p53 antibody (pAb) | Active Motif 39334 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

p53 antibody (pAb)

catalog :

39334

quantity :

17 rxns

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunoprecipitation, EMSA, chromatin immunoprecipitation

product information

Catalog Number :

39334

Product Name :

p53 antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

17 rxns

Isotype :

IgG

CrossReactivity :

Human

Background :

p53 is the most important tumor suppressor in the genome. It is responsive to numerous genotoxic stresses, which activates its transcription factor activity, in turn causing cell-cycle arrest by activating expression of p21 Cip/WAF. Mutant p53 that has lost its DNA-binding function interferes with the activity of native p53 and leads to oncogenic transformation. Alternatively, transformation may be caused by overexpression of Mdm2/Hdm2, a ubiquitin ligase specific for p53, which causes its destabilization. Inactivation of p53 is often coincident with hyperactivation of NFM-NM-:B (NFM-NM-:B p50 and NFM-NM-:B p65), both of which serve to inhibit apoptosis.

Immunogen :

This p53 antibody was raised against a synthetic peptide corresponding to amino acid residues 367-381 of human p53.

Uses :

ChIP, EMSA, IP

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.