p53 antibody (mAb) | Active Motif 39553 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

p53 antibody (mAb)

catalog :

39553

quantity :

200 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DO1

The same clone is also sold as:

Bio-Rad: MCA1701B, MCA1701
MyBioSource: MBS212262
Invitrogen: AHO0152, MA5-12571
BioLegend: 645702, 645701, 645706, 645705
BD Biosciences: 554293
Santa Cruz Biotechnology: sc-126 HRP, sc-126 AC, sc-126 X, sc-126
Cell Signaling Technology: 18032
MilliporeSigma: P6874
OriGene: TA804804BM, TA804804S, CF804804, TA804804AM, TA804804
Abcam: ab1101, ab204452, ab237976

reactivity :

human

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human	Girardot M, Pecquet C, Chachoua I, Van Hees J, Guibert S, Ferrant A, et al. Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene. 2015;34:1323-32 pubmed publisher
	Chen W, Ebelt N, Stracker T, Xhemalce B, Van Den Berg C, Miller K. ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion. elife. 2015;4: pubmed publisher

product information

Catalog Number :

39553

Product Name :

p53 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

200 ug

Clone :

DO1

Isotype :

IgG

CrossReactivity :

Human

Background :

p53 is the most important tumor suppressor in the genome. It is responsive to numerous genotoxic stresses, which activates its transcription factor activity, in turn causing cell-cycle arrest by activating expression of p21 Cip/WAF. Mutant p53 that has lost its DNA-binding function interferes with the activity of native p53 and leads to oncogenic transformation. Alternatively, transformation may be caused by overexpression of Mdm2/Hdm2, a ubiquitin ligase specific for p53, which causes its destabilization. Inactivation of p53 is often coincident with hyperactivation of NFM-NM-:B (NFM-NM-:B p50 and NFM-NM-:B p65), both of which serve to inhibit apoptosis.

Immunogen :

This p53 antibody was raised against full-length recombinant human p53 protein.

Uses :

IP, WB

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.