PML antibody (mAb) | Active Motif 39773 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

PML antibody (mAb)

catalog :

39773

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

36.1-104

reactivity :

mouse

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

39773

Product Name :

PML antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

36.1-104

Isotype :

IgG

CrossReactivity :

Mouse

Background :

PML (Promyelocytic Leukemia) protein is a transcription factor originally identified due to a chromosomal aberration fusing it to the Retinoic Acid Receptor alpha (RAR-A) in cases of Acute Promyelocytic Leukemia (APL). Besides transcriptional regulation, PML is involved in many processes, including the response to DNA damage, cell cycle regulation, viral infection response and apoptosis. These functions of PML involve the localization of PML to unique sub-nuclear structures called PML Nuclear Bodies (PML NBs). Over fifty proteins are know to be localized to PML NBs, either transiently or constitutively. These Nuclear Bodies are disrupted in PML knockout mice. PML is subject to a number of post-translational modifications, including phosphorylation, ubiquitylation and sumoylation.

Immunogen :

This PML antibody was raised against a recombinant protein corresponding to amino acids 1-581 of mouse PML.

Uses :

IF, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody was used in the various applications as described: Immunoprecipitation: Evdokimov, E. et al. (2008) J Cell Sci 121: 4106 - 4113. Immunofluorescence: Evdokimov, E. et al. (2008) J Cell Sci 121: 4106 - 4113.Western blotting: Evdokimov, E. et al. (2008) J Cell Sci 121: 4106 - 4113.