 1773-1781 Western blot: Terada et al. (2006) Mol Cell Biol 17: 3232-3241