Lamin A/C antibody (mAb) | Active Motif 39287 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Lamin A/C antibody (mAb)

catalog :

39287

quantity :

200 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A6-4C11

The same clone is also sold as:

Invitrogen: 14-9847-82

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 5d	Xiong L, Zhao K, Cao Y, Guo H, Pan J, Yang X, et al. Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency. PLoS Biol. 2020;18:e3000731 pubmed publisher
western blot; human; loading ...; fig 6b	Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed publisher
immunocytochemistry; human; loading ...; fig 2c	Drozdz M, Jiang H, Pytowski L, Grovenor C, Vaux D. Formation of a nucleoplasmic reticulum requires de novo assembly of nascent phospholipids and shows preferential incorporation of nascent lamins. Sci Rep. 2017;7:7454 pubmed publisher
western blot; mouse; fig 1	Guo Y, Zheng Y. Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell. 2015;26:3379-89 pubmed publisher
immunocytochemistry; mouse; 1:1000	Sugo N, Morimatsu M, Arai Y, Kousoku Y, Ohkuni A, Nomura T, et al. Single-Molecule Imaging Reveals Dynamics of CREB Transcription Factor Bound to Its Target Sequence. Sci Rep. 2015;5:10662 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:1000 western blot; mouse; 1:1000	Kim Y, Zheng Y. Generation and characterization of a conditional deletion allele for Lmna in mice. Biochem Biophys Res Commun. 2013;440:8-13 pubmed publisher
	Caporali A, Meloni M, Nailor A, Mitić T, Shantikumar S, Riu F, et al. p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nat Commun. 2015;6:8024 pubmed publisher
	Brown C, Esterházy D, Sarde A, London M, Pullabhatla V, Osma Garcia I, et al. Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program. Immunity. 2015;42:499-511 pubmed publisher

product information

Catalog Number :

39287

Product Name :

Lamin A/C antibody (mAb)

Host Species :

Mouse

Clonality :

Monoclonal

Size :

200 ug

Clone :

3A6-4C11

Isotype :

IgG

CrossReactivity :

Hamster, Human, Monkey, Mouse, Rat

Background :

Nuclear lamins are intermediate filament proteins that are the major structural component of the nuclear lamina on the inner surface of the nuclear envelope. Lamins A and Lamins C are splice variants of the Lamin A gene. Lamin A/C (CDCD1, LMN1, EMD2) expression is a hallmark of embryonic stem cell differentiation. In addition to adding structural integrity to the nucleus, lamins contribute to the makeup of the nuclear matrix. Lamins also help organize interphase chromatin through interactions with several chromatin proteins, including histones and Lap2, such that alteration in lamin organization results in disruption of DNA replication, transcription and RNA processing.

Immunogen :

This Lamin A/C antibody was raised against a recombinant protein corresponding to amino acids 430-545 of human Lamin A.

Uses :

IF, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.