ATM phospho Ser1981 antibody (mAb) | Active Motif 39529 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

ATM phospho Ser1981 antibody (mAb)

catalog :

39529

quantity :

200 ul

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10H11.E.12

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; loading ...; fig 2b	Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed publisher
immunocytochemistry; mouse	Flach J, Bakker S, Mohrin M, Conroy P, Pietras E, Reynaud D, et al. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. 2014;512:198-202 pubmed publisher
western blot; mouse	Li X, Corsa C, Pan P, Wu L, Ferguson D, Yu X, et al. MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol Cell Biol. 2010;30:5335-47 pubmed publisher
	Shrivastav M, Miller C, De Haro L, Durant S, Chen B, Chen D, et al. DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst). 2009;8:920-9 pubmed publisher

product information

Catalog Number :

39529

Product Name :

ATM phospho Ser1981 antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Size :

200 ul

Clone :

10H11.E.12

Isotype :

IgG1k

CrossReactivity :

Human, Mouse

Background :

ATM M-bM-^@M-^S Ataxia Telangiectasia Mutated is a PI3-family protein kinase and a critical cell cycle checkpoint protein. ATM and a related protein, ATR, play crucial roles in the maintenance of genome integrity and the response to DNA damage. Upon activation, ATM phosphorylates itself at serine 1981 and then phosphorylates a number of downstream proteins (e.g. BRCA1, CHK2, H2AX, p53, NBS1, SMC1) resulting in cell cycle arrest and the initiation of DNA damage repair. Loss of function of ATM is causal to a variety of syndromes involving increased incidence of several cancers.

Immunogen :

This ATM phospho Ser1981 antibody was raised against a peptide containing phospho-serine 1981 of human ATM.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody was used in Bakkenist and Kastan (2003) Nature 421:499.