NFM-NM-:B p65 phospho Ser536 antibody (pAb) | Active Motif 39675 product information

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product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

NFM-NM-:B p65 phospho Ser536 antibody (pAb)

catalog :

39675

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Catalog Number :

39675

Product Name :

NFM-NM-:B p65 phospho Ser536 antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Size :

100 ul

Isotype :

Serum

CrossReactivity :

Human

Background :

NFM-NM-:B p65 (Nuclear factor NF-kappa-B p65 subunit also known as NFM-NM-:B p65 or RelA) is a member of the Rel family of transcription factors that are involved in processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. The Rel family includes c-Rel, RelA (NFM-NM-:B p65, NFM-NM-:B3) and RelB (I-Rel). Rel proteins form dimers with the NFM-NM-:B p50 (proteolytically processed from p105/NFM-NM-:B1)and p52 (proteolytically processed from p100/NFM-NM-:B2) members of the NFM-NM-:B family that bind DNA and activate transcription. The NFM-NM-:B p65/p50 heterodimer is the most abundant form of NFM-NM-:B.NFM-NM-:B signaling is negatively regulated by the sequestration of the NFM-NM-:B complex in the cytoplasm by its association with the IM-NM-:B family of inhibitory proteins. The IM-NM-:B Kinase (IKK) complex is the key enzyme involved in the activation and translocation of NFM-NM-:B. The IKK complex is composed of two catalytic subunits (IKKM-NM-1 and IKKM-NM-2) and a regulatory subunit (IKKM-NM-3). Upon its activation, the IKK complex phosphorylates IM-NM-:B proteins (IM-NM-:BM-NM-1, IM-NM-:BM-NM-1 phospho Ser32, 36), which marks them for ubiquitination and degradation. This enables the NFM-NM-:B complex to translocate to the nucleus where it regulates transcription by binding to DNA.Phosphorylation at serine 536 stimulates acetylation at lysine 310 and interaction with the acetyltransferase CBP. The phosphorylated and acetylated forms show enhanced transcriptional activity.

Immunogen :

This NFM-NM-:B p65 phospho Ser536 antibody was raised against a peptide containing phospho-serine 536 of human NFM-NM-:B p65.

Uses :

DB, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.