Phc1 antibody (mAb) | Active Motif 39723 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Phc1 antibody (mAb)

catalog :

39723

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6-1-3

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:2000; loading ...; tbl s3	Lau M, Schwartz M, Kundu S, Savol A, Wang P, Marr S, et al. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017;355:1081-1084 pubmed publisher
western blot; human	Lin S, Shen H, Li J, Tang S, Gu Y, Chen Z, et al. Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program. J Biol Chem. 2013;288:6238-47 pubmed publisher
	Zhen C, Duc H, Kokotovic M, Phiel C, Ren X. Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Mol Biol Cell. 2014;25:3726-39 pubmed publisher

product information

Catalog Number :

39723

Product Name :

Phc1 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

100 ug

Clone :

6-1-3

Isotype :

IgG

CrossReactivity :

Human

Background :

Phc1, polyhomeotic homolog 1 (also known as EDR1, early development regulatory protein 1) is a component of the polycomb group (PcG) multiprotein PRC1 complex. The PRC1 complex is required to maintain the stable repression of the Hox genes during development. This chromatin-associated protein complex acts via chromatin remodeling and histone modifications. Phc1 has been shown to interact with PHC2, BMI1, MAPKAPK2 and MCRS1.

Immunogen :

This antibody was raised against full length recombinant mouse Phc1 protein.

Uses :

IF, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: 1. Miyagishima et al (2003) Histochem Cell Biol 120: 111-119.2. Isono, K. et. al. (2005) Mol. Cell. Bio. 25: 6694-6706.