HP1M-NM-1 antibody (pAb) | Active Motif 39295 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

HP1M-NM-1 antibody (pAb)

catalog :

39295

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 1

Reference
Wike C, Graves H, Hawkins R, Gibson M, Ferdinand M, Zhang T, et al. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. elife. 2016;5:e11402 pubmed publisher

product information

Catalog Number :

39295

Product Name :

HP1M-NM-1 antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

200 ul

Isotype :

Serum

CrossReactivity :

Human, Mouse

Background :

HP1 (Heterochromatin protein 1) is a chromosomal protein that participates in both chromatin packaging and gene silencing. Three HP1 isoforms (M-NM-1, M-NM-2 and M-NM-3) occur in mammals. The chromodomain (Chromatin Organization Modifier) of HP1M-NM-1 is responsible for binding to Histone H3 methyl Lys9, although additional factors are required to specify the HP1 targeting. The chromoshadow domain mediates interactions with a number of nuclear proteins, including SuvH39 (a Histone H3 Lysine methyltransferase), the DNA methyltransferases DNMT1 and DNMT3A or the large subunit of the chromatin assembly factor-1 (CAF-1). Dysfunction of HP1M-NM-1 plays a critical role in tumorigenesis, and is implicated in the invasive/metastatic phenotype of breast cancer.

Immunogen :

This HP1 alpha antibody was raised against a recombinant protein corresponding to full-length recombinant mouse HP1 alpha.

Uses :

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.