p63 antibody (pAb) | Active Motif 39739 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

p63 antibody (pAb)

catalog :

39739

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, ChIP-Seq

citations: 4

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; fig 6	Katoh I, Fukunishi N, Fujimuro M, Kasai H, Moriishi K, Hata R, et al. Repression of Wnt/Î²-catenin response elements by p63 (TP63). Cell Cycle. 2016;15:699-710 pubmed publisher
ChIP-Seq; human; fig s8	Drier Y, Cotton M, Williamson K, Gillespie S, Ryan R, Kluk M, et al. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet. 2016;48:265-72 pubmed publisher
	Hsieh M, Choe J, Gadhvi J, Kim Y, Arguez M, Palmer M, et al. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019;28:1860-1878.e9 pubmed publisher
	Pattison J, Melo S, Piekos S, Torkelson J, Bashkirova E, Mumbach M, et al. Retinoic acid and BMP4 cooperate with p63 to alter chromatin dynamics during surface epithelial commitment. Nat Genet. 2018;50:1658-1665 pubmed publisher

product information

Catalog Number :

39739

Product Name :

p63 antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ul

Isotype :

IgG

CrossReactivity :

Human

Background :

p63 is a sequence-specific DNA binding transcription factor that is related to the p53 protein. p63 binds to and regulates a subset of genes also regulated by p53. p63 has been postulated to have a critical role in maintaining the identity of epithelial cell layers by regulating the differentiation of epithelial stem cells. Defects in p63 are associated with a number of developmental disorders involving the limbs and palate, as well as a variety of head and neck cancers.

Immunogen :

This p63 antibody was raised against a recombinant protein corresponding to full length human p63.

Uses :

ChIP, IF, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.